Affinage

MAG

Myelin-associated glycoprotein · UniProt P20916

Length
626 aa
Mass
69.1 kDa
Annotated
2026-06-10
100 papers in source corpus 24 papers cited in narrative 24 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/9 claims corpus-supported (89%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MAG (myelin-associated glycoprotein/Siglec-4a) is a periaxonal Ig-superfamily glycoprotein that couples glial myelin to axons and bidirectionally regulates axon growth, stability, and survival (PMID:2430983, PMID:20484625). It localizes specifically to axon–glial apposition sites, Schmidt-Lanterman incisures, mesaxons, and paranodal loops but is excluded from compact myelin (PMID:2430983), partitioning into cholesterol-dependent lipid rafts after trans-Golgi glycosylation and engaging neuronal raft fractions containing its receptors (PMID:12691736). On the neuronal side, MAG—including a soluble shed ectodomain (dMAG)—acts as a true inhibitory ligand that collapses growth cones and blocks neurite outgrowth (PMID:9361272), signaling through a receptor complex of NgR1, the p75 neurotrophin receptor, and the endocytic receptor LRP1, with gangliosides GD1a/GT1b serving as sialic-acid-bearing functional ligands (PMID:12422217, PMID:12060784, PMID:23132925). MAG binding triggers PKC-dependent regulated intramembrane proteolysis of p75NTR (sequential α- and γ-secretase cleavage) required for RhoA activation, with CRMP4 acting as the downstream effector of both growth inhibition and axon protection (PMID:15953414, PMID:22583768); the same pathway can drive p75NTR/JNK-dependent apoptosis of developing cerebellar granule neurons (PMID:31570696). Neurotrophin signaling reverses MAG inhibition via a CaMKIV→CREB arm acting in parallel with PKA (PMID:18381242). On the glial side, MAG maintains long-term axon–myelin integrity and normal axonal caliber: Mag-null myelin develops pathological outfoldings and enlarged axons (PMID:36354016), and MAG is required for axon–myelin attachment, a role compensated in part by N-CAM and relevant in the CMT1A/PMP22 context (PMID:9011400, PMID:22940629). MAG membrane anchoring and stability depend on sulfatide and on complex gangliosides, the latter maintaining MAG protein post-transcriptionally (PMID:24081651, PMID:15175257). Its L-MAG and S-MAG isoforms, generated by hnRNP A1/U1 snRNP-regulated alternative splicing of exon 12, show distinct subcellular distributions, with L-MAG subject to tyrosine-motif-directed endocytosis (PMID:23704325, PMID:16442810, PMID:8557747). A homozygous p.Arg118His mutation in the sialic-acid-binding Ig domain 1 of MAG causes a human demyelinating leukodystrophy (PMID:27606346).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1986 High

    Establishing where MAG resides was the prerequisite to assigning function; immunoEM placed it precisely at axon–glial interfaces and excluded it from compact myelin, defining it as a periaxonal contact molecule distinct from structural myelin proteins.

    Evidence Pre- and post-embedding immunoelectron microscopy across developmental time points

    PMID:2430983

    Open questions at the time
    • Does not identify binding partners on the axon
    • Functional consequence of periaxonal localization untested
  2. 1997 Medium

    It was unclear whether MAG actively signals inhibition or merely fails to support growth; soluble dMAG inhibiting outgrowth, neutralizable by immunodepletion or antibody, established MAG as a true receptor-engaging inhibitory ligand.

    Evidence Soluble MAG-Fc neurite outgrowth and growth cone collapse assays with immunodepletion and antibody block

    PMID:9361272

    Open questions at the time
    • Neuronal receptor not identified in this study
    • Downstream signaling undefined
  3. 1999 Medium

    To find the neuronal receptor, MAG-Fc pulldowns identified sialic-acid-dependent neuronal surface sialoglycoproteins (~190/250 kDa), framing MAG as a sialic-acid-binding receptor with defined but unidentified partners.

    Evidence MAG-Fc pulldown across cerebellar, DRG, and PC12 neurons with desialylation and antibody controls

    PMID:10494110

    Open questions at the time
    • Co-precipitated proteins not molecularly identified
    • Direct vs indirect binding not resolved
  4. 2002 High

    The signaling receptor complex and the sialylated ligand were defined: p75NTR is an obligate co-receptor with NgR, and gangliosides GD1a/GT1b are functional sialic-acid ligands, unifying the receptor and glycan arms of MAG signaling.

    Evidence Co-IP, p75 knockout neurons, dominant-negative p75 (NgR); neuraminidase, ganglioside biosynthesis/genetic modification, antiganglioside antibodies, multivalent clustering

    PMID:12060784 PMID:12422217

    Open questions at the time
    • How NgR-glycan and p75 inputs are integrated unresolved
    • Transmembrane signaling step not yet defined
  5. 2003 Medium

    The physical interface of signaling was addressed: MAG partitions into cholesterol-dependent lipid rafts and engages neuronal raft fractions containing GT1b and NgR, framing a raft-to-raft signaling platform.

