Affinage

CNOT7

CCR4-NOT transcription complex subunit 7 · UniProt Q9UIV1

Length
285 aa
Mass
32.7 kDa
Annotated
2026-06-09
26 papers in source corpus 17 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/8 claims corpus-supported (88%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CNOT7 (hCAF1/Caf1a) is a DEDD-domain deadenylase and a catalytic subunit of the CCR4-NOT complex that removes mRNA poly(A) tails to control message stability and translation across diverse physiological programs (PMID:19605561, PMID:31924127). It outcompetes its paralog CNOT8 for the scaffold subunit CNOT1, and CNOT7/CNOT8 deadenylase activity—not the CNOT6/6L deadenylases—is essential for cell viability, since catalytically dead CNOT7 fails to rescue death of Cnot7/8 double-knockout fibroblasts (PMID:31924127, PMID:35248544). CNOT7 serves as the obligate deadenylase effector for the anti-proliferative BTG/TOB proteins, whose suppressive activity requires direct binding to CNOT7 (PMID:23236473), and this CNOT7–TOB1–CNOT1 axis drives post-transcriptional silencing of a metastasis-suppressive program in tumor cells (PMID:26807845). Its catalytic activity executes regulated mRNA turnover in specialized contexts: deadenylation of maternal mRNAs during oocyte meiotic maturation and the maternal-to-zygotic transition (PMID:26134871, PMID:28557307), dynamic poly(A) tail control of dendritic mRNAs underlying learning and memory (PMID:28723570), and TTP-directed decay of inflammatory ARE-containing transcripts such as ICAM-1 and IL-8 (PMID:25038453). In innate immunity CNOT7 sequesters latent STAT1 in the cytoplasm and deadenylates STAT1-regulated mRNAs to extinguish interferon signaling (PMID:23386060). CNOT7 also functions outside RNA decay: it binds the AF-1 domain of RXRβ as a Sertoli-cell coregulator required for spermatogenesis (PMID:15107851, PMID:15700538), antagonizes BMP-induced osteoblast activity via TOB to suppress bone mass (PMID:17451368), and promotes radiation resistance by stabilizing XRCC6 against TRIM21-mediated K48 ubiquitination while deadenylating TRIM21 mRNA (PMID:41249119). An alternatively spliced nuclear isoform, CNOT7v2, lacks deadenylase activity, does not bind BTG proteins, and instead associates with PRMT1 to regulate arginine methylation and alternative splicing (PMID:28591869). Small-molecule active-site inhibitors of CNOT7 have been developed as tools to separate its catalytic from non-catalytic roles (PMID:39339346).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2004 High

    Established the first physiological role for CNOT7 by showing it acts as an RXRβ coregulator in the somatic compartment of the testis, defining a cell-non-autonomous requirement for spermatogenesis.

    Evidence AF-1 domain binding assay, Cnot7 knockout phenotyping, and reciprocal spermatogonial transplantation in mice

    PMID:15107851 PMID:15700538

    Open questions at the time
    • Did not connect the RXRβ coregulator role to deadenylase activity
    • Molecular targets downstream of RXRβ/CNOT7 in Sertoli cells not identified
  2. 2007 High

    Identified CNOT7 as an endogenous suppressor of bone mass that antagonizes BMP-induced osteoblast activity through its interaction with the BMP inhibitor TOB, placing it within BMP signaling.

    Evidence Cnot7 knockout microCT/histomorphometry, in vitro and in vivo BMP stimulation of osteoblasts

    PMID:17451368

    Open questions at the time
    • Whether bone suppression requires deadenylase activity not tested
    • Direct mRNA targets in osteoblasts not defined
  3. 2009 High

    Defined CNOT7 as a DEDD-domain deadenylase required for cell proliferation, partly through its catalytic activity, with partial redundancy with CNOT8.

    Evidence siRNA knockdown of CNOT7/CNOT8 in MCF7 cells with catalytic mutant analysis and expression profiling

    PMID:19605561

    Open questions at the time
    • Catalytic vs non-catalytic contributions only partially separated
    • Specific proliferation-relevant target mRNAs not pinpointed
  4. 2012 High

    Showed BTG/TOB anti-proliferative proteins exert their effect specifically through CNOT7/CNOT8, establishing CNOT7 as the deadenylase effector of BTG/TOB and excluding CCR4 paralogs.

