Affinage

CIT

Citron Rho-interacting kinase · UniProt O14578

Length
2027 aa
Mass
231.4 kDa
Annotated
2026-06-09
100 papers in source corpus 11 papers cited in narrative 10 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CIT (citron rho-interacting serine/threonine kinase, CITK/CRIK) is a kinase that governs the fidelity of neural progenitor cell (NPC) division, with both its catalytic activity and scaffolding function required for cytokinesis polarity and proper human corticogenesis (PMID:39316437). During mitosis CITK controls spindle orientation by regulating astral microtubule nucleation and stability, and is recruited to the spindle pole by ASPM; its overexpression rescues the spindle-orientation defect caused by ASPM loss (PMID:27562601). CITK also localizes to the midbody ring during cytokinesis, where its loss produces defective neurogenic cytokinesis (PMID:27519304, PMID:27503289). Biallelic loss-of-function splice-site variants in CIT that disrupt the kinase domain cause autosomal-recessive primary microcephaly (MCPH17) in humans (PMID:27519304, PMID:27503289), and human kinase-dead forebrain organoids phenocopy the loss-of-function organoid defects (loss of pseudostratified cytoarchitecture, impaired NPC cytokinesis polarity, elevated apoptosis), establishing that catalytic activity is essential in the human context even though it is dispensable in mouse (PMID:39316437). Beyond neurogenesis, CITK acts in a Rho/CRIK/KyoT1-2 (FHL1) axis to suppress keratinocyte differentiation (PMID:16061799), and its elevated expression promotes proliferation and survival across colon, bladder, breast, and medulloblastoma cells through p53 and cell-cycle pathways (PMID:29069760, PMID:31972359, PMID:30565087); in medulloblastoma, CITK loss additionally causes cytokinesis failure, DNA-damage accumulation, and reduced nuclear RAD51, impairing homologous-recombination repair (PMID:32111106).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 2005 Medium

    Established a signaling role for CITK outside mitosis by showing it transduces Rho signaling to block epithelial differentiation, defining a downstream effector axis.

    Evidence Overexpression/knockdown of CRIK in keratinocyte lines with expression profiling and epistasis with activated Rho

    PMID:16061799

    Open questions at the time
    • Mechanism by which CITK induces KyoT1/2 (FHL1) not defined
    • Whether catalytic activity is required for the differentiation block untested
    • Single-lab finding without in vivo skin model
  2. 2010 Low

    Raised the question of whether CIT contributes to neuropsychiatric risk by reporting statistical epistasis between CIT and DISC1/NDEL1 variants in schizophrenia.

    Evidence Machine-learning epistasis analysis in a case-control cohort with fMRI intermediate-phenotype validation

    PMID:20084519

    Open questions at the time
    • No direct biochemical experiment on CIT protein
    • Genetic association does not establish causal mechanism
    • DISC1-interaction domain function not biochemically tested
  3. 2016 High

    Defined a mitotic mechanism for CITK: how dividing cells orient their spindle, showing CITK is recruited to the spindle pole by ASPM to regulate astral microtubule dynamics.

    Evidence siRNA knockdown in mouse cortical progenitors and Drosophila, spindle-orientation assays, live imaging, drug rescue, and epistasis with ASPM

    PMID:27562601

    Open questions at the time
    • Direct substrate at the spindle pole not identified
    • Molecular basis of ASPM-mediated recruitment unresolved
    • Whether kinase activity vs scaffolding drives astral-MT regulation not separated here
  4. 2016 High

    Connected CITK loss to human disease, demonstrating that kinase-domain-disrupting biallelic variants cause primary microcephaly via defective neurogenic cytokinesis.

    Evidence Homozygosity mapping, whole-exome sequencing, and cDNA validation of aberrant splicing in affected individuals

    PMID:27503289 PMID:27519304

    Open questions at the time
    • Genetic data alone do not isolate catalytic from scaffolding contributions
    • Cell-type specificity of the requirement not resolved
  5. 2017 Medium

    Extended CITK function to tumor biology, showing its elevated activity supports colon cancer growth through the p53 pathway.

