Affinage

CNOT6

CCR4-NOT transcription complex subunit 6 · UniProt Q9ULM6

Length
557 aa
Mass
63.3 kDa
Annotated
2026-06-09
46 papers in source corpus 19 papers cited in narrative 19 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CNOT6 (CCR4a) is an EEP-domain exonuclease subunit of the conserved CCR4-NOT deadenylase complex that shortens mRNA poly(A) tails to drive substrate-selective decay (PMID:31320642, PMID:31924127). It is scaffolded into the complex through the NOT1 MIF4G domain, which bridges the catalytic module while leaving the nuclease active sites accessible to RNA (PMID:22977175), and its incorporation depends on CNOT7/8 (CAF1) — loss of CNOT7/8 removes CNOT6/6L from the complex, whereas loss of CNOT6/6L leaves CNOT7/8 bound to other subunits (PMID:31924127), a dependency that can be exploited by the Legionella effector PieF, which displaces CNOT6/6L by binding CNOT7 (PMID:39699231). Within the reconstituted complex CNOT6 and CAF1 have distinct, cooperative deadenylation profiles, with both nuclease activities required and non-catalytic modules (CAF40, NOT10:NOT11) stimulating activity (PMID:31320642, PMID:25944446). Functionally CNOT6 (acting with its paralog CNOT6L) executes targeted decay of specific transcripts: it regulates IGFBP5 and p21 mRNAs to control cell-cycle arrest and senescence (PMID:21233283, PMID:33671234), is recruited by the RNA-binding protein ENO1 to degrade IRP1 mRNA and suppress ferroptosis, an interaction governed by ENO1 lactylation state (PMID:35121990, PMID:41532698), regulates DNA mismatch-repair gene transcripts to modulate genome stability and drug sensitivity (PMID:35159331, PMID:18818012), and directs developmental and endocrine programs including oocyte meiotic maturation, gonadotropin-driven granulosa-cell transcript clearance and female fertility (PMID:29717177, PMID:34788619). Its own expression is controlled post-transcriptionally by PCIF1-dependent m6A modification of CNOT6 mRNA (PMID:39451207). CNOT6 also potentiates nuclear hormone receptor transcription through an NIF-1-dependent mechanism acting on the receptor ligand-binding domain (PMID:18180299).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2008 Medium

    Established a non-deadenylase role: CNOT6 was shown to potentiate nuclear hormone receptor transcription, indicating functions beyond mRNA turnover.

    Evidence siRNA knockdown, reciprocal Co-IP and reporter/qPCR of RARα targets in human cells

    PMID:18180299

    Open questions at the time
    • Mechanism linking a cytoplasmic deadenylase to nuclear receptor transcription unresolved
    • NIF-1 dependency not structurally defined
  2. 2008 Medium

    Linked CNOT6 to the DNA-damage response, showing its expression level modulates cellular sensitivity to genotoxic agents.

    Evidence GSE selection, siRNA/overexpression with Chk2 and γH2AX Western blots after cisplatin

    PMID:18818012

    Open questions at the time
    • Direct mRNA targets mediating Chk2 effect not identified
    • Single study, single cell context
  3. 2011 Medium

    Distinguished CNOT6/6L from the CAF1 nucleases functionally, tying them to IGFBP5 mRNA decay and a p53-dependent senescence program.

    Evidence siRNA knockdown with senescence, cell-cycle, P-body and expression-profiling readouts in human cells

    PMID:21233283

    Open questions at the time
    • Direct vs indirect targeting of IGFBP5 not fully resolved
    • LRR-localization link is for the paralog CNOT6L
  4. 2012 High

    Defined how the CNOT6/CAF1 catalytic module is assembled into CCR4-NOT, answering how the nuclease is positioned within the complex.

    Evidence X-ray crystallography of NOT1 MIF4G apo and CAF1-bound forms with interface mutagenesis

    PMID:22977175

    Open questions at the time
    • Structure does not capture CNOT6 directly bound
    • Full-complex architecture not resolved
  5. 2015 High

    Demonstrated catalytic cooperation: both CNOT6 (Ccr4) and CAF1 enzymatic activities are required for deadenylation within a minimal module.

    Evidence In vitro deadenylation with purified BTG2-CAF1-CCR4 sub-complex, active-site mutagenesis and chemical inhibition

    PMID:25944446

    Open questions at the time
    • Allosteric regulation mechanism inferred, not structurally shown
    • Substrate-specific division of labor unclear
  6. 2019 High

    Resolved distinct enzymatic profiles of CNOT6 versus CAF1 and the stimulatory role of non-catalytic modules in a fully reconstituted human complex.

