Affinage

SPN

Leukosialin · UniProt P16150

Length
400 aa
Mass
40.3 kDa
Annotated
2026-06-10
100 papers in source corpus 43 papers cited in narrative 43 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/8 claims corpus-supported (88%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SPN (CD43/leukosialin) is a heavily O-glycosylated transmembrane sialomucin—~52% carbohydrate by weight with mucin-like proline/serine/threonine-rich structure (PMID:3711098)—that operates on hematopoietic cells as a dual adhesion-regulatory and signaling molecule. Its large sialylated ectodomain interferes with LFA-1–ICAM-1 adhesion in a sialic acid-dependent manner (PMID:1594606), yet CD43 itself binds ICAM-1 as a counterreceptor (PMID:1683685) and serves as a ligand for sialoadhesin/Siglec-1 (PMID:11238599) and M-ficolin (PMID:22167719). Genetic deletion establishes CD43 as a net negative regulator of T-cell activation and adhesion (PMID:7566153), and structure-function reconstitution localized this negative regulation to its cytoplasmic tail rather than steric hindrance, requiring exclusion of the intracellular region from the immunological synapse (PMID:15117976, PMID:9862667). Beyond this restraint, CD43 cross-linking transduces CD3-independent activation signals: it engages Fyn through SH3 binding to a proline-rich cytoplasmic motif (PMID:8910342), recruits and phosphorylates the ζ-chain in an Lck-dependent manner to dock ZAP-70 and Vav (PMID:12902492), triggers PLC/Ca2+/PKC signaling (PMID:2542404), assembles Shc/GRB2/Vav complexes driving ERK activation (PMID:9603925), and induces NF-AT, AP-1, and NF-κB to costimulate IL-2 and activation-marker expression independently of CD28 (PMID:10908570, PMID:7790813). Cytoplasmic Ser76, phosphorylated by PKCθ, governs ERM-dependent trafficking to the distal pole and lymph node homing (PMID:17638845, PMID:21289089). Specific glycoforms tune its ligand activity: C2GnT-generated core 2 O-glycans (PMID:9061371) create E-selectin ligand activity for T-cell rolling and tissue recruitment, including a dominant role in Th17 migration (PMID:16339541, PMID:26700769), while both core 1 and core 2 forms bind galectin-1 to mediate T-cell apoptosis and dendritic-cell activation (PMID:17015718, PMID:19635795). After ectodomain shedding, γ-secretase liberates the SUMO-1–modified cytoplasmic tail, which translocates to PML nuclear bodies to promote cell survival (PMID:19696198). Virion-incorporated CD43 coclusters with assembling HIV-1 Gag through polybasic cytoplasmic-tail motifs and impairs virion infectivity by blocking virus attachment (PMID:25320329, PMID:32193343).

Mechanistic history

Synthesis pass · year-by-year structured walk · 18 steps
  1. 1986 High

    Established the biochemical nature of CD43 as a mucin-type sialoglycoprotein, defining the structural basis for its later anti-adhesive and ligand functions.

    Evidence Sequential lectin affinity purification with amino acid and carbohydrate composition analysis

    PMID:3711098

    Open questions at the time
    • Did not assign function to the glycan-rich ectodomain
    • No connection yet to signaling or adhesion
  2. 1989 Medium

    Showed CD43 is dynamically phosphorylated and couples to PLC signaling, the first evidence it is an active signaling molecule rather than a passive coat.

    Evidence 32P metabolic labeling of CD43; phosphoinositide hydrolysis, PKC translocation and Ca2+ assays in T cells and monocytes with CD3-independence control

    PMID:2531463 PMID:2542404

    Open questions at the time
    • Kinase responsible for serine phosphorylation not identified
    • Receptor proximal coupling to PLC not mapped
  3. 1991 High

    Defined CD43 as both an ICAM-1 counterreceptor and a costimulatory molecule whose intracellular domain is needed for T-cell activation, framing it as an adhesion-coupled signaling receptor.

    Evidence Cell binding to purified immobilized CD43 with antibody/liposome inhibition; cDNA and cytoplasmic-domain mutant transfection of T-cell hybridoma

    PMID:1683685 PMID:2023632

    Open questions at the time
    • Physiological relevance versus net negative regulation unresolved
    • Cytoplasmic effectors unidentified
  4. 1992 High

    Demonstrated the ectodomain's anti-adhesive barrier function is sialic acid-dependent, explaining how a glycan-rich surface molecule restrains integrin-mediated adhesion.

    Evidence T-lymphocyte adhesion to CD43-transfected HeLa cells with neuraminidase treatment and antibody blocking

    PMID:1594606

    Open questions at the time
    • Did not distinguish steric versus intracellular mechanisms (resolved in 2004)
  5. 1995 High

    Genetic deletion revealed CD43's dominant physiological role is negative regulation of T-cell activation and adhesion, reconciling its conflicting costimulatory and anti-adhesive activities.

    Evidence CD43-knockout mice with proliferation, adhesion, and viral infection assays; expression cloning and CD28-independent costimulation in CD28-deficient mice

    PMID:7566153 PMID:7790813

    Open questions at the time
    • Mechanism of negative regulation (steric vs signaling) not yet defined
    • Glycoform dependence of phenotypes untested
  6. 1996 High

    Identified the Fyn-SH3/proline-rich-tail interaction and apoptotic signaling, providing the molecular link between CD43 cross-linking and downstream tyrosine kinase activation.

    Evidence GST-Fyn SH3 pulldown, peptide competition and co-IP; J393 hyposialylated-isoform apoptosis assays with kinase/phosphatase inhibitors

    PMID:8910342 PMID:8910360

    Open questions at the time
    • How clustering selects activation vs apoptosis outcome unclear
    • Glycoform that licenses apoptosis not molecularly defined
  7. 1998 High

    Mapped the proximal-to-distal signaling cascade (Shc/GRB2/Vav, ERK) and established antigen-dependent CD43 exclusion from the synapse, connecting CD43 to MAPK-driven IL-2 expression and synapse architecture.

