Affinage

ZNF281

Zinc finger protein 281 · UniProt Q9Y2X9

Length
895 aa
Mass
96.9 kDa
Annotated
2026-06-11
39 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/7 claims corpus-supported (86%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ZNF281 is a Krüppel-type zinc-finger transcription factor that binds GC-rich promoter elements to govern epithelial-mesenchymal transition (EMT), stemness, DNA repair, and metabolic gene programs (PMID:24185900, PMID:26300006). In the EMT axis it sits within a coherent feed-forward loop: it is induced by SNAIL and repressed by miR-34, then directly transactivates SNAIL (and ZEB1) to drive migration, invasion, stemness markers, and metastasis, with knockdown enforcing mesenchymal-to-epithelial reversion (PMID:24185900, PMID:32512343). It promotes Wnt/β-catenin signaling both by binding the β-CATENIN promoter and by binding β-catenin protein to reduce its polyubiquitination (PMID:28523575, PMID:22963690). ZNF281 acts as a positive regulator of DNA double-strand break repair, directly activating XRCC2 and XRCC4 transcription and being recruited to break sites within seconds in a DNA-binding-domain- and PARP-dependent manner, where it binds XRCC4 through its zinc fingers to facilitate non-homologous end joining (PMID:26300006, PMID:31570788). As a transcriptional repressor it recruits the NuRD complex (HDAC1, MTA1) to silence the tumor suppressor ANXA10, and it suppresses mitochondrial biogenesis by repressing TFAM, NRF1, and PGC-1α while physically interacting with NRF1 and PGC-1α (PMID:37880213, PMID:37041757). Its activity is constrained post-translationally: GSK-3β phosphorylates ZNF281 at S638 to trigger β-TrCP2-mediated ubiquitination and degradation (a loop reinforced by ZNF281 repression of β-TrCP2), and SUFU sequesters ZNF281 in the cytoplasm by masking its nuclear localization signal (PMID:29179460, PMID:36220888). Beyond cancer, ZNF281 partners with GATA1 to control erythroid maturation (PMID:31455666), and drives pathological tissue responses including hepatocyte senescence, NASH-associated necroptosis, and integrated-stress-response-driven cardiomyocyte toxicity (PMID:36514923, PMID:39724734, PMID:41984928).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2012 Medium

    Established a direct transcriptional link between ZNF281 and Wnt signaling and a role in stem cell fate, addressing how ZNF281 influences progenitor proliferation versus differentiation.

    Evidence ChIP at the β-CATENIN promoter plus gain/loss-of-function and in vivo scaffold implantation in human multipotent stem cells

    PMID:22963690

    Open questions at the time
    • Whether ZNF281 activates or represses β-CATENIN under different contexts not resolved
    • Single lab; co-regulators at the promoter unknown
  2. 2013 High

    Defined ZNF281 as a core node of an EMT feed-forward loop, answering how it is wired into the SNAIL/miR-34 circuit and whether it drives metastasis.

    Evidence ChIP, luciferase reporters, miR-34 target validation, ectopic/knockdown studies and xenograft metastasis in colorectal cancer cells

    PMID:24185900

    Open questions at the time
    • Direct co-repressor/co-activator partners at the SNAIL promoter not defined
    • Did not address post-translational control of ZNF281
  3. 2014 Medium

    Placed ZNF281 within the pluripotency network by identifying its physical association with core stemness factors.

    Evidence Co-immunoprecipitation reported via review citing original interaction data

    PMID:24838609

    Open questions at the time
    • No full experimental detail in the cited abstract
    • Functional consequence of each interaction not delineated
  4. 2015 High

    Revealed an unexpected role in DNA repair by showing ZNF281 directly transactivates HR and NHEJ effector genes, distinguishing its activity from c-MYC at the same promoters.

    Evidence ChIP, luciferase reporters, comet assay and siRNA knockdown after etoposide

    PMID:26300006

    Open questions at the time
    • Did not establish whether ZNF281 acts at break sites directly
    • Mechanism distinguishing ZNF281 from c-MYC at shared promoters not explained
  5. 2017 Medium

    Clarified how ZNF281 promotes Wnt signaling at the protein level and how it is degraded, defining both an activating interaction with β-catenin and a GSK-3β/β-TrCP2 turnover loop.

