Affinage

BAG5

BAG family molecular chaperone regulator 5 · UniProt Q9UL15

Length
447 aa
Mass
51.2 kDa
Annotated
2026-06-09
44 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

BAG5 is a multi-BAG-domain co-chaperone that couples Hsp70/HSC70 chaperone cycling to the control of protein stability and quality-control E3 ligase activity across neuronal, cardiac, tumor, and germ-cell contexts (PMID:15603737, PMID:20223214). Its fifth BAG domain (BD5) binds the Hsp70 nucleotide-binding domain and triggers conformational changes that disrupt the nucleotide-binding groove, lowering ADP affinity and accelerating Hsp70-mediated refolding — establishing BAG5 as a nucleotide exchange factor (PMID:20223214), an activity it likewise exerts on HSC70 to drive substrate folding (PMID:35044787). A recurrent theme is that BAG5 restrains E3 ubiquitin ligases: it inhibits Parkin and CHIP and antagonizes MDM2, thereby stabilizing substrates including alpha-synuclein, PTEN, and mutant p53 (PMID:15603737, PMID:21358815, PMID:24148769, PMID:27807478). In Parkinson-relevant models BAG5 sequesters Parkin in aggregates, enhances dopaminergic neuron death, and impairs Parkin-dependent mitophagy while promoting alpha-synuclein oligomerization (PMID:15603737, PMID:31787745, PMID:21358815); in cancer it stabilizes gain-of-function mutant p53 to promote proliferation and chemoresistance (PMID:27807478). BAG5 also acts at the ER, binding GRP78/BiP and modulating the unfolded protein response, and relocalizes to the ER under stress (PMID:23448667). Loss-of-function mutations in BAG5 cause inherited dilated cardiomyopathy, where BAG5 localizes to cardiomyocyte junctional membrane complexes and its NEF activity toward HSC70 maintains JMC structure and calcium handling, with AAV9-delivered wild-type BAG5 rescuing the phenotype in mice (PMID:35044787, PMID:38796549). In the male germline BAG5 partners with HSPA8 and HSPA2 to fold structural substrates such as SPATA6 required for sperm head-tail coupling, and its loss causes acephalic spermatozoa and male infertility (PMID:38454159, PMID:39992433).

Mechanistic history

Synthesis pass · year-by-year structured walk · 21 steps
  1. 2004 High

    Established BAG5 as a dual-action regulator that simultaneously suppresses Parkin E3 ligase activity and Hsp70 refolding, linking it to dopaminergic neurodegeneration.

    Evidence Co-IP, in vitro ubiquitin ligase assay, and in vivo dopamine neuron loss model with dominant-negative rescue

    PMID:15603737

    Open questions at the time
    • Did not resolve which BAG domain mediates Parkin versus Hsp70 binding
    • Structural basis of Hsp70 inhibition not defined
  2. 2010 High

    Defined the molecular mechanism of BAG5 action on Hsp70, showing BD5 acts as a nucleotide exchange factor by remodeling the NBD to release ADP.

    Evidence Crystal structure of BD5-NBD complex with ADP-affinity and in vitro refolding assays

    PMID:20223214

    Open questions at the time
    • Roles of the other four BAG domains in chaperone modulation not structurally resolved
    • How NEF activity relates to inhibition of refolding seen earlier unclear
  3. 2010 Low

    Extended the Parkin connection by showing BAG5 binds Parkin through all four BAG domains and stabilizes Parkin against proteasomal degradation.

    Evidence GST pulldown, co-IP, cycloheximide chase/ubiquitination assay

    PMID:21131737

    Open questions at the time
    • Single lab with limited methodological detail
    • Reconciliation with Parkin sequestration/inhibition model not addressed
  4. 2011 High

    Showed BAG5 inhibits a second E3 ligase, CHIP, toward alpha-synuclein, generalizing its role as an antagonist of chaperone-associated ubiquitination.

