Affinage

AKTIP

AKT-interacting protein · UniProt Q9H8T0

Length
292 aa
Mass
33.1 kDa
Annotated
2026-06-09
83 papers in source corpus 10 papers cited in narrative 10 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

AKTIP (also FTS/Ft1) is a UEV-domain adaptor protein that operates as a molecular linker across several cellular compartments, with its best-characterized role being the coupling of vesicular cargo to retrograde microtubule transport (PMID:18799622, PMID:34882091). In the cytoplasm it is a core, shared subunit of the FTS/Hook/FHIP (FHF) complex, associating with a conserved C-terminal motif of Hook proteins (Hook1/2/3) (PMID:18799622); distinct FHF assemblies link different cargos to dynein-dynactin, including FHIP1B-bound Rab5 early endosomes and FHIP2A-associated Rab1A ER-to-Golgi carriers (PMID:34882091), and the complex couples AP-4/ATG9A vesicles to dynein through Hook binding of the AP-4 μ4 subunit (PMID:32073997). At telomeres AKTIP binds the shelterin proteins TRF1 and TRF2 and, together with TRF1 and the replication factors PCNA and RPA70, facilitates telomeric DNA replication; its depletion produces telomere dysfunction foci and intra-S checkpoint arrest (PMID:26110528). At the nuclear lamina it interacts with A- and B-type lamins, and its rim localization is co-dependent on lamin expression and nuclear morphology, with loss producing senescence and progeroid features (PMID:27512140, PMID:36096808). During mitosis AKTIP is recruited to the midbody by MKLP1, where it acts as an ESCRT-I component that, with TSG101, drives CHMP4B recruitment and independently recruits IST1 to enable abscission (PMID:34449766). It also modulates AKT signaling, enhancing PDK1-AKT association and AKT phosphorylation after being phosphorylated by TLK1 (PMID:35366279), and its loss in ERα-positive breast cancer stabilizes ERα and engages JAK2-STAT3 survival signaling (PMID:36516775).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2008 High

    Established AKTIP/FTS as a stable subunit of a multiprotein complex, defining its first molecular framework: how it engages Hook proteins and functions in endosomal trafficking.

    Evidence Affinity purification-mass spectrometry, yeast two-hybrid, Co-IP, and EGF/endosome trafficking assays in mammalian cells

    PMID:18799622

    Open questions at the time
    • Did not resolve which motor or cargo-specific adaptor links FHF to transport
    • UEV domain catalytic/non-catalytic role unaddressed
  2. 2014 Medium

    Placed FTS within the cargo-transport hierarchy by showing it acts downstream of FhipA and is required for Hook-early endosome association and dynein-mediated motility.

    Evidence Genetic loss-of-function and live-cell imaging in the Aspergillus nidulans FtsA ortholog

    PMID:24870033

    Open questions at the time
    • Fungal model; mammalian assembly order not directly demonstrated here
    • Mechanism of FhipA stabilization by FtsA unknown
  3. 2015 High

    Revealed an unexpected nuclear function: AKTIP cooperates with shelterin to support telomere replication, distinct from its cytoplasmic trafficking role.

    Evidence Co-IP, in vitro binding, ChIP, RNAi, TIF assay and Ft1/TRF1 epistasis in MEFs

    PMID:26110528

    Open questions at the time
    • Whether AKTIP enzymatically modifies shelterin or replication factors is unresolved
    • How the same protein partitions between telomeres and cytoplasm unaddressed
  4. 2016 High

    Connected AKTIP to the nuclear lamina, showing lamin interaction governs its rim localization and that its loss recapitulates progeroid/senescence phenotypes.

    Evidence Reciprocal Co-IP, immunostaining, and senescence-marker readouts after knockdown

    PMID:27512140

    Open questions at the time
    • Direct vs indirect lamin binding not separated
    • Functional consequence of lamina localization for telomere or trafficking roles unclear
  5. 2020 High

    Extended FHF cargo repertoire to AP-4/ATG9A vesicles, demonstrating the complex couples autophagy-related cargo to retrograde dynein transport.

