Affinage

TRPC1

Short transient receptor potential channel 1 · UniProt P48995

Length
793 aa
Mass
91.2 kDa
Annotated
2026-06-10
100 papers in source corpus 35 papers cited in narrative 35 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 9/9 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TRPC1 is the founding mammalian member of the canonical transient receptor potential (TRPC) family, a non-voltage-gated, Ca2+-permeable cation channel subunit that functions as a regulator of store-operated and receptor-operated Ca2+ entry across many cell types (PMID:7568191). Its membrane topology positions hydrophobic region 7 as a re-entrant pore loop anchored by the cytosolic C-terminus (PMID:14707123). TRPC1 cannot form functional homomeric channels; instead it obligately heteromerizes with other TRPC subunits—TRPC3-7, with selective assembly into TRPC1/4/5 multimers in brain—via its N-terminal coiled-coil and defined C-terminal interaction regions, and only reaches the plasma membrane when co-expressed with TRPC4 or TRPC5 (PMID:22157757, PMID:28790178, PMID:27131740). Within these heteromers TRPC1 contributes to the channel pore, reduces Ca2+ permeability, and lowers PI(4,5)P2 sensitivity, thereby tuning channel gating (PMID:22157757, PMID:30755645). TRPC1 is converted from a receptor-operated to a store-operated channel by STIM1, which binds TRPC1 selectively through its ERM domain and gates it via a lysine-rich polybasic region, promoting TRPC1 insertion into lipid rafts at ER-PM junctions (PMID:16906149, PMID:18420269); in vascular smooth muscle this STIM1-TRPC1 association nucleates a Gαq/PLCβ1 complex whose PKC-mediated phosphorylation gates the channel (PMID:27753095). Channel activity is further modulated by PKCα phosphorylation downstream of thrombin (PMID:15016832), by direct PKG phosphorylation at Ser172/Thr313 (PMID:25139746), and by negative regulators including SARAF and the inhibitor I-mfa acting at a TRPC1ε–Orai1 complex (PMID:27506849, PMID:23770672). TRPC1 also assembles into distinct functional complexes with TRPP2 at the primary cilium, with TRPV4 (and KCa1.1) in endothelium and smooth muscle, and with caveolin-1/3 and IP3R3 for plasma-membrane targeting and store-release coupling (PMID:18323855, PMID:28867591, PMID:25139746, PMID:18544631, PMID:19052258). Through these channels, TRPC1-mediated Ca2+ entry drives diverse processes: myoblast migration, differentiation and regeneration via calpain and PI3K/Akt/mTOR signaling (PMID:19001499, PMID:22399301), maladaptive cardiac hypertrophy via calcineurin/NFAT/mTOR/Akt (PMID:19797170), VEGF-A-dependent angiogenesis through ERK (PMID:20185799), mGluR5-dependent hippocampal synaptic plasticity and spatial memory (PMID:30271326, PMID:28790178), and cancer cell proliferation through EGFR and CaM-PI3K amplification loops (PMID:22451676, PMID:34642309). TRPC1 is cleaved by caspase-11 and negatively regulates unconventional IL-1β secretion in macrophages (PMID:24630989), and is exploited by HSV-1 glycoprotein D, which binds its third ectodomain to facilitate viral entry (PMID:32206724).

Mechanistic history

Synthesis pass · year-by-year structured walk · 23 steps
  1. 1995 Medium

    Established the existence and identity of a mammalian TRP homolog, defining TRPC1 as a candidate non-voltage-gated plasma membrane Ca2+ channel and founding the TRPC family.

    Evidence Molecular cloning, sequence analysis, and expression profiling of the human TRP homolog

    PMID:7568191

    Open questions at the time
    • No direct electrophysiology demonstrating channel activity
    • Activation mechanism and partners unknown
  2. 2004 High

    Resolved how the polypeptide threads the membrane, defining the re-entrant pore loop and the C-terminal anchor required to form the conduction pathway.

    Evidence Truncation mutants plus N-glycosylation topology reporters in HEK-293T cells

    PMID:14707123

    Open questions at the time
    • No high-resolution structure
    • Topology in native heteromeric channels not addressed
  3. 2004 High

    Identified PKCα phosphorylation as a required gating input linking GPCR/store-depletion stimuli to TRPC1-dependent Ca2+ entry and endothelial permeability.

    Evidence Patch clamp, Ca2+ imaging, kinase-defective PKCα mutants, phosphorylation assays in endothelial cells

    PMID:15016832

    Open questions at the time
    • Phosphorylation sites not mapped
    • Direct vs indirect phosphorylation not resolved
  4. 2005 Medium

    Proposed TRPC1 as a constituent of the vertebrate mechanosensitive cation channel gated by bilayer tension.

    Evidence Liposome reconstitution + patch-clamp, heterologous overexpression and antisense knockdown in oocytes and CHO cells

    PMID:15665854

    Open questions at the time
    • Subsequently not replicated in COS/CHO cells (#5)
    • Whether TRPC1 alone confers mechanosensitivity disputed
  5. 2006 High

    Defined STIM1 as the store-sensor that activates TRPC1, mapping selective binding to the ERM domain and gating to a lysine-rich region.

    Evidence Reciprocal Co-IP, STIM1 siRNA, constitutively active and dominant-negative STIM1 mutants, electrophysiology in HEK293

    PMID:16906149

    Open questions at the time
    • Stoichiometry of STIM1-TRPC1 coupling unresolved
    • Role of Orai not addressed in this study
  6. 2007 Medium

    Directly challenged the simple TRPC1-as-MscCa model by showing overexpression does not augment mechanosensitive currents.

    Evidence Fast pressure-clamp patch-clamp of TRPC1/TRPC6-transfected COS/CHO cells with protein verification

    PMID:17957383

    Open questions at the time
    • Negative result; cell-type or partner dependence not excluded
    • Does not exclude TRPC1 in native mechanosensory complexes
  7. 2008 High

    Showed STIM1 converts TRPC1 from a receptor-operated to a store-operated channel by driving its insertion into lipid rafts, and defined caveolin-1/IP3R3 C-terminal interactions required for store-release coupling and PM targeting.

    Evidence TIRFM-FRET, lipid raft fractionation, domain-mapping mutagenesis, Co-IP and Ca2+ imaging in endothelial and Cav-1 KO cells

    PMID:18420269 PMID:19052258

    Open questions at the time
    • Dynamics of raft recruitment in vivo unclear
    • Interplay of STIM1 vs caveolin targeting not fully integrated
  8. 2008 High

    Demonstrated that TRPC1 forms functionally distinct heteromeric channels beyond the TRPC family, assembling with TRPP2 at the primary cilium with unique conductance and permeability.

