Affinage

IQGAP2

Ras GTPase-activating-like protein IQGAP2 · UniProt Q13576

Length
1575 aa
Mass
180.6 kDa
Annotated
2026-06-10
41 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

IQGAP2 is a multidomain cytoplasmic scaffold protein that integrates Rho-family GTPase signaling, cytoskeletal organization, and cell adhesion to constrain proliferative and inflammatory programs (PMID:8756646, PMID:18180285). It binds Cdc42 and Rac1, but not RhoA or Ras, through its C-terminal GAP-related domain in a nucleotide-independent manner, and rather than catalyzing GTP hydrolysis it inhibits both intrinsic and GAP-stimulated hydrolysis, effectively stabilizing the GTP-bound state of these GTPases (PMID:8756646, PMID:8702968); structurally, two Cdc42 molecules can engage IQGAP2 cooperatively—one at an extra GRD site requiring the Cdc42 insert loop and one at the RasGAP site—an arrangement that drives IQGAP2 dimerization, whereas Rac1 occupies only the RasGAP site (PMID:29358323). Through an N-terminal calponin-homology domain it binds F-actin, and via its IQ motifs it binds calmodulin in a calcium- and motif-selective fashion (PMID:8756646, PMID:21299499). These activities support cytoskeletal remodeling and adhesion: in thrombin-activated platelets IQGAP2 assembles a Rac1-GTP-dependent complex with Arp2/3 and actin and translocates to the cytoskeleton (PMID:12515716), and it is required for cadherin-mediated cell-cell adhesion, maintaining E-cadherin, beta-catenin, and actin at cell borders (PMID:17617398, PMID:18180285). In hepatocytes IQGAP2 forms a scaffolding complex with IQGAP1, beta-catenin, and E-cadherin, and its loss causes IQGAP1 overexpression, beta-catenin activation, and cyclin D1 induction, with the resulting hepatocellular carcinoma phenotype genetically dependent on IQGAP1 (PMID:18180285); IQGAP2 directly binds and sequesters IQGAP1 to suppress ERK activation, acting broadly as a tumor suppressor that also restrains AKT/mTOR-driven proliferation and EMT (PMID:33846302, PMID:37154877). It limits oncogenic AKT signaling by binding SHIP2 and elevating its phosphatase activity (PMID:32183047), and supports antiviral and metabolic programs by interacting with RelA/NF-kB to induce a subset of interferon-stimulated genes (PMID:27401546) and with GSK3 and glycogen synthase to sustain fed-state hepatic glycogen synthesis downstream of insulin (PMID:37805137). IQGAP2 additionally functions in epithelial transport and barrier homeostasis, stabilizing solute transporters at the apical colonocyte membrane (PMID:39401425) and maintaining blood-brain barrier immune privilege by suppressing endothelial adhesion-receptor and antigen-processing expression (PMID:40071147).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1996 High

    Established IQGAP2 as a Cdc42/Rac1-selective effector that, unexpectedly, inhibits rather than stimulates GTP hydrolysis, defining it as a non-catalytic GTPase scaffold rather than a true GAP.

    Evidence Domain analysis, calmodulin- and GTPase-binding assays, and GTP hydrolysis assays with truncation mutants; cytosol pulldown with microsequencing and competition assays using GTPase chimeras

    PMID:8702968 PMID:8756646

    Open questions at the time
    • No structural basis for the hydrolysis inhibition
    • Functional consequence of stabilizing GTP-bound Cdc42/Rac1 in cells not defined
    • F-actin binding by the CH domain inferred, not directly demonstrated
  2. 2002 High

    Showed that IQGAP2 functions as an agonist-specific cytoskeletal effector, linking Rac1-GTP to actin polymerization machinery in activated platelets.

    Evidence Reciprocal co-IP, immunofluorescence, subcellular fractionation, and platelet activation assays with agonist specificity controls

    PMID:12515716

    Open questions at the time
    • Direct vs. indirect association with Arp2/3 not resolved
    • Mechanism of thrombin-specific recruitment unknown
  3. 2007 High

    Demonstrated an in vivo requirement for IQGAP2 in cadherin-mediated cell-cell adhesion, connecting its cytoskeletal role to junction assembly.

    Evidence Morpholino knockdown in Xenopus embryos with histology, immunofluorescence, and Ca2+-induced reaggregation assays

    PMID:17617398

    Open questions at the time
    • Molecular partner at the junction not identified in this system
    • Morpholino off-target effects not excluded
  4. 2008 High

    Defined IQGAP2 as a tumor suppressor that restrains IQGAP1, with the hepatocellular carcinoma phenotype of its loss genetically dependent on IQGAP1.

