Affinage

FZD5

Frizzled-5 · UniProt Q13467

Length
585 aa
Mass
64.5 kDa
Annotated
2026-04-28
47 papers in source corpus 23 papers cited in narrative 23 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

FZD5 is a seven-transmembrane Wnt receptor of the class Frizzled family that transduces both canonical WNT/β-catenin and non-canonical Ca²⁺/PKC signals to regulate vascular development, stem cell self-renewal, placental morphogenesis, and neural patterning. FZD5 binds WNT ligands (WNT5A, WNT7A, WNT7B, WNT2, WNT10b) through its extracellular cysteine-rich domain and partners with LRP5/LRP6 co-receptors to stabilize β-catenin and activate TCF/LEF transcription, while also coupling to Gαq to mobilize intracellular Ca²⁺ and activate PKC and CaMKII (PMID:12857724, PMID:30514810, PMID:25861751). Surface availability of FZD5 is tightly controlled: Wnt-stimulated ZNRF3/RNF43-dependent ubiquitination drives its endocytosis and lysosomal degradation—a process antagonized by RSPO1—while CVAK104 independently mediates clathrin-dependent FZD5 internalization, and DNMT3A-mediated promoter methylation and the HIDEN lncRNA/IMP1 complex regulate its transcription and mRNA stability, respectively (PMID:41070826, PMID:19643732, PMID:38707304, PMID:37095549). Heterozygous loss-of-function mutations in FZD5 cause coloboma and microphthalmia through dominant-negative interference with WNT signaling during optic fissure closure, and FZD5 is specifically essential for Wnt-dependent proliferation of RNF43-mutant pancreatic and colorectal cancers (PMID:26908622, PMID:27869803).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2001 High

    Establishing that FZD5 is a Wnt receptor essential for embryonic vascular development resolved the question of whether Frizzled-5 has a non-redundant developmental role.

    Evidence Fzd5 knockout mice showed embryonic lethality at E10.75 from yolk sac/placental angiogenesis failure; Xenopus axis induction confirmed ligand selectivity (Wnt2, Wnt5a, Wnt10b)

    PMID:11092808

    Open questions at the time
    • Downstream intracellular signaling pathway not resolved
    • Co-receptor requirements not determined
  2. 2003 High

    Demonstration that FZD5 forms a complex with LRP6 to activate β-catenin/TCF signaling positioned FZD5 within the canonical Wnt pathway and identified its co-receptor.

    Evidence TCF-luciferase and β-catenin stability assays in PC12 cells with WNT7A, antagonized by Dkk1/Dkk3

    PMID:12857724

    Open questions at the time
    • Direct physical binding affinity between WNT7A and FZD5 not measured
    • Non-canonical signaling not addressed
  3. 2008 Medium

    Quantifying nanomolar-affinity binding of WNT7A to the FZD5 CRD established the biophysical basis for ligand-receptor selectivity.

    Evidence ELISA-based binding with purified proteins and split-eGFP complementation

    PMID:18230341

    Open questions at the time
    • Binding affinities for other WNT ligands not compared side-by-side
    • Structural basis for selectivity unknown
  4. 2009 High

    Identification of CVAK104 as a selective internalization partner for FZD5 revealed that receptor surface levels are actively regulated by clathrin-mediated endocytosis and lysosomal degradation, tuning Wnt signal strength.

    Evidence Co-IP of CVAK104 with FZD5 (not FZD1/FZD4), dominant-negative Rab5, lysosome inhibitors, siRNA

    PMID:19643732

    Open questions at the time
    • Physiological contexts where CVAK104-mediated FZD5 turnover is rate-limiting not established
    • Whether post-translational modifications gate CVAK104 binding unknown
  5. 2013 High

    Discovery of a Gcm1–FZD5 positive feedback loop in trophoblast cells explained how FZD5 drives chorionic branching morphogenesis through β-catenin-mediated junction remodeling and VEGF induction.

