Affinage

MCC

Colorectal mutant cancer protein · UniProt P23508

Length
829 aa
Mass
93.0 kDa
Annotated
2026-06-10
100 papers in source corpus 9 papers cited in narrative 9 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MCC (Mutated in Colorectal Cancer) is a cytoplasmic PDZ-binding-motif phosphoprotein that integrates cell-cycle control, cell-cell adhesion, and non-canonical Wnt signaling at epithelial membranes (PMID:8626604, PMID:25183869, PMID:29035389). It was first defined as a 100-kDa phosphoprotein whose phosphorylation rises during the G1-to-S transition, and whose wild-type form blocks serum-induced G1-to-S progression while a colorectal-tumor-derived mutant fails to do so (PMID:8626604). MCC localizes to apical microvilli and lateral cell borders in epithelia and concentrates at the active migratory edge of cells (PMID:10449536, PMID:22480440). Through its C-terminal PDZ-binding motif it engages the Scribble polarity protein, and Ser828 phosphorylation at the -1 position regulates a MCC-Scribble-Myosin-IIB complex that governs lamellipodia formation and directed migration (PMID:19555689, PMID:22480440); crystallography of Scribble PDZ1 bound to phosphorylated and unphosphorylated MCC shows the phospho-Ser makes no major PDZ contacts, indicating that phosphorylation acts beyond simple affinity tuning (PMID:31317644). MCC restrains Wnt/β-catenin output by two routes: it physically associates with and stabilizes the E-cadherin/β-catenin adhesion complex to maintain epithelial integrity and limit HGF-induced scatter and invasion (PMID:29035389), and it sequesters the β-catenin coactivator DBC1 in the cytoplasm, reducing β-catenin K49 acetylation via SIRT1 to suppress its transcriptional activity (PMID:24824780). In zebrafish gastrulation MCC binds the Vangl2 cytoplasmic tail and acts as an intracellular effector of Wnt5b/Vangl2/Ror2 planar cell polarity signaling upstream of RhoA/JNK during convergence and extension (PMID:25183869). Disease-associated MCC mutations impair both its G1-to-S block and its DBC1/β-catenin repressor function (PMID:8626604, PMID:24824780).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 1996 Medium

    Established that MCC is a cell-cycle-regulated phosphoprotein that actively restrains the G1-to-S transition, and that a tumor-derived mutation abolishes this control.

    Evidence Phosphorylation analysis across synchronized cell cycle plus wild-type versus mutant overexpression in NIH3T3 cells

    PMID:8626604

    Open questions at the time
    • The kinase phosphorylating MCC and the molecular target of its G1-S block were not identified
    • Endogenous loss-of-function consequence not tested
  2. 1999 Medium

    Defined MCC's subcellular and tissue distribution, placing it at apical/lateral epithelial membranes and linking it to differentiation beyond cell-cycle control.

    Evidence Immunohistochemistry and immunoelectron microscopy across mouse epithelia and neuronal cells, plus NGF-induced PC12 differentiation

    PMID:10449536

    Open questions at the time
    • Membrane-targeting mechanism unknown
    • Functional role in differentiation inferred from expression, not perturbation
  3. 2009 Medium

    Identified Scribble as a PDZ-dependent MCC partner and tied MCC to directed epithelial migration, distinguishing its pathway from canonical Rac1/Cdc42/PAK signaling.

    Evidence Yeast two-hybrid, co-IP, colocalization, and siRNA migration assays in T47D cells

    PMID:19555689

    Open questions at the time
    • Downstream effectors of the MCC-Scrib axis in migration not defined
    • Single cell-line context
  4. 2012 Medium

    Mapped Ser828 in the MCC PDZ-binding motif as a phosphorylation switch controlling a MCC-Scrib-Myosin-IIB complex governing lamellipodia formation.

