Affinage

WTAP

Pre-mRNA-splicing regulator WTAP · UniProt Q15007

Length
396 aa
Mass
44.2 kDa
Annotated
2026-06-11
100 papers in source corpus 40 papers cited in narrative 40 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

WTAP is an essential, non-catalytic regulatory subunit of the nuclear m6A methyltransferase complex, where it interacts with METTL3 and METTL14, drives their localization to nuclear speckles, and is required for catalytic m6A deposition in vivo by enabling complex recruitment to mRNA targets (PMID:24407421). The complex is built through ordered assembly in which a cleaved form of METTL3 (METTL3a) mediates METTL3-METTL3 interaction as a prerequisite for WTAP recruitment, while METTL14 provides RNA-substrate binding through its C-terminal RGG repeats (PMID:29348140, PMID:37589705). WTAP and METTL3 are mutually dependent for protein homeostasis, and in several tissues WTAP loss destabilizes METTL3/14 such that Mettl3 re-expression rescues the phenotype, establishing WTAP as an upstream stabilizer of the writer machinery (PMID:30038300, PMID:39872074, PMID:36920524). Through m6A deposition read out by YTHDF1/2, YTHDC1, and IGF2BPs, WTAP controls the stability, translation, splicing, and miRNA processing of defined transcripts to govern embryonic differentiation, adipogenesis, spermatogenesis, T-cell and innate immune signaling, and neuronal and cardiac homeostasis (PMID:29866655, PMID:18224709, PMID:35879451, PMID:33053361, PMID:35304325, PMID:39007267). WTAP itself is a regulatory hub: its protein stability and nuclear localization are tuned by ERK1/2- and CDK9-mediated phosphorylation, OGT O-GlcNAcylation, USP7 de-ubiquitination, and proteasomal degradation, and its abundance is set transcriptionally by HIF1α, NF-κB p65, p300, and chromatin modifiers (PMID:34312368, PMID:35927268, PMID:35781818, PMID:39007267, PMID:39671515). Beyond its canonical m6A role, WTAP also acts m6A-independently in some contexts by binding chromatin directly—activating Mef2c promoter activity in cardiomyocytes and associating with RNA polymerase II to maintain proteasome-gene expression in hepatocytes (PMID:38224851, PMID:35927268, PMID:37777158).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 2008 High

    Established WTAP as a developmentally essential gene before its molecular function was known, defining the biological stakes of its later-characterized activity.

    Evidence Gene-trap knockout and chimera analysis in mouse embryos and ES cells

    PMID:18224709

    Open questions at the time
    • Molecular mechanism of the differentiation block not defined at this stage
    • No link to m6A yet established
  2. 2014 High

    Defined WTAP's core molecular function: a regulatory subunit that recruits METTL3/METTL14 to mRNA and is required for nuclear-speckle localization and catalytic m6A activity, explaining its essentiality.

    Evidence Co-IP, PAR-CLIP, speckle localization, knockdown, transcriptomics, zebrafish morpholino

    PMID:24407421

    Open questions at the time
    • Does not resolve assembly order of the complex
    • Direct mRNA-recruitment mechanism inferred from reduced METTL3 RNA binding, not structurally defined
  3. 2018 High

    Resolved the architecture and catalytic logic of the writer complex, showing METTL3 is the active subunit, METTL14 is catalytically degenerate but contributes RNA binding via RGG repeats, and mapping WTAP binding surfaces and phosphosites.

    Evidence Recombinant binding-surface mapping, in vitro methylation, RGG mutagenesis, phosphosite identification

    PMID:29348140

    Open questions at the time
    • Functional consequence of mapped WTAP phosphosites not tested
    • WTAP's precise structural contribution to activity not resolved
  4. 2018 High

    Showed WTAP and METTL3 are mutually dependent for protein homeostasis and that WTAP's oncogenic activity strictly requires a functional methylation complex, and that the complex drives adipogenesis via cell-cycle control in clonal expansion.

    Evidence METTL3 KD/OE with western blot and proliferation assays; siRNA KD, Wtap heterozygous KO mice, diet-induced obesity model

    PMID:29866655 PMID:30038300

    Open questions at the time
    • Mechanism by which METTL3 sets WTAP protein levels not defined in 2018
    • Direct cell-cycle target transcripts not fully enumerated
  5. 2020 High

    Demonstrated tissue-specific requirement for WTAP-dependent m6A in regulating both alternative splicing and translation of niche-factor transcripts during spermatogenesis.

    Evidence Conditional Sertoli-cell Wtap KO, m6A-seq, RNA-seq, ribosome-bound mRNA sequencing

    PMID:33053361

    Open questions at the time
    • Individual causal target transcripts not isolated
    • Reader proteins mediating splicing vs translation effects not assigned
  6. 2021 High

    Defined direct mRNA targets in T cells, showing m6A destabilization of Orai1 and Ripk1 couples WTAP to calcium signaling and T-cell survival, extending its role to adaptive immunity.

    Evidence Conditional Wtap KO in T cells, MeRIP-seq, calcium-entry assays, T-cell phenotyping

    PMID:35879451

    Open questions at the time
    • Reader protein for Orai1/Ripk1 destabilization not specified
    • Direct vs indirect contribution to Treg function not fully separated
  7. 2021 Medium

    Began mapping upstream control of WTAP, showing ERK1/2 phosphorylation at S341 stabilizes the protein in response to inflammatory cytokines, linking the tumor microenvironment to m6A output.

    Evidence ERK inhibition, phosphosite identification, WTAP stability western blot, ENO1 MeRIP, glycolysis and in vivo assays

    PMID:34312368

    Open questions at the time
    • S341 not validated by phospho-dead mutagenesis in the report
    • Single lab/cancer context
  8. 2022 High

    Established that WTAP loss destabilizes METTL3/14 protein across multiple tissues, with Mettl3 re-expression rescuing phenotypes, defining WTAP as an upstream stabilizer of the writer complex in brown fat, beta cells, and Purkinje neurons.