    Evidence Global and trophoblast-specific Fzd5/Gcm1 knockout mice, trophoblast stem cell lines, tetraploid aggregation

    PMID:23610556

    Open questions at the time
    • Whether FZD5 signals through canonical or non-canonical Wnt in trophoblasts not fully dissected
    • Ligand identity in placenta not definitively assigned
  6. 2014 Medium

    Showing that WNT5A–FZD5 triggers intracellular Ca²⁺ release, NFκB activation, and tissue factor expression in endothelial cells established a non-canonical signaling branch distinct from β-catenin.

    Evidence Paracrine co-culture, Ca²⁺ imaging, NFκB reporter, TF expression, microvessel assay

    PMID:25061751

    Open questions at the time
    • G-protein coupling not directly measured in this system
    • Contribution relative to canonical pathway not quantified
  7. 2016 High

    Two advances defined FZD5 disease relevance: a dominant-negative FZD5 truncation was shown to cause coloboma/microphthalmia, and CRISPR screening identified FZD5 as specifically essential in RNF43-mutant cancers, establishing therapeutic targeting rationale.

    Evidence Secreted truncated FZD5 (p.Ala219Glufs*49) antagonized WNT in zebrafish; genome-wide CRISPR dropout screen in PDAC plus anti-FZD5 antibody validation in organoids/xenografts

    PMID:26908622 PMID:27869803

    Open questions at the time
    • Genotype–phenotype spectrum of FZD5 mutations in humans not fully mapped
    • Mechanism of FZD5 selectivity in RNF43-mutant cancers versus other FZDs not resolved
  8. 2018 High

    Biophysical demonstration that WNT5A induces a GPCR-like conformational change in FZD5 and activates Gαq established Frizzled receptors as bona fide GPCRs, not just scaffold receptors.

    Evidence dcFRAP and BRET/FRET assays for Gαq coupling in live cells

    PMID:30514810

    Open questions at the time
    • Whether Gαq coupling occurs at endogenous FZD5 expression levels not shown
    • Structural basis for Gαq selectivity over other Gα subunits unknown
  9. 2018 Medium

    Dissection of FZD5 downstream signaling in endothelial cells and renal carcinoma showed that FZD5 restrains PKC/Ets1-driven Angpt2/Flt1 transcription and mediates WNT5A-induced PKCα/βII and CaMKII phosphorylation, expanding the non-canonical effector repertoire.

    Evidence siRNA, PKC inhibitors, Ets1 assays in endothelial cells; siRNA and phospho-western blots in renal carcinoma

    PMID:25861751 PMID:29845518

    Open questions at the time
    • Whether PKC and CaMKII are activated in parallel or sequentially downstream of FZD5 not determined
    • Direct versus indirect PKC activation not resolved
  10. 2020 Medium

    Identification of YTHDF1-mediated m6A-dependent translational enhancement of FZD5 mRNA and the WNT7B–FZD5–FOXM1 axis in cancer expanded understanding of FZD5 post-transcriptional regulation and downstream transcriptional targets.

    Evidence m6A-seq, ribosome profiling, YTHDF1 perturbation in HCC; ChIP for FOXM1 on BRCA1/BIRC5 promoters in TNBC

    PMID:33230473 PMID:33311446

    Open questions at the time
    • Whether m6A regulation of FZD5 mRNA operates in non-cancer contexts unknown
    • Direct interaction between YTHDF1 and FZD5 mRNA not shown by CLIP
  11. 2023 Medium

    Discovery that the lncRNA HIDEN scaffolds IMP1 onto FZD5 mRNA to stabilize it revealed a non-coding RNA layer of FZD5 regulation critical for endoderm differentiation, while single-cell data identified WNT7A–FZD5 as the key stem cell renewal axis in fallopian tube organoids.

    Evidence RIP, mRNA stability assay, WNT reporter rescue in hESC endoderm differentiation; scRNA-seq and functional organoid assays in fallopian tube

    PMID:37095549 PMID:37917586

    Open questions at the time
    • Structural basis of HIDEN–IMP1–FZD5 mRNA complex not defined
    • Whether FZD5 is the sole Frizzled mediating fallopian tube stemness not excluded
  12. 2024 High

    Selective upregulation of FZD5 in anterior neural progenitors and its functional sufficiency to drive dopaminergic neuron specification via a tetravalent agonist antibody clustering FZD5/LRP6 established FZD5 as a regional Wnt signal interpreter during neural patterning.