    Evidence Co-IP, Topflash reporters, S638A mutagenesis and ubiquitination assays in pancreatic and colorectal cancer cells

    PMID:28523575 PMID:29179460

    Open questions at the time
    • Single Co-IP for β-catenin without reciprocal structural validation
    • Whether GSK-3β-driven degradation operates across all ZNF281 functions not tested
  6. 2019 High

    Demonstrated that ZNF281 is a bona fide DNA-damage response factor recruited to break sites and physically delivering XRCC4 to support NHEJ.

    Evidence Live-cell imaging of recruitment kinetics, PARP inhibition, ZNF281-XRCC4 Co-IP, domain mutagenesis and NHEJ reporter assays

    PMID:31570788

    Open questions at the time
    • Signal triggering second-scale recruitment beyond partial PARP dependence not fully defined
    • Structural basis of the zinc-finger/XRCC4 interaction unknown
  7. 2019 High

    Established a tissue-specific developmental role by showing ZNF281 partners with GATA1 and Zfp148 to control erythroid maturation.

    Evidence Co-IP, ChIP-seq co-occupancy and double-knockout genetic epistasis in mice

    PMID:31112017 PMID:31455666 PMID:31782884

    Open questions at the time
    • Whether ZNF281 activates or represses erythroid targets directly not fully parsed
    • Redundancy mechanism with Zfp148 at the molecular level unresolved
  8. 2020 Medium

    Extended the EMT circuitry into breast cancer by adding ZEB1 transactivation and a miR-543 feedback loop downstream of TGF-β.

    Evidence ChIP, luciferase reporters, miR-543 target validation and in vitro/in vivo metastasis assays

    PMID:32512343

    Open questions at the time
    • Direct versus indirect contribution of each loop arm to metastasis not separated
    • Single lab
  9. 2022 Medium

    Identified two distinct control mechanisms — repressive metabolic gene targeting and cytoplasmic sequestration by SUFU — expanding how ZNF281 output is set.

    Evidence ChIP at the HK2 promoter with AAV-shRNA rescue; Co-IP, subcellular fractionation and ChIP inhibition for SUFU; RNA-seq and DSS colitis model for fibroblast activation

    PMID:36142169 PMID:36220888 PMID:36514923

    Open questions at the time
    • Whether SUFU regulation is constitutive or signal-dependent unknown
    • Direct fibroblast target genes not individually validated
  10. 2023 High

    Defined the repressive machinery ZNF281 uses, showing recruitment of the NuRD complex to silence ANXA10 and direct repression of mitochondrial biogenesis regulators.

    Evidence ChIP, Co-IP of ZNF281 with NuRD components and with NRF1/PGC-1α, RNA-seq, functional rescue (TFAM knockdown) and in vivo metastasis models

    PMID:37041757 PMID:37880213

    Open questions at the time
    • Determinants selecting activating versus NuRD-repressive mode at a given promoter unknown
    • Stoichiometry of ZNF281 within NuRD not defined
  11. 2024 High

    Connected ZNF281 to pathological cell death and stress, implicating it in NASH necroptosis, cardiotoxicity via the integrated stress response, and ROS-sensing senescence control.

    Evidence Hepatocyte- and cardiomyocyte-specific KO/OE mice, RIPK1/RIPK3/MLKL Western blot, anthracycline and NASH models, small-molecule inhibitors, single-cell transcriptomics and MSC senescence assays

    PMID:39254179 PMID:39724734 PMID:41984928

    Open questions at the time
    • Direct transcriptional targets driving necroptosis and cardiotoxicity not fully mapped
    • FOXO3/ROS loop in corneal cells rests on limited functional validation
  12. 2026 Medium

    Established a developmental neural patterning role for the ortholog by linking ZNF281 to BMP/Smad signaling modulation.

