Affinage

FZD9

Frizzled-9 · UniProt O00144

Length
591 aa
Mass
64.5 kDa
Annotated
2026-06-09
91 papers in source corpus 17 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FZD9 is a seven-transmembrane Frizzled Wnt receptor that signals predominantly through non-canonical, β-catenin-independent pathways to control tissue differentiation, bone formation, neuronal connectivity, and tumor suppression (PMID:15705594, PMID:21402791, PMID:27402827). It binds Wnt-7a directly and activates JNK rather than β-catenin/TCF signaling, inducing cadherin and Sprouty-4 expression and promoting epithelial differentiation while suppressing anchorage-independent growth in lung cells (PMID:15705594); this Wnt-7a/FZD9 axis activates the Sprouty-4 promoter through PPARγ, and a reciprocal regulatory loop exists in which PPARγ also transcriptionally activates FZD9 in lung epithelium (PMID:20501643, PMID:35924166). In neurons, FZD9 localizes to postsynaptic regions, binds Wnt-5a, and forms a precoupled complex with Gαo that dissociates upon Wnt-5a stimulation, with Gαo driving spine density increases and Gβγ mediating cytosolic calcium elevation and spinogenesis (PMID:27402827). FZD9 is required for normal bone formation, where in osteoblasts it acts independently of canonical Wnt to regulate matrix mineralization, chemokine and interferon-regulated gene expression (including Isg15), and fracture healing (PMID:21402791, PMID:24391920), and under mechanical stress it drives Akt/ERK phosphorylation, actin remodeling, and YAP nuclear translocation (PMID:37585277). FZD9 is also required for pre-B cell development (PMID:15572594), marks a restricted subset of cochlear hair cell progenitors (PMID:31427926), and acts as an essential effector downstream of Myc in pancreatic islet tumorigenesis (PMID:33653688). In lung carcinogenesis FZD9 functions as a tumor-suppressive receptor whose expression is post-transcriptionally repressed by miR-31 and by miR-520a-5p binding to its 3'UTR, and whose signaling is essential for the chemopreventive action of the prostacyclin analogue iloprost (PMID:35707728, PMID:27339092, PMID:35149732). Deletion of FZD9 increases neural progenitor doubling time and apoptosis, identifying it as a contributory gene in the Williams syndrome deletion interval (PMID:27509850).

Mechanistic history

Synthesis pass · year-by-year structured walk · 16 steps
  1. 1999 Medium

    Establishing that FZD9 is a bona fide membrane Wnt receptor with a broad developmental expression pattern set the stage for assigning it tissue-specific signaling roles.

    Evidence cDNA cloning, immunohistochemistry of transfected cells, and RNA in situ hybridization in mouse

    PMID:10198163

    Open questions at the time
    • No ligand or downstream pathway identified at this stage
    • Localization shown only in overexpression context
  2. 2004 High

    A knockout established the first in vivo physiological requirement for FZD9, in pre-B cell development, showing the receptor is non-redundant in hematopoiesis.

    Evidence Fzd9-/- mice with competitive bone marrow reconstitution and flow cytometry

    PMID:15572594

    Open questions at the time
    • Ligand and signaling pathway in B-cell development not defined
    • Cell-intrinsic defect only partial
  3. 2005 High

    Identifying Wnt-7a as a direct FZD9 ligand that activates JNK rather than β-catenin defined FZD9 as a non-canonical receptor with tumor-suppressive output in lung epithelium.

    Evidence Co-IP, soft agar and 3D culture assays, JNK gain-of-function, and gene expression analysis in NSCLC cells

    PMID:15705594

    Open questions at the time
    • Coupling mechanism to JNK not resolved
    • Whether other Wnts engage FZD9 in this context unknown
  4. 2008 Medium

    A report of WNT2 binding and β-catenin/DVL/AXIN co-localization raised the possibility of FZD9 also driving canonical signaling, contrasting with the non-canonical model.

