Affinage

ANAPC5

Anaphase-promoting complex subunit 5 · UniProt Q9UJX4

Length
755 aa
Mass
85.1 kDa
Annotated
2026-04-28
55 papers in source corpus 24 papers cited in narrative 23 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ANAPC5 (APC5) is a core scaffolding subunit of the anaphase-promoting complex/cyclosome (APC/C), the multi-subunit E3 ubiquitin ligase that drives cell cycle progression by targeting cyclins, securin, and other regulators for proteasomal degradation. Together with APC1 and APC4, APC5 forms the platform subcomplex that bridges the catalytic module (APC2/APC11) to the TPR lobe, and this platform undergoes co-activator-induced conformational changes required for substrate ubiquitination initiation (PMID:9469815, PMID:12956947, PMID:21307936, PMID:27601667). Beyond its structural role in the APC/C, APC5 directly engages substrates and signaling partners: it binds E2F1 to promote K11-linked ubiquitination and degradation (PMID:22580462), interacts with CBP/p300 to stimulate acetyltransferase activity and suppress E1A-mediated transformation (PMID:16319895), associates with IL-17 receptor subunits and A20 to negatively regulate IL-17 signaling (PMID:23922952), and mediates ubiquitination of GPAA1 and EGFR linking APC/C activity to GPI-anchored protein trafficking and macrophage polarization (PMID:41512182, PMID:40834712). During human cytomegalovirus infection, the viral protein pUL21a targets APC5 and APC4 for proteasome-dependent degradation, exploiting the co-dependent stability of platform subunits to dismantle the APC/C and override cell cycle control (PMID:22792066, PMID:25903336).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1998 High

    Identifying APC5 as a core APC/C subunit established that the complex contains previously uncharacterized components beyond the known CDC proteins, opening the question of what structural or catalytic role each subunit plays.

    Evidence Biochemical purification and cloning of human APC subunits from HeLa cells

    PMID:9469815

    Open questions at the time
    • No structural or catalytic function assigned to APC5 specifically
    • Stoichiometry within the complex unknown
  2. 2002 High

    Genetic studies in Drosophila and yeast revealed that APC5 is essential for APC/C-dependent degradation of cyclin B and for chromatin assembly, but not all APC/C substrates depend equally on APC5, raising the question of whether APC5 controls substrate selectivity.

    Evidence Drosophila ida mutant analysis with substrate-specific immunostaining; yeast rmc1/apc5 allele with in vitro chromatin assembly, genetic interactions, and cell cycle phenotyping

    PMID:11870214 PMID:12399376

    Open questions at the time
    • Mechanism by which APC5 contributes to substrate selectivity unclear
    • Whether chromatin assembly role is direct or indirect through substrate degradation
  3. 2003 High

    Biochemical reconstitution showed that APC5, APC1, and APC4 form a discrete platform subcomplex that supports multiubiquitin chain assembly but cannot bind co-activators or ubiquitinate substrates alone, defining a modular architecture for the APC/C.

    Evidence Biochemical fractionation of human APC subcomplexes, in vitro ubiquitination and CDH1 binding assays

    PMID:12609981 PMID:12956947

    Open questions at the time
    • No atomic-resolution structure of APC5 or the platform
    • How the platform communicates with the TPR lobe to enable co-activator binding
  4. 2004 Medium

    The discovery that APC5 binds poly(A)-binding protein and represses IRES-mediated translation revealed an unexpected non-canonical role for an APC/C subunit in translational regulation, though whether this occurs as part of the holo-complex or independently remained unresolved.

    Evidence Yeast three-hybrid screen, co-immunoprecipitation, IRES reporter assays, megakaryocytic differentiation experiments

    PMID:15082755

    Open questions at the time
    • Whether APC5 acts on translation as a free monomer or within the APC/C
    • Not independently replicated
    • Scope of mRNAs regulated unknown
  5. 2005 High

    Showing that APC5 (and APC7) directly bind and stimulate CBP/p300 acetyltransferase activity established a link between the APC/C and transcriptional co-activation, and explained how APC subunits suppress E1A-mediated transformation independently of ubiquitin ligase activity.

