Affinage

ZBTB16

Zinc finger and BTB domain-containing protein 16 · UniProt Q05516

Length
673 aa
Mass
74.3 kDa
Annotated
2026-06-11
100 papers in source corpus 49 papers cited in narrative 49 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

ZBTB16 (PLZF) is a BTB/POZ-zinc finger transcription factor that governs stem/progenitor cell fate decisions across germline, hematopoietic, lymphoid, and skeletal lineages by binding defined DNA response elements and acting predominantly as a sequence-specific transcriptional repressor (PMID:12802276, PMID:17664282, PMID:27068105). Its BTB/POZ domain forms an obligate homodimer presenting a corepressor-binding groove (PMID:9770450) and is required for DNA binding as a high-molecular-weight complex (PMID:10497277) and for recruitment of corepressor machinery including SMRT, mSin3A, and HDAC1 (PMID:9256429, PMID:9765306); through these complexes PLZF silences targets such as Kit, cyclin A2, Hox genes, CRABPI, and differentiation-promoting factors (Stra8, Sohlh2, Dmrt1, GFI-1, C/EBPalpha, ID2) to restrain proliferation and differentiation (PMID:10023668, PMID:10835630, PMID:18000064, PMID:17664282, PMID:19723763, PMID:31541472). In spermatogonia PLZF is intrinsically required for stem cell self-renewal, repressing Kit while being functionally counter-balanced by SALL4, with which it shares thousands of genomic targets (PMID:15156142, PMID:22385656, PMID:27068105); in innate and innate-like lymphocytes a Runx1-dependent enhancer drives PLZF to program effector genes including c-Maf (PMID:23267359, PMID:27325774, PMID:29038474), and in hematopoietic stem cells PLZF maintains the lymphoid-biased, quiescent state (PMID:26941402). Beyond transcription, PLZF serves as the substrate receptor of a ZBTB16-Cullin3-Roc1 E3 ubiquitin ligase that degrades Atg14L to suppress autophagy downstream of GPCR signaling (PMID:25821988), promotes SUMOylation of the inflammasome adaptor ASC (PMID:38123560), and in immune cells assembles an HDAC3/NF-kB p50 repressor complex after CaMK2-HAT1-mediated acetylation to limit inflammatory cytokine output (PMID:25865065). PLZF activity is tuned by post-translational modification and protein stability, including ERK-driven nuclear export (PMID:19723763), SUMO/ubiquitin antagonism at K242 (PMID:18348865), and degradation by CRL4(CRBN) via its first and third zinc fingers, the molecular basis of thalidomide teratogenicity in skeletal patterning (PMID:33470442). Consistent with its developmental roles, Plzf-null mice show homeotic skeletal transformations and limb patterning defects (PMID:10835630, PMID:16015334). The oncogenic PLZF-RARalpha and reciprocal RARalpha-PLZF fusions of acute promyelocytic leukemia retain the PLZF corepressor and Polycomb/PRC1 (Bmi-1) recruitment functions, conferring retinoic-acid-resistant repression (PMID:9462740, PMID:19451220, PMID:23898169).

Mechanistic history

Synthesis pass · year-by-year structured walk · 22 steps
  1. 1997 High

    Established the biochemical basis of PLZF-mediated repression by identifying SMRT corepressor recruitment through the POZ/BTB domain, and showed this interaction persists in the leukemogenic PLZF-RARalpha fusion.

    Evidence Co-immunoprecipitation, yeast two-hybrid, and domain mapping

    PMID:9256429

    Open questions at the time
    • Did not resolve which target genes are repressed in vivo
    • Stoichiometry and additional corepressor components not defined
  2. 1998 High

    Extended the corepressor model to mSin3A and HDAC1 and crystallographically defined the BTB/POZ domain as an obligate homodimer with a corepressor-binding groove, explaining how PLZF nucleates HDAC complexes at chromatin.

    Evidence Co-IP/GST pulldown plus 1.9 A X-ray crystallography with nuclear localization assays

    PMID:9462740 PMID:9765306 PMID:9770450

    Open questions at the time
    • Identity of the peptide bound in the dimer-interface groove not directly demonstrated
    • Distinction between native and PLZF-RARalpha corepressor interfaces only partially mapped
  3. 1999 Medium

    Linked PLZF DNA binding to a large multiprotein complex requiring the POZ domain and to cdc2-mediated phosphorylation, introducing post-translational control of its activity.

    Evidence EMSA, co-IP, phosphatase treatment, and reporter/proliferation assays

    PMID:10023668 PMID:10497277

    Open questions at the time
    • Phosphosites not mapped
    • Direct cdc2 phosphorylation of PLZF not reconstituted
  4. 2000 High

    Defined the developmental requirement for Plzf in axial and limb skeletal patterning via regulation of AbdB Hox genes and Bmps, establishing it as a pro-apoptotic, growth-inhibitory factor in vivo.

    Evidence Zfp145 knockout mice with in situ hybridization and skeletal phenotyping

    PMID:10835630

    Open questions at the time
    • Direct vs indirect regulation of Hox genes not fully separated
    • Mechanism of pro-apoptotic action undefined
  5. 2003 High

    Demonstrated direct, sequence-specific PLZF DNA binding at defined response elements (Hoxb2 enhancer) requiring the POZ domain for cooperative occupancy, confirming PLZF as a bona fide site-specific factor.

    Evidence EMSA, mutagenesis, and in vivo chick neural tube reporter assays

    PMID:12802276 PMID:18000064

    Open questions at the time
    • Genome-wide binding landscape still unknown at this stage
    • Cooperating factors at most loci unidentified
  6. 2004 High

    Showed Plzf is cell-autonomously required for spermatogonial stem cell self-renewal, establishing its function in maintaining a tissue stem cell pool.

    Evidence Spermatogonial transplantation, positional cloning of luxoid, and Oct4 co-localization

    PMID:15156142

    Open questions at the time
    • Direct transcriptional targets driving self-renewal not yet identified
  7. 2007 High

    Identified Kit as a direct repression target of PLZF in spermatogonia, providing a concrete molecular mechanism connecting PLZF to the self-renewal-versus-differentiation switch.

