Affinage

MAP9

Microtubule-associated protein 9 · UniProt Q49MG5

Length
647 aa
Mass
74.2 kDa
Annotated
2026-04-28
68 papers in source corpus 11 papers cited in narrative 12 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MAP9 is a vertebrate-conserved microtubule-associated protein that stabilizes microtubules, organizes the mitotic spindle, maintains ciliary microtubule doublet architecture, and modulates the p53 DNA damage response. Its C-terminal domain directly binds microtubules, and cryo-EM reveals that five helical repeats wrap along the outer surface to staple adjacent protofilaments and prevent depolymerization; this binding mode selectively permits kinesin-3 motility while hindering kinesin-1 (PMID:16049101). During mitosis, sequential phosphorylation by Aurora-A on S625 and by Plk1 on S289 targets MAP9 to centrosomes via the γ-TuRC pathway and is required for bipolar spindle assembly and spindle pole stability (PMID:17925329, PMID:20615875). In cilia, MAP9 localizes exclusively to microtubule doublets in a polyglutamylation-dependent manner, where it maintains B-tubule protofilament number and regulates axonemal motor velocity; after DNA damage, MAP9 interacts with p53 to enhance p300-mediated acetylation and block MDM2-mediated degradation, thereby promoting p53 transcriptional activity (PMID:38159567, PMID:22672907).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 2005 High

    Establishing MAP9 as a bona fide microtubule-associated protein essential for mitosis resolved its molecular identity and showed that it directly binds microtubules and is required for proper spindle formation, cytokinesis, and cell survival.

    Evidence Direct binding assay with purified microtubules, RNAi knockdown, and overexpression in human cells

    PMID:16049101

    Open questions at the time
    • Binding site on the microtubule lattice was unknown
    • No kinase regulation identified
    • Mechanism of spindle defects upon depletion not resolved
  2. 2007 High

    Identification of Aurora-A as the kinase that phosphorylates MAP9 on S625 explained how MAP9 is activated and stabilized for mitotic spindle function, linking its centrosomal targeting to a well-characterized mitotic kinase cascade.

    Evidence In vitro kinase assay, S625E/S625A mutagenesis with RNAi rescue, phosphospecific antibody microinjection in human cells

    PMID:17925329

    Open questions at the time
    • Whether additional kinases regulate MAP9 was unknown
    • Mechanism of proteasome-dependent degradation in absence of Aurora-A not characterized
  3. 2008 Medium

    Cloning of mouse and Xenopus orthologs demonstrated vertebrate conservation of MAP9 function and revealed high expression in brain and testis, broadening MAP9's relevance beyond generic cell division to neuronal and germ-cell biology.

    Evidence cDNA cloning, domain analysis, immunofluorescence in neurons and testis tissue sections across species

    PMID:18782428

    Open questions at the time
    • No loss-of-function data in neurons or testis at this stage
    • Domain-to-function mapping incomplete
  4. 2010 High

    Identification of Plk1-mediated phosphorylation on S289 and placement of MAP9 in the γ-TuRC pathway established a two-kinase sequential regulatory model controlling MAP9 localization and spindle pole stability during mitosis.

    Evidence In vitro Plk1 kinase assay, S289 mutagenesis, γ-TuRC pathway analysis, immunofluorescence in human cells

    PMID:20615875

    Open questions at the time
    • Whether S289 phosphorylation affects microtubule binding affinity was not tested
    • Temporal ordering of Aurora-A versus Plk1 phosphorylation events not fully dissected
  5. 2012 Medium

    Discovery that MAP9 directly interacts with p53 to enhance p300-mediated acetylation and block MDM2-mediated degradation revealed an unexpected non-cytoskeletal function in the DNA damage response, placing MAP9 within the centrosome-p53 regulatory circuit.

    Evidence Co-immunoprecipitation, ubiquitination and acetylation assays, p53 reporter assay after DNA damage induction in human cells

    PMID:22672907

    Open questions at the time
    • Structural basis of the MAP9–p53 interaction not determined
    • Whether this function is centrosome-localized or nucleoplasmic was not resolved
    • No in vivo confirmation in animal models
  6. 2014 Medium

    Zebrafish map9 morpholino knockdown demonstrated that MAP9 is essential for early vertebrate development, controlling epiboly, gastrulation, YSL microtubule integrity, and left-right patterning gene regulation.