    Evidence Reciprocal co-IP, GST pulldown, acetyltransferase activity assays, reporter assays, siRNA knockdown, focus formation assay

    PMID:16319895

    Open questions at the time
    • Whether stimulation of CBP/p300 occurs in the context of intact APC/C or free APC5
    • Physiological transcriptional targets of the APC5–CBP/p300 axis unknown
  6. 2007 Medium

    Genetic studies of APC5 orthologs in C. elegans demonstrated that partial loss of APC5 function delays anaphase onset in a spindle assembly checkpoint-dependent manner, establishing APC5 as a rate-limiting component for mitotic timing and revealing mutual antagonism between the APC/C and the SAC.

    Evidence EMS mutagenesis, time-lapse imaging of C. elegans embryos, SAC component RNAi epistasis

    PMID:17237515 PMID:20944012 PMID:20944014

    Open questions at the time
    • Whether the SAC-dependent delay reflects direct APC5–SAC interaction or reduced APC/C catalytic capacity
    • Redundancy between APC5 paralogs complicates interpretation in non-mammalian systems
  7. 2010 High

    Discovery that HCMV infection induces proteasome-dependent degradation of APC5 and APC4 revealed that viruses exploit the co-dependent stability of platform subunits to dismantle the APC/C and reprogram the host cell cycle.

    Evidence Immunoblot of APC subunits during HCMV infection, proteasome inhibitor treatment, mutant virus analysis

    PMID:20686030 PMID:22792066

    Open questions at the time
    • Ubiquitin ligase responsible for APC5 degradation during infection not identified at this stage
  8. 2011 High

    Cryo-EM and crystallographic studies resolved the spatial organization of APC5 within the holo-APC/C, confirming its position in the platform and showing that its N-terminal α-helical domain makes stabilizing contacts with APC4, providing the first structural framework for understanding how the platform bridges catalytic and TPR modules.

    Evidence Cryo-EM at sub-nanometer resolution, X-ray crystallography of Apc5N and Apc4, fitting into 3.6-Å APC/C map

    PMID:21307936 PMID:26343760

    Open questions at the time
    • Full atomic model of APC5 C-terminus still lacking at the time
    • Conformational dynamics during catalytic cycle not resolved
  9. 2012 Medium

    Identification of APC5 as a direct binding partner of E2F1, required for APC/C(Cdh1)-mediated K11-linked ubiquitination and post-S-phase degradation of E2F1, connected the APC/C platform to cell cycle-dependent transcription factor turnover.

    Evidence Co-IP, GST pulldown, K11-specific ubiquitination assays, siRNA knockdown

    PMID:22580462

    Open questions at the time
    • Whether APC5 acts as a substrate receptor or facilitates co-activator-mediated recognition
    • Not independently replicated
  10. 2013 Medium

    APC5 was found to interact with IL-17 receptor subunits and A20, functioning as an inhibitory adaptor that restrains IL-17 signaling — the first evidence placing an APC/C subunit in cytokine receptor signaling.

    Evidence Yeast two-hybrid, co-IP, siRNA knockdown with IL-17-responsive reporter assays

    PMID:23922952

    Open questions at the time
    • Whether APC5 acts in this context as part of the holo-APC/C or independently
    • Mechanism of A20 recruitment through APC5 not detailed
    • Not independently replicated
  11. 2016 High

    Mutagenesis of APC1 within the platform showed that the platform subcomplex (including APC5) participates in a co-activator-induced allosteric transition required for UbcH10 engagement and substrate ubiquitination initiation, moving APC5 from a purely structural role to one involved in catalytic regulation.

    Evidence Crystal structure of Apc1N, cryo-EM of Apc1-WD40-deletion APC/C–Cdh1 complex, in vitro ubiquitination assays

    PMID:27601667

    Open questions at the time
    • Direct contribution of APC5 residues to the allosteric mechanism not dissected
    • Whether APC5 undergoes conformational changes during catalysis
  12. 2025 Medium

    Two recent studies extended APC5's substrate repertoire to GPAA1 and EGFR, linking APC/C-mediated ubiquitination to GPI-anchored protein surface expression, tumor immune evasion, and macrophage polarization — expanding the functional scope of APC5 beyond canonical cell cycle control.