    Evidence Co-IP from brain, in vitro ubiquitinylation assay, luciferase complementation oligomerization assay

    PMID:21358815

    Open questions at the time
    • Whether increased oligomerization is toxic in vivo not established here
    • Stoichiometry of the BAG5-CHIP-Hsp70-synuclein complex undefined
  5. 2013 Medium

    Identified an ER-resident function: BAG5 binds GRP78/BiP, modulates UPR branches, and relocalizes to the ER under stress to suppress apoptosis.

    Evidence Co-IP, ATPase assay, subcellular fractionation, knockdown/overexpression apoptosis readouts

    PMID:23448667

    Open questions at the time
    • Mechanism of stress-triggered ER relocalization unknown
    • How BAG5 differentially tunes PERK versus IRE1 arms not resolved
  6. 2013 Low

    Linked BAG5's CHIP inhibition to PTEN stabilization, broadening its substrate range.

    Evidence Co-IP, ubiquitination assay, western blot

    PMID:24148769

    Open questions at the time
    • Mechanistic inference from CHIP inhibition with limited orthogonal validation
    • Physiological context of PTEN regulation not defined
  7. 2014 Medium

    Showed BAG5 stabilizes PINK1 by reducing its ubiquitination, protecting against mitochondrial toxin damage and tying BAG5 into mitochondrial quality control.

    Evidence Yeast two-hybrid, GST pulldown, co-IP, ubiquitination assay, toxin viability assay

    PMID:24475098

    Open questions at the time
    • Reconciliation with later mitophagy-impairing role not addressed
    • E3 ligase acting on PINK1 not identified
  8. 2014 Low

    Added polyQ disease context by showing BAG5 (with BAG2) stabilizes pathogenic ataxin3-80Q.

    Evidence Co-immunofluorescence, western blot, ubiquitination assay

    PMID:25006867

    Open questions at the time
    • No direct binding assay described
    • Single lab, limited mechanistic detail
  9. 2016 Medium

    Demonstrated an oncogenic role: BAG5 protects mutant p53 from MDM2- and CHIP-mediated degradation, enabling gain-of-function tumor phenotypes.

    Evidence Co-IP, ubiquitination assay, proliferation/migration/tumor growth assays

    PMID:27807478

    Open questions at the time
    • Selectivity for mutant versus wild-type p53 mechanism unclear
    • In vivo tumor dependence on BAG5 not fully delineated
  10. 2017 Low

    Reported BAG5 destabilizes DJ-1 and weakens its mitochondrial protection, a directionally distinct effect from its substrate-stabilizing roles.

    Evidence Co-IP, immunofluorescence, western blot

    PMID:28348719

    Open questions at the time
    • Effect on DJ-1 dimerization not directly demonstrated
    • Mechanism of destabilization undefined
  11. 2019 Medium

    Resolved BAG5's role in mitophagy, showing it suppresses Parkin recruitment to damaged mitochondria while enhancing Parkin-mediated Mcl-1 degradation and death, revealing bimodal control.

    Evidence Live-cell mitochondrial recruitment imaging, lysosomal colocalization, cell death and Mcl-1 degradation assays

    PMID:31787745

    Open questions at the time
    • Molecular switch governing the bimodal outcome unknown
    • Relationship to PINK1 stabilization not integrated
  12. 2020 Medium

    Connected BAG5 to autophagy machinery via p62/SQSTM1 interaction and showed it promotes pathogenic alpha-synuclein oligomers.

    Evidence Co-IP, oligomerization assay, subcellular fractionation/immunofluorescence

    PMID:32850835

    Open questions at the time
    • Whether p62 binding alters autophagic flux not quantified
    • Direct versus indirect effect on oligomerization unresolved
  13. 2020 Medium

    Placed BAG5 downstream of p53 transcriptionally, showing stress-induced p53 binds the BAG5 promoter and BAG5 is required for alpha-synuclein aggregation.

    Evidence ChIP, co-IP from PD patient brain lysates, siRNA knockdown aggregation assay

    PMID:33085644

    Open questions at the time
    • Feedback between p53-induced BAG5 and BAG5's stabilization of mutant p53 not explored
    • In vivo relevance of the axis untested
  14. 2020 Medium

    Identified PRMT6 methylation of BAG5 as a post-translational switch controlling HSC70 stability, autophagy, and hepatocellular tumorigenicity.

