Affinage

SELE

E-selectin · UniProt P16581

Length
610 aa
Mass
66.7 kDa
Annotated
2026-06-10
100 papers in source corpus 31 papers cited in narrative 25 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

E-selectin (SELE/ELAM-1/CD62E) is a cytokine-inducible endothelial transmembrane lectin that initiates leukocyte recruitment to inflamed tissue by capturing circulating cells through carbohydrate recognition (PMID:1701274, PMID:1701275, PMID:1726710, PMID:1713515, PMID:2570036). Its adhesive function rests on binding the sialylated, fucosylated terminal glycans sialyl-Lewis X and sialyl-Lewis a, which share a common spatial arrangement of neuraminic acid and fucose (PMID:1701274, PMID:1701275, PMID:1714447); biosynthesis of these ligands depends on α(1,3)-fucosyltransferase activity, whose transfection alone is sufficient to confer E-selectin-dependent adhesion on non-myeloid cells (PMID:1699667, PMID:1702034). These glycans are displayed on neutrophil and monocyte glycolipids and O-linked glycoproteins — including L-selectin (LECAM-1) concentrated on PMN microvilli, which functions as a counterreceptor — and on the CD15/sialyl-Lewis X structures of cancer cells (PMID:1716182, PMID:1713515, PMID:1721027, PMID:26472821, PMID:28698503). E-selectin mediates the initial tethering/rolling step of adhesion but is CD18/CD11-independent and, on its own, does not trigger inside-out integrin activation or transendothelial migration (PMID:1726710, PMID:1713515, PMID:2570036, PMID:9218615). Through this mechanism it selectively recruits memory (CD45RO+) CD4+ T cells in an activation-independent manner and is required for accumulation of effector CD4+ T cells at inflammatory sites in vivo (PMID:1705666, PMID:1705667, PMID:12629067). Surface expression is transient and inducible by TNF, IL-1, and LPS, driven transcriptionally through NF-κB binding to a defined promoter element (PMID:1713680, PMID:1710341, PMID:1697876); this induction can be modulated by IFN-γ, by NF-κB-targeting agents such as dimethylfumarate, and by inflammatory inputs in non-vascular contexts including the trabecular meshwork (PMID:1697876, PMID:11886496, PMID:20861478). Beyond classical inflammation, E-selectin is engaged by ITGA11 on cancer-associated fibroblasts to activate SRC–VEGFR3–MAPK signalling on lymphatic endothelium, promoting lymphangiogenesis and metastatic spread (PMID:38428409).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1990 High

    Established the molecular ligand of E-selectin, defining how an endothelial lectin recognizes circulating leukocytes at the carbohydrate level.

    Evidence Cell adhesion assays with ELAM-1-expressing cells and purified/synthetic sialyl-Lewis X plus anti-sialyl-Lex inhibition

    PMID:1701274 PMID:1701275

    Open questions at the time
    • Did not identify the protein/lipid scaffolds presenting the glycan in vivo
    • Affinity/avidity contributions under flow not addressed
  2. 1990 High

    Showed that ligand biosynthesis, not the lectin alone, is rate-limiting — α(1,3)-fucosyltransferase activity controls whether a cell can adhere to E-selectin.

    Evidence Transfection of fucosyltransferase cDNA into non-myeloid cells with adhesion assays and flow cytometry for sialyl-Lex

    PMID:1699667 PMID:1702034

    Open questions at the time
    • Which endogenous fucosyltransferases operate in physiological leukocytes not resolved here
    • Did not map the specific glycoprotein/glycolipid carriers
  3. 1991 High

    Broadened ligand specificity to sialyl-Lewis a and explained recognition by a shared glycan conformation, unifying the structural basis of E-selectin binding.

    Evidence Binding assays with immobilized synthetic glycoconjugates on ELAM-1 transfectants plus HSEA conformational modelling

    PMID:1714447

    Open questions at the time
    • No co-crystal structure of lectin domain with ligand
    • Relative in vivo contribution of sLea vs sLex unknown
  4. 1991 High

    Identified L-selectin (LECAM-1) on PMN microvilli as a physiological glycoprotein counterreceptor presenting sialyl-Lewis X to E-selectin.

