Affinage

KIF14

Kinesin-like protein KIF14 · UniProt Q15058

Length
1648 aa
Mass
186.5 kDa
Annotated
2026-06-10
48 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

KIF14 is a microtubule motor that drives the completion of cytokinesis by organizing the central spindle and midbody (PMID:16431929, PMID:16648480). It targets to the central spindle through interaction with PRC1 and recruits citron kinase (CIT-K/CRIK), with which it localizes codependently to the midbody to enable abscission; loss of KIF14 produces cytokinesis failure, endoreduplication, and multinucleated cells (PMID:16431929, PMID:16648480). The CIT-K/KIF14 interaction is gated by mitotic kinase phosphorylation of CIT-K, coupling midbody stability to cell-cycle signaling [PMID:bio_10.1101_2025.08.25.672096]. The motor itself is biochemically unusual: its motor domain binds microtubules tightly in a rigor-like state with robust ATPase activity but very slow motility, adopting an exceptionally twisted central β-sheet (PMID:24949858), while an intrinsically disordered N-terminal domain confers super-processivity, autonomous microtubule plus-end tip-tracking, parallel microtubule crosslinking, and antiparallel microtubule sliding (PMID:32649913). Beyond division, KIF14 functions in primary ciliogenesis and intraflagellar transport, where its depletion disrupts basal body and distal appendage protein localization and deregulates Aurora A activity (PMID:32348467). KIF14 also acts in cell adhesion and migration, tethering the Radil–Rap1 effector on microtubules to restrain inside-out integrin activation (PMID:23209302) and delivering adhesion cargoes such as vinculin to the leading edge to support focal adhesion assembly (PMID:40931756). Biallelic loss-of-function mutations in KIF14 cause a lethal fetal ciliopathy and primary microcephaly, with patient cells recapitulating the midbody-localization and cytokinesis defects (PMID:24128419, PMID:28892560). KIF14 expression is driven transcriptionally by Sp1, YY1, and E2F1 (PMID:24626475, PMID:40931756), and it is widely studied as a proliferation- and migration-promoting factor across cancers.

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 2006 High

    Established how KIF14 acts in cell division by placing it on the central spindle and linking it to the essential cytokinesis kinase citron kinase.

    Evidence Reciprocal endogenous Co-IP, RNAi depletion, and immunofluorescence in cultured cells, plus time-lapse imaging of cytokinesis phenotypes

    PMID:16431929 PMID:16648480

    Open questions at the time
    • Did not resolve the structural basis of midbody microtubule engagement
    • Mechanism by which CIT-K activation state gates complex formation left undefined
  2. 2012 High

    Extended KIF14 function beyond mitosis by showing it scaffolds the Radil-Rap1 axis on microtubules to control integrin activation and migration.

    Evidence Co-IP and pulldown for Radil PDZ binding plus RNAi with spreading, migration, and integrin activation assays

    PMID:23209302

    Open questions at the time
    • Whether motor activity vs. static tethering drives Radil sequestration not separated
    • Link to the mitotic role unestablished
  3. 2013 High

    Defined the in vivo physiological requirement for Kif14 in brain development via loss-of-function mouse and human genetics, connecting cytokinesis to neurodevelopmental disease.

    Evidence Positional cloning, knockout and transgenic rescue in mice; whole-exome sequencing and segregation in human ciliopathy families

    PMID:23308235 PMID:24128419

    Open questions at the time
    • Did not dissect which molecular activity (cytokinesis vs. cilia) drives the brain phenotype
    • Cellular mechanism not assayed in the human genetics report
  4. 2014 High

    Determined the motor's unusual mechanochemistry, revealing a rigor-like microtubule-binding state with strong ATPase but minimal motility.

    Evidence X-ray crystal structure of the ADP-bound motor domain, cryo-EM fitting, and in vitro ATPase, co-sedimentation, and motility assays (mouse motor domain)

    PMID:24949858

    Open questions at the time
    • Full-length motor behavior not addressed
    • Functional consequence of the tight-binding state in cells not tested here
  5. 2014 Medium

    Implicated KIF14 in cancer signaling networks, placing it upstream of SCF(Skp2)/p27 control of the cell cycle and as a promoter of AKT activation.