    Evidence Detergent-resistant membrane fractionation, cholesterol depletion, recombinant MAG raft-binding assay

    PMID:12691736

    Open questions at the time
    • No reconstitution or structural validation
    • Raft requirement for downstream signaling not functionally tested
  6. 2005 High

    How receptor engagement converts to intracellular signaling was answered: MAG triggers PKC-dependent sequential α/γ-secretase cleavage of p75NTR that is required for RhoA activation and growth inhibition.

    Evidence Biochemical cleavage assay in primary neurons with PKC and secretase inhibitors, RhoA and outgrowth readouts

    PMID:15953414

    Open questions at the time
    • Identity of activating PKC isoform unspecified
    • Link between cleaved p75 fragment and RhoA GEF unresolved
  7. 2008 Medium

    The mechanism of pharmacological reversal of MAG inhibition was clarified: a CaMKIV→CREB arm, dependent on intracellular calcium and parallel to PKA, is required for neurotrophins to overcome MAG inhibition.

    Evidence Pharmacological and dominant-negative CaMKIV, calcium chelation, cAMP/PKA manipulation, outgrowth assays

    PMID:18381242

    Open questions at the time
    • Direct CaMKIV substrates in this context not defined
    • Crosstalk point with RhoA pathway unmapped
  8. 2010 High

    Two outstanding questions—physiological in vivo relevance and a protective role—were addressed: MAG synergizes with Nogo-A/OMgp to restrict regeneration in vivo, and separately protects axons from toxic degeneration via ganglioside→RhoA/ROCK signaling independent of NgR/p75 cleavage.

    Evidence Single/double/triple knockout mice with spinal cord injury and behavior; myelin-substrate protection assay with sialidase, biosynthesis inhibitor, PI-PLC, p75 peptide, ROCK inhibitor

    PMID:20436925 PMID:20484625

    Open questions at the time
    • Why protection bypasses NgR/p75 but inhibition requires them is unresolved
    • Receptor mediating ganglioside-only protective signaling unidentified
  9. 2012 High

    The receptor complex and intracellular effector were extended: LRP1 is a high-affinity sialic-acid-independent endocytic MAG receptor associating with p75NTR, and CRMP4 is the shared downstream effector of MAG inhibition, collapse, and protection.

    Evidence RAP/RNAi/LRP1-KO loss of function, domain-mapping Fc-fusion binding, Co-IP, RhoA assay; CRMP4-KO DRG outgrowth, collapse, and vincristine protection assays

    PMID:22583768 PMID:23132925

    Open questions at the time
    • Stoichiometry of NgR/p75/LRP1/ganglioside complex unknown
    • How one CRMP4 node bifurcates into inhibition vs protection unresolved
  10. 2019 Medium

    A developmental fate decision was assigned to MAG signaling: MAG drives p75NTR-dependent JNK-mediated apoptosis of cerebellar granule neurons, with p75 deletion reducing developmental cell death in vivo.

    Evidence p75NTR-knockout in vivo, cerebellar apoptosis and JNK pathway analysis, outgrowth assays

    PMID:31570696

    Open questions at the time
    • Determinants selecting apoptosis vs growth inhibition output undefined
    • Requirement for LRP1/gangliosides in this death pathway untested
  11. 2007 Medium

    A non-neural function was identified: MAG (Siglec-4a) acts as a counter-receptor for sialyl-T MUC1, mediating sialidase-sensitive heterotypic adhesion between pancreatic cancer cells and Schwann cells.

    Evidence Heterotypic adhesion assay, Co-IP, sialidase sensitivity, antibody inhibition, overexpression

    PMID:17974963

    Open questions at the time
    • In vivo relevance to perineural invasion untested
    • Downstream signaling from MAG–MUC1 adhesion undefined
  12. 1986 Medium

    Glial-side maintenance functions and the structural basis of MAG anchoring and isoform control were progressively defined, establishing MAG's role in long-term axon–myelin integrity and caliber.

    Evidence Galgt1-KO ganglioside-dependent protein stability; MAG/N-CAM double KO and CMT1A/MAG-KO epistasis; sulfatide-dependent membrane anchoring; FIB-SEM of Mag-null myelin; hnRNP A1/U1 splicing of exon 12; GFP-S-MAG localization; L-MAG tyrosine-motif endocytosis

    PMID:15175257 PMID:16442810 PMID:22940629 PMID:23704325 PMID:24081651 PMID:36354016 PMID:8557747 PMID:9011400

    Open questions at the time
    • Molecular link between glial binding and axonal caliber control unclear
    • Functional division of labor between L-MAG and S-MAG not fully resolved
  13. 2016 Low

    Human relevance of MAG's sialic-acid-binding activity was established: a homozygous p.Arg118His mutation in Ig domain 1 causes a demyelinating leukodystrophy.

