Affinage

WASF2

Actin-binding protein WASF2 · UniProt Q9Y6W5

Length
498 aa
Mass
54.3 kDa
Annotated
2026-06-11
100 papers in source corpus 50 papers cited in narrative 50 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

WASF2 (WAVE2) is a nucleation-promoting factor that converts upstream Rac and phosphoinositide signals into branched actin polymerization at the cell periphery, driving lamellipodia, membrane ruffles, and directed migration (PMID:14536061, PMID:12853475). It functions as the core catalytic subunit of a pentameric complex with Abi1, Nap1, PIR121/Sra-1, and HSPC300, which is fully competent to stimulate the Arp2/3 complex and relocalizes to the leading edge upon Rac activation (PMID:15048123). Membrane recruitment and activation are governed by the WAVE2 basic region binding PtdIns(3,4,5)P3 produced by PI3K (PMID:15107862), by IRSp53 linking active Rac to the membrane-associated complex (PMID:16702231, PMID:18198193), and by the basic region engaging ADP-actin filaments to enhance Arp2/3 branching (PMID:11792818, PMID:11401525). Genetic ablation confirms a non-redundant requirement for WAVE2 in Rac/PDGF-driven lamellipodium formation and motility, and in VEGF-dependent endothelial sprouting during angiogenesis, where loss causes embryonic lethality with hemorrhage (PMID:12879075, PMID:12853475). WAVE2 activity is tuned by a network of phosphorylation events: Abi1-dependent recruitment of Abl kinase phosphorylates Tyr150 to activate the complex (PMID:15657136, PMID:16899465), Cdk5 phosphorylates Ser137 (PMID:18701695), and ERK phosphorylates the proline-rich and VCA regions (including Thr346/Ser351) to control protrusion, persistence, and Golgi polarization (PMID:21419341, PMID:18032787, PMID:29162704); CK2 phosphorylation of VCA serines modulates Arp2/3 binding and activation (PMID:19012317). Complex integrity itself is a control point, as Abi1, Nap1/Hem-1, and HSPC300 are each required for WAVE2 stability, and release of WRC autoinhibition upon activation exposes Lys45 to ubiquitylation and proteasomal degradation (PMID:21482783, PMID:29915352, PMID:28332566). Beyond actin nucleation, WAVE2 serves broader roles in immune cells: at the T cell immunological synapse it couples Arp2/3-driven F-actin to vinculin/talin recruitment and integrin affinity maturation via an Abl–CrkL–C3G–Rap1 axis (PMID:17591693, PMID:18809728), and it directly binds and inhibits mTOR—impeding RAPTOR and RICTOR association—to restrain mTOR signaling and prevent autoimmunity (PMID:33766857). WAVE2 is also exploited by pathogens for actin-dependent invasion and by tumor cells for Rac-driven invasion and metastasis (PMID:15608687, PMID:15929989).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2001 High

    Established that beyond the canonical VCA module, the WAVE2 basic region directly engages actin filaments and is itself essential for actin-based motility, refining how the protein nucleates branched networks.

    Evidence In vitro actin branching and bead-motility assays in brain cytosol with deletion constructs

    PMID:11401525 PMID:11792818

    Open questions at the time
    • Did not place the basic region in the context of the assembled pentameric complex
    • Structural basis of ADP-filament recognition not resolved
  2. 2003 High

    Defined non-redundant, isoform-specific roles by showing WAVE2 is required for peripheral ruffling and directed migration downstream of Rac/PDGF in vivo, distinct from WAVE1.

    Evidence Gene-specific siRNA and knockout mice/MEFs with migration and lamellipodia readouts; angiogenesis phenotype

    PMID:12853475 PMID:12879075 PMID:14536061

    Open questions at the time
    • Molecular composition of the active complex not yet defined
    • Mechanism of Rac-to-WAVE2 coupling unresolved at this stage
  3. 2004 High

    Resolved the activation input architecture by identifying the WAVE2–Abi1–Nap1–PIR121 complex and showing PtdIns(3,4,5)P3 recruits WAVE2 to the membrane via its basic domain.

    Evidence Tandem MS, Co-IP, in vitro Arp2/3 assays, lipid-binding assays, mutant rescue, RNAi

    PMID:15048123 PMID:15107862

    Open questions at the time
    • How lipid binding and Rac signaling are integrated kinetically not defined
    • HSPC300 not yet placed in the complex here
  4. 2005 High

    Identified the first activating phosphorylation, establishing Abi1-dependent Abl phosphorylation of WAVE2 Tyr150 as required for activation and membrane translocation.

    Evidence Co-IP, in vitro/in vivo kinase assays, Y150F mutagenesis, Abl/Arg-null fibroblasts

    PMID:15657136 PMID:16899465

    Open questions at the time
    • How Tyr150 phosphorylation alters WRC conformation not defined
    • Stimulus specificity of Abl recruitment unresolved
  5. 2006 High

    Spatially resolved activation by showing only the membrane-associated WAVE2 complex is Arp2/3-active, and is switched on by IRSp53 in a Rac/PIP3-dependent manner.

    Evidence Membrane fractionation, purified-protein reconstitution with PIP3 liposomes, IRSp53 RNAi

    PMID:16702231

    Open questions at the time
    • Why cytosolic complex is inactive at the molecular level not fully defined
    • IRSp53 stoichiometry within the complex unresolved
  6. 2006 High

    Extended WAVE2 function to immune cells, defining its requirement at the T cell synapse for actin reorganization, integrin adhesion, and calcium entry distal to PLCγ1.

    Evidence Co-IP, RNAi, live imaging, calcium flux and integrin adhesion assays

    PMID:16401421

    Open questions at the time
    • Link between actin and CRAC channel activation mechanistically unclear
    • Identity of the WAVE2 biochemical modification not defined here
  7. 2008 High

    Dissected synapse signaling output, showing WAVE2 recruits Abl and the CrkL–C3G complex to activate Rap1 and control integrin affinity maturation, and identified Cdk5/Ser137 as a migration-controlling input in neural cells.