    Evidence Co-IP of Shc/GRB2/Vav complexes, ERK2 kinase and SRE reporter assays; fluorescence imaging of T cell–APC conjugates

    PMID:9603925 PMID:9862667

    Open questions at the time
    • Functional consequence of synapse exclusion not yet tested
    • Link between exclusion and negative regulation unestablished
  8. 1999 Medium

    Extended CD43 signaling and trafficking functions across cell types—cytoskeletal capping in neutrophils, NK chemokine release via PYK-2, and lymph node homing—showing it is a general leukocyte polarization and trafficking regulator.

    Evidence Triton solubility and imaging with cytochalasin/BDM in neutrophils; chemokine ELISA and PYK-2 kinase assay in NK cells; HEV binding and in vivo trafficking with mAb L11

    PMID:10339479 PMID:10515880 PMID:9126930 PMID:9224764

    Open questions at the time
    • Direct cytoskeletal adaptor not identified at this stage
    • Homing ligand on HEV not molecularly defined
  9. 2001 High

    Identified sialoadhesin (Siglec-1) as a CD43 counterreceptor and showed CD43 cross-linking matures dendritic cells, broadening its ligand repertoire and innate-immune roles.

    Evidence Sialoadhesin-Fc pulldown, COS-cell binding reconstitution with Siglec-1 R97A mutant and defined glycoforms; F(ab')2 vs Fab DC maturation assays

    PMID:10352244 PMID:11238599

    Open questions at the time
    • In vivo relevance of CD43-sialoadhesin contact not established
    • DC signaling effectors only partly defined
  10. 2003 High

    Resolved the proximal signaling module by showing CD43 recruits and phosphorylates the ζ-chain in an Lck-dependent manner, explaining how a non-TCR receptor co-opts TCR signaling machinery.

    Evidence Co-IP, in vitro kinase assay, ζ-chain imaging and Lck-deficient JCaM.1 cells; pharmacological dissection of homotypic aggregation pathway

    PMID:12902492 PMID:12972508

    Open questions at the time
    • Stoichiometry and basis of ζ-chain recruitment unresolved
    • How CD43 signaling integrates with TCR remains unclear
  11. 2004 High

    Showed CD43 negative regulation operates through its intracellular domain and synapse exclusion, not the ectodomain steric barrier, redefining the mechanism of its restraint on T cells.

    Evidence Reconstitution of GPI-linked ectodomain, intracellular-only chimera, and ERM-binding mutants in CD43-/- T cells with proliferation and IL-2 readouts

    PMID:15117976

    Open questions at the time
    • Identity of intracellular negative effector not defined
    • Mechanism linking synapse exclusion to IL-2 control incomplete
  12. 2005 High

    Defined CD43 core 2 glycoforms as E-selectin ligands enabling rolling, and confirmed sialomucin anti-adhesive roles in mast cells, linking specific glycosylation to vascular recruitment.

    Evidence E-selectin-Fc pulldown and CHO reconstitution with FucT-VII/C2GnT in flow chamber; CD34/CD43 double-KO mast cell aggregation and in vivo reconstitution

    PMID:15664158 PMID:16339541

    Open questions at the time
    • Relative contribution versus PSGL-1 not yet quantified
    • In vivo rolling not yet demonstrated
  13. 2006 High

    Established CD43 (core 1 or core 2 glycoforms) as a galectin-1 receptor mediating T-cell death, defining a glycan-dependent pro-apoptotic axis distinct from E-selectin binding.

    Evidence CD43-deficient T cells, defined-glycoform fusion proteins, galectin-1 binding/death assays and clustering microscopy

    PMID:17015718

    Open questions at the time
    • Downstream death signaling from CD43 clustering not mapped
  14. 2007 High

    Mapped Ser76 phosphorylation as the trafficking-specific signal and showed CD43 collaborates additively with PSGL-1 for E-selectin-dependent skin homing, separating trafficking from synapse and proliferation functions.

    Evidence Mass-spectrometry identification of phospho-Ser76 and S76A reconstitution with lymph node trafficking; CD43-/- and PSGL-1-/- double-KO Th1 migration to inflamed skin

    PMID:17277158 PMID:17638845

    Open questions at the time
    • Kinase for Ser76 not identified at this stage (resolved 2011)
    • Adaptor reading the phospho-tail unknown
  15. 2009 High

    Revealed regulated intramembrane proteolysis releases a SUMO-1–modified CD43 tail to PML nuclear bodies to promote survival, and showed galectin-1 co-clusters CD43/CD45 to activate DC signaling, extending CD43 function into the nucleus and innate activation.

    Evidence TMD chimeras, γ-secretase inhibitor, nuclear fractionation, SUMO-1 and PML colocalization; kinome screen with Syk/PKC inhibitors and co-cluster imaging in DCs

    PMID:19635795 PMID:19696198

    Open questions at the time
    • Nuclear transcriptional targets of CD43 tail unidentified
    • Sheddase generating the CD43 stub not defined
  16. 2011 High

    Identified PKCθ as the Ser76 kinase and ERM association as its prerequisite, completing the trafficking signaling module that drives CD43 to the distal pole complex.

    Evidence Phospho-specific antibody, S76A/S76D reconstitution, ERM co-IP, PKCθ kinase assay, migration assays; M-ficolin sialic-acid-dependent binding and functional phenocopy on neutrophils

    PMID:21289089 PMID:22167719

    Open questions at the time
    • How ERM binding gates PKCθ access to Ser76 not mechanistically resolved
  17. 2015 High

    Established CD43 as the dominant, PSGL-1-independent E-selectin ligand in Th17 cells with disease-level consequences, defining a context-specific function in autoimmune recruitment.

    Evidence Flow chamber with PSGL-1-/-, CD43-/-, double-KO Th17 cells; intravital microscopy and EAE model

    PMID:26700769

    Open questions at the time
    • Glycosyltransferase basis of Th17-specific glycoform not defined
    • Why CD43 dominates over PSGL-1 in Th17 unexplained
  18. 2020 High

    Defined an antiviral function: virion-incorporated CD43 coclusters with HIV-1 Gag via polybasic tail motifs and blocks virus attachment, repurposing its adhesion-modulating ectodomain against infection.