    Evidence Reciprocal co-IP and immunofluorescence co-localization in human cumulus cells

    PMID:19038973

    Open questions at the time
    • No functional validation beyond co-localization
    • Canonical pathway inference correlative
    • Not reconciled with non-canonical findings in other tissues
  5. 2010 Medium

    Placing PPARγ between Wnt-7a/FZD9 and Sprouty-4 transcription provided a defined molecular intermediary for the receptor's anti-transformation program.

    Evidence Promoter-reporter assays, stable transfection, and siRNA knockdown in NSCLC cells

    PMID:20501643

    Open questions at the time
    • Mechanism linking FZD9 to PPARγ activation not defined
    • Single cell-type context
  6. 2011 High

    Knockout analysis defined FZD9 as a non-canonical driver of osteoblast function and bone formation, with chemokine and interferon-regulated genes including Isg15 as candidate effectors.

    Evidence Fzd9-/- mice, primary osteoblast mineralization assays, expression profiling, and β-catenin pathway exclusion

    PMID:21402791

    Open questions at the time
    • Ligand and proximal signaling in osteoblasts unidentified
    • Isg15 role causal vs correlative not established
  7. 2013 High

    Extending the bone phenotype to fracture repair confirmed FZD9 is required for new bone formation in regenerative contexts via non-canonical Wnt signaling.

    Evidence Fzd9-/- femur osteotomy model with micro-CT, histomorphometry, and biomechanical testing

    PMID:24391920

    Open questions at the time
    • Chemokine reductions (Ccl2, Cxcl5) not mechanistically tied to phenotype
    • Proximal signaling unresolved
  8. 2014 Medium

    Demonstrating FZD9 antagonizes agrin-induced AChR clustering revealed a role at the neuromuscular junction linked to cytosolic β-catenin accumulation.

    Evidence Gain- and loss-of-function in myotubes, AChR clustering assays, and embryonic NMJ immunolocalization

    PMID:24860427

    Open questions at the time
    • Ligand driving NMJ effect not identified
    • Single lab, mechanism of β-catenin accumulation unclear
  9. 2016 High

    Resolving FZD9 coupling to a precoupled Gαo complex that dissociates on Wnt-5a binding, with Gαo and Gβγ controlling spine density and calcium, provided the receptor's clearest G-protein signaling mechanism.

    Evidence Co-IP of FZD9-Gαo, FZD9 knockdown, G-protein inhibitors, and calcium imaging in hippocampal neurons

    PMID:27402827

    Open questions at the time
    • Structural basis of Gαo precoupling not defined
    • Downstream effectors of calcium in spinogenesis incompletely mapped
  10. 2016 High

    Mapping the Williams syndrome neural progenitor phenotype to FZD9 via an atypical deletion established a contributory developmental role in human neurogenesis.

    Evidence Patient iPSC-derived neural progenitors, atypical deletion mapping, proliferation and apoptosis assays

    PMID:27509850

    Open questions at the time
    • Signaling pathway mediating progenitor defect not identified
    • Contribution relative to other deletion-interval genes in full syndrome unresolved
  11. 2016 Medium

    Identifying miR-31 as a repressor of FZD9 connected tobacco carcinogen exposure and prostacyclin chemoprevention to receptor abundance.

    Evidence Mouse models and in vitro carcinogen treatment with miR-31 and FZD9 expression analysis

    PMID:27339092

    Open questions at the time
    • No direct 3'UTR binding assay reported
    • Single lab
  12. 2019 Medium

    Lineage tracing established Fzd9 as a marker of a restricted subset of cochlear supporting cells that act as hair cell progenitors.

    Evidence Fzd9-CreER lineage tracing, sphere-forming, sorting, and hair cell differentiation assays

    PMID:31427926

    Open questions at the time
    • Functional requirement for FZD9 (vs marker status) not tested
    • Signaling role in progenitor function undefined
  13. 2021 High

    Genetic epistasis placed FZD9 as an essential Wnt-pathway effector downstream of Myc required for sustained pancreatic islet tumor expansion and β-cell dedifferentiation.