    Evidence Phospho-site mapping, phosphomimetic/phosphodeficient mutagenesis, co-IP, fractionation, and lamellipodia assays

    PMID:22480440

    Open questions at the time
    • Kinase responsible for Ser828 phosphorylation not identified
    • Mechanistic link between PBM phosphorylation and Myosin-IIB cortical accumulation not resolved
  5. 2014 Medium

    Revealed a mechanism by which MCC suppresses β-catenin transcriptional output: cytoplasmic sequestration of DBC1 leading to SIRT1-dependent β-catenin deacetylation.

    Evidence Co-IP, RNAi, fractionation, reporter and acetylation assays, and pharmacological SIRT1 inhibition

    PMID:24824780

    Open questions at the time
    • Whether MCC directly regulates SIRT1 or acts only through DBC1 relocalization not resolved
    • Single-lab biochemistry
  6. 2014 High

    Placed MCC as an intracellular effector of non-canonical Wnt/PCP signaling by demonstrating direct Vangl2 binding and epistasis upstream of RhoA/JNK during convergence and extension.

    Evidence Zebrafish morpholino knockdown, reciprocal overexpression rescue, Mcc-Vangl2 co-IP, and RhoA/JNK epistasis

    PMID:25183869

    Open questions at the time
    • How Mcc transduces Vangl2 engagement to RhoA/JNK activation not defined
    • Morpholino-based knockdown without genetic mutant confirmation
  7. 2017 Medium

    Showed MCC physically stabilizes the E-cadherin/β-catenin adhesion complex and that its loss licenses HGF-driven, Src/Abl-dependent invasion.

    Evidence siRNA knockdown, co-IP, dispase and TEER adhesion assays, organotypic invasion, and dasatinib rescue in HCT116 cells

    PMID:29035389

    Open questions at the time
    • Direct versus indirect nature of the MCC-cadherin association not dissected
    • Mechanism by which MCC loss activates Src/Abl signaling unknown
  8. 2019 High

    Provided structural detail of the MCC-Scribble interface, showing that PBM Ser828 phosphorylation only weakly affects binding affinity, implying a regulatory function beyond simple affinity modulation.

    Evidence Crystal structures of Scribble PDZ1 with phospho- and unphospho-MCC PBM plus affinity measurements across all four Scribble PDZ domains

    PMID:31317644

    Open questions at the time
    • The non-affinity mechanism by which phosphorylation alters MCC function in cells not established
    • Structural basis of MCC-Myosin-IIB coupling not addressed

Open questions

Synthesis pass · forward-looking unresolved questions
  • The kinase(s) controlling MCC's cell-cycle and PBM phosphorylation, and how its adhesion, β-catenin-repressive, and PCP functions are coordinated in a single cell, remain unresolved.
  • No upstream kinase identified for any MCC phosphosite
  • No unified model linking G1-S control, adhesion, DBC1 sequestration, and Wnt/PCP
  • MCC2 paralogue function in vivo uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 2
Localization
GO:0005886 plasma membrane 3 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1500931 Cell-Cell communication 1 R-HSA-1640170 Cell Cycle 1
Partners
CCAR2CDH1CTNNB1EZRMYH10NHERF1SCRIBVANGL2
Complex memberships
E-cadherin/β-catenin complexMCC-Scribble-Myosin-IIB complex