    Evidence Superresolution Gag coclustering with tail-swap mutants; virion infectivity and attachment assays with Env-deleted controls and full-length vs truncated constructs

    PMID:25320329 PMID:32193343

    Open questions at the time
    • Full-length ectodomain requirement shown directly for PSGL-1, inferred for CD43
    • Physiological impact on HIV transmission in vivo untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How CD43 integrates its opposing activities—negative regulation versus costimulation, survival versus apoptosis—into a single context-dependent decision, and the identity of the nuclear effectors of the released cytoplasmic tail, remain unresolved.
  • No unifying model connecting glycoform, clustering state, and signaling outcome
  • Transcriptional program controlled by the nuclear CD43 tail unknown
  • Sheddase generating the substrate for γ-secretase unidentified

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060089 molecular transducer activity 5 GO:0098631 cell adhesion mediator activity 4 GO:0008092 cytoskeletal protein binding 2
Localization
GO:0005886 plasma membrane 4 GO:0005856 cytoskeleton 2 GO:0005634 nucleus 1
Pathway
R-HSA-168256 Immune System 5 R-HSA-1500931 Cell-Cell communication 4 R-HSA-162582 Signal Transduction 4 R-HSA-5357801 Programmed Cell Death 3
Partners
CD3ZEZRFYNICAM1LCKLGALS1SELESIGLEC1