    Evidence Co-IP, methylation assay, BAG5 knockdown with in vivo tumor model

    PMID:33186656

    Open questions at the time
    • Methylated residues and their effect on NEF activity not mapped
    • Generality beyond HCC unknown
  15. 2020 Low

    Reported a translational-regulatory function in thyroid cancer, with BAG5 modulating FN1 via miR-144-3p to promote invasion.

    Evidence Overexpression/knockdown, polysome fractionation, invasion assay, miR-144-3p functional assay

    PMID:32275930

    Open questions at the time
    • Mechanistic link between BAG5 and miRNA suppression unclear
    • Limited detail and single lab
  16. 2022 High

    Established BAG5 as a disease gene for inherited dilated cardiomyopathy and defined its cardiac mechanism as HSC70 NEF activity supporting junctional membrane complex structure and calcium handling.

    Evidence Human genetics, knock-in mouse phenocopy, JMC localization, calcium assays, AAV9 gene rescue

    PMID:35044787

    Open questions at the time
    • Identity of the structural folding substrates at the JMC not defined
    • Why cardiac tissue is selectively vulnerable unclear
  17. 2023 Medium

    Showed BAG5 regulates Akt stability by switching Akt from mono- to polyubiquitination, with the complex governed by phosphorylation and growth-factor signaling.

    Evidence Co-IP, domain mapping, ubiquitination switch assay, knockdown/overexpression Akt stability readouts

    PMID:38139359

    Open questions at the time
    • E3 ligase mediating the ubiquitination switch not identified
    • Physiological signaling outcomes of Akt regulation untested
  18. 2024 High

    Defined an essential germ-cell role: BAG5 partners HSPA8 to fold SPATA6 and other structural proteins, and its loss causes acephalic spermatozoa and infertility.

    Evidence BAG5 knockout mouse, co-IP, in vitro chaperone substrate-affinity assay, spermatid immunofluorescence

    PMID:38454159

    Open questions at the time
    • How BAG5 selects this specific substrate set is unknown
    • Whether NEF activity alone accounts for folding enhancement unresolved
  19. 2024 Medium

    Provided a second human DCM variant and tied cardiac dysfunction to an impaired ER stress response in vivo.

    Evidence Human exome/Sanger sequencing, knock-in mouse with tunicamycin challenge, echocardiography, apoptosis assay

    PMID:38796549

    Open questions at the time
    • Relationship between ER stress defect and JMC/calcium phenotype not integrated
    • Causal UPR branch in the heart not pinpointed
  20. 2025 Medium

    Extended germline function to earlier stages, showing BAG5 stabilizes HSPA2 in spermatocytes to support nuclear protein exchange and prevent germ cell apoptosis.

    Evidence Bag5 knockout mouse, IP-mass spectrometry, co-IP, testis RNA-seq, western blot

    PMID:39992433

    Open questions at the time
    • Direct chaperone substrates of the BAG5-HSPA2 complex not defined
    • Mechanism linking HSPA2 loss to TNP/PRM transcription unclear
  21. 2026 Low

    Reported BAG5 partnering with HSPA1A to promote ATF2 degradation and dampen apoptotic signaling in spermatogenic cells.

    Evidence Co-IP-mass spectrometry, co-IP validation, ubiquitination assay, overexpression/knockdown

    PMID:41558067

    Open questions at the time
    • Single lab with limited independent replication
    • E3 ligase mediating ATF2 degradation not identified

