Affinage

WNT7A

Protein Wnt-7a · UniProt O00755

Length
349 aa
Mass
39.0 kDa
Annotated
2026-06-11
100 papers in source corpus 42 papers cited in narrative 42 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

WNT7A is a secreted glycoprotein morphogen that orchestrates tissue patterning, stem-cell behavior, and synaptic and vascular development by engaging distinct Frizzled receptor complexes that route signaling into both canonical β-catenin/TCF and several non-canonical effector pathways (PMID:7885472, PMID:12857724, PMID:19497282). In development, dorsal-ectoderm WNT7A acts as a dorsalizing signal for limb mesoderm, operating upstream of the LIM homeodomain factor Lmx1b and maintaining posterior Shh expression, with genetic epistasis showing it signals through the LRP6/β-catenin axis antagonized by Dkk1 (PMID:7885472, PMID:7585966, PMID:7697724, PMID:15880584, PMID:15242796); it likewise maintains Müllerian-duct and uterine patterning through control of the MIS receptor and Hox genes (PMID:9790192, PMID:9671592). WNT7A drives satellite stem-cell symmetric expansion and directional migration through a Fzd7/Syndecan-4 co-receptor complex that activates the planar-cell-polarity effector Vangl2 and Dvl2/Rac1, and induces myofibre hypertrophy through a Fzd7–Gαs–PI3K complex activating Akt/mTOR independently of IGF signaling (PMID:19497282, PMID:23290138, PMID:24711502, PMID:22179044). In neurons, WNT7A signaling through Fzd5 and Dishevelled inhibits GSK-3β—dephosphorylating MAP-1B—and activates CaMKII to promote axonal remodeling, excitatory synaptogenesis, and dendritic spine growth (PMID:9570753, PMID:20530549, PMID:21670302, PMID:10721990). In CNS vasculature, WNT7A signaling requires the obligate co-receptors Reck and Gpr124, which assemble with Frizzled to maintain blood-brain barrier integrity and CNS angiogenesis; specific Wnt7a residues and the Reck CC4 domain mediate this interaction (PMID:28803732, PMID:31225798, PMID:30478038). In epithelial and cancer contexts WNT7A engages Fzd5/Fzd9/Fzd10 to drive β-catenin/TCF transcription of targets such as FGF1 and MMP7, or non-canonical JNK/ERK5/PPARγ and TGFβ-potentiating programs, with context-dependent tumor-suppressive or tumor-promoting and fibroblast-activating effects (PMID:22232518, PMID:25174399, PMID:15705594, PMID:16835228, PMID:26777421).

Mechanistic history

Synthesis pass · year-by-year structured walk · 26 steps
  1. 1995 High

    Established WNT7A's foundational developmental role: it was unknown what signal dorsalized the limb, and knockout/misexpression showed WNT7A is the dorsal-ectoderm cue acting upstream of Lmx1 and maintaining Shh.

    Evidence Loss-of-function mouse knockout and retroviral misexpression/ectoderm ablation in chick limb

    PMID:7585966 PMID:7697724 PMID:7885472

    Open questions at the time
    • Receptor and co-receptor mediating limb signaling not yet identified
    • Signal transduction branch (canonical vs non-canonical) undefined at this stage
  2. 1997 High

    Placed WNT7A in a genetic hierarchy and revealed a neuronal signaling mechanism: En-1 represses Wnt-7a which induces Lmx-1b, while in neurons WNT7A acts upstream of GSK-3β inhibition to remodel axons.

    Evidence Double-mutant mouse genetics and primary cerebellar granule cell cultures with lithium epistasis

    PMID:9362463 PMID:9405095

    Open questions at the time
    • Direct GSK-3β substrate in neurons not yet defined
    • Receptor mediating neuronal effect unknown
  3. 1998 High

    Identified a direct downstream substrate and broadened the physiological scope: WNT7A inhibition of GSK-3β removes phospho-MAP-1B, and WNT7A maintains reproductive-tract patterning via MIS-receptor and Hox gene control.

    Evidence In vitro kinase assay plus neuron cultures; Wnt-7a knockout mice with in situ hybridization

    PMID:9570753 PMID:9671592 PMID:9790192

    Open questions at the time
    • How WNT7A reaches GSK-3β (receptor/Dvl link) not established
    • Mechanism of MIS-receptor induction in mesenchyme unknown
  4. 2000 High

    Demonstrated WNT7A is a bona fide synaptogenic factor: secreted WNT7A drives presynaptic differentiation and its loss delays synaptic maturation in vivo.

    Evidence Recombinant/conditioned-medium treatment, sFRP-1 blockade, and Wnt-7a knockout cerebellar analysis

    PMID:10721990

    Open questions at the time
    • Receptor mediating synaptogenesis not yet identified
    • Postsynaptic effectors undefined
  5. 2003 Medium

    Began defining receptor specificity and pathway bifurcation: WNT7A activates β-catenin/TCF through a Fzd5/LRP6 complex and induces E-cadherin in epithelial cells, antagonized by Dickkopfs.

    Evidence TCF-luciferase reporter assays and recombinant WNT7A treatment in PC12 and lung cancer cells

    PMID:12857724 PMID:12937339

    Open questions at the time
    • Direct Wnt7a-Fzd5 binding not yet demonstrated
    • Single-lab, cell-line dependent
  6. 2004 Medium

    Showed cell-type-dependent dual outputs: in chondrocytes WNT7A both drives β-catenin-dependent dedifferentiation and protects against apoptosis via PI3K/Akt.

    Evidence Primary chondrocyte cultures with β-catenin reporter and PI3K/Akt inhibitors

    PMID:15082716

    Open questions at the time
    • Receptor mediating each branch unidentified
    • Mechanism linking WNT7A to PI3K not defined here
  7. 2005 High

    Resolved canonical-pathway involvement in limb development and uncovered a non-canonical Fzd9 branch: genetic Dkk1/Lrp6 epistasis confirmed canonical signaling in limb, while a direct WNT7A-Fzd9 interaction activates JNK without β-catenin in lung cancer.

    Evidence Triple-mutant mouse genetics; Co-IP and JNK reporter assays in NSCLC cells; corneal Rac/MMP-12 assays

    PMID:15242796 PMID:15705594 PMID:15802269 PMID:15880584

    Open questions at the time
    • How a single ligand chooses canonical vs JNK output mechanistically unresolved
    • Fzd9 binding interface uncharacterized
  8. 2006 Medium

    Defined a non-canonical effector cascade: WNT7A/Fzd9 acts through ERK5 to activate PPARγ, suppressing transformed growth in lung cancer.