    Evidence Exome sequencing, clinical characterization, structural annotation of the sialic-acid binding site

    PMID:27606346

    Open questions at the time
    • No direct biochemical reconstitution of the binding defect
    • Single family; genotype–phenotype scope limited

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a single ligand–receptor system selects among opposing outputs—growth inhibition, axon protection, and apoptosis—and how the NgR/p75/LRP1/ganglioside inputs assemble into a defined signaling complex remains unresolved.
  • No structural model of the receptor complex
  • Switch determining inhibitory vs protective vs apoptotic signaling unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008289 lipid binding 3 GO:0060089 molecular transducer activity 3 GO:0098631 cell adhesion mediator activity 3
Localization
GO:0005886 plasma membrane 3 GO:0005768 endosome 2
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-162582 Signal Transduction 3 R-HSA-5357801 Programmed Cell Death 1
Partners
CRMP4GPR37LRP1MUC1NCAM1NGFRRTN4R
Complex memberships
NgR1–p75NTR–LRP1 MAG receptor complex

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 p75 neurotrophin receptor specifically interacts with NgR (Nogo receptor) and is required as a co-receptor for NgR-mediated inhibitory signaling by MAG, Nogo-66, and OMgp; neurons from p75 knockout mice are no longer responsive to these myelin inhibitors, and a truncated p75 lacking the intracellular domain attenuates inhibitory activity when overexpressed in primary neurons. Co-immunoprecipitation, knockout neurons, dominant-negative overexpression, neurite outgrowth assay Nature High 12422217
2002 Nerve cell surface gangliosides GD1a and GT1b are functional ligands for MAG-mediated inhibition of neurite outgrowth from primary rat cerebellar granule neurons; inhibition is attenuated by neuraminidase treatment, blocking ganglioside biosynthesis, genetic modification of terminal ganglioside structures, or antiganglioside antibodies, and is mimicked by multivalent clustering of GD1a or GT1b. Neurite outgrowth inhibition assay, neuraminidase treatment, pharmacological biosynthesis inhibition, genetic mouse model (modified ganglioside structures), antiganglioside monoclonal antibodies Proceedings of the National Academy of Sciences of the United States of America High 12060784
2005 MAG binding to cerebellar neurons induces sequential alpha- and gamma-secretase proteolytic cleavage of the p75 neurotrophin receptor in a protein kinase C (PKC)-dependent manner; this cleavage is necessary for both RhoA activation and inhibition of neurite outgrowth. Biochemical cleavage assay in primary neurons, PKC inhibitors/activators, secretase inhibitors, RhoA activation assay, neurite outgrowth assay Neuron High 15953414
2003 MAG is exclusively localized in low-buoyancy Lubrol WX-insoluble lipid raft membrane fractions in brain, primary oligodendrocytes, and MAG-expressing CHO cells; this lipid raft association depends on cellular cholesterol and occurs following terminal glycosylation in the trans-Golgi network. Recombinant MAG specifically interacts with lipid-raft fractions from neurons that contain MAG receptors GT1b and NgR, suggesting a lipid-raft-to-lipid-raft interaction mediates the MAG–neuron signaling interface. Detergent-resistant membrane fractionation, cholesterol depletion, subcellular fractionation, recombinant MAG binding assay Molecular and cellular neurosciences Medium 12691736
2012 LRP1 (LDL receptor-related protein-1) is a high-affinity, sialic-acid-independent endocytic receptor for MAG on neurons; functional inactivation of LRP1 (by receptor-associated protein, RNAi, or gene deletion) significantly reverses MAG- and myelin-mediated inhibition of neurite outgrowth. LRP1 and p75NTR associate in a MAG-dependent manner and MAG-mediated RhoA activation involves both LRP1 and p75NTR. LRP1 complement-like repeat clusters CII and CIV are the MAG-binding domains. Receptor-associated protein inhibition, RNAi knockdown, genetic deletion (LRP1 knockout), Co-IP, RhoA activation assay, neurite outgrowth assay, Fc-fusion protein binding Journal of cell science High 23132925
1997 Soluble MAG (extracellular domain, dMAG), released from myelin and detectable in vivo, potently inhibits axonal regeneration in a dose-dependent manner when presented in solution; this inhibition is completely neutralized by immunodepletion of dMAG or inclusion of a MAG antibody, demonstrating that MAG acts as a true inhibitory molecule (not merely non-permissive) by binding to a specific neuronal receptor and initiating signal transduction. Soluble chimeric MAG-Fc assay, neurite outgrowth inhibition, immunodepletion, antibody neutralization, growth cone collapse assay Molecular and cellular neurosciences Medium 9361272