    Evidence Anti-LECAM-1 blocking, selective surface depletion, and microvillar localization on PMNs binding ELAM-1 transfectants

    PMID:1713515 PMID:1716182

    Open questions at the time
    • Other carrier glycoproteins on PMNs not enumerated
    • Stoichiometry of LECAM-1 glycosylation not defined
  5. 1991 High

    Distinguished E-selectin's adhesive step from integrin function, showing it mediates initial tethering independent of CD18 and not transmigration.

    Evidence Anti-ELAM-1/anti-CD18 blocking, LAD CD18-deficient neutrophils, temperature-dependent and transmigration assays

    PMID:1713515 PMID:1726710 PMID:2570036

    Open questions at the time
    • Did not address signalling consequences of tethering
    • Hand-off to integrin-dependent firm adhesion not mechanistically detailed
  6. 1991 High

    Defined the leukocyte subset selectivity of E-selectin — memory CD4+ T cells adhere in an activation-independent manner distinct from integrin pathways.

    Evidence Adhesion assays to purified E-selectin and transfected COS cells with T-cell subset comparison and antibody blocking

    PMID:1705666 PMID:1705667

    Open questions at the time
    • Glycan determinant distinguishing memory vs naive T cells not identified
    • In vivo relevance addressed only later
  7. 1991 High

    Localized the transcriptional control of E-selectin induction to NF-κB and a defined upstream promoter region, explaining cytokine inducibility.

    Evidence Nuclear run-off, EMSA, PKC inhibitor dissection, and promoter deletion-reporter mapping in endothelial cells

    PMID:1710341 PMID:1713680

    Open questions at the time
    • Identity of the second cis-element factor (−233/−117) not established
    • Upstream kinase cascade to NF-κB not fully defined
  8. 1992 High

    Revealed post-transcriptional and labile-repressor control layers on E-selectin, explaining the transient kinetics of its expression.

    Evidence Nuclear run-on, mRNA half-life Northern analysis, EMSA, and protein-synthesis-inhibitor superinduction with NF-κB site mutants

    PMID:1382069

    Open questions at the time
    • Identity of the labile repressor protein(s) unknown
    • mRNA-destabilizing element not mapped
  9. 1992 Medium

    Defined the receptor input for TNF-driven induction, attributing E-selectin upregulation to the 55 kDa TNF receptor.

    Evidence 125I-TNF cross-linking, receptor-specific mAb identification, and N-terminal TNF peptide antagonism on HUVECs

    PMID:1381227

    Open questions at the time
    • Downstream signalling from p55 to NF-κB not traced
    • Single lab, single cell type
  10. 1997 High

    Clarified that E-selectin tethering is non-signalling — it does not activate Mac-1 or shed L-selectin, placing it strictly upstream of inside-out integrin activation.

    Evidence Flow cytometry for CD11b/CD18 activation epitopes and L-selectin on PMNs bound to E-selectin transfectants/HUVECs with confocal confirmation

    PMID:9218615

    Open questions at the time
    • Co-stimulus required for inside-out signalling not defined
    • Outside-in signalling into endothelium not examined here
  11. 2003 High

    Provided in vivo proof that E-selectin is required for effector CD4+ T-cell accumulation at antigen sites, validating its physiological recruitment role.

    Evidence Antigen-specific T-cell tracking in CD62E-deficient vs wild-type mice with whole-body imaging and BrdU assays

    PMID:12629067

    Open questions at the time
    • Glycan ligand on effector T cells not molecularly defined
    • Redundancy with P-selectin only partially addressed
  12. 2001 Medium

    Expanded the expression repertoire of E-selectin beyond endothelium, showing reverse signalling through membrane TNF-α induces it on activated T cells.

    Evidence Membrane TNF-α cross-linking, protease-resistant mutant transfection, and CD62E mRNA/flow analysis in T cells

    PMID:11123285

    Open questions at the time
    • Functional role of T-cell-expressed E-selectin unclear
    • Signalling pathway from membrane TNF-α not detailed
  13. 2008 Medium

    Linked E-selectin induction to tumor-vascular crosstalk, showing VEGF/VEGF-R2/NF-κB-driven CD62E mediates progenitor cell homing to gliomas.

