Affinage

ZNF281

Zinc finger protein 281 · UniProt Q9Y2X9

Length
895 aa
Mass
96.9 kDa
Annotated
2026-04-28
39 papers in source corpus 19 papers cited in narrative 20 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ZNF281 is a Krüppel-type zinc-finger transcription factor that operates as a multifunctional transcriptional regulator governing epithelial-mesenchymal transition, DNA damage repair, mitochondrial biogenesis, and cellular differentiation. It directly binds GC-rich promoter elements to activate SNAIL and ZEB1 (driving EMT) or repress tumor suppressors such as ANXA10 by recruiting the NuRD co-repressor complex (HDAC1/MTA1), and it represses mitochondrial biogenesis factors TFAM, NRF1, and PGC-1α through direct promoter binding and physical interaction with NRF1 and PGC-1α (PMID:24185900, PMID:37041757, PMID:37880213). ZNF281 is rapidly recruited to DNA double-strand breaks in a PARP-dependent manner, where it physically interacts with XRCC4 via its zinc-finger domain to promote NHEJ, and it transcriptionally activates both XRCC2 and XRCC4 (PMID:31570788, PMID:26300006). Its protein stability is controlled by GSK-3β-mediated phosphorylation at S638, which triggers β-TrCP2-dependent ubiquitination and degradation, while SUFU sequesters ZNF281 in the cytoplasm by masking its nuclear localization signal; under chemotherapeutic stress, selective translational upregulation of ZNF281 in cardiomyocytes mediates drug-induced cardiotoxicity, as demonstrated by complete resistance to anthracycline injury in cardiomyocyte-specific ZNF281-deficient mice (PMID:29179460, PMID:36220888, PMID:41984928).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 2012 Medium

    Establishing ZNF281 as a transcriptional regulator of β-catenin that controls the balance between stem cell proliferation and differentiation resolved the question of whether ZNF281 functions beyond sequence-specific DNA binding.

    Evidence ChIP on β-CATENIN promoter, gain/loss-of-function in human multipotent stem cells with in vivo subcutaneous implantation

    PMID:22963690

    Open questions at the time
    • Direct binding motif on the β-catenin promoter not mapped at nucleotide resolution
    • Whether ZNF281 activates or represses β-catenin transcription context-dependently was unclear
  2. 2013 High

    Identification of a SNAIL–ZNF281–miR-34a coherent feed-forward loop established ZNF281 as a central EMT-inducing transcription factor in colorectal cancer, resolving how p53 loss amplifies EMT programs.

    Evidence ChIP, luciferase reporters, miRNA target validation, gain/loss-of-function in CRC cells, mouse metastasis model

    PMID:24185900

    Open questions at the time
    • Whether ZNF281 alone is sufficient for EMT without SNAIL co-expression
    • Genome-wide direct target repertoire of ZNF281 was not defined
  3. 2015 High

    Demonstration that ZNF281 directly transactivates DNA repair genes XRCC2 and XRCC4 established a new non-EMT function: transcriptional facilitation of DNA damage repair.

    Evidence ChIP on XRCC2/XRCC4 promoters, luciferase reporters, siRNA knockdown with comet assay under etoposide

    PMID:26300006

    Open questions at the time
    • Whether ZNF281 regulates other DDR pathway genes beyond XRCC2/4
    • No structural basis for promoter selectivity
  4. 2017 High

    Discovery that GSK-3β phosphorylates ZNF281 at S638 to trigger β-TrCP2-mediated ubiquitination and degradation revealed the primary post-translational control mechanism for ZNF281 protein levels.

    Evidence In vitro kinase assay, S638A mutagenesis, co-IP with β-TrCP2, ubiquitination assay in CRC cells

    PMID:29179460

    Open questions at the time
    • Whether other kinases or phospho-sites regulate ZNF281 stability in different tissues
    • Physiological signals upstream of GSK-3β that modulate ZNF281 turnover
  5. 2017 Medium

    Showing that ZNF281 physically binds β-catenin and reduces its polyubiquitination connected ZNF281 to Wnt pathway activation at the protein level, beyond transcriptional regulation of β-catenin.