    Evidence Co-IP, RNAi, dominant-negatives, Rap1 activation assays; in vitro kinase assay and S137A mutagenesis

    PMID:18701695 PMID:18809728

    Open questions at the time
    • How distinct phosphosites are coordinated not defined
    • Whether Rap1 axis operates outside T cells unknown
  8. 2011 High

    Established complex stability as a regulatory node and identified ERK as a direct WRC kinase required for productive Arp2/3 engagement during protrusion.

    Evidence Abi1 conditional KO with complex Western blots; in vitro ERK kinase assay with phospho-mutant rescue and protrusion assays

    PMID:21419341 PMID:21482783

    Open questions at the time
    • Identity of the WAVE2 ubiquitin ligase not addressed
    • How ERK phosphorylation integrates with Abl/CK2 inputs unclear
  9. 2017 Medium

    Connected conformation to turnover, showing WRC autoinhibition stabilizes WAVE2 while activation exposes Lys45 for ubiquitylation and degradation.

    Evidence FRET conformational sensing, K45 mutagenesis, ubiquitylation and proteasome-inhibitor assays in T cells

    PMID:28332566

    Open questions at the time
    • Responsible E3 ligase not identified
    • Single-lab finding awaiting independent confirmation
  10. 2018 Medium

    Revealed actin-independent functions of the complex—WAVE2 stabilization by LRRK2 phosphorylation in disease and Hem-1-dependent Abl survival signaling separable from actin dynamics.

    Evidence In vitro kinase assays, Co-IP, proteasome inhibition, KO mouse models and HSC transplantation

    PMID:29760073 PMID:29915352

    Open questions at the time
    • Whether LRRK2 and Abl phosphosites cooperate unknown
    • Mechanism linking complex to survival signaling not fully defined
  11. 2021 High

    Demonstrated a non-actin role: WAVE2 directly binds and inhibits mTOR by blocking RAPTOR/RICTOR association, maintaining T cell homeostasis and preventing autoimmunity.

    Evidence T cell-specific conditional KO, Co-IP, mTOR-inhibitor rescue, phosphoproteomics

    PMID:33766857

    Open questions at the time
    • Structural basis of WAVE2–mTOR binding undefined
    • Whether mTOR inhibition occurs outside T cells unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the many phosphorylation, ubiquitylation, and scaffolding inputs are integrated in time and space to switch a single WAVE2 molecule between actin-nucleating and mTOR-inhibitory states remains unresolved.
  • No unified structural model of the activated, membrane-bound, phosphorylated WRC
  • Relative contributions of competing kinases (Abl, ERK, Cdk5, CK2, LRRK2) under a given stimulus undefined
  • Identity of the K45 ubiquitin ligase unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 3 GO:0060090 molecular adaptor activity 3 GO:0008289 lipid binding 1 GO:0098772 molecular function regulator activity 1
Localization
GO:0005886 plasma membrane 3 GO:0005856 cytoskeleton 2 GO:0005829 cytosol 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-168256 Immune System 3 R-HSA-1266738 Developmental Biology 2 R-HSA-1643685 Disease 2
Partners
ABI1ABL1BAIAP2CTTNCYFIP1MTORMYH9NCKAP1
Complex memberships
WAVE regulatory complex (WAVE2-Abi1-Nap1-PIR121/Sra-1-HSPC300)

