Affinage

TRIM7

E3 ubiquitin-protein ligase TRIM7 · UniProt Q9C029

Length
511 aa
Mass
56.6 kDa
Annotated
2026-06-10
43 papers in source corpus 31 papers cited in narrative 31 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

TRIM7 is a RING-type E3 ubiquitin ligase that controls protein stability across antiviral defense, innate immune signaling, cell metabolism, and regulated cell death by recognizing substrates through its C-terminal B30.2/PRYSPRY domain (PMID:35982226, PMID:35867826). Structural and biochemical work established that this domain forms a positively charged pocket that captures a 'U'-shaped C-degron defined by a C-terminal helix terminating in a hydrophobic residue followed by a terminal glutamine (the 'helix-ΦQ'/Gln-C-degron), the principal determinant of substrate selection shared by viral and cellular targets (PMID:35982226, PMID:35867826, PMID:35893676). The same domain was originally defined as the glycogenin-1 binding module of the GNIP2 isoform, and high-resolution crystal structures mapped the critical contact residues (PMID:11916970, PMID:33989636). Ligase output is tunable: MSK1 phosphorylates TRIM7 downstream of Ras-ERK signaling to stimulate its activity, and the enzyme switches ubiquitin chain topology to set substrate fate — K48 linkage for proteasomal degradation versus K63 linkage for non-degradative outcomes (PMID:25851810). As an antiviral effector, TRIM7 ubiquitinates and degrades enterovirus 2BC, SARS-CoV-2 M protein (at K14, blocking caspase-6–dependent apoptosis), and rabies virus M protein (at K115), exploiting C-terminal glutamines generated by viral protease processing; enteroviral 3C protease counters this by cleaving TRIM7 at Q24 to disable it (PMID:34062120, PMID:39616206, PMID:42047619, PMID:36106874, PMID:35972292). In innate immunity TRIM7/RNF90 drives K48-linked degradation of the signaling adaptors STING/MITA and MAVS to restrain DNA- and RNA-virus–triggered interferon responses (PMID:32126128, PMID:34512666). Beyond degradation, TRIM7 promotes K63-linked ubiquitination of ATG7 at K413 to support autophagy flux, and TRIM7 loss arrests mouse embryos at the 8-cell stage through disrupted lysosomal-autophagic function (PMID:36576150, PMID:41845426). It further governs regulated cell death and metabolism by ubiquitinating NCOA4, SLC7A11, and HSPA5 to tune ferroptosis and by degrading CPT1α to limit hepatic fatty-acid oxidation (PMID:36067704, PMID:38509147, PMID:41126348, PMID:41651430).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2002 High

    Established the first molecular partner of the TRIM7/GNIP gene product, defining the B30.2 domain as a substrate/partner-recognition module before any ligase role was known.

    Evidence Yeast two-hybrid, co-IP, and in vitro self-glucosylation assay identifying glycogenin-1 binding by GNIP2

    PMID:11916970

    Open questions at the time
    • No ubiquitination or degradation activity tested at this stage
    • Functional consequence beyond glucosylation stimulation unknown
  2. 2004 Medium

    Mapped the domain architecture, showing the B30.2 domain is necessary and sufficient for partner binding while the coiled-coil drives oligomerization.

    Evidence Y2H deletion analysis and glutaraldehyde crosslinking of GNIP isoforms

    PMID:14984203

    Open questions at the time
    • Did not connect domains to E3 ligase function
    • Stoichiometry of oligomers undefined
  3. 2015 High

    Demonstrated TRIM7 is a regulated E3 ligase whose activity is switched on by upstream kinase signaling, and that chain topology dictates substrate fate.

    Evidence In vitro kinase and ubiquitination assays plus xenograft/transgenic mouse models showing MSK1 phosphorylation and K63 ubiquitination of RACO-1

    PMID:25851810

    Open questions at the time
    • Phosphosite(s) on TRIM7 not fully mapped
    • Whether topology choice generalizes to other substrates untested here
  4. 2019 Medium

    Extended TRIM7 into oncogenic signaling control by showing it directs K48 degradation of Src kinase to suppress downstream growth pathways.