    Evidence AP-MS, in vitro μ4-Hook direct binding, siRNA, and AP-4/ATG9A localization imaging

    PMID:32073997

    Open questions at the time
    • FTS-specific contribution vs Hook contribution to AP-4 binding not isolated
    • Physiological autophagy consequence not quantified
  6. 2021 High

    Defined AKTIP as a midbody ESCRT-I factor, establishing a mitotic abscission role with a defined recruitment hierarchy (MKLP1-dependent, CEP55-independent).

    Evidence Co-IP, super-resolution imaging, combinatorial siRNA of AKTIP/TSG101/MKLP1/CEP55, and multinucleation assay

    PMID:34449766

    Open questions at the time
    • Whether AKTIP's UEV domain mediates ubiquitin-dependent ESCRT recruitment unknown
    • Relationship to canonical CEP55-driven abscission unresolved
  7. 2021 High

    Resolved how a single shared scaffold serves multiple cargos by showing distinct FHIP/Hook combinations target FTS-containing complexes to Rab5 endosomes vs Rab1A ER-to-Golgi carriers.

    Evidence Proteomic interactome, single-molecule dynein reconstitution, live imaging, and GTP-Rab5 binding assay

    PMID:34882091

    Open questions at the time
    • FTS's precise mechanical role in the reconstituted motor complex not dissected
    • How cargo specificity is regulated in cells unknown
  8. 2021 Medium

    Linked AKTIP to AKT signaling, showing TLK1-mediated phosphorylation positions it as a modulator of PDK1-AKT association and AKT activation.

    Evidence Substrate/interactome analysis, Co-IP, phospho-site mapping, knockdown, and TLK1 inhibitor treatment

    PMID:35366279

    Open questions at the time
    • Single lab; physiological context of AKT modulation not established
    • How phosphorylation at T22/S237 changes AKTIP activity is unclear
  9. 2022 Medium

    Tied AKTIP loss to endocrine therapy resistance, showing it stabilizes ERα via CAND1 and engages JAK2-STAT3 survival signaling in breast cancer.

    Evidence Loss-of-function in MCF7 and patient-derived organoids, ubiquitin-proteasome assays, and co-inhibition rescue

    PMID:36516775

    Open questions at the time
    • Mechanism linking AKTIP to CAND1 upregulation unknown
    • Single lab; not validated in vivo
  10. 2022 Medium

    Refined the determinants of AKTIP lamina localization, showing nuclear morphology itself, not just lamin mutation type, dictates its rim distribution.

    Evidence Super-resolution co-localization in progerin-expressing HeLa and tumor cell models

    PMID:36096808

    Open questions at the time
    • Causal direction between AKTIP mislocalization and nuclear dysmorphology not established
    • Functional output of mislocalization unmeasured

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unknown whether AKTIP's UEV domain has any ubiquitin-related activity that unifies its telomeric, ESCRT, lamina, and dynein-cargo roles, or whether these reflect independent scaffold functions.
  • No catalytic or ubiquitin-binding activity demonstrated for the UEV domain
  • No structural model integrating its multiple binding interfaces
  • Regulation partitioning AKTIP among compartments uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0008092 cytoskeletal protein binding 2
Localization
GO:0005634 nucleus 2 GO:0005635 nuclear envelope 2 GO:0005768 endosome 2 GO:0005829 cytosol 2 GO:0000228 nuclear chromosome 1 GO:0005815 microtubule organizing center 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 3 R-HSA-162582 Signal Transduction 1 R-HSA-1640170 Cell Cycle 1 R-HSA-69306 DNA Replication 1
Partners
HOOK3MKLP1PCNARPA70TRF1TRF2TSG101VPS28
Complex memberships
ESCRT-IFTS/Hook/FHIP (FHF) complexshelterin (interacting)