Evidence

Reading pass · 50 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 Abi1 directly binds the WHD domain of WAVE2, increases WAVE2 actin polymerization activity in vitro, and mediates assembly of a WAVE2-Abi1-Nap1-PIR121 complex identified by tandem mass spectrometry. This complex is as active as WAVE2-Abi1 sub-complex in stimulating Arp2/3, and re-localizes to the leading edge of ruffles following Rac activation. RNAi inhibition of Abi1 abrogates Rac-dependent lamellipodia protrusion. Tandem mass spectrometry, Co-IP, in vitro actin polymerization assay, RNAi knockdown, live-cell imaging Nature cell biology High 15048123
2003 WAVE2 is specifically required for peripheral ruffle formation and directed cell migration (without ECM) downstream of PDGF stimulation in fibroblasts, whereas WAVE1 is required for dorsal ruffle formation. Loss of WAVE2 impairs leading-edge extension for directed migration. Gene-specific siRNA knockdown, live-cell migration assays, immunofluorescence Developmental cell High 14536061
2004 WAVE2 binds PtdIns(3,4,5)P3 through its basic domain. PtdIns(3,4,5)P3 produced by PI(3)K at the cell membrane is sufficient to recruit WAVE2 to the polarized membrane even in the presence of dominant-negative Rac; a lipid-binding-deficient full-length WAVE2 mutant inhibits proper lamellipodia formation. Lipid-binding assays, myristoylated PI3K expression, dominant-negative Rac, mutant WAVE2 expression, fluorescence microscopy Nature cell biology High 15107862
2003 Genetic disruption of WAVE2 in mice causes embryonic lethality (~E10) with haemorrhages and impaired angiogenic sprouting/branching of endothelial cells; WAVE2-null endothelial cells fail to form lamellipodia at leading edges in response to VEGF, establishing WAVE2 as essential for Rac-regulated actin reorganization during angiogenesis in vivo. Gene-targeted knockout mouse, embryological analysis, endothelial cell migration and lamellipodia assays Nature High 12879075
2003 WAVE2-deficient mouse embryonic fibroblasts exhibit severe defects in cell motility, lamellipodium formation, and Rac-mediated actin polymerization in response to PDGF, while proliferation is normal, establishing a non-redundant role for WAVE2 downstream of Rac in actin-based cell movement. Gene-targeted knockout mouse/MEFs, PDGF stimulation, actin polymerization and cell migration assays The EMBO journal High 12853475
2005 Abi-1 couples WAVE2 to Abl kinase after cell stimulation, promoting Abl-mediated tyrosine phosphorylation of WAVE2 at Y150, which is required for WAVE2 activation, actin polymerization induction, and membrane translocation with activated Rac. Mutation of Y150 or disruption of WAVE2-Abi-1 binding impairs membrane actin rearrangement; Abl/Arg-null fibroblasts fail to phosphorylate WAVE2 or form membrane actin rearrangements. Co-IP, in vitro and in vivo phosphorylation assays, site-directed mutagenesis (Y150F), RNAi, fibroblast knockout cells Proceedings of the National Academy of Sciences of the United States of America High 15657136
2006 c-Abl interacts with the WAVE2 complex via Abi-1 and phosphorylates WAVE2 on tyrosine 150 to activate membrane ruffling; WAVE2-Y150F rescue cells fail to ruffle or form microspikes, and RNAi of WAVE2 in Abl/Arg-null cells has no additive effect on membrane ruffling, placing Abl upstream of WAVE2 in this pathway. Co-IP, in vitro kinase assay, site-directed mutagenesis (Y150F), RNAi, genetic epistasis in Abl/Arg-null cells The Journal of biological chemistry High 16899465
2006 WAVE2 complex (with Sra1/PIR121, Nap1, Abi1, HSPC300) isolated from the membrane fraction is fully active in stimulating Arp2/3 in an IRSp53-dependent manner in vitro, while cytosolic WAVE2 complex is not. Purified WAVE2 and WAVE2 complex are activated by IRSp53 in a Rac-dependent manner with PIP3-containing liposomes; IRSp53 knockdown reduces lamellipodia formation without decreasing WAVE2 complex levels. In vitro Arp2/3 activity assay, membrane fractionation, IRSp53 RNAi, purified protein reconstitution with PIP3 liposomes The Journal of cell biology High 16702231
2011 ERK directly phosphorylates both WAVE2 and Abi1 within the WRC at lamellipodial leading edges. These phosphorylations are required for functional WRC interaction with Arp2/3 and actin during cell protrusion, as shown by phospho-deficient mutants failing to support protrusion. In vitro kinase assay, phospho-mutant analysis, co-localization by microscopy, cell protrusion assay Molecular cell High 21419341
2006 WAVE2 is recruited to the T cell immunological synapse following TCR crosslinking, undergoes biochemical modification, and is required for actin cytoskeletal reorganization, beta-integrin-mediated adhesion, and calcium entry at a step distal to PLCgamma1 activation and IP3-mediated store release (CRAC channel activation). Co-IP, RNAi knockdown, live-cell imaging, calcium flux assays, integrin adhesion assays Current biology : CB High 16401421
2007 WAVE2 VCA domain mediates formation of an Arp2/3-vinculin-talin signaling complex at the T cell immunological synapse; TCR stimulation induces WAVE2-ARP2/3-dependent F-actin nucleation leading to talin recruitment and high-affinity integrin binding to VCAM-1. Vinculin is required for talin recruitment but not for F-actin or integrin accumulation. RNAi knockdown, Co-IP, immunofluorescence, integrin binding assay (VCAM-1) Molecular and cellular biology High 17591693
2008 The WAVE2 complex associates with Abl tyrosine kinase in T cells; TCR ligation induces WAVE2-dependent membrane recruitment of Abl. WAVE2 regulates TCR-mediated Rap1 activation via recruitment of CrkL-C3G exchange complex; Abl phosphorylates C3G to enable its GEF activity toward Rap1, controlling integrin clustering and affinity maturation. Co-IP, RNAi, dominant-negative constructs, Rap1 activation assay, integrin clustering assay The Journal of cell biology High 18809728