    Evidence RNAi, western blot, overexpression rescue for the Skp2/p27 axis; live-cell colocalization, knockdown, and small-molecule inhibition for AKT; ChIP and siRNA for Sp1/YY1 transcriptional control

    PMID:24626475 PMID:24784001 PMID:24854087

    Open questions at the time
    • Whether KIF14 directly or indirectly affects Skp2/p27 not resolved
    • Mechanism of KIF14-AKT functional coupling not defined biochemically here
  6. 2017 High

    Confirmed that KIF14 loss causes primary microcephaly through failed cytokinesis, validating the disease mechanism in patient cells and knockout mice.

    Evidence Whole-exome sequencing, immunofluorescence of patient fibroblasts showing impaired KIF14/CRIK midbody localization, RNAi, and Kif14 knockout mice

    PMID:28892560

    Open questions at the time
    • Did not test contribution of ciliary defects to microcephaly
    • Quantitative threshold of KIF14 function required for division not defined
  7. 2020 High

    Assigned distinct functional roles to KIF14's domains and discovered a ciliary function, showing the disordered N-terminus enables processivity/tip-tracking/sliding while depletion disrupts ciliogenesis via Aurora A.

    Evidence Single-molecule TIRF reconstitution with domain truncations; RNAi, imaging, Aurora A inhibition epistasis, and Hedgehog reporter assays

    PMID:32348467 PMID:32649913

    Open questions at the time
    • How the disordered domain's in vitro activities map onto specific in-cell ciliary/mitotic functions not directly linked
    • Aurora A-independent Hedgehog defect mechanism unresolved
  8. 2025 Medium

    Clarified ciliary mechanism and adhesion-cargo transport, showing KIF14 runs processively along the axoneme driving IFT and delivers vinculin to the leading edge under E2F1 transcriptional control.

    Evidence Live-cell/expansion/TIRF imaging with domain and patient-mutation analysis (preprint); Co-IP for vinculin, ChIP for E2F1, and metastasis models

    PMID:40931756 PMID:bio_10.1101_2025.03.20.644298

    Open questions at the time
    • Ciliary motility findings remain in preprint, not peer-reviewed
    • Whether cargo transport and IFT roles share a common motor mechanism not established
  9. 2026 Medium

    Extended post-translational regulation and signaling outputs, identifying BUB1 phosphorylation, MYCBP2 ubiquitination, and a KIF14-AKT axis modulating ferroptosis.

    Evidence Phospho-mutant rescue (Ser1292), GSEA with partial knockdown rescue for MYCBP2, and reciprocal Co-IP with AKT-activator rescue in cancer cells

    PMID:38498903 PMID:42036047 PMID:42083583

    Open questions at the time
    • MYCBP2-mediated ubiquitination not biochemically reconstituted
    • Direct vs. indirect KIF14-AKT coupling unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How KIF14's rigor-like, slow motor and its super-processive disordered-domain behavior are integrated into a single molecule to perform both midbody stabilization and processive ciliary/cargo transport remains unresolved.
  • No unified model linking motor mechanochemistry to its distinct cytokinetic, ciliary, and adhesion roles
  • Structure of full-length KIF14 in cargo-bound states not determined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0003774 cytoskeletal motor activity 3 GO:0008092 cytoskeletal protein binding 2 GO:0140657 ATP-dependent activity 1
Localization
GO:0005886 plasma membrane 3 GO:0005856 cytoskeleton 2 GO:0005929 cilium 2
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1640170 Cell Cycle 3 R-HSA-1474244 Extracellular matrix organization 2 R-HSA-1852241 Organelle biogenesis and maintenance 2
Partners
AKT1BUB1CITG3BP1MYCBP2PRC1RADILVCL
Complex memberships
KIF14-PRC1 complexKIF14-citron kinase complexcentral spindle/midbody

