Affinage

THRAP3

Thyroid hormone receptor-associated protein 3 · UniProt Q9Y2W1

Length
955 aa
Mass
108.7 kDa
Annotated
2026-06-10
25 papers in source corpus 20 papers cited in narrative 20 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

THRAP3 (TRAP150) is a nuclear SR-like RNA-processing protein that couples pre-mRNA splicing to downstream RNA fate, localizing to nuclear speckles and active RNA polymerase II transcription loci where it activates splicing, remains bound to spliced mRNA in association with the exon junction complex, and can trigger nuclear mRNA degradation through a domain separable from its splicing-activation function (PMID:20123736, PMID:23778535). It tunes splice-site choice through partner interactions: it preferentially associates with U1 snRNP and CPSF to regulate premature cleavage and polyadenylation transcripts (PMID:25326322), and it antagonizes PSF/SFPQ-mediated splicing suppression by binding the RRMs of PSF through a dedicated PSF-interacting domain that blocks PSF's RNA binding (PMID:26261210). THRAP3 selectively governs splicing and nuclear export of DNA-damage-response transcripts including ATM, and—acting with BCLAF1—its loss or cancer-associated mutation impairs DNA repair and causes genotoxic hypersensitivity and genomic instability (PMID:22424773, PMID:29112714); it further safeguards genome integrity by interacting with arginine-methylated DDX5 to recruit the exoribonuclease XRN2 and resolve R-loops (PMID:34697388). In metabolic tissues THRAP3 binds PPARγ specifically when phosphorylated at Ser273 by CDK5—an interaction itself gated by CLK1 phosphorylation of THRAP3 at Ser243—to drive diabetic gene programming, cooperates with HELZ2 at PPARγ-response elements for adipocyte differentiation, maintains PPARγ mRNA stability, and sequesters AMPK in the nucleus to restrain hepatic autophagy (PMID:23525231, PMID:25316675, PMID:34526909, PMID:34370683, PMID:37524868). THRAP3 also negatively regulates SOX9 during chondrogenesis (PMID:28770354) and, in leukemia, recruits SLU7 to promote GIT2 exon-14 skipping and confer ferroptosis resistance (PMID:41326370).

Mechanistic history

Synthesis pass · year-by-year structured walk · 19 steps
  1. 2010 High

    Established THRAP3 as a bona fide splicing activator that physically and functionally links splicing to mRNA fate, answering whether it is merely speckle-associated or mechanistically engaged in RNA processing.

    Evidence In vivo splicing assays, RNA tethering, co-IP with EJC components, and domain mapping in human cells

    PMID:20123736

    Open questions at the time
    • The molecular trigger distinguishing splicing activation from degradation outcomes was not resolved
    • Endogenous transcript targets were not defined
  2. 2012 Medium

    Connected THRAP3's RNA-processing role to the DNA damage response by showing it is actively excluded from damage sites and that its loss sensitizes cells to genotoxins.

    Evidence Phosphoproteomics, immunofluorescence exclusion from damage foci, and knockdown clonogenic survival assays

    PMID:22424773

    Open questions at the time
    • Mechanism of exclusion from damage foci unresolved
    • Direct DDR transcript targets not yet identified
  3. 2013 High

    Defined a metabolic role by showing THRAP3 partners with HELZ2 and PPARγ at adipogenic enhancers, distinguishing it functionally from its paralog BCLAF1 in mRNA distribution.

    Evidence Yeast two-hybrid, reciprocal co-IP, domain mapping, ChIP at PPARγ-response elements, and paralog-comparison fractionation assays

    PMID:23525231 PMID:23778535

    Open questions at the time
    • Whether enhancer recruitment reflects co-transcriptional splicing or transcriptional coactivation not separated
    • Direct vs indirect contribution to differentiation unclear
  4. 2014 High

    Revealed phospho-dependent target selection: THRAP3 binds PPARγ only when CDK5 phosphorylates Ser273, providing a mechanistic basis and in vivo rationale for its role in diabetic gene programming.

    Evidence Phospho-specific binding/co-IP, adipocyte knockdown, and ASO knockdown in high-fat-fed mice with metabolic phenotyping

    PMID:25316675

    Open questions at the time
    • How docking translates into gene reprogramming mechanistically not detailed
    • Downstream transcript targets in vivo not enumerated
  5. 2014 Medium

    Clarified THRAP3's splice-site selectivity by linking it to U1 snRNP/CPSF and showing it regulates premature cleavage and polyadenylation in composite terminal exons.