    Evidence In vitro reconstitution of recombinant human CCR4-NOT with compositional control and deadenylation assays

    PMID:31320642

    Open questions at the time
    • In-cell substrate selectivity not addressed
    • Regulatory inputs determining CNOT6 vs CAF1 usage unknown
  7. 2019 Medium

    Showed that CNOT6-driven changes in mRNA stability are buffered by compensatory transcription, explaining why decay activity does not always alter steady-state abundance.

    Evidence siRNA knockdown with paired mRNA stability and transcription-rate measurements in HepG2 cells

    PMID:31116665

    Open questions at the time
    • Sensing mechanism coupling decay to transcription not defined
    • Single cell line
  8. 2020 High

    Established the hierarchy of subunit essentiality, showing CNOT6/6L are dispensable for viability while their complex incorporation requires CNOT7/8.

    Evidence CRISPR double knockouts in MEFs and mice, Co-IP, and bulk poly(A) profiling

    PMID:31924127

    Open questions at the time
    • Specific transcripts uniquely dependent on CNOT6/6L not enumerated
    • Tissue-specific essential roles not probed here
  9. 2021 High

    Defined an in vivo physiological requirement: CNOT6/6L act as FSH effectors essential for female reproductive endocrine regulation.

    Evidence Constitutive/conditional knockout mice, gonadotropin stimulation, transcriptome analysis and fertility phenotyping

    PMID:34788619

    Open questions at the time
    • Direct FSH-induced decay targets not fully mapped
    • Relative contributions of CNOT6 vs CNOT6L not separated
  10. 2021 Medium

    Identified CNOT6 as a recruited effector of sequence-specific decay, linking the RNA-binding protein ENO1 to IRP1 mRNA degradation and ferroptosis suppression.

    Evidence Co-IP, RIP, knockdown and in vitro/in vivo functional assays in hepatocellular carcinoma

    PMID:35121990

    Open questions at the time
    • Whether ENO1 recruits the full complex or CNOT6 alone unclear
    • Generality of ENO1-CNOT6 axis beyond HCC unknown
  11. 2021 Medium

    Extended target-specific decay to cell-cycle control, identifying p21 mRNA as a CNOT6/6L (but not CAF1) substrate.

    Evidence shRNA knockdown with cell-cycle analysis, P-body imaging and mRNA stability assays in gastric cancer cells

    PMID:33671234

    Open questions at the time
    • Mechanism of target selectivity over CAF1 unknown
    • Single cancer cell line
  12. 2022 Medium

    Connected CNOT6 to genome maintenance, showing it limits mismatch-repair capacity by destabilizing MMR gene mRNAs.

    Evidence siRNA knockdown with survival, mRNA stability, mutation frequency and MMR reporter assays in U2OS cells

    PMID:35159331

    Open questions at the time
    • Direct vs indirect targeting of MMR transcripts not established
    • Single cell context
  13. 2024 Medium

    Mechanistically defined CNOT6's dependency on CNOT7 through a bacterial effector that displaces it from the complex.

    Evidence Co-IP, in vitro binding/inhibition, yeast genetics and mammalian overexpression with Legionella PieF

    PMID:39699231

    Open questions at the time
    • Physiological consequences of PieF-mediated displacement during infection not detailed
  14. 2024 Medium

    Revealed upstream control of CNOT6 itself, showing PCIF1-dependent m6A modification destabilizes CNOT6 mRNA.

    Evidence siRNA knockdown, MeRIP-qPCR and rescue with a methyltransferase-dead PCIF1 mutant

    PMID:39451207

    Open questions at the time
    • m6A reader mediating CNOT6 decay not identified
    • Functional output of altered CNOT6 dosage not measured
  15. 2025 Medium

    Showed the ENO1-CNOT6 decay axis is switchable by ENO1 lactylation, providing a metabolic control point for transcript stability.

    Evidence Co-IP, RIP, PTM mass spectrometry and RT-qPCR in sepsis endothelial cells (TRIM21 mRNA)

    PMID:41532698

    Open questions at the time
    • Generality of lactylation-controlled CNOT6 recruitment unknown
    • Quantitative contribution to TRIM21 stability not isolated
  16. 2026 Medium

    Distinguished CNOT6 from its paralog as a non-redundant regulator of neonatal growth via hepatic Fgf21 mRNA decay.

