Affinage

ING2

Inhibitor of growth protein 2 · UniProt Q9H160

Length
280 aa
Mass
32.8 kDa
Annotated
2026-04-28
47 papers in source corpus 24 papers cited in narrative 24 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ING2 is a chromatin-regulatory tumor suppressor that integrates histone mark recognition, nuclear lipid signaling, and transcriptional repression to control cell proliferation, DNA damage responses, and differentiation. Its PHD domain binds H3K4me3/me2 with high affinity and simultaneously senses the nuclear phosphoinositide PtdIns(5)P, directing the mSin3A–HDAC1 repressive complex to target promoters such as p21 and proliferation genes in response to DNA damage (PMID:16728974, PMID:12859901, PMID:23823870). ING2 also scaffolds p53–p300 interaction through its N-terminal leucine zipper–like motif, promoting p53 acetylation at Lys-382 to activate p53-dependent apoptosis, senescence, and nucleotide excision repair (PMID:11481424, PMID:16024799, PMID:16782091). Beyond nuclear chromatin functions, ING2 translocates to mitochondria in a redox-sensitive manner, where it maintains respiratory chain activity by stabilizing MRPL12 and interacting with mtDNA via TFAM (PMID:34017078, PMID:34434929).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2001 High

    Establishing ING2 as a p53 activator resolved how the ING family connects to the p53 tumor-suppressive pathway: ING2 enhances p53 transcriptional activity and acetylation at Lys-382, driving G1 arrest and apoptosis after DNA damage.

    Evidence Overexpression, p53 transcriptional reporter, acetylation Western blot, cell cycle and apoptosis assays in human cells

    PMID:11481424

    Open questions at the time
    • Acetyltransferase responsible not identified
    • Endogenous complex stoichiometry unknown
    • Mechanism linking ING2 to p53 acetylation not defined
  2. 2003 High

    Demonstrating that the ING2 PHD finger binds PtdIns(5)P in the nucleus revealed a novel nuclear phosphoinositide signaling input that governs ING2's p53-activating and apoptotic functions.

    Evidence Lipid-binding assays (in vitro and in vivo), PHD finger mutagenesis, p53 activation assays

    PMID:12859901

    Open questions at the time
    • Enzymes controlling nuclear PtdIns(5)P pools not linked to ING2 regulation
    • Whether PtdIns(5)P and H3K4me binding are mutually exclusive or cooperative unknown
  3. 2005 High

    Identification of a p53–ING2–p300 ternary complex explained the acetylation mechanism: ING2 scaffolds p300-mediated p53 acetylation, linking this to replicative senescence.

    Evidence Reciprocal co-immunoprecipitation, siRNA knockdown, senescence assays

    PMID:16024799

    Open questions at the time
    • ING2–p300 binding interface not mapped
    • Whether ING2 directs p300 to chromatin versus soluble p53 unclear
  4. 2006 High

    Structural and biochemical resolution of H3K4me3 recognition by the PHD domain, combined with its role in tethering the mSin3A–HDAC1 complex to promoters, established ING2 as a histone-mark reader linking active chromatin marks to transcriptional repression.

    Evidence 2.0 Å crystal structure, binding assays, aromatic cage mutagenesis (Y215/W238), ChIP, Co-IP with mSin3A–HDAC1

    PMID:16728974 PMID:16728977

    Open questions at the time
    • How a mark of active transcription (H3K4me3) is reconciled with repressive HDAC recruitment not fully resolved
    • Genome-wide binding profile not determined
  5. 2006 Medium

    ING2 was placed upstream of chromatin remodeling in UV-induced nucleotide excision repair, showing it promotes histone H4 acetylation, chromatin relaxation, and XPA recruitment to photolesions, with the leucine zipper–like motif essential for p53 association and repair.