    Evidence ChIP, EMSA, promoter mutagenesis, and qRT-PCR in Plzf-null cells

    PMID:17664282

    Open questions at the time
    • Whether Kit derepression alone accounts for the self-renewal defect not established
  8. 2009 Medium

    Defined PLZF as a brake on myeloid progenitor proliferation/differentiation controlled by ERK-driven nuclear export, and identified ID2, GFI-1, C/EBPalpha, and LEF-1 as functional targets.

    Evidence Overexpression/knockdown, ChIP, cytokine stimulation, and ID2 rescue in CD34+ cells

    PMID:19421145 PMID:19723763

    Open questions at the time
    • ERK phosphorylation site on PLZF not mapped
    • Relative contribution of each target gene unresolved
  9. 2009 High

    Showed the oncogenic PLZF-RARalpha fusion stably integrates into PRC1 via Bmi-1, explaining retinoic-acid-resistant Polycomb recruitment and transformation in APL.

    Evidence Co-IP, ChIP, and Bmi-1 depletion functional assays

    PMID:19451220 PMID:9462740

    Open questions at the time
    • Whether native PLZF also uses PRC1 not addressed here
    • Genome-wide PRC1 redistribution not mapped
  10. 2012 High

    Defined a SALL4-PLZF antagonism at chromatin that toggles Kit repression and the self-renewal/differentiation decision in spermatogonia.

    Evidence Co-IP, ChIP, and in vivo genetic loss-of-function in mice

    PMID:22385656

    Open questions at the time
    • Structural basis of mutual chromatin displacement not resolved
  11. 2012 Medium

    Extended PLZF function to innate-like lymphocyte effector programming, placing c-Maf and Id2 downstream as mediators of NKT cytokine output.

    Evidence Microarray and lentiviral rescue in PLZF KO NKT cells

    PMID:23267359

    Open questions at the time
    • Direct vs indirect target status of c-Maf not shown
    • Single rescue gene only partially restores phenotype
  12. 2013 Medium

    Identified multiple layers of PLZF protein-level and pathway-level regulation: SUMO/ubiquitin antagonism at K242 under oxidative stress, USP37-mediated stabilization of the fusion oncoprotein, PKA phosphorylation releasing corepressors, and FOXO3a/PTEN-AKT control of PLZF expression.

    Evidence Mutagenesis, ubiquitination/pulse-chase, phosphorylation assays, ChIP/reporter, and in vivo APL model

    PMID:18348865 PMID:23208507 PMID:23382200 PMID:24339862

    Open questions at the time
    • Interplay among these modifications not integrated
    • Several mechanisms shown in single labs
  13. 2013 Medium

    Revealed a genome-protective role: PLZF represses L1 retrotransposons via directed DNA methylation, with stress releasing repression and impairing spermatogenesis and myelopoiesis.

    Evidence ChIP, bisulfite sequencing, and retrotransposition assays with stress induction

    PMID:23727884

    Open questions at the time
    • DNA methyltransferase recruitment mechanism not defined
    • Single-lab observation
  14. 2015 High

    Demonstrated a non-transcriptional function: PLZF acts as the substrate receptor of a Cullin3-Roc1 E3 ligase that degrades Atg14L to suppress autophagy downstream of GPCR signaling.

    Evidence Co-IP, in vitro ubiquitination/degradation, proteasome inhibition, and GPCR agonist treatment

    PMID:25821988

    Open questions at the time
    • Signal coupling GPCR activation to complex assembly not fully mapped
    • Whether additional substrates exist unknown
  15. 2015 High

    Defined PLZF acetylation by CaMK2-activated HAT1 downstream of TLR/TNF signaling, nucleating an HDAC3/NF-kB p50 repressor complex that dampens inflammatory cytokines, and identified let-7 miRNA control of PLZF directing NKT subset fate.

    Evidence Acetylation/kinase assays with mutagenesis and reconstitution; miRNA target reporter and genetic let-7 models

    PMID:25848867 PMID:25865065

    Open questions at the time
    • Acetyl-site dependence of complex assembly partially characterized
    • Cell-type generality of the NF-kB repressor complex not tested
  16. 2016 High

    Mapped PLZF genome-wide binding in NKT cells and spermatogonia, defining its multilayered transcriptional architecture and extensive target overlap with SALL4.

    Evidence ChIP-seq with microarray/RNA-seq and knockdown in two cell systems

    PMID:27068105 PMID:27325774

    Open questions at the time
    • Direct vs indirect targets within bound gene sets not fully separated
    • Activator vs repressor mode per locus not resolved
  17. 2017 High

    Identified the Runx1-bound enhancer in the Zbtb16 locus as the essential cis-element driving PLZF expression in innate lymphoid lineages, defining how PLZF expression itself is controlled.

    Evidence In vivo CRISPR enhancer deletion, ATAC-seq, and Runx1 ChIP-seq

    PMID:29038474 PMID:30374131

    Open questions at the time
    • Upstream signals activating this enhancer not fully defined
    • Lineage-specific cofactors at the enhancer incomplete
  18. 2018 Medium

    Revealed non-canonical regulation in which EZH2 co-occupies PLZF target loci independently of PRC2 to restrain PLZF's activating function, expanding PLZF beyond a pure repressor.

    Evidence ChIP-seq for PLZF/EZH2/SUZ12/H3K27 marks with EZH2 depletion

    PMID:29425303

    Open questions at the time
    • Mechanism of PRC2-independent EZH2 recruitment unknown
    • Single-lab observation
  19. 2019 High

    Defined a PLZF-driven enhancer-looping mechanism (to NNMT) controlling SAM levels during osteogenesis, and refined its role in restraining EOMES+ spermatogonial stem cell proliferation to prevent exhaustion.

    Evidence ChIP-seq, chromosome conformation capture, knockdown, and lineage tracing/scRNA-seq

    PMID:30672466 PMID:31149899

    Open questions at the time
    • How PLZF selects looping partners not defined
    • Metabolic readout linking NNMT to differentiation correlative
  20. 2020 High

    Established ZBTB16 as a cereblon neosubstrate whose first and third zinc fingers act as structural degrons engaged by CRL4(CRBN) modulators, and showed thalidomide-induced degradation underlies skeletal teratogenicity.