    Evidence Co-IP and ubiquitination assays for GPAA1 and EGFR, preclinical tumor models, macrophage polarization assays with genetic rescue

    PMID:40834712 PMID:41512182

    Open questions at the time
    • Whether GPAA1 and EGFR are direct APC/C substrates recognized through canonical degron motifs
    • Each finding from a single lab and not yet independently replicated
    • Relative contribution of APC5 versus other APC/C subunits to these substrate interactions unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved whether APC5's non-canonical functions (CBP/p300 stimulation, PABP binding, IL-17 signaling) occur within the context of the intact APC/C holoenzyme or reflect moonlighting activities of free APC5, and the structural basis for APC5's direct engagement of specific substrates has not been determined.
  • No reconstitution separating holo-APC/C-dependent from APC5-autonomous activities
  • No structural model of APC5 bound to any non-canonical partner
  • Relative physiological importance of canonical versus non-canonical APC5 functions untested in genetic models

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 5 GO:0005198 structural molecule activity 4 GO:0098772 molecular function regulator activity 2 GO:0060090 molecular adaptor activity 1
Localization
GO:0005634 nucleus 3 GO:0005829 cytosol 2
Pathway
R-HSA-1640170 Cell Cycle 8 R-HSA-392499 Metabolism of proteins 4 R-HSA-1643685 Disease 2 R-HSA-168256 Immune System 2
Partners
ANAPC1ANAPC4ANAPC7CREBBPE2F1EP300PABPC1TNFAIP3
Complex memberships
APC/CAPC/C platform subcomplex (APC1/APC4/APC5)

