Affinage

ANGPTL2

Angiopoietin-related protein 2 · UniProt Q9UKU9

Length
493 aa
Mass
57.1 kDa
Annotated
2026-04-28
100 papers in source corpus 11 papers cited in narrative 11 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ANGPTL2 is a secreted, multimeric glycoprotein that functions as a paracrine and autocrine mediator of inflammation, tissue remodeling, and tumor metastasis across vascular, cardiac, adipose, and renal compartments. It signals through at least two identified receptors—LILRB2 on hematopoietic/immune cells, requiring ligand multimerization for activation (PMID:24899623), and CD146 on adipocytes, where it engages a CREB-dependent positive feedback loop to drive adipogenesis (PMID:33747748)—and activates distinct intracellular cascades including NF-κB in endothelial cells (PMID:24526691), integrin α5β1/p38 MAPK/MMP in tumor cells (PMID:24448647), AKT-SERCA2a in cardiomyocytes (PMID:27677409), and MEK/ERK in renal epithelial cells (PMID:31632523). Its activity is negatively regulated by TLL1-mediated proteolytic cleavage, which generates inactive fragments (PMID:24448647), and its expression is upregulated by the transcription factors NFATc, ATF2, and c-Jun in aggressive tumor cells and by NFATc1 nuclear translocation in bone marrow macrophages (PMID:22345152, PMID:34801597).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 2012 High

    Establishing that ANGPTL2 is not merely a circulating factor but an autocrine/paracrine driver of tumor cell invasion, answering whether tumor cells themselves use ANGPTL2 to promote metastasis and identifying NFATc/ATF2/c-Jun as transcriptional activators of ANGPTL2 in aggressive tumors.

    Evidence RNAi knockdown and overexpression in tumor cells with in vitro invasion assays and xenograft mouse models

    PMID:22345152

    Open questions at the time
    • Receptor on tumor cells mediating autocrine signaling not identified
    • Relative contribution of each transcription factor (NFATc, ATF2, c-Jun) to ANGPTL2 expression not dissected
  2. 2013 High

    Demonstrating that the tissue source of ANGPTL2 matters: perivascular adipose tissue is a functionally relevant secretory source that accelerates vascular injury responses, establishing ANGPTL2 as a paracrine adipokine in vascular inflammation.

    Evidence Reciprocal adipose tissue transplantation from Angptl2-transgenic and knockout mice in wire-injury models

    PMID:23333801

    Open questions at the time
    • Receptor on vascular smooth muscle cells or endothelium mediating perivascular ANGPTL2 action not identified
    • Downstream signaling pathway in neointimal cells not delineated
  3. 2014 High

    Resolving two critical questions simultaneously: (1) endothelial cell-derived ANGPTL2 drives atherosclerosis via NF-κB-dependent monocyte recruitment, and (2) in tumor cells ANGPTL2 signals through integrin α5β1/p38 MAPK/MMPs while TLL1 protease cleavage inactivates the protein—establishing that context-specific receptor–pathway coupling and proteolytic regulation control ANGPTL2 activity.

    Evidence ApoE−/−×Angptl2−/− knockout mice with bone marrow transplantation for vascular studies; in vitro protease cleavage reconstitution, integrin/MMP signaling assays, and xenograft models for tumor studies

    PMID:24448647 PMID:24526691

    Open questions at the time
    • Identity of endothelial ANGPTL2 receptor for NF-κB activation unknown
    • Structural basis of TLL1 cleavage site not mapped at residue resolution
  4. 2014 High

    Identifying LILRB2 as a receptor for ANGPTL2 and demonstrating that ligand multimerization is essential for receptor activation, answering how ANGPTL2 engages immune-inhibitory receptor signaling on hematopoietic stem cells.

    Evidence Co-immunoprecipitation, LILRB2 Ig-domain mutagenesis, binding assays, and hematopoietic stem cell expansion functional readout

    PMID:24899623

    Open questions at the time
    • Downstream signaling events linking LILRB2 activation to HSC expansion not fully mapped
    • Whether LILRB2 mediates ANGPTL2 effects in non-hematopoietic contexts unknown
  5. 2015 Medium

    Dissecting that ANGPTL2 activates two separable signaling arms in osteosarcoma—PI3K/AKT for cell survival versus p38 MAPK/MMP for migration—and showing these can be pharmacologically uncoupled.