    Evidence Iqgap2 knockout and Iqgap1/Iqgap2 double-knockout epistasis, co-IP of endogenous E-cadherin/beta-catenin/IQGAP1 complex, immunofluorescence and Western blotting

    PMID:18180285

    Open questions at the time
    • Direct IQGAP1-IQGAP2 interaction not detected here (later reconciled)
    • How IQGAP2 loss elevates IQGAP1 unresolved
  5. 2011 Medium

    Refined the calmodulin-binding code of IQGAP2 and extended its role to hepatic fatty-acid handling, broadening its metabolic functions.

    Evidence Synthetic IQ-motif peptide binding assays with native gels and modelling; Iqgap2 knockout mouse LCFA uptake assays distinguishing facilitated vs. diffusional phases

    PMID:21299499 PMID:21968151

    Open questions at the time
    • Peptide assays do not reflect full-length protein
    • Molecular link between IQGAP2 and the fatty-acid transport apparatus undefined
  6. 2015 Medium

    Extended IQGAP2's adhesion/cytoskeletal function to organ physiology (podocyte filtration) and uncovered a pro-inflammatory role via TLR4/NF-kB in colonic epithelium.

    Evidence Zebrafish morpholino knockdown with dextran permeability assays; Iqgap2 knockout mouse DSS colitis model with NF-kB and cytokine readouts

    PMID:26047140 PMID:26154927

    Open questions at the time
    • Direct molecular targets in podocytes and colonocytes not identified
    • Whether the inflammatory role is cell-autonomous in epithelium unresolved
  7. 2016 Medium

    Identified a JAK-STAT-independent antiviral signaling role in which IQGAP2 physically partners with RelA to drive a subset of interferon-stimulated genes.

    Evidence siRNA knockdown, IQGAP2-RelA co-IP, NF-kB reporter assays, and HCV infection assay in hepatoma cells

    PMID:27401546

    Open questions at the time
    • Structural basis of IQGAP2-RelA interaction unknown
    • Which ISG subset and promoter logic not fully defined
  8. 2018 Medium

    Provided a structural-dynamic model explaining differential Cdc42 vs. Rac1 engagement and IQGAP2 dimerization, linking GTPase insert-loop differences to oligomerization.

    Evidence All-atom molecular dynamics simulations validated by site-directed mutagenesis and Western blotting

    PMID:29358323

    Open questions at the time
    • No experimentally solved structure
    • Functional role of IQGAP2 dimerization in cells untested
  9. 2020 Medium

    Established a mechanism for IQGAP2 tumor suppression through activation of SHIP2 phosphatase to inactivate Akt and reduce EMT.

    Evidence Co-IP with mass spectrometry, SHIP2 domain-deletion mapping, phosphatase activity assays, and migration/invasion assays in gastric cancer cells

    PMID:32183047

    Open questions at the time
    • How IQGAP2 binding elevates SHIP2 catalytic activity mechanistically unclear
    • Single cancer-cell context
  10. 2021 Medium

    Resolved the long-standing question of direct IQGAP1-IQGAP2 contact and tied it to ERK suppression, plus identified IQGAP2 as a small-molecule (isoliquiritigenin) target in a CREB-SIRT1 metabolic axis.

    Evidence Pull-down assay with overexpression rescue and xenograft model; LiP-SMap target identification with siRNA rescue and phospho-kinase arrays

    PMID:33846302 PMID:33860590

    Open questions at the time
    • Sequestration model not quantified stoichiometrically
    • How ISO binding alters IQGAP2 function mechanistically undefined
  11. 2023 Medium

    Expanded IQGAP2's interactome and roles to insulin-dependent glycogen synthesis (GSK3/GYS), mTOR/AKT proliferation control, and an EBV Rta-driven lytic-cycle program in which IQGAP2 is both a transcriptional target and a nuclear binding partner.

    Evidence Co-IP from mouse liver with knockout phenotyping; siRNA with multi-omics and inhibitor rescue; ChIP/promoter binding, co-IP, nuclear co-localization and luciferase reporters

    PMID:37154877 PMID:37504571 PMID:37805137

    Open questions at the time
    • Whether GSK3/GYS binding is direct vs. complex-mediated unclear
    • Nuclear pool of IQGAP2 and its function poorly defined
    • Reconciliation of cytoplasmic scaffold vs. nuclear Rta partner not addressed
  12. 2024 Medium

    Connected IQGAP2 to apical solute-transporter stabilization (hcTPPT) and to a transcriptional regulatory circuit (ALDH9A1-NPM1) that gates AKT-mTOR signaling in renal carcinoma.