2008 Cdk5 phosphorylates WAVE2 at Ser-137 in vitro, downstream of Fyn kinase activation by PDGF, to control oligodendrocyte precursor cell migration. WAVE2-S137A mutant impairs PDGF-dependent OPC migration. In vitro kinase assay, site-directed mutagenesis (S137A), retroviral shRNA knockdown, cell migration assay The Journal of neuroscience : the official journal of the Society for Neuroscience High 18701695
2018 LRRK2 binds WAVE2 and phosphorylates it at Thr470, stabilizing WAVE2 and preventing its proteasomal degradation. LRRK2-G2019S (gain-of-function PD mutation) causes increased WAVE2-mediated phagocytic responses in macrophages/microglia; Lrrk2 loss causes the opposite. WAVE2 mediates LRRK2-G2019S-induced dopaminergic neuronal death. Co-IP, in vitro kinase assay, proteasome inhibitor treatment, siRNA knockdown, macrophage/microglia phagocytosis assay, in vivo mouse model Proceedings of the National Academy of Sciences of the United States of America High 29760073
2021 Conditional T cell-specific ablation of WAVE2 causes severe autoimmunity with increased mTOR activation. WAVE2 directly bound mTOR and inhibited its activation by impeding mTOR interactions with RAPTOR and RICTOR. Both T cell defects and autoimmunity were ameliorated by pharmacological mTOR inhibitors. Conditional KO mouse, Co-IP (WAVE2-mTOR direct binding), mTOR inhibitor rescue, phosphoproteomic/metabolic analysis Science (New York, N.Y.) High 33766857
2010 Dysbindin-1 forms a ternary complex with WAVE2 and Abi-1 in neurons (but not N-WASP); dysbindin-1 promotes binding of WAVE2 to Abi-1. RNAi knockdown of dysbindin-1 generates abnormally elongated immature dendritic protrusions, implicating the complex in dendritic spine morphogenesis. Co-IP, immunofluorescence, RNAi knockdown in hippocampal neurons Molecular psychiatry Medium 20531346
2007 ERK2 directly phosphorylates WAVE2 in vitro at sites in the proline-rich region and VCA domain. Phosphorylation of the VCA region increases its affinity for Arp2/3 but paradoxically reduces Arp2/3-mediated actin polymerization activity in vitro. In vitro kinase assay with ERK2, actin polymerization assay, binding assay Journal of biochemistry Medium 17202194
2007 MAP kinase phosphorylation sites within WAVE2 regulate persistent cell migration and Golgi polarization; fibroblasts expressing phospho-defective WAVE2 show increased migration speed, decreased persistence, and disrupted Golgi polarization—effects mimicked by acute WAVE2 RNAi knockdown. Site-directed mutagenesis of MAP kinase phosphosites, transgene expression, scratch-wound migration assay, RNAi Journal of cell science Medium 18032787
2009 Casein kinase 2 (CK2) phosphorylates five serine residues (482, 484, 488, 489, 497) in the WAVE2 VCA domain; phosphorylation is required for high-affinity Arp2/3 interaction, while phosphorylation of Ser482/484 specifically inhibits Arp2/3 activation. Non-phosphorylatable alanine mutations inhibit WAVE2-dependent cell ruffling and leading-edge integrity in vivo. In vitro CK2 phosphorylation, mutagenesis, Arp2/3 binding/activation assay, cell ruffling assay Cell motility and the cytoskeleton Medium 19012317
2011 Abi1 knockout cells display reduced WAVE1 and WAVE2 protein levels along with Nap1 and Sra-1/PIR121, demonstrating that Abi1 is required for the stability and integrity of the entire WAVE complex. Abi1 KO causes decreased migration rate and distance but increased directional persistence, without affecting peripheral ruffling but impairing dorsal ruffling. Conditional Abi1 KO mouse/MEFs, Western blot of complex components, migration assays Proceedings of the National Academy of Sciences of the United States of America High 21482783
2001 The basic region of WAVE2 (between WH1 and CRIB domains) binds ADP actin filaments, enhancing Arp2/3 branching efficiency on pre-existing ADP filaments by ~2-fold compared to VCA domain alone. This basic region is required for actin-based bead motility in cytosol; VCA domain alone or constructs lacking the basic region fail to support bead movement. In vitro actin polymerization/branching assay, bead motility assay in brain cytosol, deletion constructs Journal of cell science High 11792818
2001 The basic region of WAVE2 is required for actin-based motility in cell extracts; beads coated with full-length WAVE2 but not WAVE2 lacking the basic clusters (Delta basic) or VCA alone support movement in brain cytosol, and VCA/Delta-basic constructs are much less able to induce actin polymerization in cytosol. Polystyrene bead motility assay in brain cytosol, in vitro actin polymerization assay, deletion constructs Biochemical and biophysical research communications High 11401525
2005 WAVE2 is required for Rac1-induced membrane ruffling, invasion into ECM, and pulmonary metastasis of B16F10 melanoma cells. WAVE2 acts as the primary downstream effector of Rac to achieve invasion; co-expression of RacCA and WAVE2 in parental B16 cells additively increases invasiveness beyond RacCA alone. RNAi knockdown, constitutively active Rac co-expression, Matrigel invasion assay, in vivo metastasis assay Oncogene High 15608687
2010 WAVE2 directly binds Abl kinase and activates HIV-1 Arp2/3-dependent actin polymerization; Tiam-1 (Rac GEF) associates with IRSp53 to link Rac to the WAVE2 complex. Rac and Abl activate the WAVE2 complex for pore expansion at the hemifusion stage of HIV-1 entry; siRNA knockdown of WAVE2, Abl, IRSp53, or Arp3 attenuates HIV-1 fusion and infection. siRNA knockdown, fusion assay, virus-cell infection assay, Abl kinase inhibitors (imatinib, nilotinib, dasatinib), fluorescence microscopy with membrane curving agents PLoS pathogens Medium 20585556
2014 HIV-1 gp120 binding to CXCR4 or CCR5 triggers WAVE2 phosphorylation at serine 351 via both Gαi-dependent and -independent pathways; WAVE2-mediated Arp2/3 activity is required for HIV-1 nuclear migration. Stable shRNA knockdown of Arp3 or Arp2/3 inhibitor CK548 prevented HIV-1 nuclear migration and infection of CD4 T cells. Phosphorylation mapping, shRNA knockdown, Arp2/3 inhibitor, HIV-1 infection/nuclear migration assay in primary cells The Journal of biological chemistry Medium 24415754