    Evidence Tissue-specific Wtap KOs, METTL3/14 western blots, Mettl3 overexpression rescue, MeRIP-seq, snRNA-seq

    PMID:35304325 PMID:36920524 PMID:39872074

    Open questions at the time
    • Molecular basis of METTL3/14 destabilization upon WTAP loss not resolved
    • Why rescue is only partial not explained
  9. 2022 High

    Uncovered m6A-independent chromatin functions of WTAP: direct promoter binding to activate Mef2c in cardiomyocytes (METTL3-non-rescuable) and DNA-motif binding with HDAC1 to repress lipid/inflammatory genes in hepatocytes, where CDK9 phosphorylation drives nuclear-to-cytoplasmic translocation.

    Evidence Cardiomyocyte- and hepatocyte-specific Wtap KO, failed Mettl3 rescue, ATAC-seq, ChIP, luciferase, CDK9 kinase assay, subcellular fractionation

    PMID:35927268 PMID:38224851

    Open questions at the time
    • DNA sequence specificity and structural basis of WTAP chromatin binding undefined
    • Determinants choosing m6A vs chromatin mode per tissue unknown
  10. 2022 High

    Showed WTAP relocalizes to the cytoplasm during HCV infection to m6A-modify viral RNA and restrict infectious virion production, demonstrating localization-dependent functional switching independent of nuclear residence.

    Evidence Subcellular fractionation, RIP with HCV RNA, viral m6A-seq, NLS-mutant rescue, virion production assays

    PMID:36314819

    Open questions at the time
    • Trigger and machinery for WTAP cytoplasmic relocalization not defined
    • Whether cytoplasmic complex is identical to nuclear MTC unknown
  11. 2022 Medium

    Expanded WTAP's regulatory repertoire to non-canonical RNA processing, showing it partners with the microprocessor component DGCR8 to accelerate m6A-dependent pri-miRNA maturation (miR-181, miR-29b, miR-200, miR-92b) read out by YTHDC1.

    Evidence Co-IP (WTAP-DGCR8), MeRIP, RIP, luciferase, differentiation/glycolysis assays, in vivo models

    PMID:35733918 PMID:36650131 PMID:37010483 PMID:37563688

    Open questions at the time
    • Direct vs indirect WTAP-DGCR8 association not reconstituted
    • Each axis from a single lab/disease context
  12. 2022 Medium

    Identified circRNA-mediated regulation of complex assembly, with circ0008399 promoting and circPDE5A blocking WTAP-dependent m6A on specific target mRNAs, adding a layer of post-transcriptional control over WTAP activity.

    Evidence RNA pulldown, RIP, MeRIP, Co-IP for complex assembly, functional drug-sensitivity/metastasis assays

    PMID:34702726 PMID:35650605

    Open questions at the time
    • Binding stoichiometry and structural mode of circRNA-WTAP interaction unknown
    • Single-lab cancer-specific contexts
  13. 2023 High

    Defined a second m6A-independent chromatin function: WTAP associates with RNA polymerase II and H3K9ac to maintain proteasome-gene expression, with loss stabilizing GRB2/ERK1/2 to drive hepatocyte proliferation, rescued by PSMB4/PSMB6 restoration.

    Evidence Hepatocyte-specific Wtap KO, ChIP for Pol II and H3K9ac, GRB2/ERK westerns, genetic rescue

    PMID:37777158

    Open questions at the time
    • Mechanism of WTAP-Pol II recruitment to specific promoters unknown
    • How chromatin vs m6A activity is partitioned in hepatocytes unresolved
  14. 2023 High

    Established multilayered transcriptional and post-translational control of WTAP abundance and assembly: HIF1α transactivation, PRMT1 methylation of WTAP, and proteasome/mTOR-dependent METTL3 cleavage that licenses WTAP recruitment.

    Evidence HIF1α ChIP, PRMT1 Co-IP/methylation/MeRIP, METTL3a MS identification, Co-IP, mTOR/proteasome inhibition, mutagenesis

    PMID:37087529 PMID:37558663 PMID:37589705

    Open questions at the time
    • WTAP arginine methylation site and stoichiometry not mapped
    • Integration of these inputs under physiological conditions untested
  15. 2023 High

    Linked WTAP abundance to liquid-liquid phase separation, showing NF-κB p65-driven WTAP elevation promotes phase-separated aggregation of the writer complex at nuclear speckles to mark inflammatory transcripts, with myeloid WTAP loss protecting against sepsis and colitis.

    Evidence Myeloid-specific Wtap KO, p65 ChIP, phase separation assay, m6A-seq, LPS and DSS models

    PMID:39007267

    Open questions at the time
    • Domains and determinants of WTAP phase separation not mapped
    • Quantitative link between condensate formation and catalytic output not established
  16. 2025 Medium

    Integrated combinatorial PTM control, showing OGT O-GlcNAcylation and USP7 de-ubiquitination synergistically stabilize WTAP in glioblastoma to drive an IGF2BP2-dependent LOXL2 m6A program promoting immune evasion.

    Evidence MS for O-GlcNAc sites, Co-IP (WTAP-USP7, WTAP-OGT), IGF2BP2 RIP, MeRIP, integrin signaling, scRNA-seq

    PMID:39671515

    Open questions at the time
    • Crosstalk hierarchy between O-GlcNAcylation, ubiquitination, and phosphorylation unresolved
    • Single tumor context

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a single regulatory subunit switches between recruiting the m6A writer complex and acting directly on chromatin, and what tissue- and signal-specific cues select among its phosphorylation, methylation, O-GlcNAcylation, ubiquitination, and phase-separation states, remains unresolved.
  • No unified structural model linking PTM state to nuclear/cytoplasmic/chromatin localization
  • Determinants of m6A-dependent vs m6A-independent mode not defined
  • Direct vs indirect nature of many reported target interactions not reconstituted in vitro

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140098 catalytic activity, acting on RNA 5 GO:0003723 RNA binding 3 GO:0098772 molecular function regulator activity 3 GO:0140110 transcription regulator activity 3 GO:0003677 DNA binding 2 GO:0060090 molecular adaptor activity 2
Localization
GO:0005634 nucleus 3 GO:0000228 nuclear chromosome 2 GO:0005654 nucleoplasm 2 GO:0005829 cytosol 2
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-392499 Metabolism of proteins 4 R-HSA-1430728 Metabolism 3 R-HSA-168256 Immune System 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-8953854 Metabolism of RNA 3
Partners
DGCR8HDAC1METTL14METTL3OGTPRMT1RNA POLYMERASE IIUSP7
Complex memberships
m6A methyltransferase complex (METTL3-METTL14-WTAP)