Evidence

Reading pass · 10 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2015 AKTIP/Ft1 is a shelterin-interacting factor required for telomere maintenance. AKTIP binds the shelterin components TRF1 and TRF2 both in vivo and in vitro, interacts with telomeric DNA (ChIP), and physically interacts with PCNA and RPA70. RNAi-mediated depletion of AKTIP causes telomere dysfunction foci (TIFs) and S-phase arrest due to intra-S checkpoint activation. In Ft1-depleted p53-/- MEFs, multiple telomeric signals (MTS) and sister telomere associations (STAs) increase, phenotypes that are epistatic with TRF1, suggesting AKTIP/Ft1 works in concert with TRF1 to facilitate telomeric DNA replication. Co-IP, in vitro binding assays, ChIP, RNAi knockdown, immunofluorescence (TIF assay), epistasis analysis (Ft1/TRF1 double mutant), cell cycle analysis PLoS genetics High 26110528
2016 AKTIP biochemically interacts with A- and B-type lamins and affects lamin A (but not lamin C or B) expression. In interphase cells, AKTIP localizes at the nuclear rim and in discrete nucleoplasmic regions co-localizing with lamin B1 and lamin A/C; proper AKTIP localization requires functional lamin A. In mitotic cells, AKTIP is enriched at spindle poles and the midbody of late telophase cells. AKTIP-depleted cells exhibit senescence-associated markers and recapitulate aspects of the progeroid phenotype. Co-immunoprecipitation, double immunostaining, fluorescence microscopy, Western blot (lamin expression), knockdown with phenotypic readout (senescence markers) Open biology High 27512140
2021 During mitosis, AKTIP is part of the ESCRT machinery at the midbody. AKTIP interacts with the ESCRT I subunit VPS28 and forms a circular supra-structure at the midbody proximal to TSG101 and VPS28. AKTIP recruitment to the midbody depends on MKLP1 and is independent of CEP55. AKTIP and TSG101 together are required for recruitment of the ESCRT III subunit CHMP4B; in parallel, AKTIP (alone) is required for recruitment of IST1. AKTIP depletion alone impairs IST1 recruitment and causes multinucleation. Co-immunoprecipitation, super-resolution/proximity imaging, siRNA knockdown of AKTIP/TSG101/MKLP1/CEP55, immunofluorescence of midbody markers (CHMP4B, CHMP2A, IST1), multinucleation assay PLoS genetics High 34449766
2022 AKTIP loss in ERα-positive breast cancer stabilizes ERα protein via upregulation of CAND1, which protects ERα from cullin 2-dependent proteasomal degradation. Additionally, AKTIP loss triggers JAK2-STAT3 activation as an alternative survival pathway. AKTIP-depleted MCF7 cells and ERα-positive patient-derived organoids show resistance to ERα antagonists that can be overcome by co-inhibition of JAK2/STAT3. AKTIP knockdown/loss-of-function, Western blot (ERα protein levels, pSTAT3, CAND1), ubiquitin-proteasome assays, ERα antagonist treatment, patient-derived organoids, co-inhibition rescue experiments Cell reports Medium 36516775
2021 AKTIP, identified as a substrate of TLK1B, enhances the association of AKT with PDK1 and its phosphorylation at T308 and S473. TLK1 phosphorylates AKTIP at T22 and S237. Inactivation of TLK1 reduces AKT phosphorylation, which is potentiated by AKTIP knockdown. Interactome/substrate analysis, co-immunoprecipitation, Western blot (pAKT T308/S473), AKTIP knockdown, TLK1 inhibitor (J54) treatment, phospho-site mapping Pathophysiology Medium 35366279