    Evidence Structure-guided mutagenesis of BTG2/TOB1 interaction surfaces with proliferation and mRNA/translation assays

    PMID:23236473

    Open questions at the time
    • mRNA targets selectively regulated by the BTG/TOB-CNOT7 axis not enumerated
  5. 2013 High

    Revealed a dual role for CNOT7 in interferon signaling—cytoplasmic sequestration of latent STAT1 and deadenylation of STAT1-regulated mRNAs—coupling protein trafficking control to mRNA decay during signal extinction.

    Evidence Reciprocal Co-IP for hCAF1-STAT1, siRNA knockdown, promoter occupancy and antiviral protection assays, deadenylase assay

    PMID:23386060

    Open questions at the time
    • Structural basis of STAT1 shielding unknown
    • How IFN triggers STAT1 release from hCAF1 not mechanistically resolved
  6. 2014 Medium

    Positioned CNOT7 as the deadenylase effector downstream of TTP in ARE-mediated decay of inflammatory mRNAs, linking it to TNF-α-responsive gene regulation.

    Evidence Co-IP of TTP-CNOT7-CNOT1 complex, RIP, siRNA knockdown with mRNA stability and protein readouts

    PMID:25038453

    Open questions at the time
    • Single-lab Co-IP without reciprocal validation across systems
    • Breadth of TTP-dependent targets requiring CNOT7 not defined
  7. 2015 High

    Demonstrated that translational up-regulation of CNOT7 from a dormant maternal mRNA is necessary and sufficient to trigger maternal mRNA deadenylation during oocyte maturation, defining CNOT7 abundance as the rate-limiting switch.

    Evidence siRNA knockdown and ectopic expression in mouse oocytes with poly(A) tail and transcription assays

    PMID:26134871

    Open questions at the time
    • Mechanism coupling CNOT7 loss to reduced 2-cell transcription unclear
    • Specificity for particular maternal transcripts not mapped
  8. 2016 High

    Connected CNOT7 deadenylase activity and its CNOT1/TOB1 interactions to tumor-cell-autonomous metastatic potential via post-transcriptional suppression of a metastasis-suppressive program.

    Evidence Orthotopic metastasis and GEMM assays, catalytic-dead rescue, Co-IP, RIP-seq, transcriptome analysis

    PMID:26807845

    Open questions at the time
    • Identity of individual metastasis-suppressive effector transcripts not fully resolved
    • RNA-binding proteins reading the tripartite 3'UTR motif not all defined
  9. 2017 High

    Showed CNOT7 dynamically tunes dendritic mRNA poly(A) tail length in response to synaptic stimulation and is required for hippocampal learning and memory, extending its deadenylase role to neuronal plasticity.

    Evidence Live imaging, fractionation and poly(A) assays in hippocampal neurons, knockdown, in vivo behavioral testing

    PMID:28723570

    Open questions at the time
    • Signaling that drives rapid CNOT7 loss after stimulation unknown
    • Specific synaptic mRNA targets not comprehensively identified
  10. 2017 High

    Characterized a nuclear, catalytically inactive splice isoform (CNOT7v2) that associates with PRMT1 and regulates arginine methylation and alternative splicing, revealing a deadenylase-independent function.

    Evidence Splice-variant biochemistry, fractionation, in vitro deadenylase assay, PRMT1 Co-IP, splicing reporter assays

    PMID:28591869

    Open questions at the time
    • In vivo significance of CNOT7v2 not established
    • How v2 modulates PRMT1 activity mechanistically unclear
  11. 2017 Medium

    Placed Cnot7-mediated deadenylation alongside Dcp2 decapping as pervasive but non-uniform contributors to maternal mRNA clearance during the maternal-to-zygotic transition.

    Evidence RNA-seq comparison of Cnot7-depleted and catalytically inactive Dcp2 zebrafish embryos

    PMID:28557307

    Open questions at the time
    • Determinants of transcript-specific pathway preference not defined
    • Single-organism, single-lab analysis
  12. 2020 High

    Established that CNOT7/CNOT8 deadenylase activity is essential for cell viability and that CNOT6/6L cannot substitute, formally ranking the two deadenylase pairs within the CCR4-NOT complex.