    Evidence Degradation assays with multiple CRBN modulators, domain mapping, and in ovo knockdown/rescue in chicken embryos

    PMID:33206504 PMID:33470442

    Open questions at the time
    • Physiological (drug-independent) ubiquitin ligase controlling ZBTB16 levels not identified
    • Quantitative contribution of ZBTB16 loss to full teratogenic spectrum partial
  21. 2023 High

    Identified a role for nuclear ZBTB16 in promoting ASC SUMOylation to enable inflammasome assembly, with loss reducing inflammatory pathogenesis in a Muckle-Wells model.

    Evidence SUMOylation/co-IP assays with ZBTB16 KO in a constitutively active inflammasome mouse model

    PMID:38123560

    Open questions at the time
    • Whether ZBTB16 acts as a SUMO ligase or scaffold not resolved
    • Relationship to its transcriptional role unclear
  22. 2024 Medium

    Linked ZBTB16 to glucocorticoid-driven cortical neurogenesis, expanding its developmental roles into neural progenitor expansion.

    Evidence Human cerebral organoids and mouse models with ZBTB16 knockdown and Mendelian randomization

    PMID:38442714

    Open questions at the time
    • Direct transcriptional targets in neural progenitors not identified
    • Single-lab study

Open questions

Synthesis pass · forward-looking unresolved questions
  • How PLZF integrates its dual identity as a sequence-specific transcription factor and as an E3-ligase substrate receptor/SUMO-pathway modulator, and what physiological signals govern switching among repression, activation, and protein-degradation functions, remains unresolved.
  • No unified model of context-dependent activator vs repressor choice
  • Physiological E3 ligase regulating endogenous ZBTB16 levels unknown
  • Structural basis of substrate selection by the ZBTB16-Cullin3 complex undetermined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003677 DNA binding 5 GO:0140110 transcription regulator activity 5 GO:0098772 molecular function regulator activity 2 GO:0140096 catalytic activity, acting on a protein 2 GO:0016874 ligase activity 1
Localization
GO:0005634 nucleus 3 GO:0005654 nucleoplasm 2
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-168256 Immune System 4 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-392499 Metabolism of proteins 3 R-HSA-4839726 Chromatin organization 3 R-HSA-1640170 Cell Cycle 2 R-HSA-9612973 Autophagy 1
Partners
BMI1EZH2GATA2HDAC1NCOR2SALL4SIN3AUSP37
Complex memberships
HAT1/HDAC3/NF-kB p50 repressor complexPLZF/SMRT-mSin3A-HDAC corepressor complexPRC1 (Bmi-1, via PLZF-RARalpha fusion)ZBTB16-Cullin3-Roc1 E3 ubiquitin ligase