    Evidence Reciprocal Co-IP, ubiquitination assay, and xenograft models in hepatocellular carcinoma

    PMID:31802035

    Open questions at the time
    • Degron on Src not defined
    • Context dependence across tumor types unresolved
  5. 2020 High

    Defined TRIM7/RNF90 as a negative regulator of antiviral signaling by degrading the adaptors STING/MITA and the NF-κB subunit p65.

    Evidence Co-IP, ubiquitination assays, truncation mapping, and RNF90-deficient cells/mice with viral challenge

    PMID:31958511 PMID:32126128

    Open questions at the time
    • Recognition motif on STING/p65 not defined
    • Relationship to later antiviral (substrate-degrading) roles not reconciled
  6. 2021 High

    Identified TRIM7 as a cell-intrinsic antiviral ligase targeting viral proteins directly, and showed viruses can escape via single point mutations.

    Evidence Ubiquitination/proteasome rescue assays, in vitro viral evolution, and mouse infection for enterovirus 2BC; plus MAVS degradation in RNF90-deficient cells

    PMID:34062120 PMID:34512666

    Open questions at the time
    • At this stage the C-terminal degron rule not yet structurally defined
    • Apparently opposing pro- vs anti-viral roles unexplained
  7. 2022 High

    Solved the substrate-recognition code: crystal structures established that TRIM7 reads a C-terminal glutamine 'helix-ΦQ' degron generated by viral protease processing and present on cellular proteins.

    Evidence Multiple X-ray structures of B30.2 with viral and cellular peptides, structure-guided mutagenesis, and degradation assays; plus 3C cleavage at Q24 and norovirus NS6 binding

    PMID:33989636 PMID:35867826 PMID:35893676 PMID:35972292 PMID:35982226 PMID:36106874

    Open questions at the time
    • How phosphorylation/oligomerization integrate with degron capture unclear
    • Endogenous substrate repertoire bearing this degron not comprehensively mapped
  8. 2022 High

    Showed TRIM7 also acts non-degradatively via K63 ubiquitination of ATG7 to promote autophagy, broadening its mechanistic repertoire.

    Evidence Site-specific K413 mutagenesis, reciprocal Co-IP, TRIM7-deficient mice/cells, and autophagy flux assays under starvation and infection

    PMID:36576150

    Open questions at the time
    • Determinant selecting K63 vs K48 output not defined
    • Whether ATG7 carries the canonical degron untested
  9. 2022 Medium

    Connected TRIM7 to regulated cell death by ubiquitinating NCOA4 to limit ferritinophagy and ferroptosis.

    Evidence Co-IP, ubiquitination assay, and iron/lipid-peroxidation readouts in glioblastoma cells

    PMID:36067704

    Open questions at the time
    • NCOA4 degron not mapped
    • Tissue generality unknown
  10. 2024 High

    Refined the antiviral mechanism in vivo, showing TRIM7 ubiquitinates SARS-CoV-2 M at K14 to block caspase-6–dependent apoptosis and that circulating variants escape this.

    Evidence Trim7-/- mice, site-specific K14 mutagenesis, recombinant virus, and caspase-6 inhibition assays; plus SLC7A11 ubiquitination driving ferroptosis

    PMID:38509147 PMID:39616206

    Open questions at the time
    • Interplay between protective (anti-apoptotic) and restrictive antiviral functions unresolved
    • SLC7A11 (pro-ferroptotic) vs NCOA4 (anti-ferroptotic) roles appear context-divergent
  11. 2025 High

    Expanded the substrate set into metabolism and additional death pathways, including CPT1α degradation controlling fatty-acid oxidation and HSPA5/ZDHHC5 regulation of ferroptosis and cuproptosis.

    Evidence Conditional/hepatocyte-specific knockout mice, E3-dead mutant rescue, GST pull-down, acyl-biotin exchange, and ubiquitination assays

    PMID:40768810 PMID:41126348 PMID:41651430

    Open questions at the time
    • Whether these substrates share the Gln/C-degron not all tested
    • Tissue-specific selectivity mechanism unclear
  12. 2025 High

    Critically tested TRIM7's antiviral relevance in vivo against norovirus and found no requirement, tempering the generality of the C-degron antiviral model.