    Evidence siRNA knockdown in colon cancer lines with proliferation, colony-formation, xenograft assays, and microarray pathway placement

    PMID:29069760

    Open questions at the time
    • Direct molecular link between CITK and p53 not defined
    • Whether the effect requires kinase activity untested
  6. 2018 Medium

    Generalized the pro-proliferative role of CITK to breast cancer, implicating cell-cycle and growth-signaling effectors.

    Evidence Lentiviral shRNA knockdown across breast cancer lines with proliferation/invasion assays, xenograft, and microarray

    PMID:30565087

    Open questions at the time
    • Effectors (cyclin D1, EGFR, JAK1, mTOR) shown as correlative expression changes, not mechanistic targets
    • No reciprocal gain-of-function validation
  7. 2020 Medium

    Reinforced CITK's oncogenic role in bladder cancer and placed it post-transcriptionally downstream of a circRNA/miRNA axis acting on p53 and RhoA-ROCK signaling.

    Evidence Knockdown in bladder cancer lines with cell-cycle/apoptosis assays, xenograft, and luciferase reporters for circRNA_0071196/miR-19b-3p/CIT

    PMID:31972359 PMID:32705161

    Open questions at the time
    • Direct mechanistic link from CITK to p53/RhoA-ROCK changes not established
    • Single-lab functional assays
  8. 2020 Medium

    Revealed a DNA-repair dimension of CITK function in medulloblastoma, linking its loss to homologous-recombination impairment and radio/chemosensitization.

    Evidence siRNA knockdown in Group 3/4 medulloblastoma lines, γH2AX and RAD51 immunofluorescence, clonogenic survival with IR/cisplatin

    PMID:32111106

    Open questions at the time
    • Mechanism connecting CITK to RAD51 nuclear loading unknown
    • Whether HR defect is secondary to cytokinesis failure not resolved
  9. 2024 High

    Resolved the long-standing question of whether CITK catalytic activity matters for human brain development, showing both kinase and scaffolding functions are required in human NPCs while the mouse tolerates kinase-dead alleles.

    Evidence CRISPR knock-in mouse models and human forebrain organoids (kinase-dead and loss-of-function), 3D live imaging of NPC mitosis, cytoarchitecture and apoptosis analysis

    PMID:39316437

    Open questions at the time
    • Molecular basis of human-specific catalytic requirement unexplained
    • Catalytic substrates governing cytokinesis polarity not identified

Open questions

Synthesis pass · forward-looking unresolved questions
  • The direct phosphorylation substrates of CITK that mediate spindle orientation, cytokinesis polarity, and the p53/HR phenotypes remain unidentified.
  • No catalytic substrate mapped to any phenotype
  • Molecular link between CITK and p53/RAD51 pathways undefined
  • Structural basis of ASPM recruitment unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 2 GO:0008092 cytoskeletal protein binding 1
Localization
GO:0005815 microtubule organizing center 1 GO:0005856 cytoskeleton 1
Pathway
R-HSA-1640170 Cell Cycle 4 R-HSA-1266738 Developmental Biology 1
Partners
ASPM