Evidence

Reading pass · 49 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1997 PLZF interacts with the SMRT corepressor via its POZ/BTB domain; this interaction mediates transcriptional repression and is retained in the PLZF-RARα fusion oncoprotein. Co-immunoprecipitation, yeast two-hybrid, domain mapping Proceedings of the National Academy of Sciences of the United States of America High 9256429
1998 PLZF interacts with mSin3A and histone deacetylase-1 (HDAC1) in addition to SMRT; these corepressor interactions are mediated by distinct interfaces and differ between PLZF and the oncogenic PLZF-RARα chimera, which lacks several corepressor interaction sites present in native PLZF. Co-immunoprecipitation, GST pulldown, domain mapping The Journal of biological chemistry High 9765306
1998 The BTB/POZ domain of PLZF forms an obligate homodimer with an extensive hydrophobic interface; a surface-exposed groove at the dimer interface is lined with conserved residues suggestive of a corepressor peptide-binding site. The BTB domain directs PLZF to a nuclear punctate pattern and interacts with components of the histone deacetylase complex. X-ray crystallography at 1.9 Å resolution, nuclear localization experiments Proceedings of the National Academy of Sciences of the United States of America High 9770450
1998 PLZF-RARα, unlike PML-RARα, forms RA-insensitive corepressor complexes via its PLZF moiety, explaining retinoic acid resistance. HDAC inhibitor TSA combined with RA can overcome the transcriptional repressor activity of both fusion proteins. Transgenic mouse models, co-immunoprecipitation, transcriptional reporter assays, TSA treatment Nature genetics High 9462740
1999 PLZF binds DNA as a high-molecular-weight (~600 kDa) complex whose formation requires the POZ/dimerization domain. PLZF co-immunoprecipitates with cdc2 kinase, is a phosphoprotein, and the PLZF-DNA complex is abolished by phosphatase treatment, suggesting cdc2-mediated phosphorylation modulates PLZF activity. RARα/PLZF does not complex with cdc2. Electrophoretic mobility shift assay, co-immunoprecipitation, biotin-streptavidin pulldown, phosphatase treatment Nucleic acids research Medium 10497277
1999 PLZF binds and represses the cyclin A2 promoter, leading to growth suppression; expression of cyclin A2 reverts PLZF-mediated growth suppression in myeloid cells. The reciprocal fusion RARα-PLZF activates cyclin A2 transcription. Reporter gene assay, stable transfection, proliferation assay, promoter binding Oncogene Medium 10023668
2000 Plzf acts as a growth-inhibitory and pro-apoptotic factor in the limb bud and regulates expression of AbdB Hox genes (Hoxd10-13) and Bmps in the developing limb; Zfp145−/− mice exhibit homeotic transformations of anterior skeletal elements and alterations in Hox gene expression. Knockout mouse generation, in situ hybridization, gene expression analysis Nature genetics High 10835630
2002 PLZF physically interacts with GATA1 (co-immunoprecipitation in TF1 cells); co-expression of PLZF and GATA1 results in enhanced upregulation of megakaryocytic markers compared to either factor alone, suggesting a functional transcriptional complex. PLZF also activates the thrombopoietin receptor (TpoR) promoter through a direct PLZF DNA-binding site. Co-immunoprecipitation, reporter gene assay, deletion construct analysis, stable transfection Oncogene Medium 12242665
2002 PLZF interacts with GATA-2 via the zinc finger region of GATA-2; this interaction modifies GATA-2 transactivation capacity. PLZF-RARα also associates with GATA-2, making GATA-dependent transcription responsive to RA plus TSA. Yeast two-hybrid, co-immunoprecipitation, domain mapping, transcriptional reporter assay Blood Medium 11964310
2002 C. elegans EOR-1 (PLZF ortholog) acts downstream of ERK and Wnt/β-catenin signaling as a positive transcriptional regulator, functioning redundantly with the Mediator complex component SUR-2 and LIN-25; eor-1 mutants exhibit reduced Ras/Wnt pathway outputs. Genetic epistasis analysis, loss-of-function mutants, double mutant analysis in C. elegans Genes & development High 12130541
2003 PLZF directly represses the CRABPI locus through chromatin condensation propagated from a remote intronic PLZF binding element; the reciprocal fusion RARα-PLZF binds this remote element and recruits p300 to induce promoter hypomethylation and CRABPI upregulation. Chromatin immunoprecipitation, reporter assay, methylation analysis, ChIP Proceedings of the National Academy of Sciences of the United States of America Medium 18000064
2003 PLZF binds directly to a defined PLZF response element (PLZF-RE) in the Hoxb2 r3/r5 enhancer, cooperates with the A/T-rich Krox20 motif for in vivo enhancer activity, and the POZ domain is required for cooperative binding. The APL-associated RARα-PLZF fusion binds the PLZF-RE more strongly than wild-type PLZF. Electrophoretic mobility shift assay, reporter gene assay, in vivo chick neural tube reporter, mutagenesis Oncogene High 12802276
2003 PLZF directly interacts with RAR via its N-terminal zinc finger domain (binding to the RAR ligand-binding domain), independently of ligand. PLZF inhibits RXR-RAR heterodimerization both in vitro and in intact cells, thereby reducing transcriptional activity of RXR-RAR as well as ERα and GR. Yeast two-hybrid, GST pulldown, co-immunoprecipitation, domain mapping, transcriptional reporter assay Nuclear receptor Medium 14521715
2004 Plzf is required intrinsically in adult male germline stem cells for self-renewal; the luxoid mutation introduces a nonsense mutation in Plzf, and transplantation showed the defect is cell-autonomous. Plzf is co-expressed with Oct4 in undifferentiated spermatogonia. Spermatogonial transplantation, positional cloning, immunofluorescence co-localization Nature genetics High 15156142
2005 Gli3 and Plzf cooperate genetically for proximal limb patterning; Gli3−/−;Plzf−/− double-mutant embryos specifically lose proximal (but not distal) cartilage condensations in the hindlimb, correlating with death of Bmpr1b-expressing proximal mesenchymal cells. This cooperation is independent of known P-D patterning markers. Double knockout mouse generation, genetic epistasis, in situ hybridization, histology Nature High 16015334
2007 PLZF directly represses transcription of the Kit gene in spermatogonia; a discrete PLZF binding site in the kit promoter is bound by PLZF in vivo (ChIP) and in vitro; a 3-bp mutation in this site abolishes repression. Plzf−/− undifferentiated spermatogonia show significantly increased kit expression. Chromatin immunoprecipitation, electrophoretic mobility shift assay, promoter-reporter assay, site-directed mutagenesis, qRT-PCR in Plzf−/− cells Molecular and cellular biology High 17664282