    Evidence Morpholino knockdown in zebrafish embryos with phenotypic and gene expression analysis

    PMID:24553125

    Open questions at the time
    • Morpholino off-target effects not fully excluded; genetic null not generated
    • Molecular mechanism linking MAP9 loss to endodermal gene deregulation unclear
  7. 2023 High

    Structural and functional analysis in C. elegans and mammalian systems established MAP9 as a conserved microtubule doublet-specific protein in cilia, where it maintains B-tubule protofilament integrity and regulates axonemal motor velocity in a polyglutamylation-dependent manner.

    Evidence C. elegans genetics and electron microscopy of MTD ultrastructure, in vivo motor velocity measurements, immunofluorescence in worm and mammalian tissues

    PMID:38159567

    Open questions at the time
    • How polyglutamylation mediates MAP9 specificity for doublets versus singlets not structurally resolved
    • Whether ciliary and mitotic functions of MAP9 are mutually exclusive or concurrent is unclear
  8. 2023 Medium

    Demonstration that MAP9 localizes to the basal body of photoreceptor cilia and that combined MAP9/RPGRIP1 deficiency accelerates cone-rod dystrophy established MAP9 as a ciliary disease modifier gene.

    Evidence Immunostaining of canine retinal photoreceptors and cultured cells, comparison of disease progression in single versus double mutant dogs

    PMID:37650070

    Open questions at the time
    • No human patient data linking MAP9 variants to retinal disease
    • Whether MAP9 acts solely at the basal body or along the axoneme in photoreceptors was not resolved
  9. 2025 High

    Cryo-EM structure revealed that MAP9 uses five helical repeats to staple adjacent protofilaments on the microtubule outer surface, explaining its stabilization mechanism and showing that it selectively permits kinesin-3 while hindering kinesin-1 through loop-8 interactions — providing a structural basis for motor selectivity on MAP-decorated tracks.

    Evidence (preprint) Cryo-EM structural determination, in vitro single-molecule kinesin motility assays, siRNA knockdown neurite outgrowth assay

    Open questions at the time
    • Preprint not yet peer reviewed
    • Whether this motor-selective mechanism operates in vivo in neurons or cilia remains to be tested
    • Interplay between MAP9 and other MAPs on the same microtubule lattice not examined

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis of MAP9's dual ciliary and mitotic functions, whether MAP9 variants cause Mendelian disease in humans, how MAP9 coordinates its microtubule-stabilizing and p53-regulatory activities in space and time, and the in vivo relevance of MAP9-mediated kinesin selectivity.
  • No human disease-causing mutations identified
  • No atomic-resolution structure of MAP9 on microtubule doublets
  • In vivo motor selectivity function untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 3 GO:0098772 molecular function regulator activity 2
Localization
GO:0005856 cytoskeleton 4 GO:0005815 microtubule organizing center 3 GO:0005929 cilium 2
Pathway
R-HSA-1640170 Cell Cycle 3 R-HSA-1852241 Organelle biogenesis and maintenance 2 R-HSA-5357801 Programmed Cell Death 1
Partners
AURKAEP300MDM2PLK1TP53TUBGCP2