    Evidence Recombinant ANGPTL2 treatment with GDC-0152 (IAP antagonist) in osteosarcoma cells; Western blot and zymography readouts

    PMID:25651778

    Open questions at the time
    • Single cell line used; generalizability across tumor types not tested
    • Receptor upstream of PI3K/AKT arm not identified
  6. 2016 High

    Establishing ANGPTL2 as a cardiodepressant factor: cardiac overexpression inactivates AKT-SERCA2a signaling and impairs contractility, while knockout enhances cardiac function, answering whether ANGPTL2 directly regulates myocardial performance.

    Evidence Cardiac-specific transgenic overexpression, global Angptl2 knockout, and transverse aortic constriction model with AKT/SERCA2a signaling and metabolic readouts

    PMID:27677409

    Open questions at the time
    • Cardiac receptor for ANGPTL2 not identified
    • Whether circulating versus local cardiac ANGPTL2 is the relevant pool in heart failure not resolved
  7. 2019 Medium

    Extending ANGPTL2's pro-fibrotic role to the kidney: ANGPTL2 promotes renal fibrosis through MEK/ERK/Nrf-1 signaling and suppresses protective autophagy, linking ANGPTL2 to diabetic nephropathy pathogenesis.

    Evidence siRNA knockdown in HK-2 cells under high glucose, streptozotocin-induced diabetic rat model, MEK inhibitor rescue

    PMID:31632523

    Open questions at the time
    • Renal receptor for ANGPTL2 unknown
    • Whether Nrf-1 is a direct or indirect target of ERK in this context not resolved
    • Single-lab study without independent replication
  8. 2021 High

    Identifying CD146 as a second defined receptor for ANGPTL2, this time on adipocytes, and demonstrating a CREB-dependent feedforward loop that drives adipogenesis—providing the first receptor-level explanation for ANGPTL2's role in obesity.

    Evidence Co-immunoprecipitation/binding assays, CD146 knockout, anti-CD146 antibody treatment in vivo, adipogenesis assays

    PMID:33747748

    Open questions at the time
    • Whether CD146 mediates ANGPTL2 signaling in non-adipocyte contexts (e.g. endothelium) not tested
    • Structural basis of ANGPTL2–CD146 interaction not determined
  9. 2021 Medium

    Revealing a tumor microenvironment feedback loop: tumor-derived extracellular vesicle miR-378a-3p activates NFATc1 in bone marrow macrophages, upregulating Angptl2 secretion that in turn promotes prostate cancer progression.

    Evidence EV uptake experiments, Dyrk1a inhibition, NFATc1 nuclear translocation assays, in vitro and in vivo tumor progression models

    PMID:34801597

    Open questions at the time
    • Receptor on tumor cells through which macrophage-derived ANGPTL2 acts not identified
    • Whether this EV-mediated loop operates in other cancer types unknown
    • Single-lab finding

Open questions

Synthesis pass · forward-looking unresolved questions
  • The endothelial and cardiac receptors for ANGPTL2 remain unidentified; the structural determinants of multimerization-dependent receptor selectivity between LILRB2 and CD146 are unknown; and it is unclear how TLL1 cleavage is regulated in vivo to control ANGPTL2 bioactivity across tissues.
  • No structural model of ANGPTL2 multimer or receptor complexes
  • Endothelial and cardiac ANGPTL2 receptors not identified
  • In vivo regulation of TLL1 cleavage of ANGPTL2 not characterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 3 GO:0098772 molecular function regulator activity 2
Localization
GO:0005576 extracellular region 5
Pathway
R-HSA-162582 Signal Transduction 6 R-HSA-1643685 Disease 4 R-HSA-168256 Immune System 3
Partners
CD146LILRB2SERCA2ATLL1

