Integrin alpha-5 · UniProt P08648
ITGA5 encodes the α5 subunit (CD49e/VLA-5) of the α5β1 fibronectin receptor, a transmembrane adhesion molecule that engages fibronectin and other extracellular-matrix ligands to couple cell-matrix contact to intracellular signaling and to control adhesion, spreading, migration, invasion, EMT, and angiogenesis across diverse normal and malignant tissues (PMID:7534750, PMID:20564209, PMID:36193075). Upon ligand engagement, ITGA5 nucleates signaling through FAK-anchored cascades — FAK/AKT in gastric cancer (PMID:36193075), FAK/Src in fibronectin-driven chemoresistant breast cancer (PMID:35338412), FAK/ERK whose suppression blocks gastric-cancer motility (PMID:35257941), and a TAK-1/NF-κB axis driving diabetic-retinopathy neovascularization (PMID:40410450) — and through direct activation of PI3K/AKT, with ITGA5 binding PI3K in vitro to promote EMT and anoikis resistance (PMID:41772919, PMID:36999964, PMID:41651176). This receptor function repeatedly drives a pro-angiogenic/pro-lymphangiogenic program by elevating VEGFA and VEGF-C secretion (PMID:36999964, PMID:37338646) and operates in fibrogenic contexts upstream of PI3K/Akt/mTOR collagen synthesis and TGF-β/Smad signaling (PMID:28689917, PMID:40023972). ITGA5 abundance is gated post-translationally — O-GlcNAcylation by OGT and N-glycosylation stabilize the protein (PMID:31202709, PMID:40084746), while the DTX1 E3 ligase ubiquitinates ITGA5 at K137 for proteasomal degradation (PMID:42090073) — and transcriptionally by activators (GBX2, HOXD8 downstream of METTL3 m6A, HIF-1A, RPRD1A/c-JUN) and repressors including promoter hypermethylation and multiple miRNAs such as miR-326 and miR-128-3p (PMID:35672622, PMID:38818480, PMID:35338412, PMID:34263426, PMID:42171939, PMID:36669384). ITGA5 forms functional complexes with the cytoskeletal adaptor ACTN1, with FAPα, and with YES1 kinase, IMP3, and PTEN, and is transferred between cells in extracellular vesicles to confer cancer stem-cell properties and remodel the tumor microenvironment (PMID:36742137, PMID:37979759, PMID:39574133, PMID:40385029, PMID:38993558, PMID:40084746, PMID:35149589). Beyond cancer, ITGA5 mediates leukocyte recruitment and adhesion, stem/progenitor differentiation, myometrial contractility, and neuronal synaptic architecture via a PTEN/AKT interaction (PMID:11254723, PMID:27363302, PMID:15635129, PMID:38993558).
Establishing the genomic identity of the fibronectin receptor alpha subunit gave the molecular anchor for all subsequent functional study.
Evidence Somatic cell hybrid mapping with cDNA probes localizing FNRA to chromosome 12
Functional blocking assays first showed that α5β1 mediates a distinct, integrin-redundant adhesion/migration program in immune cells, distinguishing it from VLA-4 and β2 integrins.
Evidence Transwell migration with blocking mAbs across HUVEC and synovial fibroblast barriers (monocytes); in vivo mAb blockade in LPS-induced lung inflammation (neutrophils)
Loss- and gain-of-function in breast cancer cells resolved the context-dependent role of ITGA5 — promoting fibronectin adhesion/spreading while its growth effect is reversed by matrix engagement — and identified promoter hypermethylation as a silencing mechanism.
Evidence Overexpression and siRNA in breast cancer lines with growth/adhesion/migration assays; bisulfite sequencing
Pharmacological and genetic targeting placed ITGA5 upstream of PI3K/Akt/mTOR-driven collagen synthesis, linking the receptor to fibrogenesis beyond cancer.
Evidence SILAC proteomics, docking, siRNA/overexpression with pathway Western blots, and in vivo liver fibrosis model
Two advances defined how ITGA5 protein level is post-translationally controlled and how its activity supports the tumor stroma — O-GlcNAcylation stabilizes the protein, and ITGA5 in stellate cells drives desmoplasia that can be therapeutically reversed.
Evidence In vitro O-GlcNAcylation/IP assays plus xenograft (CRC); siRNA in pancreatic stellate cells with peptidomimetic inhibitor in co-injection and PDX PDAC models
A cluster of studies cemented ITGA5 as a fibronectin-triggered signaling hub feeding FAK/AKT, FAK/Src, and FAK/ERK to drive proliferation, invasion, angiogenesis/lymphangiogenesis, and chemoresistance, and identified transcriptional and miRNA regulators.
Evidence RNAi/overexpression with pathway Western blots, ChIP, luciferase, VEGFA/VEGF-C rescue, and xenografts across gastric, cervical, laryngeal, and breast cancer; EV proteomics for premetastatic niche
PMID:35149589 PMID:35257941 PMID:35338412 PMID:35672622 PMID:36193075 PMID:36438491 PMID:36999964 PMID:37338646
Co-IP studies began mapping ITGA5's direct protein partners and intercellular signaling roles, including the cytoskeletal adaptor ACTN1, the stromal complex with FAPα, and FN1-binding fibroblast subsets that shape immune microenvironments.
Evidence Co-IP with functional rescue (ACTN1, HNSCC); molecular docking and Co-IP (FAPα, periodontitis); single-cell/spatial transcriptomics and adoptive transfer (ITGA5+ synovial fibroblasts in arthritis)
PMID:36742137 PMID:37979759 PMID:39919897
EV-mediated transfer and direct kinase binding revealed a cell-non-autonomous mode in which ITGA5 cargo educates recipient cells — binding YES1 to confer stemness and engaging macrophages via SPP1 to drive immune escape — while CRISPR and N-glycosylation work refined how it is trafficked and stabilized.
Evidence CRISPR KO, EV transfer, Co-IP/MS (YES1, HCC); circRNA-driven N-glycosylation with RIP/pull-down, scRNA-seq, spatial transcriptomics (GBM exosomal ITGA5–SPP1); PTEN interaction by mass spectrometry with electrophysiology (Parkinson model)
PMID:38993558 PMID:39574133 PMID:40084746
Recent work mapped the precise post-translational control of ITGA5 stability and additional ligand- and partner-driven axes, including K137 ubiquitination by DTX1, IMP3-mediated metabolic reprogramming, and CTHRC1/CAF-derived ligands feeding PI3K/AKT.
