Affinage

BAG5

BAG family molecular chaperone regulator 5 · UniProt Q9UL15

Length
447 aa
Mass
51.2 kDa
Annotated
2026-04-28
45 papers in source corpus 21 papers cited in narrative 21 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

BAG5 is a multi-BAG-domain co-chaperone that couples nucleotide exchange factor activity on Hsp70-family chaperones to regulation of protein ubiquitination, thereby governing protein quality control, mitophagy, ER stress responses, and cell survival across multiple tissues. Its fifth BAG domain binds the Hsp70 nucleotide-binding domain, disrupts the nucleotide-binding groove, and accelerates ADP–ATP exchange to promote substrate refolding (PMID:20223214), while BAG5 simultaneously inhibits the E3 ubiquitin ligases Parkin, CHIP, and MDM2, stabilizing substrates such as α-synuclein, mutant p53, PINK1, PTEN, and Akt (PMID:15603737, PMID:21358815, PMID:27807478, PMID:38139359). In cardiomyocytes BAG5 localizes to junctional membrane complexes and the ER, where it sustains calcium handling and the unfolded protein response; loss-of-function mutations cause dilated cardiomyopathy in mice (PMID:35044787, PMID:38796549). In spermatids BAG5 partners with HSPA8 and HSPA2 to fold head–tail coupling apparatus components, and its deficiency causes acephalic spermatozoa and male infertility (PMID:38454159, PMID:39992433).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2004 High

    Establishing BAG5 as a dual inhibitor of Hsp70 refolding and Parkin E3 ligase activity answered how a single co-chaperone could simultaneously impair both chaperone-mediated refolding and ubiquitin-proteasome clearance, providing the first mechanistic link between BAG5 and dopaminergic neurodegeneration.

    Evidence Co-IP, in vitro ubiquitin ligase and chaperone refolding assays, and in vivo dopaminergic neuron death model with BAG5 mutant rescue in rat

    PMID:15603737

    Open questions at the time
    • The specific BAG domain(s) responsible for Parkin inhibition were not mapped
    • No structural basis for the Hsp70-inhibitory versus E3-inhibitory activities
    • Relevance to endogenous Parkinson's disease pathology in humans untested
  2. 2010 High

    The crystal structure of BAG5's fifth BAG domain bound to the Hsp70 NBD resolved the paradox of how BAG5 could both inhibit and stimulate Hsp70, revealing it acts as a bona fide nucleotide exchange factor that accelerates ADP release.

    Evidence X-ray crystal structure of BD5–NBD complex, nucleotide-binding affinity and chaperone refolding assays

    PMID:20223214

    Open questions at the time
    • Roles of BAG domains 1–4 in Hsp70 regulation remain structurally uncharacterized
    • Whether all five BAG domains engage Hsp70 simultaneously or sequentially is unknown
  3. 2011 High

    Demonstrating that BAG5 inhibits CHIP E3 ligase activity through an Hsp70-bridged ternary complex and thereby blocks α-synuclein ubiquitination expanded BAG5's E3-inhibitory repertoire beyond Parkin and provided a mechanism for α-synuclein oligomer accumulation.

    Evidence Co-IP from mouse brain, in vitro ubiquitination assay, and live-cell protein-fragment complementation assay for α-synuclein oligomerization

    PMID:21358815

    Open questions at the time
    • Whether BAG5-CHIP inhibition occurs through direct binding or solely via Hsp70 bridging was not resolved
    • In vivo relevance to Lewy body formation not demonstrated
  4. 2013 Medium

    Discovery of BAG5 interaction with GRP78/BiP and its ER relocalization during ER stress established a second chaperone partnership and a cytoprotective role in the unfolded protein response, extending BAG5 function beyond cytosolic Hsp70.

    Evidence Co-IP, ATPase assay, subcellular fractionation, siRNA knockdown/overexpression with apoptosis readouts in cancer cells and cardiomyocytes

    PMID:23448667 PMID:26729625

    Open questions at the time
    • Whether BAG5 acts as a nucleotide exchange factor for GRP78 analogous to its role with Hsp70 was not structurally tested
    • Upstream signals governing BAG5 ER translocation are unknown
  5. 2014 Medium

    Identification of BAG5 as a stabilizer of PINK1 via inhibition of its ubiquitination, and separately of pathogenic ataxin-3, broadened the substrate repertoire of BAG5-dependent E3 ligase inhibition to additional neurodegenerative disease proteins.