2008 PLZF suppresses miR-146a transcription by direct interaction with the miR-146a promoter, and miR-146a in turn targets CXCR4 mRNA to impede its translation, establishing a PLZF→miR-146a→CXCR4 pathway controlling megakaryopoiesis. Rescue experiments confirmed the causal ordering. Reporter gene assay (promoter-luciferase), miRNA overexpression, siRNA knockdown, rescue experiments, flow cytometry Nature cell biology High 18568019
2008 PLZF is sumoylated at K242; sumoylation and ubiquitination at the same site are antagonistic. Oxidative stress (ROS from serum deprivation) inactivates SUMO-conjugating enzymes Uba2/Ubc9, shifts the balance toward ubiquitination, reduces PLZF stability and nuclear localization, decreases BID expression, and induces apoptosis. Site-directed mutagenesis, co-immunoprecipitation, subcellular fractionation, ROS measurement, apoptosis assays Biochemical and biophysical research communications Medium 18348865
2009 PLZF-RARα directly interacts with the PRC1 Polycomb group protein Bmi-1 and forms a stable component of the PRC1 complex, leading to RA-insensitive ectopic recruitment of PRC1 to RA response elements. Bmi-1 is essential for the PLZF-RARα cellular transformation property. Co-immunoprecipitation, chromatin immunoprecipitation, Bmi-1 depletion/functional assay Genes & development High 19451220
2009 PLZF represses c-Kit expression in CD34+ hematopoietic progenitors and during erythropoiesis independently of miR-221/222; PLZF transfection downregulates c-kit, inhibits erythroid proliferation and delays differentiation, while PLZF knockdown has opposite effects. Transfection/overexpression, siRNA knockdown, flow cytometry, qRT-PCR Oncogene Medium 19421145
2009 PLZF restricts proliferation and differentiation of myeloid progenitors. ERK1/2 activation by myeloid cytokines triggers nuclear export and inactivation of PLZF, augmenting mature cell production. Loss of ID2 relieves PLZF-mediated repression of differentiation, identifying ID2 as a functional PLZF target in myelopoiesis. PLZF represses GFI-1, C/EBPα, and LEF-1 transcription factors. PLZF overexpression/knockdown, promoter-binding analysis, cytokine stimulation, ChIP, ID2 rescue experiment Genes & development Medium 19723763
2009 LYRIC/AEG-1 interacts with PLZF (identified by yeast two-hybrid, confirmed in mammalian cells by co-IP); co-expression of LYRIC/AEG-1 with PLZF reduces PLZF binding to target promoters and decreases PLZF-mediated repression. Both proteins co-localize to nuclear bodies containing HDACs. Yeast two-hybrid, co-immunoprecipitation, chromatin immunoprecipitation, immunofluorescence co-localization Oncogene Medium 19648967
2012 Sall4 physically interacts with Plzf in differentiating spermatogonial progenitor cells; Sall4 sequesters Plzf to non-cognate chromatin to derepress Kit expression needed for differentiation, while Plzf displaces Sall4 from cognate chromatin to induce Sall1 expression. Co-immunoprecipitation, chromatin immunoprecipitation, genetic loss-of-function in mice Cell stem cell High 22385656
2012 PLZF controls expression of a limited set of NKT cell functional genes including c-Maf, Id2, ICOS, IL12rb1, and IL18r1; ectopic c-Maf expression complements the IL-4/IL-10 production defect of PLZF-deficient NKT cells, placing c-Maf downstream of PLZF. Microarray gene expression, lentiviral overexpression/rescue, flow cytometry in PLZF KO mice Frontiers in immunology Medium 23267359
2012 Zbtb16 overexpression in brown adipocytes induces thermogenic gene program including fatty acid oxidation, glycolysis, and mitochondrial function genes; increases mitochondrial number, respiratory capacity, and uncoupling; and decreases triglyceride content. Adenoviral overexpression in brown adipocytes, Seahorse respirometry, mitochondrial quantification, gene expression Nutrition & diabetes Medium 23446662
2012 USP37 deubiquitinase interacts with PLZF/RARα through the PLZF moiety and stabilizes PLZF/RARα protein by reducing its poly-ubiquitination. USP37 depletion decreases PLZF/RARα half-life and alleviates PLZF/RARα-mediated target gene suppression and cell transformation. RNAi screen, co-immunoprecipitation, domain mapping, ubiquitination assay, pulse-chase protein stability, transformation assay Oncogene Medium 23208507
2013 PLZF represses L1 retrotransposons by inducing DNA methylation at full-length L1 sequences, inhibiting L1 retrotransposition. PLZF also creates barrier-type boundaries at truncated L1 insertions in protein-coding genes. Cell stress releases PLZF-mediated repression, resulting in L1 activation and impaired spermatogenesis/myelopoiesis. Chromatin immunoprecipitation, bisulfite sequencing, retrotransposition assay, stress-induction experiments The EMBO journal Medium 23727884
2013 PLZF is a downstream mediator of the PTEN/AKT pathway; FOXO3a (a transcription factor phosphorylated by PI3K/AKT) directly binds the PLZF promoter as shown by ChIP and luciferase reporter assay. PTEN restoration or PI3K inhibition increases PLZF expression. Chromatin immunoprecipitation, luciferase reporter assay, pharmacological PI3K inhibition, PTEN rescue PloS one Medium 24339862
2013 RARα-PLZF interacts with C/EBPα tethered to DNA and recruits HDAC1, causing histone H3 deacetylation at C/EBPα target loci and inhibiting C/EBPα-dependent myeloid differentiation. HDAC inhibitors partially restore C/EBPα target gene expression. ChIP, DNA capture assay, HDAC inhibitor treatment, gene expression analysis Proceedings of the National Academy of Sciences of the United States of America Medium 23898169
2013 Znf179 interacts with Plzf (identified by yeast two-hybrid, confirmed by co-IP); this interaction requires the first two zinc fingers of Plzf. Co-expression of Plzf causes nuclear translocation of Znf179 (from cytoplasm) and increases Plzf protein abundance. Yeast two-hybrid, co-immunoprecipitation, domain mapping, immunofluorescence Journal of biomedical science Low 24359566
2013 PLZF promotes Eya2 expression; PLZF-RARA as well as PLZF alone immortalizes hematopoietic stem/progenitor cells through Eya2 upregulation. Eya2 depletion suppresses clonogenicity in PLZF-RARA-immortalized cells. PLZF immortalization requires the BTB/POZ domain. Expression profiling, retroviral transduction, shRNA knockdown, colony formation assay, BTB domain deletion mutant Molecular and cellular biology Medium 28416638
2013 PLZF directly represses Kit, Stra8, Sohlh2, and Dmrt1 promoters in spermatogonial progenitor cells as shown by ChIP-qPCR and dual luciferase assay; knockdown of PLZF upregulates all four genes. Chromatin immunoprecipitation-qPCR, dual luciferase reporter assay, siRNA knockdown Journal of cellular physiology Medium 31541472
2013 PLZF loss-of-function leads to hematopoietic stem cell (HSC) lineage skewing from lymphopoiesis toward myelopoiesis, increased long-term HSC pool size, decreased repopulation potential, and a G1-S transition defect in cell cycle progression. These effects are associated with a transcriptional signature of stemness loss. Zbtb16lu/lu mouse model, transplantation assay, cell cycle analysis, transcriptomic profiling Blood High 26941402