    Evidence Xenopus overexpression and morpholino knockdown with pSmad1/5/8 Western blot and neural/epidermal marker analysis

    PMID:41536077

    Open questions at the time
    • Whether ZNF281 acts directly on BMP pathway genes or indirectly not resolved
    • Mammalian relevance of the neural role untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How ZNF281 switches between transcriptional activation and NuRD-mediated repression at different promoters, and what upstream signals determine its context-specific output, remains unresolved.
  • No structural model of DNA or partner binding
  • Promoter-context determinants of activation versus repression unknown
  • Integration of phosphorylation, SUFU sequestration, and translational control into a unified regulatory logic not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003677 DNA binding 4 GO:0140110 transcription regulator activity 4
Localization
GO:0000228 nuclear chromosome 1 GO:0005634 nucleus 1 GO:0005829 cytosol 1
Pathway
R-HSA-74160 Gene expression (Transcription) 3 R-HSA-1266738 Developmental Biology 2 R-HSA-162582 Signal Transduction 2 R-HSA-73894 DNA Repair 2
Partners
BTRCCTNNB1GATA1NANOGNRF1PPARGC1ASUFUXRCC4
Complex memberships
NuRD complex

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 ZNF281 is directly transcriptionally induced by SNAIL (EMT transcription factor) and directly repressed by miR-34a/b/c, forming a coherent feed-forward loop. ZNF281 in turn directly activates SNAIL transcription, and ectopic ZNF281 induces EMT, increases migration/invasion, β-catenin activity, stemness markers LGR5/CD133, and sphere formation. Knockdown causes MET and inhibits lung metastases in mice. c-MYC induces ZNF281 protein in a SNAIL-dependent manner, and ZNF281 inactivation prevented EMT induced by c-MYC or SNAIL. ChIP, luciferase reporter assays, miR-34a target validation, siRNA knockdown, ectopic expression in CRC cells, xenograft metastasis model The EMBO journal High 24185900
2014 ZNF281 physically interacts with the pluripotency transcription factors NANOG, OCT4, SOX2, and c-MYC, implicating it in regulation of stemness and pluripotency networks. Co-immunoprecipitation (reported in review citing original interaction data) Journal of molecular medicine (Berlin, Germany) Medium 24838609
2015 ZNF281 transcriptionally activates XRCC2 (homologous recombination) and XRCC4 (NHEJ) through direct DNA-binding at their promoters. Cells silenced for ZNF281 show delayed DNA repair after etoposide treatment. c-MYC also binds the same promoters but cannot activate transcription or modify ZNF281 activity. Chromatin immunoprecipitation (ChIP), luciferase reporter assays, comet assay, siRNA knockdown Oncogene High 26300006
2017 ZNF281 promotes pancreatic cancer cell proliferation and invasion by directly binding β-catenin and decreasing its polyubiquitination, thereby activating Wnt/β-catenin signaling and downstream gene expression. Co-immunoprecipitation, Topflash luciferase assay, ectopic expression and knockdown, Western blot Digestive diseases and sciences Medium 28523575
2017 GSK-3β (not GSK-3α) phosphorylates ZNF281 at a consensus TSGEHS motif (S638), promoting interaction of ZNF281 with β-TrCP2 (not β-TrCP1), leading to ZNF281 ubiquitination and proteasomal degradation. A ZNF281-S638A mutant is resistant to this degradation. ZNF281 also transcriptionally represses β-TrCP2, forming a negative feedback loop. Mutational analysis (S638A), co-immunoprecipitation, ubiquitination assay, Western blot, CRC cell lines Oncotarget Medium 29179460