    Evidence Yeast two-hybrid, GST pull-down, ubiquitination assay, mitochondrial dysfunction rescue (PINK1); co-IF and ubiquitination western blot (ataxin-3)

    PMID:24475098 PMID:25006867

    Open questions at the time
    • Which E3 ligase(s) mediate PINK1 ubiquitination inhibited by BAG5 was not identified
    • Ataxin-3 stabilization data limited to co-IF without detailed mechanism
  6. 2016 Medium

    Showing that BAG5 stabilizes mutant p53 by inhibiting MDM2- and CHIP-mediated ubiquitination linked BAG5's co-chaperone/E3-inhibitory mechanism to oncogenic gain-of-function and chemoresistance, extending its relevance to cancer.

    Evidence Co-IP, ubiquitination and protein half-life assays, proliferation/migration/tumor growth assays with knockdown and overexpression

    PMID:27807478

    Open questions at the time
    • Whether BAG5 directly contacts MDM2 or only acts via Hsp70 bridging is unresolved
    • In vivo tumor model limited to xenograft; genetic cancer models lacking
  7. 2019 Medium

    Live-cell imaging revealed that BAG5 impairs Parkin-dependent mitophagy by blocking Parkin recruitment to damaged mitochondria while paradoxically enhancing Parkin-mediated Mcl-1 degradation during severe stress, clarifying BAG5's role as a switch between protective and pro-death mitochondrial quality control.

    Evidence Live-cell mitophagy flux imaging, lysosomal colocalization, Mcl-1 degradation and cell death assays with BAG5 overexpression/knockdown

    PMID:31787745

    Open questions at the time
    • Molecular basis for the switch between Parkin inhibition and Mcl-1 degradation facilitation is unknown
    • Whether BAG5 directly modulates Parkin's mitochondrial translocation or acts indirectly through Hsp70 was not distinguished
  8. 2020 Medium

    Multiple studies in 2020 connected BAG5 to autophagy via p62/SQSTM1 interaction, to p53-mediated transcriptional induction of BAG5 driving α-synuclein aggregation, and to PRMT6-dependent arginine methylation that regulates HSC70 stability, revealing upstream regulators and downstream effector complexity.

    Evidence ChIP for p53 binding to BAG5 promoter and co-IP from PD patient brain (p53–BAG5–α-syn); co-IP and α-syn oligomerization assay (p62); co-IP, methylation assay, and autophagic flux assay (PRMT6)

    PMID:32850835 PMID:33085644 PMID:33186656

    Open questions at the time
    • Functional significance of BAG5 methylation on its co-chaperone and E3-inhibitory activities not tested
    • p62 interaction lacks domain mapping
    • Whether p53-driven BAG5 induction operates in vivo in PD brain is correlative
  9. 2022 High

    A knock-in mouse model demonstrated that BAG5 loss-of-function causes dilated cardiomyopathy with disrupted junctional membrane complex structure and calcium handling defects, rescued by AAV9 gene delivery, establishing BAG5 as essential for cardiac homeostasis.

    Evidence Knock-in mouse, immunocytochemistry, calcium handling assay, AAV9 rescue, nucleotide exchange assay

    PMID:35044787

    Open questions at the time
    • Identity of the specific JMC client proteins folded by BAG5-HSC70 in cardiomyocytes was not defined
    • Whether human cardiomyopathy patients carry BAG5 mutations remains unestablished
  10. 2023 Medium

    Mapping the BAG5-Akt interaction to the BD1-BD2 linker and showing that BAG5 switches Akt from monoubiquitination to polyubiquitination-mediated degradation established BAG5 as a regulator of growth factor signaling through ubiquitin-chain editing.

    Evidence Co-IP, ubiquitination assay, phosphorylation assay, domain-mapping mutagenesis, Akt stability readouts

    PMID:38139359

    Open questions at the time
    • The E3 ligase catalyzing Akt polyubiquitination in the BAG5-Hsp70 context was not identified
    • Physiological contexts in which this switch operates in vivo are unexplored
  11. 2024 High

    BAG5 knockout mice revealed that BAG5 partners with HSPA8 in spermatids to fold SPATA6 and other head–tail coupling apparatus components; deficiency causes acephalic spermatozoa and male infertility, and also impairs the cardiac ER stress response under tunicamycin challenge.