1999 MAG-Fc chimera specifically precipitates several neuronal surface proteins from postnatal cerebellar, DRG, and PC12 neurons in a sialic acid-dependent manner; prominent proteins of ~190 kDa and ~250 kDa are co-precipitated from all three neuron types, and the 190 kDa protein is a sialoglycoprotein. Inhibition by a MAG antibody prevents precipitation, indicating specific receptor interactions. Chimeric MAG-Fc pulldown from neuronal cell surface proteins, competitive antibody inhibition, desialylation controls Journal of neuroscience research Medium 10494110
2008 CaMKIV is necessary for neurotrophin-induced phosphorylation of CREB and blockade of MAG-mediated inhibition of axonal growth; pharmacological inhibition or dominant-negative CaMKIV blocks the neurotrophin effect. CaMKIV activation requires calcium flux from intracellular stores and acts in parallel with PKA to overcome MAG inhibition. Pharmacological inhibition, dominant-negative overexpression, calcium chelation, cAMP/PKA manipulation, neurite outgrowth assay Molecular and cellular neurosciences Medium 18381242
2010 MAG and OMgp synergize with Nogo-A to inhibit axonal growth in vivo; myelin lacking only MAG and OMgp is indistinguishable from control in inhibitory activity, but myelin lacking all three inhibitors is less inhibitory than Nogo-A-deficient myelin alone, revealing redundant and synergistic roles. In vivo spinal cord injury studies showed that triple knockout of Nogo-A/MAG/OMgp produces greater axonal growth and locomotor recovery than Nogo-A single knockout. Genetic knockout mice (single, double, triple mutants), myelin inhibition assay, spinal cord injury model, behavioral assessment, axonal tracing The Journal of neuroscience High 20484625
2012 CRMP4 mediates MAG-induced inhibition of axonal outgrowth and growth cone collapse; loss of CRMP4 (CRMP4−/− neurons) prevents MAG-induced inhibition and growth cone collapse. CRMP4 is also required for MAG-mediated axonal protection against vincristine-induced degeneration, placing CRMP4 as a downstream effector of MAG/RhoA signaling for both inhibitory and protective functions. CRMP4 knockout mouse DRG neurons, MAG-induced neurite outgrowth inhibition assay, growth cone collapse assay, vincristine-induced axonal degeneration assay Neuroscience letters Medium 22583768
2010 MAG protects neurons from acute toxic insult (vincristine-induced neurite degeneration) via a ganglioside-mediated signaling pathway involving RhoA activation; protection is reversed by anti-MAG antibody, sialidase treatment, or glycosphingolipid biosynthesis inhibitor, but not by cleavage of NgR (via PI-PLC) or peptide inhibitor of p75NTR. ROCK inhibition also reverses protection, identifying RhoA/ROCK as the protective downstream effector. Myelin substrate culture, anti-MAG antibody, sialidase, biosynthesis inhibition, PI-PLC treatment, p75NTR inhibitor, ROCK inhibitor, Mag-null myelin ACS chemical neuroscience Medium 20436925
2019 MAG induces apoptosis in developing cerebellar granule neurons through p75NTR-mediated JNK/cell death signaling pathway; deletion of p75NTR in vivo reduces the number of apoptotic neurons in cerebellar white matter during development. MAG-induced apoptosis also impairs neurite outgrowth, and cell death signaling requires NgR1/p75NTR complex. p75NTR knockout in vivo, cerebellar neuron apoptosis assay, JNK pathway analysis, neurite outgrowth assay Cell death & disease Medium 31570696
2007 MUC1 is a counter-receptor for MAG (Siglec-4a) on pancreatic cancer cells; MAG binds pancreatic cells expressing MUC1 in a sialidase-sensitive manner, and MAG physically associates with MUC1. Increased expression of MUC1 or MAG enhances heterotypic adhesion between pancreatic cancer cells and Schwann cells, and specific inhibition of MAG or sialyl-T MUC1 partially blocks this adhesion. Heterotypic adhesion assay, Co-immunoprecipitation, sialidase sensitivity assay, antibody inhibition, overexpression experiments Cancer research Medium 17974963
2004 Progressive and selective loss of MAG protein from brain in mice lacking complex gangliosides (Galgt1-null) occurs with age (60% reduction at 6 months, 70% at 12 months) without reduction of MAG mRNA, indicating that complex gangliosides GD1a and GT1b are required for maintaining MAG protein stability—likely via enhanced stability when MAG on myelin binds its complementary ligands on the axon surface. Galgt1 gene knockout, Western blot, RT-PCR, age-course analysis Glycobiology Medium 15175257
1995 L-MAG is selectively removed from the periaxonal membrane of CNS myelinated fibers by receptor-mediated endocytosis in quaking mice; the cytoplasmic domain of L-MAG contains tyrosine internalization signals at Y35 and Y65, and increased endosomal accumulation of L-MAG is observed in quaking oligodendrocytes. S-MAG remains in periaxonal membranes. Immunoelectron microscopy, endosome labeling, sequence motif analysis of cytoplasmic domain, developmental time-course comparison The Journal of cell biology Medium 8557747