    Evidence Cell-surface FZD profiling, agonist antibody, hPSC-derived midbrain progenitor differentiation, in vivo transplantation

    PMID:38358799

    Open questions at the time
    • Endogenous ligand driving FZD5 in midbrain specification in vivo not definitively identified
    • Whether FZD5 agonist antibody activates non-canonical pathways not assessed
  13. 2025 High

    Mechanistic dissection of Wnt-induced FZD5 degradation showed ZNRF3/RNF43 selectively target FZD5/8 (not other FZDs), with RSPO1 specifically stabilizing these receptors and DVL being dispensable for ligand-induced turnover, clarifying the feedback architecture of FZD5 surface regulation.

    Evidence Endocytosis/degradation assays, co-IP of FZD5–RNF43 enhanced by Wnt, RSPO1 stabilization, DVL triple-knockout cells

    PMID:41070826

    Open questions at the time
    • Ubiquitination sites on FZD5 targeted by ZNRF3/RNF43 not mapped
    • Structural basis for FZD5/8 selectivity over other FZDs unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis for FZD5 ligand selectivity among Wnt proteins, whether Gαq coupling and β-catenin signaling are activated simultaneously or in a context-dependent manner at endogenous expression levels, and the full spectrum of human disease caused by FZD5 mutations.
  • No high-resolution structure of full-length FZD5 in complex with Wnt and co-receptor
  • Gαq versus β-catenin pathway selection logic not defined
  • Comprehensive human genetic studies beyond coloboma lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 4 GO:0098772 molecular function regulator activity 3
Localization
GO:0005886 plasma membrane 4 GO:0005764 lysosome 2 GO:0005576 extracellular region 1
Pathway
R-HSA-162582 Signal Transduction 7 R-HSA-1266738 Developmental Biology 3 R-HSA-1643685 Disease 3 R-HSA-9609507 Protein localization 2
Partners
CVAK104DVLGNA11IGF2BP1LRP5LRP6RNF43ZNRF3
Complex memberships
FZD5-LRP5 Wnt receptor complexFZD5-LRP6 Wnt receptor complex