2011 IL-2 activates WAVE2 in NK cells to enable WASp-independent F-actin accumulation at the immunological synapse and NK cell cytotoxicity. WAVE2 was required for IL-2-induced WASp-independent NK function but not for baseline innate NK activity, defining WAVE2 and WASp as parallel pathways to F-actin reorganization. WASp inhibitor, WAS patient cells, siRNA knockdown of WAVE2, NK cytotoxicity assay, F-actin quantification at IS The Journal of clinical investigation Medium 21383498
2011 WAVE2 regulates meiotic spindle stability, peripheral positioning, and polar body emission in mouse oocytes via an actin-mediated pathway. siRNA-mediated and antibody-mediated disruption of WAVE2 causes failure of chromosome congression, spindle formation, spindle positioning, polar body extrusion, actin cap and cortical granule-free domain formation. WAVE2 regulation of chromosome migration is independent of microtubules. siRNA knockdown, antibody microinjection, immunofluorescence, nocodazole treatment (microtubule depletion) Cell cycle (Georgetown, Tex.) Medium 21543895
2009 Pak1 constitutively binds WAVE2 and is transported with WAVE2 to the leading edge upon HGF stimulation. Pak1 mediates kinesin-dependent WAVE2 transport along microtubules by phosphorylating stathmin/Op18 at Ser38 and recruiting phospho-stathmin to the kinesin-WAVE2 complex. Pak1 inhibition or depletion abrogates HGF-induced WAVE2 transport and lamellipodia formation. Co-IP, siRNA knockdown of Pak1, Pak1 inhibitor (IPA-3), phospho-specific antibodies, lamellipodia assay Cellular signalling Medium 19162178
2008 Kinesin heavy chain KIF5B forms a complex with WAVE2 and IQGAP1; HGF-induced WAVE2 transport to the cell periphery and lamellipodia formation require KIF5B-mediated transport along microtubules in a Rac1-dependent manner. Downregulation of KIF5B or microtubule depolymerization abrogates WAVE2 transport. Co-IP (WAVE2-KIF5B), siRNA knockdown of KIF5B, nocodazole treatment, lamellipodia quantification Experimental cell research Medium 18514191
2010 PKA forms a complex with WAVE2 in breast cancer cells and brain extracts; two separate regions of WAVE2 mediate PKA binding. WAVE2 serves as an A-kinase-anchoring protein (AKAP) that recruits PKA to membrane protrusions; WAVE2 depletion impairs PKA localization at protrusions and PKA activation-induced enlargement of membrane protrusions. Co-IP, siRNA knockdown, PKA activator treatment, immunofluorescence of protrusion size The Journal of biological chemistry Medium 21119216
2007 WAVE2 complex is required for Rac-Abi-1-dependent actin recruitment and entry of Chlamydia trachomatis into epithelial cells; siRNA depletion of WAVE2 and Abi-1 abrogates chlamydia-induced actin recruitment and significantly reduces pathogen uptake. C. trachomatis infection promotes Rac interaction with WAVE2 and Abi-1 but not with IRSp53. Co-IP, siRNA knockdown, bacterial invasion/infection assay, immunofluorescence Cellular microbiology Medium 17501982
2005 WAVE2-Abi1 complex is required for CSF-1-induced F-actin protrusions and macrophage migration. WAVE2 and Abi1 are co-recruited to protrusions; reducing WAVE2 by dominant-negative, antibody, or RNAi impairs CSF-1-elicited actin protrusions, and targeting Abi1 reduces WAVE2 levels and impairs migration. Dominant-negative expression, antibody microinjection, RNAi, Co-IP, cell migration assay Journal of cell science Medium 16280551
2008 Membrane targeting of WAVE2 alone is insufficient for WAVE2-dependent actin polymerization; IRSp53 links Rac1 to WAVE2-Abi1 in a Rac1-activation-dependent immunoprecipitable complex in macrophages. Reduction of IRSp53 or expression of IRSp53 lacking the WAVE2-binding SH3 domain significantly reduces Rac1 association with WAVE2 and Abi1, and diminishes CSF-1-induced protrusions and migration. RNAi, Co-IP, dominant-negative IRSp53, membrane-targeted WAVE2 expression, migration/protrusion assays Journal of cell science Medium 18198193
2014 Cortactin directly binds both WAVE2 and Arp2/3 at the epithelial zonula adherens; both interactions are necessary for actin assembly at the ZA. Cortactin binding to the cadherin cytoplasmic tail was demonstrated by cell-free protein expression and fluorescent single-molecule coincidence assays. Cell-free protein expression, fluorescent single-molecule coincidence assay, siRNA knockdown, in vitro binding assays The Journal of biological chemistry Medium 24469447
2011 WAVE2 and mDia1 interact directly with IRSp53 within filopodia, as shown by acceptor photobleaching FRET. mDia1 and WAVE2 synergize with IRSp53 to form filopodia; depletion of either mDia1 or WAVE2 decreases IRSp53-induced filopodia formation. Acceptor photobleaching FRET, siRNA knockdown, time-lapse imaging of filopodium formation The Journal of biological chemistry Medium 22179776
2012 WAVE2-Abi2 complex activity is regulated by Abl kinase (via Y150 phosphorylation) and Cdk5 (via S137 phosphorylation) to control growth cone activity and the multipolar-to-bipolar neuronal transition, as well as initiation of glia-guided migration in the developing neocortex. In utero electroporation, mutagenesis (Y150, S137), time-lapse imaging of migrating neurons Cerebral cortex (New York, N.Y. : 1991) Medium 22617848
2005 WAVE2 is required for efficient invasion of polarized epithelial cells by Salmonella typhimurium. Disruption of the PIR121/Nap1/Abi1/WAVE2/HSPC300 pentameric complex potently inhibits bacterial uptake, while the IRSp53/WAVE2 complex is not required for invasion despite being formed during infection. siRNA knockdown, dominant-negative complex disruption, bacterial invasion/internalization assay The Journal of biological chemistry Medium 15929989
2004 N-WASP and WAVE2 act downstream of phosphatidylinositol 3-kinase to mediate HGF-induced lamellipodia formation and myogenic cell migration; dominant-negative WAVE2 or WAVE2 RNAi prevents HGF-induced lamellipodial formation and both non-directional and directional migration of C2C12 myoblasts. Dominant-negative expression, RNAi knockdown, PI3K inhibitor (LY294002), cell migration and chemotaxis assays The Journal of biological chemistry Medium 15496413
