Affinage

SYTL1

Synaptotagmin-like protein 1 · UniProt Q8IYJ3

Length
562 aa
Mass
61.9 kDa
Annotated
2026-04-28
49 papers in source corpus 17 papers cited in narrative 17 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SYTL1 (JFC1/Slp1) is a tandem C2 domain-containing Rab27a/Rab27B effector that orchestrates vesicular trafficking, regulated exocytosis, and cell migration in hematopoietic and secretory cell types. Its C2A domain binds 3'-phosphoinositides (PI(3,4,5)P3 and PI(3,4)P2) to direct plasma membrane and secretory vesicle localization, while its SHD domain engages GTP-bound Rab27a to dock secretory granules—particularly azurophilic granules in neutrophils and zymogen granules in pancreatic acinar cells—for exocytic fusion (PMID:12189202, PMID:18939952, PMID:18477466). SYTL1 recruits the RhoA-GAP GMIP to locally inactivate RhoA and create actin-free corridors that permit granule transit through cortical actin, and independently controls directional neutrophil migration by recycling Rac1-GTP from the uropod via a Rab27a-independent interaction (PMID:22438581, PMID:30748033). SYTL1 also possesses intrinsic Mg²⁺-dependent ATPase activity, is phosphorylated by Akt at S241 causing membrane dissociation, serves as a scaffold linking Rab8a to the RabGAP EPI64 in Arf6-dependent trafficking, and its transcription is positively regulated by NF-κB and repressed by an ELK1–HDAC2 complex (PMID:11553774, PMID:15998322, PMID:22219378, PMID:12137562, PMID:36107384).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2001 High

    Identification of JFC1/SYTL1 as a novel tandem C2 domain protein that binds 3'-phosphoinositides and associates with the NADPH oxidase component p67phox established it as a PI3K-regulated adaptor in neutrophils.

    Evidence Yeast two-hybrid screen, recombinant pulldown, lipid-binding assay, and subcellular fractionation in neutrophils

    PMID:11278853

    Open questions at the time
    • Physiological significance of p67phox interaction for oxidase assembly not tested in intact cells
    • Whether JFC1 directly activates the oxidase or merely scaffolds remains unresolved
  2. 2001 High

    Demonstrating that JFC1 possesses intrinsic Mg²⁺-dependent ATPase activity with defined kinetics revealed an unexpected enzymatic function for a trafficking adaptor, distinct from known ATPase superfamilies.

    Evidence In vitro ATPase assay with recombinant protein, photoaffinity labeling with 8-azido-ATP, truncation mutagenesis

    PMID:11553774

    Open questions at the time
    • Biological role of ATPase activity in vesicular trafficking not determined
    • No structural model of the nucleotide-binding site
    • No in vivo mutagenesis of ATPase site to test functional significance
  3. 2002 High

    Mapping the C2A domain as the sole PIP3-binding and plasma membrane-targeting module, and identifying NF-κB-dependent transcriptional activation, defined both the membrane-targeting mechanism and an inflammatory signaling input for SYTL1 expression.

    Evidence Live-cell imaging of GFP-tagged domains with PI3K inhibitor, colocalization with Akt-PH domain; EMSA/supershift, luciferase reporter, and promoter mutagenesis in prostate carcinoma cells

    PMID:12137562 PMID:12189202

    Open questions at the time
    • Contribution of calcium to C2A membrane association in physiological settings not fully resolved
    • Whether NF-κB-driven upregulation is relevant in primary neutrophils versus carcinoma cells
  4. 2005 High

    Showing that Akt phosphorylates JFC1 at S241 to drive membrane dissociation, while Rab27a binding antagonizes this phosphorylation, revealed a regulatory switch coordinating PI3K signaling with Rab27a-dependent vesicle docking.

    Evidence In vitro kinase assay, mass spectrometry phosphosite mapping, S241A and W83S mutagenesis, immunofluorescence localization, PI3K inhibitor treatment

    PMID:15998322

    Open questions at the time
    • Temporal dynamics of Akt phosphorylation during stimulus-coupled exocytosis not resolved
    • No phospho-specific antibody validated in primary cells
  5. 2005 High

    Demonstrating that JFC1 selectively regulates androgen-dependent secretion of prostatic-specific acid phosphatase but not PSA in prostate cells established cargo-selective exocytic function downstream of Rab27a and PI3K.