Evidence

Reading pass · 43 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1991 CD43 binds ICAM-1 (CD54) as a ligand, demonstrated by specific binding of Daudi cells to purified immobilized CD43 and inhibition by anti-CD43 antibodies and CD43-containing liposomes; expression of human CD43 in a murine T-cell hybridoma enhanced antigen-specific T-cell activation. Cell binding assay with purified immobilized CD43, inhibition with anti-CD43 mAb and CD43-liposomes, T-cell hybridoma transfection Nature High 1683685
1991 CD43-mediated T-cell activation requires its intracellular domain (which is hyperphosphorylated during activation); expression of CD43 cDNA in antigen-responsive murine T-cell hybridoma enhanced antigen-specific activation; antigen-presenting cells bind specifically to immobilized purified CD43. cDNA transfection of CD43 and cytoplasmic domain mutants into T-cell hybridoma, purified CD43 binding assay Nature High 2023632
1992 CD43 expressed on opposing cells interferes with T-cell LFA-1 binding to ICAM-1; this anti-adhesive effect is dependent on sialic acid residues on CD43, as neuraminidase treatment of CD43-positive HeLa cells diminished the effect. T-lymphocyte adhesion assay to CD43-transfected HeLa cells; antibody blocking; neuraminidase treatment Proceedings of the National Academy of Sciences of the United States of America High 1594606
1989 CD43 engagement activates phospholipase C signaling pathway in T cells and monocytes: anti-CD43 mAb L10 induced phosphoinositide hydrolysis, generating diacylglycerol and inositol phosphates, PKC translocation from cytosol to membrane, and increased intracellular Ca2+; CD43 signaling proceeds independently of TCR/CD3. Phosphoinositide hydrolysis assay, PKC translocation assay, intracellular Ca2+ measurement in PBMC, T cells, monocytes, and leukemic T cell lines Journal of immunology (Baltimore, Md. : 1950) High 2542404
1995 CD43-deficient mice show enhanced T-cell proliferation, increased homotypic adhesion, and increased ICAM-1 and fibronectin binding, demonstrating that CD43 negatively regulates T-cell activation and adhesion; CD43-knockout mice also showed augmented anti-vaccinia CTL response but increased viral load. CD43-knockout mouse generation, in vitro proliferation assays (ConA, anti-CD3, SEB, allostimulation), adhesion assays, viral infection model Nature High 7566153
1995 CD43 functions as a CD28-independent costimulatory receptor on murine T cells; expression cloning identified murine CD43 as the antigen for mAb R2/60, which synergizes with TCR engagement to induce T-cell proliferation independently of CD28. Expression cloning, T-cell proliferation assay with anti-CD43 mAb in CD28-deficient mice The Journal of experimental medicine High 7790813
1996 CD43 cross-linking induces association of CD43 with Fyn kinase via Fyn's SH3 domain binding to a proline-rich sequence (300ERQPAPALPPKPPKP314) in CD43's cytoplasmic tail; CD43 cross-linking also results in Fyn tyrosine phosphorylation. Co-immunoprecipitation, GST-Fyn SH3 pulldown from T-cell lysates, synthetic peptide competition assay, tyrosine phosphorylation assay The Journal of biological chemistry High 8910342
1998 CD43 cross-linking in human T lymphocytes induces tyrosine phosphorylation of Shc and Vav, formation of a Shc/GRB2/Vav complex, enhanced Vav-SLP-76 complex formation, and ERK2 activation and nuclear translocation; CD43-mediated signals activate the MAP kinase pathway leading to IL-2 gene expression. Co-immunoprecipitation, tyrosine phosphorylation assay, luciferase reporter assay (Fos SRE), ERK2 kinase activation assay The Journal of biological chemistry High 9603925
1998 CD43 is actively excluded from the T cell–APC contact site in an antigen-dependent manner; CD3 signaling alone can induce this exclusion. CD45 is not excluded, indicating this is a specific property of CD43. Fluorescence microscopy of T cell–APC conjugates Journal of immunology (Baltimore, Md. : 1950) Medium 9862667
1999 Crosslinking CD34 or CD43 on immature hematopoietic KG1a cells activates the same signaling pathway (Lyn, Syk, and novel tyrosine-phosphorylated proteins) leading to cytoadhesion; cap formation of CD34 or CD43 colocalizes with F-actin, and cap formation is required for Syk and pp77 phosphorylation and cytoadhesion (blocked by cytochalasin D). Co-immunoprecipitation, cytochalasin D inhibition, anti-phosphotyrosine Western blot, immunofluorescence Blood Medium 10339479
1996 CD43 ligation of a hyposialylated CD43 isoform (recognized by mAb J393) on Jurkat T cells induces apoptosis via tyrosine kinase activation; herbimycin A diminished apoptosis and phosphatase inhibitor enhanced it; CD43-mediated apoptosis is potentiated by co-engagement of CD3/TCR or integrins CD18/CD29; apoptosis is associated with decreased nuclear NF-κB. Apoptosis assay, tyrosine phosphorylation assay, kinase/phosphatase inhibitor treatment, NF-κB nuclear localization The Journal of biological chemistry Medium 8910360
2000 CD43 ligation on normal peripheral human T cells is sufficient to induce IL-2, CD69, and CD40-L gene expression and activate NF-AT, AP-1 (c-Jun containing), and NF-κB (p65) transcription factors; this is partially inhibited by cyclosporin A (Ca2+ pathway) and staurosporine (PKC pathway). EMSA for transcription factor DNA binding, cytokine/activation marker expression assays, pharmacological inhibition The Journal of biological chemistry Medium 10908570
2001 CD43 is a T cell counterreceptor for sialoadhesin (Siglec-1) on macrophages; CD43 expressed in COS cells supports increased binding to immobilized sialoadhesin; binding is sialic acid-dependent and requires Arg97 in the sialoadhesin binding site; both core 1 and core 2 O-glycan forms of CD43 support binding. Sialoadhesin-Fc pulldown/precipitation from T-cell lysates, COS cell expression with sialoadhesin binding assay, Siglec-1 R97A mutant, CHO cells expressing defined CD43 glycoforms Journal of immunology (Baltimore, Md. : 1950) High 11238599
2001 CD43 mediates dendritic cell maturation upon cross-linking: anti-CD43 F(ab')2 (but not monovalent Fab) induced upregulation of HLA-DR, CD54, CD40, CD80, CD86, CD83, cytokine release (IL-1β, IL-6, TNF-α, IL-12, IL-10), intracellular Ca2+ rise, and tyrosine phosphorylation of a 25-kDa protein in dendritic cells. Flow cytometry for surface marker upregulation, ELISA for cytokines, Ca2+ flux assay, tyrosine phosphorylation assay; comparison of intact Ab vs F(ab')2 vs Fab Journal of immunology (Baltimore, Md. : 1950) Medium 10352244
2002 hnRNP-K and Purα act together to repress transcriptional activity of the CD43 gene promoter during activation of K562 cells; these proteins bind single-stranded DNA sequences in the CD43 promoter; CD43 mRNA levels are dramatically downregulated during K562 activation, coinciding with promoter repression. Transcriptional reporter assay, RT-PCR for CD43 mRNA, identification of hnRNP-K and Purα as promoter-binding repressors Blood Medium 12411317