Evidence Co-IP with ubiquitination site mapping and in vivo aortic-dissection model (DTX1); Co-IP/MS and RIP with HK2 rescue (IMP3); binding assays with scRNA-seq/spatial transcriptomics (CTHRC1, SPP1)
PMID:40385029 PMID:41651176 PMID:41758046 PMID:42090073
| Year | Finding | Method | Journal | Conf | PMIDs |
|---|---|---|---|---|---|
| 2001 | α5β1 integrin (CD49e/CD29, VLA-5) on neutrophils mediates β2-integrin-independent recruitment to endotoxin-induced lung inflammation; combined blockade of α4β1, α5β1, and β2 integrins with mAbs inhibited PMNL accumulation in the parenchyma by 79% and prevented pulmonary vascular/epithelial permeability. | In vivo antibody blocking (mAb to α5β1, α4β1, β2 integrins) in rat intratracheal LPS model; myeloperoxidase assay and BAL fluid cell counts | Journal of immunology | Medium | 11254723 |
| 1998 | VLA-5 (α5β1; CD49e/CD29) on monocytes mediates migration through synovial fibroblast barriers independently of CD18 and VLA-4; the inhibitory effect required prior blockade of CD11/CD18 to become apparent, and the ligand on synovial fibroblasts is distinct from VCAM-1. | Transwell migration assay with blocking mAbs against α5 (VLA-5), α4 (VLA-4), CD18, and VCAM-1 using HUVEC and human synovial fibroblast barriers; C5a and MCP-1 chemotactic gradients | Journal of immunology | Medium | 9552005 |
| 1995 | Functional surface expression of α5β1 integrin (CD49e/CD29) correlates with fibronectin adherence and disseminative spread of malignant B-cell lines in SCID mice; lines with non-functional or absent α5β1 did not disseminate. | Immunohistochemistry and flow cytometry for α5β1 expression; fibronectin adhesion assay in vitro; s.c. xenograft dissemination in SCID mice | International journal of cancer | Medium | 7534750 |
| 2005 | ITGA5 (α5 integrin) mRNA and protein are significantly upregulated in rat myometrium during late pregnancy and labor, with expression primarily in myometrial cell membranes; progesterone treatment blocked labor and sustained Itga5 expression, suggesting ITGA5/ITGB1 promotes cellular cohesion to develop a mechanical syncytium for uterine contractions. | qRT-PCR, immunoblot, and immunocytochemistry across pregnancy time-points in rat myometrium; progesterone treatment experiment | Biology of reproduction | Medium | 15635129 |
| 2010 | ITGA5 overexpression in MDA-MB-468 breast cancer cells inhibits cell growth, but adhesion to fibronectin reverses this growth inhibition; ITGA5 overexpression enhances cell adhesion and spreading to fibronectin while reducing migration. Knockdown of ITGA5 in MCF-7 cells also inhibits cell growth but has little effect on migration. Downregulation of ITGA5 in MDA-MB-468 is mediated by promoter hypermethylation. | ITGA5 overexpression and siRNA knockdown; cell growth assay, adhesion/spreading assay on fibronectin, migration assay; bisulfite sequencing for methylation | Journal of cellular biochemistry | Medium | 20564209 |
| 2010 | RNA interference-mediated knockdown of CD49e (ITGA5) in human thymic epithelial cells modulates expression of >100 genes including genes involved in thymocyte adhesion, integrin signaling, and F-actin stress fiber formation, and decreases adhesion of all CD4/CD8-defined thymocyte subsets to TEC. | siRNA knockdown of CD49e in human TEC line; transcriptomic profiling; thymocyte adhesion assay | BMC genomics | Medium | 21210968 |
| 2011 | Alcohol suppresses Nm23, which in turn increases ITGA5 expression, leading to increased breast cancer cell invasion; Nm23 overexpression suppresses ITGA5 upregulation and inhibits alcohol-induced invasion, and ITGA5 knockdown also inhibits alcohol-induced invasion, placing ITGA5 downstream of Nm23 in this pathway. | Ethanol treatment of T47D cells; Boyden chamber invasion assay; qRT-PCR array; Nm23 overexpression and ITGA5 siRNA knockdown; Western blot | Journal of experimental & clinical cancer research | Medium | 21838876 |
| 2015 | Downregulation of ITGA5 by shRNA lentivirus significantly reduces migration capacity of human dental pulp stem cells (hDPSCs) in a transwell assay. | Lentiviral shRNA knockdown of ITGA5 in hDPSCs; transwell migration assay | International journal of clinical and experimental pathology | Low | 26823759 |
| 2016 | ITGA5 knockdown reduces proliferation and adipogenic differentiation in human adipose-derived stem cells (ASCs), while ITGA5 transgenic overexpression impairs adipogenesis; these effects are distinct from ITGAV, which specifically regulates proliferation via p21/survivin/TAZ, while ITGA5 does not affect proliferation when knocked down. | siRNA knockdown and transgenic overexpression of ITGA5 (and ITGAV) in sorted ASCs; adipogenic differentiation assays; cell proliferation assay | Scientific reports | Medium | 27363302 |
| 2017 | Dioscin directly binds ITGA5 and acts as a potent ITGA5 inhibitor; ITGA5 silencing suppresses collagen synthesis via inhibition of the PI3K/Akt/mTOR pathway, reducing FN, FAK1, p-PI3K, p-Akt, p-mTOR, and collagen proteins in liver fibrosis. ITGA5 DNA transfection reverses dioscin's inhibitory effect on collagen expression through the PI3K/Akt pathway. | SILAC-based proteomics; molecular docking; siRNA and overexpression transfection of ITGA5 in LX-2 cells; Western blot for PI3K/Akt/mTOR pathway proteins; in vivo liver fibrosis model | Food and chemical toxicology | Medium | 28689917 |
| 2019 | O-GlcNAcylation of ITGA5 protein, mediated by OGT, increases ITGA5 protein stability and expression in colorectal cancer cells; elevated O-GlcNAcylation of ITGA5 promotes CRC cell growth and tumorigenesis. | Immunoprecipitation, in vitro O-GlcNAcylation assay, enzymatic labelling of O-GlcNAc; OGT inhibitor (PUGNAc/GlcN) treatment; CCK-8, flow cytometry, xenotransplantation | Experimental cell research | Medium | 31202709 |
| 2019 | ITGA5 knockdown in pancreatic stellate cells inhibits their differentiation into activated CAFs and reduces desmoplasia in vivo; a peptidomimetic ITGA5 inhibitor (AV3) reduces desmoplasia, decompresses blood vasculature, enhances tumor perfusion, and potentiates gemcitabine efficacy in pancreatic cancer xenograft and PDX models. | ITGA5 siRNA knockdown in hPSCs; in vivo co-injection and PDX PDAC models; histology; vascular perfusion assay; 3D heterospheroid model | Science advances | High | 31517053 |