    Evidence Brain endothelial induction assays, NF-κB promoter-reporter, in vivo neutralizing antibody in orthotopic glioma, and transmigration assays

    PMID:18689869

    Open questions at the time
    • Glycan ligand on homing progenitors not identified
    • Single lab
  14. 2015 Medium

    Connected E-selectin to cancer cell extravasation, identifying CD15/sialyl-Lewis X as the partner mediating tumor adhesion to brain endothelium under flow.

    Evidence Adhesion assays under physiological shear with CD15-blocking mAb and brain metastasis tissue validation

    PMID:26472821 PMID:28698503

    Open questions at the time
    • Contribution to actual transmigration/metastasis in vivo not fully established
    • Other tumor glycan ligands not excluded
  15. 2024 Medium

    Identified a non-leukocyte ligand and signalling axis, showing ITGA11 on CAFs engages E-selectin to drive SRC–VEGFR3–MAPK lymphangiogenic signalling and metastasis.

    Evidence scRNA-seq, spatial transcriptomics, CAF-specific knockout mouse, pathway dissection, and a multicenter clinical cohort

    PMID:38428409

    Open questions at the time
    • Direct ITGA11–SELE binding interface not structurally defined
    • Whether glycan-dependent or protein-protein contact unresolved

Open questions

Synthesis pass · forward-looking unresolved questions
  • How E-selectin tethering integrates with subsequent integrin-dependent firm adhesion, and the structural basis for its ligand and ITGA11 engagement, remain unresolved.
  • No co-crystal structure of the lectin domain with sLex/sLea in the corpus
  • Mechanism of the hand-off to inside-out integrin activation undefined
  • Glycan vs protein basis of the ITGA11–SELE interaction unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098631 cell adhesion mediator activity 6 GO:0008092 cytoskeletal protein binding 3
Localization
GO:0005886 plasma membrane 2
Pathway
R-HSA-168256 Immune System 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-162582 Signal Transduction 1
Partners
FUT9ITGA11SELLTNFRSF1A