Evidence

Reading pass · 9 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 The MCC protein is a cytoplasmic 100-kDa phosphoprotein whose phosphorylation state changes in a cell cycle-dependent manner (weakly phosphorylated in G0/G1, highly phosphorylated during G1-to-S transition). Overexpression of wild-type MCC blocked serum-induced cell cycle progression from G1 to S phase, whereas a colorectal-tumor-derived mutant MCC failed to block this transition. Specific antibody detection, immunoelectron microscopy, cell cycle synchronization with phosphorylation analysis, overexpression and cell cycle assay in NIH3T3 cells The Journal of Biological Chemistry Medium 8626604
1999 MCC protein localizes on microvilli and in apical cytoplasm in epithelial cells (renal tubule, pancreatic acinar, hepatocytes), at lateral cell borders in colon epithelium, and is associated with plasma membrane and membrane organelles in neuronal cells. MCC expression increases during NGF-induced differentiation of PC12 cells, suggesting a role in cell differentiation in addition to cell cycle regulation. Immunohistochemistry and immunoelectron microscopy in mouse tissues; immunostaining of NGF-treated PC12 cells The journal of histochemistry and cytochemistry Medium 10449536
2009 MCC was identified as a new binding partner for the tumor suppressor Scrib (Scribble). MCC interacts with both Scrib and the NHERF1/NHERF2/Ezrin complex in a PDZ-dependent manner. MCC and Scrib colocalize at the cell membrane. Reduced expression of MCC impairs directed cell migration in T47D epithelial cells, an effect independent of Rac1, Cdc42, and PAK activation. Yeast two-hybrid, co-immunoprecipitation, colocalization imaging, siRNA knockdown with migration assays FEBS letters Medium 19555689
2012 Serine 828 at position -1 of MCC's PDZ-binding motif (PBM) is phosphorylated in vivo. Endogenous MCC localizes at the active migratory edge of cells, where it interacts with Scrib and non-muscle Myosin-IIB. A phosphomimetic MCC-S828D mutation strongly impairs lamellipodia formation and causes accumulation of Myosin-IIB in the membrane cortex fraction, indicating that phosphorylation of the PBM regulates MCC-Scrib-Myosin-IIB complex function in lamellipodia formation. Phosphorylation site identification, phosphomimetic and phosphodeficient mutagenesis, co-immunoprecipitation, subcellular fractionation, lamellipodia formation assays Biochimica et biophysica acta Medium 22480440
2014 MCC interacts with the beta-catenin repressor DBC1 (Deleted in Breast Cancer 1). MCC overexpression relocalizes DBC1 from the nucleus to the cytoplasm, reducing beta-catenin K49 acetylation via a mechanism involving SIRT1. RNAi of DBC1 promotes beta-catenin transcriptional activity, and DBC1 is required for MCC-mediated beta-catenin repression. MCC binds a glutamic-acid-rich region of DBC1 (distinct from the DBC1 Leucine Zipper domain used by all other known DBC1 partners). A disease-associated MCC mutation strongly impairs this beta-catenin repressor function. Co-immunoprecipitation, RNA interference, overexpression, subcellular fractionation, reporter assays, acetylation assays, pharmacological SIRT1 inhibition International journal of cancer Medium 24824780
2014 MCC is a PDZ domain-containing protein required for non-canonical Wnt5b/Vangl2/Ror2 signaling during convergence and extension (CE) in zebrafish gastrulation. Knockdown of mcc produces CE defects similar to loss of vangl2 or wnt5b. Mcc overexpression rescues depletion of wnt5b, vangl2, and ror2. Direct physical interaction between Mcc and the Vangl2 cytoplasmic tail was established biochemically. CE defects in mcc morphants are suppressed by downstream activation of RhoA and JNK, placing Mcc upstream of RhoA/JNK in the Wnt/PCP pathway. Zebrafish morpholino knockdown, overexpression rescue, co-immunoprecipitation (Mcc-Vangl2 interaction), genetic epistasis (RhoA/JNK activation) Development (Cambridge, England) High 25183869
2017 MCC knockdown in HCT116 colon cancer cells reduces E-cadherin protein level, disrupts the E-cadherin/beta-catenin complex, and impairs cell-cell adhesive strength and epithelial integrity. MCC physically interacts with the E-cadherin/beta-catenin complex (established by co-immunoprecipitation). Loss of MCC enhances hepatocyte growth factor-induced cell scatter and tumor cell invasiveness, which is abrogated by the Src/Abl inhibitor dasatinib. siRNA knockdown, co-immunoprecipitation, dispase assay, transepithelial electrical resistance, organotypic invasion assay, pharmacological rescue Oncogene Medium 29035389
2019 Crystal structures of the Scribble PDZ1 domain bound to the unphosphorylated MCC PDZ-binding motif (PBM) and to phosphorylated MCC (phospho-Ser at -1 position) were determined. Scribble PDZ1 and PDZ3 are the major domains interacting with the MCC PBM. Phosphorylation at the -1 Ser position of MCC has only a minor effect on binding affinity to Scribble PDZ domains; the phospho-Ser makes no major contacts with PDZ1 in the structure, suggesting phosphorylation's functional impact extends beyond simple affinity modulation. Crystal structure determination, affinity measurements (ITC or equivalent), systematic binding assays across all four Scribble PDZ domains The FEBS journal High 31317644
2001 A novel MCC paralogue, MCC2, was identified by yeast two-hybrid screening as a binding partner of the PDZ-domain protein AIE-75. MCC2 binds the first PDZ domain of AIE-75 via its C-terminal residues (-DTFL). In contrast, MCC1 (canonical MCC) does not bind AIE-75, indicating distinct interaction profiles for the two paralogues. Yeast two-hybrid screening, interaction domain mapping Gene Low 11311560