2002 CD43 distribution on T cells is regulated by a membrane-proximal ezrin-binding site; failure to displace CD43 from the immunological synapse does not inhibit primary T cell activation, but CD43 expression at T cell–matrix contact does not negatively regulate motility while it may regulate LFA-1 de-adhesion. Fluorescence microscopy with CD43 mutants lacking ezrin-binding site, T-cell activation and motility assays Journal of immunology (Baltimore, Md. : 1950) Medium 11937524
2003 CD43 recruits the ζ-chain as part of its signaling pathway in human T lymphocytes and NK cells; CD43 engagement leads to ζ-chain tyrosine phosphorylation creating docking sites for ZAP-70 and Vav; Lck is required for ζ-chain phosphorylation downstream of CD43; CD43 engagement concentrates the ζ-chain toward the bead attachment site. Co-immunoprecipitation, in vitro kinase assay, ζ-chain redistribution imaging, Lck-deficient JCaM.1 cell experiments Journal of immunology (Baltimore, Md. : 1950) High 12902492
2004 CD43 negative regulation of T-cell activation operates through an intracellular mechanism, not steric hindrance: a GPI-linked CD43 ectodomain construct failed to reverse CD43−/− T-cell hyperproliferation; an intracellular-only CD43 (small ectodomain of hCD16 fused to CD43 cytoplasmic tail) reversed hyperproliferation; exclusion of the CD43 intracellular region from the immunological synapse is required for regulation of IL-2 production. Reconstitution of CD43 mutants (GPI-linked ectodomain, intracellular-only chimera, ERM-binding mutant) in CD43−/− T cells; proliferation and IL-2 production assays The Journal of experimental medicine High 15117976
2005 CD43 functions as an E-selectin ligand on activated T cells; a 130-kDa glycoform of CD43 is precipitated by E-selectin-IgG chimera from Th1 cells in a sialic acid-dependent manner; CD43-IgG chimera generated in CHO cells expressing FucT-VII and C2GnT supports E-selectin-dependent cell rolling under flow conditions. E-selectin-IgG pulldown/immunoprecipitation, O-sialoglycoprotein endopeptidase treatment, mAb 1B11 identification, CHO cell reconstitution with defined glycosyltransferases, flow chamber rolling assay Journal of immunology (Baltimore, Md. : 1950) High 16339541
2005 CD34 and CD43 act as negative regulators of mast cell adhesion; loss of CD43 and/or CD34 causes gene-dose-dependent increase in mast cell homotypic aggregation; reexpression of CD34 or CD43 reverses this phenotype; loss of these sialomucins also prevents mast cell repopulation in vivo. CD34/CD43 double-KO mouse mast cell analysis, re-expression rescue experiments, in vitro aggregation assay, in vivo reconstitution Immunity High 15664158
2006 CD43 bearing either core 1 or core 2 O-glycans binds galectin-1 and is required for maximal T-cell susceptibility to galectin-1-induced death; galectin-1 binding clusters CD43 on the T-cell surface; loss of CD43 reduced galectin-1-induced death and galectin-1 binding by ~50%. CD43-deficient T cells, galectin-1 binding assay, galectin-1 death assay, CD43 fusion proteins with defined glycoforms (core 1 vs core 2), microscopy for CD43 clustering Journal of immunology (Baltimore, Md. : 1950) High 17015718
2007 CD43 collaborates with PSGL-1 to mediate E-selectin-dependent T-cell migration into inflamed skin in vivo; CD43-deficient Th1 cells showed reduced E-selectin-binding activity; PSGL-1/CD43 double-deficient Th1 cells show the most profound decrease, demonstrating additive roles. CD43−/− and PSGL-1−/− mice, E-selectin binding assay, in vivo adoptive transfer migration assay to inflamed skin Journal of immunology (Baltimore, Md. : 1950) High 17277158
2007 CD43 regulates T-cell trafficking through phosphorylation at Ser76 in its cytoplasmic tail; mutation of Ser76 to alanine greatly diminishes T-cell trafficking to the lymph node while leaving CD43 exclusion from the synapse and CD43-mediated regulation of T-cell proliferation intact; the CD43 extracellular domain is also required for trafficking. Tandem mass spectrometry identification of phospho-Ser76, CD43 Ser76Ala mutant reconstitution in CD43−/− T cells, lymph node trafficking assay Blood High 17638845
2009 Galectin-1 binds CD43 and CD45 on dendritic cells, inducing unipolar co-clustering of these receptors; galectin-1 activates Syk and PKC signaling in DCs, with phosphorylated Syk recruited to the CD43/CD45 co-cluster; Syk and PKC inhibitors abrogate galectin-1-induced DC activation, IL-6 production, MMP gene upregulation, and enhanced migration. Kinome screen, Syk phosphorylation assay, co-cluster imaging, PKC/Syk inhibitors, cytokine ELISA, migration assay, in vivo intradermal injection The Journal of biological chemistry High 19635795
2009 The CD43 ectodomain is shed from granulocytes, mast cells, and T cells (but not macrophages); after γ-secretase cleavage, the CD43 cytoplasmic tail (CD43ct) translocates to the nucleus; inhibition of nuclear translocation or γ-secretase cleavage is proapoptotic; CD43ct is modified by SUMO-1 and colocalizes with promyelocytic nuclear bodies; CD43-deficient cells show reduced PML nuclear bodies and increased sensitivity to apoptosis. CD43/CD34 transmembrane-domain chimeras, viability assays, nuclear fractionation, SUMO-1 modification assay, γ-secretase inhibitor, PML nuclear body colocalization imaging Blood High 19696198
2011 CD43 interaction with ERM proteins is required for CD43 phosphorylation at Ser76; mutation of Ser76 to a phosphomimetic (S76D) enhances T-cell migration and CD43 movement to the distal pole complex while blocking ERM association; protein kinase Cθ can phosphorylate CD43 at Ser76. Phospho-specific antibody, CD43 Ser76 mutants (S76A, S76D) reconstitution in CD43−/− T cells, migration assay, ERM co-immunoprecipitation, PKCθ kinase assay Molecular biology of the cell High 21289089
2015 CD43 is a dominant E-selectin ligand specifically in Th17 cells, functioning independently of PSGL-1; CD43-deficient Th17 cells show impaired accumulation on E-selectin under flow and impaired rolling on TNF-α-treated microvessels in vivo; CD43−/− mice are protected from EAE with impaired Th17 cell recruitment to spinal cord. Flow chamber E-selectin binding assay with PSGL-1−/−, CD43−/−, and double-KO Th17 cells; intravital microscopy; in vivo air pouch recruitment; EAE model Journal of immunology (Baltimore, Md. : 1950) High 26700769
2020 Virion-incorporated CD43 (and PSGL-1) inhibit HIV-1 cell-free infection and transinfection by preventing virus attachment to CD4+ cells and CD4− fibroblastic reticular cells, irrespective of Env; the inhibitory effect requires the full-length ectodomain (demonstrated for PSGL-1); CD43 and PSGL-1 cocluster with assembling HIV-1 Gag at the plasma membrane. Virion infectivity assay, virus attachment assay (CD4+ and CD4− cells), Env-deleted virus controls, full-length vs truncated PSGL-1 constructs, Gag coclustering imaging Proceedings of the National Academy of Sciences of the United States of America High 32193343