    Evidence BAG5 KO mice, co-IP, in vitro chaperone substrate affinity assay (spermatid); tunicamycin challenge, echocardiography, TUNEL assay (cardiac)

    PMID:38454159 PMID:38796549

    Open questions at the time
    • Whether BAG5's NEF activity or its E3-inhibitory activity is the critical function in spermatogenesis is unknown
    • The specific ER-stress clients stabilized by BAG5 in cardiomyocytes remain unidentified
  12. 2025 High

    Interaction with testis-specific HSPA2 and RNA-seq of BAG5-deficient testis showed that BAG5 sustains transition protein and protamine transcription and chromatin condensation, revealing a role beyond protein folding in spermatid gene regulation.

    Evidence IP-MS, co-IP, RNA-seq of Bag5-KO testis, KO mouse phenotyping

    PMID:39992433 PMID:41558067

    Open questions at the time
    • Mechanism by which a co-chaperone influences transcription of TNPs/PRMs is not defined
    • Whether BAG5-HSPA2 directly regulates transcription factors or acts through protein stability is unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • Major open questions include: (1) how BAG5's five BAG domains are coordinately or selectively engaged with different Hsp70-family members and E3 ligases; (2) whether BAG5's co-chaperone and E3-inhibitory functions are separable in vivo; (3) whether human BAG5 mutations cause cardiomyopathy or infertility.
  • No full-length BAG5 structure exists
  • No human genetic disease association has been confirmed
  • Relative contribution of NEF vs. E3-inhibitory activity to each tissue-specific phenotype is untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 5 GO:0044183 protein folding chaperone 3 GO:0140657 ATP-dependent activity 2
Localization
GO:0005829 cytosol 4 GO:0005783 endoplasmic reticulum 3 GO:0005886 plasma membrane 1
Pathway
R-HSA-392499 Metabolism of proteins 6 R-HSA-5357801 Programmed Cell Death 3 R-HSA-8953897 Cellular responses to stimuli 3 R-HSA-9612973 Autophagy 3 R-HSA-1474165 Reproduction 2
Partners
AKT1CHIPGRP78HSPA1AHSPA2HSPA8PINK1PRKN
Complex memberships
BAG5-CHIP-Hsp70-α-synuclein complexBAG5-GRP78 ER chaperone complexBAG5-Hsp70/HSC70 co-chaperone complex