    Evidence Two independent Trim7-deficient mouse lines, acute/persistent MNV infection, viral titer and cytokine readouts, including STING/STAT1-null backgrounds

    PMID:40464581

    Open questions at the time
    • Reconciliation with in vitro norovirus restriction data unresolved
    • Redundancy with other E3 ligases not excluded

Open questions

Synthesis pass · forward-looking unresolved questions
  • How upstream signals, chain-type selection, and degron capture are integrated to determine which substrates TRIM7 degrades versus stabilizes in a given cell type remains unresolved, as does the discordance between in vitro antiviral activity and in vivo dispensability.
  • No unifying model for K48 vs K63 output
  • Endogenous physiological substrate hierarchy unmapped
  • In vitro vs in vivo antiviral discordance unexplained

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140096 catalytic activity, acting on a protein 8 GO:0016740 transferase activity 4 GO:0016874 ligase activity 4
Localization
GO:0005829 cytosol 1
Pathway
R-HSA-392499 Metabolism of proteins 4 R-HSA-5357801 Programmed Cell Death 4 R-HSA-1643685 Disease 3 R-HSA-168256 Immune System 3 R-HSA-9612973 Autophagy 2 R-HSA-1430728 Metabolism 1
Partners
ATG7GYG1HSPA5MAVSRELASLC7A11SRCSTING1