    Evidence Yeast two-hybrid, co-IP, co-localization, knockdown/overexpression with TPP uptake assays; RNA-seq, IP, luciferase reporters and in vivo functional assays in ccRCC

    PMID:39039052 PMID:39401425

    Open questions at the time
    • Generality of transporter-stabilization role beyond hcTPPT unknown
    • Direct vs. indirect control of IQGAP2 transcription by NPM1 not fully resolved
  13. 2025 Medium

    Established IQGAP2 as a regulator of blood-brain barrier immune privilege, suppressing endothelial adhesion-receptor and antigen-processing expression to limit CNS leukocyte infiltration.

    Evidence Iqgap2 knockout mice and zebrafish knockdown with single-cell RNA-seq, immunohistology, and leukocyte infiltration quantification

    PMID:40071147

    Open questions at the time
    • Endothelial molecular targets downstream of IQGAP2 not pinned to a single pathway
    • Cell-autonomous mechanism in brain endothelium not fully dissected

Open questions

Synthesis pass · forward-looking unresolved questions
  • How IQGAP2's diverse molecular activities—GTPase scaffolding, actin/calmodulin binding, IQGAP1 sequestration, and multiple signaling partnerships—are coordinated within and across cell types to produce its context-specific tumor-suppressive, metabolic, and barrier functions remains unresolved.
  • No experimentally solved full-length structure
  • No unifying model linking cytoplasmic scaffold and nuclear roles
  • Whether GTPase regulation underlies the tumor-suppressive and metabolic phenotypes is untested

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 3 GO:0005198 structural molecule activity 2 GO:0008092 cytoskeletal protein binding 2
Localization
GO:0005829 cytosol 2 GO:0005886 plasma membrane 2 GO:0005634 nucleus 1 GO:0005856 cytoskeleton 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-168256 Immune System 3 R-HSA-1430728 Metabolism 2 R-HSA-1500931 Cell-Cell communication 2
Partners
CDC42CDH1CTNNB1GSK3INPPL1IQGAP1RAC1RELA
Complex memberships
IQGAP1/IQGAP2/beta-catenin/E-cadherin scaffoldIQGAP2/Arp2/3/actin complex