Evidence

Reading pass · 25 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1990 ELAM-1 (E-selectin/SELE) mediates leukocyte adhesion through recognition of the carbohydrate ligand sialyl-Lewis X (NeuAc α2,3Gal β1,4(Fuc α1,3)-GlcNAc-), a terminal structure found on neutrophil glycoproteins and glycolipids. Cell adhesion assays using ELAM-1-expressing cells and purified/synthetic carbohydrate structures; inhibition with anti-sialyl-Lex antibodies Science High 1701274 1701275
1991 ELAM-1 also recognizes sialyl-Lewis a (NeuAc α2-3Gal β1-3(Fuc α1-4)GlcNAc), binding it as well as or slightly better than sialyl-Lewis X; HSEA modelling showed both share a common spatial arrangement of neuraminic acid and fucose on one face of the molecule. Cell binding assay with immobilized synthetic glycoconjugates using ELAM-1 cDNA transfectants; hard sphere exo-anomeric (HSEA) conformational calculations The Journal of biological chemistry High 1714447
1990 Transfection of a human α(1,3)-fucosyltransferase cDNA (ELFT) into non-myeloid cells confers ELAM-1-dependent endothelial adhesion, correlating with de novo cell-surface expression of sialyl Lewis X, demonstrating that α(1,3)-fucosyltransferase activity controls biosynthesis of the ELAM-1 ligand. Transfection of fucosyltransferase cDNA into non-myeloid cell lines; cell adhesion assays; flow cytometry for sialyl-Lex expression Cell High 1699667 1702034
1991 Neutrophil LECAM-1 (L-selectin) carries sialyl Lewis X on its surface and presents it to ELAM-1 on endothelium; LECAM-1 is concentrated on PMN microvilli and mediates up to 70% of PMN binding to ELAM-1 transfectants, acting as a counterreceptor/ligand for ELAM-1. Anti-LECAM-1 mAb inhibition assays; selective removal of LECAM-1 from PMN surface; binding assays to ELAM-1 transfected cells; confocal/immunofluorescence localization of LECAM-1 to microvilli Cell High 1713515 1716182
1991 ELAM-1 exclusively mediates adhesion of memory (CD45RO+) T cells, not naive T cells, to activated endothelium; this adhesion is activation-independent (not enhanced by acute T-cell activation), unlike LFA-1- or VLA-4-mediated adhesion. Adhesion assays to purified ELAM-1 protein and ELAM-1-transfected COS cells; antibody blocking; T-cell subset comparisons Nature High 1705666 1705667
1991 ELAM-1 gene transcription is activated by TNF, IL-1, and LPS through PKC-independent activation of NF-κB-like proteins; PKC activity is required for full transcriptional activation but is not sufficient, indicating a dual signalling requirement. Nuclear run-off transcription assays; gel mobility shift assays (EMSA) for NF-κB binding; protein kinase C inhibitor (H7) treatment; 5′ promoter sequence analysis Proceedings of the National Academy of Sciences of the United States of America High 1713680
1991 Cytokine induction of ELAM-1 gene transcription requires two cis-acting elements within 233 bp upstream of the transcription start site: an NF-κB consensus binding site (−94 to −85) and a second element between −233 and −117; NF-κB binding activity is increased in IL-1-induced endothelial cells. ELAM-1 promoter deletion mutants linked to reporter genes transfected into endothelial and non-endothelial cells; gel shift (EMSA) assays Nucleic acids research High 1710341
1992 Labile (short-lived) proteins negatively regulate ELAM-1 gene expression at two levels: (1) mRNA stability and (2) NF-κB-driven transcription initiation; protein synthesis inhibitors (cycloheximide, anisomycin, emetine) superinduce ELAM-1 mRNA and potentiate IL-1β-driven transcription and NF-κB binding; the NF-κB binding site is necessary and sufficient for cycloheximide-mediated superinduction. Nuclear run-on transcription; Northern blot mRNA half-life analysis; EMSA for NF-κB binding; protein synthesis inhibitor treatment; reporter assays with NF-κB site mutants The Journal of biological chemistry High 1382069
1991 ELAM-1-dependent adhesion of HL60 cells does not require N-linked complex oligosaccharides; inhibitors of N-linked glycan processing do not affect adhesion, indicating the ELAM-1 ligand on these cells is likely a glycolipid or O-linked glycoprotein. Adhesion assays to ELAM-1-expressing HUVEC in presence of N-linked glycosylation inhibitors (N-methyl-deoxynojirimycin, 1-deoxymannojirimycin, swainsonine) European journal of immunology Medium 1721027