Evidence

Reading pass · 31 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 GNIP2 (isoform encoded by the TRIM7/GNIP gene) physically interacts with glycogenin-1 via its B30.2 domain, confirmed by co-immunoprecipitation, and stimulates glycogenin self-glucosylation 3–4-fold in vitro. Yeast two-hybrid, co-immunoprecipitation, in vitro self-glucosylation assay The Journal of biological chemistry High 11916970
2004 The B30.2 domain of GNIP2 is necessary and sufficient for interaction with glycogenin; the coiled-coil domain mediates GNIP2 self-interaction; GNIP1 and GNIP2 also form heterologous complexes. Yeast two-hybrid deletion analysis, glutaraldehyde crosslinking Archives of biochemistry and biophysics Medium 14984203
2015 MSK1, activated downstream of the Ras-Raf-MEK-ERK pathway, directly phosphorylates TRIM7, stimulating its E3 ubiquitin ligase activity. Activated TRIM7 then mediates K63-linked ubiquitination of the AP-1 co-activator RACO-1, stabilizing RACO-1 protein and promoting AP-1-dependent gene expression. In vitro kinase assay, ubiquitination assay, co-immunoprecipitation, xenograft/transgenic mouse models Nature communications High 25851810
2019 TRIM7 directly interacts with Src kinase and induces K48-linked polyubiquitination of Src, leading to proteasomal degradation of Src and suppression of the Src-mTORC1-S6K1 signaling axis in hepatocellular carcinoma cells. Co-immunoprecipitation, ubiquitination assay, in vivo xenograft models Cell death and differentiation Medium 31802035
2019 TRIM7 activates c-Jun/AP-1 signaling in vascular smooth muscle cells, and knockdown of TRIM7 inhibits VSMC proliferation and migration and arrests cells at G1-S phase. siRNA knockdown, cell cycle analysis, gain- and loss-of-function in apoE-/- atherosclerosis mouse model IUBMB life Medium 31625258
2020 TRIM7 interacts with p65 (NF-κB subunit) via its C-terminal domain (unique from GNIP1 isoform) and promotes K48-linked ubiquitination and proteasomal degradation of p65, suppressing NF-κB signaling in lung cancer cells. Co-immunoprecipitation, ubiquitination assay, in vivo xenograft, truncation mutant analysis Cellular signalling Medium 31958511
2020 TRIM7 (as RNF90) promotes K48-linked ubiquitination and proteasomal degradation of MITA/STING, negatively regulating DNA virus-triggered innate immune responses; RNF90-deficient mice show increased resistance to DNA virus infection. Co-immunoprecipitation, ubiquitination assay, RNF90-deficient BMDCs/BMMs/MEFs, in vivo viral challenge PLoS pathogens High 32126128
2020 TRIM7 ubiquitinates BRMS1 (breast cancer metastasis suppressor 1), promoting its degradation and thereby facilitating osteosarcoma cell migration and invasion; m6A modification of TRIM7 mRNA by METTL3/YTHDF2 regulates TRIM7 expression. Co-immunoprecipitation, mass spectrometry, ubiquitination assay, RNA immunoprecipitation, PDX mouse model EBioMedicine Medium 32853985
2021 TRIM7 is a cell-intrinsic antiviral E3 ubiquitin ligase that restricts multiple human enteroviruses by targeting the viral 2BC membrane remodeling protein for ubiquitination and proteasome-dependent degradation. A single point mutation in viral 2C ATPase confers TRIM7 resistance. Ubiquitination assay, proteasome inhibitor rescue, in vitro evolution, in vivo mouse infection model Cell High 34062120
2021 TRIM7 (as RNF90) promotes K48-linked ubiquitination and proteasomal degradation of MAVS, negatively regulating RNA virus-triggered innate immune responses independently of STING. Co-immunoprecipitation, ubiquitination assay, RNF90-deficient cells (HaCaTs, MEFs, BMDMs), in vivo mouse model Frontiers in immunology High 34512666
2021 TRIM7 reduces Src protein abundance via the ubiquitin-proteasome pathway in clear cell renal cell carcinoma cells, thereby suppressing HIF-1α accumulation through the Src-PI3K/AKT/mTOR axis and reactive oxygen species production. siRNA knockdown, ubiquitination assay, PI3K/AKT/mTOR pathway analysis Cell biology international Low 34936717