    Evidence ERK5 and PPARγ reporter assays with pharmacological inhibitors in NSCLC cells

    PMID:16835228

    Open questions at the time
    • Link between Fzd9 and ERK5 activation undefined
    • Single lab, cell line
  9. 2008 Medium

    Provided biochemical receptor binding and multi-Frizzled branching: purified WNT7A binds the Fzd5 CRD with nanomolar affinity, and in endometrial cells Fzd5 routes canonical while Fzd10 routes JNK signaling, both suppressed by SFRP4.

    Evidence ELISA binding and split-eGFP assays; Co-IP and pathway-specific reporters in Ishikawa cells

    PMID:18230341 PMID:18567805

    Open questions at the time
    • Structural basis of selective pathway engagement unresolved
    • In vivo relevance of Fzd10 branch untested
  10. 2009 High

    Established the satellite-cell stem-expansion mechanism: WNT7A signals through Fzd7 via the PCP pathway and the effector Vangl2 to drive symmetric stem-cell expansion and enhance regeneration.

    Evidence Satellite cell culture with Fzd7/Vangl2 siRNA, binding assays, and in vivo overexpression

    PMID:19497282

    Open questions at the time
    • Co-receptor requirements not yet defined
    • Downstream cytoskeletal mechanism incomplete
  11. 2010 High

    Identified the synaptogenic receptor: Fzd5 mediates WNT7A-stimulated hippocampal synaptogenesis and is recruited to synapses in an activity-dependent manner.

    Evidence Synaptosome fractionation, Fz5 knockdown/dominant-negative CRD, and electrophysiology

    PMID:20530549

    Open questions at the time
    • Postsynaptic transduction not fully resolved here
    • How activity recruits Fz5 mechanistically unknown
  12. 2011 High

    Defined two muscle/neuronal mechanisms: a Fzd7-Gαs-PI3K complex activates Akt/mTOR hypertrophy independently of IGF, and postsynaptic Dvl1/CaMKII mediates WNT7A excitatory-synapse formation.

    Evidence Co-IP of Fzd7 complex and myofibre assays; Wnt7a-Dvl1 double knockout, CaMKII reporter and electrophysiology

    PMID:21670302 PMID:22179044

    Open questions at the time
    • How Fzd7 couples to Gαs not structurally defined
    • Connection between PCP and Akt/mTOR branches in muscle unresolved
  13. 2012 Medium

    Linked WNT7A to oncogenic transcriptional output: WNT7A/FZD5/β-catenin activates the MMP7 promoter through TCF sites and promotes ovarian cancer invasion.

    Evidence TCF/LEF reporter, MMP7 promoter mutagenesis, siRNA and xenografts

    PMID:22232518

    Open questions at the time
    • Other direct target genes not mapped here
    • Single lab
  14. 2013 High

    Defined the satellite-cell niche co-receptor and ligand minimal unit: Fibronectin/Syndecan-4 partners with Fzd7, and a palmitoylation-site-lacking truncated WNT7A retains full PCP and Akt/mTOR activity with enhanced dispersion.

    Evidence Co-IP of Sdc4/Fzd7, niche FN knockdown/transplantation; truncated protein binding and functional assays

    PMID:23290138 PMID:24287629

    Open questions at the time
    • Role of lipidation in receptor selectivity not fully resolved
    • Stoichiometry of Fzd7/Sdc4/FN complex undefined
  15. 2013 High

    Extended WNT7A to neural stem-cell control: β-catenin/cyclin D1 drives proliferation while β-catenin/neurogenin-2 promotes neuronal differentiation in the dentate gyrus.

    Evidence Wnt7a knockout mouse with BrdU labeling, β-catenin reporter and neurosphere assays

    PMID:23629626

    Open questions at the time
    • Switch mechanism between proliferative and differentiative outputs unknown
    • Receptor identity in NSCs not defined
  16. 2014 High

    Expanded the regenerative and epithelial repertoire: WNT7A/Fzd7 drives Dvl2/Rac1 directional migration of satellite cells, transcriptionally controls FGF1 via β-catenin/TCF in cancer, and specifies corneal epithelial fate upstream of PAX6.

    Evidence siRNA epistasis and transplantation; ChIP and promoter mutagenesis; LSC differentiation with PAX6 rescue in vivo

    PMID:24711502 PMID:25030175 PMID:25174399

    Open questions at the time
    • Receptor mediating corneal PAX6 control not specified
    • Crosstalk between migration and expansion branches unresolved
  17. 2015 Medium

    Uncovered a β-catenin-independent tumor-suppressive mechanism: WNT7A induces senescence via SKP2 inactivation, with loss increasing lung tumorigenesis.

    Evidence Two Wnt7a-null strains, senescence markers, SKP2 assays and carcinogen model

    PMID:25728679

    Open questions at the time
    • Receptor and proximal signaling to SKP2 undefined
    • Single lab
  18. 2016 Medium

    Showed a stromal, β-catenin-independent oncogenic role: tumor-secreted WNT7A converts fibroblasts to CAFs and potentiates TGFβ signaling to drive metastasis.

    Evidence In vivo tumor models, 3D co-culture and TGFβ signaling assays

    PMID:26777421

    Open questions at the time
    • Receptor on fibroblasts unidentified
    • Mechanism of TGFβ potentiation undefined
  19. 2017 High

    Defined CNS vascular specificity: Reck and Gpr124 are obligate co-receptors assembling a Wnt7a/Frizzled complex needed for BBB integrity and CNS angiogenesis, with the Reck N-terminus binding Gpr124 LRR/Ig domains.

    Evidence EC-specific Reck knockout, interface mutagenesis, soluble probes and in vivo angiogenesis

    PMID:28803732

    Open questions at the time
    • Structural architecture of the full complex not resolved
    • How co-receptors confer ligand selectivity mechanistically incomplete
  20. 2018 High

    Mapped the molecular interface and a synaptic transcriptional arm: specific Wnt7a residue clusters and the Reck CC4 domain (P256/W261) are essential for CNS signaling, while neuronal GSK-3β/β-catenin/TCF drives PSD-95 and spine morphogenesis.