    Evidence Heterologous electrophysiology, Co-IP from kidney membranes, gain/loss-of-function and ciliary immunolocalization

    PMID:18323855

    Open questions at the time
    • Physiological stimulus gating the ciliary complex unknown
    • Stoichiometry undetermined
  9. 2008 High

    Linked TRPC1 to skeletal muscle biology through caveolin-3-dependent membrane targeting and through SOCE-driven calpain activation controlling myoblast migration and fusion.

    Evidence FRET, Co-IP, ROS/Src pharmacology in mdx muscle; siRNA knockdown with calpain/MARCKS and migration readouts in primary myoblasts

    PMID:18544631 PMID:19001499

    Open questions at the time
    • Whether caveolin-3 and STIM1 pathways are mutually exclusive unresolved
    • Direct calpain regulation by Ca2+ flux vs other inputs not isolated
  10. 2008 Medium

    Established TRPC1 as a SOCE/migration component in vascular smooth muscle interacting with STIM1, while also contributing to proliferation independently of STIM1, and placed TRPC1-Ca2+ entry upstream of PP2A/NF-κB in epithelium.

    Evidence siRNA, Co-IP, extracellular antibody block and patch-clamp in VSMCs; stable TRPC1 expression with PP2A/NF-κB assays in IEC-6 cells

    PMID:18322138 PMID:18802022

    Open questions at the time
    • STIM1-independent proliferation mechanism undefined
    • Connection between channel gating and PP2A activation not mapped
  11. 2009 High

    Genetically established TRPC1 as a driver of maladaptive cardiac hypertrophy upstream of calcineurin/NFAT/mTOR/Akt, and proposed an SR Ca2+ leak function in skeletal muscle.

    Evidence Trpc1−/− mice with pressure overload, cardiomyocyte patch-clamp and signaling readouts; TRPC1-YFP localization and Ca2+ assays in muscle fibers

    PMID:19797170 PMID:19875453

    Open questions at the time
    • Plasma membrane vs SR localization debate unresolved (#13 vs prior models)
    • How the same subunit serves both compartments unclear
  12. 2010 High

    Demonstrated a cell-autonomous requirement for TRPC1 in VEGF-A-driven angiogenic sprouting via ERK signaling.

    Evidence Morpholino knockdown with mRNA rescue, cell transplantation, in vivo imaging and ERK phosphorylation assay in zebrafish

    PMID:20185799

    Open questions at the time
    • Channel partners in endothelial tip cells not identified
    • Direct link between Ca2+ flux and ERK activation not dissected
  13. 2011 High

    Established the core biophysical principle that TRPC1 is an obligate heteromeric subunit that contributes to the pore and reduces Ca2+ permeability, and defined native TRPC1/TRPC5 channels whose conductance and PKC/phosphoinositide regulation depend on TRPC1.

    Evidence Heteromer electrophysiology with pore-region mutagenesis; single-channel patch-clamp in WT vs TRPC1−/− VSMCs with PKC/PIP pharmacology

    PMID:21968068 PMID:22157757

    Open questions at the time
    • Subunit stoichiometry in native heteromers undetermined
    • Structural basis for permeability reduction unknown
  14. 2012 High

    Connected TRPC1-mediated Ca2+ entry to proliferative signaling, forming an EGFR amplification loop in lung carcinoma and acting upstream of PI3K/Akt/mTOR during muscle regeneration.

    Evidence siRNA with cell-cycle and phospho-EGFR readouts; Trpc1−/− cardiotoxin injury model with PI3K/Akt/myogenic factor readouts

    PMID:22399301 PMID:22451676

    Open questions at the time
    • Mechanism coupling channel Ca2+ to EGFR/PI3K not molecularly defined
    • Heteromeric partner in these contexts unidentified
  15. 2013 High

    Revealed a splice variant (TRPC1ε)–Orai1 complex amplifying CRAC activity and an antagonistic I-mfa input controlling osteoclastogenesis.

    Evidence TRPC1−/− and I-mfa−/− double-KO mice, osteoclast/bone resorption assays, electrophysiology, Co-IP of TRPC1ε–Orai1 in HEK293

    PMID:23770672

    Open questions at the time
    • Generality of TRPC1ε across tissues unknown
    • How I-mfa modulates the channel mechanistically unclear
  16. 2014 High

    Identified TRPC1 as a caspase-11 substrate that negatively restrains unconventional IL-1β secretion, and as a direct PKG phosphorylation target at Ser172/Thr313 within a TRPV4/KCa1.1 vascular complex.

    Evidence Caspase-11 substrate identification with trpc1−/− macrophages and sepsis model; in vitro PKG phosphorylation, Co-IP, and vascular tension assays

    PMID:24630989 PMID:25139746

    Open questions at the time
    • Cleavage site and functional consequence of caspase-11 processing not mapped
    • Link between phosphorylation and gating state not defined
  17. 2015 Medium

    Showed TRPC1-mediated Ca2+ entry promotes protective autophagy under hypoxia/nutrient stress, specific to TRPC1 over TRPC3.

    Evidence TRPC1 siRNA and overexpression with Ca2+ imaging, LC3B and apoptosis readouts in primary salivary gland cells

    PMID:25741599

    Open questions at the time
    • Downstream autophagy effectors of TRPC1-Ca2+ not identified
    • Single lab, single cell type
  18. 2016 High

    Mapped the structural determinants of TRPC1 heteromerization with TRPC4/5 and identified SARAF as a STIM1-independent negative regulator, while defining the STIM1-Gαq-PLCβ1 gating module in smooth muscle.

    Evidence FRET and truncation mapping of CCD/C-terminal interaction regions; Co-IP and Ca2+ assays for SARAF; patch-clamp, PLA, PIP2 imaging and TRPC1−/− VSMCs

    PMID:27131740 PMID:27506849 PMID:27753095

    Open questions at the time
    • Whether SARAF and STIM1 compete for TRPC1 unknown
    • Quantitative contribution of each regulatory input in vivo unclear
  19. 2017 High

    Defined the native brain channel composition (exclusive TRPC1/4/5 heteromers) and its role in synaptic transmission, memory, and muscle SOCE via preferential STIM1L coupling, plus a TRPV4-TRPC1 endothelial vasorelaxation channel.