    Evidence Fzd9 KO in Myc-driven insulinoma mice, pharmacological Wnt inhibition, and expression analysis

    PMID:33653688

    Open questions at the time
    • Ligand driving the oncogenic FZD9 signal not identified
    • Branch of Wnt signaling operative in this context unresolved
  14. 2022 High

    In vivo and in vitro studies established a reciprocal FZD9-PPARγ relationship and confirmed FZD9 as the essential receptor for iloprost lung cancer chemoprevention.

    Evidence Fzd9-/- urethane lung adenoma model with iloprost, bronchial epithelial knockdown, PPARγ reporter and EMT/invasion assays

    PMID:35707728 PMID:35924166

    Open questions at the time
    • Direct molecular link between FZD9 and PPARγ activation not defined
    • Smoke-induced FZD9 downregulation mechanism only partly explained
  15. 2022 Medium

    A 3'UTR reporter assay identified miR-520a-5p as a direct post-transcriptional repressor of FZD9, with iloprost rescuing its pro-tumor effects.

    Evidence 3'UTR luciferase reporter, miR-520a-5p mimic/inhibitor, and iloprost rescue in lung cell lines

    PMID:35149732

    Open questions at the time
    • Relative contribution of miR-520a-5p versus miR-31 not weighted
    • Single lab
  16. 2023 Medium

    Under simulated microgravity FZD9 was shown to drive osteogenic mechanotransduction via Akt/ERK phosphorylation, actin remodeling, and YAP nuclear translocation independent of β-catenin.

    Evidence Fzd9 overexpression under rotating culture with Western blot, F-actin staining, and YAP localization imaging

    PMID:37585277

    Open questions at the time
    • Overexpression-based; endogenous requirement not tested
    • Connection between FZD9 and YAP activation not mechanistically resolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a single receptor selects among JNK, Gαo/Gβγ, PPARγ, and YAP outputs in different tissues, and which Wnt ligand drives each context, remains unresolved.
  • No structural basis for ligand- or tissue-specific coupling
  • Apparent canonical (β-catenin) versus non-canonical roles not reconciled
  • Proximal effectors in B cells, cochlea, and islet tumors unidentified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 2 GO:0098772 molecular function regulator activity 1
Localization
GO:0005886 plasma membrane 3
Pathway
R-HSA-1266738 Developmental Biology 3 R-HSA-1643685 Disease 3 R-HSA-162582 Signal Transduction 2
Partners
AXINCTNNB1DVLGNAO1WNT2WNT5AWNT7A