2021 The B30.2 domain of TRIM7 (crystal structures at 1.6 Å and 1.8 Å) forms a positively charged cavity. Mutational analysis identified Leu423, Ser499, and Cys501 as critical residues for binding glycogenin-1, with the C-terminal 33 amino acids of GN1 required for this interaction. X-ray crystallography, mutational analysis, molecular dynamics simulation The Journal of biological chemistry High 33989636
2022 TRIM7 directly binds and K48-ubiquitinates NCOA4, reducing NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells. Co-immunoprecipitation, ubiquitination assay, lentiviral KD/OE, lipid peroxidation and iron assays Redox biology Medium 36067704
2022 Crystal structures of TRIM7 B30.2 domain in complex with viral 2C peptides reveal that a C-terminal glutamine residue is the primary determinant for TRIM7 substrate recognition. This 'Gln/C-degron' mechanism is shared by norovirus, SARS-CoV-2, and cellular substrates; TRIM7 triggers ubiquitination and degradation of these substrates. X-ray crystallography, structure-guided mutagenesis, in vitro/cellular ubiquitination and degradation assays Nature chemical biology High 35982226
2022 The B30.2 domain of TRIM7 forms a positively charged binding pocket that recognizes a 'U'-shaped Gln/C-degron; the four C-terminal residues of substrates are critical, with the terminal glutamine as the principal determinant. Crystal structures of TRIM7B30.2 with multiple peptides established a Gln/C-degron pathway. X-ray crystallography, in vitro biochemical assays, cellular degradation assays Proceedings of the National Academy of Sciences of the United States of America High 35867826
2022 TRIM7's PRYSPRY domain captures substrates with a C-terminal helix terminating in a hydrophobic residue followed by glutamine ('helix-ΦQ' degron). This explains TRIM7's ability to restrict Coxsackievirus and norovirus, as viral 3C protease processing generates C-terminal glutamines on non-structural proteins. Cellular glycogenin also harbors this degron motif. Biochemical binding assays, viral infection assays, structural inference Viruses Medium 35893676
2022 Enterovirus 3C protease (3Cpro) from CVB3 and poliovirus cleaves TRIM7 at glutamine 24 (Q24), generating a truncated TRIM7 with dampened E3 ubiquitin ligase activity and loss of antiviral function. In vitro cleavage assay, mutagenesis (Q24), ubiquitination assay, viral infection assays Journal of virology High 36106874
2022 Norovirus NS6 protease (but not the NS6-7 precursor polyprotein) directly binds the substrate-binding domain of Trim7; viruses that escape Trim7 do so by reducing NS6-7 polyprotein cleavage, preventing generation of the Trim7-recognized C-terminal glutamine on NS6. CRISPR activation screen, in vitro evolution, direct binding assay, viral attenuation analysis Journal of virology High 35972292
2023 TRIM7 (as RNF90) promotes K63-linked ubiquitination of ATG7 at lysine 413, positively regulating autophagosome accumulation and autophagy flux; this ubiquitination is required for ATG7's function during starvation, rapamycin stimulation, and L. monocytogenes infection. Co-immunoprecipitation, ubiquitination assay (site-specific K413 mutation), TRIM7-deficient mice and cells, autophagy flux assays Autophagy High 36576150
2023 TRIM7 interacts with MAVS in HEK293T cells (co-localization and co-immunoprecipitation) and positively regulates RIG-I/MDA5/MAVS-mediated IFN-β signaling during EMCV infection, suppressing viral replication. Co-immunoprecipitation, co-localization, IFN-β promoter reporter assay, siRNA knockdown/overexpression Veterinary microbiology Low 37023504
2024 TRIM7 ubiquitinates SARS-CoV-2 membrane (M) protein at K14, protecting cells from apoptosis; this requires caspase-6 inhibition. Trim7-/- mice show increased apoptosis, viral titers, and pathology. Mutations at M-K14 in circulating variants impair this ubiquitination. Trim7-/- mouse model, site-specific mutagenesis (K14), recombinant virus (M-K14/K15R), caspase-6 inhibition assay, viral titer measurement Nature communications High 39616206