    Evidence Quantitative MS of native complexes and Trpc1/4/5 triple-KO electrophysiology/behavior; siRNA and Co-IP in human myotubes; PLA and single-channel recording in artery endothelium

    PMID:28185894 PMID:28790178 PMID:28867591

    Open questions at the time
    • Subunit stoichiometry within native heteromers undetermined
    • How distinct partners (STIM1L vs TRPV4) select channel function unclear
  20. 2018 Medium

    Dissected the dual Gαq/PI(4,5)P2 regulatory logic of TRPC1/4 and TRPC1/5 channels, showing Gαq binds TRPC4/5 (not TRPC1) for activation while PLCβ-driven PIP2 depletion self-limits the current.

    Evidence Co-IP of Gαq with subunits, heteromer patch-clamp, DrVSP-based PI(4,5)P2 depletion

    PMID:30108272

    Open questions at the time
    • Physiological balance of activation vs inhibition not quantified
    • Role of TRPC1 in Gαq coupling beyond permeability tuning unclear
  21. 2019 Medium

    Defined TRPC1 as a negative modulator that lowers PI(4,5)P2 sensitivity of TRPC4/5 heteromers, mapping the PIP2 binding residues to TRPC4.

    Evidence DrVSP PI(4,5)P2 dephosphorylation with patch-clamp, PIP2-sensor FRET and neutralizing mutagenesis

    PMID:30755645

    Open questions at the time
    • TRPC1's own PIP2 contribution not isolated
    • Physiological consequence of equalized PIP2 affinity untested in vivo
  22. 2020 High

    Identified TRPC1 as a host entry factor for HSV-1 through direct binding of its third ectodomain by viral glycoprotein D.

    Evidence Co-IP of gD with TRPC1 ectodomain, knockdown/knockout viral entry assays, TRPC1−/− ocular model and human biopsy staining

    PMID:32206724

    Open questions at the time
    • Whether channel activity vs binding alone mediates entry not separated
    • Generality across other herpesviruses unknown
  23. 2021 Medium

    Connected TRPC1 to oncogenic signaling via direct calmodulin binding that bridges CaM to PI3K p85, activating PI3K/AKT and EMT in colorectal cancer.

    Evidence Co-IP of TRPC1-CaM and CaM-PI3K p85, siRNA/overexpression functional assays, Trpc1−/− CRC mouse model

    PMID:34642309

    Open questions at the time
    • Whether CaM binding requires channel Ca2+ flux unresolved
    • Single lab, mechanism of CaM-p85 bridging not structurally defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • The subunit stoichiometry, atomic structure, and rules governing how TRPC1's partner choice (TRPC4/5, TRPP2, TRPV4, Orai1) and regulatory inputs (STIM1, SARAF, PKC, PKG, caveolins) are integrated to specify channel gating and Ca2+ permeability in each tissue remain unresolved.
  • No high-resolution structure of any TRPC1-containing channel
  • Native heteromer stoichiometry undetermined
  • Integration of competing regulators not reconciled

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005215 transporter activity 4 GO:0140096 catalytic activity, acting on a protein 1
Localization
GO:0005886 plasma membrane 5 GO:0005783 endoplasmic reticulum 2 GO:0005929 cilium 1
Pathway
R-HSA-162582 Signal Transduction 4 R-HSA-1266738 Developmental Biology 3 R-HSA-8953897 Cellular responses to stimuli 2 R-HSA-168256 Immune System 1
Partners
CALM1CAV1CAV3ORAI1STIM1TRPC4TRPC5TRPV4
Complex memberships
TRPC1/TRPC4/TRPC5 heterotetramerTRPC1/TRPP2 channelTRPC1ε/Orai1 CRAC complexTRPV4/TRPC1/KCa1.1 complex