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 KIF14 interacts with PRC1 (protein-regulating cytokinesis 1) and targets to the central spindle via this interaction. KIF14 depletion causes citron kinase to fail to localize to the central spindle and midbody. KIF14 and citron kinase localization to the central spindle and midbody is codependent, and they form a complex depending on the activation state of citron kinase. Co-immunoprecipitation of endogenous proteins, RNAi depletion, immunofluorescence localization The Journal of cell biology High 16431929
2006 RNAi-mediated silencing of KIF14 induces cytokinesis failure, causing endoreduplication and multinucleated cells. KIF14 accumulates at spindle poles, spindle microtubules, and the midbody during mitosis. Partial KIF14 depletion (hypomorphic) causes multiple cell cycle phenotypes and acute apoptosis, while strong depletion causes cytokinesis failure. RNAi knockdown, time-lapse microscopy, immunofluorescence Molecular and cellular biology High 16648480
2012 KIF14 associates with the PDZ domain of Radil and negatively regulates Rap1-mediated inside-out integrin activation by tethering Radil on microtubules. Depletion of KIF14 leads to increased cell spreading, altered focal adhesion dynamics, and inhibition of cell migration and invasion. Co-immunoprecipitation, pulldown assay, RNAi knockdown with cell spreading/migration assays, integrin activation assay The Journal of cell biology High 23209302
2014 The mouse KIF14 motor domain binds tightly to microtubules and does not display typical nucleotide-dependent changes in microtubule affinity. It has robust ATPase activity but very slow motility. Crystal structure of the ADP-bound motor domain reveals a dramatically opened ATP-binding pocket with central β-sheet twisted ~10° beyond the maximal amount seen in other kinesins (rigor-like state). Cryo-EM fitting shows a distinct binding configuration to microtubules. Crystal structure (X-ray crystallography), cryo-electron microscopy, in vitro ATPase assay, microtubule co-sedimentation assay, motility assay Journal of molecular biology High 24949858
2014 KIF14 knockdown in hepatocellular carcinoma cells decreases Skp2 and Cks1 levels, leading to accumulation of p27(Kip1) protein by inhibiting its proteasome-dependent degradation. Overexpression of Skp2 in KIF14 knockdown cells attenuates cytokinesis failure, placing KIF14 upstream of the SCF(Skp2) complex in regulating p27(Kip1) ubiquitination. RNAi knockdown, western blot for SCF complex components, overexpression rescue, cell cycle analysis Experimental & molecular medicine Medium 24854087
2014 KIF14 ectopic expression promotes AKT phosphorylation and activity. Live-cell imaging confirmed an insulin-induced temporal colocalization of KIF14 and AKT at the plasma membrane. KIF14 knockdown correlates with decreased AKT phosphorylation. A small-molecule inhibitor of KIF14 reduces AKT activation. Live-cell imaging (colocalization), western blot (AKT phosphorylation), RNAi knockdown, overexpression, small-molecule inhibitor treatment Neoplasia (New York, N.Y.) Medium 24784001
2013 KIF14 loss-of-function mutations (autosomal recessive truncating mutations) cause a lethal fetal ciliopathy syndrome in humans with IUGR, microcephaly, renal cystic dysplasia, and brain malformations. Phenotype links KIF14 function in cell division/cytokinesis to primary cilia. Whole-exome sequencing, genetic segregation analysis in families Clinical genetics Medium 24128419
2017 Homozygous loss-of-function mutations in KIF14 cause primary microcephaly (MCPH) in humans. Patient-derived fibroblasts show impaired localization of both KIF14 and CRIK (citron kinase) at the midbody, and exhibit binucleated and apoptotic cells—hallmarks of failed cytokinesis. KIF14-depleted cells recapitulate these cytokinesis defects. Kif14 knockout mice also show primary microcephaly. Whole-exome sequencing, immunofluorescence of patient fibroblasts, RNAi depletion in cells, Kif14 knockout mouse model Annals of neurology High 28892560
2013 Kif14 splice-site mutation in mice (laggard) causes severe brain malformation, hypomyelination, and reduced expression of myelin-related genes. Kif14 knockout mice phenocopy laggard. Transgenic complementation with wild-type Kif14 cDNA rescues ataxic phenotype. Disrupted cytoarchitecture of cerebellar and cerebral cortices results from apoptotic cell death. Positional cloning, transgenic complementation, Kif14 knockout mouse generation, gene expression analysis, histology PloS one High 23308235
2020 The intrinsically disordered N-terminal domain of KIF14 enables unique functional diversity: (1) enables diffusibility of monomeric KIF14, (2) renders dimeric KIF14 super-processive and enables passage through crowded areas, (3) enables autonomous tracking of growing microtubule tips independent of EB proteins, and (4) is sufficient for crosslinking parallel microtubules and necessary for driving sliding of antiparallel microtubules. The disordered domain interacts diffusibly with the microtubule lattice and shows increased affinity for GTP-bound tubulin. Single-molecule TIRF microscopy in vitro, domain deletion/truncation analysis, microtubule tip-tracking assays, microtubule sliding assays Current biology : CB High 32649913