    Evidence Site-directed mutagenesis with in vivo validation; hippocampal neuron pharmacology and mouse behavior

    PMID:29967987 PMID:31225798

    Open questions at the time
    • How CC4 residues contact Wnt7a structurally undefined
    • Relative contribution of transcriptional vs local signaling at synapses unresolved
  21. 2018 High

    Demonstrated co-receptor redundancy in barrier maintenance: Wnt7a and Norrin/Fz4 systems partially overlap, and glia supply WNT7A for cerebellar BBB maintenance.

    Evidence Combinatorial conditional knockout mice and BBB permeability assays

    PMID:30478038

    Open questions at the time
    • Threshold integration mechanism between systems unknown
    • Endothelial responses to combined input undefined
  22. 2019 Medium

    Added a vascular receptor and effector: WNT7A acts through ROR2 to promote VEGFR2 Y1175 phosphorylation and tip-cell formation in pulmonary endothelium.

    Evidence Recombinant WNT7A, ROR2 siRNA, VEGFR2 phosphorylation and tip-cell assays plus Wnt7a-/- mice

    PMID:37024132

    Open questions at the time
    • Mechanism linking ROR2 to VEGFR2 phosphorylation undefined
    • Single lab
  23. 2020 Medium

    Defined an anti-adipogenic mechanism: WNT7A drives nuclear YAP/TAZ retention through Rho GTPase, β-catenin-independently, to suppress FAP adipogenesis and fatty infiltration.

    Evidence FAP cultures with YAP/TAZ localization, Rho inhibition, β-catenin knockdown and in vivo injection

    PMID:37001514

    Open questions at the time
    • Receptor coupling to Rho-YAP undefined
    • Single lab
  24. 2022 Medium

    Resolved species-divergent Gpr124 scaffolding: zebrafish Gpr124 uses intracellular Dvl-binding and ETTV/Dlg4/Magi3 motifs to deliver Reck-bound Wnt7a to Frizzled, while mammalian Gpr124 uses an ICD-independent mechanism.

    Evidence Zebrafish genetics, domain mutagenesis and Co-IP of Dvl/Dlg4/Magi3, cross-species comparison

    PMID:35649360

    Open questions at the time
    • Mammalian ICD-independent mechanism not fully defined
    • Single study
  25. 2023 Medium

    Established WNT7A as a fibrotic driver: basal-cell-derived WNT7A activates fibroblasts and inhibits AEC2 renewal, with neutralizing antibodies attenuating lung fibrosis.

    Evidence 3D organoids, conditioned medium, neutralizing antibodies/Frizzled inhibitor and bleomycin model with scRNA-seq

    PMID:36318668

    Open questions at the time
    • Fibroblast receptor mediating activation unidentified
    • Single lab
  26. 2024 Medium

    Demonstrated therapeutic restoration of barrier signaling: SARS-CoV-2 suppresses endothelial Wnt/β-catenin, and engineered cerebrovascular-targeted Wnt7a ligands restore BBB integrity and reduce cognitive deficits.

    Evidence Engineered ligand delivery in a mouse COVID-19 model with BBB, immune and behavioral readouts

    PMID:38306655

    Open questions at the time
    • Durability and dosing of engineered ligand undefined
    • Single study

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a single ligand selects among canonical β-catenin, PCP/Vangl2, Akt/mTOR, JNK/ERK5, Rho-YAP, and Reck/Gpr124-gated outputs in a cell-type-specific manner remains the central unresolved question.
  • No unifying structural model of ligand-receptor-co-receptor pathway selection
  • Stoichiometry and assembly order of Fzd/co-receptor complexes undefined
  • Determinants of canonical vs non-canonical branch choice per tissue unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0048018 receptor ligand activity 4 GO:0098772 molecular function regulator activity 3
Localization
GO:0005576 extracellular region 3 GO:0005886 plasma membrane 3
Pathway
R-HSA-112316 Neuronal System 4 R-HSA-1266738 Developmental Biology 4 R-HSA-162582 Signal Transduction 4 R-HSA-1643685 Disease 4
Partners
FZD5FZD7FZD9GPR124LRP6RECKROR2SDC4
Complex memberships
Fzd7/Gαs/PI3K complexFzd7/Syndecan-4 co-receptor complexWnt7a/Frizzled/Reck/Gpr124 CNS-vascular complex