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 ANAPC5 (APC5) was identified as one of four previously uncharacterized subunits of the anaphase-promoting complex (APC/C), an eight-subunit E3 ubiquitin ligase that targets cell cycle regulators for degradation; APC5 shares no similarity to proteins of known function but is a core structural component of the complex. Biochemical purification and cloning of human APC subunits Science High 9469815
2003 APC5, together with APC1 and APC4, forms a scaffold subcomplex that connects the catalytic module (APC2/APC11) with the TPR subunits; this subcomplex can assemble multiubiquitin chains but cannot bind the co-activator CDH1 or ubiquitinate substrates alone. Biochemical fractionation and reconstitution of human APC subcomplexes; in vitro ubiquitination assays; CDH1 binding assays Current Biology High 12956947
2011 Cryo-EM combined with mass spectrometry and crystallographic docking defined APC5 as a scaffolding subunit that, together with APC1 and APC4 (the platform subcomplex), coordinates juxtaposition of the catalytic module (APC2/APC11/APC10) and the TPR subcomplex (CDC16/CDC23/CDC27) within the APC/C. Electron microscopy, mass spectrometry, recombinant reconstitution of holo-APC/C, and docking of crystallographic coordinates Nature High 21307936
2015 Crystal structure of the N-terminal domain of human APC5 (Apc5N) was determined, revealing an α-helical fold; in the context of the APC/C cryo-EM map, Apc5N shows small conformational changes and regions of Apc4 disordered in crystal gain order through contacts with Apc5. X-ray crystallography of Apc5N and Apc4; fitting into 3.6-Å cryo-EM map of APC/C Journal of Molecular Biology High 26343760
2016 APC5 is part of the platform subcomplex (Apc1/Apc4/Apc5/Apc15); deletion of the Apc1 WD40 domain locks the APC/C into an inactive conformation, implicating the platform in the coactivator-induced allosteric transition that allows UbcH10 binding and substrate ubiquitination initiation. Crystal structure of Apc1N, cryo-EM of mutant APC/C-Cdh1 complex lacking Apc1(WD40), in vitro ubiquitination assays PNAS High 27601667
2005 APC5 and APC7 directly interact with the transcriptional co-activators CBP and p300 through evolutionarily conserved protein-protein interaction domains (shared with adenovirus E1A); this interaction stimulates CBP/p300 acetyltransferase activity and potentiates CBP/p300-dependent transcription. APC5 and APC7 suppress E1A-mediated transformation in a CBP/p300-dependent manner. Co-immunoprecipitation, GST pulldown, acetyltransferase activity assays, reporter gene assays, siRNA knockdown, focus formation assay Nature High 16319895
2004 APC5 (Apc5) binds poly(A) binding protein (PABP) and represses IRES-mediated translation of PDGF-2 mRNA; APC5 overexpression counteracts PABP-stimulated IRES activity, and APC5 is degraded upon megakaryocytic differentiation in correlation with IRES activation. Yeast three-hybrid screen, co-immunoprecipitation, sucrose gradient sedimentation with ribosomal fraction, IRES reporter assays, differentiation experiments Molecular and Cellular Biology Medium 15082755
2013 APC5 (AnapC5) interacts with both IL-17RA and IL-17RC receptor subunits and with the negative regulator A20 (TNFAIP3); siRNA silencing of AnapC5 enhanced IL-17-induced gene expression, identifying AnapC5 as an inhibitory adaptor in IL-17 signaling distinct from the Itch/TAXBP1 scaffold used in TNFα/IL-1 pathways. Yeast 2-hybrid screen, siRNA knockdown, co-immunoprecipitation, IL-17-responsive reporter gene assays PLoS One Medium 23922952
2012 APC5 binds E2F1 (identified by Co-IP in vivo and GST pulldown in vitro) and is essential for APC/C(Cdh1)-mediated K11-linked ubiquitination and proteasomal degradation of E2F1 after S phase. Co-immunoprecipitation, GST pulldown, ubiquitination assays with K11-specific ubiquitin, siRNA knockdown, proteasome inhibitor experiments Cell Cycle Medium 22580462
2010 During HCMV infection of quiescent cells, APC5 and APC4 are degraded in a proteasome-dependent manner, temporally associated with APC/C disassembly; immediate early viral gene expression is not sufficient, implicating early viral gene products in APC5 degradation. Immunoblot, proteasome inhibitor treatment, mutant virus infection (ΔUL97), mass spectrometry analysis of Cdh1 phosphorylation Journal of Virology Medium 20686030
2012 HCMV protein pUL21a binds the APC/C and is necessary and sufficient for proteasome-dependent degradation of APC5 and APC4 subunits, causing APC/C disruption; residues P109-R110 of pUL21a are critical for APC binding and regulation. Proteomics/MS, Co-IP, siRNA knockdown, point mutant virus construction, ubiquitin ligase activity assays PLoS Pathogens High 22792066
2015 A cellular mechanism exists whereby depletion of any one of APC1, APC4, APC5, or APC8 leads to co-dependent downmodulation of all three platform subunits (APC1, APC4, APC5); this inter-dependency was demonstrated in uninfected cells independent of viral infection. siRNA knockdown of individual APC subunits, immunoblot quantification of co-depletion Journal of Virology Medium 25903336