1997 Mice doubly deficient in MAG and N-CAM develop myelin degeneration approximately 4 weeks earlier than MAG-single-knockout mice, with increased degeneration profiles at 8 weeks; this genetic epistasis shows that N-CAM partially compensates for MAG in the maintenance (but not formation) of axon-myelin integrity in MAG-deficient mice. Double knockout mouse generation, electron microscopy, single fiber preparation, morphometric analysis Cell and tissue research Medium 9011400
2013 hnRNP A1 regulates alternative splicing of Mag exon 12 by interacting with an element overlapping the 5' splice site of exon 12; this element has reduced affinity for U1 snRNP, and an evolutionarily conserved RNA secondary structure modulates interactions with both hnRNP A1 and U1 snRNP, coordinately controlling the ratio of L-MAG to S-MAG isoforms. RNA reporter constructs, UV crosslinking/RNA binding assay, splice site mutagenesis, U1 snRNP interaction assay, secondary structure analysis RNA (New York, N.Y.) Medium 23704325
2006 S-MAG and L-MAG isoforms have distinct subcellular distributions in myelin: in peripheral nerves (where S-MAG is the sole isoform), S-MAG concentrates in periaxonal and abaxonal rings and disc-like structures spanning compact myelin perpendicular to the axon. L-MAG and S-MAG show differential developmental expression in CNS and PNS oligodendrocyte unit phenotypes. Transgenic mouse expressing GFP-tagged S-MAG, confocal microscopy, electron microscopy, immunolabeling Molecular and cellular neurosciences Medium 16442810
2017 GPR37 and MAG form a protein complex when co-expressed in cells; genetic deletion of Gpr37 (but not Gpr37L1) results in markedly decreased MAG protein expression in brain, and Gpr37-knockout mice show dramatically increased myelin loss in the cuprizone demyelination model without loss of oligodendrocyte precursors or mature oligodendrocytes. Co-immunoprecipitation, Western blot, Gpr37 knockout mouse, cuprizone demyelination model, proteomics Neuroscience Medium 28642167
2013 MAG membrane association is sulfatide-dependent; in mice lacking sulfatide (but retaining galactocerebroside), MAG shows increased susceptibility to detergent extraction from myelin membranes, while other myelin proteins (MOG, MBP, CNPase) are sulfatide-independent for their membrane association. In situ detergent extraction procedure on spinal cord sections, sulfatide-deficient mouse model, immunolabeling Neurochemical research Medium 24081651
2012 MAG plays an essential role in mediating axon-myelin attachment in CMT1A disease; ablating MAG in CMT1A mice (overexpressing human PMP22) results in separation of axons from their myelin sheath, demonstrating that increased MAG expression in CMT1A has a compensatory role in maintaining axonal integrity in the context of PMP22 overexpression. MAG knockout in CMT1A mouse model (PMP22 overexpressing), electron microscopy, immunohistochemistry, expression analysis Neurobiology of disease Medium 22940629
2016 Homozygous missense mutation p.Arg118His in MAG immunoglobulin domain 1 (a residue critical for sialic acid binding) causes a progressive neurological syndrome in humans with demyelinating leukodystrophy, establishing that the sialic acid-binding activity of MAG's Ig domain 1 is required for normal CNS function in vivo. Exome sequencing, clinical characterization, structural/functional annotation of MAG sialic acid binding site Annals of clinical and translational neurology Low 27606346
2022 Three-dimensional FIB-SEM reconstruction of Mag-null mouse CNS shows that MAG-deficient myelin exhibits pathological outfoldings extending up to 10 μm longitudinally along myelinated axons, with complex axonal pathology (including axonal sprouting) underneath outfoldings. Normal-appearing axon/myelin units in Mag-null mice display significantly increased axonal diameters, indicating that MAG is required for maintaining normal axonal diameter and shape. Focused ion beam-scanning electron microscopy (FIB-SEM), 3D reconstruction, morphometric analysis, Mag-null and Plp-null mouse comparison Glia Medium 36354016
1986 MAG is localized by immunoelectron microscopy to axon-Schwann cell apposition, Schmidt-Lanterman incisures, inner and outer mesaxons, and paranodal loops but not in compact myelin or at nodes of Ranvier; it appears after L1 expression ceases during myelination, establishing MAG's specific periaxonal localization distinct from compact myelin proteins like MBP. Pre- and post-embedding immunoelectron microscopy, developmental time-course The Journal of cell biology High 2430983