Evidence

Reading pass · 35 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 TRPC1 was cloned as a human homolog of Drosophila TRP, predicted to be a non-voltage-gated plasma membrane Ca2+ channel (lacks charged residues in S4 proposed for voltage sensing), and identified as the founding member of the mammalian TRPC family. Molecular cloning, sequence analysis, expression profiling Proceedings of the National Academy of Sciences of the United States of America Medium 7568191
2004 Biogenesis and transmembrane topology of human TRPC1 was determined: hydrophobic regions (HRs) 1, 4, and 6 cross the membrane cytosol-to-ER lumen; HRs 2, 5, and 8 have opposite orientation; HR 3 remains cytosolic; HR 7 forms a pore-like re-entrant loop. The C-terminal sequence downstream of HR 8 anchors the cytosolic end and prevents HR 7 from fully spanning the bilayer, creating the channel pore. Truncation mutant approach combined with N-linked glycosylation site insertions in HEK-293T cells; glycosylation used as lumenal topology reporter The Journal of biological chemistry High 14707123
2004 PKCα phosphorylates TRPC1 in human endothelial cells downstream of thrombin or thapsigargin stimulation, and this phosphorylation is required for store-operated Ca2+ entry and the resulting increase in endothelial permeability. Genetic or pharmacological inhibition of PKCα blocked IP3-induced cationic current and Ca2+ entry, and thrombin failed to phosphorylate TRPC1 when PKCα was inactive. Whole-cell patch clamp, Fura-2 Ca2+ imaging, kinase-defective PKCα mutants, pharmacological inhibition (Gö6976), TRPC1-specific extracellular antibody block, phosphorylation assays, transendothelial resistance The Journal of biological chemistry High 15016832
2005 TRPC1 protein was identified as a component of the vertebrate mechanosensitive cation channel (MscCa): purification of frog oocyte membrane proteins followed by liposome reconstitution and patch-clamp identified an ~80 kDa protein as TRPC1 by immunological methods. Heterologous expression of human TRPC1 in oocytes increased MscCa patch density >1000%, and TRPC1-specific antisense RNA abolished endogenous MscCa activity. Transfection into CHO-K1 cells also increased MscCa expression. The channel is gated by tension in the lipid bilayer. Detergent solubilization + liposome reconstitution + patch-clamp; immunological identification; heterologous overexpression; antisense RNA knockdown; CHO-K1 transfection Nature cell biology Medium 15665854
2006 The cytosolic C-terminus of STIM1 is sufficient to activate TRPC1 channels. STIM1 binds TRPC1, TRPC2, and TRPC4 selectively (not TRPC3, 6, or 7) via its ERM domain, and gates TRPC1 through a cationic lysine-rich region. Deletion of either domain in constitutively active STIM1(D76A) produces dominant-negative mutants that block native SOC and TRPC1 channel activity. Co-immunoprecipitation, siRNA knockdown of STIM1, constitutively active and dominant-negative STIM1 mutants expressed in HEK293 cells, electrophysiology, Ca2+ imaging Nature cell biology High 16906149
2007 Overexpression of TRPC1 or TRPC6 in COS or CHO cells did not significantly alter the amplitude of mechanosensitive currents measured with a fast pressure clamp, contradicting a simple model in which TRPC1 alone forms the vertebrate MscCa. Transient transfection of TRPC1 or TRPC6 in COS/CHO cells; fast pressure-clamp patch-clamp recordings; Western blot confirmation of protein expression Pflugers Archiv : European journal of physiology Medium 17957383
2008 TRPC1 and caveolin-3 co-localize and co-immunoprecipitate in muscle cells; direct binding was confirmed by FRET between TRPC1-CFP and caveolin-3-YFP in C2 myoblasts. Caveolin-3 targeted TRPC1 to the plasma membrane. ROS increased Src kinase activity and enhanced Ca2+ influx only in cells co-expressing TRPC1 and caveolin-3, revealing a ROS–Src–TRPC1/caveolin-3 pathway in Duchenne muscular dystrophy pathogenesis. Co-immunoprecipitation, FRET, confocal microscopy, Src inhibitor PP2, ROS scavenger Tiron, Ca2+ influx measurements in mdx muscle Journal of cell science High 18544631
2008 TRPP2 and TRPC1 assemble into a heteromeric receptor-operated channel with unique properties distinct from either subunit alone: different single-channel conductance, amiloride sensitivity, and ion permeability. Native TRPP2/TRPC1 channel activity was demonstrated in kidney cells by gain- and loss-of-function experiments; the complex co-localizes at the primary cilium and co-immunoprecipitates from kidney membranes. Heterologous expression, electrophysiology, co-immunoprecipitation from kidney membranes, gain/loss-of-function in kidney cells, immunolocalization to primary cilium EMBO reports High 18323855
2008 STIM1 association converts TRPC1 from a receptor-operated channel (ROC) to a store-operated channel (SOC) by promoting insertion of TRPC1 into lipid rafts. In the absence of STIM1, TRPC1 associates with other TRPC members to form ROCs. TIRFM-FRET demonstrated the dynamic association between STIM1 and TRPC1 at ER-PM junctions and lipid rafts. TIRFM-FRET, lipid raft fractionation, co-immunoprecipitation, Ca2+ imaging, siRNA knockdown of STIM1 Cell calcium Medium 18420269
2008 Caveolin-1 scaffold domain (CSD, residues 82–101) directly interacts with TRPC1 C-terminal residues 781–789 and also with IP3R3. The TRPC1-CΔ781-789 mutant abolishes Ca2+ store release-induced Ca2+ influx and disrupts binding to both IP3R3 and caveolin-1. Caveolin-1ΔCSD shows gain-of-function Ca2+ entry. WT caveolin-1 but not ΔCSD interacts with IP3R3 and TRPC1. Co-immunoprecipitation, deletion mutagenesis of TRPC1 C-terminus and CSD, Ca2+ imaging, Fura-2, confocal co-localization, Cav-1 KO mouse lung endothelial cells American journal of physiology. Cell physiology High 19052258
2008 STIM1 and TRPC1 interact in vascular smooth muscle cells (VSMCs); TRPC1 contributes to a component of store-operated cation current and cell migration. Extracellular STIM1 N-terminus was detected, and extracellular STIM1 antibody rapidly inhibited store-depletion-evoked current. TRPC1-containing channels also contributed to cell proliferation independently of STIM1. siRNA knockdown of STIM1 and TRPC1, co-immunoprecipitation, extracellular antibody block, patch-clamp, Fura-2 Ca2+ imaging, cell migration and proliferation assays, cell surface localization studies Circulation research Medium 18802022
2008 TRPC1 depletion in skeletal myoblasts reduces store-operated Ca2+ entry and abolishes the transient calpain activity peak at the onset of differentiation. This leads to accumulation of the calpain substrate MARCKS, slowed cell migration, and impaired myotube fusion. IGF-1-stimulated migration and calpain activation were also dependent on TRPC1 expression. siRNA knockdown of TRPC1 in primary myoblasts, Ca2+ imaging, calpain activity assay, immunofluorescence for MARCKS, time-lapse migration assay, GsMTx4 and calpain inhibitor pharmacology Journal of cell science High 19001499