2022 AKTIP localization at the nuclear rim is co-dependent on lamin expression and nuclear morphology. In HeLa cells, AKTIP co-localizes with lamin A/C at the rim; this is reduced in MCF7 and A549 tumor cells. AKTIP mislocalizes in HGPS (progerin-expressing) cells with altered nuclear morphology but not in EDMD2 cells. Progerin-expressing HeLa cells confirm that morphological nuclear alteration is sufficient to mislocalize AKTIP independently of lamin mutation type alone. Super-resolution imaging, quantitative co-localization analysis, lamin expression quantification, nuclear morphology measurement, progerin-expressing HeLa cell model Journal of experimental & clinical cancer research Medium 36096808
2008 FTS (AKTIP) is a member of the FTS/Hook/FHIP (FHF) multiprotein complex. FTS associates with a conserved C-terminal motif in Hook proteins (Hook1, Hook2, Hook3) as shown by yeast two-hybrid and co-immunoprecipitation. The ~500-kDa FHF complex interacts with members of both class B and class C components of the HOPS complex. siRNA depletion of FTS affects EGF trafficking from early-to-late endosome/lysosomes and impairs HOPS-mediated clustering of LAMP1-positive compartments. Affinity purification-mass spectrometry, yeast two-hybrid, Co-IP, siRNA knockdown, EGF trafficking assay, endosome clustering assay Molecular biology of the cell High 18799622
2014 In Aspergillus nidulans, loss of FtsA (the A. nidulans FTS homologue) disrupts HookA-early endosome association and inhibits early endosome movement. FtsA-early endosome association requires both FhipA and HookA, placing FtsA downstream of FhipA in the FHF complex for dynein-mediated early endosome transport. In the absence of FtsA, FhipA protein level is significantly reduced. Genetic screen, live-cell imaging, immunofluorescence (early endosome markers), protein level analysis by Western blot, co-localization studies Molecular biology of the cell Medium 24870033
2021 Different FTS-Hook-FHIP complexes associate with distinct dynein cargos. The FTS/FHIP1B/Hook1/Hook3 complex colocalizes with Rab5-positive early endosomes via a direct interaction between FHIP1B and GTP-bound Rab5. The FTS/FHIP2A/Hook2 complex colocalizes with Rab1A-tagged ER-to-Golgi cargos and is involved in Rab1A tubule motility. FTS participates in all these complexes as a shared scaffold. Proteomic interactome analysis, live-cell imaging, biochemical co-IP, in vitro reconstitution (single-molecule dynein motility assay), GTP-Rab5 binding assay eLife High 34882091
2020 The FHF complex (FTS/Hook/FHIP) interacts with adaptor protein complex 4 (AP-4) via direct binding of the AP-4 μ4 subunit to coiled-coil domains in Hook1 and Hook2. Knockdown of FHF subunits (including FTS) causes dispersal of AP-4 and its cargo ATG9A from the perinuclear region, consistent with FHF coupling these vesicles to the microtubule retrograde motor dynein-dynactin. Affinity purification-mass spectrometry, Co-IP, in vitro direct binding assay (μ4 to Hook coiled-coil), siRNA knockdown, immunofluorescence (AP-4 and ATG9A localization) Molecular biology of the cell High 32073997