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature 664 12422217
1986 Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and MAG) and their shared carbohydrate epitope and myelin basic protein in developing sciatic nerve. The Journal of cell biology 445 2430983
2007 Myelin-associated glycoprotein (MAG): past, present and beyond. Journal of neurochemistry 248 17241126
2002 Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration. Proceedings of the National Academy of Sciences of the United States of America 217 12060784
1989 Immunohistological localization of the adhesion molecules L1, N-CAM, and MAG in the developing and adult optic nerve of mice. The Journal of comparative neurology 216 2474006
2010 MAG and OMgp synergize with Nogo-A to restrict axonal growth and neurological recovery after spinal cord trauma. The Journal of neuroscience : the official journal of the Society for Neuroscience 205 20484625
1988 Peripheral neuropathy and anti-MAG antibodies. Critical reviews in neurobiology 164 2458847
2005 MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. Neuron 145 15953414
1999 BIS-GMA--based resins in dentistry: are they safe? Journal of the American Dental Association (1939) 126 10036843
1988 Treatment of patients with neuropathy and anti-MAG IgM M-proteins. Annals of neurology 103 2458065
1991 Cytotoxicity of a BIS-GMA dental composite before and after leaching in organic solvents. Journal of biomedical materials research 102 1828807
2020 Targeting Endocannabinoid Signaling: FAAH and MAG Lipase Inhibitors. Annual review of pharmacology and toxicology 97 32867595
1996 Anti-MAG and anti-SGPG antibodies in neuropathy. Muscle & nerve 93 8618562
2007 MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion. Cancer research 92 17974963
1997 Soluble myelin-associated glycoprotein (MAG) found in vivo inhibits axonal regeneration. Molecular and cellular neurosciences 91 9361272
2015 MAG, myelin and overcoming growth inhibition in the CNS. Frontiers in molecular neuroscience 77 26441514
2003 Lipid rafts mediate the interaction between myelin-associated glycoprotein (MAG) on myelin and MAG-receptors on neurons. Molecular and cellular neurosciences 75 12691736
2018 Advances in the diagnosis, immunopathogenesis and therapies of IgM-anti-MAG antibody-mediated neuropathies. Therapeutic advances in neurological disorders 74 29403542
2016 Ketamine and MAG Lipase Inhibitor-Dependent Reversal of Evolving Depressive-Like Behavior During Forced Abstinence From Alcohol Drinking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 73 26751284
1997 Absence of the myelin-associated glycoprotein (MAG) and the neural cell adhesion molecule (N-CAM) interferes with the maintenance, but not with the formation of peripheral myelin. Cell and tissue research 67 9011400
1985 Generation and characterization of mouse monoclonal antibodies to the myelin-associated glycoprotein (MAG). Neurochemical research 67 2582290
2007 Exercise normalizes levels of MAG and Nogo-A growth inhibitors after brain trauma. The European journal of neuroscience 63 18093178
1983 Anti-MAG IgM antibodies in patients with neuropathy and IgM M proteins: detection by ELISA. Neurology 63 6191246
2000 Early onset of axonal degeneration in double (plp-/-mag-/-) and hypomyelinosis in triple (plp-/-mbp-/-mag-/-) mutant mice. The Journal of neuroscience : the official journal of the Society for Neuroscience 62 10884306
1991 Differential expression of MAG isoforms during development. Journal of neuroscience research 57 1716323
1998 MAG and MOG enhance neurite outgrowth of embryonic mouse spinal cord neurons. Neuroreport 55 9674579
1987 Neural protein 1B236/myelin-associated glycoprotein (MAG) defines a subgroup of the immunoglobulin superfamily. Immunological reviews 54 2450062
1999 Variability in the binding of anti-MAG and anti-SGPG antibodies to target antigens in demyelinating neuropathy and IgM paraproteinemia. Journal of neuroimmunology 53 10229128
1993 A common element involved in transcriptional regulation of two DNA alkylation repair genes (MAG and MGT1) of Saccharomyces cerevisiae. Molecular and cellular biology 53 8246943
1984 Neuropathy and anti-MAG antibodies without detectable serum M-protein. Neurology 53 6198602
2020 Reliable measurement of free Ca2+ concentrations in the ER lumen using Mag-Fluo-4. Cell calcium 52 32179239
2020 The Bruton tyrosine kinase inhibitor ibrutinib improves anti-MAG antibody polyneuropathy. Neurology(R) neuroimmunology & neuroinflammation 52 32284437
2012 LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin. Journal of cell science 50 23132925
2005 Expression of MBP, PLP, MAG, CNP, and GFAP in the Human Alcoholic Brain. Alcoholism, clinical and experimental research 50 16205370
2008 BDNF activates CaMKIV and PKA in parallel to block MAG-mediated inhibition of neurite outgrowth. Molecular and cellular neurosciences 49 18381242
2000 mag-1, a homolog of Drosophila mago nashi, regulates hermaphrodite germ-line sex determination in Caenorhabditis elegans. Developmental biology 47 10656761