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2005 Wnt-7a and Frizzled-9 (Fzd9) interact directly (Wnt-7a detected in Fzd9 immunoprecipitates), and together they activate the JNK pathway (not β-catenin/TCF), inducing cadherin and Sprouty-4 expression, inhibiting anchorage-independent growth, and promoting epithelial differentiation in NSCLC cells. Co-immunoprecipitation, soft agar assay, 3D culture, JNK gain-of-function transfection, gene expression analysis The Journal of biological chemistry High 15705594
1999 FZD9 protein localizes to the plasma membrane when expressed in transfected cells, consistent with its function as a transmembrane Wnt receptor; the mouse homolog Fzd9 encodes a 592-aa protein with 95% identity to human FZD9 and is expressed in neural tube, myotomes, limb skeletal anlagen, craniofacial regions, nephric ducts, heart, brain, testis, and skeletal muscle. Immunohistochemistry of transfected cells, RNA in situ hybridization, cDNA cloning and sequence analysis Genomics Medium 10198163
2004 Fzd9 is required for normal B-cell development; Fzd9−/− mice display depletion of pre-B cells in bone marrow (particularly at the stage of immunoglobulin heavy chain expression and clonal expansion), with the pre-B defect being partially cell-intrinsic as shown by competitive bone marrow reconstitution. Fzd9 knockout mice, competitive bone marrow reconstitution, flow cytometry Blood High 15572594
2008 WNT2 interacts with FZD9 in human cumulus cells, as demonstrated by co-immunoprecipitation (WNT2 antibody precipitated FZD9 and FZD9 antibody precipitated WNT2); FZD9 co-localizes with DVL and AXIN at the plasma membrane and with β-CATENIN, suggesting FZD9-mediated canonical Wnt signaling that recruits β-catenin to the membrane and promotes adherens junction formation. Co-immunoprecipitation, immunofluorescence co-localization Molecular human reproduction Medium 19038973
2010 Wnt-7a/Fzd9 signaling activates the Sprouty-4 (Spry4) promoter through peroxisome proliferator-activated receptor gamma (PPARγ), identifying Spry4 as a downstream transcriptional target of the Wnt7A/Fzd9 non-canonical pathway in NSCLC cells. Promoter-reporter assays, stable transfection, siRNA knockdown, gene expression analysis Molecular cancer research : MCR Medium 20501643
2011 Fzd9 is required for osteoblast function and bone formation; Fzd9−/− mice display low bone mass due to impaired bone formation (not resorption). Fzd9−/− primary osteoblasts show defects in matrix mineralization and reduced expression of chemokines and interferon-regulated genes (including Isg15 as a potential downstream mediator), without impairment of canonical Wnt/β-catenin signaling, indicating Fzd9 acts via a non-canonical pathway in osteoblasts. Fzd9 knockout mice, primary osteoblast culture, matrix mineralization assay, gene expression profiling, β-catenin pathway analysis The Journal of cell biology High 21402791
2013 Fzd9 regulates intramembranous and endochondral bone formation during fracture healing via non-canonical Wnt signaling; Fzd9−/− mice show significantly reduced new bone formation at all healing time points and decreased mechanical competence of callus, while cartilage formation and osteoclast numbers are unaffected and β-catenin localization is unchanged. Chemokines Ccl2 and Cxcl5 appear reduced in Fzd9−/− fracture callus. Fzd9−/− mice, femur osteotomy fracture model, micro-CT, histomorphometry, immunohistochemistry, biomechanical testing PloS one High 24391920
2014 FZD9-mediated signaling impairs acetylcholine receptor (AChR) clustering in skeletal muscle: overexpression of Fzd9 in myotubes reduces agrin-induced AChR clustering and induces cytosolic accumulation of β-catenin; Fzd9 and β-catenin co-localize at embryonic NMJ postsynaptic domains in vivo. Loss-of-function experiments confirm that Fzd9 antagonizes postsynaptic AChR assembly at the neuromuscular junction. Gain- and loss-of-function transfection in cultured myotubes, AChR clustering assay, immunolocalization in embryonic NMJ, β-catenin accumulation assay Frontiers in cellular neuroscience Medium 24860427
2016 FZD9 is required for Wnt-5a-induced dendritic spine formation in hippocampal neurons. FZD9 localizes to the postsynaptic region, interacts with Wnt-5a, and forms a precoupled complex with Gαo that dissociates upon Wnt-5a stimulation. Gαo activation and Gβγ are downstream mediators of FZD9 signaling: Gαo controls Wnt-5a-induced spine density increase, while Gβγ is required for cytosolic calcium elevation and spinogenesis. Co-immunoprecipitation (FZD9–Gαo complex), siRNA knockdown of FZD9, G-protein inhibition experiments, calcium imaging, dendritic spine quantification in cultured hippocampal neurons The Journal of biological chemistry High 27402827