Evidence

Reading pass · 11 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2014 ANGPTL2 activates proinflammatory NF-κB signaling in endothelial cells and increases monocyte/macrophage chemotaxis; endothelial cell-derived ANGPTL2 accelerates vascular inflammation leading to endothelial dysfunction and atherosclerosis progression, demonstrated by Angptl2 knockout in ApoE-deficient mice attenuating plaque formation and bone marrow transplantation experiments identifying endothelial cells as the critical source. Knockout mouse model (ApoE-/- × Angptl2-/-), transgenic overexpression (Tie2-Angptl2 Tg), bone marrow transplantation, in vitro NF-κB signaling assay, monocyte chemotaxis assay Arteriosclerosis, thrombosis, and vascular biology High 24526691
2012 Tumor cell-derived ANGPTL2 promotes tumor cell motility and invasion in an autocrine/paracrine manner; ANGPTL2 expression in primary tumor cells accelerates metastasis in xenograft models, and transcription factors NFATc, ATF2, and c-Jun upregulate ANGPTL2 expression in aggressive tumor cells. In vitro migration/invasion assays, xenograft mouse models, RNAi knockdown of ANGPTL2, transcription factor overexpression Cancer research High 22345152
2014 ANGPTL2 promotes osteosarcoma metastasis through integrin α5β1, p38 MAPK signaling, and matrix metalloproteinases; the TLL1 (tolloid-like 1) protease cleaves ANGPTL2 into fragments that do not enhance tumor progression, and ANGPTL2 expression increases via DNA demethylation under hypoxic/serum-starved conditions. Xenograft mouse models, integrin signaling assays, MMP activity assays, in vitro protease cleavage assay, methylation analysis Science signaling High 24448647
2014 Angptl2 expressed in mammalian cells forms high-molecular-weight (multimeric) species, and ligand multimerization is required for activation of the immune inhibitory receptor LILRB2 for downstream signaling; a novel motif in the first and fourth Ig domains of LILRB2 is necessary for binding and activation by Angptl2. Co-immunoprecipitation, binding assays, LILRB2 domain mutagenesis, downstream signaling assays, hematopoietic stem cell expansion assay Blood High 24899623
2016 ANGPTL2 overexpression in the heart causes cardiac dysfunction by inactivating AKT and SERCA2a signaling and decreasing myocardial energy metabolism; Angptl2 knockout mice show increased left ventricular contractility and upregulated AKT-SERCA2a signaling; ANGPTL2-knockdown in pressure-overloaded mice ameliorates cardiac dysfunction. Cardiac-specific transgenic overexpression, Angptl2 knockout mice, pressure overload model (transverse aortic constriction), AKT/SERCA2a signaling assays, metabolic measurements Nature communications High 27677409
2013 Perivascular adipose tissue-secreted Angptl2 accelerates neointimal hyperplasia and vascular inflammation after endovascular injury; demonstrated by adipose tissue transplantation experiments showing that Angptl2-overexpressing perivascular fat accelerates and Angptl2-knockout perivascular fat attenuates neointimal hyperplasia. Adipose tissue transplantation, transgenic (aP2-Angptl2) and knockout (Angptl2-/-) mice, wire-injury model, histology and RT-PCR Journal of molecular and cellular cardiology High 23333801
2021 CD146 is identified as a novel receptor for ANGPTL2 on adipocytes; ANGPTL2 binds CD146 to activate CREB, which upregulates CD146 expression; CD146 ablation suppresses adipogenesis in preadipocytes and lipid accumulation in mature adipocytes, and anti-CD146 antibodies inhibit obesity by disrupting ANGPTL2-CD146 interactions. Co-immunoprecipitation/binding assays, CD146 knockout, CREB signaling assays, adipogenesis assays, anti-CD146 antibody treatment in vivo Advanced science High 33747748
2019 ANGPTL2 promotes renal fibrosis in diabetic nephropathy through the MEK/ERK/Nrf-1 pathway; ANGPTL2 knockdown in high-glucose-stimulated HK-2 cells causes increases in MEK, p-ERK, Nrf-1, autophagy markers (LC3II, beclin1), and decreases in fibrotic markers (fibronectin, collagen I/IV) and pro-inflammatory cytokines. ANGPTL2 knockdown (siRNA) in HK-2 cells, streptozotocin-induced diabetic rat model, Western blot for MEK/ERK/Nrf-1 pathway, ELISA for inflammatory cytokines, pathway inhibitor rescue experiments American journal of translational research Medium 31632523
2021 miR-378a-3p from tumor-derived extracellular vesicles is taken up by bone marrow macrophages where it inhibits Dyrk1a, enabling Nfatc1 nuclear translocation and upregulating Angptl2 expression; increased Angptl2 secretion from macrophages then promotes prostate cancer progression in a feedback loop. In vitro and in vivo functional assays, EV uptake experiments, Dyrk1a inhibition, Nfatc1 nuclear translocation assays, Angptl2 expression measurement Cancer letters Medium 34801597
2014 Diverse roles review: ANGPTL2 maintains tissue homeostasis by promoting adaptive inflammation and subsequent tissue reconstruction; excess ANGPTL2 signaling induced by prolonged stress promotes chronic inflammation and irreversible tissue remodeling leading to metabolic diseases. Review synthesizing data from multiple mouse genetic models (transgenic, knockout) across multiple tissues Trends in endocrinology and metabolism Medium 24746520
2015 ANGPTL2 activates PI3K/AKT but not p38MAPK-dependent cell growth and survival in osteosarcoma cells; treatment with IAP antagonist GDC-0152 suppresses ANGPTL2-induced PI3K/AKT activation and reduces cell growth and apoptosis resistance, but does not block ANGPTL2-induced p38MAPK, MMP-9/MMP-2 expression, or migration. MTT cell viability assay, migration chamber assay, Western blot for PI3K/AKT/p38MAPK, qRT-PCR and gelatin zymography for MMPs, recombinant human ANGPTL2 treatment International journal of oncology Medium 25651778