Evidence

Reading pass · 40 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2014 WTAP is a regulatory subunit of the m6A methyltransferase complex: it interacts with METTL3 and METTL14, is required for their localization into nuclear speckles, and is required for catalytic m6A methyltransferase activity in vivo. In the absence of WTAP, the RNA-binding capability of METTL3 is strongly reduced, indicating WTAP regulates recruitment of the complex to mRNA targets. Co-immunoprecipitation, PAR-CLIP, nuclear speckle localization experiments, knockdown studies, transcriptomic analyses, zebrafish morpholino knockdown Cell research High 24407421
2018 Recombinant protein mapping defined binding surfaces within the METTL3/METTL14-WTAP complex; nuclear localization signals were identified on each subunit; phosphorylation sites were identified on the endogenous proteins. Monomeric METTL3 is soluble but inactive, and the catalytic center of METTL14 is degenerate and inactive; the C-terminal RGG repeats of METTL14 contribute to RNA substrate binding and are required for METTL3/14 activity. Recombinant protein binding surface mapping, in vitro methylation assay, mutagenesis of RGG repeats, phosphorylation site identification on endogenous proteins RNA (New York, N.Y.) High 29348140
2018 Both knockdown and overexpression of METTL3 results in upregulation of WTAP protein, demonstrating that METTL3 levels are critical for WTAP protein homeostasis. WTAP upregulation alone is not sufficient to promote cell proliferation in the absence of functional METTL3, indicating WTAP's oncogenic function is strictly dependent on a functional m6A methylation complex. METTL3 knockdown and overexpression, western blot, cell proliferation assays Cell death & disease Medium 30038300
2018 The WTAP-METTL3-METTL14 RNA N6-adenosine methyltransferase complex positively controls adipogenesis by promoting cell cycle transition during mitotic clonal expansion (MCE). Knockdown of WTAP (or METTL3/METTL14) leads to cell cycle arrest and impaired adipogenesis associated with suppression of cyclin A2 upregulation. Wtap heterozygous knockout mice are protected from diet-induced obesity with smaller, fewer adipocytes and improved insulin sensitivity. siRNA knockdown of WTAP/METTL3/METTL14, cell cycle analysis, adipogenesis assays, Wtap heterozygous knockout mouse model, diet-induced obesity model Molecular and cellular biology High 29866655
2008 Wtap is essential for differentiation of endoderm and mesoderm during mouse embryogenesis. Wtap gene-trap mutant embryos fail to form endoderm and mesoderm, die by E10.5, and Wtap mutant embryonic stem cells fail to differentiate into these lineages. Chimera analysis showed Wtap function in extraembryonic tissues is required for mesoderm/endoderm formation in embryonic tissues. Gene-trap mouse knockout, chimera analysis, embryonic stem cell differentiation assays Developmental dynamics High 18224709
2021 WTAP regulates TCR signaling, thymocyte differentiation, activation-induced death of peripheral T cells, and gut RORγt+ regulatory T cell function. Transcriptome and epitranscriptomic analyses showed that m6A modification destabilizes Orai1 and Ripk1 mRNAs; loss of this post-transcriptional repression correlates with increased store-operated calcium entry and diminished T cell survival in Wtap conditional knockout mice. Conditional genetic inactivation of Wtap in T cells, transcriptome/MeRIP-seq analyses, calcium entry assays, T cell phenotyping Nature immunology High 35879451
2020 Conditional deletion of Wtap in Sertoli cells results in sterility and progressive loss of spermatogonial stem cell (SSC) population. m6A sequencing identified 21,909 m6A sites across 6,122 genes in Sertoli cells. Wtap deletion sharply alters alternative splicing of transcripts encoding SSC niche factors and severely dysregulates their translation. Conditional Wtap knockout in Sertoli cells, m6A sequencing, RNA sequencing, ribosome nascent-chain complex-bound mRNA sequencing Stem cell reports High 33053361
2022 WTAP is required for postnatal development and maturation of brown adipose tissue (BAT). BAT-specific knockout of Wtap impairs maturation and causes whitening of interscapular BAT, hypothermia, and cold intolerance. Mechanistically, WTAP deficiency decreases m6A mRNA modification by reducing the protein stability of METTL3; BAT-specific overexpression of Mettl3 partially rescues the phenotypes. BAT-specific Wtap knockout, phenotypic analysis (cold challenge, thermogenesis), western blot for METTL3 protein stability, Mettl3 overexpression rescue, single nucleus RNA-seq Life metabolism High 39872074
2022 WTAP is required for maintaining islet beta cell function; beta cell-specific deletion of Wtap induces severe hyperglycemia, beta cell failure, and diabetes. WTAP deficiency decreases m6A mRNA modification and reduces expression of beta cell-specific transcription factors and insulin secretion-related genes by reducing METTL3 protein levels. Beta cell-specific overexpression of Mettl3 partially reverses these abnormalities. Beta cell-specific Wtap knockout, Mettl3 overexpression rescue, glucose tolerance/GSIS assays, RNA-seq, MeRIP-seq Diabetologia High 36920524