| 2018 | MRTFA deficiency shifts perivascular progenitor fate from ITGA5+ fibrogenic progenitor cells (FPCs) to adipocyte precursors in adipose tissue during obesity, protecting against fibrosis; ITGA5+ Sca1−Sma+ITGA5+ FPCs are formed in adipose tissue during obesity and the ITGA5-MRTFA pathway governs their identity. | MRTFA knockout mice; flow cytometry and immunofluorescence identifying ITGA5+ FPC subpopulation; high-fat diet obesity model; histological fibrosis assessment | Cell reports | Medium | 29768198 |
| 2022 | ITGA5 in cervical cancer cells activates downstream PI3K-Akt signaling, increases VEGFA expression and secretion, and promotes endothelial tube formation; fibronectin (FN1) coating modulates ITGA5-mediated angiogenesis, and VEGFA supplementation reverses the decrease in tube formation caused by ITGA5 knockdown. | siRNA knockdown of ITGA5; tube formation assay, 3D spheroid sprout assay; Western blot for p-AKT and VEGFA; ELISA; FN1 coating/siRNA experiments | Cancer medicine | Medium | 36999964 |
| 2022 | ITGA5 promotes tumor progression in gastric cancer via activation of the FAK/AKT signaling pathway; ITGA5 silencing inhibits proliferation, invasion, migration, and xenograft growth, while overexpression promotes these functions. | ITGA5 siRNA and overexpression in gastric cancer cell lines; Western blot for FAK/AKT; in vitro proliferation/invasion/migration assays; in vivo xenograft model | Oxidative medicine and cellular longevity | Medium | 36193075 |
| 2022 | ITGA5 and ITGB1 overexpression in HCC cells promotes vasculogenic mimicry (VM) formation, reduces sensitivity to sorafenib, and aggravates hypoxia; VM formation contributes to sorafenib resistance. | Sorafenib-resistant HCC cell line construction; ITGA5/ITGB1 overexpression; CD31/PAS staining for VM; hypoxia probe by flow cytometry | Cancer medicine | Low | 35946175 |
| 2022 | FN1 drives chemoresistance in TNBC via its receptor ITGA5, activating downstream FAK/Src signaling; miR-326, which is repressed by hypoxia/HIF1A and ECM stiffness, targets ITGA5 to reverse FN1-driven chemoresistance. ITGA5 inhibition overcomes FN1-driven chemotherapy resistance in vitro and potentiates chemotherapy in vivo. | RNA/small RNA sequencing; ChIP for HIF1A; ITGA5 knockdown and miR-326 overexpression; 3D cultures; xenograft models; Western blot for FAK/Src; fibronectin coating | Breast cancer research and treatment | High | 35338412 |
| 2022 | Extracellular vesicle-packaged ITGA5 (together with CDH11) from breast cancer cells with high RUNX2 educates osteoblasts to form an osteogenic premetastatic niche; CDH11high/ITGA5high EVs promote bone colonization by RUNX2-high breast cancer cells. | In vitro and in vivo EV transfer experiments; osteoblast education assay; bone metastasis mouse model; EV proteomics | Cancer research | Medium | 35149589 |
| 2022 | Elevated ITGA5 is a downstream effector of hyperactivated mTORC1 in laryngeal squamous cell carcinoma; ITGA5 promotes LSCC progression through upregulation of ephrin-B2 (EFNB2), and inhibition of ITGA5 sensitizes cells to cisplatin in CDX and PDX models. | Raptor knockdown (mTORC1 inhibition); transcriptomic sequencing; ITGA5 functional assays; in vivo CDX and PDX models; Western blot | Theranostics | Medium | 36438491 |
| 2021 | NEAT1 lncRNA acts as a sponge for miR-128-3p in glioma, relieving miR-128-3p-mediated repression of ITGA5; elevated ITGA5 then activates the FAK signaling pathway to promote cell growth. | Luciferase reporter assay, RNA pull-down, RNA immunoprecipitation; CCK-8, transwell, flow cytometry in U87MG and U251MG cells; ITGA5 siRNA and NEAT1 overexpression/knockdown | Molecular neurobiology | Medium | 34263426 |
| 2021 | Leptin reduces ITGA5 expression in adipocytes, thereby inhibiting activation of the PI3K/AKT signaling pathway, alleviating adipose tissue fibrosis and promoting white fat browning; ITGA5 overexpression with wortmannin (PI3K inhibitor) treatment confirmed ITGA5 acts upstream of PI3K/AKT in fibrosis. | Leptin treatment; proteomics screening; ITGA5 overexpression and siRNA in adipocytes; TGF-β/HFD fibrosis model; qPCR, WB, IHC, immunofluorescence; wortmannin inhibitor | International journal of molecular sciences | Medium | 34830238 |
| 2023 | AFAP1L1 interacts with VAV2 guanine nucleotide exchange factor to activate Rho GTPase CDC42, which then promotes ITGA5 expression and integrin signaling pathway activation in gastric cancer, driving EMT and metastasis. | Co-immunoprecipitation; cell adhesion assay; in vitro and in vivo GC functional assays; ITGA5 expression analysis after AFAP1L1 manipulation | Journal of translational medicine | Medium | 36631800 |
| 2022 | FGA (fibrinogen α chain) transcriptionally suppresses ITGA5 expression (confirmed by luciferase and ChIP assays), leading to inhibition of the FAK/ERK pathway and suppression of gastric cancer cell motility, EMT, and autophagy. | Luciferase reporter and ChIP assays confirming FGA transcriptional regulation of ITGA5; Western blot for FAK/ERK; in vivo BALB/c xenograft model | Tissue & cell | Medium | 35257941 |
| 2022 | ITGA5 knockdown in LSCC cells inhibits expression and secretion of VEGF-C, suppresses lymphatic endothelial cell tube formation and LSCC cell migration/invasion; exogenous VEGF-C supplementation reverses these effects, placing ITGA5 upstream of VEGF-C in lymphangiogenesis. | siRNA knockdown of ITGA5; tube formation assay with HLECs; ELISA for VEGF-C; transwell co-culture; in vivo subcutaneous graft model | Protoplasma | Medium | 37338646 |
| 2023 | ACTN1 (α-Actinin 1) physically interacts with ITGA5 (confirmed by Co-IP) in HNSCC cells; ACTN1 depletion reduces proliferation, invasion, migration, and EMT, and these effects are reversed by ITGA5 overexpression, demonstrating ACTN1 acts through ITGA5. | Co-immunoprecipitation; CCK8, colony formation, EdU, transwell, wound healing assays; immunofluorescence; xenograft in nude mice; IHC for Ki-67 | Iranian journal of basic medical sciences | Medium | 36742137 |