2005 Shear stress alters the expression of myelin-associated glycoprotein (MAG) and myelin basic protein (MBP) in Schwann cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 46 16140204
2004 Myelin-associated glycoprotein (Siglec-4) expression is progressively and selectively decreased in the brains of mice lacking complex gangliosides. Glycobiology 46 15175257
1991 Induction of S.cerevisiae MAG 3-methyladenine DNA glycosylase transcript levels in response to DNA damage. Nucleic acids research 45 1754379
2002 Encephalitogenic and immunogenic potential of myelin-associated glycoprotein (MAG), oligodendrocyte-specific glycoprotein (OSP) and 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in ABH and SJL mice. Journal of neuroimmunology 43 11777540
1995 Purification and properties of the alkylation repair DNA glycosylase encoded the MAG gene from Saccharomyces cerevisiae. Biochemistry 42 7718559
2024 Mag-Net: Rapid enrichment of membrane-bound particles enables high coverage quantitative analysis of the plasma proteome. bioRxiv : the preprint server for biology 41 38617345
2004 Nogo-66 and myelin-associated glycoprotein (MAG) inhibit the adhesion and migration of Nogo-66 receptor expressing human glioma cells. Journal of neurochemistry 39 15312170
2001 [(99m)Tc]MAG(3)-mannosyl-dextran: a receptor-binding radiopharmaceutical for sentinel node detection. Nuclear medicine and biology 39 11516693
2010 Recent advances toward the inhibition of mAG and LAM synthesis in Mycobacterium tuberculosis. Medicinal research reviews 36 20099253
1998 Differential expression of the L- and S-isoforms of myelin associated glycoprotein (MAG) in oligodendrocyte unit phenotypes in the adult rat anterior medullary velum. Journal of neurocytology 33 10640185
2017 Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination. Neuroscience 32 28642167
2012 An essential role of MAG in mediating axon-myelin attachment in Charcot-Marie-Tooth 1A disease. Neurobiology of disease 32 22940629
2005 Identification of neuroprotective properties of anti-MAG antibody: a novel approach for the treatment of stroke? Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 32 15678116
1999 Encephalitogenic and neuritogenic T cell responses to the myelin-associated glycoprotein (MAG) in the Lewis rat. Journal of neuroimmunology 32 10229126
2006 Unraveling the differential expression of the two isoforms of myelin-associated glycoprotein in a mouse expressing GFP-tagged S-MAG specifically regulated and targeted into the different myelin compartments. Molecular and cellular neurosciences 31 16442810
1999 Myelin-associated glycoprotein, MAG, selectively binds several neuronal proteins. Journal of neuroscience research 31 10494110
1995 Endocytic depletion of L-MAG from CNS myelin in quaking mice. The Journal of cell biology 31 8557747
1982 Immunocytochemical study of myelin-associated glycoprotein (MAG) and basic protein (BP) in acute experimental allergic encephalomyelitis (EAE). Journal of neuroimmunology 31 6184382
2013 MAG-EPA resolves lung inflammation in an allergic model of asthma. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 30 23957343
2004 Evolution of sialic acid-binding proteins: molecular cloning and expression of fish siglec-4. Glycobiology 29 15229193
2007 Lack of adrenoleukodystrophy protein enhances oligodendrocyte disturbance and microglia activation in mice with combined Abcd1/Mag deficiency. Acta neuropathologica 28 17828604
2002 Multiple MAG peptides are recognized by circulating T and B lymphocytes in polyneuropathy and multiple sclerosis. European journal of neurology 28 11985632
1994 MAG, a novel plasma protein receptor from Streptococcus dysgalactiae. Gene 28 7515368
1989 Glomerular filtration and tubular secretion of MAG-3 in the rat kidney. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 27 2531220
2010 Myelin-associated glycoprotein (MAG) protects neurons from acute toxicity using a ganglioside-dependent mechanism. ACS chemical neuroscience 26 20436925
2002 Improving the labeling of S-acetyl NHS-MAG(3)-conjugated morpholino oligomers. Bioconjugate chemistry 26 12121147
1985 Anti-MAG antibody and antibody complexes: detection by radioimmunoassay. Neurology 26 2409476
2020 A Novel Siglec-4 Derived Spacer Improves the Functionality of CAR T Cells Against Membrane-Proximal Epitopes. Frontiers in immunology 25 32849600
2017 Overexpression of gma-miR1510a/b suppresses the expression of a NB-LRR domain gene and reduces resistance to Phytophthora sojae. Gene 25 28411083
2016 Selection and Identification of Chloramphenicol-Specific DNA Aptamers by Mag-SELEX. Applied biochemistry and biotechnology 25 27613616
2010 Monoacylglycerol (MAG)-oleic acid has stronger antioxidant, anti-atherosclerotic, and protein glycation inhibitory activities than MAG-palmitic acid. Journal of medicinal food 25 20136442
2017 Tissue-Specific Regulation of Gma-miR396 Family on Coordinating Development and Low Water Availability Responses. Frontiers in plant science 24 28694817
2013 Mycoplasma agalactiae MAG_5040 is a Mg2+-dependent, sugar-nonspecific SNase recognised by the host humoral response during natural infection. PloS one 23 23469065