    Evidence Cnot6 knockout mouse, hepatic transcriptomics, mRNA stability and metabolic phenotyping (preprint)

    PMID:41757057

    Open questions at the time
    • Preprint, not yet peer-reviewed
    • Direct binding of CNOT6 to Fgf21 mRNA not shown
    • Basis of CNOT6 vs CNOT6L specificity unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • The molecular basis by which CNOT6 selects specific substrates — versus the paralog CNOT6L or the CAF1 nucleases — and how diverse RNA-binding adaptors (ENO1, PUF/PBE factors) recruit it to particular transcripts remains undefined.
  • No structural model of CNOT6 substrate engagement
  • Determinants of CNOT6 vs CNOT6L target specificity unknown
  • Rules governing adaptor-mediated recruitment not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140098 catalytic activity, acting on RNA 3 GO:0003723 RNA binding 2 GO:0016787 hydrolase activity 2
Localization
GO:0005829 cytosol 2
Pathway
R-HSA-1474165 Reproduction 2 R-HSA-1640170 Cell Cycle 2 R-HSA-8953854 Metabolism of RNA 2
Partners
CNOT1CNOT6LCNOT7CNOT8ENO1NIF-1
Complex memberships
CCR4-NOT complex

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2012 Crystal structure of the CAF1-binding (MIF4G) domain of human NOT1 alone and in complex with CAF1 was solved, revealing that NOT1 bridges the interaction between the catalytic module (CAF1/CCR4) and the NOT module, acting as a scaffold for CCR4-NOT complex assembly. The NOT1 MIF4G domain binds CAF1 through a pre-formed interface while leaving the CAF1 catalytic site fully accessible to RNA substrates. X-ray crystallography with functional validation of interface residues Nucleic acids research High 22977175
2019 Reconstitution of a complete recombinant human CCR4-NOT complex showed that CCR4a (CNOT6) and CAF1 have distinct deadenylation profiles in vitro, and that the complex is more active and selective for poly(A) than the isolated exonucleases alone. Non-enzymatic modules (CAF40 and NOT10:NOT11) stimulate deadenylation in a partially redundant manner. In vitro reconstitution of recombinant human CCR4-NOT complex; biochemical deadenylation assay with purified component variants Nature communications High 31320642
2015 Using a purified minimal human BTG2-Caf1-Ccr4 (CNOT6) nuclease sub-complex reconstituted from bacteria, chemical inhibition and inactivating amino acid substitutions demonstrated that both the Caf1 and Ccr4 (CNOT6) enzyme activities are required for deadenylation in vitro, indicating they cooperate and may regulate each other allosterically within the nuclease module. In vitro deadenylation assay with purified recombinant sub-complex; active-site mutagenesis; chemical inhibition The Biochemical journal High 25944446
2011 Knockdown of Ccr4a (CNOT6) and Ccr4b (CNOT6L) in human cells plays a role in cell survival and prevention of senescence, distinct from knockdown of Caf1a/Caf1b or non-catalytic subunits. CNOT6/6L knockdown differentially affects processing-body formation. CNOT6/6L regulate IGFBP5 mRNA, mediating cell cycle arrest and senescence via a p53-dependent pathway. The LRR domain of Ccr4b influences subcellular localization but is not required for deadenylase activity. siRNA knockdown with cell viability, senescence (SA-β-gal), cell cycle, and P-body formation readouts; gene expression profiling; subcellular localization studies Molecular biology of the cell Medium 21233283
2020 In mouse embryonic fibroblasts (MEFs), CNOT6/6L double knockout (dKO) cells remain viable whereas CNOT7/8 dKO cells undergo cell death, demonstrating that CNOT7/8 are the essential deadenylase subunits for cell viability. In Cnot7/8-dKO MEFs, CNOT6/6L are also absent from the CCR4-NOT complex, whereas in Cnot6/6l-dKO MEFs, CNOT7/8 still interacts with other subunits. Bulk poly(A) tail analysis showed more mRNAs with longer poly(A) tails in Cnot7/8-dKO than Cnot6/6l-dKO MEFs. Cnot6/6l-dKO mice are viable and grow normally. CRISPR/genetic double knockout of Cnot6/6l in MEFs and mice; co-immunoprecipitation; bulk poly(A) tail analysis; mRNA stability measurement RNA biology High 31924127