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1992 Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers. Proceedings of the National Academy of Sciences of the United States of America 235 1565631
1992 Loss of heterozygosity affecting the p53, Rb, and mcc/apc tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis. Cancer research 166 1346256
2011 APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Nature cell biology 134 21926987
1992 Polymorphic sites within the MCC and APC loci reveal very frequent loss of heterozygosity in human small cell lung cancer. Cancer research 120 1348017
2012 APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex. Nature structural & molecular biology 119 23007861
2011 p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit. Journal of cell science 115 22100920
1997 Tim23, a protein import component of the mitochondrial inner membrane, is required for normal activity of the multiple conductance channel, MCC. The Journal of cell biology 101 9128249
2008 Mono-N-carboxymethyl chitosan (MCC) and N-trimethyl chitosan (TMC) nanoparticles for non-invasive vaccine delivery. International journal of pharmaceutics 100 18662762
1993 Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer. British journal of cancer 94 8318422
1994 Allelic deletions of MCC/APC and p53 are frequent late events in human gastric carcinogenesis. Gastroenterology 91 8194705
2009 Prevalence of MCPyV in Merkel cell carcinoma and non-MCC tumors. Journal of cutaneous pathology 88 19615033
1991 MCC, a candidate familial polyposis gene in 5q.21, shows frequent allele loss in colorectal and lung cancer. Oncogene 80 1656365
2010 Anti-CD22-MCC-DM1: an antibody-drug conjugate with a stable linker for the treatment of non-Hodgkin's lymphoma. Leukemia 76 20596033
2014 BET protein inhibitor JQ1 attenuates Myc-amplified MCC tumor growth in vivo. Cancer research 75 25277525
1993 Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer. International journal of cancer 63 8406987
1999 Effect of ovariectomy and estrogen replacement on cardiovascular disease in heart failure-prone SHHF/Mcc- fa cp rats. Journal of molecular and cellular cardiology 61 10423350
1994 Aberrations of tumor-suppressor genes (p53, apc, mcc and Rb) in esophageal squamous-cell carcinoma. International journal of cancer 60 8150536
2008 Anti-CD22-MCC-DM1 and MC-MMAF conjugates: impact of assay format on pharmacokinetic parameters determination. Bioconjugate chemistry 55 18637680
2006 A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells. Molecular cancer therapeutics 54 16731769
1993 Primary gastric carcinoma cells frequently lose heterozygosity at the APC and MCC genetic loci. Japanese journal of cancer research : Gann 52 8226275
2011 The Wolinella succinogenes mcc gene cluster encodes an unconventional respiratory sulphite reduction system. Molecular microbiology 50 22040142
2020 Plasma Membrane MCC/Eisosome Domains Promote Stress Resistance in Fungi. Microbiology and molecular biology reviews : MMBR 47 32938742
2012 Impact of carboxymethyl cellulose (CMC) and microcrystalline cellulose (MCC) on functional characteristics of emulsified sausages. Meat science 46 23036941
2018 TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC. Nature communications 45 30341343
2019 Role of MCC/Eisosome in Fungal Lipid Homeostasis. Biomolecules 40 31349700
2017 Therapeutic Inhibition of miR-4260 Suppresses Colorectal Cancer via Targeting MCC and SMAD4. Theranostics 40 28638476
1996 MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase. The Journal of biological chemistry 39 8626604
2017 MCC/Eisosomes Regulate Cell Wall Synthesis and Stress Responses in Fungi. Journal of fungi (Basel, Switzerland) 37 29371577