    Evidence Cnot7/8 and Cnot6/6l double-knockout MEFs with catalytic-dead rescue, Co-IP, poly(A) and mRNA stability profiling

    PMID:31924127

    Open questions at the time
    • Essential target mRNAs whose dysregulation causes death not identified
  13. 2022 High

    Explained CNOT7 dominance over CNOT8 by showing it has higher affinity for the CNOT1 scaffold and blocks CNOT8 incorporation, with CNOT8 stabilized only when CNOT7 is depleted.

    Evidence Reciprocal Co-IP competition, knockdown, protein and mRNA stability and translation assays

    PMID:35248544

    Open questions at the time
    • Structural basis of differential CNOT1 affinity not resolved
    • Functional consequence of CNOT8 substitution on target repertoire unclear
  14. 2025 High

    Defined a non-canonical role in DNA repair whereby CNOT7 stabilizes XRCC6 by blocking TRIM21-mediated K48 ubiquitination and deadenylates TRIM21 mRNA, promoting NHEJ and radiation resistance in colorectal cancer.

    Evidence Co-IP, ubiquitination site mapping at K526, knockdown in vitro and in xenograft/PDX models, TRIM21 mRNA stability and DSB repair assays

    PMID:41249119

    Open questions at the time
    • How CNOT7 sterically or enzymatically blocks TRIM21 ubiquitination unclear
    • Generality beyond colorectal cancer untested
  15. 2024 Medium

    Provided first chemical inhibitors of the CNOT7 nuclease active site with a defined predicted binding mode, enabling pharmacological dissection of catalytic function.

    Evidence Fluorescence nuclease IC50 assay, SAR of 16 analogues, molecular docking

    PMID:39339346

    Open questions at the time
    • No crystal structure confirming docked binding mode
    • Cellular potency and selectivity not demonstrated
  16. 2025 Low

    Expanded the inhibitor toolkit through high-throughput screening, yielding multiple sub-25 μM CNOT7 nuclease inhibitors to differentiate catalytic from non-catalytic roles.

    Evidence Fluorescence biochemical nuclease screen of 10,880 compounds with docking

    PMID:41301481

    Open questions at the time
    • No structural validation or cellular mechanistic follow-up
    • Selectivity over CNOT8/CNOT6 not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • How CNOT7 substrate selectivity, recruitment by distinct RNA-binding adaptors, and its catalytic versus scaffolding/protein-stabilizing functions are coordinated across its many physiological contexts remains unresolved.
  • No unifying determinant of context-specific target choice identified
  • Structural basis for adaptor (BTG/TOB, TTP, STAT1, XRCC6) discrimination unknown
  • Relative in vivo importance of catalytic vs non-catalytic roles not quantified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140098 catalytic activity, acting on RNA 4 GO:0016787 hydrolase activity 2 GO:0098772 molecular function regulator activity 2 GO:0003723 RNA binding 1 GO:0140110 transcription regulator activity 1
Localization
GO:0005829 cytosol 3 GO:0005634 nucleus 1
Pathway
R-HSA-8953854 Metabolism of RNA 3 R-HSA-1474165 Reproduction 2 R-HSA-162582 Signal Transduction 2 R-HSA-1643685 Disease 2 R-HSA-168256 Immune System 2 R-HSA-73894 DNA Repair 1
Partners
BTG2CNOT1CNOT8PRMT1RXRBSTAT1TOB1XRCC6
Complex memberships
CCR4-NOT