    Evidence Dominant-negative C2A overexpression, JFC1 overexpression, immunofluorescence colocalization, secretion assay in LNCaP cells

    PMID:16004602

    Open questions at the time
    • Mechanism of cargo selectivity between PSAP and PSA granules not identified
    • Relevance to prostate physiology in vivo not tested
  6. 2008 High

    Defining JFC1 as a Rab27a effector that specifically controls azurophilic granule exocytosis in neutrophils (distinct from Munc13-4's control of gelatinase granules) and demonstrating its expression and Rab27a/Rab27B interaction in CTLs and pancreatic acinar cells broadened SYTL1's role to a general secretory granule regulator across cell types.

    Evidence siRNA knockdown and TIRF microscopy in neutrophils; Munc13-4-KO Jinx mice; co-IP and Slp1-KO mouse analysis of pancreatic zymogen granules; co-IP and localization in CTLs

    PMID:18266782 PMID:18477466 PMID:18939952

    Open questions at the time
    • Mechanism of granule subtype specificity (azurophilic vs. gelatinase) not molecularly defined
    • Slp1-KO pancreatic secretion was not functionally measured (only granule accumulation shown)
  7. 2012 High

    Identifying GMIP as a JFC1-associated RhoA-GAP that creates actin-free corridors for granule transit, and separately showing JFC1 scaffolds Rab8a for deactivation by EPI64, established JFC1 as a multi-Rab effector that coordinates actin remodeling with membrane trafficking.

    Evidence Proteomic identification of GMIP, JFC1-KO neutrophils with RhoA activity assay and live imaging; direct binding assay of JFC1–EPI64, Rab8a-GTP measurement, mutant epistasis

    PMID:22219378 PMID:22438581

    Open questions at the time
    • Whether GMIP and EPI64 pathways operate in the same cell type simultaneously is unknown
    • Structural basis of JFC1 engagement with multiple Rab partners not determined
  8. 2019 High

    Revealing that JFC1 controls Rac1-GTP recycling from the neutrophil uropod to enable directional chemotaxis—independently of Rab27a—uncovered a migration-specific function distinct from its exocytic role.

    Evidence JFC1-null mice with in vivo bone marrow chimera migration assay, co-IP of JFC1 with Rac1-GTP, STORM super-resolution microscopy

    PMID:30748033

    Open questions at the time
    • Molecular mechanism by which JFC1 extracts or recycles Rac1-GTP from uropod membranes is unknown
    • Whether other Slp-family members compensate in JFC1-null cells for migration
  9. 2022 Medium

    Identification of ELK1–HDAC2-mediated transcriptional repression of SYTL1, and WTAP/YTHDF2-mediated m6A-dependent mRNA degradation, defined two layers of negative regulation of SYTL1 expression relevant to bladder cancer.

    Evidence ChIP, co-IP, luciferase reporter for ELK1–HDAC2; RIP-qPCR and mRNA stability assay for m6A regulation

    PMID:36107384 PMID:37933909

    Open questions at the time
    • Direct functional consequence of restoring SYTL1 in bladder cancer on vesicular trafficking not tested
    • Whether these regulatory mechanisms operate in immune cells is unknown
  10. 2023 Medium

    Demonstrating that SYTL1 localizes to Anaplasma phagocytophilum inclusions via C2A-PI3P binding to deliver Rab27a+ granules for bacterial benefit, and that lincRNA01703 enhances Rab27a–SYTL1–CD81 complex formation for exosome secretion, expanded SYTL1's roles to pathogen exploitation and tumor-derived exosome biogenesis.

    Evidence shRNA knockdown, dominant-negative C2A, Nexinhib20 inhibitor in A. phagocytophilum infection model; co-IP and exosome secretion assay for lincRNA01703–Rab27a–JFC1–CD81 in lung adenocarcinoma

    PMID:38110148 PMID:38136327

    Open questions at the time
    • Whether pathogen-directed JFC1 utilization occurs in vivo during anaplasmosis is untested
    • Mechanism by which lincRNA01703 enhances ternary complex formation is unclear
  11. 2025 High

    Showing that Nexinhib20 inhibits JFC1-dependent mobilization of CD11b+ granules and β2-integrin avidity in a JFC1-dependent but Rac1-independent manner clarified that JFC1's integrin-mobilization and migration functions are mechanistically separable.