    Evidence Co-IP, co-fractionation, splicing reporter assays, and U1 snRNP inhibition

    PMID:25326322

    Open questions at the time
    • Genome-wide PCPA targets not mapped
    • Single-lab reporter system limits generality
  6. 2015 High

    Provided a direct biochemical mechanism for splicing antagonism: THRAP3's PID domain occupies PSF/SFPQ RRMs to block its RNA binding without disrupting DBHS dimerization.

    Evidence Domain mapping, in vitro RNA-binding competition, and transcriptome-wide RASL-Seq with knockdown in T cells

    PMID:26261210

    Open questions at the time
    • Structural details of the PID-RRM interface not solved
    • Generality beyond T-cell splicing events untested
  7. 2016 Medium

    Linked THRAP3 phosphorylation status to interactome rewiring, showing Ser248/Ser253 phosphorylation reshapes its association with RNA-processing partners in prostate cancer.

    Evidence Quantitative phosphoproteomics and pull-downs with phosphomimetic/nonphosphorylatable mutants

    PMID:26841317

    Open questions at the time
    • Functional consequences of altered interactions not tested
    • Responsible kinase not identified
  8. 2017 Medium

    Extended THRAP3's regulatory reach beyond splicing to transcription-factor control, identifying it as a negative regulator of SOX9 during chondrogenesis.

    Evidence LC-MS/MS purification from knock-in mice, co-IP, domain mapping, and knockdown/overexpression in chondrogenic cells

    PMID:28770354

    Open questions at the time
    • Whether repression is transcriptional or post-transcriptional unresolved
    • In vivo chondrogenesis phenotype not established
  9. 2017 Medium

    Mechanistically tied DDR sensitivity to selective splicing/export, showing THRAP3 with BCLAF1 controls processing of DDR transcripts including ATM and that cancer mutations impair repair.

    Evidence Knockdown, comet/γH2AX assays, splicing and export assays, and mutant THRAP3 expression

    PMID:29112714

    Open questions at the time
    • Direct vs indirect transcript regulation not fully separated
    • Single-lab evidence
  10. 2017 Low

    Proposed a mitotic role through regulation of mitotic-regulator mRNA abundance, linking THRAP3 loss to chromosome misalignment.

    Evidence siRNA knockdown, mitotic defect scoring, and RT-PCR of mitotic regulators

    PMID:28895891

    Open questions at the time
    • Single knockdown approach with only correlative mechanistic link
    • Specific causal transcripts not validated
  11. 2021 Medium

    Defined THRAP3's R-loop resolution mechanism: it reads methylated DDX5 and recruits XRN2 to R-loops, connecting its RNA-processing role to genome stability.

    Evidence Co-IP, DRIP, proximity ligation, and knockdown with γH2AX readout

    PMID:34697388

    Open questions at the time
    • Which methyltransferase marks DDX5 not addressed
    • Genome-wide R-loop targets not mapped
  12. 2021 Medium

    Identified an upstream kinase layer controlling THRAP3-PPARγ docking, showing CLK1 phosphorylation of Ser243 is required and that the CLK1-THRAP3-PPARγ axis impairs adipose browning.

    Evidence Phosphoproteomics, kinase assay, co-IP, and CLK1 knockout/inhibition in mice

    PMID:34526909

    Open questions at the time
    • Interplay between Ser243 phosphorylation and PPARγ Ser273 phosphorylation not structurally resolved
  13. 2021 Medium

    Revealed a post-transcriptional metabolic function: THRAP3 stabilizes PPARγ mRNA and is required for TZD anti-inflammatory action in adipocytes.

    Evidence Knockdown, actinomycin D chase, RT-qPCR/Western, and lipolysis assays

    PMID:34370683

    Open questions at the time
    • Mechanism of mRNA stabilization not defined
    • Direct binding to PPARγ mRNA not shown
  14. 2021 Medium

    Connected THRAP3 to oncogenic cell-cycle control by showing nuclear PD-L1 recruits it to upregulate BUB1 in BRAF-mutant colorectal cancer.

    Evidence Co-IP, nuclear fractionation, knockdown, reporter assays, and xenografts

    PMID:34923044

    Open questions at the time
    • How THRAP3 drives BUB1 expression mechanistically unclear
    • Direct vs scaffold role not separated
  15. 2023 Medium

    Uncovered a non-splicing metabolic mechanism: THRAP3 sequesters AMPK in the nucleus via its C-terminus to suppress hepatic autophagy, with liver-specific knockout improving NAFLD.