Source papers

Stage 0 corpus · 83 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1996 FtsZ ring formation in fts mutants. Journal of bacteriology 256 8682793
1980 Organization of genes in the ftsA-envA region of the Escherichia coli genetic map and identification of a new fts locus (ftsZ). Journal of bacteriology 156 6991482
2008 An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Molecular biology of the cell 95 18799622
2012 Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer. Investigational new drugs 82 22547163
1980 Characterization of facteur thymique sérique (FTS) in the thymus. I. Fixation of anti-FTS antibodies on thymic reticulo-epithelial cells. Clinical and experimental immunology 80 7011612
1989 New mutations fts-36, lts-33, and ftsW clustered in the mra region of the Escherichia coli chromosome induce thermosensitive cell growth and division. Journal of bacteriology 67 2676977
1980 Induction of differentiation in human marrow T cell precursors by the synthetic serum thymic factor, FTS. Clinical and experimental immunology 65 6969145
1983 Marked reduction of DNA antibody production and glomerulopathy in thymulin (FTS-Zn) or cyclosporin A treated (NZB X NZW) F1 mice. Clinical and experimental immunology 61 6360436
2007 Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice. Cancer chemotherapy and pharmacology 57 17909812
1982 Improvement of cellular immunity and IgA production in immunodeficient children after treatment with synthetic serum thymic factor (FTS). Lancet (London, England) 55 6124716
2019 Formation of perfluorocarboxylic acids from 6:2 fluorotelomer sulfonate (6:2 FTS) in landfill leachate: Role of microbial communities. Environmental pollution (Barking, Essex : 1987) 54 31896477
1980 Specific receptors for the serum thymic factor (FTS) in lymphoblastoid cultured cell lines. Proceedings of the National Academy of Sciences of the United States of America 54 6248873
1994 In vitro lymphocyte-differentiating effects of thymulin (Zn-FTS) on lymphocyte subpopulations of severely malnourished children. The American journal of clinical nutrition 53 8030607
2014 FHIP and FTS proteins are critical for dynein-mediated transport of early endosomes in Aspergillus. Molecular biology of the cell 48 24870033
1982 Monoclonal antibody against the serum thymic factor (FTS). Immunology letters 48 7037626
1999 The Ras antagonist, farnesylthiosalicylic acid (FTS), inhibits experimentally-induced liver cirrhosis in rats. Journal of hepatology 47 10604579
2001 Treatment of MRL/lpr mice, a genetic autoimmune model, with the Ras inhibitor, farnesylthiosalicylate (FTS). Clinical and experimental immunology 42 11737078
2012 FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice. Cell death & disease 40 22419113
1984 Production of anti-thymulin (FTS) monoclonal antibodies by immunization against human thymic epithelial cells. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 39 6200531
2015 AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance. PLoS genetics 38 26110528
2021 Cytoplasmic dynein-1 cargo diversity is mediated by the combinatorial assembly of FTS-Hook-FHIP complexes. eLife 37 34882091
1991 Localization of sex steroid receptor cells, with special reference to thymulin (FTS)-producing cells in female rat thymus. Thymus 36 1926294
2003 Ras antagonist farnesylthiosalicylic acid (FTS) reduces glomerular cellular proliferation and macrophage number in rat thy-1 nephritis. Journal of the American Society of Nephrology : JASN 34 12660318
1982 Location of FTS (facteur thymique sérique) in the thymus of normal and auto-immune mice. Thymus 31 6890728
2014 EGF-induced expression of Fused Toes Homolog (FTS) facilitates epithelial-mesenchymal transition and promotes cell migration in ME180 cervical cancer cells. Cancer letters 28 24971934
2020 The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A. Molecular biology of the cell 27 32073997
2016 The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence. Open biology 26 27512140
1992 Localised mutagenesis of the fts YEX operon: conditionally lethal missense substitutions in the FtsE cell division protein of Escherichia coli are similar to those found in the cystic fibrosis transmembrane conductance regulator protein (CFTR) of human patients. Molecular & general genetics : MGG 25 1379670