Evidence

Reading pass · 10 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 CITK (citron kinase) controls spindle orientation by regulating astral microtubule dynamics; loss of CITK in mammals and insects leads to abnormal spindle orientation, and ASPM is required to recruit CITK to the spindle pole. CITK overexpression rescues the ASPM loss-of-function spindle orientation phenotype. CITK regulates both astral-MT nucleation and stability. siRNA knockdown in mouse cortical progenitors and Drosophila, spindle orientation assays, live imaging, low-dose MT-stabilizing drug rescue experiments, co-localization and epistasis analyses EMBO reports High 27562601
2016 Biallelic loss-of-function splice-site variants in CIT (citron kinase) cause severe autosomal recessive primary microcephaly (MCPH17) in humans. The splice-site variant causes intron retention, predicting disruption of the kinase domain. CIT co-localizes to the midbody ring during cytokinesis; its loss results in defective neurogenic cytokinesis. Genome-wide homozygosity mapping, whole-exome sequencing, cDNA sequencing of affected individuals to confirm aberrant splicing Human genetics High 27503289 27519304
2005 Rho/CRIK (citron kinase) signaling suppresses keratinocyte differentiation; CRIK is selectively down-modulated during differentiation, and its over-activity (via Rho) maintains cells in an undifferentiated state. This suppressing function is coupled with induction of KyoT1/2 (FHL1), a LIM-domain protein that itself suppresses differentiation. Overexpression and knockdown of CRIK in keratinocyte cell lines, gene expression profiling, epistasis with activated Rho Proceedings of the National Academy of Sciences of the United States of America Medium 16061799
2017 CIT (citron kinase) promotes colon cancer cell growth by regulating the p53 signaling pathway; CIT knockdown induces cell cycle arrest and apoptosis, reduces colony formation in vitro, and reduces tumor growth in xenograft experiments. siRNA knockdown in colon cancer cell lines, proliferation and colony-formation assays, in vivo xenograft, microarray/bioinformatics analysis implicating p53 pathway Oncotarget Medium 29069760
2020 CIT (citron kinase) promotes bladder cancer cell proliferation and colony formation; knockdown induces cell-cycle arrest and apoptosis in vitro and reduces tumor volume in vivo. Microarray analysis indicates CIT acts through the cell cycle signaling pathway. CIT knockdown also upregulates p53 and RhoA-ROCK signaling mediators. siRNA/shRNA knockdown in bladder cancer cell lines (5367, T24), cell-cycle analysis, apoptosis assays, xenograft model, microarray expression profiling Biomedicine & pharmacotherapy Medium 31972359
2020 CIT is regulated post-transcriptionally in bladder cancer by a circRNA_0071196/miRNA-19b-3p/CIT axis; circRNA_0071196 sponges miRNA-19b-3p to upregulate CIT levels. CIT knockdown inhibits proliferation, migration, and colony formation and upregulates p53 and RhoA-ROCK pathway mediators. Luciferase reporter assay (validating circRNA_0071196–miR-19b-3p and miR-19b-3p–CIT interactions), CIT knockdown in 5637 cells, functional assays (proliferation, migration, colony formation) International journal of oncology Medium 32705161
2018 Citron kinase (CIT-K) promotes breast cancer cell proliferation, migration, invasion and tumorigenicity in vivo; knockdown reduces colony formation, induces apoptosis and cell-cycle arrest. Microarray analysis shows altered expression of cyclin D1, EGFR, JAK1, TGF-α, mTOR, and other signaling genes after CIT-K silencing. Lentiviral shRNA knockdown in multiple breast cancer cell lines, Western blot, proliferation/colony/transwell assays, flow cytometry, nude mouse xenograft, microarray Clinical & translational oncology Medium 30565087
2020 CITK (citron kinase) loss impairs proliferation and induces cytokinesis failure and apoptosis in Group 3/4 medulloblastoma cells. CITK knockdown also causes accumulation of DNA damage and reduced RAD51 nuclear levels, indicating impairment of homologous recombination. Combined CITK knockdown with ionizing radiation or cisplatin strongly reduces growth of all tested medulloblastoma cell lines. siRNA knockdown in D283, D341, ONS-76, DAOY cells; proliferation assays; DNA damage markers (γH2AX); RAD51 nuclear localization by immunofluorescence; clonogenic survival with IR/cisplatin Cancers Medium 32111106
2024 Both the catalytic (kinase) activity and the scaffolding function of CIT are required for NPC cytokinesis polarity and human corticogenesis. CITKI/KI (kinase-dead) human forebrain organoids lose cytoarchitectural complexity (pseudostratified to simple neuroepithelium) and show defects in NPC cytokinesis polarity and elevated apoptosis, similar to CITFS/FS (loss-of-function) organoids. By contrast, the CitKI/KI mouse model does not phenocopy human microcephaly, whereas CitFS/FS mice do; both exhibit binucleation, DNA damage, and apoptosis. CRISPR knock-in mouse models (CitKI/KI, CitFS/FS), human forebrain organoids (CITKI/KI and CITFS/FS), live 3D imaging of NPC mitosis, apoptosis assays, cytoarchitecture analysis The Journal of clinical investigation High 39316437
2010 Statistical epistasis between CIT SNPs (rs3847960, rs440299, rs10744743) and DISC1/NDEL1 SNPs is associated with schizophrenia risk. The interacting CIT SNPs are proximal to exons encoding the DISC1-interaction domain of CIT, suggesting a functional basis for the genetic interaction. Machine-learning algorithms (random forest, gradient boosting, Monte Carlo logic regression) plus logistic regression for epistasis in case-control cohort; functional validation by fMRI (prefrontal cortical efficiency on N-back task) in independent healthy-control sample Human genetics Low 20084519