    Evidence Liver-specific knockout mice, co-IP, fractionation, AMPK activity, and autophagic flux assays

    PMID:37524868

    Open questions at the time
    • Structural basis of AMPK sequestration not resolved
    • Reconciliation with nuclear RNA-processing roles unaddressed
  16. 2023 Medium

    Structurally defined THRAP3's core complex, mapping a Thrap3-Erh-Bclaf1 (TEB) assembly through interaction surfaces on otherwise disordered proteins.

    Evidence Cross-linking mass spectrometry (DSSO) of endogenous immunoprecipitated complexes

    PMID:35865489

    Open questions at the time
    • Functional role of the TEB complex not validated
    • Stoichiometry and high-resolution structure unknown
  17. 2023 Medium

    Showed THRAP3 itself is an m6A-regulated target, with METTL3-mediated methylation stabilizing its mRNA to support myeloma proliferation, an axis suppressed by metformin.

    Evidence MeRIP, METTL3 overexpression, knockdown, mRNA stability, and rescue experiments

    PMID:36762777

    Open questions at the time
    • Reader protein mediating stabilization not identified
    • Downstream THRAP3 effector pathway in myeloma not defined
  18. 2025 Medium

    Demonstrated a cancer splicing-effector role: THRAP3 recruits SLU7 to drive GIT2 exon-14 skipping and confer ferroptosis resistance in AML.

    Evidence Co-IP, alternative splicing assays, knockdown/overexpression, ferroptosis assays, and xenografts

    PMID:41326370

    Open questions at the time
    • How GIT2 isoform alters iron/GSH metabolism mechanistically not fully traced
    • Breadth of THRAP3-SLU7 splicing program unknown
  19. 2026 Medium

    Extended THRAP3 into skeletal muscle, showing it is required for myogenic differentiation and thyroid hormone-responsive gene expression.

    Evidence THRAP3 knockout C2C12 myotubes, RT-qPCR/Western, myotube morphology, and T3 stimulation

    PMID:41570000

    Open questions at the time
    • Whether effect is via splicing or transcriptional regulation unresolved
    • Direct muscle gene targets not mapped

Open questions

Synthesis pass · forward-looking unresolved questions
  • How THRAP3 integrates its disparate roles—co-transcriptional splicing, mRNA stability/degradation, R-loop resolution, transcription-factor docking, and AMPK sequestration—into a unified mechanism, and how its phosphorylation state selects among them, remains unresolved.
  • No unifying structural model of THRAP3 domains coordinating splicing vs non-RNA functions
  • No comprehensive transcriptome map of direct THRAP3 RNA targets across tissues
  • Regulatory logic linking specific phosphosites to specific partner choices undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 3 GO:0060090 molecular adaptor activity 3 GO:0140098 catalytic activity, acting on RNA 3 GO:0098772 molecular function regulator activity 2 GO:0140110 transcription regulator activity 2
Localization
GO:0005634 nucleus 3 GO:0005654 nucleoplasm 2
Pathway
R-HSA-1430728 Metabolism 3 R-HSA-73894 DNA Repair 3 R-HSA-8953854 Metabolism of RNA 3 R-HSA-74160 Gene expression (Transcription) 2
Partners
BCLAF1DDX5HELZ2PPARGSFPQSLU7SOX9XRN2
Complex memberships
TEB complex (THRAP3-ERH-BCLAF1)exon junction complex (associated)