2016 FZD9 deletion or loss is the single gene cause of increased neural progenitor cell doubling time and apoptosis observed in Williams syndrome iPSC-derived neural progenitors, narrowed by studying an individual with atypical Williams syndrome carrying a smaller deletion encompassing FZD9. iPSC-derived neural progenitor cells from Williams syndrome patients, atypical deletion mapping, cell proliferation and apoptosis assays Nature High 27509850
2021 Fzd9 is an essential effector downstream of Myc in pancreatic islet tumorigenesis: Fzd9 is a Myc transcriptional target, and its deletion impairs sustained tumor expansion and β-cell dedifferentiation in a Myc-driven insulinoma mouse model. Wnt signaling inhibition in Fzd9-competent mice recapitulates the suppression of proliferation caused by Fzd9 deficiency. Fzd9 knockout in Myc-driven insulinoma mouse model, Wnt signaling inhibitor treatment, global gene expression analysis, histology Life science alliance High 33653688
2022 FZD9 is required in vivo for iloprost (prostacyclin analogue) lung cancer chemoprevention: Fzd9−/− mice treated with inhaled iloprost in a urethane lung adenoma model are not protected from adenoma development and do not show increased activation of iloprost/PPARγ signaling pathways, establishing FZD9 as the essential receptor for iloprost chemopreventive action. Fzd9 knockout mice, urethane lung adenoma model, inhaled iloprost treatment, pathway activation assays iScience High 35707728
2022 PPARγ is a transcriptional regulator of FZD9 in lung epithelium. Loss of FZD9 in bronchial epithelial cells alters EMT markers, decreases PPARγ activity, increases transformed growth and invasive behavior, and is associated with premalignant lesion development. Cigarette smoke reduces FZD9 expression and PPARγ activation in these cells. FZD9 knockdown in human bronchial epithelial cells, Fzd9−/− mouse urethane model, PPARγ reporter assays, EMT marker analysis, soft agar and invasion assays Frontiers in oncology Medium 35924166
2016 miR-31 represses FZD9 expression in lung cells; tobacco smoke carcinogens increase miR-31 expression, which reduces Fzd9 expression, while prostacyclin (iloprost) reduces miR-31 and maintains or increases Fzd9 expression, thereby enabling FZD9-dependent anti-tumor signaling. Mouse models, in vitro carcinogen treatment, miR-31 expression analysis, FZD9 expression assays Scientific reports Medium 27339092
2022 miR-520a-5p binds the FZD9 3'UTR and represses FZD9 expression and downstream target activity; cigarette smoke condensate increases miR-520a-5p expression (reducing FZD9), while iloprost decreases miR-520a-5p. miR-520a-5p mimic cancer-promoting effects are rescued by iloprost, confirming miR-520a-5p as a post-transcriptional regulator of FZD9. 3'UTR luciferase reporter assay, miR-520a-5p mimic and inhibitor transfection, iloprost treatment, FZD9 downstream target assays in lung cell lines Scientific reports Medium 35149732
2023 Fzd9 overexpression in osteoblasts under simulated microgravity (SMG) rescues osteogenic markers (ALP, OPN, RUNX2) via a non-β-catenin mechanism: Fzd9 promotes Akt and ERK phosphorylation, induces F-actin polymerization and actin cap formation, increases nuclear pore size, and drives nuclear translocation of YAP (Yes-associated protein), thereby activating mechanotransduction signaling. Simulated microgravity rotating cell culture, Fzd9 overexpression construct, Western blot for pAkt/pERK/pGSK3β/β-catenin, F-actin staining, YAP nuclear translocation imaging FASEB journal Medium 37585277
2019 Fzd9+ cochlear supporting cells (inner phalangeal cells, inner border cells, third-row Deiters' cells) function as hair cell progenitors: lineage tracing showed Fzd9+ cells generate new hair cells in vivo and in vitro (sphere-forming and differentiation assays) at similar efficiency to Lgr5+ progenitors, identifying Fzd9 as a marker of a restricted subset of cochlear hair cell progenitors. Fzd9-CreER lineage tracing, sphere-forming assay, flow cytometry sorting, in vivo and in vitro hair cell differentiation assays Frontiers in molecular neuroscience Medium 31427926