2008 CCR4 (CNOT6) potentiates nuclear hormone receptor transcriptional activity and mediates its effect through the ligand binding domain of nuclear receptors. siRNA knockdown of CCR4 decreased nuclear receptor activation and attenuated stimulation of RARα target genes Sox9 and HoxA1. CCR4 associates in vivo with NIF-1, and the CCR4-enhanced transcriptional activation is dependent on NIF-1. siRNA knockdown; co-immunoprecipitation (in vivo and in vitro); quantitative PCR of target genes; reporter assays The Journal of biological chemistry Medium 18180299
2008 Expression of a GSE fragment of hCCR4/CNOT6 or siRNA knockdown of CNOT6 decreased sensitivity of mammalian cells to DNA-damaging agents (cisplatin). Overexpression of hCCR4 targeted Chk2 following cisplatin exposure without interfering with the upstream ATM/ATR pathway, while strongly increasing γH2AX phosphorylation. Genetic suppressor element (GSE) selection; siRNA knockdown; Western blot for DNA damage response proteins (Chk2, γH2AX) Cancer letters Medium 18818012
2021 ENO1 acts as an RNA-binding protein that recruits CNOT6 to accelerate mRNA decay of IRP1 in hepatocellular carcinoma cells, thereby suppressing mitochondrial iron-induced ferroptosis. This establishes CNOT6 as a downstream effector of an ENO1-dependent mRNA decay pathway. Co-immunoprecipitation; RNA immunoprecipitation; siRNA knockdown; in vitro and in vivo functional assays Nature cancer Medium 35121990
2018 CNOT6 is present in cortical foci of mouse oocytes and regulates a novel pattern of mRNA deadenylation during oocyte meiotic maturation, specifically targeting a subset of mRNAs that are deadenylated in growing oocytes, polyadenylated during early maturation, and then re-deadenylated during late maturation. PUF-binding elements (PBEs) regulate this deadenylation in mature oocytes. Immunofluorescence localization; poly(A) tail length assay; functional perturbation experiments in oocytes Scientific reports Medium 29717177
2021 FSH stimulates transcription and translation of CNOT6 and CNOT6L in ovarian granulosa cells. CNOT6/6L function as key effectors of FSH, triggering clearance of specific transcripts during preantral-to-antral follicle transition. Cnot6l-/- female mice are infertile with poor ovarian responses to gonadotropins. Cnot6/6l double knockout mice demonstrate that CNOT6/6L-mediated mRNA deadenylation is dispensable in most somatic cell types but essential for female reproductive endocrine regulation. Conditional and constitutive knockout mouse models; transcriptome analysis; gonadotropin stimulation assays; fertility phenotyping Cell reports High 34788619
2014 In sea urchin primordial germ cells, Nanos targets CNOT6 mRNA for degradation, creating a stable mRNA environment. Misexpression of CNOT6 in PGCs caused failure to retain Seawi transcripts and Vasa protein. Broad knockdown of CNOT6 expanded the domain of Seawi RNA and exogenous reporters, establishing spatially restricted CNOT6 expression as a mechanism for selective germline RNA localization. mRNA misexpression; morpholino-based knockdown; in situ hybridization; reporter assays in sea urchin embryos Development (Cambridge, England) Medium 25100654
2022 Depletion of CNOT6 sensitizes human U2OS cells to the DNA-damaging agent MNNG, upregulates MMR pathway activity, decreases mutation frequency in MMR-proficient cells, and increases mRNA stability of MMR gene transcripts leading to increased MMR protein expression. This identifies CNOT6 as a novel regulator of DNA mismatch repair via mRNA decay of MMR gene transcripts. siRNA knockdown; cell survival assay; mRNA stability measurement; MMR reporter assay; Western blot Cells Medium 35159331