2021 Inhibition of ERAD synergizes with FTS to eradicate pancreatic cancer cells. BMC cancer 24 33676427
2018 Silencing of FTS increases radiosensitivity by blocking radiation-induced Notch1 activation and spheroid formation in cervical cancer cells. International journal of biological macromolecules 23 30244128
2014 Targeted delivery of curcumin to tumors via PEG-derivatized FTS-based micellar system. The AAPS journal 21 24706375
2013 Genetic variant of AKT1 and AKTIP associated with late-onset depression in a Brazilian population. International journal of geriatric psychiatry 20 24022875
2011 The Ras antagonist, farnesylthiosalicylic acid (FTS), decreases fibrosis and improves muscle strength in dy/dy mouse model of muscular dystrophy. PloS one 20 21445359
2014 Ligand screening using fluorescence thermal shift analysis (FTS). Methods in molecular biology (Clifton, N.J.) 18 24590724
1983 Radioimmunoassays for the thymic hormone serum thymic factor (FTS). Journal of immunological methods 18 6827101
2021 AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody. PLoS genetics 17 34449766
2014 FTS is responsible for radiation-induced nuclear phosphorylation of EGFR and repair of DNA damage in cervical cancer cells. Journal of cancer research and clinical oncology 17 25151576
2012 Ras inhibition by FTS attenuates brain tumor growth in mice by direct antitumor activity and enhanced reactivity of cytotoxic lymphocytes. Oncotarget 17 22323550
2011 FTS (fused toes homolog) a novel oncoprotein involved in uterine cervical carcinogenesis and a potential diagnostic marker for cervical cancer. Journal of cellular physiology 17 20945372
2009 The Ras inhibitor farnesylthiosalicyclic acid (FTS) prevents nodule formation and development of preneoplastic foci of altered hepatocytes in rats. European journal of cancer (Oxford, England : 1990) 16 19427195
1984 Allogeneic bone marrow transplantation in man: in vitro activity of FTS-Zn on T-cell markers and functions. British journal of haematology 15 6097296
1984 Localization of thymulin (FTS-Zn) in mouse thymus. Comparative data using monoclonal antibodies following different plastic embedding procedures. Biology of the cell 15 6241489
1982 In vitro induction of monoclonal antibody-defined T-cell markers in lymphocytes from immunodeficient children by synthetic serum thymic factor (FTS). Clinical and experimental immunology 15 7049454
2016 Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity. Jornal de pediatria 14 27342216
2005 Serum thymic factor, FTS, attenuates cisplatin nephrotoxicity by suppressing cisplatin-induced ERK activation. Biochemical pharmacology 14 16154539
1983 In vitro modulation of mouse natural killer (NK) cell activity by the serum thymic factor (FTS). Cellular immunology 14 6682352
2014 Chloroquine synergizes with FTS to enhance cell growth inhibition and cell death. Oncotarget 13 24368422
1988 Thymulin (Zn-FTS) activity in protein-energy malnutrition: new evidence for interaction between malnutrition and infection on thymic function. The American journal of clinical nutrition 13 3124594
1981 Prolongation of murine skin grafts by FTS and its synthetic analogues. Clinical and experimental immunology 13 7032771
1984 Thymulin (FTS-Zn) induced in vitro modulation of T cell subsets markers on lymphocytes from rheumatoid arthritis and systemic lupus erythematosus patients. International journal of immunopharmacology 11 6332789
2012 A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluoropyrimidines dosing. Oncotarget 10 22824673
1982 Generation of a monoclonal antibody against facteur thymique serique (FTS). Clinical and experimental immunology 10 7044627
2021 Interaction of TLK1 and AKTIP as a Potential Regulator of AKT Activation in Castration-Resistant Prostate Cancer Progression. Pathophysiology : the official journal of the International Society for Pathophysiology 9 35366279
2015 Enhancing FTS (Salirasib) efficiency via combinatorial treatment. Biology of the cell 9 25735913
2022 Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP. Journal of experimental & clinical cancer research : CR 8 36096808
2011 Phenotypic reversion of invasive neurofibromin-deficient schwannoma by FTS: Ras inhibition reduces BMP4/Erk/Smad signaling. Molecular cancer therapeutics 8 21632464