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 CNOT7 binds the AF-1 domain of retinoid X receptor beta (RXRβ) and functions as a coregulator of RXRβ in testicular somatic cells (Sertoli cells); loss of CNOT7 impairs RXRβ function and leads to oligo-astheno-teratozoospermia. Spermatogonial transplantation demonstrated the defect is in the somatic (Sertoli cell) microenvironment, not the germ cells. Co-immunoprecipitation/binding assay for AF-1 domain interaction; spermatogonial stem cell transplantation epistasis; Cnot7 knockout mouse phenotypic analysis Nature genetics High 15107851 15700538
2004 Wild-type germ cells transplanted into Cnot7−/− testes develop abnormal spermatids, confirming that Sertoli cell defects (not germ cell-intrinsic defects) are responsible for the spermatogenic failure in Cnot7-null mice. Reciprocal spermatogonial transplantation assay Archives of histology and cytology High 15700538
2007 CNOT7 acts as an endogenous suppressor of bone mass by inhibiting BMP-induced osteoblast activity; Cnot7−/− mice show >50% increase in bone mass with enhanced bone formation but no change in resorption, and Cnot7−/− osteoblasts exhibit heightened BMP-induced alkaline phosphatase expression. CNOT7 binds TOB, a BMP inhibitor, placing it in the BMP signaling pathway in osteoblasts. Cnot7 knockout mouse histomorphometry, microCT, in vitro BMP stimulation of calvaria-derived osteoblasts, in vivo BMP2 injection assay, TOB interaction (binding data from prior work cited) Journal of bone and mineral research High 17451368
2009 Human CNOT7 (hCaf1/Caf1a) and its paralog CNOT8 possess deadenylase activity mediated by DEDD nuclease domains and are required for efficient cell proliferation; CNOT7's role in proliferation partly depends on its catalytic activity. Combined knockdown of CNOT7 and CNOT8 further reduces proliferation, indicating partial functional redundancy. siRNA knockdown of CNOT7 and/or CNOT8 in MCF7 cells; cell proliferation assays; gene expression profiling; catalytic mutant analysis Molecular biology of the cell High 19605561
2012 The anti-proliferative activity of BTG/TOB proteins (BTG2, TOB1) requires direct interaction with CNOT7 (Caf1a) and CNOT8 (Caf1b) deadenylases; BTG/TOB mutants unable to bind Caf1a/Caf1b lose anti-proliferative activity. BTG/TOB regulation of mRNA abundance and translation also depends on Caf1a/Caf1b, and does not require the Ccr4a/Ccr4b deadenylases or non-catalytic subunits CNOT1/CNOT3. Structure-guided mutagenesis of BTG2/TOB1 interaction surfaces; cell proliferation assays with interaction-deficient mutants; mRNA abundance and translation assays PloS one High 23236473
2013 CNOT7/hCAF1 regulates interferon (IFN) signaling by: (1) interacting with latent STAT1 in the cytoplasm of resting cells to control STAT1 trafficking/shielding from undesirable stimulation; (2) upon IFN treatment, STAT1 is released from hCAF1; (3) hCAF1 silencing enhances basal STAT1 promoter occupancy and expression of STAT1-regulated genes, conferring increased antiviral protection; (4) hCAF1 uses its deadenylase activity to accelerate degradation of STAT1-regulated mRNAs during IFN signal extinction. Co-immunoprecipitation (hCAF1–STAT1 interaction); hCAF1 siRNA knockdown; reporter/promoter occupancy assays; viral infection protection assays; deadenylase activity assay The EMBO journal High 23386060
2014 CNOT7/hCAF1, tristetraprolin (TTP), and CNOT1 form a co-immunoprecipitable complex; CNOT7 silencing stabilizes ICAM-1 and IL-8 mRNAs and increases their protein levels after TNF-α stimulation, establishing CNOT7 as the deadenylase effector downstream of TTP-ARE-mediated mRNA decay for these inflammatory targets. Co-immunoprecipitation (TTP–CNOT7–CNOT1 complex); RIP (TTP bound to ICAM-1 and IL-8 mRNAs); siRNA knockdown of CNOT7; mRNA stability and protein quantification Cellular signalling Medium 25038453
2015 CNOT7 is encoded by a dormant maternal mRNA in mouse oocytes that is recruited (translated) during meiotic maturation; the resulting increase in CNOT7 protein is necessary and sufficient to drive deadenylation of maternal mRNAs. Inhibiting the maturation-associated increase in CNOT7 via siRNA blocks mRNA deadenylation, whereas premature expression of CNOT7 in pre-maturation oocytes initiates deadenylation. Loss of the CNOT7 increase also causes ~70% decrease in transcription in 2-cell embryos. siRNA knockdown of CNOT7 during oocyte maturation; ectopic CNOT7 expression in meiotically arrested oocytes; poly(A) tail length assays; quantification of total poly(A); transcription assay in 2-cell embryos Biology of reproduction High 26134871