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2005 Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. The Journal of cell biology 559 15684033
2001 Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nature cell biology 481 11231575
2001 Crystal structure of Arp2/3 complex. Science (New York, N.Y.) 413 11721045
2012 New insights into the regulation and cellular functions of the ARP2/3 complex. Nature reviews. Molecular cell biology 391 23212475
2018 Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. Nature 312 29925947
2008 Arp2/3 complex interactions and actin network turnover in lamellipodia. The EMBO journal 242 18309290
2005 Protein complexes regulating Arp2/3-mediated actin assembly. Current opinion in cell biology 209 16343889
2011 Arp2/3 complex is bound and activated by two WASP proteins. Proceedings of the National Academy of Sciences of the United States of America 173 21676863
2018 The Arp2/3 Regulatory System and Its Deregulation in Cancer. Physiological reviews 157 29212790
2003 Integration of signals to the Arp2/3 complex. Current opinion in cell biology 157 12517700
2010 WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyond. Trends in cell biology 150 20888769
2010 WASH and the Arp2/3 complex regulate endosome shape and trafficking. Cytoskeleton (Hoboken, N.J.) 147 20175130
2011 Arp2/3 complex regulates asymmetric division and cytokinesis in mouse oocytes. PloS one 143 21494665
2011 Filopodia initiation: focus on the Arp2/3 complex and formins. Cell adhesion & migration 141 21975549
2000 How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures. Current opinion in cell biology 141 10679362
2014 Diverse roles of ANGPTL2 in physiology and pathophysiology. Trends in endocrinology and metabolism: TEM 137 24746520
1999 The world according to Arp: regulation of actin nucleation by the Arp2/3 complex. Trends in cell biology 135 10511705
2014 Role of endothelial cell-derived angptl2 in vascular inflammation leading to endothelial dysfunction and atherosclerosis progression. Arteriosclerosis, thrombosis, and vascular biology 132 24526691
2006 IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway. The Journal of biological chemistry 125 17085436
2009 The annealing helicase HARP protects stalled replication forks. Genes & development 123 19793864
2008 A SPIKE1 signaling complex controls actin-dependent cell morphogenesis through the heteromeric WAVE and ARP2/3 complexes. Proceedings of the National Academy of Sciences of the United States of America 118 18308939
2012 Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis. Cancer research 115 22345152
2000 Actin-based motility of pathogens: the Arp2/3 complex is a central player. Cellular microbiology 110 11207576
2014 The secreted protein ANGPTL2 promotes metastasis of osteosarcoma cells through integrin α5β1, p38 MAPK, and matrix metalloproteinases. Science signaling 108 24448647
2017 Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading. The Journal of cell biology 98 28912124
2016 The Diverse Family of Arp2/3 Complexes. Trends in cell biology 90 27595492
2005 Phosphoregulation of Arp2/3-dependent actin assembly during receptor-mediated endocytosis. Nature cell biology 90 15711538
2008 WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2. Nature cell biology 89 18516090
2020 The cell pushes back: The Arp2/3 complex is a key orchestrator of cellular responses to environmental forces. Current opinion in cell biology 86 32977244
2014 A motif in LILRB2 critical for Angptl2 binding and activation. Blood 85 24899623
2016 Function and regulation of the Arp2/3 complex during cell migration in diverse environments. Current opinion in cell biology 83 27164504
2014 Regulation of focal adhesion formation by a vinculin-Arp2/3 hybrid complex. Nature communications 83 24781749
2007 Regulation of N-WASP and the Arp2/3 complex by Abp1 controls neuronal morphology. PloS one 80 17476322
2007 Src, cortactin and Arp2/3 complex are required for E-cadherin-mediated internalization of Listeria into cells. Cellular microbiology 78 17627624
2004 The WASP-Arp2/3 pathway: genetic insights. Current opinion in cell biology 77 15196561
2004 Association of Cdc42/N-WASP/Arp2/3 signaling pathway with Golgi membranes. Traffic (Copenhagen, Denmark) 76 15479449
2015 Initiation of lamellipodia and ruffles involves cooperation between mDia1 and the Arp2/3 complex. Journal of cell science 70 26349808