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1994 Graphical, kinetic, and equilibrium analyses of in vivo [123I] beta-CIT binding to dopamine transporters in healthy human subjects. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 266 7929662
2007 Dementia with Lewy bodies: a comparison of clinical diagnosis, FP-CIT single photon emission computed tomography imaging and autopsy. Journal of neurology, neurosurgery, and psychiatry 218 17353255
2001 The clinical benefit of imaging striatal dopamine transporters with [123I]FP-CIT SPET in differentiating patients with presynaptic parkinsonism from those with other forms of parkinsonism. European journal of nuclear medicine 201 11315592
2001 Sex differences in [123I]beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers. Synapse (New York, N.Y.) 201 11494398
2004 Combined 123I-FP-CIT and 123I-IBZM SPECT for the diagnosis of parkinsonian syndromes: study on 72 patients. Journal of neural transmission (Vienna, Austria : 1996) 154 15375677
2014 Development of a multiplex real-time PCR for the rapid detection of the predominant beta-lactamase genes CTX-M, SHV, TEM and CIT-type AmpCs in Enterobacteriaceae. PloS one 144 25033234
1997 Imaging of dopamine transporters with iodine-123-beta-CIT and SPECT in Parkinson's disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 137 8998140
1998 Imaging the pre- and postsynaptic side of striatal dopaminergic synapses in idiopathic cervical dystonia: a SPECT study using [123I] epidepride and [123I] beta-CIT. Movement disorders : official journal of the Movement Disorder Society 119 9539347
2000 Impaired dopaminergic neurotransmission in patients with traumatic brain injury: a SPECT study using 123I-beta-CIT and 123I-IBZM. European journal of nuclear medicine 118 11007526
1998 Drug-naive patients with Parkinson's disease in Hoehn and Yahr stages I and II show a bilateral decrease in striatal dopamine transporters as revealed by [123I]beta-CIT SPECT. Journal of neurology 113 9457623
2000 Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [(123)I]beta-CIT. Biological psychiatry 109 10704949
2006 [123I]-FP/CIT SPECT imaging for distinguishing drug-induced parkinsonism from Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 108 16250023
2004 Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype. The American journal of psychiatry 103 14992979
2005 Voxel-wise analysis of [123I]beta-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease. Brain : a journal of neurology 90 15817519
1998 Dopamine transporter density measured by [123I]beta-CIT single-photon emission computed tomography is normal in dopa-responsive dystonia. Annals of neurology 87 9629849
1993 Evaluation of the monoamine uptake site ligand [123I]methyl 3 beta-(4-iodophenyl)-tropane-2 beta-carboxylate ([123I]beta-CIT) in non-human primates: pharmacokinetics, biodistribution and SPECT brain imaging coregistered with MRI. Nuclear medicine and biology 87 8358345
1997 Measurement of the dopaminergic degeneration in Parkinson's disease with [123I] beta-CIT and SPECT. Correlation with clinical findings and comparison with multiple system atrophy and progressive supranuclear palsy. Journal of neural transmission. Supplementum 84 9120429
2003 [(123)I]beta-CIT SPECT is a useful method for monitoring dopaminergic degeneration in early stage Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry 83 12588911
2010 Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging. Human genetics 81 20084519
1998 Tourette's syndrome: [I-123]beta-CIT SPECT correlates of vocal tic severity. Neurology 69 9781531
2014 [¹²³I]FP-CIT SPECT (DaTSCAN) may be a useful tool to differentiate between Parkinson's disease and vascular or drug-induced parkinsonisms: a meta-analysis. European journal of neurology 67 24779862
2011 Diagnostic accuracy of combined FP-CIT, IBZM, and MIBG scintigraphy in the differential diagnosis of degenerative parkinsonism: a multidimensional statistical approach. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 63 21498527
2016 ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules. EMBO reports 58 27562601
2001 Imaging of dopamine transporters with [123I]FP-CIT SPECT does not suggest a significant effect of age on the symptomatic threshold of disease in Parkinson's disease. Synapse (New York, N.Y.) 55 11180497