2015 ZBTB16 acts as the substrate receptor of a ZBTB16-Cullin3-Roc1 E3 ubiquitin ligase complex that ubiquitinates and targets Atg14L for proteasomal degradation. GPCR agonists suppress autophagy by activating this pathway to reduce Atg14L levels. Co-immunoprecipitation, ubiquitination assay, proteasome inhibitor treatment, GPCR agonist treatment, in vitro degradation assay eLife High 25821988
2015 Let-7 miRNAs directly target Zbtb16 mRNA to post-transcriptionally repress PLZF expression during NKT thymocyte development; upregulation of let-7 by IL-15, vitamin D, and retinoic acid drives NKT1 differentiation, while maintained high PLZF drives NKT2/NKT17 fates. Reporter assay for miRNA targeting, genetic let-7 deletion/overexpression, cytokine stimulation, flow cytometry Nature immunology High 25848867
2015 Signaling from TLR or TNF-α receptors activates CaMK2, which activates HAT1; HAT1 then directly acetylates PLZF, promoting assembly of a repressor complex containing HDAC3 and NF-κB p50, which limits NF-κB transcriptional responses and inflammatory cytokine production. Co-immunoprecipitation, kinase assay, acetylation assay, site-directed mutagenesis of key PLZF/HAT1 residues, siRNA knockdown, cytokine measurement Nature communications High 25865065
2015 PLZF binds enhancer-like sites ~9-10 and ~13-14 kb upstream of the CCR6 transcription start site in human Th17 cells; PLZF knockdown downregulates CCR6 and other Th17-associated genes; PLZF and RORC cross-regulate each other and PLZF binds the RORC promoter. ChIP for histone marks and PLZF, siRNA knockdown, gene expression analysis Journal of immunology Medium 25833398
2016 PLZF binds and directly regulates genes encoding cytokine receptors, homing/adhesion receptors, and T-helper-specific transcription factor genes in NKT cells; PLZF binds and suppresses Bach2 transcription. ChIP-seq and microarray analysis defined the multilayered transcriptional architecture. Biotinylation-based ChIP-seq, microarray gene expression, PLZF-transgenic thymocytes Proceedings of the National Academy of Sciences of the United States of America High 27325774
2016 PLZF genome-wide binding in THY1+ spermatogonia (ChIP-seq) identified 4176 PLZF-bound genes preferentially at promoters; PLZF and SALL4 share 1295 targets, with PLZF motifs predominant at shared sites. PLZF and SALL4 knockdown suppresses both self-renewal and differentiation gene targets. ChIP-seq, motif analysis, siRNA knockdown, RNA-seq Development High 27068105
2017 A Runx1-bound enhancer within the Zbtb16 locus is the critical cis-regulatory element controlling PLZF expression in innate and innate-like lymphoid lineages; CRISPR/Cas9 deletion of this enhancer abolishes PLZF expression in these lineages. Runx1 binding sites within the enhancer are required. CRISPR/Cas9 enhancer deletion in mice, ATAC-seq, ChIP-seq for Runx1 Nature communications High 29038474
2018 PLZF is co-recruited with EZH2 at PLZF target gene loci independently of PRC2/SUZ12 and H3K27me3; this EZH2-PLZF co-occupancy correlates with H3K4me3 and active transcription. Removal of EZH2 increases PLZF binding and increases expression of PLZF target genes, suggesting non-canonical EZH2 activity restrains PLZF's activating function. ChIP-seq for PLZF, EZH2, SUZ12, H3K27me3, H3K4me3; EZH2 depletion; gene expression analysis Nucleic acids research Medium 29425303
2018 Bcl11b directly represses Zbtb16 (PLZF) in pro-T cells; deletion of Bcl11b derepresses PLZF, which then activates an alternative developmental program. Proteomics showed Bcl11b associates with cofactors recruited to Zbtb16 locus; Runx1 collaborates with Bcl11b for repression. In vivo stage-specific deletion, ChIP-seq, proteomics, gene expression profiling Nature immunology High 30374131
2019 PLZF is recruited to osteogenic enhancers during hMSC osteogenic differentiation, influencing H3K27 acetylation and expression of nearby osteogenic genes. The ZBTB16 locus is repressed by Polycomb/H3K27me3 in naive hMSCs; upon differentiation, JMJD3 is recruited and H3K27ac is gained. A PLZF-bound latent enhancer within the ZBTB16 locus loops to the NNMT promoter, increasing NNMT expression and reducing SAM levels required for osteogenesis. ChIP-seq, H3K27me3/H3K27ac profiling, PLZF knockdown, chromosome conformation capture, NNMT expression analysis eLife High 30672466
2019 PLZF regulates the proliferative activity of EOMES+ spermatogonial stem cells; in Plzf-null mice, EOMES+ SSCs exhibit higher proliferation index, leading to their exhaustion. Single-cell RNA-seq supports SSC hierarchical yet heterogeneous organization. GDNF transgenic model, lineage tracing, busulfan challenge, BrdU proliferation, scRNA-seq eLife Medium 31149899
2020 ZBTB16 is a CRBN (cereblon) neosubstrate; cereblon modulators CC-3060 and CC-647 engage distinct zinc finger domains of ZBTB16 (first/third ZF) as structural degrons to promote its proteasomal degradation. The same degrons are present in ZBTB16-RARα and RARα-ZBTB16 fusion oncoproteins. Protein degradation assay, domain mapping with cereblon modulator compounds, biochemical binding assays ACS chemical biology High 33206504
2021 PLZF/ZBTB16 is degraded by the CRL4CRBN E3 ubiquitin ligase in complex with thalidomide or 5-hydroxythalidomide; this degradation is dependent on the first and third zinc finger domains of PLZF. PLZF knockdown in chicken embryos causes short bone formation, and PLZF overexpression partially rescues thalidomide-induced teratogenic phenotypes. Human transcription factor array in wheat cell-free system, proteasome inhibitor treatment, domain deletion analysis, in ovo knockdown/overexpression, IHC in chicken embryos The EMBO journal High 33470442
2013 8-CPT-cAMP combined with ATRA causes PKA-mediated phosphorylation of PLZF/RARα at Ser765, increasing dissociation of SMRT/NCoR corepressor from PLZF/RARα, reactivating RA target gene transcription, and promoting PLZF/RARα degradation. Phosphorylation assay, co-immunoprecipitation of corepressor, chromatin analysis, PLZF/RARα protein stability, in vivo mouse APL model Proceedings of the National Academy of Sciences of the United States of America High 23382200
2023 Nuclear ZBTB16 promotes SUMOylation of the inflammasome adaptor ASC, which controls inflammasome assembly. Ablation of ZBTB16 in mice reduces acute inflammatory pathogenesis in a Muckle-Wells syndrome model of constitutively active inflammasome. SUMOylation assay, co-immunoprecipitation, ZBTB16 knockout in Muckle-Wells mouse model, inflammasome activation assays Nature communications High 38123560
2024 Glucocorticoids increase ZBTB16 expression in human cerebral organoids and mouse cortical progenitors, which in turn increases basal progenitors co-expressing PAX6 and EOMES, leading to increased neuron production. ZBTB16 mediates the effect of glucocorticoids on cortical neurogenesis. Human cerebral organoids, mouse model, siRNA/CRISPR knockdown of ZBTB16, cell-type-specific quantification, Mendelian randomization Neuron Medium 38442714