Source papers

Stage 0 corpus · 91 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 The soft agar colony formation assay. Journal of visualized experiments : JoVE 473 25408172
2007 Novel markers for the prospective isolation of human MSC. Annals of the New York Academy of Sciences 346 17395729
2008 Aberrant DNA methylation is a dominant mechanism in MDS progression to AML. Blood 318 18832655
2000 VI. Genome structure and cognitive map of Williams syndrome. Journal of cognitive neuroscience 200 10953236
2006 Human placenta and bone marrow derived MSC cultured in serum-free, b-FGF-containing medium express cell surface frizzled-9 and SSEA-4 and give rise to multilineage differentiation. Differentiation; research in biological diversity 196 17288545
1999 Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family. Biochemical and biophysical research communications 167 10448064
1999 Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21. Biochemical and biophysical research communications 143 10544037
2016 A human neurodevelopmental model for Williams syndrome. Nature 141 27509850
2005 Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation. The Journal of biological chemistry 135 15705594
2010 Activation of NFAT signaling in podocytes causes glomerulosclerosis. Journal of the American Society of Nephrology : JASN 134 20651158
2009 A microarray-based DNA methylation study of glioblastoma multiforme. Epigenetics 132 19550145
2006 Redundant expression of canonical Wnt ligands in human breast cancer cell lines. Oncology reports 131 16465433
2008 WNT signaling in stem cell biology and regenerative medicine. Current drug targets 124 18673242
2007 Activation of Wnt/beta-catenin pathway mediates growth and survival in B-cell progenitor acute lymphoblastic leukaemia. British journal of haematology 119 17614820
2012 A review of the evidence for the canonical Wnt pathway in autism spectrum disorders. Molecular autism 106 23083465
2010 Methylation profiling with a panel of cancer related genes: association with estrogen receptor, TP53 mutation status and expression subtypes in sporadic breast cancer. Molecular oncology 105 21212030
2009 A comprehensive microarray-based DNA methylation study of 367 hematological neoplasms. PloS one 95 19750229
2011 Control of bone formation by the serpentine receptor Frizzled-9. The Journal of cell biology 92 21402791
2004 Frizzled 9 knock-out mice have abnormal B-cell development. Blood 85 15572594
2010 Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer. Molecular cancer research : MCR 83 20501643
1999 Characterization and expression pattern of the frizzled gene Fzd9, the mouse homolog of FZD9 which is deleted in Williams-Beuren syndrome. Genomics 73 10198163
2014 DNA methylation profiling in the Carolina Breast Cancer Study defines cancer subclasses differing in clinicopathologic characteristics and survival. Breast cancer research : BCR 71 25287138
2007 Prospective isolation and characterization of mesenchymal stem cells from human placenta using a frizzled-9-specific monoclonal antibody. Differentiation; research in biological diversity 70 17924962
2011 Human term placenta-derived mesenchymal stromal cells are less prone to osteogenic differentiation than bone marrow-derived mesenchymal stromal cells. Stem cells and development 68 21047215
2008 Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. Molecular human reproduction 59 19038973
2017 Involvement of c-Fos in cell proliferation, migration, and invasion in osteosarcoma cells accompanied by altered expression of Wnt2 and Fzd9. PloS one 55 28665975
2010 Prospective isolation of mesenchymal stem cells from multiple mammalian species using cross-reacting anti-human monoclonal antibodies. Stem cells and development 54 20367498
2016 Wnt-5a/Frizzled9 Receptor Signaling through the Gαo-Gβγ Complex Regulates Dendritic Spine Formation. The Journal of biological chemistry 53 27402827
2015 Anti-inflammatory activity of Wnt signaling in enteric nervous system: in vitro preliminary evidences in rat primary cultures. Journal of neuroinflammation 53 25644719
2011 Identification of human placenta-derived mesenchymal stem cells involved in re-endothelialization. Journal of cellular physiology 50 20658518
2016 DNA methylation and hormone receptor status in breast cancer. Clinical epigenetics 47 26884818
2013 The Wnt serpentine receptor Frizzled-9 regulates new bone formation in fracture healing. PloS one 46 24391920