2014 CD43 coclusters with assembling HIV-1 Gag at the plasma membrane through polybasic motifs in the CD43 cytoplasmic tail and in the Gag matrix domain; mutation of the polybasic sequence in CD43 cytoplasmic tail reduces its coclustering with Gag; replacement of cytoplasmic tails of non-coclustering proteins with CD43/PSGL-1 tails confers coclustering. Quantitative two-color superresolution localization microscopy, Gag matrix domain basic residue mutants, chimeric transmembrane protein tail-swap constructs Journal of virology High 25320329
1997 CD43 associates with the cytoskeleton in neutrophils via F-actin; anti-CD43 crosslinking induces CD43 redistribution to caps at the uropod, dependent on the actomyosin system (blocked by cytochalasin B and butanedione monoxime); colchicine and chemotactic factor fNLP also drive CD43 redistribution to the uropod independently of mAb crosslinking, suggesting CD43 is involved in cell polarization. Triton X-100 solubility assay for cytoskeletal association, immunofluorescence, electron microscopy, cytochalasin B and BDM inhibition Journal of cell science Medium 9224764
1997 Core 2 N-acetylglucosaminyltransferase (C2GnT) modifies CD43 O-glycans, converting the 115-kDa (core 1, S7 epitope) glycoform to the 130-kDa (core 2, 1B11 epitope) glycoform; transfection of C2GnT into EL-4 cells caused gain of 1B11 epitope and loss of S7 epitope, with ~10 kDa molecular weight increase. C2GnT transfection into EL-4 cells, flow cytometry with S7 and 1B11 antibodies, SDS-PAGE molecular weight analysis Glycobiology Medium 9061371
1999 CD43 expression on T cells mediates T-cell homing to lymph nodes and Peyer's patches; anti-CD43 mAb L11 blocks T-cell binding to HEV in vitro and inhibits T-cell extravasation from blood into lymphoid tissues in vivo, without affecting binding to purified vascular ligands for L-selectin, α4β7, or LFA-1. HEV binding assay in vitro, in vivo lymphocyte trafficking assay, antibody blocking with selectin/integrin panel The Journal of experimental medicine Medium 9126930
1999 CD43 ligation on T cells induces the CD43-Fyn interaction and mediates homotypic aggregation requiring CD43 association with cytoskeleton; the CD43 signaling pathway leading to Ca2+ mobilization and IL-2 production involves Shc, GRB2, Vav, and ERK2 activation. Referenced from 1996 and 1998 papers; reviewed in context of T-cell activation Immunologic research Low 10580634
2003 CD43-mediated homotypic aggregation of T lymphocytes requires Src kinases, PLCγ2, PKC, PI3K, ERK1/2, and p38; these signaling molecules regulate actin cytoskeleton remodeling after CD43 ligation; leflunomide blocks Src kinase target recruitment and actin polymerization downstream of CD43, diminishing aggregation. Pharmacological inhibitors of Src, PLCγ, PKC, PI3K, ERK, p38; F-actin staining; leflunomide treatment; homotypic aggregation assay Journal of leukocyte biology Medium 12972508
2001 CD43-mediated apoptosis in TF-1 myeloid progenitor cells involves repression of AP-1 DNA binding activity and downregulation of 14-3-3 proteins and GM-CSF receptor β; this is followed by translocation of proapoptotic Bad to mitochondria; Daxx overexpression inhibits CD43-mediated apoptosis; co-immobilized anti-ICAM-3/CD99 partly suppress apoptosis. Immobilized anti-CD43 mAb apoptosis assay, DNA array screening, AP-1 EMSA, Bad localization assay, Daxx overexpression The Journal of biological chemistry Medium 11773067
2011 M-ficolin binds to CD43 on neutrophils in a sialic acid-dependent manner (Y271F mutant unable to bind sialic acid fails to bind neutrophils or modulate their functions); endogenous M-ficolin secreted by fMLP-activated neutrophils binds to CD43; M-ficolin binding induces cell polarization, adhesion, and homotypic aggregation, phenocopying anti-CD43 antibody crosslinking. Recombinant M-ficolin binding assay with blocking anti-CD43 mAb, Western blot of neutrophil lysate with rM-ficolin, Y271F sialic-acid-binding mutant, immunofluorescence colocalization, functional adhesion/aggregation assay Journal of leukocyte biology High 22167719
1999 CD43 ligation on NK cells induces secretion of RANTES, MIP-1α, and MIP-1β chemokines (blocked by tyrosine kinase inhibitor genistein); increases cytotoxic activity; and activates PYK-2 tyrosine kinase. ELISA for chemokines, cytotoxicity assay, anti-phosphotyrosine immunoprecipitation, PYK-2 kinase assay, genistein inhibition Blood Medium 10515880
2021 MSC-derived ICAM-1 interacts with CD43 on activated T cells; blockade of either ICAM-1 on MSCs or CD43 on T cells reversed rapid suppression of proinflammatory cytokine (TNF-α, IFN-γ) mRNA expression; ICAM-1/CD43 interaction disrupts CD43-mediated TCR microcluster formation to limit T-cell activation, and suppresses TCR-proximal signaling and Ca2+ flux. ICAM-1 and CD43 blocking antibodies in MSC-T cell coculture; cytokine mRNA quantification; TCR microcluster imaging; Ca2+ signaling assay Frontiers in immunology Medium 33692786
2008 CD43 regulates Th2 differentiation; CD43−/− T cells show decreased calcium flux upon TCR ligation and preferentially differentiate into Th2 cells in vitro, associated with increased GATA-3 nuclear translocation; CD43−/− mice exhibit increased Th2-mediated allergic airway inflammation in vivo. CD43−/− T cells, Ca2+ flux assay, Th1/Th2 differentiation protocol, GATA-3 nuclear translocation assay, allergic airway disease model Journal of immunology (Baltimore, Md. : 1950) Medium 18490738
2004 CD43 expressed by cancer cell lines (PSN-1, SW1222) mediates adhesion to human peritoneal mesothelial cells (HPMC) via interaction with ICAM-1; anti-CD43 antibody significantly reduced tumor cell adhesion to HPMC; β2 integrin inhibition did not reduce this adhesion. Western blot and flow cytometry for CD43 expression, fluorometric adhesion assay with inhibitory anti-CD43 antibody vs anti-β2 integrin antibody Biological chemistry Medium 15449712
1989 CD43 is rapidly superphosphorylated on serine residues within minutes of phorbol ester (PMA) treatment of lymphocytes; ConA and anti-CD3 also cause CD43 superphosphorylation, albeit delayed; CD43 is constitutively superphosphorylated on serine and tyrosine in continuously growing T, B, and non-lymphoid cell lines. Metabolic radiolabeling with 32P, immunoprecipitation of CD43, SDS-PAGE Scandinavian journal of immunology Medium 2531463
1986 gpL115 (CD43) is a heavily glycosylated transmembrane sialoglycoprotein; purification established that it is 52% carbohydrate by weight (asialo form), with major O-linked carbohydrate residues being galactose and N-acetylgalactosamine in equimolar amounts; amino acid composition shows high proline and serine/threonine content typical of mucin-like proteins. Sequential affinity chromatography purification (lentil lectin, wheat germ lectin, peanut lectin Sepharose), amino acid composition analysis, carbohydrate analysis The Journal of biological chemistry High 3711098
2019 CD43 functions as an E-selectin ligand on PSGL-1-deficient lymphoblasts; knockdown of CD43 on NALL-1 B-precursor ALL cells resulted in reduced rolling on E-selectin and decreased tissue engraftment in immunodeficient mice. Flow adhesion assay, E-selectin binding, RNA interference knockdown of CD43, xenograft engraftment assay in irradiated immunodeficient mice Cancers Medium 31461905