    Evidence Co-IP, Topflash luciferase assay, ectopic expression/knockdown in pancreatic cancer cells

    PMID:28523575

    Open questions at the time
    • Precise domain on ZNF281 mediating β-catenin interaction not mapped
    • Mechanism by which ZNF281 blocks β-catenin ubiquitination unresolved
  6. 2019 High

    Live-cell imaging showing ZNF281 recruitment to double-strand breaks within seconds, dependent on PARP and its zinc-finger domain, and its physical interaction with XRCC4 to promote NHEJ, established ZNF281 as a direct participant—not just a transcriptional regulator—in DNA repair.

    Evidence Laser micro-irradiation, FRAP, co-IP with XRCC4, NHEJ reporter assay, PARP inhibitor treatment

    PMID:31570788

    Open questions at the time
    • Whether ZNF281 also participates in homologous recombination at damage sites
    • Structural basis for PARP-dependent recruitment unknown
  7. 2019 High

    Identification of Zfp281 as a GATA1 co-factor at erythroid gene promoters extended ZNF281 function to hematopoietic lineage specification, showing it is required for normal erythroid maturation.

    Evidence Reciprocal co-IP, ChIP-seq, conditional knockout mouse model with erythroid maturation block

    PMID:31455666

    Open questions at the time
    • Whether ZNF281 cooperates with GATA1 as an activator or repressor at specific loci
    • Redundancy with Zfp148 not fully delineated
  8. 2022 High

    Demonstrating that SUFU sequesters ZNF281 in the cytoplasm by masking its NLS revealed a Hedgehog-independent mechanism that spatially limits ZNF281 transcriptional activity, controlling both migration and DDR gene activation.

    Evidence Co-IP, subcellular fractionation, NLS mutagenesis, migration assays, in vivo tumor model

    PMID:36220888

    Open questions at the time
    • Signals that release ZNF281 from SUFU sequestration not identified
    • Whether SUFU–ZNF281 interaction is regulated during DNA damage
  9. 2022 High

    Identification of a specific GC-rich binding motif (5'-GGCGGCGGGCGG-3') on the HK2 promoter through which ZNF281 represses HK2 transcription linked ZNF281 to metabolic regulation and mitophagy control.

    Evidence ChIP with defined motif, promoter reporter, siRNA knockdown, AAV-shRNA in vivo, mitophagy/senescence readouts

    PMID:36514923

    Open questions at the time
    • Genome-wide prevalence and functionality of this motif at other ZNF281 targets unknown
    • Whether ZNF281 repression of HK2 operates in non-hepatic tissues
  10. 2023 High

    Discovery that ZNF281 physically interacts with NRF1 and PGC-1α and represses TFAM/TFB1M/TFB2M established ZNF281 as a negative regulator of mitochondrial biogenesis, linking its EMT-promoting role to metabolic reprogramming in hepatocellular carcinoma.

    Evidence Co-IP, ChIP on TFAM/TFB1M/TFB2M promoters, RNA-seq, OCR measurement, metabolomics, knockdown/rescue

    PMID:37880213

    Open questions at the time
    • Whether ZNF281 globally rewires oxidative phosphorylation or selectively targets mitochondrial transcription
    • Applicability beyond HCC not tested
  11. 2023 High

    Showing that ZNF281 recruits the NuRD complex (HDAC1/MTA1) to the ANXA10 promoter to silence this tumor suppressor revealed the co-repressor mechanism by which ZNF281 drives HCC invasion.

    Evidence ChIP, co-IP identifying HDAC1 and MTA1, RNA-seq, siRNA rescue of ANXA10, pulmonary metastasis model

    PMID:37041757

    Open questions at the time
    • Whether NuRD recruitment is a general mechanism at all ZNF281-repressed loci or specific to ANXA10
    • Structural basis of ZNF281–NuRD interaction unknown
  12. 2024 Medium

    Linking ZNF281 to RIPK1/RIPK3/MLKL necroptotic signaling in hepatocytes under lipotoxic stress, and demonstrating prevention of NASH by hepatocyte-specific Zfp281 deletion, expanded ZNF281 function to inflammatory cell death in metabolic liver disease.

    Evidence Hepatocyte-specific Zfp281 KO mice, Western blot, metabolic phenotyping, histology

    PMID:39724734

    Open questions at the time
    • Direct transcriptional mechanism linking ZNF281 to RIPK1 upregulation not established
    • Whether ZNF281 drives necroptosis in tissues beyond liver
  13. 2026 High

    Demonstrating that chemotherapeutic agents selectively upregulate ZNF281 translation in cardiomyocytes via the integrated stress response, and that cardiomyocyte-specific ZNF281 deficiency confers complete resistance to anthracycline cardiotoxicity, identified ZNF281 as a druggable mediator of chemotherapy-induced heart injury.