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how a single BAG5 NEF/co-chaperone activity is mechanistically partitioned to produce opposite outcomes — substrate stabilization versus destabilization, mitochondrial protection versus mitophagy suppression — across its different tissue and substrate contexts.
  • No unifying structural/biophysical model linking the four BAG domains plus BD5 to context-specific outcomes
  • Determinants of substrate selection across neurons, heart, germline, and tumor cells unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 5 GO:0140096 catalytic activity, acting on a protein 4 GO:0044183 protein folding chaperone 3
Localization
GO:0005783 endoplasmic reticulum 2 GO:0005829 cytosol 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-392499 Metabolism of proteins 3 R-HSA-5357801 Programmed Cell Death 3 R-HSA-8953897 Cellular responses to stimuli 2 R-HSA-9612973 Autophagy 2
Partners
AKTCHIPGRP78HSPA2HSPA8P62PARKINPINK1
Complex memberships
BAG5-CHIP-Hsp70-alpha-synuclein complexBAG5-HSPA8 complexBAG5-Hsp70-Parkin complexjunctional membrane complex (cardiomyocyte)

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 BAG5 directly interacts with parkin and Hsp70. Within this complex, BAG5 inhibits parkin E3 ubiquitin ligase activity and Hsp70-mediated refolding of misfolded proteins. BAG5 enhances parkin sequestration within protein aggregates and mitigates parkin-dependent preservation of proteasome function, enhancing dopamine neuron death in an in vivo PD model. Co-immunoprecipitation, in vitro ubiquitin ligase assay, in vivo dopamine neuron loss model, dominant-negative BAG5 mutant rescue Neuron High 15603737
2010 The fifth BAG domain (BD5) of BAG5 is responsible for interaction with the Hsp70 nucleotide-binding domain (NBD). Crystal structures of the BD5-NBD complex reveal that BD5 binding causes conformational changes in the NBD that disrupt the nucleotide-binding groove, reducing NBD affinity for ADP. BD5 and full-length BAG5 accelerate Hsp70-mediated refolding in vitro, establishing BAG5 as a nucleotide exchange factor (NEF) for Hsp70. Crystal structure determination, in vitro ADP-binding affinity assay, in vitro protein refolding assay Structure High 20223214
2011 BAG5 forms a protein complex with CHIP (E3 ubiquitin ligase) and alpha-synuclein in brain, mediated by Hsp70 binding to CHIP's TPR domain and BAG5's BAG domains. BAG5 inhibits CHIP E3 ubiquitin ligase activity toward alpha-synuclein, reducing alpha-synuclein ubiquitinylation and thereby increasing alpha-synuclein oligomerization. Co-immunoprecipitation from brain tissue, in vitro ubiquitinylation assay, luciferase protein-fragment complementation assay of alpha-synuclein oligomerization PloS one High 21358815
2013 BAG5 interacts with the ER-resident chaperone GRP78/BiP and enhances its ATPase activity. During ER stress, BAG5 relocates from the cytoplasm to the ER and inhibits ER-stress-induced apoptosis by suppressing the PERK-eIF2-ATF4 axis while enhancing the IRE1-Xbp1 axis of the unfolded protein response. Co-immunoprecipitation, ATPase activity assay, subcellular fractionation/relocalization, siRNA knockdown and overexpression with apoptosis readouts BMC cancer Medium 23448667
2014 BAG5 directly interacts with PINK1, stabilizes PINK1 by decreasing its ubiquitination, and thereby protects against mitochondrial dysfunction induced by MPP+ and rotenone. Yeast two-hybrid, GST pulldown, co-immunoprecipitation, ubiquitination assay, cell viability assay with mitochondrial toxins PloS one Medium 24475098