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures. Blood 281 16757688
1991 CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1. Nature 270 1683685
2001 Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN. The EMBO journal 214 11432837
1995 Negative regulation of T-cell adhesion and activation by CD43. Nature 177 7566153
1992 CD43 interferes with T-lymphocyte adhesion. Proceedings of the National Academy of Sciences of the United States of America 161 1594606
1991 Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome. Nature 131 2023632
1995 CD43 is a murine T cell costimulatory receptor that functions independently of CD28. The Journal of experimental medicine 121 7790813
1994 CD43 (S7) expression identifies peripheral B cell subsets. Journal of immunology (Baltimore, Md. : 1950) 113 7989752
2001 Cutting edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1). Journal of immunology (Baltimore, Md. : 1950) 112 11238599
2014 Aberrant glycosylation as biomarker for cancer: focus on CD43. BioMed research international 107 24689054
1999 Frequency of CD43 expression in non-Hodgkin lymphoma. A survey of 742 cases and further characterization of rare CD43+ follicular lymphomas. American journal of clinical pathology 107 10191768
1998 TCR signaling induces selective exclusion of CD43 from the T cell-antigen-presenting cell contact site. Journal of immunology (Baltimore, Md. : 1950) 103 9862667
2006 Galectin-1 binds different CD43 glycoforms to cluster CD43 and regulate T cell death. Journal of immunology (Baltimore, Md. : 1950) 98 17015718
2005 CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution. Immunity 95 15664158
1989 Mechanism of mononuclear cell activation by an anti-CD43 (sialophorin) agonistic antibody. Journal of immunology (Baltimore, Md. : 1950) 95 2542404
2005 CD43 functions as a ligand for E-Selectin on activated T cells. Journal of immunology (Baltimore, Md. : 1950) 92 16339541
2003 Translational control of maternal glp-1 mRNA by POS-1 and its interacting protein SPN-4 in Caenorhabditis elegans. Development (Cambridge, England) 87 12702662
2012 T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival. Annals of the New York Academy of Sciences 85 22288421
2002 Dynamic regulation of T cell immunity by CD43. Journal of immunology (Baltimore, Md. : 1950) 79 12055210
2003 The Drosophila spn-D gene encodes a RAD51C-like protein that is required exclusively during meiosis. Genetics 71 14504227
2009 Roles of rel(Spn) in stringent response, global regulation and virulence of serotype 2 Streptococcus pneumoniae D39. Molecular microbiology 68 19426208
2009 Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and protein kinase C signaling. The Journal of biological chemistry 67 19635795
2019 Human Mesenchymal Stem Cell-Treated Regulatory CD23+CD43+ B Cells Alleviate Intestinal Inflammation. Theranostics 66 31367246
2013 Solid-pseudopapillary neoplasm (SPN) of the pancreas: case series and literature review on an enigmatic entity. International journal of clinical and experimental pathology 65 23696922
1990 Protein sequence and gene structure for mouse leukosialin (CD43), a T lymphocyte mucin without introns in the coding sequence. European journal of immunology 65 2347365
1989 Molecule detected in formalin fixed tissue by antibodies MT1, DF-T1, and L60 (Leu-22) corresponds to CD43 antigen. Journal of clinical pathology 65 2794085
1986 Purification and chemical composition of gpL115, the human lymphocyte surface sialoglycoprotein that is defective in Wiskott-Aldrich syndrome. The Journal of biological chemistry 65 3711098
1999 A common signaling pathway via Syk and Lyn tyrosine kinases generated from capping of the sialomucins CD34 and CD43 in immature hematopoietic cells. Blood 64 10339479
1998 The functional paradox of CD43 in leukocyte recruitment: a study using CD43-deficient mice. The Journal of experimental medicine 64 9841931
1999 CD43, a molecule with multiple functions. Immunologic research 63 10580634
1994 Expression of CD43 on murine and human pluripotent hematopoietic stem cells. Journal of immunology (Baltimore, Md. : 1950) 62 7525720
1994 Altered glycosylation of leukosialin, CD43, in HIV-1-infected cells of the CEM line. The Journal of experimental medicine 61 7964449
1997 Anti-CD43 inhibition of T cell homing. The Journal of experimental medicine 60 9126930
1996 CD43-specific activation of T cells induces association of CD43 to Fyn kinase. The Journal of biological chemistry 56 8910342
2007 CD43 collaborates with P-selectin glycoprotein ligand-1 to mediate E-selectin-dependent T cell migration into inflamed skin. Journal of immunology (Baltimore, Md. : 1950) 54 17277158
1996 Characterization of a CD43/leukosialin-mediated pathway for inducing apoptosis in human T-lymphoblastoid cells. The Journal of biological chemistry 48 8910360
1995 Expression of the leukocyte-associated sialoglycoprotein CD43 by a colon carcinoma cell line. The Journal of biological chemistry 47 7775421
2001 The maternal gene spn-4 encodes a predicted RRM protein required for mitotic spindle orientation and cell fate patterning in early C. elegans embryos. Development (Cambridge, England) 46 11684665
2002 hnRNP-K and Pur(alpha) act together to repress the transcriptional activity of the CD43 gene promoter. Blood 45 12411317
1994 Expression of L-selectin, CD43, and CD44 in synovial fluid neutrophils from patients with inflammatory joint diseases. Evidence for a soluble form of L-selectin in synovial fluid. Arthritis and rheumatism 45 7510491
1988 Induction of CD43 expression during activation and terminal differentiation of human B cells. Scandinavian journal of immunology 45 3264083
1998 T cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activation. The Journal of biological chemistry 43 9603925
1990 Sialophorin (CD43) and the Wiskott-Aldrich syndrome. Immunodeficiency reviews 43 2223062
2000 CD43-mediated signals induce DNA binding activity of AP-1, NF-AT, and NFkappa B transcription factors in human T lymphocytes. The Journal of biological chemistry 42 10908570
2002 Polar redistribution of the sialoglycoprotein CD43: implications for T cell function. Journal of immunology (Baltimore, Md. : 1950) 40 11937524
1997 Anti-CD43 inhibits monocyte-endothelial adhesion in inflammation and atherogenesis. Blood 40 9345042
2023 CD11b + CD43 hi Ly6C lo splenocyte-derived macrophages exacerbate liver fibrosis via spleen-liver axis. Hepatology (Baltimore, Md.) 39 36098707
2003 Changing the DNA landscape: putting a SPN on chromatin. Current topics in microbiology and immunology 38 12596908
1999 High level expression of CD43 inhibits T cell receptor/CD3-mediated apoptosis. The Journal of experimental medicine 38 10601365
2004 CD43 regulation of T cell activation is not through steric inhibition of T cell-APC interactions but through an intracellular mechanism. The Journal of experimental medicine 37 15117976
1999 Cross-linking of membrane CD43 mediates dendritic cell maturation. Journal of immunology (Baltimore, Md. : 1950) 37 10352244