Evidence

Reading pass · 42 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 Wnt-7a expressed in dorsal limb ectoderm acts as a dorsalizing signal for limb mesoderm; mice lacking Wnt-7a show dorsal-to-ventral transformations of cell fate in the distal limb and also lack posterior digits, demonstrating roles in both dorsal-ventral and anterior-posterior patterning. Loss-of-function mouse knockout; morphological and histological analysis of limb phenotypes Nature High 7885472
1995 Ectopic expression of Wnt7a in chick limb mesenchyme is sufficient to induce and maintain expression of the LIM homeodomain transcription factor LMX1 in dorsal limb mesenchyme; ectopic Lmx1 in ventral mesenchyme generates double-dorsal limbs, placing Wnt7a upstream of Lmx1 in the dorsoventral patterning cascade. Retroviral misexpression in chick limb bud in vivo and in vitro; genetic epistasis Cell High 7585966
1995 Wnt7a expressed in the dorsal ectoderm provides the signal required to maintain Shh expression in the posterior mesenchyme; removal of dorsal ectoderm causes loss of posterior skeletal elements rescued by exogenous SHH, demonstrating cross-talk between the dorsoventral (Wnt7a) and anteroposterior (Shh) signaling axes. Ectoderm removal surgery in chick limb bud; exogenous Shh rescue experiments Cell High 7697724
1997 WNT-7a increases axonal spreading and branching in cultured cerebellar granule cells and elevates levels of the presynaptic protein synapsin I; lithium mimics these effects by inhibiting GSK-3β, placing WNT-7a signaling upstream of GSK-3β inhibition in axonal remodeling. Primary granule cell culture treatment with WNT-7a protein; lithium treatment as GSK-3β inhibitor; immunofluorescence for synapsin I Developmental Biology High 9405095
1997 En-1 expressed in ventral ectoderm represses Wnt-7a, and Wnt-7a is required for Lmx-1b expression in distal limb mesenchyme; ectopic Wnt-7a in ventral ectoderm of En-1 mutants activates Lmx-1b in ventral mesenchyme and induces a second AER, demonstrating a genetic hierarchy: En-1 represses Wnt-7a which induces Lmx-1b for dorsal specification. Double-mutant mouse analysis (En-1–/–; Wnt-7a–/–); in situ hybridization; retroviral misexpression in chick Development High 9362463
1998 WNT-7a inhibits GSK-3β activity in cerebellar neurons, leading to loss of the phosphorylated (GSK-3β-dependent) form of microtubule-associated protein MAP-1B from axons and growth cones before morphological remodeling is evident; in vitro phosphorylation assay confirms MAP-1B is a direct GSK-3β substrate. In vitro kinase phosphorylation assay; cerebellar neuron cultures treated with WNT-7a or lithium; immunofluorescence for MAP-1B-P Journal of Cell Science High 9570753
1998 Wnt-7a is required for maintenance of Müllerian duct patterning in both sexes: male Wnt-7a knockout mice fail to undergo Müllerian duct regression due to absence of the MIS receptor (MISR2/AMHR2); female mutants develop abnormal oviducts and uteri. Wnt-7a is required for expression of the MIS receptor in Müllerian duct mesenchyme. Wnt-7a knockout mouse analysis; histology; in situ hybridization for MISR2 expression Nature High 9790192
1998 Wnt-7a signaling from uterine epithelium is required for maintenance of Hoxa-10 and Hoxa-11 expression in postnatal uterus; Wnt-7a mutant mice show posterior shifts in oviduct/uterine identity and disorganized uterine smooth muscle, indicating Wnt-7a maintains anteroposterior and radial patterning of the female reproductive tract. Wnt-7a knockout mouse; in situ hybridization; histology Development High 9671592
2000 Granule cell-secreted WNT-7a induces axon and growth cone remodeling in mossy fibers and clustering of synapsin I; this effect is blocked by the WNT antagonist sFRP-1; Wnt-7a mutant mice show delayed morphological maturation of glomerular rosettes and delayed synapsin I accumulation, establishing WNT-7a as a synaptogenic factor. Conditioned medium and recombinant WNT-7a treatment of mossy fiber neurons; sFRP-1 antagonist blockade; Wnt-7a knockout mouse cerebellar analysis; immunofluorescence Cell High 10721990
2003 WNT7A signals through a Frizzled-5/LRP6 receptor complex in PC12 cells to stabilize β-catenin and activate TCF-based transcription; this activity is antagonized by Dickkopf-1 and Dickkopf-3. Functional reporter assays (TCF-luciferase) in PC12 cells; receptor overexpression; treatment with Dickkopf proteins Journal of Biological Chemistry Medium 12857724
2003 WNT7a activates E-cadherin expression in lung cancer cells via a β-catenin-specific mechanism; WNT7a increases free β-catenin levels and E-cadherin; ZEB1 transcriptional repressor uniquely correlates with E-cadherin loss; a positive feedback loop involving WNT7a and E-cadherin exists. Recombinant WNT7a treatment of lung cancer cells; GSK-3β inhibitor (Li+) treatment; RNA interference of ZEB1; Western blot and reporter assays PNAS Medium 12937339
2004 Wnt-7a induces dedifferentiation of primary articular chondrocytes by stimulating β-catenin transcriptional activity; separately, Wnt-7a inhibits NO-induced apoptosis via activation of PI3K and Akt, demonstrating two distinct downstream pathways for Wnt-7a in chondrocytes. Primary chondrocyte cultures; β-catenin reporter assay; PI3K/Akt pathway inhibitors; apoptosis assays Journal of Biological Chemistry Medium 15082716
2005 WNT-7a acting through the Frizzled-9 receptor in non-small cell lung cancer cells reverses cellular transformation and induces epithelial differentiation; WNT-7a is present in Fzd-9 immunoprecipitates (direct interaction); WNT-7a/Fzd-9 activates the JNK pathway and induces E-cadherin and Sprouty-4 expression without activating β-catenin/TCF signaling. Co-immunoprecipitation; transfection of Fzd-9 into WNT-7a-insensitive cells; soft agar and 3D culture assays; JNK pathway reporter; Western blot Journal of Biological Chemistry Medium 15705594
2005 Wnt-7a rapidly induces accumulation of β-catenin and activation of Rac GTPase in corneal epithelial cells; Wnt-7a and Rac synergistically induce MMP-12 transcription, promoting cell proliferation and wound closure; blocking MMP-12 delays Wnt-7a-induced wound closure. Corneal epithelial cell culture treatment with Wnt-7a; β-catenin and Rac activation assays; MMP-12 function-blocking; wound closure assay Journal of Biological Chemistry Medium 15802269
2005 Genetic epistasis in mice shows that reducing Dkk1 (a canonical Wnt antagonist) in Wnt7a-null mice prevents digit loss, indicating Wnt7a acts through the canonical Wnt/β-catenin pathway during limb development. Double and triple mutant mouse analysis (Dkk1 hypomorph × Wnt7a null × En1 null); limb skeletal analysis Developmental Biology High 15242796