    Evidence Host-cell reactivation assay, siRNA, histone acetylation and chromatin accessibility assays, domain deletion mutagenesis

    PMID:16488987 PMID:16782091

    Open questions at the time
    • Whether ING2 directly recruits a HAT for H4 acetylation in NER unknown
    • Repair function not validated by in vivo damage assays in knockout models
  6. 2008 Medium

    Discovery that ING2 participates in TGF-β signaling through a SnoN–ING2–Smad2 complex broadened its role beyond p53 to include Smad-dependent transcription and cell cycle arrest.

    Evidence Co-immunoprecipitation, siRNA, transcriptional reporter assays

    PMID:18334480

    Open questions at the time
    • Chromatin target genes of the SnoN–ING2–Smad2 complex not defined
    • Whether the Sin3A–HDAC1 complex is involved in this axis unclear
  7. 2009 Medium

    Linking ING2 to PCNA and DNA replication fork progression revealed a replication-intrinsic function: ING2 controls PCNA loading onto chromatin, and its loss causes reduced replication rate, endoreduplication, and sister chromatid exchange.

    Evidence DNA fiber spreading, co-immunoprecipitation, chromatin fractionation, siRNA

    PMID:19730436

    Open questions at the time
    • Mechanism by which ING2 promotes PCNA loading not resolved
    • Whether PHD domain H3K4me3 reading is required for replication function unknown
  8. 2010 Medium

    Post-translational regulation of ING2 was defined: SUMO1 modification at K195 enhances Sin3A binding and promoter occupancy, while Smurf1-mediated ubiquitination targets ING2 for proteasomal degradation, revealing opposing PTM switches that tune ING2 activity.

    Evidence In vitro and in vivo sumoylation/ubiquitination assays, mutagenesis, Co-IP, ChIP, proteasome inhibitor treatment

    PMID:20621832 PMID:20676127

    Open questions at the time
    • Signals triggering Smurf1-mediated degradation not identified
    • Interplay between sumoylation and ubiquitination not examined
  9. 2010 High

    Ing2 knockout mice developed soft-tissue sarcomas and male infertility with meiotic arrest and deregulated chromatin acetylation, providing in vivo genetic proof of tumor suppressor function and a requirement for HDAC1-mediated chromatin regulation in spermatogenesis.

    Evidence Germline knockout, histopathology, p53 double-knockout rescue, immunofluorescence

    PMID:21124965

    Open questions at the time
    • Tumor spectrum and latency not fully characterized
    • Direct transcriptional targets in spermatogenesis not identified
  10. 2013 Medium

    Genome-level demonstration that PtdIns(5)P binding is required for ING2 promoter occupancy at a subset of DNA damage–responsive targets refined the lipid-signaling model from a general activator to a site-selective chromatin-targeting mechanism.

    Evidence ChIP combined with PtdIns(5)P depletion and lipid-binding assays

    PMID:23823870

    Open questions at the time
    • Full repertoire of PtdIns(5)P-dependent ING2 target genes not mapped
    • Whether PtdIns(5)P binding alters PHD domain conformation not resolved
  11. 2021 Medium

    Discovery of ING2 translocation to mitochondria, where it interacts with mtDNA via TFAM and stabilizes MRPL12 to maintain OXPHOS, revealed a non-nuclear function that extends ING2's role to mitochondrial homeostasis.

    Evidence Subcellular fractionation, Co-IP with TFAM and MRPL12, OCR assay, electron microscopy, siRNA, kidney-specific in vivo overexpression