2021 CNOT6/6L-mediated deadenylation targets p21 mRNA (but not Caf1a/b) in gastric cancer MKN28 cells, contributing to cell cycle regulation. Depletion of CNOT6/6L arrests cells at the G0/G1 phase and modulates CDK-cyclin inhibitor levels without affecting CDKs or cyclins directly. Depletion of CNOT6/6L also impairs processing-body formation. Stable shRNA knockdown; cell cycle analysis; Western blot; P-body imaging; mRNA stability assay Cancers Medium 33671234
2016 Forced expression of a combination of Cnot6, Cnot6l, Cnot7, and Cnot8 increases the number of alkaline phosphatase-positive colonies after iPSC induction and decreases expression of Eomes and p21 mRNAs (which have longer poly(A) tails when Cnot1 is depleted), implicating CCR4-NOT deadenylase activity including CNOT6 in iPSC reprogramming via poly(A) tail regulation of specific mRNAs. Overexpression of deadenylase subunits in MEFs with iPSC induction; alkaline phosphatase assay; poly(A) tail length analysis; qRT-PCR Biochemical and biophysical research communications Low 27037025
2019 CNOT6 knockdown in human HepG2 cells led to significant alteration in stability of specific mRNAs; alterations in half-life were inversely associated with transcription rates, mostly not resulting in changes in mRNA abundance. This demonstrates a buffering mechanism whereby transcript stabilization upon CNOT6 depletion is compensated by decreased transcription. siRNA knockdown; mRNA stability measurement; transcription rate measurement in human cells RNA biology Medium 31116665
2024 The Legionella pneumophila effector PieF disrupts the association between CNOT6/6L EEP-type nucleases and CNOT7, demonstrating that PieF binding to CNOT7 is sufficient to displace CNOT6/6L from the complex. This mechanistically defines a protein-protein interaction dependency of CNOT6/6L on CNOT7 for complex incorporation. Co-immunoprecipitation; in vitro binding/inhibition assay; yeast genetic assay; mammalian cell overexpression mSphere Medium 39699231
2024 PCIF1 negatively regulates CNOT6 mRNA stability through m6A modification: siRNA-mediated suppression of PCIF1 upregulates CNOT6 at both mRNA and protein levels. MeRIP-qPCR showed that PCIF1 suppression significantly reduced m6A levels on CNOT6 mRNA, and rescue experiments confirmed the requirement for PCIF1's methyltransferase activity, establishing m6A modification as a mechanism controlling CNOT6 mRNA stability. siRNA knockdown; MeRIP-qPCR; Western blot; rescue with methyltransferase-dead mutant Cells Medium 39451207
2026 CNOT6, but not its paralog CNOT6L, is an essential post-transcriptional regulator of neonatal growth: loss of Cnot6 causes severe growth retardation, multi-organ hypoplasia, and increased perinatal mortality. Mechanistically, Cnot6 deficiency elevates hepatic Fgf21 mRNA expression, suppresses the IGF1-IGFBP1 axis, and reprograms liver transcriptional networks, identifying Fgf21 mRNA as a direct CNOT6 decay target that limits anabolic metabolism during the neonatal period. Cnot6 knockout mouse model; hepatic transcriptome analysis; mRNA stability assay; metabolic phenotyping bioRxivpreprint Medium 41757057
2025 ENO1 lactylation at K71 (facilitated by the lactyltransferase P300) reduces binding of TRIM21 mRNA to ENO1, preventing CNOT6 recruitment and thereby stabilizing TRIM21 mRNA in endothelial cells during sepsis. This establishes that ENO1-CNOT6 interaction and mRNA decay depend on the lactylation state of ENO1. Co-immunoprecipitation; RNA immunoprecipitation (RIP); RT-qPCR; Western blot; post-translational modification mass spectrometry Clinical and translational medicine Medium 41532698