2022 Loss of Wtap in Purkinje cells causes early-onset cerebellar ataxia, cerebellar atrophy, extensive Purkinje cell degeneration and apoptosis, and aberrant degradation of PC synapses. WTAP depletion decreases METTL3/14 protein levels and reduces m6A methylation in Purkinje cells. Purkinje cell-specific Wtap knockout, behavioral ataxia testing, histological analysis, western blot for METTL3/14, m6A methylation quantification Journal of genetics and genomics High 35304325
2022 WTAP deficiency in cardiomyocytes induces dilated cardiomyopathy and heart failure. Unlike in other tissues, WTAP deficiency in the heart decreases chromatin accessibility at promoters of Mef2a and Mef2c, reducing their expression. WTAP directly binds to the Mef2c gene promoter and increases its promoter activity (demonstrated by luciferase assay). Cardiomyocyte-specific overexpression of Mettl3 does not rescue the phenotypes, indicating this cardiac function is m6A-independent. Cardiomyocyte-specific Wtap knockout, Mettl3 overexpression rescue experiment (negative result for rescue), chromatin accessibility assay (ATAC-seq), luciferase promoter assay, ChIP Journal of molecular and cellular cardiology High 38224851
2022 During HCV infection, WTAP (normally a predominantly nuclear protein) is relocalized to the cytoplasm. WTAP is required for both METTL3 interaction with HCV RNA and m6A modification across the viral RNA genome in the cytoplasm. WTAP, METTL3, and METTL14 negatively regulate production of infectious HCV virions. WTAP's regulation of HCV RNA m6A modification and virion production is independent of its nuclear localization. Subcellular fractionation, RIP with HCV RNA, m6A sequencing of viral RNA, WTAP knockdown/rescue with nuclear-localization mutants, infectious virus production assays Journal of virology High 36314819
2021 WTAP-mediated m6A modification of ETS1 mRNA leads to post-transcriptional suppression of ETS1 with involvement of HuR as an RNA stabilizer. WTAP promotes HCC cell proliferation and G2/M cell cycle arrest through the HuR-ETS1-p21/p27 axis. m6A dot blot, MeRIP assay, RNA immunoprecipitation (RIP) assay, dual luciferase reporter assay, ChIP assay, RNA-seq, WTAP knockdown/overexpression Molecular cancer Medium 31438961
2021 circ0008399 binds WTAP protein to promote formation of the WTAP/METTL3/METTL14 m6A methyltransferase complex, increasing its assembly and activity and promoting m6A-dependent stabilization of TNFAIP3 mRNA, thereby reducing cisplatin sensitivity in bladder cancer. RNA pulldown, RIP assay, MeRIP assay, Co-IP for complex assembly, functional cisplatin sensitivity assays Cancer research Medium 34702726
2021 circPDE5A forms a complex with WTAP (verified by RNA pulldown and RIP) and blocks WTAP-dependent m6A methylation of EIF3C mRNA, disrupting EIF3C translation and inactivating the MAPK pathway to restrain prostate cancer metastasis. RNA pulldown followed by mass spectrometry, RIP, MeRIP-seq, in vitro and in vivo functional assays Journal of experimental & clinical cancer research Medium 35650605
2021 WTAP promotes m6A modification of NLRP3 mRNA to upregulate NLRP3 inflammasome activation, leading to cell pyroptosis and inflammation in diabetic nephropathy. WTAP-mediated m6A stabilization of NLRP3 mRNA is recognized by IGF2BP1. Histone acetyltransferase p300 regulates WTAP expression upstream. WTAP knockdown/overexpression, MeRIP assay, RIP assay, m6A dot blot, IGF2BP1 RIP, p300 inhibitor (C646) treatment Cellular & molecular biology letters Medium 35761192
2022 WTAP-mediated m6A modification of lncRNA DIAPH1-AS1 enhances its stability through the m6A reader IGF2BP2. DIAPH1-AS1 acts as a molecular adaptor promoting MTDH-LASP1 complex formation and LASP1 upregulation, facilitating NPC growth and metastasis. KAT3A-mediated H3K27 acetylation fine-tunes WTAP expression in NPC. MeRIP assay, RIP assay, IGF2BP2 binding assay, Co-IP (MTDH-LASP1), ChIP for H3K27ac, WTAP knockdown/overexpression Cell death and differentiation Medium 34999731
2022 WTAP increases in senescent nucleus pulposus cells due to KDM5a-mediated epigenetic increase in H3K4me3 at the WTAP promoter. WTAP promotes m6A modification of lncRNA NORAD, leading to YTHDF2-mediated decay of NORAD. Reduced NORAD leads to less sequestration of PUMILIO proteins, augmenting PUM1/2 activity and repressing E2F3 mRNA, promoting cellular senescence and IVDD. m6A sequencing (m6A-seq), gain/loss-of-function experiments, ChIP for H3K4me3, MeRIP, YTHDF2 RIP, functional senescence assays Nature communications Medium 35304463
2021 C5aR1-positive neutrophil-secreted IL1β and TNFα cooperatively activate ERK1/2 signaling, which phosphorylates WTAP at serine 341, stabilizing the WTAP protein. Stabilized WTAP then promotes m6A methylation of ENO1 mRNA, increasing ENO1 expression and breast cancer cell glycolysis. ERK1/2 inhibition, phosphorylation site identification (S341), western blot for WTAP stability, MeRIP for ENO1 m6A, glycolysis assays, WTAP silencing in vivo Cell death & disease Medium 34312368