2009 TRPC1 knockout mice lack the TRPC-associated non-selective cation current observed after pressure overload and are protected from maladaptive cardiac hypertrophy. Mechanosensitive signaling through calcineurin/NFAT, mTOR, and Akt is altered in Trpc1−/− mice subjected to hemodynamic stress, placing TRPC1 upstream of these hypertrophic pathways. Trpc1−/− mouse model, pressure overload (transverse aortic constriction), whole-cell patch-clamp of cardiomyocytes, cardiac function measurements, Western blot/immunostaining for calcineurin/NFAT/mTOR/Akt Circulation research High 19797170
2009 TRPC1 operates as a Ca2+ leak channel in the sarcoplasmic reticulum (SR) of skeletal muscle fibers, not at the sarcolemma as previously proposed. Immunostaining colocalizes TRPC1-YFP with SR Ca2+ pump markers in a striated pattern. Overexpression increases resting SR Ca2+, accelerates CPA-induced Ca2+ rise, and slows Ca2+ transient decay, all consistent with SR Ca2+ leak function. TRPC1-YFP overexpression in adult mouse muscle fibers, immunostaining, Ca2+ measurements (Fluo-4), CPA-induced contracture assay, voltage-clamp Ca2+ transients The Journal of biological chemistry Medium 19875453
2010 TRPC1 is required for angiogenesis in zebrafish: morpholino knockdown of trpc1 severely disrupts intersegmental vessel sprouting in an endothelial-cell-autonomous manner, impairing filopodial extension, tip-cell migration and proliferation. TRPC1 acts downstream of Vegf-a and is required for Vegf-a-induced ERK phosphorylation. Antisense morpholino knockdown, rescue with morpholino-resistant trpc1 mRNA, cell transplantation, in vivo time-lapse imaging, Vegf-a interaction experiments, ERK phosphorylation assay Circulation research High 20185799
2011 Recombinant TRPC1 subunits do not form functional homomeric channels; instead they form functional heteromeric receptor-operated channels with all other TRPC subfamily members (TRPC3, 4, 5, 6, 7). In all TRPC1-containing heteromers, TRPC1 significantly reduces calcium permeability. Pore-region amino acid substitutions in TRPC1 further reduce Ca2+ permeability, confirming TRPC1 contributes to the channel pore. Electrophysiology of heterologously expressed TRPC1 homomers and heteromers, pore-region mutagenesis, Ca2+ permeability measurements, TRPC1 siRNA in GnRH neurons The Journal of biological chemistry High 22157757
2011 In vascular smooth muscle cells (VSMCs), store depletion activates native heteromeric TRPC1/TRPC5 channels (~2 pS conductance, activated by PKC, PIP2, and PIP3). In TRPC1−/− VSMCs, TRPC5 homomeric channels (with multiple subconductance states 14/32/53 pS) form instead and show opposite regulation (inhibited by PKC, PIP2, PIP3; activated by elevated [Ca2+]i). TRPC1 determines unitary conductance and confers PKC/phosphoinositide activation. Single-channel patch-clamp in acutely isolated mesenteric artery VSMCs from WT and TRPC1−/− mice, co-immunoprecipitation, anti-TRPC antibody blocking, PKC activator/inhibitor pharmacology, PIP2/PIP3 application FASEB journal High 21968068
2012 TRPC1 depletion in non-small cell lung carcinoma cells causes G0/G1 arrest, reduces cyclin D1/D3, and decreases EGFR phosphorylation with disruption of PI3K/Akt and MAPK signaling. EGF stimulation triggers Ca2+ release and Ca2+ entry through TRPC1, and this Ca2+ entry reciprocally activates EGFR, forming a Ca2+-dependent amplification loop for EGF-dependent proliferation. siRNA knockdown of TRPC1, cell cycle analysis, Western blot for cyclins and phospho-EGFR, EGF stimulation with Ca2+ imaging The Journal of biological chemistry Medium 22451676
2012 Trpc1−/− mice show impaired PI3K/Akt/mTOR/p70S6K signaling during muscle regeneration. Trpc1 KO primary myoblasts and regenerating muscles have reduced Akt phosphorylation, decreased MyoD/Myf5/myogenin expression, smaller fiber size, and delayed regeneration after cardiotoxin injury. Ca2+ entry through Trpc1 enhances PI3K activity, placing Trpc1 upstream of the PI3K/Akt pathway in myogenesis. Trpc1−/− mouse, cardiotoxin muscle injury model, primary myoblast culture, Western blot for PI3K/Akt/p70S6K/myogenic factors, EGTA-AM and wortmannin pharmacology The Journal of biological chemistry High 22399301
2013 TRPC1 and I-mfa (inhibitor of MyoD family) antagonistically regulate osteoclastogenesis. A new splice variant TRPC1ε uniquely amplifies CRAC channel activity and physically interacts with Orai1 (pore-forming CRAC subunit). I-mfa is recruited to the TRPC1ε–Orai1 complex through TRPC1ε and suppresses CRAC activity, revealing a positive/negative modulation axis. TRPC1−/− and I-mfa−/− double-KO mice, in vitro osteoclast differentiation, bone resorption assays, whole-cell electrophysiology, co-immunoprecipitation of TRPC1ε–Orai1 complex, heterologous expression of TRPC1ε in HEK293 The Journal of biological chemistry High 23770672
2014 Caspase-11 cleaves/degrades TRPC1 as a substrate. TRPC1 deficiency increases IL-1β secretion without altering caspase-1 cleavage or cell death in macrophages, and trpc1−/− mice show higher IL-1β in a sepsis model, indicating TRPC1 negatively regulates unconventional IL-1β secretion downstream of caspase-11 independently of caspase-1. Identification of TRPC1 as caspase-11 substrate, trpc1−/− macrophages and mice, LPS-induced sepsis model, IL-1β ELISA, caspase-1 cleavage assay Cell reports High 24630989
2016 SARAF (SOCE-associated regulatory factor) interacts with TRPC1 independently of STIM1 and negatively regulates TRPC1-mediated Ca2+ entry. This interaction is enhanced by agonist (ATP) stimulation. In contrast, SARAF–TRPC6 interaction is constitutive and SARAF does not regulate TRPC6-mediated Ca2+ entry. Co-immunoprecipitation in STIM1-deficient NG115-401L cells and STIM1-expressing SH-SY5Y cells, SARAF siRNA, Ca2+ entry measurements, TRPC6 overexpression cells The Biochemical journal Medium 27506849
2016 Store-operated STIM1–TRPC1 interactions in VSMCs stimulate PLCβ1 activity and PKC phosphorylation of TRPC1 to induce channel gating. Store depletion causes STIM1 translocation to the plasma membrane where it forms complexes with TRPC1, Gαq, and PLCβ1. TRPC1-based SOC activity and store-operated PLCβ1 activity are absent in TRPC1−/− VSMCs. Patch-clamp, GFP-PLCδ1-PH imaging for PLCβ1 activity, co-immunoprecipitation, proximity ligation assays, STIM1 shRNA, TRPC1−/− VSMCs, immunocytochemistry The Journal of physiology High 27753095