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 BAG5 directly interacts with parkin (E3 ubiquitin ligase) and Hsp70, inhibiting both parkin E3 ubiquitin ligase activity and Hsp70-mediated refolding of misfolded proteins; BAG5 also enhances parkin sequestration within protein aggregates and mitigates parkin-dependent preservation of proteasome function, thereby enhancing dopaminergic neuron death in vivo Co-immunoprecipitation, in vitro ubiquitin ligase assay, in vitro chaperone refolding assay, in vivo dopaminergic neuron death model with BAG5 mutant rescue Neuron High 15603737
2010 The fifth BAG domain (BD5) of BAG5 is responsible for interaction with the nucleotide-binding domain (NBD) of Hsp70; BD5 binding induces conformational changes in the NBD that disrupt the nucleotide-binding groove, reduce NBD affinity for ADP, and accelerate ADP-ATP exchange, thereby functioning as a nucleotide exchange factor that enhances Hsp70-mediated protein refolding Crystal structure of BD5–NBD complex, in vitro nucleotide-binding affinity assay, in vitro chaperone refolding assay Structure High 20223214
2011 BAG5 exists in a complex with CHIP and α-synuclein in brain, bridged by Hsp70 binding to the TPR domain of CHIP and the BAG domains of BAG5; this Hsp70-mediated association of BAG5 with CHIP inhibits CHIP E3 ubiquitin ligase activity, reduces CHIP-mediated ubiquitinylation of α-synuclein, and consequently increases α-synuclein oligomerization Co-immunoprecipitation from brain tissue, in vitro ubiquitination assay, luciferase-based protein-fragment complementation assay of α-synuclein oligomerization in live cells PloS one High 21358815
2014 BAG5 directly interacts with PINK1 (identified by yeast two-hybrid and pull-down), stabilizes PINK1 by decreasing its ubiquitination, and rescues MPP+- and rotenone-induced mitochondrial dysfunction by upregulating PINK1 in vitro Yeast two-hybrid, GST pull-down, ubiquitination assay, mitochondrial dysfunction rescue assay in cell culture PloS one Medium 24475098
2013 BAG5 interacts with the ER-resident chaperone GRP78/BiP, enhances its ATPase activity, relocates from the cytoplasm to the ER during ER stress, and inhibits ER stress-induced apoptosis by suppressing PERK-eIF2-ATF4 activity while enhancing the IRE1-Xbp1 axis of the unfolded protein response Co-immunoprecipitation, ATPase activity assay, subcellular fractionation/localization, siRNA knockdown and overexpression with apoptosis readouts BMC cancer Medium 23448667
2016 BAG5 interacts with mutant p53 proteins and protects them from ubiquitination and proteasomal degradation mediated by E3 ubiquitin ligases MDM2 and CHIP, thereby promoting mutant p53 accumulation and gain-of-function activities including increased cell proliferation, tumor growth, migration, and chemoresistance Co-immunoprecipitation, ubiquitination assay, protein stability/half-life assay, cell proliferation/migration/tumor growth assays with knockdown and overexpression Cell discovery Medium 27807478
2019 BAG5 impairs Parkin-dependent mitophagy by suppressing Parkin recruitment to damaged mitochondria and reducing movement of damaged mitochondria into lysosomes; BAG5 also enhances Parkin-mediated Mcl-1 degradation and cell death following severe mitochondrial insult, suggesting BAG5 regulates the bi-modal protective/pro-death activity of Parkin Live-cell imaging of mitophagy flux, mitochondrial recruitment assay, lysosomal colocalization assay, Mcl-1 degradation assay, cell death assay with BAG5 overexpression/knockdown Cell death & disease Medium 31787745
2017 BAG5 interacts with DJ-1 (co-immunoprecipitation and immunofluorescence), decreases DJ-1 stability, and weakens DJ-1's role in mitochondrial protection, possibly by influencing DJ-1 dimerization under stress conditions Co-immunoprecipitation, immunofluorescence co-localization, western blot stability assay Oxidative medicine and cellular longevity Medium 28348719
2013 BAG5, as an inhibitor of CHIP E3 ubiquitin ligase activity, reduces CHIP-mediated ubiquitination of PTEN and thereby stabilizes PTEN protein levels via a ubiquitylation-dependent pathway in MCF-7 cells Co-immunoprecipitation, ubiquitination assay, western blot stability assay with BAG5 overexpression/knockdown BMB reports Low 24148769
2014 BAG2 and BAG5 associate with pathogenic ataxin3-80Q and stabilize it by inhibiting its ubiquitination, as shown by western blotting and co-immunofluorescence Co-immunofluorescence, western blot ubiquitination assay The International journal of neuroscience Low 25006867
2020 BAG5 interacts with p62/sequestosome-1 (SQSTM1), regulates levels and subcellular distribution of p62, and promotes pathogenic α-synuclein oligomer formation, bridging the chaperone network to autophagy-mediated protein degradation Co-immunoprecipitation, immunofluorescence, α-synuclein oligomerization assay with BAG5 overexpression/knockdown Frontiers in cell and developmental biology Low 32850835