Evidence

Reading pass · 12 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 MAP9 (ASAP/aster-associated protein) is a human microtubule-associated protein that directly binds purified microtubules via its C-terminal domain. It localizes to microtubules in interphase, associates with the mitotic spindle during mitosis, and localizes to the central body during cytokinesis. Overexpression induces cytoplasmic microtubule bundling and aberrant monopolar spindles; RNAi depletion causes aberrant mitotic spindles, delayed mitotic progression, defective cytokinesis, and cell death. Direct microtubule binding assay with purified microtubules, RNA interference knockdown, overexpression in human cells, live-cell imaging/immunofluorescence Proceedings of the National Academy of Sciences of the United States of America High 16049101
2007 MAP9 is a direct substrate of Aurora-A kinase (AurA); Serine 625 is the major in vivo phosphorylation site. The phosphorylated form localizes to centrosomes from late G2 to telophase and around the midbody during cytokinesis. Aurora-A depletion causes proteasome-dependent degradation of MAP9. Spindle defects caused by MAP9 depletion are rescued by the phosphomimetic S625E mutant but not the non-phosphorylatable S625A mutant; microinjection of S625-phosphospecific antibodies impairs spindle formation and mitosis. In vitro kinase assay, site-directed mutagenesis (S625E/S625A), immunofluorescence with phosphospecific antibodies, RNAi rescue experiments, proteasome inhibitor treatment, microinjection Human molecular genetics High 17925329
2008 MAP9 orthologs are found in vertebrates (mouse and Xenopus cDNAs cloned). The protein contains MAP, MIT-like, and THY domains in its C-terminal part indicative of microtubule interaction, and two main coiled-coil regions. Mouse and Xenopus MAP9 proteins localize to the microtubule network in interphase and to the mitotic spindle during mitosis; overexpression of mouse MAP9 induces mitotic defects similar to those of human MAP9. MAP9 is highly expressed in brain and testis; in testis it localizes to germ cells; in cultured neurons it localizes to the cell body and growing neurites. cDNA cloning, domain analysis, immunofluorescence in cells and tissue sections, in situ hybridization, overexpression BMC genomics Medium 18782428
2010 Polo-like kinase 1 (Plk1) localizes MAP9 to spindle poles via the γ-TuRC-dependent pathway. MAP9 is a novel Plk1 substrate; Serine 289 is the major Plk1 phosphorylation site in vivo. MAP9 phosphorylated on S289 localizes to centrosomes during mitosis but this phosphorylation is not required for Plk1-dependent spindle pole localization. Plk1-mediated phosphorylation of MAP9 on S289 contributes to spindle pole stability in a microtubule-dependent manner. In vitro Plk1 kinase assay, site-directed mutagenesis (S289), immunofluorescence with phosphospecific antibodies, RNAi, γ-TuRC pathway analysis The Journal of biological chemistry High 20615875
2012 Following DNA double-strand break formation, MAP9 directly interacts with and stabilizes p53 by enhancing p300-mediated acetylation of p53 and blocking MDM2-mediated ubiquitination and degradation, leading to increased p53 transcriptional activity. MAP9 is transiently accumulated after DNA damage then degraded upon persistent damage. This places MAP9 in the p300-MDM2-p53 regulatory loop at the centrosome. Co-immunoprecipitation, ubiquitination assay, acetylation assay, p53 reporter transcription assay, siRNA depletion, DNA damage induction (DSBs) Cell cycle (Georgetown, Tex.) Medium 22672907
2014 In zebrafish, map9 is expressed primarily as a maternal gene, associates with the mitotic spindle and centrosomes, and localizes to the microtubule array of the yolk syncytial layer (YSL). Morpholino-mediated depletion of map9 leads to arrest before epiboly completion, destruction of the YSL microtubule network, arrest of epiboly/gastrulation when injected into the nascent YSL, deregulation of genes for endodermal differentiation and left-right patterning, spindle and mitotic defects, and increased apoptosis at low doses. Morpholino knockdown in zebrafish, immunofluorescence, whole-mount in situ hybridization, gene expression analysis Cell cycle (Georgetown, Tex.) Medium 24553125