    Evidence JFC1-KO mice, Nexinhib20 treatment, quantitative 3D super-resolution microscopy, FRET-based Rac1 activity assay, flow cytometry

    PMID:39883854

    Open questions at the time
    • Precise molecular target of Nexinhib20 on JFC1 not structurally defined
    • In vivo therapeutic efficacy of Nexinhib20 in inflammatory disease models not established

Open questions

Synthesis pass · forward-looking unresolved questions
  • The biological function of JFC1's intrinsic ATPase activity, the structural basis for its engagement with multiple Rab GTPases and Rac1, and whether its trafficking and migration functions are coordinated or independently regulated in vivo remain unresolved.
  • No crystal or cryo-EM structure of full-length SYTL1 or its complexes
  • ATPase activity has no assigned in vivo function
  • Relative contributions of SYTL1 to exocytosis versus migration in immune defense in vivo not dissected

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3 GO:0008289 lipid binding 2 GO:0098772 molecular function regulator activity 2 GO:0140657 ATP-dependent activity 1
Localization
GO:0005886 plasma membrane 4 GO:0031410 cytoplasmic vesicle 4 GO:0005829 cytosol 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 6 R-HSA-162582 Signal Transduction 3 R-HSA-168256 Immune System 3
Partners
CD81GMIPNFKB1RAB27ARAB8ARAC1TBC1D10A