2020 Stress-induced p53 binds directly to the BAG5 promoter to stimulate BAG5 transcription; induced BAG5 then binds α-synuclein and Hsp70 in cell cultures and brain lysates from PD patients, and BAG5 is required for α-synuclein aggregation in SH-SY5Y cells Chromatin immunoprecipitation (ChIP), co-immunoprecipitation from cell lysates and human brain lysates, α-synuclein aggregation assay with BAG5 knockdown Aging Medium 33085644
2022 BAG5 acts as a nucleotide exchange factor for HSC70, promoting ADP release and activating HSC70-mediated protein folding; BAG5 localizes to junctional membrane complexes (JMCs) in cardiomyocytes; loss-of-function BAG5 mutations cause dilated cardiomyopathy with decreased JMC protein abundance, disrupted JMC structure, and calcium handling abnormalities in mice Knock-in mouse model, immunocytochemistry/subcellular localization, calcium handling assay, AAV9 gene rescue, nucleotide exchange assay Science translational medicine High 35044787
2020 PRMT6 physically interacts with and methylates BAG5, enhancing the degradation of BAG5's interacting partner HSC70; PRMT6 deficiency stabilizes BAG5-associated HSC70 and promotes autophagy induction in hepatocellular carcinoma cells under stress Co-immunoprecipitation, methylation assay, HSC70 stability/degradation assay, autophagic flux assay with PRMT6 knockdown Cancer letters Medium 33186656
2023 BAG5 interacts with Akt at the linker region between the first and second BAG domains; Akt phosphorylates BAG5's first BAG domain; BAG5 together with Hsp70 switches Akt from monoubiquitination to polyubiquitination and promotes Akt degradation; the BAG5-Akt complex forms under serum starvation and dissociates upon HGF stimulation coincident with BAG5 phosphorylation; BAG5 knockdown attenuates Akt degradation and facilitates Akt activation Co-immunoprecipitation, ubiquitination assay, phosphorylation assay, domain-mapping mutagenesis, BAG5 knockdown/overexpression with Akt stability and activation readouts International journal of molecular sciences Medium 38139359
2024 BAG5 forms a complex with HSPA8 in spermatids and promotes folding of SPATA6 (an HTCA component) by enhancing HSPA8's affinity for substrate proteins; BAG5 deficiency causes misfolding of SPATA6, MYO5A, MYL6, DYNLT1, DCTN1, and DNAL1, leading to abnormal HTCA assembly, acephalic spermatozoa syndrome, and male infertility Co-immunoprecipitation, in vivo BAG5 knockout mice, in vitro chaperone substrate affinity assay, immunofluorescence localization EMBO reports High 38454159
2025 BAG5 interacts with HSPA2 (a testis-specific HSP70 family member) in male germ cells; BAG5 deficiency reduces HSPA2 levels, impairs transcription of transition proteins (TNPs) and protamines (PRMs), causes sperm head deformity, chromatin condensation failure, and massive germ cell apoptosis, resulting in male infertility Immunoprecipitation-mass spectrometry, co-immunoprecipitation, RNA-sequencing of Bag5-deficient testis, Bag5 knockout mice, western blot Cellular and molecular life sciences High 39992433
2026 BAG5 is a primary interactor of HSPA1A; the HSPA1A-BAG5 complex promotes ubiquitination-mediated degradation of ATF2, thereby downregulating apoptotic signaling in spermatogenic cells Immunoprecipitation-mass spectrometry, co-immunoprecipitation, ubiquitination assay, overexpression/knockdown with apoptosis readouts, in vivo HSPA1A inhibition mouse model Tissue & cell Medium 41558067
2016 BAG5 localizes to the ER during ER stress in cardiomyocytes, modulates GRP78 protein stability, reduces ER stress, and protects cardiomyocytes from ER stress-induced apoptosis; siRNA-mediated knockdown of BAG5 causes cell death and decreased cellular viability Subcellular fractionation/localization, adenoviral overexpression, siRNA knockdown, cell viability and apoptosis assays Journal of cellular biochemistry Medium 26729625
2020 BAG5 promotes invasion of papillary thyroid cancer cells by upregulating fibronectin 1 (FN1) at the translational level through suppression of miR-144-3p, which targets the 3'UTR of FN1 transcript BAG5 overexpression/knockdown, migration/invasion assays, western blot, miR-144-3p luciferase reporter assay, translational regulation assay Biochimica et biophysica acta. Molecular cell research Medium 32275930
2024 A BAG5 loss-of-function variant (c.444_445delGA) impairs the ER stress response in cardiomyocytes; homozygous Bag5 knockout mice treated with tunicamycin show significantly reduced cardiac function and increased apoptotic cells, while Bag5-deficient male mice exhibit arrhythmia under stress, establishing BAG5 as necessary for the ER stress response in the heart Bag5 knock-in mouse model, tunicamycin (ER stress) challenge, echocardiography, TUNEL apoptosis assay, arrhythmia monitoring Scientific reports Medium 38796549