2016 A genomic deletion spanning ~22 kb in canine MAP9 (including intron 10 and a downstream MAP9 pseudogene) is associated with early onset retinal degeneration in dogs carrying a primary RPGRIP1 mutation, acting as a modifier locus. MAP9 is proposed to associate with α-tubulin in the basal body of the cilium, and the MAP9 deficit is speculated to synergize with RPGRIP1 deficit to cause more severe disease. Target-enriched sequencing, genome assembly correction, association mapping (GWAS), RT-PCR for RNA expression of fusion gene Mammalian genome : official journal of the International Mammalian Genome Society Low 27017229
2019 miR-320a directly targets MAP9 mRNA (validated by dual luciferase reporter assay); MAP9 is negatively regulated by miR-320a. MAP9 knockdown in MC3T3-E1 osteoblast cells reduces cell viability and differentiation and promotes apoptosis, effects that are linked to reduced PI3K/AKT signaling pathway activity. Dual luciferase reporter assay, siRNA knockdown, flow cytometry, western blot (PI3K, p-AKT), MTT assay, rescue assay Experimental and molecular pathology Medium 31301305
2023 MAP9 (C. elegans ortholog MAPH-9) is a microtubule doublet (MTD)-associated protein present during MTD assembly that localizes exclusively to MTDs in cilia, a preference partly mediated by tubulin polyglutamylation. Loss of MAPH-9 causes ultrastructural MTD defects including shortened/squashed B-tubules with reduced protofilament numbers, dysregulated axonemal motor velocity, and perturbed cilia function. Mammalian MAP9 localizes to axonemes in cultured mammalian cells and mouse tissues, indicating a conserved role in supporting MTD structure and regulating ciliary motors. Genetics (C. elegans loss-of-function), electron microscopy (ultrastructure), immunofluorescence (localization in worm and mammalian cells/tissues), in vivo motor velocity measurements, cilia function assays, tubulin polyglutamylation mutants Developmental cell High 38159567
2023 MAP9 localizes to the basal body of primary cilia in canine retinal photoreceptors and cultured cells, and maintains ciliary microtubule axoneme structure. In the canine cone-rod dystrophy model with combined RPGRIP1 and MAP9 mutations, progressive cone photoreceptor degeneration begins earlier than with RPGRIP1 mutation alone, indicating MAP9 plays a role in cilia organization and maintenance that modifies RPGRIP1-associated disease severity. Immunostaining of canine retinal sections and cultured cells, functional and structural analysis of photoreceptor degeneration (histology, ERG), comparison of single vs. double mutant disease progression Frontiers in cellular neuroscience Medium 37650070
2022 MAP9 knockdown in bladder cancer cells causes G1/S cell cycle arrest in vitro and slows tumor growth in vivo. MAP9 silencing attenuates cell migration and invasion, decreases G1/S cell cycle-related gene expression and EMT markers. Co-immunoprecipitation and rescue assays identified the TGF-β1 pathway as a downstream mediator by which MAP9 regulates G1/S genes and EMT. shRNA stable knockdown, Co-immunoprecipitation, western blot, xenograft mouse model, migration/invasion assays, rescue experiments Journal of oncology Medium 35656338
2025 Cryo-EM structure shows MAP9 binds along the outer surface of microtubules as a long alpha helix using five consecutive repeats that wrap around the microtubule and staple adjacent protofilaments, a binding mode distinct from other MAPs. MAP9 stabilizes microtubules and prevents depolymerization. MAP9 knockdown abolishes neurite outgrowth in neurons. MAP9 selectively permits kinesin-3 motility while hindering kinesin-1 through interactions with a divergent loop-8 of their motor domains. Cryo-electron microscopy (structural determination), siRNA knockdown (neurite outgrowth assay), in vitro single-molecule motility assays with kinesin-1 and kinesin-3, microtubule depolymerization assay bioRxivpreprint High