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 JFC1/SYTL1 was identified as a novel tandem C2 domain-containing protein that associates with p67(phox) of the leukocyte NADPH oxidase complex; JFC1 binds p67(phox) but not p47(phox) directly, acting as an adaptor between PI3K products and the oxidase cytosolic complex. JFC1 binds phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-diphosphate but not inositol 1,3,4,5-tetrakisphosphate, and is restricted to the plasma membrane/secretory vesicle fraction in neutrophils. Yeast two-hybrid screen, affinity chromatography pulldown, subcellular fractionation, lipid-binding assay The Journal of biological chemistry High 11278853
2001 JFC1/SYTL1 is an ATP-binding protein with magnesium-dependent ATPase activity; it specifically binds ATP analog 8-azido-ATP, hydrolyzes ATP and dATP with Km ~58 µM and kcat 2.27/min, and contains a nucleotide-binding site with unique characteristics distinct from GHKL ATPase/kinase superfamily. PIP3 binding does not affect ATPase kinetics. In vitro ATPase assay, photoaffinity labeling with 8-azido-[α-32P]ATP, truncation mutagenesis Proceedings of the National Academy of Sciences of the United States of America High 11553774
2002 The C2A domain of JFC1/SYTL1 is solely responsible for binding 3'-phosphorylated phosphoinositides (PIP3) and directing plasma membrane localization in living cells; the C2A domain colocalizes with the PH domain of Akt in vivo, dissociates from membrane upon PI3K inhibition, and its membrane association is modulated by calcium. Live-cell imaging with GFP-tagged domain constructs, PI3K inhibitor treatment, co-localization with Akt PH domain, lipid-binding assay Proceedings of the National Academy of Sciences of the United States of America High 12189202
2002 The JFC1/SYTL1 promoter contains three functional NF-κB binding sites; NF-κB p50 and p65 bind these sites and transactivate JFC1 expression, and TNFα upregulates JFC1 expression in prostate carcinoma cells through this NF-κB pathway. Gel retardation/EMSA, supershift assay, luciferase reporter assay, promoter mutagenesis, dominant-negative IκB expression The Biochemical journal High 12137562
2005 JFC1/SYTL1 is phosphorylated by Akt at serine 241; Akt-mediated phosphorylation of JFC1 causes its dissociation from the plasma membrane and redistribution to the cytosol without disrupting the JFC1-Rab27a interaction. JFC1 binding to Rab27a (dependent on W83 of JFC1) reduces Akt phosphorylation of JFC1. In vitro kinase assay with constitutively active Akt, mass spectrometry phosphosite identification, site-directed mutagenesis (S241A, W83S), immunoprecipitation, PI3K inhibitor (LY294002) treatment, subcellular localization by immunofluorescence Traffic (Copenhagen, Denmark) High 15998322
2005 JFC1/SYTL1 (a Rab27a- and PIP3-binding protein) regulates androgen-dependent secretion of prostatic-specific acid phosphatase (PSAP) but not PSA from LNCaP prostate cells; JFC1 co-localizes with PSAP but not PSA in prostate granules, and both Rab27a and PI3K are required for exocytosis of prostate-specific secretory markers. Dominant-negative C2A domain overexpression, JFC1 overexpression, immunofluorescence colocalization, PI3K inhibitor treatment, constitutively active Rab27aQ78L expression, secretion assay The Biochemical journal High 16004602
2008 JFC1/SYTL1 and Munc13-4 are Rab27a effectors that regulate exocytosis of distinct neutrophil granule subsets; JFC1 co-localizes with Rab27a in predocked/docked vesicles and specifically regulates azurophilic granule (myeloperoxidase) exocytosis, while Munc13-4 regulates gelatinase B (gelatinase granule) secretion. siRNA knockdown, TIRF microscopy, immunofluorescence, genetically modified mice (Munc13-4-deficient Jinx mice), secretion assay for myeloperoxidase and gelatinase B Traffic (Copenhagen, Denmark) High 18939952
2008 Slp1/JFC1 and Slp2-a are expressed in cytotoxic T lymphocytes (CTLs), both interact with Rab27a, and both localize predominantly to the plasma membrane of human and mouse CTLs. Slp2-a but not Slp1 is rapidly degraded when Rab27a is absent (due to PEST-like sequences in Slp2-a). Dominant-negative SHD of Slp2-a (56% identical to Slp1 SHD) reduces CTL killing, indicating both contribute to secretory lysosome exocytosis from CTL. Expression screening, co-immunoprecipitation with Rab27a, immunofluorescence localization in CTLs, dominant-negative overexpression, cytotoxicity assay Traffic (Copenhagen, Denmark) Medium 18266782