2010 Nonmuscle myosin IIA (MYH9) constitutively associates with WAVE2 in a myosin II activity-dependent manner; the MYH9-WAVE2 complex co-localizes to PIP3 at the leading edge after IGF-I stimulation. Depletion of MYH9 or inhibition of myosin II by blebbistatin abrogates F-actin arc and lamellipodia formation, indicating MYH9 is required for lamellipodia through binding to WAVE2. Co-IP (identified by mass spectrometry), siRNA knockdown, blebbistatin treatment, immunofluorescence Biochemical and biophysical research communications Medium 21184743
2015 Cortactin phosphorylation on S405/S418 by PLCβ3-PKCδ downstream of MCP1/CCR2/Gαq11 signaling is required for cortactin interaction with WAVE2; this interaction mediates G-actin polymerization, F-actin stress fiber formation, and smooth muscle cell migration. Co-IP, siRNA knockdown of PLCβ3/PKCδ/CCR2/Gαq11, phosphomimetic/phosphodeficient mutants, actin polymerization and migration assays Molecular biology of the cell Medium 26490115
2012 SKAP2 physically associates with both WAVE2 and cortactin and inhibits their interaction; cortactin is required for membrane localization of WAVE2, and SKAP2 suppresses WAVE2/cortactin-mediated actin polymerization in vitro. SKAP2 knockdown enhances WAVE2 translocation to cell membrane and accelerates cell migration in a SKAP2-WAVE2 binding-dependent manner. Co-IP, in vitro actin polymerization assay, siRNA knockdown, cell migration assay, binding-deficient mutant The Journal of biological chemistry Medium 23161539
2017 Following T cell activation, WAVE2 undergoes ubiquitylation at lysine 45 (mapped by mutagenesis), leading to proteasomal degradation. The autoinhibitory conformation of the WRC stabilizes WAVE2 in resting cells (shown by FRET); release of autoinhibition upon activation exposes K45 to ubiquitylation and degradation. FRET (to detect WRC conformational state), ubiquitylation assays, mutagenesis (K45), proteasome inhibitor treatment, T cell activation Scientific reports Medium 28332566
2014 WAVE2 recruitment to the TCR signaling site requires ZAP-70, LAT, SLP-76, and Nck (similar to WASp). However, unlike WASp, WAVE2 leaves this complex and migrates peripherally with vinculin to the membrane leading edge. These dynamics were demonstrated using FRET and triple-color FRET technology in live T cells. FRET, triple-color FRET (3FRET), siRNA knockdown, live T cell imaging The Journal of biological chemistry Medium 25342748
2018 Hem-1 (Nap1) scaffold loss leads to degradation of the entire WAVE2 complex and loss of c-Abl survival signaling from the complex, causing failure of fetal liver HSC engraftment in bone marrow. This engraftment defect is not due to defects in actin-dependent chemotaxis, homing, or adhesion, but to loss of Abl signaling. Hem-1 KO mouse, HSC transplantation, homing/migration/adhesion assays, Western blot of complex components, Abl signaling analysis Nature communications Medium 29915352
2006 Vinexin beta interacts with the proline-rich region of WAVE2 through its first and second SH3 domains and increases WAVE2 protein levels by reducing proteasomal degradation in a PKA-dependent manner. PKA activation alone increases WAVE2 expression; PKA inhibition suppresses vinexin-induced WAVE2 increase. Co-IP, domain mapping by mutagenesis, proteasome inhibitor treatment, PKA activation/inhibition, Western blot Genes to cells : devoted to molecular & cellular mechanisms Medium 16483316
2015 NESH/Abi-3 forms a WAVE2 complex that is functionally distinct from the Abi-1-based WAVE2 complex: NESH/Abi-3 neither binds c-Abl nor promotes c-Abl-mediated WAVE2 phosphorylation, and expression of NESH/Abi-3 reduces WAVE2 translocation to the plasma membrane and disrupts lamellipodial protrusion. A linker region between proline-rich regions and the SH3 domain of Abi-1 is required for its c-Abl interaction and c-Abl-mediated WAVE2 phosphorylation. Co-IP, domain mapping, imatinib inhibition, siRNA, fluorescence microscopy of WAVE2 localization Cell communication and signaling : CCS Medium 26428302
2016 TrkC activation by neurotrophin-3 leads to ERK-dependent phosphorylation of WAVE2 at Thr346 and Ser351, causing a WAVE2 mobility shift; mutagenesis of these sites or ERK inhibition abolishes TrkC-induced WAVE2 shift and podocyte migration. WAVE2 shRNA knockdown abolishes TrkC-induced podocyte migration. Mutagenesis of ERK phosphosites (T346/S351), ERK inhibition, shRNA knockdown, podocyte migration assay FASEB journal : official publication of the Federation of American Societies for Experimental Biology Medium 29162704
2013 WAVE2 knockdown in 3D epithelial acini causes cadherin isoform switching (decreased E-cadherin, increased N-cadherin) and upregulation of Twist1 mRNA; knockdown of Twist1 in WAVE2-KD cells reverses cadherin switching and rescues the aberrant morphological phenotype. Abl kinase activity is increased in WAVE2-KD cells, and Abl inhibition rescues the multi-lobular phenotype, placing WAVE2 upstream as a repressor of Abl/Twist1 activity. shRNA knockdown, 3D acini culture, Abl inhibitor (STI571), Twist1 knockdown rescue, qRT-PCR, immunostaining PloS one Medium 23691243
2020 WAVE1 and WAVE2 are redundant for lamellipodia formation and motility in B16-F1 melanoma cells; however, WAVE2 KO decreases the rate of leading-edge actin extension while WAVE1 KO increases it. WAVE1 restricts the rate of actin extension and couples actin networks to the membrane to drive protrusion. CRISPR knockout of WAVE1 and WAVE2 individually and together, leading-edge actin extension measurement, retrograde flow measurement Molecular biology of the cell High 32697617
2009 HSPC300 interacts with WAVE2 protein and its silencing results in WAVE2 degradation in vitro, indicating HSPC300 is required for WAVE2 stability within the complex. siRNA knockdown, Western blot of WAVE2 levels, Co-immunoprecipitation Lung cancer (Amsterdam, Netherlands) Low 19576655