Source papers

Stage 0 corpus · 46 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2021 ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1. Nature cancer 172 35121990
2012 The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. Nucleic acids research 113 22977175
2011 The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence. Molecular biology of the cell 99 21233283
2019 Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation. Nature communications 87 31320642
2012 The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. PloS one 64 23236473
2012 Deadenylation of cytoplasmic mRNA by the mammalian Ccr4-Not complex. Biochemical Society transactions 61 22817755
2016 miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53-p21 and p16-pRB pathways. Biochimica et biophysica acta 51 26792405
2014 Noncoding RNA-related polymorphisms in pediatric acute lymphoblastic leukemia susceptibility. Pediatric research 50 24618566
2013 Identification and characterization of FGF2-dependent mRNA: microRNA networks during lens fiber cell differentiation. G3 (Bethesda, Md.) 42 24142921
2012 Alterations of deadenylase expression in acute leukemias: evidence for poly(a)-specific ribonuclease as a potential biomarker. Acta haematologica 40 22614729
2015 Lentiviral vector-mediated insertional mutagenesis screen identifies genes that influence androgen independent prostate cancer progression and predict clinical outcome. Molecular carcinogenesis 39 26512949
2008 Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1. The Journal of biological chemistry 39 18180299
2011 Distinct expression patterns of the subunits of the CCR4-NOT deadenylase complex during neural development. Biochemical and biophysical research communications 38 21741365
2020 Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. RNA biology 37 31924127
2013 Heterogeneity and complexity within the nuclease module of the Ccr4-Not complex. Frontiers in genetics 33 24391663
2021 The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 31 34026442
2018 Role of Cnot6l in maternal mRNA turnover. Life science alliance 31 30456367
2015 The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module. The Biochemical journal 31 25944446
2014 Deadenylase depletion protects inherited mRNAs in primordial germ cells. Development (Cambridge, England) 29 25100654
2019 mRNA levels are buffered upon knockdown of RNA decay and translation factors via adjustment of transcription rates in human HepG2 cells. RNA biology 22 31116665
2021 CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development. Cell reports 21 34788619
2019 Transcriptome profiling of longissimus thoracis muscles identifies highly connected differentially expressed genes in meat type sheep of India. PloS one 21 31170190
2020 Silencing of CCR4-NOT complex subunits affects heart structure and function. Disease models & mechanisms 20 32471864
2016 Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemia. Haematologica 20 27151989
2018 CNOT6 regulates a novel pattern of mRNA deadenylation during oocyte meiotic maturation. Scientific reports 17 29717177
2024 Mendelian randomization reveals potential causal relationships between cellular senescence-related genes and multiple cancer risks. Communications biology 16 39215079
2016 The CCR4-NOT deadenylase activity contributes to generation of induced pluripotent stem cells. Biochemical and biophysical research communications 12 27037025
2014 Genetic determinants in the development of sensitization to environmental allergens in early childhood. Immunity, inflammation and disease 11 25505553
2008 hCCR4/cNOT6 targets DNA-damage response proteins. Cancer letters 11 18818012
2019 CNOT2 facilitates dengue virus infection via negatively modulating IFN-Independent Non-Canonical JAK/STAT pathway. Biochemical and biophysical research communications 10 31155293
2022 CNOT6: A Novel Regulator of DNA Mismatch Repair. Cells 9 35159331
2016 Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk-A re-analysis of eight GWASs. Molecular carcinogenesis 9 27805284
2021 Human Ccr4 and Caf1 Deadenylases Regulate Proliferation and Tumorigenicity of Human Gastric Cancer Cells via Modulating Cell Cycle Progression. Cancers 8 33671234
2024 M2 Macrophage Classification of Colorectal Cancer Reveals Intrinsic Connections with Metabolism Reprogramming and Clinical Characteristics. Pharmacogenomics and personalized medicine 6 39011168
2023 The CARBON CATABOLITE REPRESSION 4A-mediated RNA deadenylation pathway acts on the transposon RNAs that are not regulated by small RNAs. The New phytologist 4 38009859
2024 CNOT6L deadenylase suppresses cardiac remodeling in heart failure through downregulation of tenascin-C mRNA. The Journal of pharmacology and experimental therapeutics 3 40023604
2022 Integrated Deadenylase Genetic Association Network and Transcriptome Analysis in Thoracic Carcinomas. Molecules (Basel, Switzerland) 3 35630580
2020 Importance of CNOT8 Deadenylase Subunit in DNA Damage Responses Following Ionizing Radiation (IR). Reports of biochemistry & molecular biology 3 33178865
2025 Variety Effect on Peelability and Mechanisms of Action of Late-Ripening Citrus Fruits. Plants (Basel, Switzerland) 2 40364378
2024 Cap-Specific m6Am Methyltransferase PCIF1/CAPAM Regulates mRNA Stability of RAB23 and CNOT6 through the m6A Methyltransferase Activity. Cells 2 39451207
2024 The Legionella pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4-NOT. mSphere 2 39699231
2025 RNA triple helix assembled by the poly(A) tail enhances retrotransposon mobilization by preventing RNA deadenylation. Proceedings of the National Academy of Sciences of the United States of America 1 41004225
2024 Discovery of Substituted 5-(2-Hydroxybenzoyl)-2-Pyridone Analogues as Inhibitors of the Human Caf1/CNOT7 Ribonuclease. Molecules (Basel, Switzerland) 1 39339346
2026 Targeting the lactylation of ENO1 alleviates endothelial dysfunction in sepsis. Clinical and translational medicine 0 41532698
2026 CNOT6 deadenylase safeguards postnatal growth and metabolic transition via Fgf21 mRNA decay. bioRxiv : the preprint server for biology 0 41757057
2025 Discovery of Drug-like Inhibitors of the Human Caf1/CNOT7 poly(A)-Selective Nuclease Using Compound Screening. Biomolecules 0 41301481

Missed literature

Know a paper Affinage missed for CNOT6? Flag it for the maintainers and the community.

No submissions yet.