2005 Wnt7a acts through Lrp6 co-receptor to regulate Lmx1b expression during dorsal limb specification; Lrp6-null mice lack Lmx1b expression phenocopying Wnt7a mutants, and Wnt7a–/–;Lrp6+/– double mutants show severely increased loss of posterior skeletal elements, consistent with Wnt7a signaling through the canonical Lrp6/β-catenin pathway. Lrp6 knockout and Wnt7a/Lrp6 double-mutant mouse analysis; in situ hybridization for Lmx1b; skeletal preparation Developmental Dynamics High 15880584
2006 WNT-7a/Fzd-9 signaling in NSCLC cells activates ERK5, which in turn activates PPARγ; PPARγ inhibition blocks WNT-7a/Fzd-9-mediated suppression of anchorage-independent growth and E-cadherin induction, establishing an ERK5-PPARγ effector pathway downstream of WNT-7a/Fzd-9. ERK5 activation assays; PPARγ reporter assay; PPARγ inhibitor (SR202) treatment; soft agar growth assays in NSCLC cells Journal of Biological Chemistry Medium 16835228
2008 Wnt7a co-immunoprecipitates with Fzd5, Fzd10, and SFRP4 in Ishikawa endometrial cancer cells; Wnt7a binding to Fzd5 activates β-catenin/canonical signaling and increases proliferation, whereas Wnt7a binding to Fzd10 induces non-canonical JNK signaling; SFRP4 suppresses both pathways. Co-immunoprecipitation; β-catenin reporter assay; JNK pathway assay; SFRP4 overexpression; cell proliferation assay Molecular Cancer Research Medium 18567805
2008 Purified Wnt7a binds to the extracellular cysteine-rich domain of Fzd5 with nanomolar affinity as measured by ELISA-based binding assay; a split eGFP complementation assay visually confirms Wnt7a-Fzd5 interaction in cells. ELISA-based protein-protein binding assay; split eGFP complementation assay in cells Biochemical and Biophysical Research Communications Medium 18230341
2009 Wnt7a signals through Frizzled-7 (Fzd7) on satellite cells to drive symmetric expansion of satellite stem cells via the planar cell polarity (PCP) pathway; Wnt7a induces polarized distribution of the PCP effector Vangl2; silencing Fzd7 abrogates Wnt7a binding and stem cell expansion; silencing Vangl2 inhibits Wnt7a action; Wnt7a overexpression increases satellite stem cell numbers and muscle regeneration. Satellite cell isolation and culture; Fzd7 and Vangl2 siRNA knockdown; Wnt7a binding assay; in vivo overexpression; immunofluorescence for Vangl2 polarity Cell Stem Cell High 19497282
2010 Frizzled-5 (Fz5) mediates the synaptogenic effect of Wnt7a in hippocampal neurons; Fz5 is present in synaptosomes and co-localizes with synaptic markers; Fz5 knockdown or soluble Fz5-CRD domain blocks Wnt7a-stimulated synaptogenesis; neuronal activity recruits Fz5 to synapses in an endogenous Wnt-dependent manner. Synaptosome fractionation; Fz5 shRNA knockdown; soluble Fz5-CRD domain inhibition; high-frequency stimulation; immunofluorescence; electrophysiology Development High 20530549
2011 Wnt7a signaling through Fzd7 activates the Akt/mTOR anabolic growth pathway in differentiated myofibers, inducing hypertrophy; the Fzd7 receptor complex associates with Gαs and PI3K, which are required for Wnt7a-mediated Akt/mTOR activation; this pathway is completely independent of IGF-receptor activation. Co-immunoprecipitation of Fzd7 with Gαs and PI3K; genetic loss-of-function with siRNA; myofibre hypertrophy measurements; Akt/mTOR phosphorylation assays Nature Cell Biology High 22179044
2011 Wnt7a preferentially stimulates excitatory synapse formation in hippocampal neurons; postsynaptic Dishevelled-1 (Dvl1) expression mediates increased mEPSC frequency and amplitude; Wnt7a-Dvl1 deficient mice have defects in spine morphogenesis and mossy fiber-CA3 synaptic transmission; Wnt7a rapidly activates CaMKII in dendritic spines, and CaMKII inhibition abolishes Wnt7a effects on spine growth and excitatory synaptic strength. Electrophysiology (mEPSC/mIPSC recording); Dvl1 overexpression; Wnt7a-Dvl1 double knockout mouse; CaMKII activity reporter; pharmacological CaMKII inhibition; spine morphometry PNAS High 21670302
2012 WNT7A signals through FZD5 receptor and β-catenin/TCF pathway in ovarian cancer cells; co-transfection with FZD5 amplifies WNT7A-activated TCF/LEF reporter; WNT7A activates MMP7 promoter through TCF-binding sites; WNT7A knockdown reduces invasion and tumor lesions in vivo. TCF/LEF luciferase reporter; FZD5 co-transfection; MMP7 promoter mutation analysis; siRNA knockdown; xenograft mouse model Molecular Cancer Research Medium 22232518
2013 Fibronectin (FN) binds Syndecan-4 (Sdc4) to stimulate Wnt7a-induced satellite stem cell expansion; Sdc4 and Fzd7 form a co-receptor complex; newly activated satellite cells transiently upregulate FN to remodel their niche; FN knockdown impairs satellite cell niche repopulation; co-overexpression of FN with Wnt7a dramatically stimulates stem cell expansion in vivo. Co-immunoprecipitation of Sdc4/Fzd7; siRNA knockdown of FN, Sdc4, Fzd7; in vivo overexpression; satellite cell transplantation assays Cell Stem Cell High 23290138
2013 A truncated C-terminal Wnt7a variant (137 amino acids) lacking conserved palmitoylation sites retains full biological activity: it binds Fzd7, activates PCP-mediated satellite stem cell symmetric expansion and AKT/mTOR-mediated myofibre hypertrophy, and shows enhanced secretion and dispersion compared to full-length Wnt7a. Truncated protein generation; Fzd7 binding assay; satellite cell expansion assay; myofibre hypertrophy measurement; AKT/mTOR phosphorylation; secretion/dispersion assays Nature Communications High 24287629
2013 Wnt7a activates β-catenin/cyclin D1 pathway to stimulate neural stem cell proliferation and β-catenin/neurogenin-2 pathway to promote neuronal differentiation in the hippocampal dentate gyrus; Wnt7a-null mice show reduced neural stem cell population, increased cell cycle exit, and decreased newborn neurons with impaired dendritic development. Wnt7a knockout mouse; BrdU labeling; β-catenin reporter; immunofluorescence; neurosphere assay Molecular and Cellular Biology High 23629626
2014 Wnt7a/Fzd7 signaling increases the polarity and directional migration of satellite cells through activation of Dvl2 and the small GTPase Rac1; Wnt7a treatment improves tissue dispersal and engraftment of transplanted myogenic cells, enhancing muscle function. siRNA knockdown of Dvl2 and Rac1; directional migration assay; satellite cell transplantation into dystrophic muscle; functional muscle force measurements Journal of Cell Biology High 24711502
2014 WNT7A/β-catenin signaling directly regulates FGF1 expression via TCF binding elements in the FGF1-1C promoter; chromatin immunoprecipitation (ChIP) demonstrates β-catenin binding to this locus; FGF1 is sufficient to drive WNT7A tumor-promoting effects in ovarian cancer. ChIP assay; TCF-binding site mutation in FGF1 promoter reporter; FGF1 knockdown in WNT7A-overexpressing cells; xenograft mouse model Oncogene High 25174399