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 Fzd5 knockout mice die in utero around E10.75 due to defects in yolk sac and placental angiogenesis, with markedly reduced endothelial cell proliferation (BrdU labeling); Fzd5 specifically synergized with Wnt2, Wnt5a, and Wnt10b in ectopic axis induction assays in Xenopus embryos, establishing Fzd5 as a Wnt receptor required for vascular development. Homologous recombination knockout mice, BrdU proliferation assay, Xenopus axis induction assay Development (Cambridge, England) High 11092808
2003 WNT7A signals through a FZD5·LRP6 receptor complex in PC12 cells to increase β-catenin stability and activate TCF-based transcription; this activity is antagonized by Dickkopf-1 and Dickkopf-3. TCF-luciferase reporter assay, β-catenin stability assay, functional epistasis with Dickkopf proteins in PC12 cells The Journal of biological chemistry High 12857724
2008 Purified Wnt7a binds to the extracellular cysteine-rich domain (CRD) of Fzd5 with nanomolar affinity, as shown by ELISA-based protein-protein binding assay; a split-eGFP complementation assay confirmed Wnt7a–Fzd5 interaction and subsequent canonical pathway activation in cells. ELISA-based binding assay, split-eGFP complementation assay Biochemical and biophysical research communications Medium 18230341
2009 CVAK104 is a novel binding partner of both Dishevelled (Dvl) and FZD5 (but not FZD1 or FZD4); CVAK104 selectively induces clathrin-mediated internalization of FZD5 and its subsequent lysosomal degradation, thereby suppressing Wnt/β-catenin signaling; knockdown of CVAK104 increases FZD5 protein levels and activates Wnt signaling. Co-immunoprecipitation, dominant-negative Rab5, siRNA knockdown, lysosome inhibitor assay, β-catenin reporter assay The Journal of biological chemistry High 19643732
2013 A positive feedback loop between Gcm1 and Fzd5 is essential for chorionic branching morphogenesis: Gcm1 upregulates Fzd5 at branching initiation sites, and elevated Fzd5 via nuclear β-catenin signaling maintains Gcm1 expression; Fzd5-mediated signaling also induces disassembly of cell junctions (downregulation of ZO-1, claudin 4, claudin 7) and upregulates Vegf in trophoblast cells. Global and trophoblast-specific Fzd5/Gcm1 knockout mice, trophoblast stem cell lines, tetraploid aggregation assay PLoS biology High 23610556
2014 Monocyte-secreted Wnt5a activates FZD5 in microvascular endothelial cells (mECs) through non-canonical signaling: FZD5 activation triggers intracellular Ca2+ release, NFκB transcriptional activity, and tissue factor (TF) gene expression, leading to angiogenesis via autocrine TF regulation. In vitro co-culture paracrine assay, intracellular Ca2+ measurement, NFκB reporter, TF expression, in vivo microvessel formation Journal of molecular cell biology Medium 25240054
2016 A heterozygous frameshift mutation in FZD5 (p.Ala219Glufs*49) produces a truncated protein that retains the WNT-ligand-binding CRD but lacks the transmembrane domain; the truncated protein is secreted from cells and acts as a dominant-negative receptor, antagonizing both canonical and non-canonical WNT signaling and causing coloboma and microphthalmia in zebrafish. Cell secretion assay, WNT signaling reporter assays, zebrafish injection, mouse retinal epithelium analysis Human molecular genetics High 26908622