2020 KIF14 depletion leads to defects in primary ciliogenesis and basal body biogenesis, impairing efficiency of primary cilium formation and elongation dynamics, and disrupting localization of distal appendage proteins SCLT1 and FBF1 and IFT-B complex components. Deregulated Aurora A activity is identified as a mechanism contributing to cilia and basal body formation defects after KIF14 depletion. Primary cilia in KIF14-depleted cells are also defective in response to Hedgehog pathway activation, independently of Aurora A. RNAi depletion, immunofluorescence, live-cell imaging, epistasis with Aurora A inhibition, Hedgehog pathway reporter assay The Journal of cell biology High 32348467
2013 KIF14 overexpression inhibits anchorage-independent growth in vitro and xenograft tumor growth in vivo in lung adenocarcinoma, and modulates cancer cell migration, invasion, and adhesion to extracellular matrix. Cadherins CDH11 and MCAM were detected as cargo on KIF14; KIF14 overexpression enhances recruitment of CDH11 to the membrane fraction, suggesting KIF14 transports adhesion molecules to the cell membrane. Co-immunoprecipitation (cargo identification), cell fractionation (membrane fraction), overexpression and knockdown functional assays, xenograft mouse model PloS one Medium 23626713
2023 KIF14 binds the G3BP1/YBX1 complex and facilitates their interaction, causing increased NF-κB promoter activity and activation of the NF-κB pathway in cholangiocarcinoma cells. Co-immunoprecipitation, NF-κB promoter reporter assay, gain- and loss-of-function studies Oncogene Medium 36922675
2024 BUB1 phosphorylates KIF14 at serine 1292 (Ser1292). Overexpression of the KIF14-ΔSer1292 mutant (non-phosphorylatable) fails to facilitate aggressiveness of anaplastic thyroid cancer cells compared to wild-type KIF14, demonstrating that BUB1-mediated phosphorylation of KIF14 at Ser1292 is required for the BUB1/KIF14 complex to drive chromosome instability. Phosphorylation site identification, phospho-mutant overexpression, cell viability and invasion assays, xenograft model Journal of cellular and molecular medicine Medium 38498903
2021 LETM1 physically binds KIF14 (demonstrated by co-immunoprecipitation). Interference with LETM1 causes downregulation of KIF14 expression and leads to inhibition of proliferation, invasion, migration, and angiogenesis in esophageal squamous cell carcinoma cells. Co-immunoprecipitation, RNAi knockdown, proliferation/invasion/migration/tubule formation assays Bioengineered Low 34605738
2025 KIF14 binds directly to the focal adhesion protein vinculin and mediates its delivery to the leading edge of migrating colorectal cancer cells. KIF14 overexpression promotes focal adhesion assembly while KIF14 knockdown disrupts it. The transcription factor E2F1 directly binds the KIF14 promoter to drive its transcription, and E2F1 effects on metastasis are mediated through KIF14. Co-immunoprecipitation (KIF14-vinculin), chromatin immunoprecipitation (E2F1-KIF14 promoter), transcriptomic analysis, overexpression/knockdown functional assays, in vivo metastasis model Acta biochimica et biophysica Sinica Medium 40931756
2026 MYCBP2 (a ubiquitin E3 ligase) regulates KIF14 protein stability through ubiquitination. KIF14 expression is associated with better overall survival in AML, and KIF14 knockdown partially reverses the effects of MYCBP2 knockdown on cell viability and apoptosis, placing KIF14 downstream of MYCBP2-mediated ubiquitin-proteasome regulation. Gene Set Enrichment Analysis, siRNA knockdown, flow cytometry, co-immunoprecipitation (implied), in vivo xenograft model The Journal of biological chemistry Low 42036047
2025 Phosphorylation of citron kinase (CIT-K) at S699 by CDK1/Aurora B reduces its ability to interact with KIF14 at the midbody. This phosphorylation-dependent regulation of the CIT-K/KIF14 interaction controls midbody formation and stability. Phospho-mutant analysis, co-immunoprecipitation, immunofluorescence, cytokinesis functional assays bioRxivpreprint Medium bio_10.1101_2025.08.25.672096
2025 KIF14 localizes within primary cilia and drives processive runs along the ciliary axoneme. KIF14 depletion impairs intraflagellar transport (IFT). The motor domain drives processive ciliary motility in cooperation with the C-terminal CC1 domain. C-terminal truncations of KIF14 (including patient mutation Q1380x) cause traffic-jam-like accumulations of ciliary components in the distal cilia, leading to bulged cilia tips. Live-cell imaging, expansion microscopy, TIRF microscopy (in vitro and in cells), RNAi depletion, domain truncation analysis, patient mutation functional characterization bioRxivpreprint Medium bio_10.1101_2025.03.20.644298
2014 Transcriptional regulation of KIF14 overexpression in ovarian cancer involves Sp1 and YY1 transcription factors binding to the KIF14 promoter. ChIP confirmed enrichment of Sp1 and YY1 at the endogenous KIF14 promoter in high-KIF14-expressing ovarian cancer cell lines. siRNA knockdown of Sp1 and YY1 reduced endogenous KIF14 expression. miR-93, miR-144, and miR-382 post-transcriptionally regulate KIF14 mRNA levels. Promoter deletion analysis, ChIP, siRNA knockdown, miRNA mimic/inhibitor treatment PloS one Medium 24626475
2026 KIF14 depletion reduces AKT phosphorylation, decreases GPX4 and SLC7A11 expression, increases ACSL4, and sensitizes triple-negative breast cancer cells to ferroptosis. Reciprocal co-immunoprecipitation supports a physical association between endogenous KIF14 and AKT. AKT activator SC79 partially reverses the biochemical and ferroptosis phenotypes caused by KIF14 depletion. Reciprocal co-immunoprecipitation (KIF14-AKT), RNAi knockdown, western blot, ferroptosis assays (MDA, Fe2+, ferrostatin-1 rescue), AKT activator rescue Open life sciences Medium 42083583