1983 Studies of the thymus in mice bearing the Lewis lung carcinoma. II. Modulation of thymic natural killer activity by thymulin (FTS-Zn) and the antimetastatic effect of zinc. Clinical immunology and immunopathology 8 6688208
2022 AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance. Cell reports 7 36516775
2021 Silencing of Fused Toes Homolog (FTS) Increases Radiosensitivity to Carbon-Ion Through Downregulation of Notch Signaling in Cervical Cancer Cells. Frontiers in oncology 7 34765546
1983 Interaction of thymopoietin peptides with the specific receptor of facteur thymique serique (FTS). Thymus 7 6304947
1981 Influence of serum thymic factor (FTS) on radiation-induced leukaemogenesis in thymectomized AKR mice. International journal of cancer 7 7198101
2023 Toxoplasma gondii HOOK-FTS-HIP Complex is Critical for Secretory Organelle Discharge during Motility, Invasion, and Egress. mBio 6 37093045
2007 In vivo treatment with a nonapeptide thymic hormone, facteur thymique serique (FTS), ameliorates chronic colitis induced by dextran sulphate sodium in mice. International immunopharmacology 6 17499195
2023 MiRNA-106a-5p Promotes Laryngeal Carcinoma Proliferation and Migration Through PI3K/AKT/m-TOR Pathway by AKTIP. Iranian journal of biotechnology 5 36811106
2023 Exploring the utility of FTS as a bonafide binding partner for EGFR: A potential drug target for cervical cancer. Computers in biology and medicine 5 37976824
2014 Novel FTS-diamine/cinnamic acid hybrids inhibit tumor cell proliferation and migration and promote apoptosis via blocking Ras-related signaling in vitro. Cancer chemotherapy and pharmacology 5 25542266
1980 Nonspecific stimulation of antibacterial resistance by a synthetic thymic factor (FTS) in mice. Microbiology and immunology 5 7012549
2015 Cooperation of both, the FKBP_N-like and the DSBA-like, domains is necessary for the correct function of FTS_1067 protein involved in Francisella tularensis virulence and pathogenesis. Pathogens and disease 4 25896829
2011 Phosphorylation of threonine 190 is essential for nuclear localization and endocytosis of the FTS (Fused Toes Homolog) protein. International journal of biological macromolecules 4 21777610
2008 Remarkably high prevalence of fts I gene mutations in Haemophilus influenzae isolates from upper respiratory tract infections in children of the Sapporo district, Japan. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 4 18574659
2005 Protective effect of serum thymic factor, FTS, on cephaloridine-induced nephrotoxicity in rats. Biological & pharmaceutical bulletin 4 16272694
1990 Purification of thymocyte growth peptide (TGP) from sheep thymus. Relationship to FTS/thymulin. Bioscience reports 4 2249004
1984 The activity of synthetic analogs of serum thymic factor (FTS) to convert mouse pre-T cells into Thy-1 positive cells. International journal of immunopharmacology 4 6145673
1983 The stimulatory effect of serum thymic factor (FTS) on spontaneous DNA synthesis of mouse thymocytes. Cell and tissue kinetics 4 6188531
2017 Continuous treatment with FTS confers resistance to apoptosis and affects autophagy. PloS one 3 28151959
1983 Relationship between a spleen-derived immunosuppressive peptide 'SDIP' and the 'Facteur thymique sérique' (FTS): biochemical and biological comparison of the two factors. Immunology 3 6682089
1982 Activation of polyclonal antibody responses by a synthetic serum thymic factor (FTS) in CBA/N mice. Immunology 3 7037618
2016 Identification of two substrates of FTS_1067 protein - An essential virulence factor of Francisella tularensis. Acta microbiologica et immunologica Hungarica 2 27842441
1988 The distribution and structure of FTS immunoreactive cells in the thymus of the mouse. Archives of histology and cytology 2 3066304
2016 Should cell-free fetal DNA be included in first trimester screening (FTS) for common trisomy? A possible scenario on 6697 women screened over 10 years. Journal of evaluation in clinical practice 1 27345561
1995 Fts insertional mutant of Salmonella typhimurium. FEMS microbiology letters 1 7590167
2026 Comparative reproductive toxicity of 6:2 FTS and PFOS in female zebrafish (Danio rerio): From histopathology to molecular response. Ecotoxicology and environmental safety 0 42248039
2025 Identification of AKTIP as a biomarker for fibrolamellar carcinoma using WGCNA and machine learning. 3 Biotech 0 40417661

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