2016 Genome-wide CRISPR-Cas9 screens in RNF43-mutant pancreatic ductal adenocarcinoma (PDAC) cells identify a specific requirement for FZD5 (not other Frizzled receptors) for Wnt-dependent proliferation; anti-FZD5 antibodies inhibit RNF43-mutant PDAC and colorectal cancer organoid growth in vitro and in vivo, confirming FZD5 receptor-level specificity. Genome-wide CRISPR-Cas9 dropout screen, recombinant antibodies, xenograft, patient-derived organoids Nature medicine High 27869803
2018 FZD5 functions as a prototypical GPCR: WNT-5A stimulation induces a conformational change in FZD5 reminiscent of class A/B GPCR activation, and FZD5 activates Gαq and its downstream effectors, as measured by live-cell dcFRAP and resonance energy transfer (RET)-based assays. Dual-color FRAP (dcFRAP), BRET/FRET resonance energy transfer assays, Gαq activation assays Science signaling High 30514810
2018 Surface plasmon resonance analysis demonstrates that WNT5A binds FZD5 with ~30% stronger response than to RYK; FZD5 knockdown completely abrogates the anti-proliferative effect of WNT5A in PC3 prostate cancer cells, whereas RYK knockdown preferentially mediates the pro-apoptotic effect. Surface plasmon resonance, siRNA knockdown, proliferation and apoptosis assays Oncotarget Medium 29930766
2018 Loss of Fzd5 in endothelial cells causes G0/G1 cell cycle arrest and reduced migration; Fzd5 knockdown enhances PKC signaling and PKC/Ets1-mediated transcription of Angpt2 and Flt1, independently of canonical Wnt, NFAT, and JNK pathways. siRNA knockdown, 3D collagen co-culture, cell cycle analysis, PKC inhibition, Ets1 transcription factor assay Angiogenesis Medium 29845518
2018 WNT5A activates FZD5 to stimulate FZD5/PKC signaling, which is responsible for P-glycoprotein upregulation and multidrug resistance in renal cell carcinoma; FZD5 silencing reverses Wnt-5a-induced phosphorylation of PKCα/βII and CaMKII. siRNA knockdown, miR-124 mimic, luciferase 3'UTR assay, western blot for p-PKCα/βII and p-CaMKII Tumour biology Medium 25861751
2020 YTHDF1 promotes FZD5 mRNA translation in an m6A-dependent manner, activating the WNT/β-catenin pathway in hepatocellular carcinoma; multi-omics (ribosome profiling + m6A-seq) revealed YTHDF1 accelerates translational output specifically from FZD5 mRNA. m6A-seq, ribosome profiling, YTHDF1 knockdown/overexpression, WNT/β-catenin pathway reporters Molecular therapy. Nucleic acids Medium 33230473
2020 FZD5 promotes TNBC cell G1/S transition, DNA damage repair, and stemness through a signaling axis that activates transcription factor FOXM1, which in turn transcribes BRCA1 and BIRC5; WNT7B was identified as a specific ligand mediating these FZD5-dependent effects. Loss/gain-of-function studies, FOXM1 overexpression rescue, ChIP for FOXM1 on BRCA1/BIRC5 promoters Cell death & disease Medium 33311446
2020 FZD5 knockdown in hMSCs promotes cellular senescence via the noncanonical Wnt pathway, as shown by increased senescence markers; FZD5 overexpression delays cell cycle arrest during prolonged culture; WNT5A treatment of FZD5-expressing cells promotes proliferation. siRNA knockdown, FZD5 overexpression, senescence marker assays, proliferation assays Stem cells (Dayton, Ohio) Medium 33338299
2021 In cardiac fibroblasts, Wnt5a or Wnt11 increases FZD5 expression and activates EGFR phosphorylation; si-FZD5 suppresses increased p-EGFR and fibrotic signaling (p-p38, p-ERK), establishing a crosstalk loop between FZD5 and EGFR in cardiac fibrosis under pressure overload. siRNA knockdown, western blot, TAC mouse model, conditional medium experiments Cell death & disease Medium 34564708