2013 BAG5, as an inhibitor of CHIP E3 ubiquitin ligase activity, reduces CHIP-mediated ubiquitination and degradation of PTEN, thereby maintaining PTEN protein levels via a ubiquitylation-dependent pathway. Co-immunoprecipitation, ubiquitination assay, western blot BMB reports Low 24148769
2014 BAG2 and BAG5 stabilize pathogenic ataxin3-80Q by inhibiting its ubiquitination, as shown by co-immunofluorescence and western blotting experiments. Co-immunofluorescence, western blotting, ubiquitination assay The International journal of neuroscience Low 25006867
2016 BAG5 interacts with mutant p53 (mutp53) proteins and protects mutp53 from ubiquitination and degradation by E3 ubiquitin ligases MDM2 and CHIP, leading to mutp53 accumulation and gain-of-function activities including increased cell proliferation, tumor growth, cell migration, and chemoresistance. Co-immunoprecipitation, ubiquitination assay, siRNA knockdown and overexpression with proliferation/migration/tumor growth assays Cell discovery Medium 27807478
2017 BAG5 interacts with DJ-1 in mammalian cells, decreases DJ-1 stability, and weakens DJ-1's role in mitochondrial protection, possibly by influencing DJ-1 dimerization under stress conditions. Co-immunoprecipitation, immunofluorescence, western blot Oxidative medicine and cellular longevity Low 28348719
2019 BAG5 impairs Parkin-dependent mitophagy by suppressing Parkin recruitment to damaged mitochondria and reducing movement of damaged mitochondria into lysosomes. BAG5 also enhances Parkin-mediated Mcl-1 degradation and cell death following severe mitochondrial insult, suggesting BAG5 regulates the bi-modal activity of Parkin. Live-cell imaging of mitochondrial recruitment, lysosomal colocalization assay, cell death assays, Mcl-1 degradation assay Cell death & disease Medium 31787745
2020 BAG5 interacts with p62/SQSTM1, enhances formation of pathogenic alpha-synuclein oligomers, and regulates the levels and subcellular distribution of p62, bridging the chaperone network to autophagy-mediated protein degradation. Co-immunoprecipitation, alpha-synuclein oligomerization assay, subcellular fractionation/immunofluorescence Frontiers in cell and developmental biology Medium 32850835
2020 Stress-induced p53 binds directly to the BAG5 promoter to stimulate BAG5 expression. Induced BAG5 binds alpha-synuclein and Hsp70 in cell cultures and PD patient brain lysates, and BAG5 expression is required for alpha-synuclein aggregation in SH-SY5Y cells. ChIP assay (p53 binding to BAG5 promoter), co-immunoprecipitation from brain lysates, siRNA knockdown with aggregation readout Aging Medium 33085644
2020 PRMT6 physically interacts with and methylates BAG5, and this methylation enhances degradation of BAG5's binding partner HSC70. PRMT6 deficiency leads to increased BAG5-associated HSC70 stability, promoting autophagy and tumorigenicity in hepatocellular carcinoma. Co-immunoprecipitation, methylation assay, genetic knockdown of BAG5 with in vivo tumor model Cancer letters Medium 33186656
2022 Loss-of-function mutations in BAG5 cause inherited dilated cardiomyopathy. BAG5 acts as a nucleotide exchange factor for HSC70, promoting ADP release and activating HSC70-mediated protein folding. BAG5 localizes to junctional membrane complexes (JMCs) in cardiomyocytes; its loss disrupts JMC structure and calcium handling. AAV9-mediated wild-type BAG5 gene delivery fully rescues the DCM phenotype in knock-in mice. Human genetics (homozygous truncating mutations), knock-in mouse model, immunocytochemistry for JMC localization, calcium handling assays, AAV9 gene rescue Science translational medicine High 35044787