2016 Dual mTOR inhibitor MLN0128 suppresses Merkel cell carcinoma (MCC) xenograft tumor growth. Oncotarget 37 26536665
2016 The mitotic checkpoint complex (MCC): looking back and forth after 15 years. AIMS molecular science 36 28920074
2011 Biodegradable mPEG-b-P(MCC-g-OEI) copolymers for efficient gene delivery. Journal of controlled release : official journal of the Controlled Release Society 34 21457739
2004 Nitric oxide and histamine induce neuronal excitability by blocking background currents in neuron MCC of Aplysia. Journal of neurophysiology 33 14762147
1999 Genomic instability and alterations in Apc, Mcc and Dcc in Hong Kong patients with colorectal carcinoma. International journal of cancer 33 10404094
1998 The new antidiabetic drug MCC-555 acutely sensitizes insulin signaling in isolated cardiomyocytes. Endocrinology 33 9794462
1994 Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 33 8061582
2015 Clinical and dermoscopic features of combined cutaneous squamous cell carcinoma (SCC)/neuroendocrine [Merkel cell] carcinoma (MCC). Journal of the American Academy of Dermatology 32 26433246
2006 Interrogation of genomes by molecular copy-number counting (MCC). Nature methods 31 16721378
1992 Evidence that the MCC-APC gene region in 5q21 is not the site for susceptibility to hereditary nonpolyposis colorectal carcinoma. Cancer research 31 1643645
2016 The Use of Antihypertensive Medication and the Risk of Breast Cancer in a Case-Control Study in a Spanish Population: The MCC-Spain Study. PloS one 30 27508297
1994 Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer. Human molecular genetics 30 8012355
1993 Effects of obesity and hypertension on ventricular myocytes: comparison of cells from adult SHHF/Mcc-cp and JCR:LA-cp rats. Cardiovascular research 30 8386063
2019 S2k guidelines for Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin) - update 2018. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 29 31056838
2003 MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning. Circulation 29 12615799
2016 Ptk7 and Mcc, Unfancied Components in Non-Canonical Wnt Signaling and Cancer. Cancers 27 27438854
2017 'MCC' protein interacts with E-cadherin and β-catenin strengthening cell-cell adhesion of HCT116 colon cancer cells. Oncogene 26 29035389
2009 MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells. FEBS letters 26 19555689
2005 A novel thiazolidinedione MCC-555 down-regulates tumor necrosis factor-alpha-induced expression of vascular cell adhesion molecule-1 in vascular endothelial cells. Atherosclerosis 26 16115476
2004 RWJ-241947 (MCC-555), a unique peroxisome proliferator-activated receptor-gamma ligand with antitumor activity against human prostate cancer in vitro and in beige/nude/ X-linked immunodeficient mice and enhancement of apoptosis in myeloma cells induced by arsenic trioxide. Clinical cancer research : an official journal of the American Association for Cancer Research 26 14977855
1999 Infrequent loss of heterozygosity of APC/MCC and DCC genes in gastric cancer showing DNA microsatellite instability. Journal of clinical pathology 26 10605402
1994 Deletion of chromosome arm 1p in a Merkel cell carcinoma (MCC). Genes, chromosomes & cancer 26 7515664
1997 Molecular analysis and expression of the extracellular lipase of Aeromonas hydrophila MCC-2. Microbiology (Reading, England) 25 9084164
1997 Loss of heterozygosity of APC and MCC genes in oral squamous cell carcinomas in Taiwan. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 25 9250932
1993 Exclusion of APC and MCC as the gene defect in one family with familial juvenile polyposis. Gastroenterology 25 8224634