| 2023 | FAPα and ITGA5 form a protein complex in the inflammatory microenvironment of chronic apical periodontitis; silencing either protein decreases osteoclast differentiation; molecular docking shows FAPα binds ITGA5 with -14.5 kcal/mol free energy. | Molecular docking; co-immunoprecipitation; immunofluorescence staining; FAPα/ITGA5 siRNA silencing; osteoclast differentiation assay | International journal of biological macromolecules | Medium | 37979759 |
| 2024 | METTL3 stabilizes HOXD8 mRNA in an m6A-dependent manner; HOXD8 then transcriptionally activates ITGA5 (confirmed by ChIP and luciferase), and elevated ITGA5 enhances osteogenic differentiation of CPT periosteum-derived MSCs. | MeRIP assay for m6A modification of HOXD8; luciferase reporter assay; ChIP assay; METTL3/HOXD8/ITGA5 overexpression; Alizarin Red S and ALP assays | Regenerative therapy | Medium | 38818480 |
| 2024 | FN1 secreted by dental pulp stem cells (DPSCs) promotes endothelial cell proliferation, migration, and tube formation via ITGA5 and downstream PI3K/AKT signaling pathway during dental pulp vascularization. | Co-culture of DPSCs and HUVECs; Western blot for FN1, ITGA5, PI3K/AKT; cell proliferation, scratch, and tube formation assays; siRNA knockdown; in vivo mouse experiments | Stem cell reviews and reports | Medium | 38418738 |
| 2024 | Itga5 interacts with PTEN in striatal neurons; Itga5 deficiency in MPTP-induced Parkinson's disease models reduces dendritic spine density, alters synaptic architecture, and impairs motor coordination through reduced AKT signaling; a TAT-Itga5 peptide designed to suppress PTEN activity rescues these deficits. | MPTP mouse model; CRISPR-CasRx knockdown; mass spectrometry; electrophysiology; Western blot; behavioral tests; immunostaining for spine morphology | International journal of biological sciences | Medium | 38993558 |
| 2024 | circSDHAF2 promotes N-glycosylation of ITGA5 protein, stabilizing it and facilitating its translocation into exosomes; exosomal ITGA5 is delivered to macrophages and induces SPP1+ MDM formation, which maintains mesenchymal GBM cell status and drives T-cell dysfunction via the SPP1-ITGA5 pathway, promoting immune escape. | Co-immunoprecipitation; RNA immunoprecipitation; pull-down assays; single-cell RNA sequencing; spatial transcriptomics; in vitro and in vivo validation | Cancer communications | Medium | 40084746 |
| 2024 | IGFBP2 promotes gefitinib resistance in NSCLC by activating STAT3/CXCL1 axis; ITGA5 is identified as a key player in IGFBP2-mediated resistance but does NOT function as a membrane receptor linking IGFBP2 to intracellular signaling transduction (negative finding for that specific mechanism). | In vitro and in vivo resistance experiments; IGFBP2/ITGA5 knockdown; Western blot for STAT3/CXCL1 | Cell death & disease | Low | 38918360 |
| 2023 | ITGA5+ synovial fibroblasts (POSTN+, COL3A1+, CCL5+, TGFB1+) are induced to differentiate by TGF-β1 and promote differentiation of naïve CD4+ T cells into CXCL13hiPD-1hi peripheral helper T cells via TGF-β1 secretion; intra-articular injection of ITGA5+ fibroblasts exacerbates collagen-induced arthritis and upregulates TPH cells in mice. | Single-cell and spatial transcriptomics; flow cytometry; co-culture assay; adoptive transfer in CIA mice; bulk RNA sequencing of synovial joints; multiplex immunofluorescence | Annals of the rheumatic diseases | Medium | 39919897 |
| 2024 | Myofibroblast-derived extracellular vesicles transfer ITGA5 protein to HCC cells; ITGA5 delivered to HCC cells directly binds YES1 kinase, activating YES1 and downstream pathways to enhance cancer stem cell-like properties; CRISPR KO of ITGA5 in myofibroblasts impairs this process. | CRISPR Cas9 KO; EV isolation and transfer; Co-IP/mass spectrometry; sphere-forming assay; stemness marker expression; orthotopic HCC mouse model; tissue microarray | Molecular cancer | High | 39574133 |
| 2025 | ITGA5 on tumor cells binds fibronectin (FN1) in the Schwann cell extracellular matrix, triggering reprogramming of Schwann cells to a reparative phenotype with enhanced NGF secretion; increased NGF suppresses NK cell cytotoxicity by inhibiting IFN-γ, promoting immune evasion and perineural invasion. | Functional assays for SC reprogramming; NGF secretion measurement; NK cell cytotoxicity assay; IFN-γ quantification; cilengitide (ITGA5 inhibitor) treatment with anti-PD-1 therapy | Molecular therapy | Medium | 40734271 |
| 2025 | 13-Methylpalmatine suppresses ITGA5 expression and inhibits activation of the TGF-β/Smad signaling pathway; ITGA5 silencing confirms ITGA5 acts upstream of TGF-β/Smad in pulmonary fibrosis, and ITGA5 overexpression reverses 13-Me-PLT's antifibrotic effect. | Transcriptomic sequencing; molecular docking and SPR for direct binding; ITGA5 silencing and overexpression in MRC5 cells; BLM mouse model; Smad pathway Western blot | Phytomedicine | Medium | 40023972 |
| 2023 | TLN1 (Talin-1) overexpression increases ITGA5 expression; ITGA5 knockdown reverses the protective effects of TLN1 on cardiac microvascular endothelial cells under ox-LDL injury, demonstrating TLN1 acts through ITGA5 to regulate CMVEC function. | TLN1 overexpression and ITGA5 siRNA knockdown in ox-LDL-treated CMVECs; proliferation, apoptosis, angiogenesis, inflammation, oxidative stress assays | Folia morphologica | Low | 37144848 |
| 2015 | In zebrafish, prdm1a acts upstream of itga5 in posterior pharyngeal arch development; prdm1a mutants show decreased itga5 expression, and injection of itga5 mRNA into prdm1a mutants rescues loss of posterior pharyngeal arch dlx2a expression, ceratobranchial cartilages 2-5, and cell proliferation. | In situ hybridization; double prdm1a;itga5 mutant analysis; mRNA rescue injection; cell proliferation assay | Genesis | Medium | 25810090 |
| 2025 | ITGA5 drives angiogenesis in diabetic retinopathy by activating the TAK-1/NF-κB signaling pathway; ITGA5 knockdown in vivo reduces neovascularization, decreases FAK, TAK-1, and p65 phosphorylation, and reduces VEGFA, VCAM-1, and ICAM-1 expression. | Streptozotocin-induced diabetic rat model; intravitreal AAV-mediated ITGA5 knockdown; oxygen-induced retinopathy model; Western blot for FAK/TAK-1/NF-κB; tube formation and invasion in high glucose-treated RRMECs | Human cell | Medium | 40410450 |