2019 ZNF281 is rapidly recruited to DNA double-strand break sites (within seconds of damage) via a mechanism dependent on its DNA-binding domain and, at least in part, PARP activity. ZNF281 physically binds XRCC4 through its zinc-finger domain and facilitates XRCC4 recruitment to damage sites. Depletion of ZNF281 impairs NHEJ efficiency and decreases cell viability after DNA damage. Live-cell imaging of recruitment kinetics, PARP inhibitor treatment, Co-immunoprecipitation (ZNF281-XRCC4), siRNA depletion with NHEJ reporter assay Oncogene High 31570788
2019 ZNF281 (Zfp281) physically associates with the master erythroid transcription factor GATA1, co-occupies many chromatin sites with GATA1 and Zfp148, and regulates a common set of erythroid differentiation genes. Combined deficiency of Zfp148 and Zfp281 causes a marked erythroid maturation block, demonstrating functional redundancy. Co-immunoprecipitation (Zfp281-GATA1), ChIP-seq, conditional knockout mice, genetic epistasis (double knockout) Blood advances High 31455666
2019 ZNF281 knockdown in CRC cells suppresses cell proliferation, migration, and invasion by inhibiting the Wnt/β-catenin pathway. siRNA knockdown, Transwell assay, wound healing assay, Western blot Cellular physiology and biochemistry Low 31112017
2019 ZNF281/Zfp281 is down-regulated during epithelial, muscle, and granulocytic differentiation. ZNF281 inhibits muscle differentiation promoted by miR-1, and is a direct post-transcriptional target of miR-1 acting through the ZNF281 3'UTR. 3'UTR luciferase reporter assays for miR binding sites, differentiation assays, expression analysis in rhabdomyosarcoma/leiomyosarcoma Molecular oncology Medium 31782884
2020 ZNF281 transactivates the EMT-related transcription factors ZEB1 and Snail. Both ZEB1 and Snail can transcriptionally suppress miR-543 expression, while miR-543 directly targets ZNF281, establishing a ZNF281-miR-543 feedback loop that regulates TGF-β-induced breast cancer metastasis. Luciferase reporter assay, ChIP, miR-543 target validation, in vitro and in vivo metastasis assays Molecular therapy. Nucleic acids Medium 32512343
2012 ZNF281 binds the promoter region of β-CATENIN and transcriptionally regulates its expression. ZNF281 knockdown in human multipotent stem cells (hMSCs) leads to spontaneous osteochondrogenic differentiation in vivo and in vitro, while overexpression accelerates proliferation. β-CATENIN expression correlates with ZNF281 expression. ChIP assay, siRNA knockdown, overexpression, in vivo subcutaneous implantation with β-TCP scaffold Cell transplantation Medium 22963690
2022 ZNF281 directly binds the 5'-GGCGGCGGGCGG-3' motif in the HK2 promoter and transcriptionally represses HK2 expression, thereby suppressing HK2-PINK1/Parkin signaling-mediated mitophagy and driving hepatocyte senescence in alcoholic liver disease. Knockdown of ZNF281 (including by AAV-shRNA in vivo) rescues mitophagy and reduces senescence. ChIP assay, promoter binding motif identification, siRNA knockdown, AAV-shRNA in vivo knockdown, mitophagy/senescence assays Cell proliferation Medium 36514923
2022 SUFU binds ZNF281 and masks its nuclear localization signal (NLS), causing cytoplasmic retention of ZNF281, thereby suppressing ZNF281-induced tumor cell migration and DNA damage repair. SUFU also hampers interactions between ZNF281 and promoters of target genes. This defines a Hedgehog-independent anti-tumor role for SUFU. Co-immunoprecipitation, subcellular fractionation/localization assays, in vivo tumor cell migration model, ChIP (promoter binding inhibition) Cell death and differentiation Medium 36220888
2022 ZNF281 is required for colon fibroblast activation and myofibroblast differentiation in response to TGFβ1. ZNF281 knockdown in fibroblasts reduces expression of genes involved in extracellular matrix composition, remodeling, and cell contraction, as identified by RNA-sequencing. siRNA knockdown, RNA-sequencing, TGFβ1 stimulation assay, DSS colitis mouse model International journal of molecular sciences Medium 36142169