2017 TRPC1, TRPC4, and TRPC5 assemble exclusively into heteromultimers with each other (not other TRP family members) in mouse brain and hippocampus, as determined by quantitative mass spectrometry. In Trpc1/4/5 triple-KO hippocampal neurons, action potential-triggered EPSCs are reduced while miniature EPSC frequency/amplitude are unchanged, and spatial working memory and flexible relearning are impaired in vivo. Quantitative high-resolution mass spectrometry of native complexes, Trpc1/4/5 triple-KO mice, whole-cell patch-clamp of hippocampal neurons, hippocampal slice recordings, in vivo behavioral testing The EMBO journal High 28790178
2017 TRPC1 and TRPC4 functionally interact preferentially with STIM1L (muscle-specific long isoform) compared to canonical STIM1 in human myotubes. Knockdown of TRPC1 or TRPC4 reduces SOCE by ~50%, delays Ca2+ entry onset, and impairs myotube formation—effects similar to STIM1L invalidation. siRNA knockdown of TRPC1, TRPC4, and STIM1L in human myotubes, Co-immunoprecipitation on store depletion, Ca2+ imaging (Fluo-4), myotube size quantification Biochimica et biophysica acta. Molecular cell research Medium 28185894
2017 Heteromeric TRPV4–TRPC1 channels mediate calcium-sensing receptor (CaSR)-induced NO production and vasorelaxation in rabbit mesenteric artery endothelial cells. TRPV4 and TRPC1 co-localize and are in proximity at the plasma membrane of endothelial cells. A TRPV4 agonist activates 6 pS cation channels blocked by both TRPV4 antagonists and TRPC1 extracellular antibody. Proximity ligation assay, immunocytochemistry, wire myography, DAF-FM NO fluorescence, perforated-patch electrophysiology, pharmacological antagonists (RN1734, HC067047) and TRPC1 antibody (T1E3) Vascular pharmacology Medium 28867591
2018 Gαq protein directly interacts with TRPC4 or TRPC5 subunits (not TRPC1) in TRPC1/4 and TRPC1/5 heterotetramers to permit activation by the Gαq-PLCβ pathway. Simultaneously, PLCβ-driven PI(4,5)P2 depletion inhibits TRPC1/4 and TRPC1/5 channel activity, creating a self-limited dual regulatory mechanism. Co-immunoprecipitation of Gαq with TRPC subunits, patch-clamp electrophysiology of heteromeric channels, DrVSP-based PI(4,5)P2 depletion, pharmacological activation of Gαq Scientific reports Medium 30108272
2018 mGluR5 activation specifically activates TRPC1-containing channels in hippocampal CA1-3 neurons. Trpc1−/− mice show impaired mGluR-induced synaptic excitability, defective LTP maintenance, impaired mGluR-LTD, and altered spatial working memory. Acute inhibition with Pico145 mimics genetic TRPC1 depletion, excluding developmental compensation. Trpc1−/− mice, whole-cell patch-clamp, LTP and LTD recordings in hippocampal slices, mGluR5 activation, Pico145 pharmacology, behavioral testing (Morris water maze, fear conditioning) Frontiers in cellular neuroscience High 30271326
2020 HSV-1 glycoprotein D interacts with the third ectodomain of TRPC1, facilitating viral entry into cells. TRPC1 knockout attenuates HSV-1-induced Ca2+ entry, viral infection, and ocular pathology in vivo. HSV-1 infection correlates with plasma membrane localization of TRPC1 in oral lesion epithelial cells. Co-immunoprecipitation of gD with TRPC1 ectodomain, TRPC1 knockdown/knockout, Ca2+ imaging, viral entry/infection assays, TRPC1−/− mouse ocular model, human biopsy immunostaining Science advances High 32206724
2021 TRPC1 directly binds calmodulin (CaM) and enhances the interaction between CaM and the PI3K p85 subunit, thereby activating the PI3K/AKT and downstream signaling pathways involved in cell cycle progression and EMT in colorectal cancer cells. Silencing of CaM abolishes the oncogenic effects of TRPC1. Co-immunoprecipitation of TRPC1-CaM and CaM-PI3K p85, siRNA knockdown of TRPC1 and CaM, TRPC1 overexpression, proliferation/invasion/migration assays, Trpc1−/− mouse CRC model Oncogenesis Medium 34642309
2016 TRPC1 interaction domains for heteromerization with TRPC4 and TRPC5 were mapped: TRPC1's N-terminal coiled-coil domain (CCD) and C-terminal 725–745 region interact with TRPC4's N-terminal CCD and C-terminal 700–728 region; TRPC1's N-terminal CCD and C-terminal 673–725 region interact with TRPC5's N-terminal CCD and C-terminal 707–735 region. TRPC1 only reaches the plasma membrane when co-expressed with TRPC4 or TRPC5. FRET, patch-clamp electrophysiology, truncation/deletion mutants of TRPC1, TRPC4, and TRPC5 Biochemical and biophysical research communications Medium 27131740
2019 TRPC1 acts as a negative regulator of TRPC4 and TRPC5 channel activity: incorporation of TRPC1 into TRPC1/4 or TRPC1/5 heterotetramers reduces PI(4,5)P2 sensitivity compared to TRPC4 or TRPC5 homotetramers. PI(4,5)P2 binding sites were mapped to specific basic residues (K419, K664/R511, K518, H630) in TRPC4; TRPC1 equalizes PI(4,5)P2 affinity across heteromers. DrVSP-based PI(4,5)P2 dephosphorylation combined with patch-clamp, FRET to PI(4,5)P2 sensor, neutralizing mutagenesis of PI(4,5)P2 binding residues Scientific reports Medium 30755645
2014 Induced TRPC1 expression in intestinal epithelial cells increases protein phosphatase 2A (PP2A) activity through Ca2+ influx. Elevated PP2A reduces nuclear NF-κB levels and transcriptional activity, sensitizing cells to TNF-α/cycloheximide-induced apoptosis. Inhibition of PP2A or Ca2+ removal reverses these effects, placing TRPC1-mediated Ca2+ entry upstream of PP2A and NF-κB. Stable TRPC1 transfection in IEC-6 cells, PP2A activity assay, PP2A siRNA, okadaic acid, NF-κB reporter assay, apoptosis assay, Ca2+-free medium American journal of physiology. Cell physiology Medium 18322138
2014 PKG phosphorylates TRPC1 directly at Ser172 and Thr313. NO–cGMP–PKG pathway inhibits 11,12-EET-induced smooth muscle hyperpolarization and vascular relaxation via PKG-mediated phosphorylation of TRPC1. TRPV4, TRPC1, and KCa1.1 physically associate with each other in smooth muscle cells and TRPC1 inhibition abolishes EET responses. In vitro PKG phosphorylation assay of TRPC1 peptides, TAT-linked phosphorylation-site peptides (competitive inhibition), co-immunoprecipitation of TRPV4–TRPC1–KCa1.1 complex, membrane potential and arterial tension measurements Cardiovascular research High 25139746
2015 TRPC1-mediated Ca2+ entry regulates hypoxia- and nutrient-depletion-induced autophagy to prevent cell death. Hypoxia increases TRPC1 expression and Ca2+ entry through TRPC1. Silencing of TRPC1 reduces Ca2+ influx, decreases autophagic markers, and increases apoptosis. Notably, this effect is specific to TRPC1 and not TRPC3. TRPC1 siRNA, TRPC1 overexpression, Ca2+ imaging, autophagy markers (LC3B), apoptosis assays, primary salivary gland cells under hypoxia Cell death & disease Medium 25741599