2022 WTAP promotes m6A modification of NORAD lncRNA and pri-miRNA processing: WTAP-mediated m6A modification of pri-miR-181a and pri-miR-181c is recognized by YTHDC1, increasing maturation to miR-181a/c. These miRNAs inhibit SFRP1 mRNA, promoting osteogenic differentiation of BMSCs via activation of Wnt signaling. Co-IP, RIP, MeRIP, RNA pulldown, dual-luciferase assay, ALP activity, Alizarin Red staining, micro-CT Cell death & disease Medium 36650131
2022 WTAP mediates m6A modification of ATF4 mRNA, regulating its expression, and thereby promotes endoplasmic reticulum stress and apoptosis in cardiomyocytes during hypoxia/reoxygenation. WTAP expression is time-dependently increased by H/R. The inhibitory effects of WTAP on ER stress and apoptosis are ATF4-dependent. WTAP knockdown/overexpression, MeRIP for ATF4 m6A, ER stress inhibitor (4-PBA) rescue, in vivo I/R model Aging Medium 33819187
2022 WTAP mediates m6A modification of FOXO3a mRNA through the m6A reader YTHDF1, enhancing FOXO3a mRNA stability and expression. This WTAP/YTHDF1/m6A/FOXO3a axis regulates myocardial I/R injury progression. MeRIP-seq identifying m6A site in 3'-UTR of FOXO3a, YTHDF1 RIP, RNA stability assay, WTAP knockdown in H9C2 cells and I/R rat model Apoptosis Medium 36894806
2022 WTAP deficiency in hepatocytes causes NASH by increasing lipolysis in white adipose tissue, enhancing hepatic free fatty acid uptake, and inducing inflammation. Mechanistically, WTAP binds specific DNA motifs in promoters and suppresses gene expression (Igfbp1, Cd36, Ccl2) with involvement of HDAC1. In NASH, CDK9-mediated phosphorylation of WTAP causes its translocation from nucleus to cytosol. Hepatocyte-specific Wtap knockout, ChIP for WTAP-DNA binding and HDAC1, CDK9 inhibitor/kinase assay, subcellular fractionation, gene expression profiling Nature communications High 35927268
2023 Hepatic deletion of Wtap promotes HCC progression. WTAP interacts with RNA polymerase II and H3K9ac to maintain expression of proteasome-related genes (Psmb4, Psmb6). WTAP deficiency decreases proteasome gene expression, increasing protein stability of GRB2 and ERK1/2, thereby activating the ERK signaling pathway and increasing hepatocyte proliferation. Hepatocyte-specific Wtap knockout, ChIP for RNA Pol II and H3K9ac at proteasome gene promoters, western blot for GRB2/ERK stability, PSMB4/PSMB6 restoration rescue experiments Journal of biological chemistry High 37777158
2023 PRMT1 methylates WTAP protein; this methylation is required for WTAP-dependent m6A modification of NDUFS6 mRNA. PRMT1 knockdown reduces OXPHOS in multiple myeloma cells through NDUFS6 downregulation, and this is mediated via WTAP. Co-IP to identify WTAP-PRMT1 interaction, methylation assay, MeRIP for NDUFS6 m6A, PRMT1 knockdown/overexpression, in vitro and in vivo functional assays Cell death & disease Medium 37558663
2023 HIF1α directly binds the hypoxia-response element of the WTAP gene promoter and transactivates WTAP expression in t(8;21) AML. Elevated WTAP increases m6A modification of KDM4B transcripts, promoting their translation; this drives crosstalk between m6A RNA methylation and histone H3K9 trimethylation. ChIP (HIF1α binding to WTAP HRE), m6A profiling (transcriptome-wide), KDM4B knockdown, pharmacological/genetic HIF1α intervention, in vitro and in vivo AML models Leukemia Medium 37087529
2022 TTC22 directly interacts with the 60S ribosomal protein RPL4, which promotes binding of WTAP mRNA to RPL4 and enhances WTAP mRNA stability and translation efficiency. WTAP mRNA is itself an m6A target recognized by YTHDF1, and TTC22 triggers a positive feedback loop between WTAP protein expression and WTAP mRNA m6A modification. Co-IP (TTC22-RPL4), RIP (YTHDF1-WTAP mRNA), m6A MeRIP, WTAP mRNA stability assay, YTHDF1 knockdown, luciferase reporter Oncogene Medium 35798874
2022 WTAP-mediated m6A modification of WTAP's target mRNAs promotes maturation of pri-miR-92b to miR-92b-5p in an m6A-dependent manner; m6A modification also directly facilitates YTHDF2-dependent degradation of TIMP4 mRNAs. Both mechanisms contribute to OA progression. MeRIP, RIP for DGCR8 (microprocessor) and YTHDF2, pri-miRNA processing assay, WTAP knockdown/overexpression, DMM mouse model Cell communication and signaling Medium 37563688
2022 WTAP interacts with DGCR8 (microprocessor component) and accelerates maturation of pri-miR-29b-3p in an m6A-dependent manner, increasing miR-29b-3p levels, which inhibit HDAC4 expression to promote osteogenic and inhibit adipogenic differentiation of BMSCs. Co-IP (WTAP-DGCR8), MeRIP for pri-miR-29b, dual-luciferase (miR-29b-3p binding to HDAC4), differentiation assays, in vivo mouse model Stem cells translational medicine Medium 37010483
2022 WTAP interacts with DGCR8 to regulate microRNA-200 processing in an m6A-dependent way; miR-200 positively regulates glycolysis enzyme HK2, accelerating the Warburg effect in ovarian cancer. WTAP expression is positively regulated by HIF-1α under hypoxia. Co-IP (WTAP-DGCR8), MeRIP for pri-miR-200 m6A, functional glycolysis assays, HIF-1α knockdown/OE, WTAP KD/OE Journal of immunology research Medium 35733918