| 2025 | RPRD1A competes with RPAP2 for binding to RNA Pol II, derepressing ITGA5 transcription via a c-JUN-dependent pathway; upregulated ITGA5 then activates FAK signaling to drive lenvatinib resistance in HCC; combined lenvatinib with ITGA5 inhibitor (volociximab) or FAK inhibitor (defactinib) reverses resistance. | Functional resistance assays; Western blot; transcriptional mechanism assays (RPRD1A-RPAP2-RNA Pol II competition); ITGA5 inhibition and FAK inhibition in preclinical models | Molecular biomedicine | Medium | 42171939 |
| 2026 | DTX1 E3 ubiquitin ligase directly interacts with ITGA5 and promotes its ubiquitination at lysine 137, leading to proteasome-dependent degradation of ITGA5 and maintenance of the contractile VSMC phenotype; DTX1 overexpression reduces ITGA5 levels and attenuates aortic dissection progression in vivo. | Co-immunoprecipitation; protein stability analysis; ubiquitination site identification (K137); gain/loss-of-function in HASMCs; BAPN-induced AD mouse model; Western blot, qPCR, immunofluorescence | Cardiovascular drugs and therapy | Medium | 42090073 |
| 2025 | ITGA5 directly binds PI3K in vitro (confirmed by binding assay); ITGA5-mediated PI3K/AKT pathway activation promotes EMT and anoikis resistance in bronchial epithelial cells; ITGA5 knockdown reverses TGF-β1-induced EMT and restores anoikis sensitivity. | Quantitative proteomics; ITGA5 knockdown; Western blot for PI3K/AKT; EMT and anoikis assays; molecular docking and dynamics; in vitro PI3K binding assay; in vivo asthma mouse model | Cell proliferation | Medium | 41772919 |
| 2025 | MFAP5, an extracellular matrix component, engages ITGA5 to activate ERK/MAPK signaling in odontoblast-lineage cells, promoting odontoblast differentiation and dentin deposition during tooth mineralization. | 10× single-cell RNA sequencing; functional differentiation assays in vitro; ITGA5 and MFAP5 manipulation; Western blot for ERK/MAPK | International journal of molecular sciences | Low | 41516268 |
| 2026 | SPP1-ITGA5 interaction between SPP1+ macrophages and ITGA5+ fibroblasts in HCC triggers secretion of MMP2 by fibroblasts, promoting HCC malignant progression; confirmed by co-immunoprecipitation and cell co-culture assays with in vivo validation. | Co-immunoprecipitation; cell co-culture; in vivo mouse transplantation model; single-cell RNA sequencing; spatial transcriptomics; multiplexed immunofluorescence | Hepatology communications | Medium | 41758046 |
| 2025 | GBX2 transcription factor binds to the promoter region of ITGA5 and activates its transcription, upregulating ITGA5 expression in bladder cancer cells to promote viability, migration, and invasion. | Chromatin immunoprecipitation (ChIP); luciferase reporter assay for promoter binding; GBX2 knockdown and ITGA5 overexpression rescue experiments | Functional & integrative genomics | Medium | 35672622 |
| 2025 | ITGA5 promotes GBM cell invasion and migration through SLK (a downstream kinase of the PI3K-Akt pathway); ITGA5 knockdown reduces SLK expression and activity, and this mechanism was identified by proteomics and phosphoproteomics after ITGA5 knockdown. | Proteomics and phosphoproteomics after ITGA5 knockdown; in vitro invasion/migration assays; in vivo GBM model; Western blot; single-cell RNA sequencing | Neurological research | Medium | 40544320 |
| 2026 | CTHRC1 secreted by cancer-associated fibroblasts directly binds ITGA5 on tumor cells, activating the PI3K/AKT signaling pathway to promote proliferation, EMT, and angiogenesis in HNSCC. | Functional experiments in vitro and in vivo; protein binding confirmation; Western blot for PI3K/AKT; single-cell RNA sequencing; spatial transcriptomics | Cellular signalling | Medium | 41651176 |
| 2026 | ITGA5 interacts with IMP3 (insulin-like growth factor II mRNA binding protein 3), and this interaction regulates IMP3-mediated recruitment of HK2 mRNA, promoting the Warburg effect and cervical cancer progression; HK2 overexpression rescues the effects of ITGA5 knockdown. | Mass spectrometry (Co-IP/MS); Co-immunoprecipitation; RNA immunoprecipitation (RIP); Western blot; xenograft in nude mice; rescue experiment with HK2 overexpression | American journal of translational research | Medium | 40385029 |
| 2025 | Resibufogenin (RBG) activates the ITGA5-VEGF signaling axis in a macrophage-dependent manner to promote reparative angiogenesis in myocardial infarction; RBG upregulates ITGA5 in macrophages via the VAV3/CDC42 signaling pathway; pharmacological ITGA5 inhibition or macrophage depletion completely abolishes RBG-mediated cardioprotection. | Proteomic analysis; macrophage-endothelial co-culture; ITGA5 inhibition; macrophage depletion; MI mouse model; tube formation assay; Western blot for VAV3/CDC42/ITGA5/VEGF | Acta pharmacologica Sinica | Medium | 42056214 |
| 2023 | Nitric oxide (NO) prevents hypoxia-induced ITGA5 CpG promoter hypermethylation by DNMT1 in endothelial progenitor cells; hypoxia suppresses miR-148 levels, increasing DNMT1-mediated ITGA5 promoter methylation and reducing ITGA5 expression and cell-matrix adhesion; NO or miR-148 overexpression restores ITGA5 expression and adhesion. | miScript miRNA qPCR array; DNMT1 inhibitor (5'-azacitidine); miR-148 overexpression; eNOS-GFP transfection; hypoxia model in EPCs; cell-matrix adhesion assay | Biochemical and biophysical research communications | Medium | 36669384 |
| 2021 | HIF-1A and NFATC1 transcription factors regulate ITGA5 gene expression in intestinal epithelial cells under hypoxia; chemical activation of HIF signaling (cobalt chloride/oxyquinoline) upregulates ITGA5 expression in Caco-2 cells, confirmed by RNA sequencing and proteomics. | RNA sequencing and proteomics of HIF-activated Caco-2 cells; bioinformatic transcription factor analysis (miRGTF tool); validation in IBD patient RNA-seq datasets | Frontiers in genetics | Low | 34858489 |
| 1991 | ITGA5 (FNRA, fibronectin receptor alpha subunit) maps to chromosome 12 in humans, confirmed using human-rodent somatic cell hybrids and cDNA probes. | Somatic cell hybrid mapping with cDNA probes | Annals of human genetics | Low | 1722386 |