    Evidence Cardiomyocyte-specific conditional KO and overexpression mice, ZNF281 small-molecule inhibitor (ZIM), patient myocardial tissue analysis

    PMID:41984928

    Open questions at the time
    • Downstream transcriptional targets of ZNF281 in cardiomyocytes that execute cell death not identified
    • Whether ZIM has off-target effects in tumors
  14. 2026 Medium

    Showing that Znf281 reduces phosphorylated Smad1/5/8 to promote neural induction in Xenopus extended ZNF281 function to BMP pathway antagonism during vertebrate neural development.

    Evidence Xenopus overexpression and morpholino knockdown, ectodermal explant assays, Western blot for pSmad1/5/8

    PMID:41536077

    Open questions at the time
    • Mechanism by which ZNF281 reduces pSmad1/5/8 (direct or indirect) not elucidated
    • Relevance to mammalian neural development not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • The genome-wide direct target repertoire, the structural basis for GC-rich DNA recognition and co-repressor recruitment, and the tissue-specific rules governing whether ZNF281 activates or represses transcription remain unresolved.
  • No crystal or cryo-EM structure of ZNF281 zinc-finger domain bound to DNA
  • No genome-wide CUT&RUN or equivalent in matched activation/repression contexts
  • Integrated model of how post-translational modifications (phosphorylation, ubiquitination, SUFU sequestration) coordinately tune ZNF281 activity is lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 8 GO:0003677 DNA binding 6
Localization
GO:0005634 nucleus 6 GO:0005829 cytosol 1
Pathway
R-HSA-74160 Gene expression (Transcription) 6 R-HSA-162582 Signal Transduction 3 R-HSA-1266738 Developmental Biology 2 R-HSA-5357801 Programmed Cell Death 2 R-HSA-73894 DNA Repair 2 R-HSA-1852241 Organelle biogenesis and maintenance 1 R-HSA-4839726 Chromatin organization 1
Partners
CTNNB1GATA1HDAC1MTA1NRF1SNAI1SUFUXRCC4
Complex memberships
NuRD