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2010 TRAP150 (THRAP3) co-localizes with splicing factors in nuclear speckles, is required for pre-mRNA splicing in vivo, activates splicing, remains associated with spliced mRNA after splicing, interacts with the exon junction complex (EJC), and when tethered to a precursor mRNA, triggers nuclear mRNA degradation independently of nonsense-mediated decay. Splicing activation and mRNA degradation functions were mapped to separable domains. Co-localization (immunofluorescence), in vivo splicing assays, RNA tethering assays, co-immunoprecipitation with EJC components Nucleic acids research High 20123736
2012 THRAP3 is excluded from sites of DNA damage following genotoxic stress, and THRAP3 depletion causes cellular hypersensitivity to DNA-damaging agents, implicating it in the DNA damage response through its RNA processing functions. Mass spectrometry-based phosphoproteomics, immunofluorescence (exclusion from DNA damage foci), siRNA knockdown with clonogenic survival assays Molecular cell Medium 22424773
2013 THRAP3 physically associates with HELZ2 and PPARγ in differentiated 3T3-L1 adipocytes. HELZ2 interacts with the serine/arginine-rich domain and BCLAF1-homologous region of THRAP3, while THRAP3 directly binds two helicase motifs in HELZ2. THRAP3 and HELZ2 are co-recruited to PPARγ-response elements in Fabp4/aP2 and Adipoq gene enhancers in a ligand-dependent manner, and THRAP3 knockdown attenuates PPARγ-driven adipocyte differentiation. Yeast two-hybrid, co-immunoprecipitation, mass spectrometry, chromatin immunoprecipitation (ChIP), siRNA knockdown with gene expression and lipid droplet readouts Molecular endocrinology (Baltimore, Md.) High 23525231
2013 TRAP150 (THRAP3) localizes at active transcription loci in an RNA polymerase II-dependent manner and co-localizes with the EJC protein Magoh. Unlike BCLAF1 (Btf), TRAP150 depletion does not affect nuclear export of β-tropomyosin transcripts or global polyadenylated RNA cytoplasmic distribution, indicating distinct roles for the two paralogs in mRNA distribution. Immunofluorescence at reporter gene loci, siRNA knockdown, nuclear/cytoplasmic fractionation with RNA quantification Nucleus (Austin, Tex.) Medium 23778535
2014 THRAP3 (Thrap3) directly interacts with PPARγ specifically when PPARγ is phosphorylated at Ser273 by CDK5, and this interaction controls diabetic gene programming in adipocytes. Knockdown of Thrap3 restores genes dysregulated by CDK5 phosphorylation of PPARγ, and in vivo antisense oligonucleotide-mediated reduction of Thrap3 in adipose tissue improves hyperglycemia and insulin resistance in high-fat-fed mice. Co-immunoprecipitation, phospho-specific binding assays, siRNA knockdown in cultured adipocytes, antisense oligonucleotide knockdown in mouse adipose tissue, metabolic phenotyping Genes & development High 25316675
2014 TRAP150 interacts with the cleavage and polyadenylation specificity factor (CPSF) and co-fractionates with CPSF and RNA polymerase II. TRAP150 preferentially associates with U1 snRNP and activates splicing in composite terminal exons but not authentic terminal exons, providing a mechanism to regulate premature cleavage and polyadenylation (PCPA) transcripts. Co-immunoprecipitation, co-fractionation, in vivo splicing reporter assays, U1 snRNP inhibition experiments Nucleic acids research Medium 25326322
2015 TRAP150 binds the RNA recognition motifs (RRMs) of PSF/SFPQ via a 70-residue PSF-interacting domain (PID). This interaction directly inhibits PSF's binding to RNA through RRM2, but does not prevent PSF dimerization with other DBHS proteins. TRAP150 antagonizes PSF-mediated splicing suppression across ~40 T cell splicing events. Co-immunoprecipitation, domain mapping with deletion mutants, in vitro RNA-binding competition assays, RASL-Seq, siRNA knockdown Nucleic acids research High 26261210
2016 THRAP3 phosphorylation at Ser248 and Ser253 is significantly reduced in androgen-independent prostate cancer cells. Pull-down assays show that the phosphorylation state at these residues alters THRAP3's interaction partners: 32 proteins uniquely bind the nonphosphorylatable mutant and 31 uniquely bind the phosphomimetic form, with many differentially interacting proteins involved in RNA splicing and processing. Quantitative phosphoproteomics (mass spectrometry), pull-down assays with phosphomimetic and nonphosphorylatable THRAP3 mutants Proteomics Medium 26841317
2017 THRAP3 is a component of a SOX9 transcriptional complex and negatively regulates SOX9 transcriptional activity during chondrogenesis. The interaction is mediated between the proline-, glutamine-, and serine-rich (PQS) domain of SOX9 and the innominate domain of THRAP3. THRAP3 knockdown increases Col2a1 expression, and co-overexpression of THRAP3 and SOX9 reduces Col2a1 levels more than SOX9 alone. LC-MS/MS purification of FLAG-tagged SOX9-binding proteins from knock-in mice, co-immunoprecipitation, domain mapping, siRNA knockdown, overexpression in chondrogenic cells Journal of bone and mineral metabolism Medium 28770354