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 IQGAP2 harbors an N-terminal calponin homology domain that functions as a potential F-actin binding domain, and binds calmodulin via IQ motifs; it binds Cdc42 and Rac1 (but not RhoA) through its C-terminal half in a nucleotide-status-independent manner and inhibits both intrinsic and RhoGAP-stimulated GTP hydrolysis by Cdc42 and Rac1 without acting as a GAP. Domain analysis, calmodulin-binding assays, GTPase binding assays, GTP hydrolysis assays, truncation mutants Molecular and cellular biology High 8756646
1996 IQGAP2 (identified as p175 from rabbit liver cytosol) binds preferentially to Cdc42 and Rac1 but not RhoA or Ha-Ras; binding requires both the switch I domain and an insert region unique to Rho GTPases, and is competed by the Cdc42-binding domain of mPAK-3 but not by Cdc42-GAP. Cytosol pulldown, microsequencing, competition assays with GTPase mutants and chimeras The Journal of biological chemistry High 8702968
2002 In thrombin-activated platelets, IQGAP2 assembles into a cytoplasmic complex with Arp2/3 and actin, an association regulated by GTP-bound Rac1 but not GTP-bound Cdc42; IQGAP2 translocates to the platelet cytoskeleton specifically upon thrombin (not collagen or ADP) activation, and colocalizes with F-actin in lamellipodia and filopodia of transfected COS1 cells. Immunofluorescence microscopy, co-immunoprecipitation, platelet activation assays, subcellular fractionation Blood High 12515716
2007 Morpholino knockdown of XIQGAP2 in Xenopus laevis embryos causes loss of actin filaments, beta-catenin, and XIQGAP1 from cell borders in the ectoderm and inhibits Ca2+-induced reaggregation of dissociated embryonic cells, establishing that IQGAP2 is required for cadherin-mediated cell-to-cell adhesion. Morpholino antisense knockdown, histology, immunofluorescence, Ca2+-induced cell reaggregation assay Developmental biology High 17617398
2008 Targeted disruption of murine Iqgap2 leads to overexpression of IQGAP1, loss of membrane E-cadherin, cytoplasmic translocation and activation of beta-catenin, and overexpression of cyclin D1; IQGAP2 normally exists in a scaffolding complex with IQGAP1, beta-catenin, and E-cadherin in hepatocytes (no direct IQGAP1–IQGAP2 interaction detected); crossing Iqgap2−/− onto Iqgap1−/− background rescues HCC phenotype, establishing epistatic dependence of the HCC phenotype on IQGAP1. Gene knockout, genetic epistasis (double KO), co-immunoprecipitation, immunofluorescence, Western blotting Molecular and cellular biology High 18180285
2011 The IQ-motifs of IQGAP2 show selectivity for calmodulin: IQ motifs 2 and 3 interact with calmodulin in the presence of calcium ions, while IQ motif 1 forms only a transient interaction with calmodulin in the absence of calcium; none of the IQGAP2 IQ motifs interact with S100B. Synthetic peptide binding assays, native gel electrophoresis, molecular modelling Bioscience reports Medium 21299499
2011 Iqgap2-deficient mice show selective loss of the facilitated (carrier-assisted) phase of hepatocyte long-chain fatty acid (LCFA) uptake, with preservation of the diffusional component, implicating IQGAP2 in an intracellular signaling pathway required for functional fatty acid uptake. Iqgap2 knockout mouse, LCFA uptake assays in isolated hepatocytes (facilitated vs. diffusional phases), high-fat diet feeding Regulatory peptides Medium 21968151
2015 IQGAP2 is required for normal podocyte structure and glomerular filtration; morpholino knockdown of iqgap2 in zebrafish causes foot process effacement and loss of size-selective glomerular filtration, demonstrated by permeability to high-molecular-weight dextrans. Morpholino knockdown in zebrafish, immunohistochemistry, in situ hybridization, dextran permeability assay Kidney international Medium 26154927
2015 IQGAP2 promotes colonic inflammatory response via TLR4/NF-κB signaling locally in colonic epithelium; Iqgap2−/− mice are resistant to DSS-induced colitis, showing suppressed NF-κB signaling, reduced IL-6, and diminished neutrophil/macrophage production and recruitment. Iqgap2 knockout mouse, DSS colitis model, NF-κB signaling assays, cytokine measurements, histology PloS one Medium 26047140
2016 IQGAP2 acts downstream of IFN-α receptor binding, independently of the JAK-STAT pathway, by physically interacting with RelA (NF-κB p65 subunit); both IQGAP2 and RelA are required for IFN-stimulated induction of a subset of antiviral ISGs in hepatoma cells. siRNA knockdown, co-immunoprecipitation (IQGAP2–RelA), HCV infection assay, NF-κB reporter assays Journal of hepatology Medium 27401546