Source papers

Stage 0 corpus · 68 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2020 ASAP: assemble species by automatic partitioning. Molecular ecology resources 673 33058550
2014 The evolutionary neuroscience of musical beat perception: the Action Simulation for Auditory Prediction (ASAP) hypothesis. Frontiers in systems neuroscience 291 24860439
2021 Micropeptide ASAP encoded by LINC00467 promotes colorectal cancer progression by directly modulating ATP synthase activity. The Journal of clinical investigation 131 34591791
2003 ASAP, a novel protein complex involved in RNA processing and apoptosis. Molecular and cellular biology 118 12665594
2003 ASAP: the Alternative Splicing Annotation Project. Nucleic acids research 117 12519958
2017 ASAP: a web-based platform for the analysis and interactive visualization of single-cell RNA-seq data. Bioinformatics (Oxford, England) 95 28541377
2006 The ASAP II database: analysis and comparative genomics of alternative splicing in 15 animal species. Nucleic acids research 90 17108355
2004 Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus and the spectrum of the acute syndrome of apoptotic pan-epidermolysis (ASAP): a case report, concept review and proposal for new classification of lupus erythematosus vesiculobullous skin lesions. Lupus 89 15645750
2012 The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex. Nature structural & molecular biology 77 22388736
2007 Analysis of the inhibition of the ergosterol pathway in fungi using the atmospheric solids analysis probe (ASAP) method. Journal of the American Society for Mass Spectrometry 56 17482834
2024 Remission induction versus immediate allogeneic haematopoietic stem cell transplantation for patients with relapsed or poor responsive acute myeloid leukaemia (ASAP): a randomised, open-label, phase 3, non-inferiority trial. The Lancet. Haematology 46 38583455
2005 ASAP: amplification, sequencing & annotation of plastomes. BMC genomics 40 16336644
2002 The Avoid Stroke as Soon as Possible (ASAP) general practice stroke audit. The Medical journal of Australia 40 12013322
2009 Discovery of 4-aryl-4H-chromenes as potent apoptosis inducers using a cell- and caspase-based Anti-cancer Screening Apoptosis Program (ASAP): SAR studies and the identification of novel vascular disrupting agents. Anti-cancer agents in medicinal chemistry 39 19442043
2007 ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A: phosphorylation on Ser625 is essential to spindle formation and mitosis. Human molecular genetics 39 17925329
2005 ASAP, a human microtubule-associated protein required for bipolar spindle assembly and cytokinesis. Proceedings of the National Academy of Sciences of the United States of America 37 16049101
2008 Effects of soy protein isolate consumption on prostate cancer biomarkers in men with HGPIN, ASAP, and low-grade prostate cancer. Nutrition and cancer 35 18444130
2008 Asap: a framework for over-representation statistics for transcription factor binding sites. PloS one 33 18286180
2016 Canine genome assembly correction facilitates identification of a MAP9 deletion as a potential age of onset modifier for RPGRIP1-associated canine retinal degeneration. Mammalian genome : official journal of the International Mammalian Genome Society 28 27017229
2011 Different levels of the Tripartite motif protein, Anomalies in sensory axon patterning (Asap), regulate distinct axonal projections of Drosophila sensory neurons. Proceedings of the National Academy of Sciences of the United States of America 28 22084112
2022 ASAP Score versus GALAD Score for detection of hepatitis C-related hepatocellular carcinoma: A multicenter case-control analysis. Frontiers in oncology 27 36263214
2006 RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses. Nucleic acids research 22 16870721
2019 Quantitative Proteomics Reveals a Role for SERINE/ARGININE-Rich 45 in Regulating RNA Metabolism and Modulating Transcriptional Suppression via the ASAP Complex in Arabidopsis thaliana. Frontiers in plant science 20 31608083
2020 ASAP 2020 update: an open, scalable and interactive web-based portal for (single-cell) omics analyses. Nucleic acids research 19 32449934
2019 MiR-320a was highly expressed in postmenopausal osteoporosis and acts as a negative regulator in MC3T3E1 cells by reducing MAP9 and inhibiting PI3K/AKT signaling pathway. Experimental and molecular pathology 19 31301305
2010 Plk1 regulates both ASAP localization and its role in spindle pole integrity. The Journal of biological chemistry 19 20615875
2008 Gene organization, evolution and expression of the microtubule-associated protein ASAP (MAP9). BMC genomics 19 18782428
2014 Microtubule-associated protein 9 (Map9/Asap) is required for the early steps of zebrafish development. Cell cycle (Georgetown, Tex.) 18 24553125
2008 Automated simultaneous analysis phylogenetics (ASAP): an enabling tool for phlyogenomics. BMC bioinformatics 17 18282301
2016 The Arf GAP Asap promotes Arf1 function at the Golgi for cleavage furrow biosynthesis in Drosophila. Molecular biology of the cell 16 27535433
2014 Expression of the microtubule-associated protein MAP9/ASAP and its partners AURKA and PLK1 in colorectal and breast cancers. Disease markers 15 24876664
2023 MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement. Developmental cell 14 38159567
2022 Population Pharmacokinetics and Dosing Simulations of Ceftriaxone in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation (An ASAP ECMO Study). Clinical pharmacokinetics 14 35253107