2023 ZNF281 suppresses transcription of TFAM, NRF1, and PGC-1α (mitochondrial biogenesis regulators), and physically interacts with NRF1 and PGC-1α. ZNF281 is recruited to the promoter regions of TFAM, TFB1M, and TFB2M to repress their expression. Knockdown of ZNF281 increases mitochondrial content, OCR, and TCA cycle intermediates, and knockdown of TFAM reverses these effects. This suppression of mitochondrial biogenesis facilitates HCC invasion and metastasis. Co-immunoprecipitation (ZNF281-NRF1, ZNF281-PGC-1α), ChIP, siRNA knockdown, OCR measurement, RNA-seq, xenograft metastasis model Cell death discovery High 37880213
2023 ZNF281 interacts with the ANXA10 promoter at ZNF281 recognition sites and recruits components of the NuRD complex (including HDAC1 and MTA1) to transcriptionally repress tumor suppressor ANXA10. Knockdown of HDAC1 or MTA1 releases ANXA10 from repression and reverses EMT, invasion, and metastasis driven by ZNF281. ChIP, Co-immunoprecipitation (ZNF281-NuRD components), RNA-seq (target identification), siRNA knockdown of HDAC1/MTA1, in vivo pulmonary metastasis model Journal of hepatocellular carcinoma High 37041757
2024 ZNF281 upregulates the RIPK1/RIPK3/MLKL necroptosis signaling axis in hepatocytes under free fatty acid stress, promoting lipid accumulation and inflammatory cell death in NASH. Hepatocyte-specific Zfp281 knockout prevents NASH diet-induced liver injury, steatosis, inflammation, and fibrosis. Pterostilbene was identified as a ZNF281 inhibitor that recapitulates these protective effects. Hepatocyte-specific conditional knockout mice (AAV-shRNA), Western blot for RIPK1/RIPK3/MLKL, in vivo NASH diet model, pharmacological inhibition with pterostilbene International immunopharmacology Medium 39724734
2024 ZNF281 forms a positive feedback loop with FOXO3 to sense elevated ROS levels, potentially regulating mitochondrial respiratory chain components and superoxide dismutase (SOD) expression in corneal cells during aging. Overexpression of ZNF281 in MSCs prevented cellular senescence. Single-cell transcriptomics (comparative nonhuman primate), ZNF281 overexpression in MSCs, ROS/senescence assays Aging cell Low 39254179
2026 Anticancer agents (intercalating/alkylating agents, tyrosine kinase inhibitors, receptor inhibitors) converge to increase selective translational upregulation of ZNF281 in cardiomyocytes as part of the integrated stress response. Cardiomyocyte-specific ZNF281-deficient mice are resistant to anthracycline-induced cardiotoxicity, while cardiomyocyte-specific ZNF281-overexpressing mice develop cardiotoxicity features. A small-molecule inhibitor ZIM prevented anthracycline-induced cardiotoxicity and enhanced anti-tumor effects. Cardiomyocyte-specific conditional knockout and overexpression mice, anthracycline cardiotoxicity model, small-molecule inhibitor (ZIM), translational analysis, human myocardial tissue validation Science translational medicine High 41984928
2026 Znf281 (Xenopus ortholog) overexpression reduces levels of phosphorylated Smad1/5/8 (downstream effectors of BMP signaling), thereby promoting neural tissue formation and inhibiting epidermal differentiation in ectodermal explants. Knockdown of Znf281 reduces expression of neural markers, establishing a required role in early neural development via modulation of BMP signaling. Xenopus embryo overexpression and morpholino knockdown, pSmad1/5/8 Western blot, neural/epidermal marker expression analysis Development, growth & differentiation Medium 41536077