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Plzf is required in adult male germ cells for stem cell self-renewal. Nature genetics 719 15156142
1998 Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL. Nature genetics 488 9462740
1997 SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America 308 9256429
1998 Crystal structure of the BTB domain from PLZF. Proceedings of the National Academy of Sciences of the United States of America 256 9770450
2000 Plzf regulates limb and axial skeletal patterning. Nature genetics 246 10835630
2008 A three-step pathway comprising PLZF/miR-146a/CXCR4 controls megakaryopoiesis. Nature cell biology 192 18568019
2007 Repression of kit expression by Plzf in germ cells. Molecular and cellular biology 159 17664282
1999 Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A. Oncogene 159 10023668
2012 Functional antagonism between Sall4 and Plzf defines germline progenitors. Cell stem cell 143 22385656
1998 Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6. The Journal of biological chemistry 140 9765306
2015 PLZF expression maps the early stages of ILC1 lineage development. Proceedings of the National Academy of Sciences of the United States of America 135 25838284
2015 Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function. Nature immunology 122 25848867
2009 The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation. Genes & development 109 19451220
1999 A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. Blood 108 10572087
1995 Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain. Proceedings of the National Academy of Sciences of the United States of America 104 7892256
2018 Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16. Nature immunology 97 30374131
2015 G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L. eLife 87 25821988
2016 Multiple layers of transcriptional regulation by PLZF in NKT-cell development. Proceedings of the National Academy of Sciences of the United States of America 84 27325774
2009 PLZF is a regulator of homeostatic and cytokine-induced myeloid development. Genes & development 84 19723763
2016 The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia. Development (Cambridge, England) 83 27068105
2005 Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development. Nature 83 16015334
2011 Evaluation of Sycp3, Plzf and Cyclin B3 expression and suitability as spermatogonia and spermatocyte markers in zebrafish. Gene expression patterns : GEP 81 21402175
2011 Development of PLZF-expressing innate T cells. Current opinion in immunology 79 21257299
2016 Concise Review: Balancing Stem Cell Self-Renewal and Differentiation with PLZF. Stem cells (Dayton, Ohio) 78 26676652
1996 Reduced and altered DNA-binding and transcriptional properties of the PLZF-retinoic acid receptor-alpha chimera generated in t(11;17)-associated acute promyelocytic leukemia. Oncogene 76 8570209
2002 C. elegans EOR-1/PLZF and EOR-2 positively regulate Ras and Wnt signaling and function redundantly with LIN-25 and the SUR-2 Mediator component. Genes & development 73 12130541
2015 The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF. Nature communications 71 25865065
2021 Thalidomide and its metabolite 5-hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF. The EMBO journal 70 33470442
2015 PLZF Controls the Development of Fetal-Derived IL-17+Vγ6+ γδ T Cells. Journal of immunology (Baltimore, Md. : 1950) 64 26408661
2019 Identification of EOMES-expressing spermatogonial stem cells and their regulation by PLZF. eLife 61 31149899
2009 Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression. Oncogene 60 19648967
2003 Promyelocytic leukaemia zinc finger protein (PLZF) is a glucocorticoid- and progesterone-induced transcription factor in human endometrial stromal cells and myometrial smooth muscle cells. Molecular human reproduction 58 12970399
2004 Role of PLZF in melanoma progression. Oncogene 57 15077196
2017 A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development. Nature communications 55 29038474
2012 Zbtb16 has a role in brown adipocyte bioenergetics. Nutrition & diabetes 55 23446662
2007 RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America 55 18000064
1999 The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase. Nucleic acids research 54 10497277
2021 Zbtb16 regulates social cognitive behaviors and neocortical development. Translational psychiatry 47 33895774
2009 The promyelocytic leukemia zinc-finger gene, PLZF, is frequently downregulated in malignant mesothelioma cells and contributes to cell survival. Oncogene 47 20010871
2002 PLZF induces megakaryocytic development, activates Tpo receptor expression and interacts with GATA1 protein. Oncogene 46 12242665
2018 ZBTB16 Overexpression Enhances White Adipogenesis and Induces Brown-Like Adipocyte Formation of Bovine White Intramuscular Preadipocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 44 30121655
2012 PLZF Controls the Expression of a Limited Number of Genes Essential for NKT Cell Function. Frontiers in immunology 44 23267359
2020 BTB/POZ zinc finger protein ZBTB16 inhibits breast cancer proliferation and metastasis through upregulating ZBTB28 and antagonizing BCL6/ZBTB27. Clinical epigenetics 43 32517789
2024 Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis. Cell death and differentiation 42 38287116
2019 PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells. eLife 42 30672466
2004 Identification and characterization of PLZF as a prostatic androgen-responsive gene. The Prostate 41 15065091
1996 PML, PLZF and NPM genes in the molecular pathogenesis of acute promyelocytic leukemia. Haematologica 41 8952164
2015 Zbtb16 (PLZF) is stably suppressed and not inducible in non-innate T cells via T cell receptor-mediated signaling. Scientific reports 39 26178856
2003 Regulation of Hoxb2 by APL-associated PLZF protein. Oncogene 39 12802276
2018 PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2. Cell death & disease 38 29358655
2017 Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat. Hypertension (Dallas, Tex. : 1979) 38 28396530
2012 The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability. Oncogene 38 23208507
2013 PLZF mediates the PTEN/AKT/FOXO3a signaling in suppression of prostate tumorigenesis. PloS one 37 24339862
2015 PLZF regulates CCR6 and is critical for the acquisition and maintenance of the Th17 phenotype in human cells. Journal of immunology (Baltimore, Md. : 1950) 36 25833398