2016 ASAP: a machine learning framework for local protein properties. Database : the journal of biological databases and curation 14 27694209
2023 Comparison between models for detecting hepatocellular carcinoma in patients with chronic liver diseases of various etiologies: ASAP score versus GALAD score. Hepatobiliary & pancreatic diseases international : HBPD INT 12 38199909
2018 Excitation wavelength optimization improves photostability of ASAP-family GEVIs. Molecular brain 12 29866136
2023 ASAP─Automated Sonication-Free Acid-Assisted Proteomes─from Cells and FFPE Tissues. Analytical chemistry 11 36724070
2018 ASAP - A Webserver for Immunoglobulin-Sequencing Analysis Pipeline. Frontiers in immunology 11 30105017
2012 Induction of ASAP (MAP9) contributes to p53 stabilization in response to DNA damage. Cell cycle (Georgetown, Tex.) 10 22672907
2023 High PIVKA-II level and ASAP score predict 1-year risk of hepatocellular carcinoma in non-cirrhotic chronic hepatitis B patients. American journal of cancer research 8 37424806
2016 Automated Sanger Analysis Pipeline (ASAP): A Tool for Rapidly Analyzing Sanger Sequencing Data with Minimum User Interference. Journal of biomolecular techniques : JBT 8 27790076
2023 Molecular characterization of MAP9 in the photoreceptor sensory cilia as a modifier in canine RPGRIP1-associated cone-rod dystrophy. Frontiers in cellular neuroscience 7 37650070
2012 Prostate Cancer Chemoprevention Targeting Men with High-Grade Prostatic Intraepithelial Neoplasia (HGPIN) and Atypical Small Acinar Proliferation (ASAP): Model for Trial Design and Outcome Measures. Journal of clinical trials 7 24533253
2025 Comparative performance of the GAAD and ASAP scores in predicting early-stage hepatocellular carcinoma. Gastroenterology report 6 40746370
2023 Abridged solid-phase extraction with alkaline Poly(ethylene) glycol lysis (ASAP) for direct DNA amplification. Talanta 6 37572478
2018 MAP9 single nucleotide polymorphism rs1058992 is a risk of EBV-associated gastric carcinoma in Chinese population. Acta virologica 6 30472874
2012 Amyloids as Sensors and Protectors (ASAP) hypothesis. Journal of Alzheimer's disease : JAD 6 22330832
2025 Comparison of the GALAD, GAAP, and ASAP Scores for Hepatocellular Carcinoma Detection in Patients With Chronic Liver Diseases. Journal of clinical and experimental hepatology 5 40689369
2025 Disease risk but not remission status determines transplant outcomes in AML: long-term outcomes of the ASAP trial. Blood 4 40737595
2024 ASAP: a platform for gene functional analysis in Angelica sinensis. BMC genomics 4 38262929
2022 ASAP 2: a pipeline and web server to analyze marker gene amplicon sequencing data automatically and consistently. BMC bioinformatics 4 34991446
2023 MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement. bioRxiv : the preprint server for biology 3 36865107
2022 MAP9 Exhibits Protumor Activities and Immune Escape toward Bladder Cancer by Mediating TGF-β1 Pathway. Journal of oncology 3 35656338
2025 Comparative Evaluation of ASAP and GALAD Scores for Detecting Hepatocellular Carcinoma in Patients With Chronic Liver Diseases. Journal of clinical gastroenterology 2 41071278
2024 Species Delimitation and Exploration of Species Partitions with ASAP and LIMES. Methods in molecular biology (Clifton, N.J.) 2 38683328
2024 CEUS LI-RADS in Combination With the Serum Biomarker-Based ASAP Model Improves the Diagnostic Performance of HCC in High-Risk Patients. Ultrasound in medicine & biology 2 39181805
2023 Massively Parallel Profiling of Accessible Chromatin and Proteins with ASAP-Seq. Methods in molecular biology (Clifton, N.J.) 2 36807072
2022 Functional Role of AsAP in the Reproduction of Adelphocoris suturalis (Hemiptera: Miridae). Insects 2 36005380
2020 Expression of MAP9 in Epstein-Barr virus-associated gastric carcinoma. Virus research 2 33309912
2024 ASAP: An automatic sequential assignment program for congested multidimensional solid state NMR spectra. Journal of magnetic resonance (San Diego, Calif. : 1997) 1 38522163
2026 ASAP-ML: Antibiotic Susceptibility and Antibiogram Prediction With Machine Learning Methods. IEEE transactions on computational biology and bioinformatics 0 41247898
2026 Diagnostic Performance Comparison of AFP, PIVKA-II, GALAD Model, and ASAP Model Across Two Chemiluminescence Immunoassay Platforms for Hepatocellular Carcinoma. Journal of hepatocellular carcinoma 0 41836603
2026 Comparison of diagnostic performance of GAAD, GALAD, and ASAP scores for detecting hepatocellular carcinoma in advanced liver fibrosis patients. Advances in laboratory medicine 0 41853788
2025 Preoperative ASAP score predicts recurrence and survival following curative hepatic resection for hepatitis B virus-related hepatocellular carcinoma: A multicenter cohort study. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 0 40769085
2025 ASAP-12 Score Predicts HBsAg Seroclearance and Seroconversion in Chronic Hepatitis B Patients Receiving Peg-IFNα Add-On Therapy. Journal of medical virology 0 41165473
2025 Absolute Membrane Potential Recording with ASAP-Type Genetically Encoded Voltage Indicators Using Fluorescence Lifetime Imaging. ACS chemical neuroscience 0 41273308
2024 New targets and designed inhibitors of ASAP Arf-GAPs derived from structural characterization of the ASAP1/440-kD ankyrin-B interaction. The Journal of biological chemistry 0 39265663
2000 ASAP: analysis of peptide composition. Bioinformatics (Oxford, England) 0 11159335