1999 Two novel Xenopus frizzled genes expressed in developing heart and brain. Mechanisms of development 46 10446283
2019 Frizzled-9+ Supporting Cells Are Progenitors for the Generation of Hair Cells in the Postnatal Mouse Cochlea. Frontiers in molecular neuroscience 41 31427926
2006 Upregulation of frizzled 9 in astrocytomas. Neuropathology and applied neurobiology 41 17083476
2013 Genetic effects on DNA methylation and its potential relevance for obesity in Mexican Americans. PloS one 37 24058506
2005 Comparative genomics on Wnt8a and Wnt8b genes. International journal of oncology 35 15754011
2018 Endothelial cells from different anatomical origin have distinct responses during SNAIL/TGF-β2-mediated endothelial-mesenchymal transition. American journal of translational research 33 30662651
2005 Comparative genomics on ROR1 and ROR2 orthologs. Oncology reports 32 16211313
2017 FZD10-Gα13 signalling axis points to a role of FZD10 in CNS angiogenesis. Cellular signalling 30 28126591
2005 Comparative genomics on Dkk1 orthologs. International journal of oncology 29 15942669
2022 Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters. Molecular psychiatry 27 35296808
2021 Therapeutic Effects of Dietary Soybean Genistein on Triple-Negative Breast Cancer via Regulation of Epigenetic Mechanisms. Nutrients 26 34836197
2017 Inducible ATF3-NFAT axis aggravates podocyte injury. Journal of molecular medicine (Berlin, Germany) 26 29038896
2012 Dissecting the impact of Frizzled receptors in Wnt/β-catenin signaling of human mesenchymal stem cells. Biological chemistry 25 23152409
2015 Single-pulsed electromagnetic field therapy increases osteogenic differentiation through Wnt signaling pathway and sclerostin downregulation. Bioelectromagnetics 23 26364557
2019 The cell type resolved mouse transcriptome in neuron-enriched brain tissues from the hippocampus and cerebellum during prion disease. Scientific reports 22 30705335
2012 Association of cigarette smoking and CRP levels with DNA methylation in α-1 antitrypsin deficiency. Epigenetics 22 22617718
2019 A Multigene Model for Predicting Tumor Responsiveness After Preoperative Chemoradiotherapy for Rectal Cancer. International journal of radiation oncology, biology, physics 20 31419511
2013 Selective modulation of Wnt ligands and their receptors in adipose tissue by chronic hyperadiponectinemia. PloS one 18 23861788
2013 Differential survival trends of stage II colorectal cancer patients relate to promoter methylation status of PCDH10, SPARC, and UCHL1. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 17 24309322
2021 Decoding pathogenesis factors involved in the progression of ATLL or HAM/TSP after infection by HTLV-1 through a systems virology study. Virology journal 15 34446027
2018 Dysregulation of the Wnt signaling pathway in South African patients with diffuse systemic sclerosis. Clinical rheumatology 14 30238381
2016 Prostacyclin reverses the cigarette smoke-induced decrease in pulmonary Frizzled 9 expression through miR-31. Scientific reports 14 27339092
2005 Identification and characterization of rat Ror1 and Ror2 genes in silico. International journal of molecular medicine 14 15702250
2020 Asymmetric distribution of pallial-expressed genes in zebrafish (Danio rerio). The European journal of neuroscience 13 32692463
2022 Neuropsychological Genotype-Phenotype in Patients with Williams Syndrome with Atypical Deletions: A Systematic Review. Neuropsychology review 12 36520254
2019 Comparative Analysis of Biological Properties of Large-Scale Expanded Adult Neural Crest-Derived Stem Cells Isolated from Human Hair Follicle and Skin Dermis. Stem cells international 12 30915126
2016 Wnts Are Expressed in the Ependymal Region of the Adult Spinal Cord. Molecular neurobiology 12 27722925
1991 Protein kinase C-mediated contraction in rabbit aorta is inhibited by CD-349, a dihydropyridine derivative. Journal of cardiovascular pharmacology 12 1713994
2022 miR-520a-5p regulates Frizzled 9 expression and mediates effects of cigarette smoke and iloprost chemoprevention. Scientific reports 11 35149732
2014 Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells. Frontiers in cellular neuroscience 11 24860427
2016 Autophagy-related gene 5 and Wnt5 signaling pathway requires differentiation of embryonic stem cells into odontoblast-like cells. Experimental cell research 10 26806855
2016 Methylation status of the promoter region of the human frizzled 9 gene in acute myeloid leukemia. Molecular medicine reports 10 27314612