Source papers

Stage 0 corpus · 45 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. Neuron 173 15603737
2011 Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5). PloS one 123 21358815
1996 An immunohistochemical method for detecting bradyzoite antigen (BAG5) in Toxoplasma gondii-infected tissues cross-reacts with a Neospora caninum bradyzoite antigen. The Journal of parasitology 111 8604117
2010 The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange. Structure (London, England : 1993) 72 20223214
2016 CaM/BAG5/Hsc70 signaling complex dynamically regulates leaf senescence. Scientific reports 52 27539741
2016 GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes From ER Stress-Induced Apoptosis. Journal of cellular biochemistry 51 26729625
2013 Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis. BMC cancer 51 23448667
2014 BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. PloS one 48 24475098
2016 MicroRNA-127-3p acts as a tumor suppressor in epithelial ovarian cancer by regulating the BAG5 gene. Oncology reports 44 27571744
2019 Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death. Cell death & disease 40 31787745
2020 miR-155 inhibits mitophagy through suppression of BAG5, a partner protein of PINK1. Biochemical and biophysical research communications 31 31948758
2016 A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis. Cell discovery 28 27807478
2020 PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability. Cancer letters 27 33186656
2017 BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage. Oxidative medicine and cellular longevity 26 28348719
2004 Parkin and Hsp70 sacked by BAG5. Neuron 23 15603730
2022 Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation. Science translational medicine 20 35044787
2020 miR‑155 inhibition represents a potential valuable regulator in mitigating myocardial hypoxia/reoxygenation injury through targeting BAG5 and MAPK/JNK signaling. Molecular medicine reports 20 31922242
2020 BAG5 promotes invasion of papillary thyroid cancer cells via upregulation of fibronectin 1 at the translational level. Biochimica et biophysica acta. Molecular cell research 20 32275930
2002 Toxoplasma gondii: in vivo expression of BAG-5 and cyst formation is independent of TNF p55 receptor and inducible nitric oxide synthase functions. Microbes and infection 20 11909735
2021 Circ_0008305-mediated miR-660/BAG5 axis contributes to hepatocellular carcinoma tumorigenesis. Cancer medicine 16 33481351
2020 Stress-induced p53 drives BAG5 cochaperone expression to control α-synuclein aggregation in Parkinson's disease. Aging 15 33085644
2014 Bag5 protects neuronal cells from amyloid β-induced cell death. Journal of molecular neuroscience : MN 14 25367796
2013 BAG5 regulates PTEN stability in MCF-7 cell line. BMB reports 14 24148769
2024 BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly. EMBO reports 13 38454159
2012 Protective effect of BAG5 on MPP+-induced apoptosis in PC12 cells. Neurological research 13 23146300
2020 MiRNA-429 alleviates ketamine-induced neurotoxicity through targeting BAG5. Environmental toxicology 12 33283947
2014 The BAG2 and BAG5 proteins inhibit the ubiquitination of pathogenic ataxin3-80Q. The International journal of neuroscience 11 25006867
2020 BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62. Frontiers in cell and developmental biology 9 32850835
2022 Role of BAG5 in Protein Quality Control: Double-Edged Sword? Frontiers in aging 7 35821856
2021 Implication of BAG5 downregulation in metabolic reprogramming of cisplatin-resistant ovarian cancer cells via mTORC2 signaling pathway. Biochimica et biophysica acta. Molecular cell research 7 34126157
2021 miR-142-5p regulates lipopolysaccharide-induced bovine epithelial cell proliferation and apoptosis via targeting BAG5. Experimental and therapeutic medicine 7 34707706
2021 Lipoxin A4 methyl ester protects PC12 cells from ketamine-induced neurotoxicity via the miR-22/BAG5 pathway. Human & experimental toxicology 6 34670429
2020 Identification of BAG5 from orange-spotted grouper (Epinephelus coioides) involved in viral infection. Developmental and comparative immunology 6 33137395
2015 Crystallographic analysis of the Arabidopsis thaliana BAG5-calmodulin protein complex. Acta crystallographica. Section F, Structural biology communications 6 26144232
2021 miRNA-770-5p expression is upregulated in patients with type 2 diabetes and miRNA-770-5p knockdown protects pancreatic β-cell function via targeting BAG5 expression. Experimental and therapeutic medicine 5 33986829
2022 LncRNA TUG1 Promoted Stabilization of BAG5 by Binding DDX3X to Exacerbate Ketamine-Induced Neurotoxicity. Neurotoxicity research 4 36151390
2023 Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch. International journal of molecular sciences 3 38139359
2010 [Direct interaction between BAG5 protein and Parkin protein]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 3 21131737
2022 Identification of BAG5 as a Potential Biomarker for Parkinson's Disease Patients With R492X PINK1 Mutation. Frontiers in neuroscience 2 35968372
2025 MSTRG.118323.5 targets BAG5 as a miR-200-y sponge to regulate Sertoli cells apoptosis via PI3K/AKT/mTOR pathways of Bactrian camels. International journal of biological macromolecules 1 40945824
2024 A novel BAG5 variant impairs the ER stress response pathway, causing dilated cardiomyopathy and arrhythmia. Scientific reports 1 38796549
2024 Beta-amyloid protein regulates miR-15a and activates Bag5 to influence neuronal apoptosis in Alzheimer's disease. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 1 39788499
2026 HSPA1A-BAG5 chaperone complex promotes spermatogenesis by driving ubiquitination-mediated degradation of ATF2. Tissue & cell 0 41558067
2025 Male germ cells with Bag5 deficiency show reduced spermiogenesis and exchange of basic nuclear proteins. Cellular and molecular life sciences : CMLS 0 39992433
2025 Mechanistic insights into promotion of non-small cell lung cancer by BAG5 using integrative multi-omics approaches. Frontiers in immunology 0 40787462