2018 Using all-atom MD simulations validated by site-directed mutagenesis, two Cdc42 molecules can bind simultaneously to IQGAP2: one via the Ex-domain of the GRD (requiring Cdc42's insert loop) and one via the RasGAP site, with the first binding event driving allosteric changes that facilitate the second binding and promote IQGAP2 dimerization; Rac1, due to differences in its insert loop, can only bind the RasGAP site and cannot facilitate IQGAP2 dimerization. All-atom molecular dynamics simulations, site-directed mutagenesis, Western blotting The Journal of biological chemistry Medium 29358323
2020 IQGAP2 interacts with SHIP2 (via SHIP2's PRD and SAM domains) in the cytoplasm of gastric cancer cells; this interaction elevates SHIP2 phosphatase activity, thereby inactivating Akt and reducing EMT-driven migration and invasion. Co-immunoprecipitation, mass spectrometry, domain deletion mutants, SHIP2 phosphatase activity assay, siRNA knockdown, migration/invasion assays International journal of molecular sciences Medium 32183047
2021 Using limited proteolysis–mass spectrometry (LiP-SMap), IQGAP2 was identified as a direct binding target of isoliquiritigenin (ISO); through this interaction, ISO promotes phosphorylation of CREB, which upregulates SIRT1 expression, defining a novel IQGAP2-CREB-SIRT1 axis that reduces lipid accumulation in NAFLD. LiP-SMap (limited proteolysis combined with mass spectrometry), siRNA knockdown, phospho-kinase array, Western blotting Phytotherapy research Medium 33860590
2021 IQGAP2 suppresses IQGAP1-mediated ERK activation; pull-down assay confirmed direct IQGAP1–IQGAP2 interaction, and IQGAP2 overexpression rescued IQGAP1-driven ERK phosphorylation, suggesting IQGAP1 sequestration as a mechanism; IQGAP2 also enhances apoptosis via ROS–P38–p53 pathway and reduces EMT via MEK-ERK inhibition. Pull-down assay, Western blotting, siRNA/overexpression, tumor xenograft model Cell death & disease Medium 33846302
2023 IQGAP2 immunoprecipitation from mouse liver revealed interaction with glycogen synthase kinase 3 (GSK3) and glycogen synthase (GYS); IQGAP2 knockout mice in the fed state showed decreased phosphorylated GSK3α and total GYS protein, reduced periportal glycogen, and impaired AKT and FOXO3 phosphorylation downstream of insulin signaling. Immunoprecipitation, knockout mouse model, Western blotting, glycogen staining, in vitro siRNA knockdown The Journal of biological chemistry Medium 37805137
2023 EBV transcription factor Rta binds directly to an Rta-responsive element (RRE) in the IQGAP2 promoter to upregulate IQGAP2 expression; Rta and IQGAP2 physically interact and co-localize in the nucleus; IQGAP2 is required for Rta-mediated activation of the Rta promoter and influences E-cadherin expression and cell clumping morphology in lymphoblastoid cells. ChIP/promoter binding assay, co-immunoprecipitation, co-localization (immunofluorescence), siRNA knockdown, luciferase reporter assay Journal of virology Medium 37504571
2023 IQGAP2 knockdown in HaCaT and HEK293 cells increases phosphorylation of AKT and S6K, activating the mTOR pathway and increasing cell proliferation; AKT and mTOR inhibitors partially rescue the proliferation phenotype caused by IQGAP2 deficiency. siRNA knockdown, multi-omics (transcriptome, proteome, phosphoproteome), inhibitor rescue experiments Human cell Medium 37154877
2024 IQGAP2 colocalizes and directly interacts with the human colonic thiamin pyrophosphate transporter (hcTPPT) at the apical membrane of colonocytes; IQGAP2 overexpression enhances TPP uptake and hcTPPT protein stability, while IQGAP2 knockdown reduces TPP uptake. Yeast two-hybrid screen, co-immunoprecipitation, fluorescence microscopy co-localization, siRNA knockdown, overexpression in NCM460 cells and colonoid monolayers, TPP uptake assay American journal of physiology. Cell physiology Medium 39401425
2024 In clear cell renal cell carcinoma, ALDH9A1 sequesters NPM1 in the cytoplasm, which in turn allows NPM1 to support IQGAP2 transcription; loss of ALDH9A1 releases NPM1 from the cytoplasm, suppresses IQGAP2 expression, and activates AKT-mTOR signaling to promote tumor progression. RNA sequencing, mass spectrometry, immunoprecipitation, luciferase reporter assay, mutational studies, immunofluorescence, in vitro and in vivo functional assays Cell death & disease Medium 39039052
2025 Loss of Iqgap2 in mice and zebrafish increases infiltration of peripheral leukocytes into the CNS under homeostatic and inflammatory conditions; brain endothelial cells from Iqgap2-knockout mice show extensive upregulation of adhesion receptors and antigen-processing machinery, establishing IQGAP2 as a regulator of blood-brain barrier immune privilege. Iqgap2 knockout mice, zebrafish knockdown, single-cell RNA sequencing, immunohistology, leukocyte infiltration quantification iScience Medium 40071147