2022 MetaLab-MAG: A Metaproteomic Data Analysis Platform for Genome-Level Characterization of Microbiomes from the Metagenome-Assembled Genomes Database. Journal of proteome research 22 36508259
2021 Soybean-derived gma-miR159a alleviates colon tumorigenesis by suppressing TCF7/MYC in mice. The Journal of nutritional biochemistry 22 33705946
2018 Effect of immobilization on the activity of catalase carried by poly(HEMA-GMA) cryogels. International journal of biological macromolecules 22 30452980
2001 Sensitisation to the lipid-binding apolipophorin allergen Der p 14 and the peptide Mag-1. International archives of allergy and immunology 21 11306926
1981 Immunocytochemical study of P0 glycoprotein, P1 and P2 basic proteins, and myelin-associated glycoprotein (MAG) in lesions of idiopathic polyneuritis. Neuropathology and applied neurobiology 21 6173794
2021 Facile multifunctional IOL surface modification via poly(PEGMA-co-GMA) grafting for posterior capsular opacification inhibition. RSC advances 20 35423496
2016 MAG-EPA reduces severity of DSS-induced colitis in rats. American journal of physiology. Gastrointestinal and liver physiology 20 27012773
2013 Expression pattern of Nogo-A, MAG, and NgR in regenerating urodele spinal cord. Developmental dynamics : an official publication of the American Association of Anatomists 20 23592243
2019 Development of Bis-GMA-free biopolymer to avoid estrogenicity. Dental materials : official publication of the Academy of Dental Materials 19 31791739
1985 Shared antigen between the myelin-associated glycoprotein (MAG) and a cell line from human T cell leukemia (HSB-2). Journal of neuroimmunology 19 2579092
1984 Myelin-associated glycoprotein (MAG) distribution in human central nervous tissue studied immunocytochemically with monoclonal antibody. Journal of neuroimmunology 19 6200494
2020 The effects of the dental methacrylates TEGDMA, Bis-GMA, and UDMA on neutrophils in vitro. Clinical and experimental dental research 18 32543782
2012 CRMP4 mediates MAG-induced inhibition of axonal outgrowth and protection against Vincristine-induced axonal degeneration. Neuroscience letters 18 22583768
1999 Interleukin-10 gene transfer activates interferon-gamma and the interferon-gamma-inducible genes Gbp-1/Mag-1 and Mig-1 in mammary tumors. International journal of cancer 18 9935167
1985 Immunocytochemical study of myelin-associated glycoprotein (MAG), basic protein (BP), and glial fibrillary acidic protein (GFAP) in chronic relapsing experimental allergic encephalomyelitis (EAE). Acta neuropathologica 18 2579517
2017 Ancestor of land plants acquired the DNA-3-methyladenine glycosylase (MAG) gene from bacteria through horizontal gene transfer. Scientific reports 17 28839126
2015 N-acetyl cysteine protects human oral keratinocytes from Bis-GMA-induced apoptosis and cell cycle arrest by inhibiting reactive oxygen species-mediated mitochondrial dysfunction and the PI3K/Akt pathway. Toxicology in vitro : an international journal published in association with BIBRA 17 26343756
2020 Selective inhibition of anti-MAG IgM autoantibody binding to myelin by an antigen-specific glycopolymer. Journal of neurochemistry 16 32270492
1998 MAG-deficient Schwann cells myelinate dorsal root ganglion neurons in culture. Glia 16 9482208
1998 Correlation between cytomegalovirus infection and IgM anti-MAG/SGPG antibody-associated neuropathy. Annals of neurology 16 9749612
1989 Myelin-associated glycoprotein (MAG) and rat brain-specific 1B236 protein: mapping of epitopes and demonstration of immunological identity. Journal of molecular neuroscience : MN 16 2484442
2022 Focused ion beam-scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag. Glia 15 36354016
2019 MAG induces apoptosis in cerebellar granule neurons through p75NTR demarcating granule layer/white matter boundary. Cell death & disease 15 31570696
2018 Anti-MAG neuropathy: Role of IgM antibodies, the paranodal junction and juxtaparanodal potassium channels. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 15 30144659
2016 Therapeutic options and management of polyneuropathy associated with anti-MAG antibodies. Expert review of neurotherapeutics 15 27267749
2014 MAG-EPA and 17,18-EpETE target cytoplasmic signalling pathways to reduce short-term airway hyperresponsiveness. Pflugers Archiv : European journal of physiology 15 25113382
2013 hnRNP A1 and secondary structure coordinate alternative splicing of Mag. RNA (New York, N.Y.) 15 23704325
2016 Neurologic syndrome associated with homozygous mutation at MAG sialic acid binding site. Annals of clinical and translational neurology 14 27606346
2013 Nfasc155H and MAG are specifically susceptible to detergent extraction in the absence of the myelin sphingolipid sulfatide. Neurochemical research 14 24081651
2010 B-cell-activating factor in rituximab-treated patients with anti-MAG polyneuropathy. Journal of neurology, neurosurgery, and psychiatry 14 21172861
1995 Streptococcal protein MAG--a protein with broad albumin binding specificity. Biochimica et biophysica acta 13 7766685

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