2013 Perivascular adipose tissue-secreted angiopoietin-like protein 2 (Angptl2) accelerates neointimal hyperplasia after endovascular injury. Journal of molecular and cellular cardiology 70 23333801
2004 Involvement of Arp2/3 complex in the process of colorectal carcinogenesis. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 70 14990971
2004 Activation of Arp2/3 complex: addition of the first subunit of the new filament by a WASP protein triggers rapid ATP hydrolysis on Arp2. PLoS biology 70 15094799
1999 Signalling to actin: the Cdc42-N-WASP-Arp2/3 connection. Chemistry & biology 69 10467124
2016 Actin-Related Protein 2 (ARP2) and Virus-Induced Filopodia Facilitate Human Respiratory Syncytial Virus Spread. PLoS pathogens 64 27926942
2004 Decreased expression of the seven ARP2/3 complex genes in human gastric cancers. Cancer letters 62 15279900
2020 Cryo-EM structure of NPF-bound human Arp2/3 complex and activation mechanism. Science advances 59 32917641
2016 ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism. Nature communications 59 27677409
2023 ANGPTL2+cancer-associated fibroblasts and SPP1+macrophages are metastasis accelerators of colorectal cancer. Frontiers in immunology 56 37691929
2013 Silencing of the ARP2/3 complex disturbs pancreatic cancer cell migration. Anticancer research 56 23267127
2014 Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens. The Journal of biological chemistry 55 24469447
2001 HARP induces angiogenesis in vivo and in vitro: implication of N or C terminal peptides. Biochemical and biophysical research communications 52 11264008
2007 Cdc42 and ARP2/3-independent regulation of filopodia by an integral membrane lipid-phosphatase-related protein. Journal of cell science 48 17200142
1999 Glycosaminoglycans differentially bind HARP and modulate its biological activity. The Journal of biological chemistry 47 10075664
2023 From WRC to Arp2/3: Collective molecular mechanisms of branched actin network assembly. Current opinion in cell biology 46 36868090
2020 SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization. Nature cell biology 46 32572169
2012 Exo70 stimulates the Arp2/3 complex for lamellipodia formation and directional cell migration. Current biology : CB 46 22748316
2011 Cortical actin binding protein cortactin mediates ENaC activity via Arp2/3 complex. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 44 21536685
2016 Structural Basis of Arp2/3 Complex Inhibition by GMF, Coronin, and Arpin. Journal of molecular biology 42 27939292
2003 Caldesmon inhibits Arp2/3-mediated actin nucleation. The Journal of biological chemistry 42 12637566
2021 CD146 is a Novel ANGPTL2 Receptor that Promotes Obesity by Manipulating Lipid Metabolism and Energy Expenditure. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 40 33747748
2008 Arp2/3 overexpression contributed to pathogenesis, growth and invasion of gastric carcinoma. Anticancer research 40 18751399
2017 Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice. Blood advances 39 29104956
2012 Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. Proceedings of the National Academy of Sciences of the United States of America 39 22689987
2017 High Circulating Levels of ANGPTL2: Beyond a Clinical Marker of Systemic Inflammation. Oxidative medicine and cellular longevity 38 29138671
2016 Crucial roles of the Arp2/3 complex during mammalian corticogenesis. Development (Cambridge, England) 38 27385014
2021 Tumor-derived miR-378a-3p-containing extracellular vesicles promote osteolysis by activating the Dyrk1a/Nfatc1/Angptl2 axis for bone metastasis. Cancer letters 37 34801597
2008 Structure and biochemical properties of fission yeast Arp2/3 complex lacking the Arp2 subunit. The Journal of biological chemistry 36 18640983
2021 Induced Arp2/3 Complex Depletion Increases FMNL2/3 Formin Expression and Filopodia Formation. Frontiers in cell and developmental biology 35 33598464
2019 ANGPTL2 regulates autophagy through the MEK/ERK/Nrf-1 pathway and affects the progression of renal fibrosis in diabetic nephropathy. American journal of translational research 34 31632523
2015 The Nck-interacting kinase NIK increases Arp2/3 complex activity by phosphorylating the Arp2 subunit. The Journal of cell biology 34 25601402