2020 BAG5 modulates fibronectin 1 (FN1) expression at the translational level in papillary thyroid cancer cells, promoting invasion via suppression of miR-144-3p, which targets the 3' UTR of FN1 transcript. BAG5 overexpression/knockdown, western blot and polysome fractionation for translational regulation, invasion assay, miR-144-3p functional assay Biochimica et biophysica acta. Molecular cell research Low 32275930
2024 BAG5 forms a complex with HSPA8 in spermatids and promotes folding of SPATA6 (a sperm head-tail coupling apparatus component) by enhancing HSPA8's affinity for substrate proteins. BAG5-deficient male mice show misfolded SPATA6, MYO5A, MYL6, DYNLT1, DCTN1, and DNAL1, leading to aberrant HTCA assembly, acephalic spermatozoa syndrome, and male infertility. BAG5 knockout mouse model, co-immunoprecipitation, in vitro chaperone substrate-affinity assay, immunofluorescence of spermatid assembly EMBO reports High 38454159
2023 BAG5 interacts with Akt at the linker region between its first and second BAG domains, and Akt phosphorylates BAG5's first BAG domain. BAG5 switches Akt from monoubiquitination to polyubiquitination (together with Hsp70), promoting Akt degradation. The BAG5-Akt complex forms under serum-starved conditions and dissociates upon HGF stimulation, coincident with BAG5 phosphorylation. Co-immunoprecipitation, ubiquitination assay, BAG5 knockdown/overexpression with Akt stability readouts, deletion mapping of interaction domain International journal of molecular sciences Medium 38139359
2010 BAG5 directly interacts with Parkin through all four BAG domains and stabilizes Parkin protein by interfering with its degradation via the ubiquitin-mediated proteasomal pathway. GST pulldown, co-immunoprecipitation, cycloheximide chase/ubiquitination assay Zhong nan da xue xue bao. Yi xue ban Low 21131737
2025 BAG5 interacts with HSPA2 (testis-specific HSP70 family member) in spermatocytes. BAG5 deficiency reduces HSPA2 levels, leading to germ cell apoptosis, impaired transcription of transition proteins (TNPs) and protamines (PRMs), defective nuclear protein exchange, sperm head deformity, and male infertility. Bag5 knockout mouse model, IP-mass spectrometry, co-immunoprecipitation, RNA sequencing of knockout testis, western blot Cellular and molecular life sciences Medium 39992433
2024 A novel BAG5 frameshift variant (c.444_445delGA) causes DCM by impairing the ER stress response. Bag5-/- knock-in mice show reduced cardiac function and increased apoptosis following tunicamycin (ER stress) challenge, demonstrating BAG5 is required for normal ER stress response in the heart. Human exome/Sanger sequencing, knock-in mouse model, tunicamycin challenge, echocardiography, apoptosis assay Scientific reports Medium 38796549
2026 BAG5 interacts with HSPA1A (identified by immunoprecipitation-mass spectrometry). The HSPA1A-BAG5 complex promotes ubiquitination-mediated degradation of ATF2, subsequently downregulating apoptotic signaling in spermatogenic cells. Co-immunoprecipitation-mass spectrometry, co-immunoprecipitation validation, ubiquitination assay, overexpression/knockdown in spermatogonia/spermatocytes Tissue & cell Low 41558067