1991 Frequent loss of heterozygosity at the MCC locus on chromosome 5q21-22 in sporadic colorectal carcinomas. Japanese journal of cancer research : Gann 25 1682292
2014 MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm. International journal of cancer 24 24824780
2014 Microbial Culture Collection (MCC) and International Depositary Authority (IDA) at National Centre for Cell Science, Pune. Indian journal of microbiology 24 25320411
2008 In silico study of kinetochore control, amplification, and inhibition effects in MCC assembly. Bio Systems 24 18675311
2016 Use of non-steroidal anti-inflammatory drugs and risk of breast cancer: The Spanish Multi-Case-control (MCC) study. BMC cancer 23 27542890
2012 MBSJ MCC Young Scientist Award 2010. Recent progress in research on small post-translationally modified peptide signals in plants. Genes to cells : devoted to molecular & cellular mechanisms 23 22212512
1995 High-frequency of loss of expression and allelic deletion of the apc and mcc genes in human prostate-cancer. International journal of oncology 23 21556510
2014 The PDZ domain protein Mcc is a novel effector of non-canonical Wnt signaling during convergence and extension in zebrafish. Development (Cambridge, England) 22 25183869
2012 A peroxisome proliferator-activated receptor ligand MCC-555 imparts anti-proliferative response in pancreatic cancer cells by PPARgamma-independent up-regulation of KLF4. Toxicology and applied pharmacology 22 22750490
2011 Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC). Cell cycle (Georgetown, Tex.) 22 22037211
2014 Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes. Journal of hematology & oncology 21 25200342
2012 The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells. Biochimica et biophysica acta 21 22480440
2002 Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus. Antimicrobial agents and chemotherapy 21 12121939
2023 S2k Guideline - Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin) - Update 2022. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20 36929552
2022 In vitro and in vivo evaluation of probiotic potential and safety assessment of Bacillus coagulans SKB LAB-19 (MCC 0554) in humans and animal healthcare. Regulatory toxicology and pharmacology : RTP 20 35793725
2017 LC-MS/MS method for the simultaneous determination of Lys-MCC-DM1, MCC-DM1 and DM1 as potential intracellular catabolites of the antibody-drug conjugate trastuzumab emtansine (T-DM1). Journal of pharmaceutical and biomedical analysis 20 28131055
2022 Azadirachta indica leaf extract mediated silver nanoparticles impregnated nano composite film (AgNP/MCC/starch/whey protein) for food packaging applications. Environmental research 19 36283439
2022 Kinetochore-catalyzed MCC formation: A structural perspective. IUBMB life 19 36518060
2021 The Combined Effect of Potential Probiotic Bacillus licheniformis MCC 2514 and Bifidobacterium breve NCIM 5671 Towards Anti-inflammatory Activity on HT-29 Cell Lines. Probiotics and antimicrobial proteins 19 34581975
2020 The Clinical Utility of Neuron-Specific Enolase (NSE) Serum Levels as a Biomarker for Merkel Cell Carcinoma (MCC). Annals of surgical oncology 18 32529274
2016 Paraneoplastic syndromes (PNS) associated with Merkel cell carcinoma (MCC): A case series of 8 patients highlighting different clinical manifestations. Journal of the American Academy of Dermatology 18 27177440
2014 Identification of eight novel mutations and transcript analysis of two splicing mutations in Chinese newborns with MCC deficiency. Clinical genetics 18 25382614
1998 Decreased expression of the adenomatous polyposis coli (Apc) and mutated in colorectal cancer (Mcc) genes in mouse lung neoplasia. Molecular carcinogenesis 18 9473770