2017 Depletion of THRAP3 and/or BCLAF1 causes sensitivity to DNA-damaging agents, defective DNA repair, and genomic instability. THRAP3 and BCLAF1 regulate selective mRNA splicing and nuclear export of transcripts encoding key DDR proteins including ATM kinase. Cancer-associated mutations in THRAP3 deregulate processing of THRAP3/BCLAF1-regulated transcripts and impair DNA repair. siRNA knockdown, clonogenic survival assays, comet assay, γH2AX foci, RNA splicing and nuclear export assays, mutant THRAP3 expression Nucleic acids research Medium 29112714
2017 Depletion of TRAP150 (THRAP3) causes mitotic chromosome misalignment defects and alters the abundance of transcripts encoding mitotic regulators, suggesting TRAP150 controls mitotic progression through regulation of mitotic checkpoint regulator mRNAs. siRNA knockdown, immunofluorescence (mitotic defect scoring), RT-PCR for mitotic regulator transcripts International journal of molecular sciences Low 28895891
2021 Thrap3 interacts with methylated DDX5 (arginine methylation required) and localizes to R-loops. The Thrap3-DDX5 axis recruits XRN2 (5'-3' exoribonuclease 2) to R-loops to promote their resolution. Loss of Thrap3 increases R-loop accumulation and DNA damage. Co-immunoprecipitation, S9.6 antibody-based R-loop detection (DRIP assay), proximity ligation assays, Thrap3 knockdown with γH2AX readout Experimental & molecular medicine Medium 34697388
2021 Nuclear PD-L1 interacts with THRAP3 to upregulate BUB1 expression, thereby accelerating cell cycle progression in BRAF-mutated colorectal cancer cells. PD-L1 translocation into the nucleus is facilitated by binding of p-ERK. Co-immunoprecipitation, nuclear fractionation, siRNA knockdown, reporter assays, xenograft models Cancer letters Medium 34923044
2021 CLK1 phosphorylates THRAP3 at Ser243, and this phosphorylation is required for THRAP3's regulatory interaction with phosphorylated PPARγ. CLK1-THRAP3 interaction was confirmed by co-immunoprecipitation. This CLK1-THRAP3-PPARγ axis impairs adipose tissue browning and insulin sensitivity. Phosphoproteomics, co-immunoprecipitation, kinase assay (CLK1 phosphorylation of THRAP3), CLK1 genetic knockout and chemical inhibition in mice Frontiers in physiology Medium 34526909
2021 THRAP3 depletion in 3T3-L1 adipocytes reduces PPARγ mRNA stability (demonstrated by actinomycin D chase), decreases PPARγ protein levels, and attenuates TZD-mediated anti-inflammatory actions including suppression of lipolysis and pro-inflammatory gene expression. siRNA knockdown, actinomycin D mRNA stability assay, RT-qPCR, Western blot, lipolysis assay Journal of molecular endocrinology Medium 34370683
2023 Thrap3 deficiency increases cytosolic translocation of AMPK from the nucleus and enhances AMPK activation through direct physical interaction between AMPK and the C-terminal domain of Thrap3. Liver-specific Thrap3 knockout improves lipid accumulation, enhances autophagy, and improves mitochondrial function in a high-fat diet NAFLD model. Liver-specific Thrap3 knockout mice, co-immunoprecipitation, subcellular fractionation, AMPK activity assays, autophagic flux assays Experimental & molecular medicine Medium 37524868
2023 Cross-linking mass spectrometry of endogenous immunoprecipitated complexes demonstrates that Thrap3 and Bclaf1 interact closely with each other and with Erh, mapping interaction surfaces to the non-disordered portions of these largely disordered proteins, suggesting they form a novel TEB (Thrap3-Erh-Bclaf1) complex. Cross-linking mass spectrometry (XL-MS) with MS-cleavable crosslinker DSSO on endogenous immunoprecipitated proteins Wellcome open research Medium 35865489
2023 METTL3-mediated m6A methylation stabilizes THRAP3 mRNA in multiple myeloma cells. Metformin reduces METTL3 activity, decreasing m6A modification on THRAP3 mRNA and reducing its stability and expression. THRAP3 knockdown reverses the pro-proliferative/anti-apoptotic effects of METTL3 overexpression. MeRIP (m6A RNA immunoprecipitation), siRNA knockdown, METTL3 overexpression, mRNA stability assays, rescue experiments Cell cycle (Georgetown, Tex.) Medium 36762777
2025 THRAP3 recruits the splicing factor SLU7 to facilitate GIT2 Exon14 skipping, thereby promoting ferroptosis resistance in AML cells by inhibiting iron accumulation and promoting GSH synthesis. THRAP3 knockdown suppresses AML cell proliferation and delays tumor growth in vivo; inhibition of GIT2 Exon14 skipping reverses THRAP3-induced ferroptosis resistance. Co-immunoprecipitation (THRAP3-SLU7 interaction), alternative splicing assays, THRAP3 knockdown and overexpression, RSL3/erastin-induced ferroptosis assays, orthotopic and subcutaneous xenograft models Nature communications Medium 41326370
2026 THRAP3 knockout in C2C12 myotubes suppresses expression of myogenic regulatory factors (Myod1, Mef2c, myosin heavy chain genes), impairs myogenic differentiation and muscle fiber diameter, and attenuates T3 (triiodothyronine)-induced gene expression, establishing THRAP3 as a regulator of myogenesis and thyroid hormone-responsive gene expression in skeletal muscle. THRAP3 knockout C2C12 cells, RT-qPCR, Western blot, morphological analysis of myotube diameter, T3 stimulation assays PloS one Medium 41570000