2021 FZD5 prevents epithelial-mesenchymal transition (EMT) in gastric cancer through a PKC–ELF3–ZEB1 axis: FZD5 activates PKC, which induces ELF3 expression; ELF3 represses ZEB1 to block EMT; FZD5 requires co-receptor LRP5, and WNT7B is a putative FZD5 ligand in this context; FZD5 is negatively regulated by transcription factors SNAI2 and TEAD1 (ChIP). Loss/gain-of-function, ChIP-PCR, PKC inhibitor, migration assay, E-cadherin/Vimentin/ZEB1 western blot Cell communication and signaling : CCS Medium 33618713
2022 WNT5A signals through FZD5 and co-receptor LRP5 to regulate proliferation and self-renewal of endometrial mesenchymal stem-like cells (eMSC) via WNT/β-catenin; anti-FZD5 antibody and FZD5 gene silencing reduce WNT5A binding to eMSC, TCF/LEF transcriptional activity, and active β-catenin levels. Anti-FZD5 neutralizing antibody, FZD5 siRNA, TCF/LEF reporter, co-culture, Dickkopf-1 LRP inhibition Frontiers in cell and developmental biology Medium 35295855
2023 Desert lncRNA HIDEN interacts with RNA-binding protein IMP1 (IGF2BP1); HIDEN depletion reduces the IMP1–FZD5 mRNA interaction and destabilizes FZD5 mRNA, reducing WNT activity and impairing human definitive endoderm differentiation; WNT agonist rescues differentiation deficiency caused by HIDEN or IMP1 loss. shRNA/promoter deletion of HIDEN, RNA immunoprecipitation (RIP), mRNA stability assay, WNT reporter, endoderm differentiation assay Genome biology Medium 37095549
2023 Single-cell transcriptomics and functional approaches identify an endogenous WNT7A-FZD5 signaling axis as critical for fallopian tube stem cell renewal, with WNT/β-catenin pathway-activated cells forming a distinct transcriptomic cluster enriched in ECM remodeling and integrin signaling. Single-cell RNA-seq, WNT/β-catenin reporter organoids, functional knockdown/antibody blocking, bulk transcriptomics Cell reports Medium 37917586
2024 FZD5 is specifically upregulated in anterior neural progenitor cells; its expression is downregulated as cells adopt posterior fate; stimulation of a tetravalent antibody that selectively clusters FZD5 and LRP6 activates WNT/β-catenin signaling and drives midbrain progenitor differentiation into functional dopaminergic neurons in vitro and in vivo. Cell surface FZD receptor profiling, agonist antibody (FZD5/LRP6 clustering), hPSC differentiation, dopaminergic neuron functional assays, in vivo transplantation Development (Cambridge, England) High 38358799
2025 Wnt ligands specifically induce FZD5 (and FZD8) endocytosis and lysosomal degradation in a ZNRF3/RNF43-dependent manner; ZNRF3/RNF43 selectively target FZD5/8 but not other FZDs for degradation upon Wnt stimulation; Wnt promotes the physical interaction between FZD5 and RNF43; RSPO1 enhances Wnt signaling by specifically stabilizing FZD5/8; DVL promotes ligand-independent FZD endocytosis but is dispensable for Wnt-induced FZD5/8 degradation. Endocytosis and degradation assays, co-immunoprecipitation (FZD5–RNF43 interaction), RSPO1 stabilization assay, DVL loss-of-function, receptor-selective degradation profiling eLife High 41070826
2024 DNMT3A binds the FZD5 promoter to suppress its transcription via DNA methylation; reduced DNMT3A expression in NSCLC leads to FZD5 promoter hypomethylation and aberrant FZD5 upregulation; DNMT3A overexpression suppresses urethane-induced lung carcinogenesis and malignant cell behavior. Chromatin immunoprecipitation (ChIP) for DNMT3A at FZD5 promoter, quantitative methylation-specific PCR, lentiviral FZD5 silencing, mouse lung carcinogenesis model Heliyon Medium 38707304