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2013 ZNF281 expression is directly induced by SNAIL at the transcriptional level and repressed by miR-34a/b/c (which is itself repressed by SNAIL), forming a coherent feed-forward loop. ZNF281 in turn directly activates SNAIL transcription, creating a regulatory circuit controlling EMT. p53 activation represses ZNF281 via miR-34a. Luciferase reporter assays, ChIP, miRNA target validation, gain/loss-of-function in CRC cells, mouse metastasis model The EMBO journal High 24185900
2013 ZNF281 directly activates SNAIL transcription and induces EMT markers, increases β-catenin activity, and promotes stemness marker expression (LGR5, CD133) in colorectal cancer cells. c-MYC induces ZNF281 protein expression in a SNAIL-dependent manner. Ectopic expression, knockdown, luciferase assays, ChIP, sphere formation, mouse lung metastasis model The EMBO journal High 24185900
2014 ZNF281 physically interacts with the pluripotency transcription factors NANOG, OCT4, SOX2, and c-MYC. Co-immunoprecipitation (reported in review citing experimental data) Journal of molecular medicine (Berlin, Germany) Medium 24838609
2015 ZNF281 transcriptionally activates XRCC2 (homologous recombination) and XRCC4 (NHEJ) through direct DNA binding at their promoters, contributing to the cellular DNA damage response. This is dependent on its DNA-binding domain. Luciferase reporter assays, ChIP (chromatin immunoprecipitation), siRNA knockdown with comet assay for DNA repair, genotoxic stress (etoposide) treatment Oncogene High 26300006
2017 GSK-3β (but not GSK-3α) phosphorylates ZNF281 at a consensus TSGEHS motif (S638), which promotes ZNF281 interaction with the E3 ligase β-TrCP2, leading to ubiquitination and proteasomal degradation of ZNF281. A ZNF281-S638A mutant is resistant to this degradation. ZNF281 also transcriptionally represses β-TrCP2, forming a negative feedback loop. In vitro kinase assay, co-immunoprecipitation, ubiquitination assay, site-directed mutagenesis (S638A), Western blot, CRC cell lines Oncotarget High 29179460
2017 ZNF281 promotes pancreatic cancer cell proliferation and invasion by directly binding β-catenin and decreasing its polyubiquitination, thereby activating Wnt/β-catenin signaling and downstream gene expression. Immunoprecipitation, Western blot, Topflash luciferase assay, ectopic expression/knockdown Digestive diseases and sciences Medium 28523575
2019 ZNF281 is rapidly recruited to DNA double-strand break sites (within seconds of damage) via a mechanism dependent on its DNA-binding domain and, at least in part, on PARP activity. ZNF281 binds XRCC4 through its zinc-finger domain and facilitates XRCC4 recruitment to damage sites, promoting efficient NHEJ repair. Live-cell imaging, FRAP, laser micro-irradiation, co-immunoprecipitation, siRNA knockdown, NHEJ repair assay, PARP inhibitor treatment Oncogene High 31570788
2019 Zfp281 (mouse ortholog of ZNF281) physically associates with the master erythroid transcription factor GATA1, co-occupies chromatin sites with GATA1 and Zfp148, and regulates a common set of genes required for erythroid cell differentiation. Combined deficiency of Zfp148 and Zfp281 causes a marked erythroid maturation block. Co-immunoprecipitation, ChIP-seq, conditional knockout mouse model, knockdown studies Blood advances High 31455666
2019 ZNF281 knockdown in colorectal cancer cells suppresses cell proliferation, migration, and invasion by inhibiting the Wnt/β-catenin pathway. siRNA knockdown, Transwell/wound healing assay, Western blot for Wnt/β-catenin pathway components Cellular physiology and biochemistry Medium 31112017
2019 ZNF281/Zfp281 inhibits skeletal muscle differentiation induced by miR-1 and is a direct target of miR-1. Multiple miR binding sites in the 3'UTR of ZNF281/Zfp281 are functional for post-transcriptional regulation during differentiation. 3'UTR reporter assays, miR-1 gain/loss-of-function, differentiation assays in muscle cell lines Molecular oncology Medium 31782884
2020 ZNF281 transactivates the EMT-related transcription factors ZEB1 and SNAIL to promote TGF-β-induced breast cancer metastasis. ZEB1 and SNAIL in turn transcriptionally suppress miR-543, which targets ZNF281, forming a ZNF281–miR-543 feedback loop. Luciferase reporter assays, ChIP, gain/loss-of-function, in vitro and in vivo metastasis assays Molecular therapy. Nucleic acids Medium 32512343