2002 In Drosophila, IDA (the APC5 ortholog) is required for APC/C function in imaginal disc cell proliferation; ida mutants show high mitotic index, aneuploid chromosomes, and failure to degrade cyclin B, but some APC/C substrates controlling sister-chromatid separation are still turned over, suggesting APC5 controls specific regulatory subfunctions of the APC/C. Genetic cloning and characterization, immunofluorescence cytology, cyclin B immunostaining in mutant brains Journal of Cell Science High 11870214
2003 In budding yeast, Mnd2 and Swm1 (novel APC subunits) interact directly with Apc5 (and Cdc23/Apc1) when coexpressed in vitro, placing Apc5 as a docking site for these peripheral APC subunits. Mass spectrometry of purified APC, in vitro transcription/translation co-immunoprecipitation, epitope-tagging co-purification Journal of Biological Chemistry Medium 12609981
2009 In fission yeast, transcription factor Atf1 physically binds the APC/C in vivo and addition of purified Atf1 to a cell-free system stimulates APC/C-dependent ubiquitylation of cyclin B and securin; Atf1 suppresses the mitotic arrest of the apc5-1 mutant in a bZIP-domain-independent manner. Genetic suppressor screen, co-immunoprecipitation, cell-free ubiquitination assay with purified Atf1 Journal of Biological Chemistry Medium 19584054
2002 In yeast, APC5 (RMC1) is required for in vitro chromatin assembly; the rmc1/apc5 allele genetically interacts with apc9Δ, apc10Δ, and cdc26Δ, and confers UV sensitivity, plasmid loss, and G2/M accumulation, establishing APC5 as required for APC-dependent chromatin assembly and genomic stability. In vitro chromatin assembly screen, genetic interaction analysis, cell cycle FACS, UV survival assays Genetics Medium 12399376
2013 In yeast, Apc5 (used as two-hybrid bait) interacts with the lifespan determinant Fob1; Fob1 is unstable in G1 and stabilized in apc5(CA) and rpn10 (proteasome) mutants, and a putative L-box destruction motif in Fob1 is required for its modifications, placing Fob1 as an APC/C substrate that influences rDNA stability and replicative lifespan. Yeast two-hybrid, protein stability assays (cycloheximide chase), mutant analysis (apc5CA, rpn10), lifespan assays, rDNA recombination assays Genetics Medium 24361936
2025 ANAPC5 mediates ubiquitination of GPAA1 (a catalytic subunit of GPI transamidase); radiation inhibits the APC/C complex, reducing ANAPC5-mediated ubiquitination of GPAA1, leading to GPAA1 accumulation, enhanced GPI anchoring of CD24, increased surface CD24 expression, and tumor immune evasion. Co-immunoprecipitation, ubiquitination assays, GPAA1 and CD24 expression analysis in irradiated cells, GPAA1/CD24 ablation in preclinical tumor models, flow cytometry Cancer Research Medium 41512182
2025 ANAPC5 overexpression inhibits M1 macrophage polarization and promotes M2 polarization in LPS-induced acute lung injury by inducing ubiquitination of EGFR, reducing EGFR activation and expression; EGFR knockdown reversed the inhibitory effects of ANAPC5 on inflammation, and EGFR suppressed CD24 expression downstream, placing ANAPC5 as a negative regulator of EGFR/CD24-axis-mediated macrophage polarization. ANAPC5 overexpression in vivo (ALI mouse model) and in vitro (macrophages), ubiquitination assays for EGFR, cytokine measurement, macrophage polarization markers, rescue experiments with EGFR Cellular Immunology Medium 40834712
2024 In mouse and human cell line models, co-depletion of ANAPC5 (APC5) exacerbates mitotic arrest induced by KIF18A depletion, while co-depletion of ANAPC7 partially rescues it, revealing that ANAPC5 and ANAPC7 have opposing effects on APC/C activity during mitosis and modulate sensitivity to KIF18A loss. siRNA co-depletion experiments in cell lines, time-lapse mitotic progression assays, mouse genetic screen for loci modifying KIF18A-dependent germ cell depletion Scientific Reports / bioRxiv Medium 39677807 40596695
2007 In C. elegans, a mutation in the APC5-like component SUCH-1/APC5 delays anaphase onset in germline and early embryonic cells and acts as a suppressor of mdf-1/MAD1 (spindle assembly checkpoint) lethality by delaying mitotic progression with concomitant IFY-1/securin accumulation. EMS mutagenesis screen, time-lapse imaging of embryonic cells, IFY-1 immunostaining, genetic suppression analysis Genetics Medium 17237515
2010 In C. elegans, the two APC5 paralogs SUCH-1 and GFI-3 are co-expressed in germline but have non-overlapping expression in other tissues; single depletion has no meiotic effect, but co-depletion causes meiotic arrest, demonstrating redundant APC5 function during meiotic divisions. RNAi co-depletion, meiotic phenotype scoring, expression pattern analysis Genetics Medium 20944012
2010 In C. elegans, a novel allele of SUCH-1/APC5 causes prolonged mitosis that is dependent on the spindle assembly checkpoint (SAC); inactivation of SAC components MDF-1/MAD1 or MDF-2/MAD2 rescues mitotic timing in APC/C-compromised embryos assembling monopolar spindles, indicating mutual antagonism between APC/C (via APC5) and the SAC. Genetic characterization of such-1(t1668) allele, SAC component RNAi, time-lapse imaging of mitotic duration Genetics Medium 20944014