2022 WTAP affects SUV39H1 mRNA m6A methylation, reducing H3K9me3 enrichment at the CCL2 promoter, thereby promoting CCL2 secretion and macrophage recruitment during corneal neovascularization. Separately, WTAP regulates translational efficiency of HIF-1α via m6A modification. MeRIP (SUV39H1 mRNA), ChIP (H3K9me3 at CCL2 promoter), WTAP knockdown/AAV overexpression in vivo, tube formation assay Biochimica et biophysica acta. Molecular basis of disease Medium 37019244
2022 EP3 receptor activation prevents ubiquitin-mediated proteasomal degradation of WTAP by eliminating PKA-mediated ERK1/2 inhibition during brown adipocyte differentiation, thereby stabilizing WTAP protein. Stabilized WTAP then mediates m6A modification of Zfp410 mRNA, stabilizing it and promoting brown adipogenesis. EP3 knockout mouse, brown adipocyte-specific WTAP KO, ubiquitination assay, PKA inhibition, ERK1/2 phosphorylation analysis, MeRIP (Zfp410), in vivo BAT formation assay EMBO journal High 35781818
2023 p65 (NF-κB subunit) transcriptionally regulates WTAP expression; elevated WTAP is more prone to phase separation, facilitating aggregation of the m6A writer complex to nuclear speckles and deposition of m6A marks on inflammatory transcripts, accelerating proinflammatory responses. Myeloid-specific WTAP deficiency attenuates LPS-induced sepsis and DSS-induced IBD. Myeloid-specific Wtap KO mouse, p65 ChIP on WTAP promoter, phase separation assay, m6A sequencing, functional inflammatory models (LPS sepsis, DSS colitis) Journal of clinical investigation High 39007267
2023 A cleaved form of METTL3 (METTL3a, residues 239-580) is required for the METTL3-WTAP interaction. METTL3a is essential for the METTL3-METTL3 interaction, which is a prerequisite step for recruitment of WTAP into the MTC. METTL3 cleavage is mediated by the proteasome in an mTOR-dependent manner, revealing positive regulatory feedback. Identification of METTL3a by mass spectrometry, Co-IP (METTL3a-WTAP, METTL3-METTL3), m6A sequencing, mTOR inhibition, proteasome inhibition, mutagenesis eLife High 37589705
2023 WTAP-mediated m6A modification of AR (androgen receptor) mRNA induces its degradation in a YTHDF2-dependent manner. AR directly interacts with mitochondrial lipid oxidation enzyme Decr1; AR overexpression suppresses Decr1-mediated mitochondrial lipid oxidation, inhibiting cardiac fibroblast proliferation and migration. WTAP thus promotes diabetic cardiac fibrosis by boosting mitochondrial lipid oxidation through AR methylation. MeRIP for AR m6A, YTHDF2 RIP/KD, Co-IP (AR-Decr1), mitochondrial lipid oxidation assay, cardiac fibroblast functional assays, human DCM tissue analysis iScience Medium 37810250
2023 WTAP mediates m6A modification of TNFAIP3 mRNA and ENO1 mRNA (m6A-dependent stabilization), VEGFA mRNA (promoting MAPK signaling via YTHDC1 as reader), and promotes cancer glycolysis; WTAP mediates m6A modification of FOXP3 mRNA (stabilized via YTHDF1); multiple cancer-specific targets established. MeRIP-seq + RNA-seq, YTHDC1/YTHDF1 RIP, tube formation assay, WTAP KD/OE in CRC cells FASEB journal Medium 37428639
2025 OGT-mediated O-GlcNAcylation and USP7-mediated de-ubiquitination synergistically enhance WTAP protein stability in GBM. Stabilized WTAP promotes LOXL2 mRNA m6A modification, enhancing its stability via IGF2BP2 and increasing secreted LOXL2 (sLOXL2). sLOXL2 activates integrin α5β1-FAK-ERK signaling in GSCs (mesenchymal transition) and in MDMs (M2 polarization), promoting immune evasion. Mass spectrometry (O-GlcNAcylation sites), Co-IP (WTAP-USP7, WTAP-OGT), RIP (IGF2BP2-LOXL2), MeRIP, integrin signaling pathway analysis, single-cell RNA-seq Neuro-oncology Medium 39671515
2021 WTAP knockdown in porcine parthenogenetic zygotes significantly reduces blastocyst rate and global m6A levels without affecting cleavage rate, and downregulates pluripotency genes (OCT4, SOX2, NANOG) while upregulating apoptotic genes (BAX, CASPASE3), demonstrating WTAP is required for early embryonic development through m6A modification. Microinjection of si-WTAP into porcine zygotes, m6A quantification, TUNEL staining, qPCR for pluripotency/apoptosis genes Animals Medium 34199793
2024 WTAP directly acts on NLRP3 mRNA, regulates its m6A level, and promotes NLRP3 protein expression after neuronal injury via YTHDF1. YTHDF1 directly binds NLRP3 mRNA and regulates NLRP3 protein translation. Conditional neuron-specific Wtap knockout suppresses neuroinflammation after TBI. Conditional Wtap knockout (flox/flox, Camk2a-cre), AAV-shYTHDF1, RIP (YTHDF1-NLRP3 mRNA), MeRIP (NLRP3 m6A), neurological function assays International journal of surgery Medium 38874470
2024 IFN-γ activates ERK signaling in MSCs, inducing WTAP phosphorylation and stabilizing WTAP post-transcriptionally. Stabilized WTAP increases m6A modification and mRNA stability of immunosuppressive molecules (IDO1, PD-L1, ICAM1, VCAM1) in a YTHDF1-dependent manner, amplifying the immunosuppressive capacity of IFN-γ-licensed MSCs. Epitranscriptomic microarray, MeRIP-qPCR, RIP-qPCR, RNA stability assay, ERK inhibition, western blot, functional T cell suppression assay, DSS colitis and CIA in vivo models Journal of advanced research Medium 38944238