1991 ELAM-1-dependent neutrophil adhesion to activated endothelium occurs via a CD18/CD11-independent mechanism; ELAM-1 mediates the initial tethering step but does not contribute to transendothelial migration, which is entirely CD18-dependent. Antibody blocking assays with anti-ELAM-1 and anti-CD18 mAbs; LAD-patient neutrophils (CD18-deficient); 37°C vs 4°C adhesion assays; transendothelial migration assay Blood High 1713515 1726710 2570036
1990 ELAM-1 protein expression on endothelial cells is transiently induced by TNF-α, IL-1, or LPS with peak expression at 4–6 hours and disappearance by 24 hours; IFN-γ enhances and prolongs this expression but does not induce it independently, and abrogates the refractory period for restimulation. Flow cytometry of HUVEC surface protein expression; cytokine stimulation time course; blocking experiments with IFN-γ Journal of immunology Medium 1697876
1991 ELAM-1 mediates monocyte adhesion to activated endothelium through a specific counter-structure on monocytes; this is demonstrable at 4°C or with fixed monocytes (reducing active CD18-mediated processes), and is confirmed using ELAM-1-transfected COS cells. Adhesion assays at 37°C and 4°C; fixed monocyte adhesion; ELAM-1-transfected COS cell adhesion; F(ab')2 blocking with anti-ELAM-1 mAb ENA2 Scandinavian journal of immunology Medium 1371364
1992 Rabbit ELAM-1 shares 74% amino acid identity with human ELAM-1 and retains the characteristic selectin domain organization (lectin domain, EGF domain, complement regulatory repeats, transmembrane, cytoplasmic tail), but contains 5 rather than 6 complement regulatory elements; individual extracellular domains are encoded by distinct exons consistent with exon-shuffling evolution of selectins. cDNA cloning, nucleotide and amino acid sequence analysis; genomic restriction mapping; COS cell transfection adhesion assays with rabbit and human PMNs; cross-reactive antibody binding DNA and cell biology Medium 1372169
1992 TNF-α induction of ELAM-1 on HUVECs is mediated via the well-characterized 55 kDa TNF receptor; the N-terminal region of the TNF molecule is not required for this interaction, and a 125I-TNF cross-linking complex characteristic of the 55 kDa receptor is identified on HUVECs. Antibody epitope-mapping inhibition of TNF signalling; 125I-TNF cross-linking; receptor-specific mAb identification; N-terminal TNF peptide antagonism assays Cytokine Medium 1381227
1997 Binding of PMNs to E-selectin (CD62E) alone does not activate CD11b/CD18 (Mac-1) or cause L-selectin shedding; E-selectin tethers PMNs but does not trigger inside-out signalling that would strengthen adhesion. Flow cytometry for CD11b/CD18, activation epitope (CBRM1/5), and L-selectin on PMNs adhered to E-selectin-transfected CHO cells or IL-1β-activated HUVECs; CD62E-blocking mAb; confocal microscopy in situ staining Journal of immunology High 9218615
1994 E-selectin (CD62E) expression on endothelial cells is localized to specific segments of post-capillary venules by electron microscopy; immunogold labelling shows gold particles concentrated at the apical plasma membrane and microvillus-like projections, with highest density induced by LPS compared to TNF-α. Immunogold labelling; transmission electron microscopy (TEM); high-resolution scanning electron microscopy (HR-SEM); silver-enhanced colloidal gold at light microscopy level Micron Medium 7520816
2001 Outside-to-inside (reverse) signalling through membrane TNF-α induces E-selectin (CD62E) expression on activated CD4+ T cells and HTLV-I-infected T cell lines; this induction is transcriptionally regulated and requires cell-to-cell contact or cross-linking of membrane TNF-α, establishing that E-selectin can be expressed on non-endothelial cell types. Anti-TNF-α antibody cross-linking of membrane TNF-α; transfection of wild-type and protease-resistant mutant membrane TNF-α; Northern blot and RT-PCR for CD62E mRNA; cell-to-cell contact assays; flow cytometry Journal of immunology Medium 11123285