| 2020 | CD49e (ITGA5) on Burkitt lymphoma cells mediates cell adhesion-mediated drug resistance (CAM-DR) via NF-κB pathway activation, increasing Bcl-xL and survivin and decreasing Bax, Bim, and PUMA; bortezomib overcomes CAM-DR by inhibiting NF-κB. | CD49e blocking antibodies; NF-κB activity assay; Western blot for apoptosis proteins; bortezomib treatment; adhesion-based drug resistance assay | Journal of physiology and pharmacology | Medium | 33214335 |
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2012 | miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS, and CSF1. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology | 121 | 23233531 |
| 2019 | ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer. | Science advances | 103 | 31517053 |
| 2016 | ITGAV and ITGA5 diversely regulate proliferation and adipogenic differentiation of human adipose derived stem cells. | Scientific reports | 98 | 27363302 |
| 2024 | ZNF460-mediated circRPPH1 promotes TNBC progression through ITGA5-induced FAK/PI3K/AKT activation in a ceRNA manner. | Molecular cancer | 70 | 38355583 |
| 2001 | The alpha 4 beta 1 (very late antigen (VLA)-4, CD49d/CD29) and alpha 5 beta 1 (VLA-5, CD49e/CD29) integrins mediate beta 2 (CD11/CD18) integrin-independent neutrophil recruitment to endotoxin-induced lung inflammation. | Journal of immunology (Baltimore, Md. : 1950) | 68 | 11254723 |
| 2017 | miR-330-5p suppresses glioblastoma cell proliferation and invasiveness through targeting ITGA5. | Bioscience reports | 67 | 28336765 |
| 2022 | Extracellular Vesicle-Packaged CDH11 and ITGA5 Induce the Premetastatic Niche for Bone Colonization of Breast Cancer Cells. | Cancer research | 64 | 35149589 |
| 2012 | Relationship between the expression of the extracellular matrix genes SPARC, SPP1, FN1, ITGA5 and ITGAV and clinicopathological parameters of tumor progression and colorectal cancer dissemination. | Oncology | 60 | 23128103 |
| 2022 | Exosome-depleted MiR-148a-3p derived from Hepatic Stellate Cells Promotes Tumor Progression via ITGA5/PI3K/Akt Axis in Hepatocellular Carcinoma. | International journal of biological sciences | 54 | 35414782 |
| 2016 | MicroRNA-330-5p negatively regulates ITGA5 expression in human colorectal cancer. | Oncology reports | 52 | 27633518 |
| 1999 | MPC-1-CD49e- immature myeloma cells include CD45+ subpopulations that can proliferate in response to IL-6 in human myelomas. | British journal of haematology | 49 | 10233376 |
| 2016 | miR-17 inhibits ovarian cancer cell peritoneal metastasis by targeting ITGA5 and ITGB1. | Oncology reports | 47 | 27499367 |
| 2019 | Integrin α5/ITGA5 Promotes The Proliferation, Migration, Invasion And Progression Of Oral Squamous Carcinoma By Epithelial-Mesenchymal Transition. | Cancer management and research | 44 | 32009816 |
| 2022 | Targeting HIF1-alpha/miR-326/ITGA5 axis potentiates chemotherapy response in triple-negative breast cancer. | Breast cancer research and treatment | 43 | 35338412 |
| 1998 | Adhesion molecule mechanisms mediating monocyte migration through synovial fibroblast and endothelium barriers: role for CD11/CD18, very late antigen-4 (CD49d/CD29), very late antigen-5 (CD49e/CD29), and vascular cell adhesion molecule-1 (CD106). | Journal of immunology (Baltimore, Md. : 1950) | 43 | 9552005 |
| 2019 | MicroRNA-328-3p inhibits the tumorigenesis of bladder cancer through targeting ITGA5 and inactivating PI3K/AKT pathway. | European review for medical and pharmacological sciences | 41 | 31298367 |
| 2019 | O-GlcNAcylation of ITGA5 facilitates the occurrence and development of colorectal cancer. | Experimental cell research | 40 | 31202709 |
| 2023 | ITGA5 promotes tumor angiogenesis in cervical cancer. | Cancer medicine | 39 | 36999964 |
| 2018 | Myocardin-Related Transcription Factor A Promotes Recruitment of ITGA5+ Profibrotic Progenitors during Obesity-Induced Adipose Tissue Fibrosis. | Cell reports | 38 | 29768198 |
| 2019 | Inhibition of microRNA-92a ameliorates lipopolysaccharide-induced endothelial barrier dysfunction by targeting ITGA5 through the PI3K/Akt signaling pathway in human pulmonary microvascular endothelial cells. | International immunopharmacology | 37 | 31841757 |
| 2022 | ITGA5 Is a Novel Oncogenic Biomarker and Correlates With Tumor Immune Microenvironment in Gliomas. | Frontiers in oncology | 36 | 35371978 |
| 2011 | Alcohol promotes breast cancer cell invasion by regulating the Nm23-ITGA5 pathway. | Journal of experimental & clinical cancer research : CR | 35 | 21838876 |
| 2022 | Elevated ITGA5 facilitates hyperactivated mTORC1-mediated progression of laryngeal squamous cell carcinoma via upregulation of EFNB2. | Theranostics | 32 | 36438491 |
| 2015 | miR-128 modulates hepatocellular carcinoma by inhibition of ITGA2 and ITGA5 expression. | American journal of translational research | 31 | 26550456 |
| 2005 | Expression of alpha5 integrin (Itga5) is elevated in the rat myometrium during late pregnancy and labor: implications for development of a mechanical syncytium. | Biology of reproduction | 31 | 15635129 |
| 2022 | ITGA5 and ITGB1 contribute to Sorafenib resistance by promoting vasculogenic mimicry formation in hepatocellular carcinoma. | Cancer medicine | 28 | 35946175 |
| 2022 | ITGA5 Promotes Tumor Progression through the Activation of the FAK/AKT Signaling Pathway in Human Gastric Cancer. | Oxidative medicine and cellular longevity | 27 | 36193075 |
| 2021 | LncRNA NEAT1 Enhances Glioma Progression via Regulating the miR-128-3p/ITGA5 Axis. | Molecular neurobiology | 25 | 34263426 |
| 2024 | Mesenchymal stem cell-derived extracellular vesicles exert pro-angiogenic and pro-lymphangiogenic effects in ischemic tissues by transferring various microRNAs and proteins including ITGa5 and NRP1. | Journal of nanobiotechnology | 24 | 38347587 |
| 2017 | Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association | 24 | 28689917 |
| 2017 | FN1, FOS, and ITGA5 induce preeclampsia: Abnormal expression and methylation. | Hypertension in pregnancy | 24 | 29039998 |
| 2025 | Blocking ITGA5 potentiates the efficacy of anti-PD-1 therapy on glioblastoma by remodeling tumor-associated macrophages. | Cancer communications (London, England) | 23 | 40084746 |
| 2024 | IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer. | Cell death & disease | 22 | 38918360 |