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nature cell biology 541 16906149
1995 TRPC1, a human homolog of a Drosophila store-operated channel. Proceedings of the National Academy of Sciences of the United States of America 510 7568191
2005 TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nature cell biology 484 15665854
2007 Revisiting TRPC1 and TRPC6 mechanosensitivity. Pflugers Archiv : European journal of physiology 219 17957383
2016 TRPC1, Orai1, and STIM1 in SOCE: Friends in tight spaces. Cell calcium 187 28089266
2007 TRPC1: the link between functionally distinct store-operated calcium channels. Cell calcium 183 17350680
2009 TRPC1 channels are critical for hypertrophic signaling in the heart. Circulation research 174 19797170
2009 TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. The Journal of neuroscience : the official journal of the Society for Neuroscience 172 19439599
2006 Upregulation of TRPC1 in the development of cardiac hypertrophy. Journal of molecular and cellular cardiology 164 17174323
2004 Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells. The Journal of biological chemistry 149 15016832
2008 TRPC1 binds to caveolin-3 and is regulated by Src kinase - role in Duchenne muscular dystrophy. Journal of cell science 135 18544631
2005 TRPC1: store-operated channel and more. Pflugers Archiv : European journal of physiology 134 15965706
2008 Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits. EMBO reports 133 18323855
2004 Tumor necrosis factor-alpha-induced TRPC1 expression amplifies store-operated Ca2+ influx and endothelial permeability. American journal of physiology. Lung cellular and molecular physiology 131 15347566
2008 TRPC1 regulates skeletal myoblast migration and differentiation. Journal of cell science 128 19001499
2011 Transient receptor potential channel 1 (TRPC1) reduces calcium permeability in heteromeric channel complexes. The Journal of biological chemistry 123 22157757
2003 TRPC1 store-operated cationic channel subunit. Cell calcium 114 12765688
2012 Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Molecular pharmacology 110 23188715
2017 Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory. The EMBO journal 109 28790178
2008 STIM1 converts TRPC1 from a receptor-operated to a store-operated channel: moving TRPC1 in and out of lipid rafts. Cell calcium 108 18420269
2008 Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells. American journal of physiology. Cell physiology 99 19052258
2017 Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels. The Journal of biological chemistry 97 28325835
2004 TRPC1-mediated inhibition of 1-methyl-4-phenylpyridinium ion neurotoxicity in human SH-SY5Y neuroblastoma cells. The Journal of biological chemistry 89 15542611
2010 TRPC1 is essential for in vivo angiogenesis in zebrafish. Circulation research 88 20185799
2014 Caspase-11 controls interleukin-1β release through degradation of TRPC1. Cell reports 84 24630989
2012 TRPC1 protein channel is major regulator of epidermal growth factor receptor signaling. The Journal of biological chemistry 81 22451676
2017 TRPC1 is a differential regulator of hypoxia-mediated events and Akt signalling in PTEN-deficient breast cancer cells. Journal of cell science 80 28559303
2008 Interactions, functions, and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells. Circulation research 79 18802022
2011 Contribution of TRPC1 and Orai1 to Ca(2+) entry activated by store depletion. Advances in experimental medicine and biology 75 21290310
2008 TRPC1 channels regulate directionality of migrating cells. Pflugers Archiv : European journal of physiology 72 18542994
2014 Classical Transient Receptor Potential 1 (TRPC1): Channel or Channel Regulator? Cells 71 25268281
2009 TRPC1 inhibits apoptotic cell degeneration induced by dopaminergic neurotoxin MPTP/MPP(+). Cell calcium 70 19695701
2012 Trpc1 ion channel modulates phosphatidylinositol 3-kinase/Akt pathway during myoblast differentiation and muscle regeneration. The Journal of biological chemistry 66 22399301
2007 TRPC1 Ca(2+)-permeable channels in animal cells. Handbook of experimental pharmacology 66 17217049
2020 The Role of TRPC1 in Modulating Cancer Progression. Cells 65 32046188
2018 Ca2+ handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy. Journal of molecular and cellular cardiology 65 29634917
2007 TRPC1: a core component of store-operated calcium channels. Biochemical Society transactions 65 17233611
2013 A TRPC1 protein-dependent pathway regulates osteoclast formation and function. The Journal of biological chemistry 58 23770672
2018 Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory. Frontiers in cellular neuroscience 57 30271326
2011 The dynamic complexity of the TRPC1 channelosome. Channels (Austin, Tex.) 53 21747233
2016 CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes. Cellular & molecular immunology 50 27499044
2009 Glucose enhances expression of TRPC1 and calcium entry in endothelial cells. American journal of physiology. Heart and circulatory physiology 46 19855058
2005 Distribution of TRPC1 and TRPC5 in medial temporal lobe structures of mice. Cell and tissue research 45 16044320
2017 TRPC1 and TRPC4 channels functionally interact with STIM1L to promote myogenesis and maintain fast repetitive Ca2+ release in human myotubes. Biochimica et biophysica acta. Molecular cell research 44 28185894
2011 TRPC1 proteins confer PKC and phosphoinositol activation on native heteromeric TRPC1/C5 channels in vascular smooth muscle: comparative study of wild-type and TRPC1-/- mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 44 21968068
2009 TRPC1 is regulated by caveolin-1 and is involved in oxidized LDL-induced apoptosis of vascular smooth muscle cells. Journal of cellular and molecular medicine 44 20187291
2009 Transient receptor potential canonical type 1 (TRPC1) operates as a sarcoplasmic reticulum calcium leak channel in skeletal muscle. The Journal of biological chemistry 43 19875453
2017 Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced nitric oxide production and vasorelaxation in rabbit mesenteric arteries. Vascular pharmacology 42 28867591
2014 TRPC1. Handbook of experimental pharmacology 42 24756701
2016 TRPC1-STIM1 activation modulates transforming growth factor β-induced epithelial-to-mesenchymal transition. Oncotarget 41 27793015
2012 TRPC1 and Orai1 interact with STIM1 and mediate capacitative Ca(2+) entry caused by acute hypoxia in mouse pulmonary arterial smooth muscle cells. American journal of physiology. Cell physiology 41 23034388
2010 Functional interaction between TRPC1 channel and connexin-43 protein: a novel pathway underlying S1P action on skeletal myogenesis. Cellular and molecular life sciences : CMLS 41 20614160
2016 Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells. Cell calcium 39 27638096