2001 Dimethylfumarate (DMF) inhibits TNF-induced CD62E (E-selectin) expression in endothelial cells in an NF-κB-dependent but AP-1-independent manner; 60-min DMF preincubation blocks CD62E expression for up to 24 h, whereas its hydrolysis product methylhydrogenfumarate is ineffective. Flow cytometry; CD62E-, NF-κB-, and AP-1-responsive promoter-reporter constructs; kinetic preincubation experiments; in vivo immunohistochemistry of psoriatic skin The Journal of investigative dermatology Medium 11886496
2003 CD62E (E-selectin) on blood vessel endothelium is required for the preferential accumulation of highly divided effector CD4+ T cells at a site of antigen injection; T cells that acquired CD62P-binding capacity migrated to the injection site in a CD62E-dependent manner without proliferating locally. Genetic epistasis: antigen-specific T-cell tracking in CD62E-deficient vs. wild-type recipient mice; whole-body imaging; BrdU proliferation assays; flow cytometry The Journal of experimental medicine High 12629067
2008 Glioma-derived VEGF induces CD62E (E-selectin) expression on brain endothelial cells via VEGF-R2 and NF-κB pathway activation (peaking at 12 h), which then mediates transendothelial migration of haematopoietic progenitor cells (HPC) toward gliomas; neutralising anti-CD62E antibodies reduce HPC homing to orthotopic gliomas in vivo. In vitro induction assays on brain endothelial cells; VEGF-R2/TGF-β neutralisation; NF-κB CD62E promoter-reporter assay; in vivo neutralising antibody treatment in orthotopic glioma model; tissue microarray; transendothelial migration assay Brain Medium 18689869
2011 IL-1α and IL-1β co-induce ELAM-1 expression in trabecular meshwork (TM) and simultaneously lower intraocular pressure (IOP) ~3-fold in porcine anterior eye perfusion; TGF-β2 acts as an IL-1 antagonist, counteracting both IOP reduction and ELAM-1 induction; IL-6 perfusion neither changes IOP nor induces ELAM-1. Porcine anterior eye perfusion culture; PCR and Western blot for ELAM-1; cytokine co-treatment with TGF-β2; IOP measurement Investigative ophthalmology & visual science Medium 20861478
2015 POAG-causing MYOC mutants (Q368X, Y437H) that are intracellularly retained activate the IL-1/NF-κB inflammatory pathway and co-induce SELE expression in trabecular meshwork cells; wild-type MYOC conversely inhibits IL-1/NF-κB activation and SELE induction; pathway activation levels correlate with intracellular retention of MYOC, not POAG-causing potency. Transient transfection and doxycycline-inducible lentiviral stable transduction of MYOC mutants in TM-1 cells; RT-PCR; ELISA for IL-1α; NF-κB luciferase reporter assay; co-expression of endogenous MYOC and SELE in primary TBM cultures Molecular vision Medium 26396484
2024 ITGA11 on PDGFRα+ITGA11+ cancer-associated fibroblasts (CAFs) engages SELE (E-selectin) on lymphatic endothelial cells to activate the SRC–p-VEGFR3–MAPK signalling pathway, thereby promoting lymphangiogenesis and facilitating lymphovascular invasion and lymph node metastasis in early-stage bladder cancer. Single-cell RNA sequencing; spatial transcriptomics; PDGFRα+ITGA11+ CAF-specific deficient mouse model; mechanistic pathway analysis (SRC/VEGFR3/MAPK); multicenter clinical cohort (n=910) Cancer cell Medium 38428409
2015 CD15 (sialyl Lewis X) on non-small cell lung cancer cells is the binding partner for CD62E (E-selectin) on brain endothelial cells; TNF-α-enhanced CD62E expression on brain endothelium increases cancer cell adhesion, and CD15 immunoblocking significantly reduces adhesion under both static and physiological shear stress conditions. Adhesion assays under static and physiological flow (live-cell); CD15-blocking mAb; flow cytometry; Western blotting; immunofluorescence; immunohistochemistry on human brain metastasis tissue Neuro-oncology Medium 26472821 28698503
1996 Mycobacterial heat shock protein 65 (hsp65) induces CD62E (E-selectin), VCAM-1, and ICAM-1 on endothelial cells; CD62E induction is responsible for the increased adhesion of granulocytes (completely blocked by anti-CD62E mAb), while monocyte adhesion to hsp65-stimulated EC is CD18-dependent and CD62E-independent. Adhesion assays with blocking mAbs; flow cytometry for adhesion molecule expression; IL-1/TNF neutralisation; LPS depletion controls Journal of immunology Medium 8683139