| 2021 | ITGA5 Predicts Dual-Drug Resistance to Temozolomide and Bevacizumab in Glioma. | Frontiers in oncology | 22 | 34976814 |
| 2024 | Myofibroblast-derived extracellular vesicles facilitate cancer stemness of hepatocellular carcinoma via transferring ITGA5 to tumor cells. | Molecular cancer | 21 | 39574133 |
| 2021 | HIF-Dependent NFATC1 Activation Upregulates ITGA5 and PLAUR in Intestinal Epithelium in Inflammatory Bowel Disease. | Frontiers in genetics | 21 | 34858489 |
| 2010 | Functional elucidation and methylation-mediated downregulation of ITGA5 gene in breast cancer cell line MDA-MB-468. | Journal of cellular biochemistry | 21 | 20564209 |
| 2010 | RNA interference-mediated knockdown of CD49e (α5 integrin chain) in human thymic epithelial cells modulates the expression of multiple genes and decreases thymocyte adhesion. | BMC genomics | 21 | 21210968 |
| 2025 | ITGA5+ synovial fibroblasts orchestrate proinflammatory niche formation by remodelling the local immune microenvironment in rheumatoid arthritis. | Annals of the rheumatic diseases | 19 | 39919897 |
| 2023 | AFAP1L1 promotes gastric cancer progression by interacting with VAV2 to facilitate CDC42-mediated activation of ITGA5 signaling pathway. | Journal of translational medicine | 19 | 36631800 |
| 2020 | MicroRNA-26a inhibits wound healing through decreased keratinocytes migration by regulating ITGA5 through PI3K/AKT signaling pathway. | Bioscience reports | 18 | 32955094 |
| 2022 | FGA inhibits metastases and induces autophagic cell death in gastric cancer via inhibiting ITGA5 to regulate the FAK/ERK pathway. | Tissue & cell | 17 | 35257941 |
| 2021 | The Mechanism of Leptin on Inhibiting Fibrosis and Promoting Browning of White Fat by Reducing ITGA5 in Mice. | International journal of molecular sciences | 17 | 34830238 |
| 2020 | miR-27b Suppresses Tongue Squamous Cell Carcinoma Epithelial-Mesenchymal Transition by Targeting ITGA5. | OncoTargets and therapy | 17 | 33239888 |
| 2003 | Anaerobic regulation of Actinobacillus actinomycetemcomitans leukotoxin transcription is ArcA/FnrA-independent and requires a novel promoter element. | Research in microbiology | 17 | 14596902 |
| 2023 | ACTN1 interacts with ITGA5 to promote cell proliferation, invasion and epithelial-mesenchymal transformation in head and neck squamous cell carcinoma. | Iranian journal of basic medical sciences | 16 | 36742137 |
| 2020 | Evaluation of CD49e as a distinguishing marker for human articular cartilage derived chondroprogenitors. | The Knee | 15 | 32317141 |
| 2023 | The members of the miR-148/152 family inhibit cancer stem cell-like properties in gastric cancer via negative regulation of ITGA5. | Journal of translational medicine | 13 | 36765401 |
| 2024 | Enhancing Vasculogenesis in Dental Pulp Development: DPSCs-ECs Communication via FN1-ITGA5 Signaling. | Stem cell reviews and reports | 12 | 38418738 |
| 2020 | Integrin Subunit Alpha 5 (ITGA5) Gene Circular RNA Sponges microRNA-107 in Colorectal Carcinoma Cells and Tissues and Regulates the Expression of the Forkhead Box J3 (FOXJ3) Gene. | Medical science monitor : international medical journal of experimental and clinical research | 12 | 32305992 |
| 2015 | Effect of ITGA5 down-regulation on the migration capacity of human dental pulp stem cells. | International journal of clinical and experimental pathology | 12 | 26823759 |
| 1995 | The capacity of human malignant B-lymphocytes to disseminate in SCID mice is correlated with functional expression of the fibronectin receptor alpha 5 beta 1 (CD49e/CD29). | International journal of cancer | 12 | 7534750 |
| 2020 | The clinical significance of CD49e and CD56 for multiple myeloma in the novel agents era. | Medical oncology (Northwood, London, England) | 10 | 33068194 |
| 2013 | Significance of expression of ITGA5 and its splice variants in acute myeloid leukemia: a report from the Children's Oncology Group. | American journal of hematology | 9 | 23686445 |
| 2003 | Expression of CD18, CD49b, CD49c and CD49e on lens anterior capsules in human cataracts. | Eye (London, England) | 9 | 12802345 |
| 1998 | Expression of alpha5 (CD49e) and alpha6 (CD49f) integrin subunits on T cells in the circulation and the lamina propria of normal and inflammatory bowel disease colonic mucosa. | Scandinavian journal of immunology | 9 | 9790314 |
| 2022 | Oncogenic GBX2 promotes the malignant behaviors of bladder cancer cells by binding to the ITGA5 promoter and activating its transcription. | Functional & integrative genomics | 8 | 35672622 |
| 2021 | LncRNA EWSAT1 Regulates the Tumorigenesis of NSCLC as a ceRNA by Modulating miR-330-5p/ITGA5 Axis. | Biochemical genetics | 8 | 33928467 |
| 1999 | Expression of the adhesion molecules CD49d and CD49e on G-CSF-mobilized CD34+ cells of patients with solid tumors or non-Hodgkin's and Hodgkin's lymphoma and of healthy donors is inversely correlated with the amount of mobilized CD34+ cells. | Journal of hematotherapy & stem cell research | 8 | 10791904 |
| 2025 | 13-Methylpalmatine alleviates bleomycin-induced pulmonary fibrosis by suppressing the ITGA5/TGF-β/Smad signaling pathway. | Phytomedicine : international journal of phytotherapy and phytopharmacology | 7 | 40023972 |
| 2025 | ITGA5-expressing tumor cells interact with Schwann cells to drive nerve growth factor-mediated immunosuppression of NK cells. | Molecular therapy : the journal of the American Society of Gene Therapy | 7 | 40734271 |
| 2023 | TLN1 synergizes with ITGA5 to ameliorate cardiac microvascular endothelial cell dysfunction. | Folia morphologica | 7 | 37144848 |
| 2015 | prdm1a functions upstream of itga5 in zebrafish craniofacial development. | Genesis (New York, N.Y. : 2000) | 7 | 25810090 |
| 2023 | The novel protein complex FAPα/ITGA5 is involved in the bone destruction of apical periodontitis. | International journal of biological macromolecules | 6 | 37979759 |
| 2018 | Down regulation of ITGA4 and ITGA5 genes after formation of 3D spherules by human Wharton's jelly stem cells (hWJSCs). | Molecular biology reports | 6 | 29411210 |
| 1992 | Assignment of three rat integrin genes to chromosome 19 (ITGB1), chromosome 3 (ITGA4), and chromosome 7 (ITGA5). | Mammalian genome : official journal of the International Mammalian Genome Society | 6 | 1477477 |