2007 Validation of a standardized normalization template for statistical parametric mapping analysis of 123I-FP-CIT images. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 54 17704252
2007 [123I]FP-CIT striatal binding in early Parkinson's disease patients with tremor vs. akinetic-rigid onset. Neuroreport 53 17712282
1996 Demonstration of the existence of mRNAs encoding N1/cif and N2/cit sodium/nucleoside cotransporters in rat brain. Brain research. Molecular brain research 48 9013795
2016 CIT, a gene involved in neurogenic cytokinesis, is mutated in human primary microcephaly. Human genetics 47 27519304
1998 123I-beta-CIT and 123I-IBZM-SPECT scanning in levodopa-naive Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 47 9613734
2005 Isolation, cloning and allergenic reactivity of natural profilin Cit s 2, a major orange allergen. Allergy 46 16197476
2004 Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease. Neurology 46 15596756
2008 [123I]FP-CIT SPET imaging in drug-induced Parkinsonism. Movement disorders : official journal of the Movement Disorder Society 43 18759353
2008 [123I]-FP-CIT and [99mTc]-HMPAO single photon emission computed tomography in a new sporadic case of rapid-onset dystonia-parkinsonism. Journal of the neurological sciences 41 18675996
2002 Evaluation of striatal dopamine transporter function in rats by in vivo beta-[123I]CIT pinhole SPECT. NeuroImage 41 12482072
2008 Cost-effectiveness of 123I-FP-CIT SPECT in the differential diagnosis of essential tremor and Parkinson's disease in Italy. Movement disorders : official journal of the Movement Disorder Society 40 18785639
2006 Germin-like protein Cit s 1 and profilin Cit s 2 are major allergens in orange (Citrus sinensis) fruits. Molecular nutrition & food research 39 16521162
2016 Implementation of the European multicentre database of healthy controls for [(123)I]FP-CIT SPECT increases diagnostic accuracy in patients with clinically uncertain parkinsonian syndromes. European journal of nuclear medicine and molecular imaging 38 26780619
2003 Investigating dopaminergic neurotransmission with 123I-FP-CIT SPECT: comparability of modern SPECT systems. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 36 12732687
2005 Decreased striatal dopamine transporter binding assessed with [123I] FP-CIT in first-episode schizophrenic patients with and without short-term antipsychotic-induced parkinsonism. Psychopharmacology 34 15830229
2004 123I-beta-CIT SPECT demonstrates increased presynaptic dopamine transporter binding sites in basal ganglia in vivo in schizophrenia. Psychopharmacology 34 14712338
2023 GPR109A controls neutrophil extracellular traps formation and improve early sepsis by regulating ROS/PAD4/Cit-H3 signal axis. Experimental hematology & oncology 33 36721229
2007 Quantitative [(123)I]FP-CIT pinhole SPECT imaging predicts striatal dopamine levels, but not number of nigral neurons in different mouse models of Parkinson's disease. NeuroImage 33 17716921
2016 Mutations in CIT, encoding citron rho-interacting serine/threonine kinase, cause severe primary microcephaly in humans. Human genetics 31 27503289
2010 Citrinin (CIT) determination in rice samples using a micro fluidic electrochemical immunosensor. Talanta 31 21147345
2006 Diagnostic value of asymmetric striatal D2 receptor upregulation in Parkinson's disease: an [123I]IBZM and [123I]FP-CIT SPECT study. European journal of nuclear medicine and molecular imaging 31 17053905
2015 Altered serotonin and dopamine transporter availabilities in brain of depressed patients upon treatment with escitalopram: A [123 I]β-CIT SPECT study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 27 25819144
2005 Negative control of keratinocyte differentiation by Rho/CRIK signaling coupled with up-regulation of KyoT1/2 (FHL1) expression. Proceedings of the National Academy of Sciences of the United States of America 27 16061799
1998 Assessment of affinities of beta-CIT, beta-CIT-FE, and beta-CIT-FP for monoamine transporters permanently expressed in cell lines. Nuclear medicine and biology 26 9466362
2013 High correlation between in vivo [123I]β-CIT SPECT/CT imaging and post-mortem immunohistochemical findings in the evaluation of lesions induced by 6-OHDA in rats. EJNMMI research 25 23758882