1993 The putative tumor suppressor gene on chromosome 5q for hepatocellular carcinoma is distinct from the MCC and APC genes. Cancer detection and prevention 18 8402727
2018 Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study. Nutrients 17 30577563
2008 Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways. Molecular cancer therapeutics 17 18790758
2001 Interaction of MCC2, a novel homologue of MCC tumor suppressor, with PDZ-domain Protein AIE-75. Gene 17 11311560
1999 LOH at the APC/MCC gene (5Q21) is frequent in early stages of non-small cell lung cancer. Pathology, research and practice 17 10549031
1993 Cloning and nucleotide sequence of an extracellular alpha-amylase gene from Aeromonas hydrophila MCC-1. Journal of general microbiology 17 8126440
1990 Synergistic effects of male sex and obesity on hepatic insulin dynamics in SHR/Mcc-cp rat. Diabetes 17 2191885
2022 Coordinated regulation of TORC2 signaling by MCC/eisosome-associated proteins, Pil1 and tetraspan membrane proteins during the stress response. Molecular microbiology 16 35383382
2021 In vitro validation studies for adhesion factor and adhesion efficiency of probiotic Bacillus licheniformis MCC 2514 and Bifidobacterium breve NCIM 5671 on HT-29 cell lines. Archives of microbiology 16 33772601
2019 Genomic Insights of Halophilic Planococcus maritimus SAMP MCC 3013 and Detail Investigation of Its Biosurfactant Production. Frontiers in microbiology 16 30863371
2018 Sublichenin, a new subtilin-like lantibiotics of probiotic bacterium Bacillus licheniformis MCC 2512T with antibacterial activity. Microbial pathogenesis 16 30594640
1992 Effects of enalapril and clonidine on glomerular structure, function, and atrial natriuretic peptide receptors in SHHF/Mcc-cp rats. Journal of cardiovascular pharmacology 16 1378131
2020 Sunitinib Versus Sorafenib as Initial Targeted Therapy for mCC-RCC With Favorable/Intermediate Risk: Multicenter Randomized Trial CROSS-J-RCC. Clinical genitourinary cancer 15 32466961
2020 Occupational Heat Exposure and Breast Cancer Risk in the MCC-Spain Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 15 33268491
2019 Structural analysis of phosphorylation-associated interactions of human MCC with Scribble PDZ domains. The FEBS journal 15 31317644
2017 Relationship between drugs affecting the renin-angiotensin system and colorectal cancer: The MCC-Spain study. Preventive medicine 15 28131779
2017 Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint Arrest. Current biology : CB 15 28366744
2017 Efficacy of isolated limb perfusion (ILP) in patients with Merkel cell carcinoma (MCC): A multicenter experience. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 15 28802661
2013 Merkel cell polyomavirus (MCPyV) strains in Japanese merkel cell carcinomas (MCC) are distinct from Caucasian type MCPyVs: genetic variability and phylogeny of MCPyV genomes obtained from Japanese MCPyV-infected MCCs. Virus genes 15 24353025
2018 Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project. BMC cancer 14 29530003
2010 MCC-555-induced NAG-1 expression is mediated in part by KLF4. European journal of pharmacology 14 20385121
2000 Allelic loss involving the tumor suppressor genes APC and MCC and expression of the APC protein in the development of dysplasia and carcinoma in Barrett esophagus. American journal of clinical pathology 14 11338478
1999 Localization of MCC (mutated in colorectal cancer) in various tissues of mice and its involvement in cell differentiation. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 14 10449536
1995 Loss of heterozygosity of APC/MCC gene in differentiated and undifferentiated gastric carcinomas in Taiwan. Cancer letters 14 7585453

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