Source papers

Stage 0 corpus · 25 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2012 Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response. Molecular cell 286 22424773
2005 Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes. Oncogene 162 15735689
2017 The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export. Nucleic acids research 87 29112714
2010 TRAP150 activates pre-mRNA splicing and promotes nuclear mRNA degradation. Nucleic acids research 62 20123736
2014 Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming. Genes & development 51 25316675
2013 THRAP3 interacts with HELZ2 and plays a novel role in adipocyte differentiation. Molecular endocrinology (Baltimore, Md.) 35 23525231
2023 Metformin attenuates multiple myeloma cell proliferation and encourages apoptosis by suppressing METTL3-mediated m6A methylation of THRAP3, RBM25, and USP4. Cell cycle (Georgetown, Tex.) 32 36762777
2021 Nuclear PD-L1 promotes cell cycle progression of BRAF-mutated colorectal cancer by inhibiting THRAP3. Cancer letters 31 34923044
2021 Thrap3 promotes R-loop resolution via interaction with methylated DDX5. Experimental & molecular medicine 28 34697388
2015 TRAP150 interacts with the RNA-binding domain of PSF and antagonizes splicing of numerous PSF-target genes in T cells. Nucleic acids research 23 26261210
2013 Btf and TRAP150 have distinct roles in regulating subcellular mRNA distribution. Nucleus (Austin, Tex.) 21 23778535
2022 Clinical Response to Venetoclax and Decitabine in Acute Promyelocytic Leukemia With a Novel RARA-THRAP3 Fusion: A Case Report. Frontiers in oncology 20 35198449
2023 Thrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy. Experimental & molecular medicine 19 37524868
2016 Phosphoproteome analysis demonstrates the potential role of THRAP3 phosphorylation in androgen-independent prostate cancer cell growth. Proteomics 19 26841317
2023 LncRNA RP4-639F20.1 interacts with THRAP3 to attenuate atherosclerosis by regulating c-FOS in vascular smooth muscle cells proliferation and migration. Atherosclerosis 12 37549548
2017 THRAP3 interacts with and inhibits the transcriptional activity of SOX9 during chondrogenesis. Journal of bone and mineral metabolism 10 28770354
2014 TRAP150 activates splicing in composite terminal exons. Nucleic acids research 10 25326322
2021 Inhibition of a Novel CLK1-THRAP3-PPARγ Axis Improves Insulin Sensitivity. Frontiers in physiology 6 34526909
2017 Alignment of Mitotic Chromosomes in Human Cells Involves SR-Like Splicing Factors Btf and TRAP150. International journal of molecular sciences 6 28895891
2024 Biological roles of THRAP3, STMN1 and GNA13 in human blood cancer cells. 3 Biotech 3 39345963
2023 Identifying and characterising Thrap3, Bclaf1 and Erh interactions using cross-linking mass spectrometry. Wellcome open research 3 35865489
2021 THRAP3 depletion reduces PPARγ mRNA and anti-inflammatory action in 3T3-L1 adipocytes. Journal of molecular endocrinology 3 34370683
2026 Functional role of THRAP3 in modulating thyroid hormone-mediated gene networks in C2C12 myotubes. PloS one 0 41570000
2026 Genetic Variants and Molecular Components Associated with Metabolic Dysfunctional-Associated Steatotic Liver Disease and Depression: Shared Association of ADAMTS7 and THRAP3. Genes 0 41898876
2025 THRAP3 promotes ferroptosis resistance in acute myelocytic leukemia through SLU7-mediated alternative splicing of GIT2. Nature communications 0 41326370

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