2014 WNT7A controls corneal epithelium differentiation through PAX6; loss of WNT7A or PAX6 redirects limbal stem cells toward a skin-like epithelial fate; WNT7A acts upstream of PAX6 in determining corneal epithelial cell fate. In vitro LSC expansion and 3D corneal differentiation; WNT7A and PAX6 loss-of-function; PAX6 transduction into skin epithelial stem cells; rabbit corneal transplantation model Nature High 25030175
2015 Wnt7a induces cellular senescence independently of β-catenin and independently of the classical p16(INK4a)/p19(ARF) oncogene-induced senescence pathway; mechanistically, Wnt7a induces senescence via inactivation of SKP2 (S-phase kinase-associated protein 2); Wnt7a-null mice exhibit increased lung tumorigenesis with reduced senescence markers. Wnt7a-null mouse model (two strains); senescence marker analysis; SKP2 expression assays; carcinogen-induced tumorigenesis model Oncogene Medium 25728679
2016 Wnt7a secreted by aggressive breast tumor cells induces cancer-associated fibroblast (CAF) conversion and promotes ECM remodeling and metastasis; mechanistically, Wnt7a-mediated fibroblast activation potentiates TGFβ receptor signaling independently of classical Wnt signaling. In vivo mouse tumor models; 3D in vitro co-culture; TGFβ signaling assays; Wnt7a-specific inhibition Nature Communications Medium 26777421
2017 Reck and Gpr124 are required co-receptors for Wnt7a/Wnt7b-specific signaling in CNS vascular endothelial cells; the N-terminal domain of Reck binds the LRR and Ig domains of Gpr124; soluble probes confirm that Reck and Gpr124 are part of a cell-surface complex with Frizzled, Wnt7a/Wnt7b; targeted mutagenesis of the Reck-Gpr124 interaction reduces Wnt7a signaling and impairs CNS angiogenesis. Vascular EC-specific Reck knockout; targeted mutagenesis of Reck-Gpr124 interaction; soluble probe binding assays; cell culture Wnt7a signaling assays; in vivo CNS angiogenesis analysis Neuron High 28803732
2018 Wnt7a and Norrin/Fz4 systems show threshold effects and partial redundancy in maintaining the blood-brain barrier (BBB) and blood-retina barrier; combined loss of Wnt7a and Norrin, or Wnt7a and Fz4, produces far more severe BBB defects than individual losses; glia are the source of Wnt7a in the cerebellum for BBB maintenance. Conditional knockout mouse models (cell-type-specific); combinatorial genetic analysis; BBB permeability assays PNAS High 30478038
2019 Two clusters of amino acids in Wnt7a (one at the N-terminus, one in a protruding loop) that distinguish Wnt7a/7b from other Wnts are essential for Reck/Gpr124-dependent signaling; within Reck, the fourth CC domain (CC4), specifically residues P256 and W261, is essential for Wnt7a stimulation without altering protein abundance or surface localization. Site-directed mutagenesis of Wnt7a and Reck; cell culture Wnt7a signaling assays; mouse embryo analysis of Reck CC4 mutants eLife High 31225798
2019 Wnt7a promotes VEGF signaling in pulmonary microvascular endothelial cells by facilitating Y1175 tyrosine phosphorylation in VEGFR2 through the Wnt-specific receptor ROR2; ROR2 knockdown mimics Wnt7a insufficiency and prevents recovery of tip cell formation. Recombinant Wnt7a treatment of PMVECs; ROR2 siRNA knockdown; VEGFR2 Y1175 phosphorylation assay; filopodia/tip cell formation assay; Wnt7a-/- mouse European Respiratory Journal Medium 37024132
2020 WNT7A inhibits adipogenesis of fibro-adipogenic progenitors (FAPs) by inducing nuclear localization of YAP through Rho GTPase in a β-catenin-independent manner and by promoting nuclear retention of YAP and TAZ in differentiating FAPs; intramuscular WNT7A injection in vivo suppresses fatty infiltration. FAP cell culture; YAP/TAZ localization by immunofluorescence; Rho inhibition; β-catenin knockdown; in vivo intramuscular injection; glycerol injury model Stem Cell Reports Medium 37001514
2022 In zebrafish, Gpr124 facilitates delivery of Reck-bound Wnt7a/b to Frizzled via intracellular scaffolding mechanisms: an internal Dvl-binding motif and a C-terminal ETTV motif recruiting Dlg4 and Magi3 mediate Gpr124-Frizzled interactions; mammalian Gpr124 uses an ICD-independent mechanism involving transmembrane and extracellular domains instead. Zebrafish genetic and molecular analysis; domain deletion and mutagenesis; co-immunoprecipitation of Dvl, Dlg4, Magi3; comparison of zebrafish vs. mouse/human Gpr124 Cell Reports Medium 35649360
2007 Wnt-7a induces dissociation of the APC protein from the β-catenin cytoplasmic complex, promotes APC relocalization to membranes and clustering in neurites, and induces co-clustering of APC with α7-nicotinic acetylcholine receptors (α7-nAChRs) at presynaptic terminals in hippocampal neurons; APC serves as an intermediary for α7-nAChR presynaptic relocalization. Hippocampal neuron treatment with Wnt-7a; co-immunoprecipitation; immunofluorescence colocalization; receptor clustering assays Journal of Neuroscience Medium 17507554
2023 Basal cell-derived WNT7A activates fibroblasts at the fibrotic niche in idiopathic pulmonary fibrosis; WNT7A inhibits AEC2 progenitor cell renewal in 3D organoid cultures; neutralizing antibodies against WNT7A or Frizzled signaling inhibitors abolish basal cell-induced fibroblast activation and attenuate lung fibrosis in a repetitive bleomycin mouse model. 3D organoid cultures; conditioned medium experiments; neutralizing antibodies; small molecule Frizzled inhibitor; repetitive bleomycin in vivo model; single-cell RNA sequencing American Journal of Respiratory Cell and Molecular Biology Medium 36318668
2018 Wnt-7a stimulates dendritic spine morphogenesis in hippocampal neurons via GSK-3β inhibition, triggering β-catenin/TCF/LEF-dependent transcription and promoting PSD-95 expression; β-catenin/TCF/LEF inhibitor treatment of wild-type mice reduces spatial memory, spine density, and PSD-95 levels. Wnt-7a protein treatment of hippocampal neurons; GSK-3β and β-catenin inhibitors; Golgi staining of spine density; spatial memory behavioral testing in mice Molecular Neurobiology Medium 29967987
2024 SARS-CoV-2 infection suppresses Wnt/β-catenin signaling in brain endothelial cells; delivery of engineered cerebrovascular-targeted Wnt7a ligands protects BBB integrity, reduces T-cell brain infiltration, reduces microglial activation, and mitigates cognitive deficits in a mouse COVID-19 model. Transcriptional analysis of brain endothelial cells in vivo; engineered Wnt7a ligand delivery; BBB permeability assay; T-cell infiltration quantification; behavioral assays (novel object recognition, pole descent) Brain Medium 38306655