2024 TRIM7 interacts with SLC7A11 via its B30.2/SPRY domain and promotes K48-linked polyubiquitination of SLC7A11, suppressing the SLC7A11/GPX4 axis and inducing ferroptosis in gastric cancer cells. Co-immunoprecipitation, ubiquitination assay, in vivo xenograft, domain mapping Scientific reports Medium 38509147
2024 TRIM7 positively regulates Nrf2 stability by reducing K48-linked ubiquitination of Nrf2 (possibly displacing Keap1), thereby activating Nrf2 signaling in HCC cells. Co-immunoprecipitation, ubiquitination assay, TRIM7 KD/OE cell models, xenograft Phytomedicine Low 39461200
2025 TRIM7 directly interacts with HSPA5 via its PRY/SPRY domain (binding to the substrate-binding domain of HSPA5) and promotes K48-linked polyubiquitination and proteasomal degradation of HSPA5, suppressing GPX4 expression and driving ferroptosis in ischemic neurons. Co-immunoprecipitation, GST pull-down, ubiquitination assay, Trim7 knockout mice, adenoviral KD/OE in neurons Cell & bioscience Medium 41126348
2025 TRIM7 (as RNF90) acts as an E3 ubiquitin ligase to promote proteasomal degradation of CPT1α (a rate-limiting enzyme in mitochondrial fatty acid oxidation), regulating hepatic lipid metabolism; hepatocyte-specific RNF90 knockout increased CPT1α and enhanced FAO, while E3 ligase-deficient mutant RNF90 had no effect. Hepatocyte-specific knockout mice, co-immunoprecipitation, ubiquitination assay, E3 ligase-dead mutant, FAO activity assay The Journal of biological chemistry High 41651430
2025 TRIM7 mediates ubiquitin-dependent degradation of the TGEV nucleocapsid (N) protein and also enhances RIG-I-mediated type I interferon signaling to suppress TGEV replication. Co-immunoprecipitation, ubiquitination assay, RNA-seq with RIG-I signaling modulation, overexpression/knockdown Veterinary research Medium 41194212
2025 TRIM7 competes with P2X7 for binding to the palmitoyl-transferase ZDHHC5, leading to ubiquitination-mediated degradation of ZDHHC5; this disrupts ZDHHC5-dependent palmitoylation of P2X7, preventing P2X7 membrane localization and copper efflux, thereby inducing cuproptosis in synovial macrophages. Co-immunoprecipitation, fluorescence co-localization, acyl-biotin exchange assay, TRIM7 conditional knockout mice, ICP-MS Phytomedicine Medium 40768810
2025 TRIM7 interacts with CMPK2 and negatively regulates CMPK2 expression, suppressing inflammation and apoptosis during renal ischemia-reperfusion injury; TRIM7 knockout exacerbated injury and CMPK2 inhibition reversed injury in TRIM7-KO cells. Co-immunoprecipitation, TRIM7 KO mice, overexpression, CMPK2 inhibitor rescue International immunopharmacology Low 41723894
2026 TRIM7 depletion in mouse embryos (via morpholino or siRNA) causes developmental arrest at the 8-cell stage by disrupting lysosomal-autophagic pathways; rapamycin-mediated autophagy activation partially rescues embryo development. Morpholino and siRNA knockdown, scRNA-seq, proteomics, LC3B immunostaining, EU incorporation, rapamycin rescue Journal of translational medicine Medium 41845426
2026 TRIM7 promotes K48-linked ubiquitination and proteasomal degradation of RABV matrix protein (M) at lysine 115, inhibiting rabies virus replication; direct interaction between TRIM7 and RABV-M was demonstrated. Co-immunoprecipitation, ubiquitination assay (K115 mutagenesis), proteasome inhibitor rescue, overexpression/knockdown, in vivo suckling mouse model Emerging microbes & infections Medium 42047619
2025 NEGATIVE FINDING: Trim7-deficient mice (two independent lines) show no difference in murine norovirus (MNV) burden, tissue distribution, or cytokine responses compared to wild-type mice in both acute and persistent infection models, even when STING and STAT1 pathways are removed. Two independent Trim7-deficient mouse lines, acute and persistent MNV infection models, viral titer measurement, cytokine analysis Journal of virology High 40464581