2016 CNOT7 drives tumor cell-autonomous metastatic potential in a manner requiring its deadenylase activity and its interactions with CNOT1 and TOB1. CNOT7 RIP identified target transcripts enriched for a tripartite 3'UTR motif bound by RNA-binding proteins known to complex with CNOT7/TOB1/CNOT1, supporting a model of post-transcriptional suppression of a metastasis-suppressive transcriptional program. Orthotopic metastasis assays; genetically engineered mouse models; deadenylase-dead mutant rescue; co-immunoprecipitation for CNOT1 and TOB1 interactions; RIP-seq; transcriptome analysis PLoS genetics High 26807845
2017 CNOT7 dynamically regulates dendritic mRNA poly(A) tail length and transport in hippocampal neurons; synaptic stimulation causes a rapid decrease in CNOT7, leading to transient poly(A) elongation of target mRNAs, followed by later deadenylation. CNOT7 is required for hippocampal-dependent learning and memory in mice. Live imaging and fractionation of CNOT7 in cultured hippocampal neurons; poly(A) tail length assays after synaptic stimulation; CNOT7 knockdown; in vivo behavioral/cognitive testing in mice Cell reports High 28723570
2017 Alternative splicing of the CNOT7 gene produces a shorter isoform (CNOT7v2) that: (1) interacts with CCR4-NOT subunits but not BTG proteins; (2) localizes to the nucleus rather than cytoplasm; (3) lacks poly(A)-degrading activity in vitro despite conserved DEDD domain; (4) preferentially associates with PRMT1 to regulate its arginine methyltransferase activity; and (5) regulates inclusion of CD44 variable exons (alternative splicing). Biochemical characterization of splice variant; subcellular fractionation/localization; in vitro deadenylase assay; co-immunoprecipitation with PRMT1; alternative splicing reporter assays in cellulo Nucleic acids research High 28591869
2017 In zebrafish, Cnot7-mediated deadenylation and Dcp2-mediated decapping make pervasive but nonuniform contributions to maternal mRNA clearance during maternal-to-zygotic transition; individual mRNAs differ in their relative dependency on each pathway. Overexpression of catalytically inactive Dcp2; RNA-seq to measure mRNA levels; comparison with Cnot7-depleted embryos Genes to cells Medium 28557307
2020 CNOT7 and CNOT8 together are essential for cell viability in primary mouse embryonic fibroblasts (MEFs): Cnot7/8 double-KO MEFs undergo cell death, whereas Cnot6/6l double-KO MEFs remain viable. Exogenous catalytically dead CNOT7 cannot rescue viability, establishing that CNOT7/8 deadenylase activity is essential. In Cnot7/8-dKO MEFs, CNOT6/6L are also absent from the CCR4-NOT complex (detected by Co-IP), but CNOT6/6L alone are insufficient for cell viability. Double-knockout MEFs (Cnot7/8 and Cnot6/6l); catalytic mutant rescue experiment; co-immunoprecipitation to assess complex assembly; bulk poly(A) tail analysis; mRNA stability profiling RNA biology High 31924127
2022 CNOT7 outcompetes its paralog CNOT8 for incorporation into the CCR4-NOT complex: CNOT7 has greater affinity for the scaffold protein CNOT1 and can block CNOT8 from binding CNOT1. Depletion of CNOT7 increases CNOT8 incorporation into the CCR4-NOT complex and stabilizes CNOT8 protein. CNOT8 protein is less stable than CNOT7, and its increased abundance upon CNOT7 depletion is not due to mRNA stabilization or increased translation. Co-immunoprecipitation (CNOT7/CNOT8 competition for CNOT1); siRNA knockdown; protein stability assays; mRNA quantification; polysome/translation analysis Journal of molecular biology High 35248544
2024 Small-molecule inhibitors of the CNOT7/Caf1 nuclease active site were identified; molecular docking suggests binding involves π-π interactions with His225, hydrogen bonding with the backbone of Phe43, and Van der Waals interactions with His225, Leu209, Leu112, and Leu115. Substituents on the 1-phenyl group of the inhibitor scaffold contribute significantly to binding potency. Fluorescence-based nuclease assay (biochemical IC50 determination); structure–activity relationship analysis of 16 analogues; molecular docking to active site Molecules Medium 39339346
2025 CNOT7 promotes radiation resistance in colorectal cancer by stabilizing XRCC6 protein: CNOT7 interacts with XRCC6 and inhibits TRIM21-mediated K48-linked ubiquitination at lysine 526 of XRCC6, preventing its proteasomal degradation and facilitating NHEJ-mediated DNA double-strand break repair. Additionally, CNOT7 uses its deadenylase activity to accelerate TRIM21 mRNA degradation, reducing TRIM21 levels. Co-immunoprecipitation (CNOT7–XRCC6 interaction); ubiquitination assay (K48-linkage at K526); CNOT7 KD in vitro and in vivo (xenograft); mRNA stability assay for TRIM21; DSB repair assays; PDX tumor models Cell death & disease High 41249119
2025 High-throughput screening of 10,880 compounds identified 15 small-molecule inhibitors of CNOT7/Caf1 poly(A)-selective nuclease activity with IC50 values below 25 μM, providing chemical tools to differentiate catalytic from non-catalytic roles of CNOT7. Fluorescence-based biochemical nuclease assay screen; molecular docking for binding mode prediction Biomolecules Low 41301481