Source papers

Stage 0 corpus · 41 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1996 The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. Molecular and cellular biology 233 8756646
1996 Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2. The Journal of biological chemistry 132 8702968
2008 Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent. Molecular and cellular biology 109 18180285
2010 IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma. BMC gastroenterology 63 20977743
2012 IQGAP2, A candidate tumour suppressor of prostate tumorigenesis. Biochimica et biophysica acta 50 22406297
2008 IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells. International journal of cancer 48 17957782
2002 IQGAP2 functions as a GTP-dependent effector protein in thrombin-induced platelet cytoskeletal reorganization. Blood 47 12515716
2021 Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status. Cell death & disease 41 33846302
2016 Anti-inflammatory effect of miltirone on inflammatory bowel disease via TLR4/NF-κB/IQGAP2 signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 41 27903427
2018 Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2. The Journal of biological chemistry 39 29358323
2015 Epigenetic regulation of IQGAP2 promotes ovarian cancer progression via activating Wnt/β-catenin signaling. International journal of oncology 36 26549344
2020 Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as noninvasive biomarkers of primary Sjögren's syndrome. Rheumatology (Oxford, England) 35 32250392
2021 Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2-CREB-SIRT1 axis. Phytotherapy research : PTR 28 33860590
2011 IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain. Bioscience reports 28 21299499
2020 LncRNA PDCD4-AS1 alleviates triple negative breast cancer by increasing expression of IQGAP2 via miR-10b-5p. Translational oncology 25 33248413
2020 IQGAP2 Inhibits Migration and Invasion of Gastric Cancer Cells via Elevating SHIP2 Phosphatase Activity. International journal of molecular sciences 24 32183047
2013 Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma. PloS one 22 23951254
2016 IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-κB pathway. Journal of hepatology 21 27401546
2015 IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice. PloS one 21 26047140
2007 IQGAP2 is required for the cadherin-mediated cell-to-cell adhesion in Xenopus laevis embryos. Developmental biology 21 17617398
2018 Downregulation of IQGAP2 Correlates with Prostate Cancer Recurrence and Metastasis. Translational oncology 19 30428404
2014 Role of the tumor suppressor IQGAP2 in metabolic homeostasis: Possible link between diabetes and cancer. Metabolomics : Official journal of the Metabolomic Society 19 25254002
2023 The Antithetic Roles of IQGAP2 and IQGAP3 in Cancers. Cancers 18 36831467
2022 Reduced IQGAP2 Promotes Bladder Cancer through Regulation of MAPK/ERK Pathway and Cytokines. International journal of molecular sciences 18 36362301
2011 Ablation of Iqgap2 protects from diet-induced hepatic steatosis due to impaired fatty acid uptake. Regulatory peptides 17 21968151
2017 Altered methylation of specific DNA loci in the liver of Bhmt-null mice results in repression of Iqgap2 and F2rl2 and is associated with development of preneoplastic foci. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 16 28179424
2015 The Rho-GTPase binding protein IQGAP2 is required for the glomerular filtration barrier. Kidney international 16 26154927
2022 Long non-coding ribonucleic acid ATP2B1-AS1 modulates endothelial permeability through regulating the miR-4729-IQGAP2 axis in diabetic retinopathy. Journal of diabetes investigation 10 34935307
2016 Integrated genomic profiling identifies microRNA-92a regulation of IQGAP2 in locally advanced rectal cancer. Genes, chromosomes & cancer 9 26865277
2004 Cloning and characterization of a novel transcript variant of IQGAP2 in human testis. DNA sequence : the journal of DNA sequencing and mapping 8 15621655
2024 N6-methyladenosine-modified ALDH9A1 modulates lipid accumulation and tumor progression in clear cell renal cell carcinoma through the NPM1/IQGAP2/AKT signaling pathway. Cell death & disease 7 39039052
2025 IQGAP2 regulates blood-brain barrier immune dynamics. iScience 6 40071147
2023 Depletion of IQ motif-containing GTPase activating protein 2 (IQGAP2) reduces hepatic glycogen and impairs insulin signaling. The Journal of biological chemistry 6 37805137
2023 Upregulation of IQGAP2 by EBV transactivator Rta and its influence on EBV life cycle. Journal of virology 4 37504571
2015 The European GWAS-identified risk SNP rs457717 within IQGAP2 is not associated with age-related hearing impairment in Han male Chinese population. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 4 26187738
2024 Polymorphisms Within the IQGAP2 and CRTAC1 Genes of Gannan Yaks and Their Association with Milk Quality Characteristics. Foods (Basel, Switzerland) 3 39682792
2024 IQGAP-2: a novel interacting partner with the human colonic thiamin pyrophosphate transporter. American journal of physiology. Cell physiology 1 39401425
2025 Unveiling the therapeutic potential of senescence-related IQGAP2 in pancreatic Cancer through post-GWAS genomic and scRNA-seq analyses. Discover oncology 0 40640432
2024 IQGAP2 regulates blood-brain barrier immune dynamics. bioRxiv : the preprint server for biology 0 38645082
2023 Multi-omics data integration reveals the molecular network of dysregulation IQGAP2-mTOR promotes cell proliferation. Human cell 0 37154877
2022 Transcriptome analysis of PBMCs isolated from piglets treated with a miR-124 sponge construct identified miR124/IQGAP2/Rho GTPase as a target pathway support Salmonella Typhimurium infection. Molecular genetics and genomics : MGG 0 36380106

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