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell research 1963 24407421
2019 WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1. Molecular cancer 529 31438961
2018 Interactions, localization, and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex. RNA (New York, N.Y.) 383 29348140
2021 Circ0008399 Interaction with WTAP Promotes Assembly and Activity of the m6A Methyltransferase Complex and Promotes Cisplatin Resistance in Bladder Cancer. Cancer research 152 34702726
2022 WTAP-mediated m6A modification of lncRNA DIAPH1-AS1 enhances its stability to facilitate nasopharyngeal carcinoma growth and metastasis. Cell death and differentiation 142 34999731
2022 WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration. Nature communications 137 35304463
2018 The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis. Molecular and cellular biology 134 29866655
2018 METTL3 regulates WTAP protein homeostasis. Cell death & disease 121 30038300
2022 The RNA m6A writer WTAP in diseases: structure, roles, and mechanisms. Cell death & disease 116 36207306
2020 WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 expression in an m6A-dependent manner. Cell death & disease 113 32814762
2022 WTAP-mediated N6-methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy. Cellular & molecular biology letters 112 35761192
2021 WTAP promotes myocardial ischemia/reperfusion injury by increasing endoplasmic reticulum stress via regulating m6A modification of ATF4 mRNA. Aging 87 33819187
2021 C5aR1-positive neutrophils promote breast cancer glycolysis through WTAP-dependent m6A methylation of ENO1. Cell death & disease 87 34312368
2013 WTAP regulates migration and invasion of cholangiocarcinoma cells. Journal of gastroenterology 80 23354623
2022 The function of Wtap in N6-adenosine methylation of mRNAs controls T cell receptor signaling and survival of T cells. Nature immunology 73 35879451
2023 WTAP-mediated m6A modification modulates bone marrow mesenchymal stem cells differentiation potential and osteoporosis. Cell death & disease 64 36650131
2023 m6A writer WTAP targets NRF2 to accelerate bladder cancer malignancy via m6A-dependent ferroptosis regulation. Apoptosis : an international journal on programmed cell death 63 36719469
2022 circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA. Journal of experimental & clinical cancer research : CR 60 35650605
2024 WTAP participates in neuronal damage by protein translation of NLRP3 in an m6A-YTHDF1-dependent manner after traumatic brain injury. International journal of surgery (London, England) 52 38874470
2022 Role of WTAP in Cancer: From Mechanisms to the Therapeutic Potential. Biomolecules 48 36139062
2008 Wtap is required for differentiation of endoderm and mesoderm in the mouse embryo. Developmental dynamics : an official publication of the American Association of Anatomists 47 18224709
2020 WTAP Function in Sertoli Cells Is Essential for Sustaining the Spermatogonial Stem Cell Niche. Stem cell reports 45 33053361
2021 WTAP facilitates progression of endometrial cancer via CAV-1/NF-κB axis. Cell biology international 43 33559954
2023 PRMT1 methylation of WTAP promotes multiple myeloma tumorigenesis by activating oxidative phosphorylation via m6A modification of NDUFS6. Cell death & disease 42 37558663
2021 Hypoxia induces chemoresistance of esophageal cancer cells to cisplatin through regulating the lncRNA-EMS/miR-758-3p/WTAP axis. Aging 42 34081626
2021 LINC00839/miR-144-3p/WTAP (WT1 Associated protein) axis is involved in regulating hepatocellular carcinoma progression. Bioengineered 42 34634995
2022 HIF-1α Regulated WTAP Overexpression Promoting the Warburg Effect of Ovarian Cancer by m6A-Dependent Manner. Journal of immunology research 41 35733918
2022 Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH). Nature communications 39 35927268
2022 WTAP Targets the METTL3 m6A-Methyltransferase Complex to Cytoplasmic Hepatitis C Virus RNA to Regulate Infection. Journal of virology 38 36314819
2022 WTAP-mediated m6A modification on circCMTM3 inhibits hepatocellular carcinoma ferroptosis by recruiting IGF2BP1 to increase PARK7 stability. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 37 36586770
2022 PGE2 -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase. The EMBO journal 34 35781818
2024 WTAP weakens oxaliplatin chemosensitivity of colorectal cancer by preventing PANoptosis. Cancer letters 33 39270768
2024 WTAP-mediated m6A modification of FRZB triggers the inflammatory response via the Wnt signaling pathway in osteoarthritis. Experimental & molecular medicine 32 38172596
2024 Elevated WTAP promotes hyperinflammation by increasing m6A modification in inflammatory disease models. The Journal of clinical investigation 31 39007267
2023 WTAP activates MAPK signaling through m6A methylation in VEGFA mRNA-mediated by YTHDC1 to promote colorectal cancer development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 31 37428639
2023 WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation. iScience 31 37810250
2020 WTAP Gene Variants Confer Hepatoblastoma Susceptibility: A Seven-Center Case-Control Study. Molecular therapy oncolytics 30 32671187
2024 WTAP/IGF2BP3 mediated m6A modification of the EGR1/PTEN axis regulates the malignant phenotypes of endometrial cancer stem cells. Journal of experimental & clinical cancer research : CR 29 39044249
2023 m6A methyltransferase WTAP regulates myocardial ischemia reperfusion injury through YTHDF1/FOXO3a signaling. Apoptosis : an international journal on programmed cell death 29 36894806
2023 Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice. Diabetologia 29 36920524
2021 MicroRNA-501-3p inhibits the proliferation of kidney cancer cells by targeting WTAP. Cancer medicine 29 34595849
2023 WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis. Stem cells translational medicine 28 37010483
2023 N6-methyladenosine (m6A) methyltransferase WTAP-mediated miR-92b-5p accelerates osteoarthritis progression. Cell communication and signaling : CCS 28 37563688
2021 HIV Replication Is Increased by RNA Methylation METTL3/METTL14/WTAP Complex Activators. ACS omega 28 34179640
2023 Lactoferrin suppresses the progression of colon cancer under hyperglycemia by targeting WTAP/m6A/NT5DC3/HKDC1 axis. Journal of translational medicine 27 36855062
2024 WTAP-mediated m6A modification of lncRNA Snhg1 improves myocardial ischemia-reperfusion injury via miR-361-5p/OPA1-dependent mitochondrial fusion. Journal of translational medicine 26 38796415
2022 Plumbagin rescues the granulosa cell's pyroptosis by reducing WTAP-mediated N6-methylation in polycystic ovary syndrome. Journal of ovarian research 25 36463191
2022 WTAP dysregulation-mediated HMGN3-m6A modification inhibited trophoblast invasion in early-onset preeclampsia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24 36412513
2024 Regulation of ULK1 by WTAP/IGF2BP3 axis enhances mitophagy and progression in epithelial ovarian cancer. Cell death & disease 23 38286802
2022 WTAP mediates the anti-inflammatory effect of Astragalus mongholicus polysaccharide on THP-1 macrophages. Frontiers in pharmacology 23 36278233
2023 HIF1α-mediated transactivation of WTAP promotes AML cell proliferation via m6A-dependent stabilization of KDM4B mRNA. Leukemia 22 37087529
2022 Upregulated WTAP expression appears to both promote breast cancer growth and inhibit lymph node metastasis. Scientific reports 22 35046505