Source papers

Stage 0 corpus · 43 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2022 TRIM7 modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells. Redox biology 130 36067704
2020 N6-Methyladenosine modification of the TRIM7 positively regulates tumorigenesis and chemoresistance in osteosarcoma through ubiquitination of BRMS1. EBioMedicine 97 32853985
2015 The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling. Nature communications 89 25851810
2021 TRIM7 inhibits enterovirus replication and promotes emergence of a viral variant with increased pathogenicity. Cell 71 34062120
2020 RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation. PLoS pathogens 68 32126128
2019 The E3 ubiquitin ligase TRIM7 suppressed hepatocellular carcinoma progression by directly targeting Src protein. Cell death and differentiation 57 31802035
2002 GNIP, a novel protein that binds and activates glycogenin, the self-glucosylating initiator of glycogen biosynthesis. The Journal of biological chemistry 46 11916970
2020 E3 ubiquitin ligase TRIM7 negatively regulates NF-kappa B signaling pathway by degrading p65 in lung cancer. Cellular signalling 41 31958511
2022 A C-terminal glutamine recognition mechanism revealed by E3 ligase TRIM7 structures. Nature chemical biology 40 35982226
2004 Structure-function analysis of GNIP, the glycogenin-interacting protein. Archives of biochemistry and biophysics 32 14984203
2019 TRIM7 promotes proliferation and migration of vascular smooth muscle cells in atherosclerosis through activating c-Jun/AP-1. IUBMB life 28 31625258
2023 TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection. Autophagy 27 36576150
2022 C-terminal glutamine acts as a C-degron targeted by E3 ubiquitin ligase TRIM7. Proceedings of the National Academy of Sciences of the United States of America 27 35867826
2021 Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS. Frontiers in immunology 24 34512666
2024 The E3 ligase TRIM7 suppresses the tumorigenesis of gastric cancer by targeting SLC7A11. Scientific reports 22 38509147
2022 TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing. Viruses 19 35893676
2021 TRIM7 suppresses cell invasion and migration through inhibiting HIF-1α accumulation in clear cell renal cell carcinoma. Cell biology international 16 34936717
2024 TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication. Nature communications 15 39616206
2023 TRIM7 inhibits encephalomyocarditis virus replication by activating interferon-β signaling pathway. Veterinary microbiology 15 37023504
2022 Selective Polyprotein Processing Determines Norovirus Sensitivity to Trim7. Journal of virology 15 35972292
2022 Enterovirus 3C Protease Cleaves TRIM7 To Dampen Its Antiviral Activity. Journal of virology 13 36106874
2024 Fangchinoline suppresses hepatocellular carcinoma by regulating ROS accumulation via the TRIM7/Nrf2 signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology 12 39461200
2024 Blueberry anthocyanins improve liver fibrosis by regulating NCOA4 ubiquitination through TRIM7 to affect ferroptosis of hepatic stellate cells. American journal of physiology. Gastrointestinal and liver physiology 10 38290991
2021 MicroRNA-4491 enhances cell proliferation and inhibits cell apoptosis in non-small cell lung cancer via targeting TRIM7. Oncology letters 10 34149902
2024 A C-Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7. ACS chemical biology 9 38934237
2021 Crystal structure and mutational analysis of the human TRIM7 B30.2 domain provide insights into the molecular basis of its binding to glycogenin-1. The Journal of biological chemistry 8 33989636
2024 The Dual Role of TRIM7 in Viral Infections. Viruses 7 39205259
2023 The antiferroptotic role of TRIM7: Molecular mechanism and synergistic effect with temozolomide. Cancer innovation 5 38089750
2022 Study on the expression of TRIM7 in peripheral blood mononuclear cells of patients with sepsis and its early diagnostic value. BMC infectious diseases 4 36402943
2025 A brief overview of the E3 ubiquitin ligase: TRIM7. Cellular signalling 3 40419231
2025 Trim7 does not have a role in the restriction of murine norovirus infection in vivo. Journal of virology 3 40464581
2025 Columbianadin targets TRIM7 to maintain P2X7 palmitoylation, inhibiting cuproptosis in synovial M2 macrophages. Phytomedicine : international journal of phytotherapy and phytopharmacology 3 40768810
2024 TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication. bioRxiv : the preprint server for biology 3 38948778
2024 TRIM7 knockdown protects against LPS-induced autophagy, ferroptosis, and inflammatory responses in human bronchial epithelial cells. Naunyn-Schmiedeberg's archives of pharmacology 3 39446150
2025 E3 Ubiquitin Ligase TRIM7 Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Inhibiting NLRP3 Inflammasome Activation. The American journal of pathology 2 39864619
2025 Trim7 aggravates ischemic stroke-associated ferroptosis by promoting ubiquitin-mediated degradation of HSPA5. Cell & bioscience 1 41126348
2026 Gastrodin alleviates high fructose-induced podocyte mitochondria-mediated apoptosis by inhibiting NLRP6 to facilitate TRIM7-triggered Bok mRNA degradation. International journal of biological sciences 0 41608624
2026 RNF90 promotes hepatic steatosis by degrading CPT1α to suppress fatty acid oxidation. The Journal of biological chemistry 0 41651430
2026 TRIM7 negatively regulates CMPK2 suppressing inflammation and apoptosis in renal ischemia-reperfusion injury. International immunopharmacology 0 41723894
2026 TRIM7-mediated autophagy-lysosomal signaling is essential for preimplantation development in mice. Journal of translational medicine 0 41845426
2026 TRIM7 Inhibits Rabies Virus Replication by Promoting K48-Linked Ubiquitination and Degradation of RABV-M. Emerging microbes & infections 0 42047619
2025 TRIM7 suppresses transmissible gastroenteritis virus replication by targeting the degradation of N protein and activating RIG-I-mediated type I IFN antiviral response. Veterinary research 0 41194212
2024 Trim7 does not have a role in the restriction of murine norovirus infection in vivo. bioRxiv : the preprint server for biology 0 39464121

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