1992 The utility of CD20 and CD43 in subclassification of low-grade B-cell lymphoma on paraffin sections. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 37 1285443
2004 Tumour-expressed CD43 (sialophorin) mediates tumourmesothelial cell adhesion. Biological chemistry 36 15449712
2017 Expression of CD43 in chronic lymphoproliferative leukemias. Cytometry. Part B, Clinical cytometry 35 28073173
1997 Leukosialin (CD43, sialophorin) redistribution in uropods of polarized neutrophils is induced by CD43 cross-linking by antibodies, by colchicine or by chemotactic peptides. Journal of cell science 35 9224764
2013 Cancer-associated CD43 glycoforms as target of immunotherapy. Molecular cancer therapeutics 33 24356816
2006 spn-F encodes a novel protein that affects oocyte patterning and bristle morphology in Drosophila. Development (Cambridge, England) 33 16540510
2004 Early membrane events in polymorphonuclear cell (PMN) apoptosis: membrane blebbing and vesicle release, CD43 and CD16 down-regulation and phosphatidylserine externalization. Biochemical Society transactions 33 15157165
1998 Acquisition of CD24 expression by Lin-CD43+B220(low)ckit(hi) cells coincides with commitment to the B cell lineage. European journal of immunology 33 9842928
1997 Modification of CD43 and other lymphocyte O-glycoproteins by core 2 N-acetylglucosaminyltransferase. Glycobiology 33 9061371
2020 Virion-incorporated PSGL-1 and CD43 inhibit both cell-free infection and transinfection of HIV-1 by preventing virus-cell binding. Proceedings of the National Academy of Sciences of the United States of America 32 32193343
1991 Expression of CD40 and CD43 during activation of human B lymphocytes. Scandinavian journal of immunology 31 1708162
2014 Basic motifs target PSGL-1, CD43, and CD44 to plasma membrane sites where HIV-1 assembles. Journal of virology 29 25320329
2007 Signaling through CD43 regulates CD4 T-cell trafficking. Blood 29 17638845
2003 CD43 modulates severity and onset of experimental autoimmune encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950) 29 14662853
2001 Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules. The Journal of biological chemistry 29 11773067
2018 Mouse and human HSPC immobilization in liquid culture by CD43- or CD44-antibody coating. Blood 28 29453290
2003 Regulation of CD43-induced U937 homotypic aggregation. Experimental cell research 28 14516796
2002 The leukocyte antigen CD43 is expressed in different cell lines of nonhematopoietic origin. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 28 12499775
2015 CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo. Journal of immunology (Baltimore, Md. : 1950) 27 26700769
1998 Regulation of in vitro and in vivo T cell activation by CD43. International immunology 27 9645617
1992 CD43 expression in B cell lymphoma. Journal of clinical pathology 27 1280654
2019 Acute Myeloid and Lymphoblastic Leukemia Cell Interactions with Endothelial Selectins: Critical Role of PSGL-1, CD44 and CD43. Cancers 26 31461905
1989 Persistent superphosphorylation of leukosialin (CD43) in activated T cells and in tumour cell lines. Scandinavian journal of immunology 26 2531463
2012 CD43 in the nucleus and cytoplasm of lung cancer is a potential therapeutic target. International journal of cancer 25 23015282
2019 Differential Expression of CD43, CD81, and CD200 in Classic Versus Variant Hairy Cell Leukemia. Cytometry. Part B, Clinical cytometry 24 31077558
2001 Absence of CD43 fails to alter T cell development and responsiveness. Journal of immunology (Baltimore, Md. : 1950) 24 11123300
2011 CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation. Molecular biology of the cell 23 21289089
2003 Cell surface CD43 determination improves diagnostic precision in late B-cell diseases. British journal of haematology 23 12580968
2003 T cell aggregation induced through CD43: intracellular signals and inhibition by the immunomodulatory drug leflunomide. Journal of leukocyte biology 23 12972508
2017 Discovery of N-(6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5-[(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. Journal of medicinal chemistry 22 29072452
2006 TCR-dependent cell response is modulated by the timing of CD43 engagement. Journal of immunology (Baltimore, Md. : 1950) 22 16751378
2005 Corticotropin-releasing factor (CRF) expression in postnatal and adult rat sacral parasympathetic nucleus (SPN). Cell and tissue research 22 16001267
1999 Drosophila oogenesis: versatile spn doctors. Current biology : CB 22 10021357
2017 The importance of CD39, CD43, CD81, and CD95 expression for differentiating B cell lymphoma by flow cytometry. Cytometry. Part B, Clinical cytometry 21 28509416
2017 The Role of CD200 and CD43 Expression in Differential Diagnosis between Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma. Turkish journal of haematology : official journal of Turkish Society of Haematology 21 28713070
2004 Comparative analysis of T-cell costimulation and CD43 activation reveals novel signaling pathways and target genes. Blood 21 15280197
2021 Mesenchymal Stromal Cells Rapidly Suppress TCR Signaling-Mediated Cytokine Transcription in Activated T Cells Through the ICAM-1/CD43 Interaction. Frontiers in immunology 20 33692786
2020 Determination of CD43 and CD200 surface expression improves accuracy of B-cell lymphoma immunophenotyping. Cytometry. Part B, Clinical cytometry 20 32716606
2017 Emergence of CD43-Expressing Hematopoietic Progenitors from Human Induced Pluripotent Stem Cells. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie 20 28626365
2009 CD43 processing and nuclear translocation of CD43 cytoplasmic tail are required for cell homeostasis. Blood 20 19696198
2003 The CD43 coreceptor molecule recruits the zeta-chain as part of its signaling pathway. Journal of immunology (Baltimore, Md. : 1950) 20 12902492
1999 Signaling through CD43 induces natural killer cell activation, chemokine release, and PYK-2 activation. Blood 20 10515880
1996 Disregulated expression of CD43 (leukosialin, sialophorin) in the B cell lineage leads to immunodeficiency. Journal of immunology (Baltimore, Md. : 1950) 20 8943391
1994 Differential expression of CD43 (leukosialin, sialophorin) by mononuclear phagocyte populations. Journal of leukocyte biology 20 8145025
2011 M-ficolin and leukosialin (CD43): new partners in neutrophil adhesion. Journal of leukocyte biology 19 22167719
2008 CD43, but not P-selectin glycoprotein ligand-1, functions as an E-selectin counter-receptor in human pre-B-cell leukemia NALL-1. Cancer research 19 18245480
1995 CD43 diminishes susceptibility to T lymphocyte-mediated cytolysis. Journal of immunology (Baltimore, Md. : 1950) 19 7822786
2024 Solid pseudopapillary neoplasm (SPN) of the pancreas: current understanding on its malignant potential and management. Discover oncology 18 38498246
2008 CD43 regulates Th2 differentiation and inflammation. Journal of immunology (Baltimore, Md. : 1950) 18 18490738

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