Source papers

Stage 0 corpus · 47 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2001 Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development (Cambridge, England) 270 11092808
2016 Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nature medicine 230 27869803
2018 CircRNA circ_0067934 promotes tumor growth and metastasis in hepatocellular carcinoma through regulation of miR-1324/FZD5/Wnt/β-catenin axis. Biochemical and biophysical research communications 169 29458020
2003 Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. The Journal of biological chemistry 120 12857724
2013 A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS biology 83 23610556
2020 YTHDF1 Facilitates the Progression of Hepatocellular Carcinoma by Promoting FZD5 mRNA Translation in an m6A-Dependent Manner. Molecular therapy. Nucleic acids 60 33230473
2007 Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. International journal of oncology 44 17273778
2021 miR-100-5p in human umbilical cord mesenchymal stem cell-derived exosomes mediates eosinophilic inflammation to alleviate atherosclerosis via the FZD5/Wnt/β-catenin pathway. Acta biochimica et biophysica Sinica 42 34254638
2020 FZD5 contributes to TNBC proliferation, DNA damage repair and stemness. Cell death & disease 42 33311446
2018 FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs. Science signaling 42 30514810
2021 Down-regulated LINC00115 inhibits prostate cancer cell proliferation and invasion via targeting miR-212-5p/FZD5/Wnt/β-catenin axis. Journal of cellular and molecular medicine 39 34697900
2016 A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant coloboma. Human molecular genetics 36 26908622
2014 Monocyte-secreted Wnt5a interacts with FZD5 in microvascular endothelial cells and induces angiogenesis through tissue factor signaling. Journal of molecular cell biology 35 25240054
2018 Role of WNT5A receptors FZD5 and RYK in prostate cancer cells. Oncotarget 32 29930766
2021 Cardiac Wnt5a and Wnt11 promote fibrosis by the crosstalk of FZD5 and EGFR signaling under pressure overload. Cell death & disease 29 34564708
2015 miR-124 represses FZD5 to attenuate P-glycoprotein-mediated chemo-resistance in renal cell carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 29 25861751
2021 FZD5 prevents epithelial-mesenchymal transition in gastric cancer. Cell communication and signaling : CCS 28 33618713
2020 FZD5 regulates cellular senescence in human mesenchymal stem/stromal cells. Stem cells (Dayton, Ohio) 27 33338299
2008 Wnt7a interaction with Fzd5 and detection of signaling activation using a split eGFP. Biochemical and biophysical research communications 27 18230341
2018 MiR-212-5p regulates the proliferation and apoptosis of AML cells through targeting FZD5. European review for medical and pharmacological sciences 24 30556883
2009 A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5). The Journal of biological chemistry 23 19643732
2022 WNT5A Interacts With FZD5 and LRP5 to Regulate Proliferation and Self-Renewal of Endometrial Mesenchymal Stem-Like Cells. Frontiers in cell and developmental biology 20 35295855
2018 Endothelial loss of Fzd5 stimulates PKC/Ets1-mediated transcription of Angpt2 and Flt1. Angiogenesis 19 29845518
2017 MiR-99a inhibits keratinocyte proliferation by targeting Frizzled-5 (FZD5) / FZD8 through β-catenin signaling in psoriasis. Die Pharmazie 19 29441905
2023 A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA. Genome biology 17 37095549
2021 CircNPM1 strengthens Adriamycin resistance in acute myeloid leukemia by mediating the miR-345-5p/FZD5 pathway. Central-European journal of immunology 17 34764785
2020 Confirmation of FZD5 implication in a cohort of 50 patients with ocular coloboma. European journal of human genetics : EJHG 15 32737437
2021 IgD promotes pannus formation by activating Wnt5A-Fzd5-CTHRC1-NF-κB signaling pathway in FLS of CIA rats and the regulation of IgD-Fc-Ig fusion protein. International immunopharmacology 12 34688134
2021 The fluorescent biosensor for detecting N6 methyladenine FzD5 mRNA and MazF activity. Analytica chimica acta 12 34794576
2023 Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids. Cell reports 11 37917586
2015 Wnt5a/FZD5/CaMKII signaling pathway mediates the effect of BML-111 on inflammatory reactions in sepsis. International journal of clinical and experimental medicine 11 26770375
2023 Sfrp2 promotes renal dysfunction of diabetic kidney disease via modulating Fzd5-induced cytosolic calcium ion concentration and CaMKII/Mek/Erk pathway in mesangial cells. Biochimica et biophysica acta. Molecular basis of disease 10 37951508
2019 Upregulation of FZD5 in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps by Epigenetic Modification. Molecules and cells 8 31082802
2024 Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification. Development (Cambridge, England) 6 38358799
2022 Individuals with heterozygous variants in the Wnt-signalling pathway gene FZD5 delineate a phenotype characterized by isolated coloboma and variable expressivity. Ophthalmic genetics 6 36695497
2020 miR-149 regulates the proliferation and apoptosis of human colonic carcinoma cells by targeting FZD5. International journal of clinical and experimental pathology 6 32509059
2018 MicroRNA-216b actively modulates diabetic angiopathy through inverse regulation on FZD5. Gene 6 29477872
2016 [Role and action mechanisms of FZD5 in prostate cancer bone metastasis in mice]. Zhonghua nan ke xue = National journal of andrology 5 26939396
2024 circ_0000592 facilitates the progression of esophageal squamous cell carcinoma via miR-155-5p/FZD5 axis. Journal of biochemical and molecular toxicology 4 38780005
2020 Retracted Article: CircBANP acts as a sponge of let-7a to promote gastric cancer progression via the FZD5/Wnt/β-catenin pathway. RSC advances 4 35493872
2024 DNMT3A-mediated DNA methylation and transcription inhibition of FZD5 suppresses lung carcinogenesis. Heliyon 3 38707304
2025 Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL. bioRxiv : the preprint server for biology 1 39463927
2025 ZNF831-YTHDF1-DNMT1/3a feedback loop regulates lung carcinogenesis and progression through WNT7B-FZD5-β-catenin signalling axis. Free radical biology & medicine 1 40975192
2022 Generation of a BAC transgenic mouse strain that expresses CreERT and a fluorescent protein under the transcriptional control of the Fzd5 locus. Inflammation and regeneration 1 35227325
2025 Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL. eLife 0 41070826
2023 Age and light damage influence Fzd5 regulation of ocular growth-related genes. Experimental eye research 0 38154732
2021 Retraction: CircBANP acts as a sponge of let-7a to promote gastric cancer progression via the FZD5/Wnt/β-catenin pathway. RSC advances 0 35427047