| 2024 | METTL3 promotes the osteogenic differentiation of periosteum-derived MSCs via regulation of the HOXD8/ITGA5 axis in congenital pseudarthrosis. | Regenerative therapy | 5 | 38818480 |
| 2024 | Systematic multiomics analysis and in vitro experiments suggest that ITGA5 could serve as a promising therapeutic target for ccRCC. | Cancer cell international | 5 | 39501306 |
| 2020 | CD49d and CD49e induce cell adhesion-mediated drug resistance through the nuclear factor-κB pathway in Burkitt lymphoma. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society | 5 | 33214335 |
| 2025 | ITGA5 induces mesenchymal transformation to promote gliomas progression via PI3K/AKT/mTORC1 signaling pathway. | Scientific reports | 4 | 40253517 |
| 2024 | A Continuous Extension of Gene Set Enrichment Analysis Using the Likelihood Ratio Test Statistics Identifies Vascular Endothelial Growth Factor as a Candidate Pathway for Alzheimer's Disease via ITGA5. | Journal of Alzheimer's disease : JAD | 4 | 38160360 |
| 2024 | Itga5-PTEN signaling regulates striatal synaptic strength and motor coordination in Parkinson's disease. | International journal of biological sciences | 4 | 38993558 |
| 2023 | Nitric oxide promotes cell-matrix adhesion of endothelial progenitor cells under hypoxia condition via ITGA5 CpG promoter demethylation. | Biochemical and biophysical research communications | 4 | 36669384 |
| 2024 | CircRSU1 alleviates LPS-induced human pulmonary microvascular endothelial cell injury by targeting miR-1224-5p/ITGA5 axis. | General physiology and biophysics | 3 | 38312030 |
| 2024 | hsa_circ_0000518 stimulates the malignant progression of hepatocellular carcinoma via regulating ITGA5 to activate the Warburg effect. | Cellular signalling | 3 | 38830562 |
| 2016 | miR-128 modulates hepatocellular carcinoma by inhibition of ITGA2 and ITGA5 expression [Retraction]. | American journal of translational research | 3 | 27186316 |
| 2025 | ITGA5 promotes cervical cancer progression by regulating IMP3 recruitment of HK2 mRNA. | American journal of translational research | 2 | 40385029 |
| 2025 | ITGA5 drives angiogenesis in diabetic retinopathy via TAK-1/NF-kB activation. | Human cell | 2 | 40410450 |
| 2025 | Inflammation-related gene ITGA5 affects the healing of diabetic foot ulcers through PI3K-AKT signaling pathway. | European journal of pharmacology | 2 | 40555342 |
| 2025 | Triptolide targets PPP2CA/ITGA5 axis to suppress lactate-driven ovarian cancer progression. | Chinese medicine | 2 | 40770810 |
| 1991 | Confirmation of the assignment of the vitronectin (VNRA) and fibronectin (FNRA) receptor alpha-subunits. | Annals of human genetics | 2 | 1722386 |
| 2026 | Crosstalk between SPP1+ macrophages and ITGA5+ fibroblasts promotes hepatocellular carcinoma metastasis. | Hepatology communications | 1 | 41758046 |
| 2025 | Single-cell and bulk transcriptomic analyses reveal ITGA5-driven epithelial-mesenchymal transition and metabolic adaptation in thyroid cancer. | Biochemical and biophysical research communications | 1 | 40992268 |
| 2025 | Spatially resolved endothelial signaling via nampt-itga5 drives immune evasion in stem-like gastric cancer. | Cancer immunology, immunotherapy : CII | 1 | 41021026 |
| 2025 | Polyethylene microplastics trigger osteosarcoma progression via ITGA5/FAPα/LGMN cancer promoting complex: A novel environmental cancer promoting mechanism. | Ecotoxicology and environmental safety | 1 | 41086694 |
| 2025 | Adipocytes promoted anoikis resistance of head and neck cancer cells via overexpressed ITGA5. | European journal of medical research | 1 | 41108014 |
| 2025 | Engineered cyclic peptide targeting ITGA5 disrupts tumor-stroma interaction to overcome desmoplasia and resistance in pancreatic ductal adenocarcinoma. | Acta pharmaceutica Sinica. B | 1 | 41584360 |
| 2023 | Downregulation of ITGA5 inhibits lymphangiogenesis and cell migration and invasion in male laryngeal squamous cell carcinoma. | Protoplasma | 1 | 37338646 |
| 2026 | Multi-omics reveals that CTHRC1 secreted by cancer-associated fibroblasts promotes EMT by ITGA5/PI3K/AKT signaling pathway in HNSCC. | Cellular signalling | 0 | 41651176 |
| 2026 | Mechanism of action of MiR-330-5p targeting ITGA5 in the regulation of proliferation, migration, and invasionof gastric cancer. | BMC cancer | 0 | 41673591 |
| 2026 | ITGA5 as a Dual Regulator of Epithelial-Mesenchymal Transition and Epithelial Cell Anoikis Resistance: Functional Validation and Drug Prediction. | Cell proliferation | 0 | 41772919 |
| 2026 | Resibufogenin promotes angiogenesis via the VAV3-mediated ITGA5-VEGF signaling axis in macrophages to alleviate myocardial infarction. | Acta pharmacologica Sinica | 0 | 42056214 |
| 2026 | DTX1 Regulates Aortic Dissection Progression by Modulating Vascular Smooth Muscle Cell Phenotypic Switching via Ubiquitination of ITGA5. | Cardiovascular drugs and therapy | 0 | 42090073 |
| 2026 | RPRD1A drives lenvatinib resistance in hepatocellular carcinoma via the ITGA5-FAK signaling axis. | Molecular biomedicine | 0 | 42171939 |
| 2026 | Bioinformatic and experimental analysis reveals ITGA5 as a driver of ovarian clear cell carcinoma progression and platinum resistance. | 3 Biotech | 0 | 42179928 |
| 2026 | ITGA5 is overexpressed and promotes tumor progression through SNAI2 in OSCC. | Frontiers in cell and developmental biology | 0 | 42255482 |
| 2025 | ITGA5 drives glioblastoma progression through SLK-mediated activation of the PI3K-Akt pathway. | Neurological research | 0 | 40544320 |
| 2025 | Thermoradiotherapy reverses proliferation, metastasis, and anoikis resistance in glioblastoma through ITGA5-PI3K/AKT axis. | Translational oncology | 0 | 41056688 |
| 2025 | Synergistic targeting of ITGA5/CCN1 by Sparganii Rhizoma and Curcumae Rhizoma suppresses breast cancer metastasis via angiogenesis and adhesion. | Phytomedicine : international journal of phytotherapy and phytopharmacology | 0 | 41135273 |
| 2025 | MFAP5 Activates ITGA5 to Drive Tooth Germ Mineralization Through the MAPK/ERK Pathway: Insights from Single-Cell Transcriptomics. | International journal of molecular sciences | 0 | 41516268 |
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