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Abi1 is essential for the formation and activation of a WAVE2 signalling complex. Nature cell biology 341 15048123
2003 Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration. Developmental cell 263 14536061
2004 PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia. Nature cell biology 202 15107862
2006 The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation. Current biology : CB 196 16401421
2003 WAVE2 is required for directed cell migration and cardiovascular development. Nature 190 12879075
2005 Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation. Proceedings of the National Academy of Sciences of the United States of America 178 15657136
2003 WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. The EMBO journal 155 12853475
2011 ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex. Molecular cell 150 21419341
2006 Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac. The Journal of cell biology 136 16702231
2005 Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells. Oncogene 132 15608687
2003 IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena. Journal of cell science 113 12734400
2008 Cdk5 phosphorylation of WAVE2 regulates oligodendrocyte precursor cell migration through nonreceptor tyrosine kinase Fyn. The Journal of neuroscience : the official journal of the Society for Neuroscience 97 18701695
2010 Role of Abl kinase and the Wave2 signaling complex in HIV-1 entry at a post-hemifusion step. PLoS pathogens 92 20585556
2018 Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America 90 29760073
2008 The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1. The Journal of cell biology 84 18809728
2007 WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse. Molecular and cellular biology 84 17591693
2010 Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation. Molecular psychiatry 81 20531346
2013 MicroRNA-146a acts as a metastasis suppressor in gastric cancer by targeting WASF2. Cancer letters 79 23435376
2011 mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formation. The Journal of biological chemistry 77 22179776
2011 IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. The Journal of clinical investigation 74 21383498
2006 c-Abl interacts with the WAVE2 signaling complex to induce membrane ruffling and cell spreading. The Journal of biological chemistry 74 16899465
2007 Correlation between liver metastasis of the colocalization of actin-related protein 2 and 3 complex and WAVE2 in colorectal carcinoma. Cancer science 71 17459058
2008 Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2. Journal of cell science 68 18198193
2004 N-WASP and WAVE2 acting downstream of phosphatidylinositol 3-kinase are required for myogenic cell migration induced by hepatocyte growth factor. The Journal of biological chemistry 67 15496413
2005 A WAVE2-Abi1 complex mediates CSF-1-induced F-actin-rich membrane protrusions and migration in macrophages. Journal of cell science 66 16280551
2011 Essential role for Abi1 in embryonic survival and WAVE2 complex integrity. Proceedings of the National Academy of Sciences of the United States of America 63 21482783
2007 Rac interacts with Abi-1 and WAVE2 to promote an Arp2/3-dependent actin recruitment during chlamydial invasion. Cellular microbiology 59 17501982
2007 Phosphorylation of WAVE2 by MAP kinases regulates persistent cell migration and polarity. Journal of cell science 58 18032787
2014 Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens. The Journal of biological chemistry 56 24469447
2013 The antagonistic modulation of Arp2/3 activity by N-WASP, WAVE2 and PICK1 defines dynamic changes in astrocyte morphology. Journal of cell science 53 23843614
2005 WAVE2 signaling mediates invasion of polarized epithelial cells by Salmonella typhimurium. The Journal of biological chemistry 49 15929989
2012 Antioxidant dieckol downregulates the Rac1/ROS signaling pathway and inhibits Wiskott-Aldrich syndrome protein (WASP)-family verprolin-homologous protein 2 (WAVE2)-mediated invasive migration of B16 mouse melanoma cells. Molecules and cells 47 22441674
2011 WAVE2 regulates meiotic spindle stability, peripheral positioning and polar body emission in mouse oocytes. Cell cycle (Georgetown, Tex.) 45 21543895
2007 Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex. Journal of biochemistry 44 17202194
2008 WAVE2- and microtubule-dependent formation of long protrusions and invasion of cancer cells cultured on three-dimensional extracellular matrices. Cancer science 43 18795939
2009 Membrane transport of WAVE2 and lamellipodia formation require Pak1 that mediates phosphorylation and recruitment of stathmin/Op18 to Pak1-WAVE2-kinesin complex. Cellular signalling 41 19162178
2021 WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity. Science (New York, N.Y.) 40 33766857
2009 WAVE2 is regulated by multiple phosphorylation events within its VCA domain. Cell motility and the cytoskeleton 39 19012317
2001 Enhancement of branching efficiency by the actin filament-binding activity of N-WASP/WAVE2. Journal of cell science 38 11792818
2015 Involvement of the Rac1-IRSp53-Wave2-Arp2/3 Signaling Pathway in HIV-1 Gag Particle Release in CD4 T Cells. Journal of virology 35 26018170
2010 Overexpression of HER2 signaling to WAVE2-Arp2/3 complex activates MMP-independent migration in breast cancer. Breast cancer research and treatment 35 20419393
2007 The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery. Blood 35 17664349
2016 CD147 regulates cancer migration via direct interaction with Annexin A2 and DOCK3-β-catenin-WAVE2 signaling. Oncotarget 34 26716413
2018 Rac1/WAVE2 and Cdc42/N-WASP Participation in Actin-Dependent Host Cell Invasion by Extracellular Amastigotes of Trypanosoma cruzi. Frontiers in microbiology 31 29541069
2014 HIV-1 triggers WAVE2 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration. The Journal of biological chemistry 31 24415754
2011 WAVE2, N-WASP, and Mena facilitate cell invasion via phosphatidylinositol 3-kinase-dependent local accumulation of actin filaments. Journal of cellular biochemistry 31 21769917
2018 Mangiferin inhibits cell migration and invasion through Rac1/WAVE2 signalling in breast cancer. Cytotechnology 28 29455393
2016 Inhibition of the Rac1-WAVE2-Arp2/3 signaling pathway promotes radiosensitivity via downregulation of cofilin-1 in U251 human glioma cells. Molecular medicine reports 27 27052944
2008 Requirement of kinesin-mediated membrane transport of WAVE2 along microtubules for lamellipodia formation promoted by hepatocyte growth factor. Experimental cell research 27 18514191
2020 Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. JACC. Basic to translational science 26 32368696
2006 Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin. Genes to cells : devoted to molecular & cellular mechanisms 26 16483316
2015 The NESH/Abi-3-based WAVE2 complex is functionally distinct from the Abi-1-based WAVE2 complex. Cell communication and signaling : CCS 25 26428302
2021 The Role of WAVE2 Signaling in Cancer. Biomedicines 24 34572403
2017 SH3BP1-induced Rac-Wave2 pathway activation regulates cervical cancer cell migration, invasion, and chemoresistance to cisplatin. Journal of cellular biochemistry 24 28786507