Source papers

Stage 0 corpus · 55 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2011 Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 259 21714072
1998 Identification of a cullin homology region in a subunit of the anaphase-promoting complex. Science (New York, N.Y.) 211 9469815
2003 TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. Current biology : CB 172 12956947
2011 Structural basis for the subunit assembly of the anaphase-promoting complex. Nature 137 21307936
2009 FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides. Journal of proteome research 85 19344176
2005 The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression. Nature 84 16319895
2012 The yeast forkhead transcription factors fkh1 and fkh2 regulate lifespan and stress response together with the anaphase-promoting complex. PLoS genetics 59 22438832
2003 Mnd2 and Swm1 are core subunits of the Saccharomyces cerevisiae anaphase-promoting complex. The Journal of biological chemistry 51 12609981
2002 Phenotypic characterization of Drosophila ida mutants: defining the role of APC5 in cell cycle progression. Journal of cell science 40 11870214
2012 Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation. Cell cycle (Georgetown, Tex.) 35 22580462
2004 A functional analysis reveals dependence on the anaphase-promoting complex for prolonged life span in yeast. Genetics 34 15514051
2010 Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1. Journal of virology 32 20686030
2012 Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a. PLoS pathogens 28 22792066
2007 Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells. British journal of cancer 25 17895889
2009 The transcription factor Atf1 binds and activates the APC/C ubiquitin ligase in fission yeast. The Journal of biological chemistry 24 19584054
2007 Suppressors of spindle checkpoint defect (such) mutants identify new mdf-1/MAD1 interactors in Caenorhabditis elegans. Genetics 24 17237515
2002 The ubiquitin-dependent targeting pathway in Saccharomyces cerevisiae plays a critical role in multiple chromatin assembly regulatory steps. Genetics 24 12399376
2013 Validation of reference genes for the determination of platelet transcript level in healthy individuals and in patients with the history of myocardial infarction. International journal of molecular sciences 20 23389042
2021 System Biology-Guided Chemical Proteomics to Discover Protein Targets of Monoethylhexyl Phthalate in Regulating Cell Cycle. Environmental science & technology 19 33459556
2013 The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction. PloS one 19 23922952
2010 The Saccharomyces cerevisiae anaphase-promoting complex interacts with multiple histone-modifying enzymes to regulate cell cycle progression. Eukaryotic cell 19 20709786
2017 Co‑expression of Axin and APC gene fragments inhibits colorectal cancer cell growth via regulation of the Wnt signaling pathway. Molecular medicine reports 18 28731177
2011 Antagonistic Gcn5-Hda1 interactions revealed by mutations to the Anaphase Promoting Complex in yeast. Cell division 18 21651791
2016 WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity. Proceedings of the National Academy of Sciences of the United States of America 17 27601667
2015 Studies on the Contribution of Human Cytomegalovirus UL21a and UL97 to Viral Growth and Inactivation of the Anaphase-Promoting Complex/Cyclosome (APC/C) E3 Ubiquitin Ligase Reveal a Unique Cellular Mechanism for Downmodulation of the APC/C Subunits APC1, APC4, and APC5. Journal of virology 17 25903336
2013 The anaphase promoting complex regulates yeast lifespan and rDNA stability by targeting Fob1 for degradation. Genetics 16 24361936
2004 The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation. Molecular and cellular biology 16 15082755
2005 Contribution of CAF-I to anaphase-promoting-complex-mediated mitotic chromatin assembly in Saccharomyces cerevisiae. Eukaryotic cell 12 15821127
2015 Differential Expression of Cell Cycle Regulators During Hyperplastic and Hypertrophic Growth of Broiler Subcutaneous Adipose Tissue. Lipids 11 26017028