2008 Slp1/JFC1 is abundantly expressed in pancreatic acinar cells, interacts with Rab27B in vivo, co-localizes with Rab27B on zymogen granules, and Slp1 knockout mice show increased numbers of zymogen granules, indicating Slp1 is part of the amylase secretion machinery of the exocrine pancreas. Immunohistochemistry/immunofluorescence, co-immunoprecipitation, Slp1 knockout mouse analysis, morphological analysis Archives of biochemistry and biophysics Medium 18477466
2012 JFC1/SYTL1 associates with the RhoA-GAP protein GMIP (Gem-interacting protein); GMIP downregulation induces RhoA activation and actin polymerization that impairs vesicular transport and exocytosis. JFC1-containing secretory organelles move in actin-free areas near the plasma membrane, and JFC1-knockout neutrophils show increased RhoA activity with azurophilic granules unable to traverse cortical actin. Proteomic/mass spectrometry identification, live-cell quantitative microscopy, JFC1 knockout neutrophils, RhoA activity assay, siRNA knockdown of GMIP, actin visualization Molecular biology of the cell High 22438581
2012 EPI64 (a TBC-domain RabGAP protein) directly binds to a C-terminal region of JFC1/SYTL1; JFC1 is an effector for Rab8a, and EPI64 recruits Rab8a-GTP via JFC1 for deactivation by EPI64's RabGAP activity, thereby regulating Arf6-dependent membrane trafficking. Mutations that uncouple JFC1 from either EPI64 or Rab8-GTP disrupt vacuole formation phenotype. Co-localization, direct binding assay, mutant analysis (RabGAP-dead EPI64, JFC1 uncoupling mutants), co-expression studies, Rab8-GTP level measurement Molecular biology of the cell High 22219378
2019 JFC1/SYTL1 controls Rac1-GTP recycling from the neutrophil uropod to promote directional migration; JFC1-null neutrophils show Rac1-GTP accumulation at the uropod and impaired chemotaxis in vitro and in vivo. JFC1 interacts with Rac1-GTP in a Rab27a-independent manner at dynamic vesicles, and STORM super-resolution microscopy shows adjacent distribution of JFC1 and Rac1-GTP that increases upon activation. JFC1-null mice, live-cell microscopy, STORM super-resolution microscopy, co-immunoprecipitation (Rac1-GTP and JFC1), in vivo bone marrow chimera neutrophil migration assay, chemotaxis assay, Rac1-GTP localization analysis Journal of leukocyte biology High 30748033
2023 LincRNA01703 enhances the interaction between Rab27a, SYTL1/JFC1, and CD81 to promote secretion of CD81+ exosomes; this complex formation suppresses immune cell infiltration in the tumor microenvironment to inhibit lung adenocarcinoma metastasis. In vivo metastasis assay, co-immunoprecipitation, exosome secretion assay, lncRNA overexpression/knockdown Cancers Medium 38136327
2023 WTAP (m6A writer) promotes YTHDF2-mediated m6A methylation and degradation of SYTL1 mRNA, reducing SYTL1 protein levels in bladder cancer cells and impairing NK cell anti-tumor activity. RIP-qPCR, actinomycin D mRNA stability assay, western blot, RT-qPCR, in vivo tumor model Histology and histopathology Medium 37933909
2022 ELK1 recruits HDAC2 to the SYTL1 promoter to repress SYTL1 transcription; ELK1 and HDAC2 form a complex that specifically binds the SYTL1 promoter, suppressing SYTL1 expression and promoting bladder cancer malignant phenotype. ChIP assay, co-immunoprecipitation, luciferase reporter assay, siRNA knockdown of ELK1/HDAC2, in vitro and in vivo tumor assays Human cell Medium 36107384
2023 Rab27a effector JFC1/SYTL1 localizes to Anaplasma phagocytophilum inclusions via its C2A domain binding 3'-phosphoinositides (PI3P enriched in inclusion membrane), mediating docking/fusion of Rab27a-bearing granules with inclusions to promote bacterial proliferation; blocking Rab27a-JFC1 interaction with Nexinhib20 inhibits Anaplasma infection. shRNA knockdown, live-cell imaging, immunostaining, dominant-negative C2A domain expression, small-molecule inhibitor (Nexinhib20), infection assay Microbes and infection Medium 38110148
2025 Nexinhib20 inhibits JFC1-mediated mobilization of a subset of CD11b+ granules to the plasma membrane, reducing β2-integrin avidity; this effect is JFC1-dependent but Rac1-independent, confirmed by JFC1-KO neutrophils and direct measurement of Rac1 activation by FRET-based assay and Rac1-PAK1 binding assay. JFC1-KO mice, Nexinhib20 small-molecule inhibitor, quantitative 3D super-resolution microscopy, FRET-based Rac1 activity assay, Rac1-PAK1 binding assay, flow cytometry Journal of leukocyte biology High 39883854