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1995 Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature 597 7885472
2000 Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling. Cell 579 10721990
2009 Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell stem cell 397 19497282
1995 Induction of the LIM homeobox gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb. Cell 389 7585966
1998 Wnt-7a maintains appropriate uterine patterning during the development of the mouse female reproductive tract. Development (Cambridge, England) 293 9671592
2013 Fibronectin regulates Wnt7a signaling and satellite cell expansion. Cell stem cell 291 23290138
1995 Interaction between the signaling molecules WNT7a and SHH during vertebrate limb development: dorsal signals regulate anteroposterior patterning. Cell 274 7697724
1998 Sexually dimorphic development of the mammalian reproductive tract requires Wnt-7a. Nature 261 9790192
1998 Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium. Journal of cell science 260 9570753
1997 WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons. Developmental biology 238 9405095
2014 WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis. Nature 201 25030175
2011 Wnt7a-Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle. Nature cell biology 194 22179044
1993 Wnt-5a and Wnt-7a are expressed in the developing chick limb bud in a manner suggesting roles in pattern formation along the proximodistal and dorsoventral axes. Mechanisms of development 183 8297789
2011 Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²⁺/Calmodulin-dependent protein kinase II. Proceedings of the National Academy of Sciences of the United States of America 179 21670302
2000 Altered HOX and WNT7A expression in human lung cancer. Proceedings of the National Academy of Sciences of the United States of America 179 11070089
2017 Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation. Neuron 161 28803732
2003 WNT7a induces E-cadherin in lung cancer cells. Proceedings of the National Academy of Sciences of the United States of America 156 12937339
2011 Postnatal deletion of Wnt7a inhibits uterine gland morphogenesis and compromises adult fertility in mice. Biology of reproduction 147 21508348
2012 WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway. Molecular cancer research : MCR 146 22232518
2005 Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation. The Journal of biological chemistry 135 15705594
1997 Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development (Cambridge, England) 135 9362463
2018 Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance. Proceedings of the National Academy of Sciences of the United States of America 133 30478038
2016 Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness. Nature communications 131 26777421
2014 Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength. The Journal of cell biology 130 24711502
2013 Wnt7a regulates multiple steps of neurogenesis. Molecular and cellular biology 128 23629626
2008 Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells. Molecular cancer research : MCR 124 18567805
2003 Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. The Journal of biological chemistry 120 12857724
2006 Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome. American journal of human genetics 118 16826533
2010 Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis. Development (Cambridge, England) 102 20530549
2007 Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 100 17507554
2006 Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma. The Journal of biological chemistry 99 16835228
2004 Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms. The Journal of biological chemistry 95 15082716
2018 Wnt7a activates canonical Wnt signaling, promotes bladder cancer cell invasion, and is suppressed by miR-370-3p. The Journal of biological chemistry 94 29549123
2012 Wnt7a treatment ameliorates muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America 94 23185011
2010 Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer. Molecular cancer research : MCR 83 20501643
2005 Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing. The Journal of biological chemistry 82 15802269
1999 Wnt-7a in feather morphogenesis: involvement of anterior-posterior asymmetry and proximal-distal elongation demonstrated with an in vitro reconstitution model. Development (Cambridge, England) 81 10331970
2014 WNT7A/β-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer. Oncogene 79 25174399
2002 Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B in human cancer. International journal of oncology 75 12239632
1999 Successive formative stages of precartilaginous mesenchymal condensations in vitro: modulation of cell adhesion by Wnt-7A and BMP-2. Journal of cellular physiology 71 10430171
2006 BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway. Molecules and cells 69 17202865
2004 En1 and Wnt7a interact with Dkk1 during limb development in the mouse. Developmental biology 57 15242796
2012 c-Met and NF-κB-dependent overexpression of Wnt7a and -7b and Pax2 promotes cystogenesis in polycystic kidney disease. Journal of the American Society of Nephrology : JASN 55 22677559
2002 Interactions between dorsal-ventral patterning genes lmx1b, engrailed-1 and wnt-7a in the vertebrate limb. The International journal of developmental biology 55 12455631
2006 PCBs exert an estrogenic effect through repression of the Wnt7a signaling pathway in the female reproductive tract. Environmental health perspectives 54 16759992
2016 Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin. Nature communications 53 26838601
2004 Wnt7a is a suppressor of cell death in the female reproductive tract and is required for postnatal and estrogen-mediated growth. Biology of reproduction 48 15070830
2002 AP-1 transcription factor complex is a target of signals from both WnT-7a and N-cadherin-dependent cell-cell adhesion complex during the regulation of limb mesenchymal chondrogenesis. Experimental cell research 48 11822875
2019 Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development. eLife 46 31225798
2017 A Conditioned Medium of Umbilical Cord Mesenchymal Stem Cells Overexpressing Wnt7a Promotes Wound Repair and Regeneration of Hair Follicles in Mice. Stem cells international 44 28337222
2015 Wnt7a is a novel inducer of β-catenin-independent tumor-suppressive cellular senescence in lung cancer. Oncogene 43 25728679
2012 Methylation of Wnt7a is modulated by DNMT1 and cigarette smoke condensate in non-small cell lung cancer. PloS one 43 22403725
1998 The classical mouse mutant postaxial hemimelia results from a mutation in the Wnt 7a gene. Developmental biology 42 9769174
2013 A truncated Wnt7a retains full biological activity in skeletal muscle. Nature communications 41 24287629
2014 Supplementation of ketoacids contributes to the up-regulation of the Wnt7a/Akt/p70S6K pathway and the down-regulation of apoptotic and ubiquitin-proteasome systems in the muscle of 5/6 nephrectomised rats. The British journal of nutrition 38 24502851