    PMID:34017078 PMID:34434929

    Open questions at the time
    • Mitochondrial import signal or translocase pathway not identified
    • Whether mitochondrial ING2 retains PHD-dependent functions unknown
    • Physiological stimuli triggering mitochondrial translocation beyond redox changes not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • The interplay between ING2's nuclear chromatin functions and its mitochondrial roles, the full genome-wide target repertoire of ING2-associated repressive complexes, and how PtdIns(5)P and H3K4me3 binding are coordinated on the same PHD domain remain unresolved.
  • No genome-wide occupancy map integrating histone mark and lipid-dependent targeting
  • Structural basis for dual PHD ligand recognition (H3K4me3 vs PtdIns(5)P) not determined
  • Relative contribution of nuclear vs mitochondrial ING2 to tumor suppression unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0140110 transcription regulator activity 4 GO:0008289 lipid binding 2 GO:0042393 histone binding 2
Localization
GO:0005634 nucleus 5 GO:0005694 chromosome 3 GO:0005739 mitochondrion 2
Pathway
R-HSA-4839726 Chromatin organization 5 R-HSA-5357801 Programmed Cell Death 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-1640170 Cell Cycle 2 R-HSA-73894 DNA Repair 2 R-HSA-162582 Signal Transduction 1 R-HSA-69306 DNA Replication 1
Partners
EP300HDAC1MRPL12PCNASIN3ASMURF1TFAMTP53
Complex memberships
SnoN-ING2-Smad2mSin3A-HDAC1p53-p300-ING2