Source papers

Stage 0 corpus · 48 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 KIF14 and citron kinase act together to promote efficient cytokinesis. The Journal of cell biology 232 16431929
2005 KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers. Oncogene 148 15897902
2006 RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure. Molecular and cellular biology 106 16648480
2006 KIF14 mRNA expression is a predictor of grade and outcome in breast cancer. International journal of cancer 95 16570270
2014 KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer. Neoplasia (New York, N.Y.) 84 24784001
2013 Exome sequencing identifies mutations in KIF14 as a novel cause of an autosomal recessive lethal fetal ciliopathy phenotype. Clinical genetics 81 24128419
2012 KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. The Journal of cell biology 67 23209302
2017 Mutations of KIF14 cause primary microcephaly by impairing cytokinesis. Annals of neurology 65 28892560
2019 Long non-coding RNA PAXIP1-AS1 facilitates cell invasion and angiogenesis of glioma by recruiting transcription factor ETS1 to upregulate KIF14 expression. Journal of experimental & clinical cancer research : CR 64 31823805
2013 A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 62 23479679
2018 Biallelic variants in KIF14 cause intellectual disability with microcephaly. European journal of human genetics : EJHG 59 29343805
2014 Silencing of KIF14 interferes with cell cycle progression and cytokinesis by blocking the p27(Kip1) ubiquitination pathway in hepatocellular carcinoma. Experimental & molecular medicine 50 24854087
2018 KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer. International journal of oncology 46 30226594
2013 Kif14 mutation causes severe brain malformation and hypomyelination. PloS one 41 23308235
2014 KIF14 binds tightly to microtubules and adopts a rigor-like conformation. Journal of molecular biology 40 24949858
2013 The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma. PloS one 39 23626713
2023 KIF14 promotes proliferation, lymphatic metastasis and chemoresistance through G3BP1/YBX1 mediated NF-κB pathway in cholangiocarcinoma. Oncogene 38 36922675
2015 Inhibition of KIF14 Suppresses Tumor Cell Growth and Promotes Apoptosis in Human Glioblastoma. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 35 26536004
2013 Suppression of KIF14 expression inhibits hepatocellular carcinoma progression and predicts favorable outcome. Cancer science 35 23414349
2007 High expression of KIF14 in retinoblastoma: association with older age at diagnosis. Investigative ophthalmology & visual science 35 17962437
2014 Transcriptional and epigenetic regulation of KIF14 overexpression in ovarian cancer. PloS one 31 24626475
2009 KIF14 and E2F3 mRNA expression in human retinoblastoma and its phenotype association. Molecular vision 27 19190782
2020 KIF14 controls ciliogenesis via regulation of Aurora A and is important for Hedgehog signaling. The Journal of cell biology 25 32348467
2017 The kinesin KIF14 is overexpressed in medulloblastoma and downregulation of KIF14 suppressed tumor proliferation and induced apoptosis. Laboratory investigation; a journal of technical methods and pathology 25 28504687
2014 Sox17 inhibits hepatocellular carcinoma progression by downregulation of KIF14 expression. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 22 25106407
2020 Silencing KIF14 reverses acquired resistance to sorafenib in hepatocellular carcinoma. Aging 21 33203790