2016 The Rho GTPase Rif signals through IRTKS, Eps8 and WAVE2 to generate dorsal membrane ruffles and filopodia. Journal of cell science 24 27278019
2020 WAVE1 and WAVE2 have distinct and overlapping roles in controlling actin assembly at the leading edge. Molecular biology of the cell 23 32697617
2016 SH3-domain binding protein 1 in the tumor microenvironment promotes hepatocellular carcinoma metastasis through WAVE2 pathway. Oncotarget 23 26933917
2021 Rac1/Wave2/Arp3 Pathway Mediates Rat Blood-Brain Barrier Dysfunction under Simulated Microgravity Based on Proteomics Strategy. International journal of molecular sciences 22 34068233
2010 WAVE2 forms a complex with PKA and is involved in PKA enhancement of membrane protrusions. The Journal of biological chemistry 22 21119216
2009 Metastatic potential of lung squamous cell carcinoma associated with HSPC300 through its interaction with WAVE2. Lung cancer (Amsterdam, Netherlands) 22 19576655
2015 PLCβ3 mediates cortactin interaction with WAVE2 in MCP1-induced actin polymerization and cell migration. Molecular biology of the cell 21 26490115
2014 WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site. The Journal of biological chemistry 21 25342748
2012 The Src substrate SKAP2 regulates actin assembly by interacting with WAVE2 and cortactin proteins. The Journal of biological chemistry 21 23161539
2001 Requirement of the basic region of N-WASP/WAVE2 for actin-based motility. Biochemical and biophysical research communications 21 11401525
2016 Role of Rac1/WAVE2 Signaling in Mediating the Inhibitory Effects of γ-Tocotrienol on Mammary Cancer Cell Migration and Invasion. Biological & pharmaceutical bulletin 20 27904039
2017 ABI3, a component of the WAVE2 complex, is potentially regulated by PI3K/AKT pathway. Oncotarget 19 28978070
2016 Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics. Science signaling 19 27095595
2021 Dragon's Blood Regulates Rac1-WAVE2-Arp2/3 Signaling Pathway to Protect Rat Intestinal Epithelial Barrier Dysfunction Induced by Simulated Microgravity. International journal of molecular sciences 18 33800361
2012 WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration. Cerebral cortex (New York, N.Y. : 1991) 17 22617848
2006 MRP-1/CD9 gene transduction regulates the actin cytoskeleton through the downregulation of WAVE2. Oncogene 17 16682943
2017 A conformational change within the WAVE2 complex regulates its degradation following cellular activation. Scientific reports 16 28332566
2018 The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow. Nature communications 15 29915352
2013 WAVE2 regulates epithelial morphology and cadherin isoform switching through regulation of Twist and Abl. PloS one 15 23691243
2010 Nonmuscle myosin IIA is required for lamellipodia formation through binding to WAVE2 and phosphatidylinositol 3,4,5-triphosphate. Biochemical and biophysical research communications 15 21184743
2009 The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells. Stem cells (Dayton, Ohio) 15 19415782
2022 Hypomethylation-mediated upregulation of the WASF2 promoter region correlates with poor clinical outcomes in hepatocellular carcinoma. Journal of experimental & clinical cancer research : CR 14 35477411
2017 Dicer suppresses cytoskeleton remodeling and tumorigenesis of colorectal epithelium by miR-324-5p mediated suppression of HMGXB3 and WASF-2. Oncotarget 14 28915552
2023 The WAVE2/miR-29/Integrin-β1 Oncogenic Signaling Axis Promotes Tumor Growth and Metastasis in Triple-negative Breast Cancer. Cancer research communications 12 36968231
2021 LRRK2 and WAVE2 regulate microglial-transition through distinct morphological phenotypes to induce neurotoxicity in a novel two-hit in vitro model of neurodegeneration. Journal of cellular physiology 12 34543438
2014 Down-regulation of WAVE2, WASP family verprolin-homologous protein 2, in gastric cancer indicates lymph node metastasis and cell migration. Anticancer research 12 24778020
2010 Directional control of WAVE2 membrane targeting by EB1 and phosphatidylinositol 3,4,5-triphosphate. Cellular signalling 12 19925864
2019 Orai1 Promotes Osteosarcoma Metastasis by Activating the Ras-Rac1-WAVE2 Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research 11 31796725
2017 SKAP2 regulates Arp2/3 complex for actin-mediated asymmetric cytokinesis by interacting with WAVE2 in mouse oocytes. Cell cycle (Georgetown, Tex.) 11 28933599
2023 Intelectin enhances the phagocytosis of macrophages via CDC42-WASF2-ARPC2 signaling axis in Megalobrama amblycephala. International journal of biological macromolecules 10 36907302
2022 WASF2 Serves as a Potential Biomarker and Therapeutic Target in Ovarian Cancer: A Pan-Cancer Analysis. Frontiers in oncology 9 35359421
2022 SKAP2 is downregulated in the villous tissues of patients with missed abortion and regulates growth and migration in trophoblasts through the WAVE2-ARP2/3 signaling pathway. Placenta 9 36126383
2012 WAVE2 Protein Complex Coupled to Membrane and Microtubules. Journal of oncology 9 22315597
2010 WAVE2 targeting to phosphatidylinositol 3,4,5-triphosphate mediated by insulin receptor substrate p53 through a complex with WAVE2. Cellular signalling 9 20621182
2024 Dragon's blood attenuates LPS-induced intestinal epithelial barrier dysfunction via upregulation of FAK-DOCK180-Rac1-WAVE2-Arp3 and downregulation of TLR4/NF-κB signaling pathways. Journal of natural medicines 8 39014275
2023 Mangiferin inhibits chronic stress-induced tumor growth in colorectal liver metastases via WAVE2 signaling pathway. Heliyon 8 36873506
2022 Dysregulation of TSP2-Rac1-WAVE2 axis in diabetic cells leads to cytoskeletal disorganization, increased cell stiffness, and dysfunction. Scientific reports 8 36577792
2022 Semen Ziziphi Spinosae attenuates blood-brain barrier dysfunction induced by lipopolysaccharide by targeting the FAK-DOCK180-Rac1-WAVE2-Arp3 signaling pathway. NPJ science of food 7 35655066
2015 Inhibition of invasion by glycogen synthase kinase-3 beta inhibitors through dysregulation of actin re-organisation via down-regulation of WAVE2. Biochemical and biophysical research communications 7 26116771
2020 WAVE2 Enhanced Hepatic Stellate Cells Activity in Colorectal Liver Metastases. Cancer management and research 6 32904432
2018 Tropomyosin-related kinase C (TrkC) enhances podocyte migration by ERK-mediated WAVE2 activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 6 29162704
2015 MiR-146a activates WAVE2 expression and enhances phagocytosis in lipopolysaccharide-stimulated RAW264.7 macrophages. American journal of translational research 6 26396677
2024 circ_WASF2 regulates ferroptosis by miR-634/ GPX4 signaling in pancreatic cancer. Discover oncology 5 38704809
2021 Abelson interactor 1 splice isoform-L plays an anti-oncogenic role in colorectal carcinoma through interactions with WAVE2 and full-length Abelson interactor 1. World journal of gastroenterology 4 33958846
2020 MicroRNA-1253 Regulation of WASF2 (WAVE2) and its Relevance to Racial Health Disparities. Genes 4 32443852
2023 WAVE2 Regulates Actin-Dependent Processes Induced by the B Cell Antigen Receptor and Integrins. Cells 3 38067132

Missed literature

Know a paper Affinage missed for WASF2? Flag it for the maintainers and the community.

No submissions yet.