2005 Identification and characterization of rat Ankrd6 gene in silico. International journal of molecular medicine 10 15647854
1988 A new Ca-antagonist, CD-349, binding to the Ca-channel of rat myocardium and brain and hog coronary artery. Japanese journal of pharmacology 10 2854176
2021 The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets. Life science alliance 9 33653688
2012 Effects of keratinocyte growth factor on skin epithelial differentiation of human amnion epithelial cells. Burns : journal of the International Society for Burn Injuries 9 23273814
2000 Isolation of Xenopus frizzled-10A and frizzled-10B genomic clones and their expression in adult tissues and embryos. Biochemical and biophysical research communications 9 11097845
2022 Iloprost requires the Frizzled-9 receptor to prevent lung cancer. iScience 8 35707728
2012 Endogenous and induced angiogenic characteristics of human chorion-derived stem cells. Cell biology international 8 22957758
2024 Identification of potential candidate miRNAs related to semen quality in seminal plasma extracellular vesicles and sperms of male duck (Anas Platyrhynchos). Poultry science 7 39003794
2017 Large-scale expansion and characterization of human adult neural crest-derived multipotent stem cells from hair follicle for regenerative medicine applications. Experimental oncology 7 28967641
2016 Gelatin scaffold combined with bone morphogenetic protein-4 induces odontoblast-like cell differentiation involving integrin profile changes, autophagy-related gene 10, and Wnt5 sequentially in human induced pluripotent stem cells. Differentiation; research in biological diversity 7 27639333
2023 Genome-wide scan for runs of homozygosity in South American Camelids. BMC genomics 6 37605116
2014 Systemic delivery of human bone marrow embryonic-like stem cells improves motor function of severely affected dystrophin/utrophin-deficient mice. Cytotherapy 6 25442501
2021 Epigenetic Markers Are Associated With Differences in Isocyanate Biomarker Levels in Exposed Spray-Painters. Frontiers in genetics 5 34335698
2015 Polyphosphate-induced matrix metalloproteinase-3-mediated proliferation in rat dental pulp fibroblast-like cells is mediated by a Wnt5 signaling cascade. Bioscience trends 5 26166369
2010 A transgenic Cre mouse line for the study of cortical and hippocampal development. Genesis (New York, N.Y. : 2000) 5 20143346
2009 Non-association between polymorphisms of the frizzled receptor genes and bone mineral density in postmenopausal Korean women. Journal of Korean medical science 5 19543507
2023 Frizzled-9 triggers actin polymerization and activates mechano-transducer YAP to rescue simulated microgravity-induced osteoblast dysfunction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 4 37585277
2022 Loss of Frizzled 9 in Lung Cells Alters Epithelial Phenotype and Promotes Premalignant Lesion Development. Frontiers in oncology 4 35924166
2008 Upregulation of SOX-2, FZD9, Nestin, OCT-4 and FGF-4 expression in human chorion derived-stem cells after angiogenic induction. The Medical journal of Malaysia 4 19024982
1990 Interaction of the dihydropyridine calcium antagonist, CD-349, with calmodulin. Biochemical pharmacology 4 2167684
2020 A digital mRNA expression signature to classify challenging Spitzoid melanocytic neoplasms. FEBS open bio 3 32431053
2023 The Effect of Sow Maternal Behavior on the Growth of Piglets and a Genome-Wide Association Study. Animals : an open access journal from MDPI 2 38136791
2022 A paediatric dysembryoplastic neuroepithelial tumour (DNET) with deregulated stem cell markers: a case report. Translational pediatrics 2 35800288
2025 Shared pathogenic mechanisms of Parkinson's disease and ulcerative colitis: α7 nicotinic acetylcholine receptor as a potential therapeutic target. International journal of biological macromolecules 1 40609942
2026 Modeling Williams syndrome from a neurodevelopmental perspective: recent advances, model-based translational insights and future directions. World journal of pediatrics : WJP 0 41845159
2024 Development of a Low Cost Semiquantitative Polymerase Chain Reaction Assay for Molecular Diagnosis of Williams Syndrome. Clinical laboratory 0 38469782
1989 Uptake of CD-349 and nitrendipine into bovine intrapulmonary artery and vein. Journal of pharmacobio-dynamics 0 2795432

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