2012 [¹²³I]FP-CIT single photon emission computed tomography findings in drug-induced Parkinsonism. Schizophrenia research 25 22727453
2016 123I-FP-CIT SPECT findings and its clinical relevance in prodromal dementia with Lewy bodies. European journal of nuclear medicine and molecular imaging 24 27480759
2005 Orange germin-like glycoprotein Cit s 1: an equivocal allergen. International archives of allergy and immunology 24 16357490
2023 Anti-citrullinated histone monoclonal antibody CIT-013, a dual action therapeutic for neutrophil extracellular trap-associated autoimmune diseases. mAbs 23 38031350
2020 Novel circRNA_0071196/miRNA‑19b‑3p/CIT axis is associated with proliferation and migration of bladder cancer. International journal of oncology 22 32705161
2014 Improved dopamine transporter binding activity after bone marrow mesenchymal stem cell transplantation in a rat model of Parkinson's disease: small animal positron emission tomography study with F-18 FP-CIT. European radiology 21 25504429
2011 CcpA represses the expression of the divergent cit operons of Enterococcus faecalis through multiple cre sites. BMC microbiology 21 21989394
2001 Rigidity decreases resting tremor intensity in Parkinson's disease: A [(123)I]beta-CIT SPECT study in early, nonmedicated patients. Movement disorders : official journal of the Movement Disorder Society 21 11748734
2017 Up-regulation of CIT promotes the growth of colon cancer cells. Oncotarget 20 29069760
2013 ¹²³I-FP-Cit and 123I-IBZM SPECT uptake in a prospective normal material analysed with two different semiquantitative image evaluation tools. Nuclear medicine communications 20 23903558
2020 BDNF levels and nigrostriatal degeneration in "drug naïve" Parkinson's disease patients. An "in vivo" study using I-123-FP-CIT SPECT. Parkinsonism & related disorders 18 32682292
2016 Cit/CuS@Fe3O4-based and enzyme-responsive magnetic nanoparticles for tumor chemotherapy, photothermal, and photodynamic therapy. Journal of biomaterials applications 18 28178904
2010 Efficacy of romiplostim in the treatment of chemotherapy induced thrombocytopenia (CIT) in a patient with mantle cell lymphoma. Pathology oncology research : POR 18 20628840
2007 Parkinsonism and essential tremor in a family with pseudo-dominant inheritance of PARK2: an FP-CIT SPECT study. Movement disorders : official journal of the Movement Disorder Society 18 17149727
1997 A novel bend of DNA CIT: changeable bending-center sites of an intrinsic curvature under temperature conditions. FEMS microbiology letters 18 9037772
2021 123I-FP-CIT SPECT in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease: a new quantitative analysis of autopsy confirmed cases. Journal of neurology, neurosurgery, and psychiatry 17 33542085
2020 CITK Loss Inhibits Growth of Group 3 and Group 4 Medulloblastoma Cells and Sensitizes Them to DNA-Damaging Agents. Cancers 17 32111106
2006 Molecular and immunological characterization of the glycosylated orange allergen Cit s 1. Glycobiology 17 17095532
2004 Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT). Bioorganic & medicinal chemistry letters 17 15080991
2016 FP-CIT- and IBZM-SPECT in Corticobasal Syndrome: Results from a Clinical Follow-Up Study. Neuro-degenerative diseases 16 26978429
2022 Dual-phase 18 F-FP-CIT positron emission tomography and cardiac 123 I-MIBG scintigraphy of Parkinson's disease patients with GBA mutations: evidence of the body-first type? European journal of neurology 15 36288409
2014 Automated quantification with BRASS reduces equivocal reporting of DaTSCAN (123I-FP-CIT) SPECT studies. Nuclear medicine review. Central & Eastern Europe 15 25088104
2014 The antiosteoporotic activity of central-icaritin (CIT) on bone metabolism of ovariectomized rats. Molecules (Basel, Switzerland) 14 25405287
2010 Proteome from lemon fruit flavedo reveals that this tissue produces high amounts of the Cit s1 germin-like isoforms. Journal of agricultural and food chemistry 14 20499937
2006 [Study of presynaptic nigrostriatal pathway by 123-I-FD-CIT-SPECT (DatSCAN SPECT) in primary orthostatic tremor]. Neurologia (Barcelona, Spain) 14 16525925