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 The PHD domain of ING2 is a specific, high-affinity binding module for trimethylated and dimethylated histone H3 lysine 4 (H3K4me3/me2), and ING2 as a native subunit of the mSin3a-HDAC1 histone deacetylase complex uses this interaction to stabilize the repressive complex at promoters of proliferation genes in response to DNA damage. Biochemical binding assays, co-immunoprecipitation, chromatin immunoprecipitation, loss-of-function experiments with PHD domain mutants Nature High 16728974
2006 Crystal structure (2.0 Å) of the mouse ING2 PHD finger in complex with H3K4me3 peptide revealed that trimethylated Lys4 is recognized by aromatic cage residues Y215 and W238, and mutagenesis of these binding-site residues disrupts H3K4me3 interaction in vitro and impairs ING2-induced apoptosis in vivo. X-ray crystallography, in vitro binding assays, site-directed mutagenesis, apoptosis assay Nature High 16728977
2003 The PHD finger of ING2 binds phosphoinositides, particularly phosphatidylinositol 5-phosphate (PtdIns(5)P), in vitro and in vivo in the nucleus, and this interaction regulates ING2's ability to activate p53 and p53-dependent apoptotic pathways. Lipid-binding assays, in vivo PtdIns(5)P interaction, p53 activation assays, PHD finger mutagenesis Cell High 12859901
2001 ING2 (p33ING2) enhances p53 transcriptional activity and increases acetylation of p53 at Lys-382, negatively regulating cell growth through p53-dependent G1 cell cycle arrest and apoptosis in response to DNA damage. Overexpression, p53 transcriptional assay, Western blot for acetylated p53, cell cycle analysis, apoptosis assay Proceedings of the National Academy of Sciences of the United States of America High 11481424
2005 ING2 complexes with p53 and the histone acetyltransferase p300, enhancing their interaction and acting as a cofactor for p300-mediated acetylation of p53, thereby promoting p53-dependent replicative senescence. Co-immunoprecipitation, siRNA knockdown, overexpression, senescence assays Molecular and cellular biology High 16024799
2010 HDAC inhibitor SAHA causes dissociation of ING2 from the Sin3 deacetylase complex, and loss of ING2 disrupts in vivo binding of the Sin3 complex to the p21 promoter. Mass spectrometry of complex composition after SAHA treatment, chromatin immunoprecipitation Chemistry & biology Medium 20142042
2006 ING2 is required for UV-induced nucleotide excision repair in melanoma cells; it promotes rapid histone H4 acetylation, chromatin relaxation, and recruitment of damage-recognition protein XPA to photolesions, functioning upstream of chromatin remodeling in NER. Host-cell reactivation assay, siRNA knockdown, histone acetylation assay, chromatin accessibility assay, XPA recruitment by ChIP/immunofluorescence Cancer research Medium 16488987
2006 The leucine zipper-like (LZL) motif in the N-terminus of ING2 is required for association with p53 (but not p300), and its deletion abolishes ING2-dependent DNA repair, apoptosis, and chromatin remodeling after UV irradiation, placing ING2 as a scaffold mediating p53–p300 interaction. Deletion mutagenesis, co-immunoprecipitation, host-cell reactivation assay, apoptosis assay FEBS letters Medium 16782091
2008 ING2 promotes TGF-β-induced transcription and cell cycle arrest; it interacts with the transcriptional modulator SnoN to form a complex with SnoN–ING2–Smad2, and SnoN is required for ING2-mediated enhancement of TGF-β/Smad-dependent transcription. Co-immunoprecipitation, siRNA knockdown, overexpression, transcriptional reporter assays The Journal of biological chemistry Medium 18334480
2010 ING2 is sumoylated by SUMO1 on lysine 195 both in vitro and in vivo, and this sumoylation enhances ING2 association with Sin3A and is required for ING2 binding to specific gene promoters (e.g., TMEM71) to mediate Sin3A/HDAC-dependent transcriptional repression. In vitro sumoylation assay, in vivo SUMO modification, co-immunoprecipitation, chromatin immunoprecipitation, mutagenesis Oncogene Medium 20676127
2010 The HECT-type ubiquitin ligase Smurf1 directly interacts with ING2 via its HECT domain, polyubiquitinates ING2 requiring the C-terminal PHD domain of ING2, and targets ING2 for proteasomal degradation. Co-immunoprecipitation, ubiquitination assay, proteasome inhibitor treatment, domain mapping FEBS letters Medium 20621832
2009 ING2 interacts with proliferating cell nuclear antigen (PCNA) and regulates PCNA loading onto chromatin, controlling DNA replication fork progression; ING2 depletion reduces global replication rate and causes endoreduplication and increased sister chromatid exchange. DNA fiber spreading assay, co-immunoprecipitation, chromatin fractionation, siRNA knockdown EMBO reports Medium 19730436