2022 TTC22 promotes m6A-mediated WTAP expression and colon cancer metastasis in an RPL4 binding-dependent pattern. Oncogene 22 35798874
2023 WTAP promotes macrophage recruitment and increases VEGF secretion via N6-methyladenosine modification in corneal neovascularization. Biochimica et biophysica acta. Molecular basis of disease 21 37019244
2023 WTAP regulates autophagy in colon cancer cells by inhibiting FLNA through N6-methyladenosine. Cell adhesion & migration 20 36849408
2021 ARRB2 promotes colorectal cancer growth through triggering WTAP. Acta biochimica et biophysica Sinica 20 33367479
2021 N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) mitigates the liver fibrosis via WTAP/m6A/Ptch1 axis through Hedgehog pathway. Gene 20 34921949
2024 WTAP-mediated N6-methyladenosine modification promotes the inflammation, mitochondrial damage and ferroptosis of kidney tubular epithelial cells in acute kidney injury by regulating LMNB1 expression and activating NF-κB and JAK2/STAT3 pathways. Journal of bioenergetics and biomembranes 19 38517565
2024 WTAP/YTHDF1-mediated m6A modification amplifies IFN-γ-induced immunosuppressive properties of human MSCs. Journal of advanced research 19 38944238
2022 WTAP regulates postnatal development of brown adipose tissue by stabilizing METTL3 in mice. Life metabolism 19 39872074
2021 Long Noncoding RNA DUXAP8 Promotes Pancreatic Carcinoma Cell Migration and Invasion Via Pathway by miR-448/WTAP/Fak Signaling Axis. Pancreas 19 33625109
2025 O-GlcNAcylation stabilized WTAP promotes GBM malignant progression in an N6-methyladenosine-dependent manner. Neuro-oncology 18 39671515
2024 Downregulation of Wtap causes dilated cardiomyopathy and heart failure. Journal of molecular and cellular cardiology 18 38224851
2024 WTAP-induced N6-methyladenosine of PD-L1 blocked T-cell-mediated antitumor activity under hypoxia in colorectal cancer. Cancer science 18 38508217
2024 WTAP/IGF2BP3-mediated GBE1 expression accelerates the proliferation and enhances stemness in pancreatic cancer cells via upregulating c-Myc. Cellular & molecular biology letters 18 38961325
2023 Caprin-1 plays a role in cell proliferation and Warburg metabolism of esophageal carcinoma by regulating METTL3 and WTAP. Journal of translational medicine 18 36855123
2023 The Emerging, Multifaceted Role of WTAP in Cancer and Cancer Therapeutics. Cancers 18 37297015
2023 A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression. eLife 18 37589705
2022 SNHG10/miR-141-3p/WTAP axis promotes osteosarcoma proliferation and migration. Journal of biochemical and molecular toxicology 18 35274397
2025 WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 17 40470706
2024 WTAP Mediated N6-methyladenosine RNA Modification of ELF3 Drives Cellular Senescence by Upregulating IRF8. International journal of biological sciences 17 38481803
2022 WTAP mediates FOXP3 mRNA stability to promote SMARCE1 expression and augment glycolysis in colon adenocarcinoma. Mammalian genome : official journal of the International Mammalian Genome Society 16 36173464
2021 Loss of WTAP Impairs Early Parthenogenetic Embryo Development. Animals : an open access journal from MDPI 16 34199793
2022 Roles of the m6A methyltransferases METTL3, METTL14, and WTAP in pulmonary tuberculosis. Frontiers in immunology 15 36569923
2024 Exosome-based WTAP siRNA delivery ameliorates myocardial ischemia-reperfusion injury. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 14 38367759
2024 WTAP-mediated m6A modification of TRIM22 promotes diabetic nephropathy by inducing mitochondrial dysfunction via ubiquitination of OPA1. Redox report : communications in free radical research 14 39314036
2022 ING2-WTAP is a potential therapeutic target in non-small cell lung cancer. Biochemical and biophysical research communications 14 35306362
2021 EBV downregulates the m6A "writer" WTAP in EBV-associated gastric carcinoma. Virus research 14 34329695
2024 WTAP-MEDIATED M6A MODIFICATION OF KLF6 AGGRAVATES HYPOXIA/REOXYGENATION-INDUCED HUMAN CARDIOMYOCYTE INJURY. Shock (Augusta, Ga.) 13 38662610
2022 Upregulated WTAP expression in colorectal cancer correlates with tumor site and differentiation. PloS one 13 35143566
2022 Loss of Wtap results in cerebellar ataxia and degeneration of Purkinje cells. Journal of genetics and genomics = Yi chuan xue bao 13 35304325
2021 Associations between WTAP gene polymorphisms and neuroblastoma susceptibility in Chinese children. Translational pediatrics 13 33633946
2020 WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2. Cell death & disease 13 32382056
2020 The contribution of WTAP gene variants to Wilms tumor susceptibility. Gene 13 32504654
2024 Marrow mesenchymal stem cell mediates diabetic nephropathy progression via modulation of Smad2/3/WTAP/m6A/ENO1 axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 12 38847786
2024 WTAP and METTL14 regulate the m6A modification of DKK3 in renal tubular epithelial cells of diabetic nephropathy. Biochemical and biophysical research communications 12 39151294
2023 WTAP-Involved the m6A Modification of lncRNA FAM83H-AS1 Accelerates the Development of Gastric Cancer. Molecular biotechnology 12 37477820
2024 The lncRNAMALAT1-WTAP axis: a novel layer of EMT regulation in hypoxic triple-negative breast cancer. Cell death discovery 11 38862471
2023 AGAP2-AS1 promotes the assembly of m6A methyltransferases and activation of the IL6/STAT3 pathway by binding with WTAP in the carcinogenesis of gastric cancer. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 11 37983949
2003 Exclusion of WTAP and HOXA13 as candidate genes for isolated hypospadias. Scandinavian journal of urology and nephrology 11 14675924
2024 Abnormal stress promotes intervertebral disc degeneration through WTAP/YTHDF2-dependent TIMP3 m6A modification. Journal of cellular physiology 10 38345407
2024 N6-methyladenosine (m6A) Writer WTAP Potentiates Hepatocellular Carcinoma Immune Evasion and Aerobic Glycolysis. Cell biochemistry and biophysics 10 38872051
2023 Hepatocyte-specific Wtap deficiency promotes hepatocellular carcinoma by activating GRB2-ERK depending on downregulation of proteasome-related genes. The Journal of biological chemistry 10 37777158
2024 SETD1A-mediated Methylation of H3K4me3 Inhibits Ferroptosis in Non-small Cell Lung Cancer by Regulating the WTAPP1/WTAP Axis. Current medicinal chemistry 9 37231753
2024 WTAP promotes proliferation of esophageal squamous cell carcinoma via m6A-dependent epigenetic promoting of PTP4A1. Cancer science 9 38746998
2024 WTAP and m6A-modified circRNAs modulation during stress response in acute myeloid leukemia progenitor cells. Cellular and molecular life sciences : CMLS 9 38909325
2024 WTAP promotes fibroblast-like synoviocyte pyroptosis in Rheumatoid arthritis by upregulating N6-methyladenosine modification of NLRP3. Journal of bioenergetics and biomembranes 9 39187680
2023 EXOSC2 Mediates the Pro-tumor Role of WTAP in Breast Cancer Cells via Activating the Wnt/β-Catenin Signal. Molecular biotechnology 9 37856011
2022 A potential biomarker of esophageal squamous cell carcinoma WTAP promotes the proliferation and migration of ESCC. Pathology, research and practice 9 36095919
2024 WTAP-dependent N6-methyladenosine methylation of lncRNA TEX41 promotes renal cell carcinoma progression. Scientific reports 8 39433619

Missed literature

Know a paper Affinage missed for WTAP? Flag it for the maintainers and the community.

No submissions yet.