2020 Intrinsically Disordered Domain of Kinesin-3 Kif14 Enables Unique Functional Diversity. Current biology : CB 20 32649913
2020 Histone Demethylase KDM3A Promotes Cervical Cancer Malignancy Through the ETS1/KIF14/Hedgehog Axis. OncoTargets and therapy 16 33239895
2022 KIF14 affects cell cycle arrest and cell viability in cervical cancer by regulating the p27Kip1 pathway. World journal of surgical oncology 15 35439960
2020 The Activity of KIF14, Mieap, and EZR in a New Type of the Invasive Component, Torpedo-Like Structures, Predetermines the Metastatic Potential of Breast Cancer. Cancers 15 32679794
2021 LETM1 (leucine zipper-EF-hand-containing transmembrane protein 1) silence reduces the proliferation, invasion, migration and angiogenesis in esophageal squamous cell carcinoma via KIF14 (kinesin family member 14). Bioengineered 14 34605738
2023 KIF14 mediates cabazitaxel-docetaxel cross-resistance in advanced prostate cancer by promoting AKT phosphorylation. Archives of biochemistry and biophysics 13 36822388
2022 MiR-17-3p Facilitates Aggressive Cell Phenotypes in Colon Cancer by Targeting PLCD1 Through Affecting KIF14. Applied biochemistry and biotechnology 13 36367621
2020 MiR-154-5p Suppresses Cell Invasion and Migration Through Inhibiting KIF14 in Nasopharyngeal Carcinoma. OncoTargets and therapy 12 32214824
2014 The role of KIF14 in patient-derived primary cultures of high-grade serous ovarian cancer cells. Journal of ovarian research 12 25528264
2024 BUB1/KIF14 complex promotes anaplastic thyroid carcinoma progression by inducing chromosome instability. Journal of cellular and molecular medicine 9 38498903
2020 miR-340 Exerts Suppressive Effect on Retinoblastoma Progression by Targeting KIF14. Current eye research 9 32757684
2018 Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14. Scientific reports 8 30385851
2024 RFC3 drives the proliferation, migration, invasion and angiogenesis of colorectal cancer cells by binding KIF14. Experimental and therapeutic medicine 7 38590579
2023 Novel circular RNA circ-0002727 regulates miR-144-3p/KIF14 pathway to promote lung adenocarcinoma progression. Frontiers in cell and developmental biology 7 38033864
2025 Identification of tRF-29-79MP9P9NH525 as a biomarker and tumor suppressor of gastric cancer via regulating KIF14/AKT pathway. Cell death discovery 3 40374610
2023 Replication Timing Aberration of KIF14 and MDM4 / 2 β Alleles and Aneuploidy as Markers of Chromosomal Instability and Poor Treatment Response in Ewing Family Tumor Patients. Global medical genetics 2 37091312
2026 KIF14 in cancer biology: implications for diagnosis and therapy. Clinical & experimental metastasis 1 41511650
2025 RCN1 Binds KIF14 and Promotes the Malignant Growth of Cervical Cancer Through the PI3K-AKT Pathway. International journal of general medicine 1 40927771
2025 The E2F1‒KIF14 axis drives focal adhesion formation and promotes colorectal cancer metastasis. Acta biochimica et biophysica Sinica 1 40931756
2026 Ubiquitin E3 ligase MYCBP2 targets KIF14 and contributes to acute myeloid leukemia progression. The Journal of biological chemistry 0 42036047
2026 KIF14-AKT axis regulates ferroptosis sensitivity in triple-negative breast cancer. Open life sciences 0 42083583
2025 KIF14 as a Dual Microtubule/F-Actin Binding Protein Contributing to Cytokinesis. Cytoskeleton (Hoboken, N.J.) 0 40717607

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