2013 Direct association of ING2 with nuclear phosphatidylinositol-5-phosphate (PtdIns(5)P) is required for ING2 promoter occupancy and ING2-associated gene repression at a subset of genomic targets in response to DNA damage; PtdIns(5)P depletion attenuates ING2-mediated gene regulation at these sites. Chromatin immunoprecipitation, PtdIns(5)P depletion, lipid-binding assays Scientific reports Medium 23823870
2008 ING2 associates with histone methyltransferase (HMT) activity in vitro and in vivo, methylating histone H3 at a site distinct from K9 but dependent on the methylation state of K4; this HDAC-independent silencing function maps to the ING2 C-terminus. In vitro HMT assay, co-immunoprecipitation, deletion and mutation analysis, reporter silencing assay with TSA Biochimica et biophysica acta Medium 18513492
2010 ING2 knockout mice develop soft-tissue sarcomas and show male infertility due to meiotic arrest; in Ing2-null testes, HDAC1 accumulation is lost and chromatin acetylation is deregulated, establishing that ING2 functions through both p53-dependent and chromatin (HDAC1/H3K4me3)-mediated mechanisms in spermatogenesis. Targeted germline knockout, histopathology, immunofluorescence, p53 double-knockout rescue PloS one High 21124965
2010 ING2 regulates the G1/S transition by maintaining p21 expression independently of p53; ING2 knockdown accelerates G1-to-S progression and decreases p21 levels, a function not shared by its homolog ING1. siRNA knockdown, flow cytometry cell cycle analysis, Western blot/qPCR for p21 Cell cycle (Georgetown, Tex.) Medium 20890119
2012 ING2 is required for C2C12 myoblast differentiation into myotubes; the leucine zipper motif of ING2 promotes differentiation while the PHD domain inhibits it, and the Sin3A-HDAC1 complex that interacts with ING2 is essential for ING2-dependent myogenesis. RNAi knockdown, overexpression of domain mutants, myotube formation assay, Co-IP of Sin3A-HDAC1 PloS one Medium 22808232
2009 ING2 regulates cell death in response to the alkylating agent MNNG through a MMR/c-Abl→ING2→p73α signaling axis; ING2 induction is dependent on MLH1 and c-Abl, and ING2 associates with p73α in the nucleus, promoting its stabilization and acetylation. shRNA knockdown, co-immunoprecipitation, nuclear localization assay, c-Abl inhibitor (STI571), acetylation Western blot Experimental cell research Medium 19766113
2009 ING2 upregulation in colon cancer drives MMP13 expression and enhances cellular invasion; this regulation of MMP13 is mediated by the ING2-HDAC1-mSin3A complex, as co-expression of these complex members further induces MMP13. Microarray, siRNA knockdown, overexpression, in vitro invasion assay, EMSA/luciferase for NF-κB binding to ING2 promoter International journal of cancer Medium 19437536
2021 ING2 translocates into the inner mitochondrial fraction in a redox-sensitive manner modulated by 14-3-3η protein; mitochondrial ING2 interacts with mtDNA via TFAM and is required for normal mitochondrial ultrastructure and mitochondrial respiration/OXPHOS activity. Subcellular fractionation, immunoprecipitation, co-IP with TFAM, oxygen consumption rate assay, siRNA knockdown, electron microscopy Oncogene Medium 34017078
2021 In renal tubular epithelial cells, ING2 controls mitochondrial respiration by regulating ubiquitination and stability of the mitochondrial transcription factor MRPL12, thereby modulating mtDNA-encoded respiratory chain component expression. Co-immunoprecipitation, ubiquitination assay, oxygen consumption rate assay, ING2 overexpression in vivo (kidney-specific), siRNA knockdown Frontiers in cell and developmental biology Medium 34434929
2016 ING2 acts as a corepressor of the androgen receptor (AR), interacting with AR to inhibit AR-mediated transactivation, induce cell cycle arrest and cellular senescence, and upregulate p16INK4a; ING2 protein levels are increased as a compensatory mechanism when ING1 is deficient. Co-immunoprecipitation, siRNA knockdown, luciferase reporter assay, Ing1 knockout mouse Journal of molecular medicine (Berlin, Germany) Medium 27305909
2021 ING1 and ING2 are recruited to the hTERT core promoter in an androgen-dependent manner and mediate AR-driven transcriptional repression of hTERT at supraphysiological androgen levels; knockdown of ING1/ING2 abolishes this repression. Chromatin immunoprecipitation (ChIP), siRNA knockdown, luciferase reporter assay with defined negative androgen response element Cancers Medium 34439179
2007 ING2 directly interacts with the corepressor Alien both in vivo and in vitro (GST pulldown), and expression of ING2 enhances Alien-mediated transcriptional silencing; the Alien binding domain maps to a central region of Alien. SELDI-MS proteomic approach, co-immunoprecipitation, GST pulldown, transcriptional reporter assay Journal of proteome research Low 17929852