Source papers

Stage 0 corpus · 26 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta. Nature genetics 108 15107851
2009 The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation. Molecular biology of the cell 97 19605561
2012 The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. PloS one 64 23236473
2015 Mobilization of Dormant Cnot7 mRNA Promotes Deadenylation of Maternal Transcripts During Mouse Oocyte Maturation. Biology of reproduction 58 26134871
2016 Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7. PLoS genetics 38 26807845
2020 Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. RNA biology 37 31924127
2022 Methylation recognition protein YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) regulates the proliferation, migration and invasion of osteosarcoma by regulating m6A level of CCR4-NOT transcription complex subunit 7 (CNOT7). Bioengineered 28 35156522
2013 hCAF1/CNOT7 regulates interferon signalling by targeting STAT1. The EMBO journal 28 23386060
2007 Cnot7-null mice exhibit high bone mass phenotype and modulation of BMP actions. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 27 17451368
2020 MicroRNA-126-5p Inhibits the Migration of Breast Cancer Cells by Directly Targeting CNOT7. Technology in cancer research & treatment 19 33256566
2004 Abnormal sperm morphology caused by defects in Sertoli cells of Cnot7 knockout mice. Archives of histology and cytology 17 15700538
2017 Dynamic Control of Dendritic mRNA Expression by CNOT7 Regulates Synaptic Efficacy and Higher Cognitive Function. Cell reports 15 28723570
2014 CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by tristetraprolin. Cellular signalling 14 25038453
2003 Analysis of the transcription regulator, CNOT7, as a candidate chromosome 8 tumor suppressor gene in colorectal cancer. International journal of cancer 12 12845644
2017 Alternative splicing of CNOT7 diversifies CCR4-NOT functions. Nucleic acids research 11 28591869
2022 CNOT7 Outcompetes Its Paralog CNOT8 for Integration into The CCR4-NOT Complex. Journal of molecular biology 10 35248544
2021 CNOT7 modulates biological functions of ovarian cancer cells via AKT signaling pathway. Life sciences 10 33412213
2020 CNOT7 depletion reverses natural killer cell resistance by modulating the tumor immune microenvironment of hepatocellular carcinoma. FEBS open bio 10 32160402
2017 Pervasive yet nonuniform contributions of Dcp2 and Cnot7 to maternal mRNA clearance in zebrafish. Genes to cells : devoted to molecular & cellular mechanisms 9 28557307
2023 CCR4-NOT subunit CCF-1/CNOT7 promotes transcriptional activation to multiple stress responses in Caenorhabditis elegans. Aging cell 8 36797658
2006 Expression analysis of LacZ gene placed in the locus of Cnot7 exhibits its activity in osteoblasts in vivo and in mineralized nodules in vitro. Journal of cellular biochemistry 5 16639713
2024 CNOT7 regulates lipid deposition in nonalcoholic fatty liver disease. Biochemical and biophysical research communications 2 38772212
2025 CCR4-NOT Transcription Complex Subunit 7 (CNOT7) Protein and Leukocyte-Associated Immunoglobulin-like Receptor-1 in Breast Cancer Progression: Clinical Mechanistic Insights and In Silico Therapeutic Potential. International journal of molecular sciences 1 40806280
2024 Discovery of Substituted 5-(2-Hydroxybenzoyl)-2-Pyridone Analogues as Inhibitors of the Human Caf1/CNOT7 Ribonuclease. Molecules (Basel, Switzerland) 1 39339346
2025 CNOT7 facilitates radiation resistance in colorectal cancer through TRIM21/XRCC6-mediated non-homologous end joining repair. Cell death & disease 0 41249119
2025 Discovery of Drug-like Inhibitors of the Human Caf1/CNOT7 poly(A)-Selective Nuclease Using Compound Screening. Biomolecules 0 41301481

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