2012 ZNF281 binds to the promoter region of β-CATENIN and transcriptionally regulates it. Knockdown of ZNF281 in human multipotent stem cells results in spontaneous osteochondrogenic differentiation, while overexpression promotes proliferation. ChIP assay, gain/loss-of-function, in vivo subcutaneous implantation with β-TCP, molecular markers for differentiation Cell transplantation Medium 22963690
2022 SUFU binds ZNF281 and masks its nuclear localization signal, causing cytoplasmic retention of ZNF281 and thereby inhibiting ZNF281-mediated tumor cell migration and DNA damage repair gene activation. This is a Hedgehog-independent function of SUFU. Co-immunoprecipitation, subcellular fractionation/localization studies, NLS mutagenesis, migration assays, in vivo tumor model Cell death and differentiation High 36220888
2022 ZNF281 directly binds to the 5'-GGCGGCGGGCGG-3' motif within the HK2 promoter to transcriptionally repress HK2 expression, thereby reducing HK2-stabilized PINK1/Parkin-mediated mitophagy and driving ethanol-induced hepatocyte senescence. ChIP assay, promoter reporter assay, siRNA knockdown, adeno-associated virus (AAV) shRNA in vivo, mitophagy/senescence readouts Cell proliferation High 36514923
2023 ZNF281 suppresses transcription of the mitochondrial biogenesis factors TFAM, NRF1, and PGC-1α. ZNF281 also physically interacts with NRF1 and PGC-1α and is recruited to the promoters of TFAM, TFB1M, and TFB2M to repress their expression, thereby inhibiting mitochondrial biogenesis and facilitating HCC metastasis. Co-immunoprecipitation, ChIP assay, RNA-seq, knockdown/rescue experiments, OCR measurement, metabolomics Cell death discovery High 37880213
2023 ZNF281 recruits components of the NuRD complex (including HDAC1 and MTA1) to the ANXA10 promoter via direct binding to ZNF281 recognition sites, transcriptionally repressing the tumor suppressor ANXA10 and thereby promoting HCC invasion and metastasis. Knockdown of HDAC1 or MTA1 releases ANXA10 from repression and reverses ZNF281-driven EMT. ChIP assay, co-immunoprecipitation, RNA-seq, siRNA knockdown, transwell/migration assays, pulmonary metastasis model Journal of hepatocellular carcinoma High 37041757
2024 ZNF281 upregulates RIPK1/RIPK3/MLKL necroptotic signaling in hepatocytes under lipotoxic stress. Activated MLKL translocates to mitochondrial membrane disrupting fatty acid β-oxidation and to the plasma membrane triggering lytic cell death, thereby promoting NASH progression. Hepatocyte-specific Zfp281 deficiency prevents NASH in mice. Hepatocyte-specific Zfp281 knockout mice, Western blot, immunofluorescence, metabolic phenotyping, histology, molecular biology International immunopharmacology Medium 39724734
2024 ZNF281 forms a positive feedback loop with FOXO3 in corneal cells to sense elevated ROS and mitigate oxidative stress, potentially by regulating mitochondrial respiratory chain components and superoxide dismutase (SOD) expression. ZNF281 overexpression in MSCs prevents cellular senescence. Single-cell transcriptomics, overexpression experiments, immunofluorescence, functional senescence assays Aging cell Low 39254179
2026 Znf281 reduces phosphorylated Smad1/5/8 levels (downstream effectors of BMP signaling) to promote neural tissue formation in Xenopus embryos. Znf281 overexpression induces neural tissue with anterior-posterior patterning and inhibits epidermal differentiation; knockdown reduces expression of neural markers. Xenopus gain/loss-of-function (overexpression, morpholino knockdown), ectodermal explant assays, Western blot for pSmad1/5/8, in situ hybridization for neural markers Development, growth & differentiation Medium 41536077
2026 Multiple classes of anticancer agents (intercalating/alkylating agents, tyrosine kinase inhibitors, receptor inhibitors) converge to increase selective translational upregulation of ZNF281 in cardiomyocytes as part of the integrated stress response. Cardiomyocyte-specific ZNF281-deficient mice are completely resistant to anthracycline-induced cardiotoxicity, whereas cardiomyocyte-specific ZNF281-overexpressing mice develop cardiotoxicity features. Cardiomyocyte-specific conditional knockout and overexpression mouse models, pharmacological small-molecule inhibitor (ZIM), in vivo tumor/metastasis model, patient myocardial tissue analysis Science translational medicine High 41984928