Source papers

Stage 0 corpus · 47 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature 750 16728974
2006 Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature 564 16728977
2003 The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell 439 12859901
2001 DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. Proceedings of the National Academy of Sciences of the United States of America 177 11481424
2005 ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. Molecular and cellular biology 110 16024799
2010 Deacetylase inhibitors dissociate the histone-targeting ING2 subunit from the Sin3 complex. Chemistry & biology 65 20142042
2006 The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation. Cancer research 63 16488987
1998 Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor. Cytogenetics and cell genetics 62 10072587
2013 ING1 and ING2: multifaceted tumor suppressor genes. Cellular and molecular life sciences : CMLS 52 23412501
2007 Decreased expression of ING2 gene and its clinicopathological significance in hepatocellular carcinoma. Cancer letters 50 18160212
2010 Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. PloS one 48 21124965
2013 Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage. Scientific reports 47 23823870
2008 ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells. The Journal of biological chemistry 46 18334480
2006 Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis. FEBS letters 46 16782091
2006 Nuclear ING2 expression is reduced in human cutaneous melanomas. British journal of cancer 44 16755297
2009 ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. International journal of cancer 39 19437536
2006 Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer. Oncology reports 36 16465410
2010 HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation. FEBS letters 35 20621832
2004 Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes. Journal of cutaneous pathology 32 15005689
2020 The Role of Petrimonas mucosa ING2-E5AT in Mesophilic Biogas Reactor Systems as Deduced from Multiomics Analyses. Microorganisms 31 33348776
2008 Frequent deletion of ING2 locus at 4q35.1 associates with advanced tumor stage in head and neck squamous cell carcinoma. Journal of cancer research and clinical oncology 31 18998165
2007 Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling. Journal of the American Chemical Society 31 17469822
2004 The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells. Experimental cell research 31 15748897
2009 ING2 controls the progression of DNA replication forks to maintain genome stability. EMBO reports 30 19730436
2010 ING2 controls the G1 to S-phase transition by regulating p21 expression. Cell cycle (Georgetown, Tex.) 25 20890119
2009 Expression of candidate tumor suppressor gene ING2 is lost in non-small cell lung carcinoma. Lung cancer (Amsterdam, Netherlands) 23 19962781
2010 Sumoylation of ING2 regulates the transcription mediated by Sin3A. Oncogene 22 20676127
2012 Identification of a novel function for the chromatin remodeling protein ING2 in muscle differentiation. PloS one 21 22808232
2016 A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling. Journal of molecular medicine (Berlin, Germany) 19 27305909
2021 Antithetic hTERT Regulation by Androgens in Prostate Cancer Cells: hTERT Inhibition Is Mediated by the ING1 and ING2 Tumor Suppressors. Cancers 17 34439179
2008 A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis. FEBS letters 17 18951897
2005 Multiple variants of the ING1 and ING2 tumor suppressors are differentially expressed and thyroid hormone-responsive in Xenopus laevis. General and comparative endocrinology 17 15955533
2018 Cell-free plasma hypermethylated CASZ1, CDH13 and ING2 are promising biomarkers of esophageal cancer. Journal of biomedical research 16 30355852
2008 ING2 recruits histone methyltransferase activity with methylation site specificity distinct from histone H3 lysines 4 and 9. Biochimica et biophysica acta 16 18513492
2022 ING2-WTAP is a potential therapeutic target in non-small cell lung cancer. Biochemical and biophysical research communications 14 35306362
2017 ING2, a tumor associated gene, enhances PAI‑1 and HSPA1A expression with HDAC1 and mSin3A through the PHD domain and C‑terminal. Molecular medicine reports 11 28944862
2014 Complete genome sequence of Peptoniphilus sp. strain ING2-D1G isolated from a mesophilic lab-scale completely stirred tank reactor utilizing maize silage in co-digestion with pig and cattle manure for biomethanation. Journal of biotechnology 10 25242663
2021 ING2 tumor suppressive protein translocates into mitochondria and is involved in cellular metabolism homeostasis. Oncogene 9 34017078
2019 Exploiting ING2 Epigenetic Modulation as a Therapeutic Opportunity for Non-Small Cell Lung Cancer. Cancers 8 31640185
2007 The tumor suppressors p33ING1 and p33ING2 interact with alien in vivo and enhance alien-mediated gene silencing. Journal of proteome research 8 17929852
2015 ING2 (inhibitor of growth protein-2) plays a crucial role in preimplantation development. Zygote (Cambridge, England) 7 25672483
2021 ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells. Frontiers in cell and developmental biology 6 34434929
2014 Nuclear ING2 expression is reduced in osteosarcoma. Oncology reports 6 25190103
2014 Decreased expression of ING2 gene and its clinicopathological significance in Chinese NSCLC patients. Neoplasma 4 24712846
2009 MMR/c-Abl-dependent activation of ING2/p73alpha signaling regulates the cell death response to N-methyl-N'-nitro-N-nitrosoguanidine. Experimental cell research 4 19766113
2007 Multiple ING1 and ING2 genes in Xenopus laevis and evidence for differential association of thyroid hormone receptors and ING proteins to their promoters. Biochimica et biophysica acta 3 18167318
2017 The completely annotated genome and comparative genomics of the Peptoniphilaceae bacterium str. ING2-D1G, a novel acidogenic bacterium isolated from a mesophilic biogas reactor. Journal of biotechnology 2 28595834