2019 Individual parkinsonian motor signs and striatal dopamine transporter deficiency: a study with [I-123]FP-CIT SPECT. Journal of neurology 13 30687897
2010 C-It: a knowledge database for tissue-enriched genes. Bioinformatics (Oxford, England) 13 20628071
2001 Addition of a 5-HT receptor agonist to methylphenidate potentiates the reduction of [123I]FP-CIT binding to dopamine transporters in rat frontal cortex and hippocampus. Synapse (New York, N.Y.) 13 11169768
2024 Tumor beta2-microglobulin and HLA-A expression is increased by immunotherapy and can predict response to CIT in association with other biomarkers. Frontiers in immunology 12 38455061
2020 Down-regulation of CIT can inhibit the growth of human bladder cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 12 31972359
2018 Citron kinase (CIT-K) promotes aggressiveness and tumorigenesis of breast cancer cells in vitro and in vivo: preliminary study of the underlying mechanism. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 12 30565087
2015 CIT-7, a crystalline, molecular sieve with pores bounded by 8 and 10-membered rings. Chemical science 12 29163872
1997 [Striatal uptake of I-123-beta-CIT and I-123-IBZM in patients with extrapyramidal symptoms]. Nuklearmedizin. Nuclear medicine 12 9380528
2013 Effect of long-term treatment with pramipexole or levodopa on presynaptic markers assessed by longitudinal [123I]FP-CIT SPECT and histochemistry. NeuroImage 11 23631981
2024 Modeling primary microcephaly with human brain organoids reveals fundamental roles of CIT kinase activity. The Journal of clinical investigation 10 39316437
2022 Effect of avatrombopag in the management of severe and refractory chemotherapy-induced thrombocytopenia (CIT) in patients with solid tumors. Platelets 10 35040375
2007 [Diagnostic accuracy of FP-CIT SPECT in patients with parkinsonism]. Revista espanola de medicina nuclear 10 17910836
1994 Characterization of the cit-1 gene from Neurospora crassa encoding the mitochondrial form of citrate synthase. Molecular & general genetics : MGG 10 7904043
2016 Intranasal Dopamine Reduces In Vivo [(123)I]FP-CIT Binding to Striatal Dopamine Transporter: Correlation with Behavioral Changes and Evidence for Pavlovian Conditioned Dopamine Response. Frontiers in behavioral neuroscience 9 27148001
2022 18F-FP-CIT PET/CT in a case of probable sporadic Creutzfeldt-Jakob disease with parkinsonism as initial symptom. Prion 8 35801711
2020 An innovative genosensor for the monitoring of Leishmania spp sequence using binding of pDNA to cDNA based on Cit-AgNPs. Heliyon 8 32904219
2018 Antidepressant treatment effects on dopamine transporter availability in patients with major depression: a prospective 123I-FP-CIT SPECT imaging genetic study. Journal of neural transmission (Vienna, Austria : 1996) 8 29476250
2018 123I-FP-CIT SPECT [(123) I-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T α-synuclein Parkinson's disease cohort versus Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society 8 30288781
2017 Correlations between dopamine transporter density measured by 123I-FP-CIT SPECT and regional gray matter volume in Parkinson's disease. Japanese journal of radiology 8 29063467
2016 Test-retest reproducibility of extrastriatal binding with 123I-FP-CIT SPECT in healthy male subjects. Psychiatry research. Neuroimaging 8 27814458
1998 Enhancement of in vivo binding of [123I]beta-CIT by MK-801 in rat brain. Synapse (New York, N.Y.) 8 9826232
1996 Visualization of ischemic insult in caudate putamen with beta-CIT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 8 8965201
2024 I123-FP-CIT (DaTSCAN) SPECT beyond the Most Common Causes of Parkinsonism: A Systematic Review. Movement disorders clinical practice 7 38693679
2015 Characterization of [123I]FP-CIT binding to the dopamine transporter in the striatum of tree shrews by quantitative in vitro autoradiography. Synapse (New York, N.Y.) 7 26126942
2012 Cerebrotendinous xanthomatosis presenting with asymmetric parkinsonism: a case with I-123-FP-CIT SPECT imaging. Acta neurologica Belgica 7 22527785
2012 Visualizing dopamine transporter integrity with iodine-123-FP-CIT SPECT in combination with high resolution MRI in the brain of the common marmoset monkey. Journal of neuroscience methods 7 22827895

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