2019 B cells extract antigens at Arp2/3-generated actin foci interspersed with linear filaments. eLife 32 31815664
2013 Aldolase sequesters WASP and affects WASP/Arp2/3-stimulated actin dynamics. Journal of cellular biochemistry 32 23495010
2012 The actin regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil chemotaxis. The Journal of biological chemistry 31 22679023
2020 Anti-inflammatory activity of berberine in non-alcoholic fatty liver disease via the Angptl2 pathway. BMC immunology 30 32429849
2019 Cellular and pathophysiological consequences of Arp2/3 complex inhibition: role of inhibitory proteins and pharmacological compounds. Cellular and molecular life sciences : CMLS 28 31073744
2015 GDC-0152 attenuates the malignant progression of osteosarcoma promoted by ANGPTL2 via PI3K/AKT but not p38MAPK signaling pathway. International journal of oncology 28 25651778
2011 The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1. EMBO reports 27 21525954
2007 Enhanced expression of ANGPTL2 in the microvascular lesions of diabetic glomerulopathy. Nephron. Experimental nephrology 27 17347581
2020 Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation. JCI insight 26 31961823
2018 Angptl2 deficiency attenuates paraquat (PQ)-induced lung injury in mice by altering inflammation, oxidative stress and fibrosis through NF-κB pathway. Biochemical and biophysical research communications 26 29852175
2016 WASP family proteins, more than Arp2/3 activators. Biochemical Society transactions 26 27911716
2023 Genomic instability caused by Arp2/3 complex inactivation results in micronucleus biogenesis and cellular senescence. PLoS genetics 25 36706133
2023 ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization. eLife 24 37057894
2017 ANGPTL2　- A New Causal Player in Accelerating Heart Disease Development in the Aging. Circulation journal : official journal of the Japanese Circulation Society 24 28867689
2015 WHAMM links actin assembly via the Arp2/3 complex to autophagy. Autophagy 24 26291929
2010 Molecular dynamics simulations of Arp2/3 complex activation. Biophysical journal 24 20959098
2022 Molecular mechanism of Arp2/3 complex inhibition by Arpin. Nature communications 23 35110533
2019 Capping Protein Insulates Arp2/3-Assembled Actin Patches from Formins. Current biology : CB 23 31495586
2012 Abp1 utilizes the Arp2/3 complex activator Scar/WAVE in bristle development. Journal of cell science 23 22467854
2018 Enhanced ANGPTL2 expression in adipose tissues and its association with insulin resistance in obese women. Scientific reports 22 30228336
2004 Dendritic branching and homogenization of actin networks mediated by arp2/3 complex. Physical review letters 22 15697951
2021 Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence. International journal of molecular sciences 21 34830112
2017 An Amish founder mutation disrupts a PI(3)P-WHAMM-Arp2/3 complex-driven autophagosomal remodeling pathway. Molecular biology of the cell 21 28720660
2010 Giardia and Cryptosporidium in harp and hooded seals from the Gulf of St. Lawrence, Canada. Veterinary parasitology 21 20594649
2023 ArpC5 isoforms regulate Arp2/3 complex-dependent protrusion through differential Ena/VASP positioning. Science advances 19 36662867
2021 The Arp2/3 Inhibitory Protein Arpin Is Required for Intestinal Epithelial Barrier Integrity. Frontiers in cell and developmental biology 19 34012961
2018 Arabidopsis thaliana plants lacking the ARP2/3 complex show defects in cell wall assembly and auxin distribution. Annals of botany 19 29293873
2016 Lower Methylation of the ANGPTL2 Gene in Leukocytes from Post-Acute Coronary Syndrome Patients. PloS one 19 27101308
2004 Harp (harmonin-interacting, ankyrin repeat-containing protein), a novel protein that interacts with harmonin in epithelial tissues. Genes to cells : devoted to molecular & cellular mechanisms 19 15461667
2018 Stigmasterol activates Cdc42-Arp2 and Erk1/2-Creb pathways to enrich glutamatergic synapses in cultures of brain neurons. Nutrition research (New York, N.Y.) 18 30055776
2017 Circulating ANGPTL2 Levels Increase in Humans and Mice Exhibiting Cardiac Dysfunction. Circulation journal : official journal of the Japanese Circulation Society 18 28890470
2007 Activation of p61Hck triggers WASp- and Arp2/3-dependent actin-comet tail biogenesis and accelerates lysosomes. The Journal of biological chemistry 18 17500055