2019 Role of TRPC1 channels in pressure-mediated activation of airway remodeling. Respiratory research 38 31092255
2015 TRPC1-mediated Ca²⁺ entry is essential for the regulation of hypoxia and nutrient depletion-dependent autophagy. Cell death & disease 37 25741599
2012 Role of TRPC1 and TRPC3 channels in contraction and relaxation of mouse thoracic aorta. Journal of vascular research 37 23095462
2018 Dual action of the Gαq-PLCβ-PI(4,5)P2 pathway on TRPC1/4 and TRPC1/5 heterotetramers. Scientific reports 35 30108272
2019 TRPC1 and ORAI1 channels in colon cancer. Cell calcium 34 31203007
2008 Evaluation of genetic association and expression reduction of TRPC1 in the development of diabetic nephropathy. American journal of nephrology 34 18802326
2019 TRPC1 as a negative regulator for TRPC4 and TRPC5 channels. Pflugers Archiv : European journal of physiology 33 31222490
2023 The Molecular Heterogeneity of Store-Operated Ca2+ Entry in Vascular Endothelial Cells: The Different roles of Orai1 and TRPC1/TRPC4 Channels in the Transition from Ca2+-Selective to Non-Selective Cation Currents. International journal of molecular sciences 32 36834672
2016 Store-operated interactions between plasmalemmal STIM1 and TRPC1 proteins stimulate PLCβ1 to induce TRPC1 channel activation in vascular smooth muscle cells. The Journal of physiology 32 27753095
2011 Upregulated TRPC3 and Downregulated TRPC1 Channel Expression during Hypertension is Associated with Increased Vascular Contractility in Rat. Frontiers in physiology 32 21811471
2018 Dopaminergic neurotoxins induce cell death by attenuating NF-κB-mediated regulation of TRPC1 expression and autophagy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 31 29150520
2017 TRPC1 stimulates calcium‑sensing receptor‑induced store‑operated Ca2+ entry and nitric oxide production in endothelial cells. Molecular medicine reports 30 28791397
2015 The contribution of TRPC1, TRPC3, TRPC5 and TRPC6 to touch and hearing. Neuroscience letters 29 26520460
2007 Store-operated Orai1 and IP3 receptor-operated TRPC1 channel. Channels (Austin, Tex.) 29 18711860
2022 TRPV4 and TRPC1 channels mediate the response to tensile strain in mouse Müller cells. Cell calcium 28 35398674
2021 TRPC1 promotes the genesis and progression of colorectal cancer via activating CaM-mediated PI3K/AKT signaling axis. Oncogenesis 28 34642309
2019 Loss of Ca2+ entry via Orai-TRPC1 induces ER stress, initiating immune activation in macrophages. Journal of cell science 28 31722977
2015 Molecular determinants of TRPC1 regulation within ER-PM junctions. Cell calcium 28 25922260
2008 Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death. Neuroscience letters 28 18822346
2009 TRPC1 expression and distribution in rat hearts. European journal of histochemistry : EJH 27 22073358
2004 Biogenesis and topology of the transient receptor potential Ca2+ channel TRPC1. The Journal of biological chemistry 27 14707123
2020 TRPC1 participates in the HSV-1 infection process by facilitating viral entry. Science advances 26 32206724
2020 TRPC1 exacerbate metastasis in gastric cancer via ciRS-7/miR-135a-5p/TRPC1 axis. Biochemical and biophysical research communications 26 32560824
2017 TRPC1- and TRPC3-dependent Ca2+ signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo. Glia 26 28636132
2015 Silencing of TRPC1 regulates store-operated calcium entry and proliferation in Huh7 hepatocellular carcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 26 25960236
2014 Nitric oxide and protein kinase G act on TRPC1 to inhibit 11,12-EET-induced vascular relaxation. Cardiovascular research 26 25139746
2014 Caveolin-1 enhances rapid mucosal restitution by activating TRPC1-mediated Ca2+ signaling. Physiological reports 26 25367694
2011 TRPC1, STIM1, and ORAI influence signal-regulated intracellular and endoplasmic reticulum calcium dynamics in human myometrial cells. Biology of reproduction 26 21565997
2016 SARAF modulates TRPC1, but not TRPC6, channel function in a STIM1-independent manner. The Biochemical journal 25 27506849
2013 TRPC1 protects dopaminergic SH-SY5Y cells from MPP+, salsolinol, and N-methyl-(R)-salsolinol-induced cytotoxicity. Acta biochimica et biophysica Sinica 25 24252728
2020 TRPC1/4/5 channels contribute to morphine-induced analgesic tolerance and hyperalgesia by enhancing spinal synaptic potentiation and structural plasticity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24 32359120
2017 STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function. Advances in experimental medicine and biology 24 28900914
2016 The interaction domains of transient receptor potential canonical (TRPC)1/4 and TRPC1/5 heteromultimeric channels. Biochemical and biophysical research communications 24 27131740
2014 Adaptive responses of TRPC1 and TRPC3 during skeletal muscle atrophy and regrowth. Muscle & nerve 24 23852583
2008 Induced TRPC1 expression increases protein phosphatase 2A sensitizing intestinal epithelial cells to apoptosis through inhibition of NF-kappaB activation. American journal of physiology. Cell physiology 24 18322138
2022 TRPC1 contributes to endotoxemia-induced myocardial dysfunction via mediating myocardial apoptosis and autophagy. Pharmacological research 22 35598715
2019 Differential PI(4,5)P2 sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels. Scientific reports 22 30755645
2018 Inhibition of TRPC1 prevents cardiac hypertrophy via NF-κB signaling pathway in human pluripotent stem cell-derived cardiomyocytes. Journal of molecular and cellular cardiology 22 30423318
2013 Crucial role of TRPC1 and TRPC4 in cystitis-induced neuronal sprouting and bladder overactivity. PloS one 22 23922735
2012 On the role of TRPC1 in control of Ca2+ influx, cell volume, and cell cycle. American journal of physiology. Cell physiology 22 22744003
2021 Function of the Porcine TRPC1 Gene in Myogenesis and Muscle Growth. Cells 20 33450983
2020 Tau-induced upregulation of C/EBPβ-TRPC1-SOCE signaling aggravates tauopathies: A vicious cycle in Alzheimer neurodegeneration. Aging cell 20 32815315
2022 Modulated TRPC1 Expression Predicts Sensitivity of Breast Cancer to Doxorubicin and Magnetic Field Therapy: Segue Towards a Precision Medicine Approach. Frontiers in oncology 19 35141145
2020 Transient receptor potential channels TRPC1/TRPC6 regulate lamina cribrosa cell extracellular matrix gene transcription and proliferation. Experimental eye research 19 32088241
2016 Differential expression of store-operated calcium- and proliferation-related genes in hepatocellular carcinoma cells following TRPC1 ion channel silencing. Molecular and cellular biochemistry 19 27443843
2015 Silencing of PKC-α, TRPC1 or NF-κB expression attenuates cisplatin-induced ICAM-1 expression and endothelial dysfunction. Biochemical pharmacology 19 26300057
2012 TRPC1 protein forms only one type of native store-operated channels in HEK293 cells. Biochimie 19 23079337

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