Source papers

Stage 0 corpus · 44 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. Neuron 173 15603737
2011 Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5). PloS one 124 21358815
1996 An immunohistochemical method for detecting bradyzoite antigen (BAG5) in Toxoplasma gondii-infected tissues cross-reacts with a Neospora caninum bradyzoite antigen. The Journal of parasitology 111 8604117
2010 The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange. Structure (London, England : 1993) 73 20223214
2016 CaM/BAG5/Hsc70 signaling complex dynamically regulates leaf senescence. Scientific reports 53 27539741
2016 GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes From ER Stress-Induced Apoptosis. Journal of cellular biochemistry 51 26729625
2013 Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis. BMC cancer 51 23448667
2014 BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. PloS one 48 24475098
2016 MicroRNA-127-3p acts as a tumor suppressor in epithelial ovarian cancer by regulating the BAG5 gene. Oncology reports 44 27571744
2019 Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death. Cell death & disease 40 31787745
2020 miR-155 inhibits mitophagy through suppression of BAG5, a partner protein of PINK1. Biochemical and biophysical research communications 31 31948758
2020 PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability. Cancer letters 28 33186656
2016 A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis. Cell discovery 28 27807478
2017 BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage. Oxidative medicine and cellular longevity 26 28348719
2004 Parkin and Hsp70 sacked by BAG5. Neuron 23 15603730
2022 Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation. Science translational medicine 20 35044787
2020 miR‑155 inhibition represents a potential valuable regulator in mitigating myocardial hypoxia/reoxygenation injury through targeting BAG5 and MAPK/JNK signaling. Molecular medicine reports 20 31922242
2020 BAG5 promotes invasion of papillary thyroid cancer cells via upregulation of fibronectin 1 at the translational level. Biochimica et biophysica acta. Molecular cell research 20 32275930
2002 Toxoplasma gondii: in vivo expression of BAG-5 and cyst formation is independent of TNF p55 receptor and inducible nitric oxide synthase functions. Microbes and infection 20 11909735
2021 Circ_0008305-mediated miR-660/BAG5 axis contributes to hepatocellular carcinoma tumorigenesis. Cancer medicine 16 33481351
2024 BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly. EMBO reports 15 38454159
2020 Stress-induced p53 drives BAG5 cochaperone expression to control α-synuclein aggregation in Parkinson's disease. Aging 15 33085644
2014 Bag5 protects neuronal cells from amyloid β-induced cell death. Journal of molecular neuroscience : MN 14 25367796
2013 BAG5 regulates PTEN stability in MCF-7 cell line. BMB reports 14 24148769
2012 Protective effect of BAG5 on MPP+-induced apoptosis in PC12 cells. Neurological research 13 23146300
2020 MiRNA-429 alleviates ketamine-induced neurotoxicity through targeting BAG5. Environmental toxicology 12 33283947
2014 The BAG2 and BAG5 proteins inhibit the ubiquitination of pathogenic ataxin3-80Q. The International journal of neuroscience 11 25006867
2020 BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62. Frontiers in cell and developmental biology 9 32850835
2021 Implication of BAG5 downregulation in metabolic reprogramming of cisplatin-resistant ovarian cancer cells via mTORC2 signaling pathway. Biochimica et biophysica acta. Molecular cell research 8 34126157
2022 Role of BAG5 in Protein Quality Control: Double-Edged Sword? Frontiers in aging 7 35821856
2021 miR-142-5p regulates lipopolysaccharide-induced bovine epithelial cell proliferation and apoptosis via targeting BAG5. Experimental and therapeutic medicine 7 34707706
2021 miRNA-770-5p expression is upregulated in patients with type 2 diabetes and miRNA-770-5p knockdown protects pancreatic β-cell function via targeting BAG5 expression. Experimental and therapeutic medicine 6 33986829
2021 Lipoxin A4 methyl ester protects PC12 cells from ketamine-induced neurotoxicity via the miR-22/BAG5 pathway. Human & experimental toxicology 6 34670429
2020 Identification of BAG5 from orange-spotted grouper (Epinephelus coioides) involved in viral infection. Developmental and comparative immunology 6 33137395
2022 LncRNA TUG1 Promoted Stabilization of BAG5 by Binding DDX3X to Exacerbate Ketamine-Induced Neurotoxicity. Neurotoxicity research 4 36151390
2023 Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch. International journal of molecular sciences 3 38139359
2010 [Direct interaction between BAG5 protein and Parkin protein]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 3 21131737
2022 Identification of BAG5 as a Potential Biomarker for Parkinson's Disease Patients With R492X PINK1 Mutation. Frontiers in neuroscience 2 35968372
2025 MSTRG.118323.5 targets BAG5 as a miR-200-y sponge to regulate Sertoli cells apoptosis via PI3K/AKT/mTOR pathways of Bactrian camels. International journal of biological macromolecules 1 40945824
2024 A novel BAG5 variant impairs the ER stress response pathway, causing dilated cardiomyopathy and arrhythmia. Scientific reports 1 38796549
2024 Beta-amyloid protein regulates miR-15a and activates Bag5 to influence neuronal apoptosis in Alzheimer's disease. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 1 39788499
2026 HSPA1A-BAG5 chaperone complex promotes spermatogenesis by driving ubiquitination-mediated degradation of ATF2. Tissue & cell 0 41558067
2025 Male germ cells with Bag5 deficiency show reduced spermiogenesis and exchange of basic nuclear proteins. Cellular and molecular life sciences : CMLS 0 39992433
2025 Mechanistic insights into promotion of non-small cell lung cancer by BAG5 using integrative multi-omics approaches. Frontiers in immunology 0 40787462

Missed literature

Know a paper Affinage missed for BAG5? Flag it for the maintainers and the community.

No submissions yet.