Source papers

Stage 0 corpus · 39 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2013 SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition. The EMBO journal 152 24185900
2019 CircAGFG1 sponges miR-203 to promote EMT and metastasis of non-small-cell lung cancer by upregulating ZNF281 expression. Thoracic cancer 49 31243884
2020 lncRNA UCA1 Contributes to 5-Fluorouracil Resistance of Colorectal Cancer Cells Through miR-23b-3p/ZNF281 Axis. OncoTargets and therapy 44 32801774
2014 ZNF281/ZBP-99: a new player in epithelial-mesenchymal transition, stemness, and cancer. Journal of molecular medicine (Berlin, Germany) 42 24838609
2015 ZNF281 contributes to the DNA damage response by controlling the expression of XRCC2 and XRCC4. Oncogene 38 26300006
2019 ZNF281 Regulates Cell Proliferation, Migration and Invasion in Colorectal Cancer through Wnt/β-Catenin Signaling. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 31 31112017
2022 ZNF281 drives hepatocyte senescence in alcoholic liver disease by reducing HK2-stabilized PINK1/Parkin-mediated mitophagy. Cell proliferation 28 36514923
2019 ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining. Oncogene 27 31570788
2018 Transcription Factor ZNF281: A Novel Player in Intestinal Inflammation and Fibrosis. Frontiers in immunology 26 30619271
2024 tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis. Acta pharmacologica Sinica 25 38286833
2017 ZNF281 Promotes Growth and Invasion of Pancreatic Cancer Cells by Activating Wnt/β-Catenin Signaling. Digestive diseases and sciences 23 28523575
2012 ZNF281 knockdown induced osteogenic differentiation of human multipotent stem cells in vivo and in vitro. Cell transplantation 23 22963690
2018 Novel lncRNA-ZNF281 regulates cell growth, stemness and invasion of glioma stem-like U251s cells. Neoplasma 22 30509101
2023 ZNF281 inhibits mitochondrial biogenesis to facilitate metastasis of hepatocellular carcinoma. Cell death discovery 21 37880213
2020 ZNF281-miR-543 Feedback Loop Regulates Transforming Growth Factor-β-Induced Breast Cancer Metastasis. Molecular therapy. Nucleic acids 20 32512343
2021 ZNF-281 as the Potential Diagnostic Marker of Oral Squamous Cell Carcinoma. Cancers 18 34071380
2022 ZNF281 Promotes Colon Fibroblast Activation in TGFβ1-Induced Gut Fibrosis. International journal of molecular sciences 17 36142169
2022 Inhibition of the transcription factor ZNF281 by SUFU to suppress tumor cell migration. Cell death and differentiation 15 36220888
2017 GSK-3β phosphorylation-dependent degradation of ZNF281 by β-TrCP2 suppresses colorectal cancer progression. Oncotarget 15 29179460
2019 Expression of zinc finger transcription factors (ZNF143 and ZNF281) in serous borderline ovarian tumors and low-grade ovarian cancers. Journal of ovarian research 13 30885238
2019 ZNF281/Zfp281 is a target of miR-1 and counteracts muscle differentiation. Molecular oncology 12 31782884
2020 Circular RNA hsa_circ_0008003 facilitates tumorigenesis and development of non-small cell lung carcinoma via modulating miR-488/ZNF281 axis. Journal of cellular and molecular medicine 11 33320427
2020 Long non-coding RNA-ZNF281 upregulates PTEN expression via downregulation of microRNA-221 in non-small cell lung cancer. Oncology letters 10 32782613
2019 Zfp281 (ZBP-99) plays a functionally redundant role with Zfp148 (ZBP-89) during erythroid development. Blood advances 9 31455666
2023 Inhibition of Annexin A10 Contributes to ZNF281 Mediated Aggressiveness of Hepatocellular Carcinoma. Journal of hepatocellular carcinoma 8 37041757
2020 LncRNA-ZNF281 Interacts with miR-539 to Promote Hepatocellular Carcinoma Cell Invasion and Migration. Cancer biotherapy & radiopharmaceuticals 8 32073896
2023 Multi-functional gene ZNF281 identified as a molecular biomarker in soft tissue regeneration and pan-cancer progression. Frontiers in genetics 7 36685971
2024 Identification and validation of the role of ZNF281 in 5-fluorouracil chemotherapy of gastric cancer. Journal of cancer research and clinical oncology 6 38880820
2020 Long non-coding RNA-ZNF281 promotes cancer cell migration and invasion in gastric cancer via downregulation of microRNA-124. Oncology letters 6 32194679
2021 Cervical carcinoma progression is aggravated by lncRNA ZNF281 by binding KLF15. European review for medical and pharmacological sciences 5 34604953
2023 Expression of ZNF281 in colorectal cancer correlates with response to radiotherapy and survival. Annals of medicine 4 37939252
2024 Comparative single-cell transcriptomic analysis across tissues of aging primates reveals specific autologous activation of ZNF281 to mitigate oxidative stress in cornea. Aging cell 3 39254179
2024 Inhibition of ZFP281/ZNF281-RIPK1/RIPK3/MLKL signaling in hepatocytes by pterostilbene relieves hepatic lipometabolic disorder and inflammation in non-alcoholic steatohepatitis. International immunopharmacology 2 39724734
2021 Upregulation of lnc-ZNF281 Inhibits the Progression of Glioma via the AKT/GSK-3β/β-Catenin Signaling Pathway. Journal of immunology research 2 34056009
2024 ZNF281 Facilitates the Invasion of Cervical Cancer Cell Both In Vivo and In Vitro †. Cancers 1 39518154
2026 The Zinc Finger Protein Znf281 Is Essential for the Formation of Neural Tissue in Xenopus Embryos. Development, growth & differentiation 0 41536077
2026 Selective translation of ZNF281 as part of the integrated stress response system has therapeutic relevance for cardio-oncology. Science translational medicine 0 41984928
2025 Long noncoding RNA MATN1-AS1 contributes to oxaliplatin resistance of gastric cancer cells through miR-518b/ZNF281 axis. Naunyn-Schmiedeberg's archives of pharmacology 0 40072551
2025 Gene and metabolite changes triggered by downregulation of JUNB and ZNF281 in idiopathic pulmonary arterial hypertension: potential mechanisms revealed by multi-omics study. Translational pediatrics 0 41216437