Source papers

Stage 0 corpus · 39 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition. The EMBO journal 154 24185900
2019 CircAGFG1 sponges miR-203 to promote EMT and metastasis of non-small-cell lung cancer by upregulating ZNF281 expression. Thoracic cancer 49 31243884
2020 lncRNA UCA1 Contributes to 5-Fluorouracil Resistance of Colorectal Cancer Cells Through miR-23b-3p/ZNF281 Axis. OncoTargets and therapy 44 32801774
2014 ZNF281/ZBP-99: a new player in epithelial-mesenchymal transition, stemness, and cancer. Journal of molecular medicine (Berlin, Germany) 43 24838609
2015 ZNF281 contributes to the DNA damage response by controlling the expression of XRCC2 and XRCC4. Oncogene 39 26300006
2019 ZNF281 Regulates Cell Proliferation, Migration and Invasion in Colorectal Cancer through Wnt/β-Catenin Signaling. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 33 31112017
2022 ZNF281 drives hepatocyte senescence in alcoholic liver disease by reducing HK2-stabilized PINK1/Parkin-mediated mitophagy. Cell proliferation 28 36514923
2024 tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis. Acta pharmacologica Sinica 27 38286833
2019 ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining. Oncogene 27 31570788
2018 Transcription Factor ZNF281: A Novel Player in Intestinal Inflammation and Fibrosis. Frontiers in immunology 27 30619271
2017 ZNF281 Promotes Growth and Invasion of Pancreatic Cancer Cells by Activating Wnt/β-Catenin Signaling. Digestive diseases and sciences 23 28523575
2012 ZNF281 knockdown induced osteogenic differentiation of human multipotent stem cells in vivo and in vitro. Cell transplantation 23 22963690
2018 Novel lncRNA-ZNF281 regulates cell growth, stemness and invasion of glioma stem-like U251s cells. Neoplasma 22 30509101
2023 ZNF281 inhibits mitochondrial biogenesis to facilitate metastasis of hepatocellular carcinoma. Cell death discovery 21 37880213
2020 ZNF281-miR-543 Feedback Loop Regulates Transforming Growth Factor-β-Induced Breast Cancer Metastasis. Molecular therapy. Nucleic acids 20 32512343
2022 ZNF281 Promotes Colon Fibroblast Activation in TGFβ1-Induced Gut Fibrosis. International journal of molecular sciences 18 36142169
2021 ZNF-281 as the Potential Diagnostic Marker of Oral Squamous Cell Carcinoma. Cancers 18 34071380
2022 Inhibition of the transcription factor ZNF281 by SUFU to suppress tumor cell migration. Cell death and differentiation 15 36220888
2017 GSK-3β phosphorylation-dependent degradation of ZNF281 by β-TrCP2 suppresses colorectal cancer progression. Oncotarget 15 29179460
2019 Expression of zinc finger transcription factors (ZNF143 and ZNF281) in serous borderline ovarian tumors and low-grade ovarian cancers. Journal of ovarian research 13 30885238
2019 ZNF281/Zfp281 is a target of miR-1 and counteracts muscle differentiation. Molecular oncology 12 31782884
2020 Circular RNA hsa_circ_0008003 facilitates tumorigenesis and development of non-small cell lung carcinoma via modulating miR-488/ZNF281 axis. Journal of cellular and molecular medicine 11 33320427
2020 Long non-coding RNA-ZNF281 upregulates PTEN expression via downregulation of microRNA-221 in non-small cell lung cancer. Oncology letters 10 32782613
2019 Zfp281 (ZBP-99) plays a functionally redundant role with Zfp148 (ZBP-89) during erythroid development. Blood advances 9 31455666
2023 Multi-functional gene ZNF281 identified as a molecular biomarker in soft tissue regeneration and pan-cancer progression. Frontiers in genetics 8 36685971
2023 Inhibition of Annexin A10 Contributes to ZNF281 Mediated Aggressiveness of Hepatocellular Carcinoma. Journal of hepatocellular carcinoma 8 37041757
2020 LncRNA-ZNF281 Interacts with miR-539 to Promote Hepatocellular Carcinoma Cell Invasion and Migration. Cancer biotherapy & radiopharmaceuticals 7 32073896
2024 Identification and validation of the role of ZNF281 in 5-fluorouracil chemotherapy of gastric cancer. Journal of cancer research and clinical oncology 6 38880820
2020 Long non-coding RNA-ZNF281 promotes cancer cell migration and invasion in gastric cancer via downregulation of microRNA-124. Oncology letters 6 32194679
2021 Cervical carcinoma progression is aggravated by lncRNA ZNF281 by binding KLF15. European review for medical and pharmacological sciences 5 34604953
2024 Comparative single-cell transcriptomic analysis across tissues of aging primates reveals specific autologous activation of ZNF281 to mitigate oxidative stress in cornea. Aging cell 4 39254179
2024 Inhibition of ZFP281/ZNF281-RIPK1/RIPK3/MLKL signaling in hepatocytes by pterostilbene relieves hepatic lipometabolic disorder and inflammation in non-alcoholic steatohepatitis. International immunopharmacology 4 39724734
2023 Expression of ZNF281 in colorectal cancer correlates with response to radiotherapy and survival. Annals of medicine 4 37939252
2021 Upregulation of lnc-ZNF281 Inhibits the Progression of Glioma via the AKT/GSK-3β/β-Catenin Signaling Pathway. Journal of immunology research 2 34056009
2024 ZNF281 Facilitates the Invasion of Cervical Cancer Cell Both In Vivo and In Vitro †. Cancers 1 39518154
2026 The Zinc Finger Protein Znf281 Is Essential for the Formation of Neural Tissue in Xenopus Embryos. Development, growth & differentiation 0 41536077
2026 Selective translation of ZNF281 as part of the integrated stress response system has therapeutic relevance for cardio-oncology. Science translational medicine 0 41984928
2025 Long noncoding RNA MATN1-AS1 contributes to oxaliplatin resistance of gastric cancer cells through miR-518b/ZNF281 axis. Naunyn-Schmiedeberg's archives of pharmacology 0 40072551
2025 Gene and metabolite changes triggered by downregulation of JUNB and ZNF281 in idiopathic pulmonary arterial hypertension: potential mechanisms revealed by multi-omics study. Translational pediatrics 0 41216437

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