Source papers

Stage 0 corpus · 49 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1998 Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint. Science (New York, N.Y.) 321 9461438
1997 Cell cycle-regulated expression, phosphorylation, and degradation of p55Cdc. A mammalian homolog of CDC20/Fizzy/slp1. The Journal of biological chemistry 120 9353311
1990 The SLP1 gene of Saccharomyces cerevisiae is essential for vacuolar morphogenesis and function. Molecular and cellular biology 111 2183024
2012 Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein. Molecular biology of the cell 83 22438581
2008 Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse. Traffic (Copenhagen, Denmark) 78 18266782
2008 The Rab27a effectors JFC1/Slp1 and Munc13-4 regulate exocytosis of neutrophil granules. Traffic (Copenhagen, Denmark) 71 18939952
1984 Plasmid formation in Streptomyces: excision and integration of the SLP1 replicon at a specific chromosomal site. Molecular & general genetics : MGG 54 6094971
2007 Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1. Molecular cell 52 18082611
2001 JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase. The Journal of biological chemistry 43 11278853
2002 The C2A domain of JFC1 binds to 3'-phosphorylated phosphoinositides and directs plasma membrane association in living cells. Proceedings of the National Academy of Sciences of the United States of America 42 12189202
1986 Structural analysis of plasmid and chromosomal loci involved in site-specific excision and integration of the SLP1 element of Streptomyces coelicolor. Journal of bacteriology 41 3011759
2005 The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase. The Biochemical journal 38 16004602
2017 Slp1-Emp65: A Guardian Factor that Protects Folding Polypeptides from Promiscuous Degradation. Cell 35 28919078
2012 Genetic analysis of Mps3 SUN domain mutants in Saccharomyces cerevisiae reveals an interaction with the SUN-like protein Slp1. G3 (Bethesda, Md.) 28 23275891
1993 Localization and nucleotide sequences of genes mediating site-specific recombination of the SLP1 element in Streptomyces lividans. Journal of bacteriology 27 8387993
2012 EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking. Molecular biology of the cell 24 22219378
2005 Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation. Traffic (Copenhagen, Denmark) 23 15998322
2011 Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeast. Molecular biology of the cell 22 21389117
1992 The chromosomal integration site for the Streptomyces plasmid SLP1 is a functional tRNA(Tyr) gene essential for cell viability. Molecular microbiology 20 1479893
1988 Analysis of recombination occurring at SLP1 att sites. Journal of bacteriology 19 3056916
2019 The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration. Journal of leukocyte biology 18 30748033
2008 Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion. Archives of biochemistry and biophysics 18 18477466
2000 High dosage expression of a zinc finger protein, Grt1, suppresses a mutant of fission yeast slp1(+), a homolog of CDC20/p55CDC/Fizzy. Journal of cell science 16 11058086
1993 Role of the imp operon of the Streptomyces coelicolor genetic element SLP1: two imp-encoded proteins interact to autoregulate imp expression and control plasmid maintenance. Journal of bacteriology 15 8226617
1989 Identification and characterization of a locus inhibiting extrachromosomal maintenance of the Streptomyces plasmid SLP1. Molecular & general genetics : MGG 15 2770697
2014 Absence of SUN-domain protein Slp1 blocks karyogamy and switches meiotic recombination and synapsis from homologs to sister chromatids. Proceedings of the National Academy of Sciences of the United States of America 14 25210014
1993 Excisive recombination of the SLP1 element in Streptomyces lividans is mediated by Int and enhanced by Xis. Journal of bacteriology 12 8387994
2023 LincRNA01703 Facilitates CD81+ Exosome Secretion to Inhibit Lung Adenocarcinoma Metastasis via the Rab27a/SYTL1/CD81 Complex. Cancers 11 38136327
2014 Investigation of metal sorption behavior of Slp1 from Lysinibacillus sphaericus JG-B53: a combined study using QCM-D, ICP-MS and AFM. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 11 25273819
2006 Different binding specificities of S-layer homology modules from Clostridium thermocellum AncA, Slp1, and Slp2. Bioscience, biotechnology, and biochemistry 11 16861798
2001 Characterization of the nucleotide-binding capacity and the ATPase activity of the PIP3-binding protein JFC1. Proceedings of the National Academy of Sciences of the United States of America 10 11553774
1998 The pufferfish SLP-1 gene, a new member of the SCL/TAL-1 family of transcription factors. Genomics 10 9503016
1998 Intracellular distribution of amino acids in an slp1 vacuole-deficient mutant of the yeast Saccharomyces cerevisiae. Journal of applied microbiology 10 9674128
2022 ELK1 suppresses SYTL1 expression by recruiting HDAC2 in bladder cancer progression. Human cell 9 36107384
2011 High-resolution genetic mapping and candidate gene identification of the SLP1 locus that controls glume development in rice. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik 9 21327937
2002 JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells. The Biochemical journal 9 12137562
2023 WTAP enhances the instability of SYTL1 mRNA caused by YTHDF2 in bladder cancer. Histology and histopathology 7 37933909
2017 Fission yeast APC/C activators Slp1 and Fzr1 sequentially trigger two consecutive nuclear divisions during meiosis. FEBS letters 7 28245054
2013 An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast. Cell cycle (Georgetown, Tex.) 7 23442800
1999 Regulation of transfer functions by the imp locus of the Streptomyces coelicolor plasmidogenic element SLP1. Journal of bacteriology 7 10498709
2012 The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γ. PloS one 6 23082202
2024 Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20Slp1 under stress. eLife 3 39412391
2022 Diploid genome assembly of Kluyveromyces marxianus NRRL Y-50883 (SLP1). G3 (Bethesda, Md.) 3 34718545
2016 A Novel Insecticidal Peptide SLP1 Produced by Streptomyces laindensis H008 against Lipaphis erysimi. Molecules (Basel, Switzerland) 3 27556442
2023 Rab27a via its effector JFC1 localizes to Anaplasma inclusions and promotes Anaplasma proliferation in leukocytes. Microbes and infection 2 38110148
2016 Au-Interaction of Slp1 Polymers and Monolayer from Lysinibacillus sphaericus JG-B53 - QCM-D, ICP-MS and AFM as Tools for Biomolecule-metal Studies. Journal of visualized experiments : JoVE 2 26863150
2026 Lipidomic profiling of Arabidopsis chloroplast protein phosphatase SLP1 mutants reveals altered diurnal lipid remodeling. BBA advances 0 41607683
2026 Functional FTSH4 Complexes In Arabidopsis Mitochondria: A Megacomplex with SLP1 and SLP1-free Smaller Complexes. Plant & cell physiology 0 41711086
2025 Nexinhib20 inhibits JFC1-mediated mobilization of a subset of CD11b/CD18+ vesicles decreasing integrin avidity, but does not inhibit Rac1. Journal of leukocyte biology 0 39883854