1998 New junction models for alternate-strand triple-helix formation. Chemistry & biology 11 9862797
2010 Mutual antagonism between the anaphase promoting complex and the spindle assembly checkpoint contributes to mitotic timing in Caenorhabditis elegans. Genetics 10 20944014
2017 A novel APC promoter 1B deletion shows a founder effect in Italian patients with classical familial adenomatous polyposis phenotype. Genes, chromosomes & cancer 9 28791770
2015 Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain. Journal of molecular biology 9 26343760
2010 Functional redundancy of paralogs of an anaphase promoting complex/cyclosome subunit in Caenorhabditis elegans meiosis. Genetics 8 20944012
2024 Unraveling the molecular pathogenesis of Type 2 Diabetes and its impact on female infertility: A bioinformatics and systems biology approach. Computers in biology and medicine 7 39116715
2020 The role of CAMKK2 polymorphisms in HIV-associated sensory neuropathy in South Africans. Journal of the neurological sciences 7 32585444
2019 Polymorphisms in CAMKK2 associate with susceptibility to sensory neuropathy in HIV patients treated without stavudine. Journal of neurovirology 7 31309408
2006 Cross-talk between APC/C and CBP/p300. Cancer biology & therapy 7 16861917
2021 Morpho-molecular and mating-type locus diversity of Ustilaginoidea virens: an incitant of false smut of rice from Southern parts of India. Journal of applied microbiology 5 33772985
2003 Methods designed for the identification and characterization of in vitro and in vivo chromatin assembly mutants in Saccharomyces cerevisiae. Biological procedures online 5 14615812
2001 Expression of anaphase-promoting complex 5 in balloon angioplasty-injured rat carotid arteries and mitogen-stimulated human vascular smooth muscle cells. Biochemical and biophysical research communications 4 11401522
2025 Utility of a Large Series of B-Cell Precursor Acute Lymphoblastic Leukemia Cell Lines as a Model System. Cancer medicine 3 40022573
2021 Using Budding Yeast to Identify Molecules That Block Cancer Cell 'Mitotic Slippage' Only in the Presence of Mitotic Poisons. International journal of molecular sciences 3 34360748
2025 Two cGMP-dependent protein kinases have opposing effects on molt-inhibiting hormone regulation of Y-organ ecdysteroidogenesis. The Journal of experimental biology 2 39850985
2025 Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches. Journal of applied genetics 1 40531429
2010 [Effect of recombinant pEGFP-N3-APC vectors carrying various APC functional domains on the expression of beta-catenin in HT-29 cells]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 1 20197613
2026 Radiation-Enhanced CD24 Membrane Trafficking via GPI Anchoring Mediates Antitumor Immune Evasion. Cancer research 0 41512182
2026 Single-Cell and Mendelian Randomization Analyses Identify Key Genes Common to COVID-19 and Multiple Sclerosis. Viral immunology 0 41841545
2026 Dracocephalum tanguticum Maxim Polysaccharide Ameliorate Autoimmune Hepatitis via Regulating TNF and IL-17 Signaling Pathways. Food science & nutrition 0 42016259
2025 Therapeutic targeting of alternative pathway and C5 but not C5a protects from disease development in a preclinical model of autoimmune blistering dermatosis. Frontiers in immunology 0 40370446
2025 Anapc5 and Anapc7 as genetic modifiers of KIF18A function in fertility and mitotic progression. Scientific reports 0 40596695
2025 ANAPC5 mitigates acute lung injury through regulating macrophage M1/M2 polarization via the EGFR/CD24 axis. Cellular immunology 0 40834712
2025 PTTG1 as a common promising target for PCOS, Ovarian Cancer, and Major Depressive Disorder patients. Computational biology and chemistry 0 40925190
2024 Anapc5 and Anapc7 as genetic modifiers of KIF18A function in fertility and mitotic progression. bioRxiv : the preprint server for biology 0 39677807
2018 [Identifying the Importance of MT-3 Expression for Neuroblastoma Cells]. Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti 0 29808689