2007 Characterization of WNT7A expression in human endometrium and endometriotic lesions. Fertility and sterility 38 17588571
2019 Co-delivery of Wnt7a and muscle stem cells using synthetic bioadhesive hydrogel enhances murine muscle regeneration and cell migration during engraftment. Acta biomaterialia 37 31228633
2016 WNT7A Regulation by miR-15b in Ovarian Cancer. PloS one 36 27195958
1994 Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a. Genomics 35 7896292
2023 Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling. Acta pharmacologica Sinica 34 37344564
2022 An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates. Cell reports 33 35649360
2020 WNT7A Promotes EGF-Induced Migration of Oral Squamous Cell Carcinoma Cells by Activating β-Catenin/MMP9-Mediated Signaling. Frontiers in pharmacology 33 32174831
2020 circRNA_001275 upregulates Wnt7a expression by competitively sponging miR‑370‑3p to promote cisplatin resistance in esophageal cancer. International journal of oncology 33 32319613
2000 Involvement of frizzled-10 in Wnt-7a signaling during chick limb development. Development, growth & differentiation 33 11142678
2015 Expression of WNT genes in cervical cancer-derived cells: Implication of WNT7A in cell proliferation and migration. Experimental cell research 32 25978974
2012 Alterations of the WNT7A gene in clear cell renal cell carcinomas. PloS one 32 23056560
2003 Wnt11 and Wnt7a are up-regulated in association with differentiation of cardiac conduction cells in vitro and in vivo. Developmental dynamics : an official publication of the American Association of Anatomists 32 12889062
2012 Wnt7A identifies embryonic γ-motor neurons and reveals early postnatal dependence of γ-motor neurons on a muscle spindle-derived signal. The Journal of neuroscience : the official journal of the Society for Neuroscience 31 22723712
2012 Symmetric expansion of neural stem cells from the adult olfactory bulb is driven by astrocytes via WNT7A. Stem cells (Dayton, Ohio) 31 22987443
1996 Isolation, characterization and chromosomal assignment of the human WNT7A gene. Cytogenetics and cell genetics 31 8893824
2023 Cadmium aggravates the blood-brain barrier disruption via inhibition of the Wnt7A/β-catenin signaling axis. Environmental pollution (Barking, Essex : 1987) 30 36878275
2018 Wnt7a promotes wound healing by regulation of angiogenesis and inflammation: Issues on diabetes and obesity. Journal of dermatological science 30 29853224
2018 Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling. Molecular neurobiology 30 29967987
2019 Roles of Wnt7a in embryo development, tissue homeostasis, and human diseases. Journal of cellular biochemistry 29 31271226
2017 The Wnt/β-catenin signaling in endometriosis, the expression of total and active forms of β-catenin, total and inactive forms of glycogen synthase kinase-3β, WNT7a and DICKKOPF-1. European journal of obstetrics, gynecology, and reproductive biology 29 29107840
2020 Three-dimensional niche stiffness synergizes with Wnt7a to modulate the extent of satellite cell symmetric self-renewal divisions. Molecular biology of the cell 28 32491970
2023 Basal Cell-derived WNT7A Promotes Fibrogenesis at the Fibrotic Niche in Idiopathic Pulmonary Fibrosis. American journal of respiratory cell and molecular biology 27 36318668
2023 WNT7A suppresses adipogenesis of skeletal muscle mesenchymal stem cells and fatty infiltration through the alternative Wnt-Rho-YAP/TAZ signaling axis. Stem cell reports 27 37001514
2011 A novel homozygous missense mutation (c.610G>A, p.Gly204Ser) in the WNT7A gene causes tetra-amelia in two Saudi families. American journal of medical genetics. Part A 27 21344627
2008 Wnt7a interaction with Fzd5 and detection of signaling activation using a split eGFP. Biochemical and biophysical research communications 27 18230341
2024 Engineered Wnt7a ligands rescue blood-brain barrier and cognitive deficits in a COVID-19 mouse model. Brain : a journal of neurology 26 38306655
2003 WNT7A mutations in patients with Müllerian duct abnormalities. Journal of pediatric and adolescent gynecology 26 14550385
2020 Involvement of Wnt7a in the role of M2c microglia in neural stem cell oligodendrogenesis. Journal of neuroinflammation 25 32192522
2014 Diverse roles for Wnt7a in ventral midbrain neurogenesis and dopaminergic axon morphogenesis. Stem cells and development 25 24803261
2012 Dynamic regulation of Wnt7a expression in the primate endometrium: implications for postmenstrual regeneration and secretory transformation. Endocrinology 25 22294752
2016 Endosulfan affects uterine development and functional differentiation by disrupting Wnt7a and β-catenin expression in rats. Molecular and cellular endocrinology 24 26911934
2010 A novel homozygous Arg222Trp missense mutation in WNT7A in two sisters with severe Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome. American journal of medical genetics. Part A 23 20949531
2005 Genetic interaction between Wnt7a and Lrp6 during patterning of dorsal and posterior structures of the mouse limb. Developmental dynamics : an official publication of the American Association of Anatomists 23 15880584
2001 Decreased expression of Wnt7a mRNA is inversely associated with the expression of estrogen receptor-alpha in human uterine leiomyoma. The Journal of clinical endocrinology and metabolism 23 11232041
1997 Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25. Gene 23 9161407
2020 Wnt7a Counteracts Cancer Cachexia. Molecular therapy oncolytics 22 32055677
2017 Wnt7a induces a unique phenotype of monocyte-derived macrophages with lower phagocytic capacity and differential expression of pro- and anti-inflammatory cytokines. Immunology 21 28872671
2022 Exosomal Wnt7a from a low metastatic subclone promotes lung metastasis of a highly metastatic subclone in the murine 4t1 breast cancer. Breast cancer research : BCR 20 36096830
2021 Wnt7a promotes the osteogenic differentiation of human mesenchymal stem cells. International journal of molecular medicine 20 33846764
2018 Effects of sex on response of the bovine preimplantation embryo to insulin-like growth factor 1, activin A, and WNT7A. BMC developmental biology 20 30055575
2023 Wnt7a deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension. The European respiratory journal 19 37024132
2018 The effects of letrozole and clomiphene citrate on ligands expression of Wnt3, Wnt7a, and Wnt8b in proliferative endometrium of women with Polycystic ovarian syndrome. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 19 29510649
2012 Peripheral T-lymphocytes express WNT7A and its restoration in leukemia-derived lymphoblasts inhibits cell proliferation. BMC cancer 19 22313908
2007 Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumours. Clinical endocrinology 19 17201809
2013 Lmx-1b and Wnt-7a expression in axolotl limb during development and regeneration. Okajimas folia anatomica Japonica 18 23614984

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