2013 PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors. PLoS biology 36 24115909
2017 ZBTB16 and metabolic syndrome: a network perspective. Physiological research 35 28948820
2020 Cereblon Modulators Target ZBTB16 and Its Oncogenic Fusion Partners for Degradation via Distinct Structural Degrons. ACS chemical biology 34 33206504
2016 ZBTB16 as a Downstream Target Gene of Osterix Regulates Osteoblastogenesis of Human Multipotent Mesenchymal Stromal Cells. Journal of cellular biochemistry 34 27335174
2013 ZBTB16 induces osteogenic differentiation marker genes in dental follicle cells independent from RUNX2. Journal of periodontology 34 24359167
2010 PLZF/ZBTB16, a glucocorticoid response gene in acute lymphoblastic leukemia, interferes with glucocorticoid-induced apoptosis. The Journal of steroid biochemistry and molecular biology 34 20435142
2007 Identification of apoptosis-related PLZF target genes. Biochemical and biophysical research communications 34 17537403
2018 Human endometrial stromal cell decidualization requires transcriptional reprogramming by PLZF. Biology of reproduction 33 29186366
2017 Role of PLZF as a tumor suppressor in prostate cancer. Oncotarget 33 29050363
2003 PLZF is a negative regulator of retinoic acid receptor transcriptional activity. Nuclear receptor 32 14521715
2019 Androgen promotes differentiation of PLZF+ spermatogonia pool via indirect regulatory pattern. Cell communication and signaling : CCS 31 31142324
2015 Loss of PLZF expression in prostate cancer by immunohistochemistry correlates with tumor aggressiveness and metastasis. PloS one 31 25807461
2013 The epigenetic regulator PLZF represses L1 retrotransposition in germ and progenitor cells. The EMBO journal 31 23727884
2002 Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein. Blood 31 11964310
2013 Hypermethylation reduces expression of tumor-suppressor PLZF and regulates proliferation and apoptosis in non-small-cell lung cancers. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 29 23804241
2013 RARα-PLZF oncogene inhibits C/EBPα function in myeloid cells. Proceedings of the National Academy of Sciences of the United States of America 29 23898169
2008 PLZF and the (pro)renin receptor. Journal of molecular medicine (Berlin, Germany) 28 18335187
2023 Inflammasome activity is controlled by ZBTB16-dependent SUMOylation of ASC. Nature communications 27 38123560
2024 Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression. Neuron 26 38442714
2019 PLZF suppresses differentiation of mouse spermatogonial progenitor cells via binding of differentiation associated genes. Journal of cellular physiology 26 31541472
2018 Regulation of the positive transcriptional effect of PLZF through a non-canonical EZH2 activity. Nucleic acids research 26 29425303
2014 Dexamethasone-related osteogenic differentiation of dental follicle cells depends on ZBTB16 but not Runx2. Cell and tissue research 26 24816988
2013 Plzf as a candidate gene predisposing the spontaneously hypertensive rat to hypertension, left ventricular hypertrophy, and interstitial fibrosis. American journal of hypertension 26 23975223
1999 Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP. Biochemical and biophysical research communications 26 10544010
2016 PLZF mutation alters mouse hematopoietic stem cell function and cell cycle progression. Blood 25 26941402
2009 PLZF-mediated control on c-kit expression in CD34(+) cells and early erythropoiesis. Oncogene 25 19421145
2019 Distinct PLZF+CD8αα+ Unconventional T Cells Enriched in Liver Use a Cytotoxic Mechanism to Limit Autoimmunity. Journal of immunology (Baltimore, Md. : 1950) 24 31554695
2016 ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 24 26916077
2013 Plzf drives MLL-fusion-mediated leukemogenesis specifically in long-term hematopoietic stem cells. Blood 24 23838347
2013 Analysis of the interaction between Zinc finger protein 179 (Znf179) and promyelocytic leukemia zinc finger (Plzf). Journal of biomedical science 24 24359566
2007 The PLZF gene of t (11;17)-associated APL. Current topics in microbiology and immunology 24 17217037
2023 Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis. Bone research 23 37280207
2020 PLZF-RARα, NPM1-RARα, and Other Acute Promyelocytic Leukemia Variants: The PETHEMA Registry Experience and Systematic Literature Review. Cancers 23 32455804
2011 Characterisation of genome-wide PLZF/RARA target genes. PloS one 21 21949697
2019 Expression of the PTEN/FOXO3a/PLZF signalling pathway in pancreatic cancer and its significance in tumourigenesis and progression. Investigational new drugs 20 31087222
2019 The REGγ-Proteasome Regulates Spermatogenesis Partially by P53-PLZF Signaling. Stem cell reports 20 31402338
2011 The promyelocytic leukemia zinc finger (PLZF) protein exerts neuroprotective effects in neuronal cells and is dysregulated in experimental stroke. Brain pathology (Zurich, Switzerland) 20 20731660
2009 Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down-regulation in limb bud and polydactyly in the rat. Developmental dynamics : an official publication of the American Association of Anatomists 20 19191224
2021 Optineurin deletion disrupts metabotropic glutamate receptor 5-mediated regulation of ERK1/2, GSK3β/ZBTB16, mTOR/ULK1 signaling in autophagy. Biochemical pharmacology 19 33513340
2019 Acute promyelocytic leukemia and variant fusion proteins: PLZF-RARα fusion protein at a glance. Seminars in oncology 19 31126665
2014 Innate PLZF+CD4+ αβ T cells develop and expand in the absence of Itk. Journal of immunology (Baltimore, Md. : 1950) 19 24928994
2013 8-CPT-cAMP/all-trans retinoic acid targets t(11;17) acute promyelocytic leukemia through enhanced cell differentiation and PLZF/RARα degradation. Proceedings of the National Academy of Sciences of the United States of America 19 23382200
2008 Redox-mediated modification of PLZF by SUMO-1 and ubiquitin. Biochemical and biophysical research communications 19 18348865
2001 Acute promyelocytic leukemia with a PLZF-RARalpha fusion protein. Seminars in hematology 19 11172538
2017 Eya2, a Target Activated by Plzf, Is Critical for PLZF-RARA-Induced Leukemogenesis. Molecular and cellular biology 18 28416638
2017 ZBTB16 gene variability influences obesity-related parameters and serum lipid levels in Czech adults. Physiological research 18 28948827

Missed literature

Know a paper Affinage missed for ZBTB16? Flag it for the maintainers and the community.

No submissions yet.