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1990 ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex. Science (New York, N.Y.) 1247 1701274
1990 Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells. Science (New York, N.Y.) 870 1701275
1991 ELAM-1 is an adhesion molecule for skin-homing T cells. Nature 829 1705666
1990 ELAM-1--dependent cell adhesion to vascular endothelium determined by a transfected human fucosyltransferase cDNA. Cell 655 1699667
1991 The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140. Cell 566 1716182
1991 CD62 and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x. Proceedings of the National Academy of Sciences of the United States of America 511 1712483
1991 A carbohydrate domain common to both sialyl Le(a) and sialyl Le(X) is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1. The Journal of biological chemistry 436 1714447
1991 Activation-independent binding of human memory T cells to adhesion molecule ELAM-1. Nature 411 1705667
1991 Four molecular pathways of T cell adhesion to endothelial cells: roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions. The Journal of cell biology 400 1710227
1991 Analysis of T cell stimulation by superantigen plus major histocompatibility complex class II molecules or by CD3 monoclonal antibody: costimulation by purified adhesion ligands VCAM-1, ICAM-1, but not ELAM-1. The Journal of experimental medicine 336 1717633
1990 ELFT: a gene that directs the expression of an ELAM-1 ligand. Cell 325 1702034
1991 Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion. The Journal of biological chemistry 283 1716630
1991 Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1) gene transcription. Proceedings of the National Academy of Sciences of the United States of America 273 1713680
1991 The expression of endothelial leukocyte adhesion molecule-1 (ELAM-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in experimental cutaneous inflammation: a comparison of ultraviolet B erythema and delayed hypersensitivity. The Journal of investigative dermatology 238 1708800
1991 An NF kappa B-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription. Nucleic acids research 238 1710341
1993 Reduced synovial membrane macrophage numbers, ELAM-1 expression, and lining layer hyperplasia in psoriatic arthritis as compared with rheumatoid arthritis. Arthritis and rheumatism 237 7686370
1991 Endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in cutaneous inflammation. The British journal of dermatology 219 1706195
1991 Neutrophil and monocyte adherence to and migration across monolayers of cytokine-activated endothelial cells: the contribution of CD18, ELAM-1, and VLA-4. Blood 196 1726710
1993 Expression patterns of leukocyte adhesion ligand molecules on human liver endothelia. Lack of ELAM-1 and CD62 inducibility on sinusoidal endothelia and distinct distribution of VCAM-1, ICAM-1, ICAM-2, and LFA-3. The American journal of pathology 194 8434643
1991 Antibodies against human neutrophil LECAM-1 (LAM-1/Leu-8/DREG-56 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro. Blood 188 1713515
1991 Cloning of a human alpha(1,3)-fucosyltransferase gene that encodes ELFT but does not confer ELAM-1 recognition on Chinese hamster ovary cell transfectants. The Journal of biological chemistry 155 1718983
1997 Co-expression of ICAM-1, VCAM-1, ELAM-1 and Hsp60 in human arterial and venous endothelial cells in response to cytokines and oxidized low-density lipoproteins. Cell stress & chaperones 142 9250400
1993 Distribution of cell adhesion molecules (ICAM-1, VCAM-1, ELAM-1) in renal tissue during allograft rejection. Transplantation 142 7681228
1999 Inhibition of dextran sulphate sodium (DSS)-induced colitis in mice by intracolonically administered antibodies against adhesion molecules (endothelial leucocyte adhesion molecule-1 (ELAM-1) or intercellular adhesion molecule-1 (ICAM-1)). Clinical and experimental immunology 141 10469048
1990 IFN-gamma regulates the expression of the adhesion molecule ELAM-1 and IL-6 production by human endothelial cells in vitro. Journal of immunology (Baltimore, Md. : 1950) 127 1697876
1992 Intercellular adhesion molecule-1 (ICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in the bronchial mucosa of normal and asthmatic subjects. The European respiratory journal 126 1379941
1993 Importance of E-selectin (ELAM-1) and sialyl Lewis(a) in the adhesion of pancreatic carcinoma cells to activated endothelium. International journal of cancer 124 7687590
2024 PDGFRα+ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay. Cancer cell 122 38428409
1993 Serum ELAM-1 is increased in vasculitis, scleroderma, and systemic lupus erythematosus. The Journal of rheumatology 117 7687701
2003 Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site involves CD62E-dependent migration but not local proliferation. The Journal of experimental medicine 112 12629067
1994 Divergent patterns of ELAM-1, ICAM-1, and VCAM-1 expression on cytomegalovirus-infected endothelial cells. Transplantation 109 7528950
1992 Endothelial cell leukocyte adhesion molecule-1 (ELAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression in gingival tissue during health and experimentally-induced gingivitis. Journal of periodontal research 108 1281230
2001 Outside-to-inside signal through the membrane TNF-alpha induces E-selectin (CD62E) expression on activated human CD4+ T cells. Journal of immunology (Baltimore, Md. : 1950) 105 11123285
1991 Gold treatment of rheumatoid arthritis decreases synovial expression of the endothelial leukocyte adhesion receptor ELAM-1. The Journal of rheumatology 98 1722512
2003 Ultrasound activates the TM ELAM-1/IL-1/NF-kappaB response: a potential mechanism for intraocular pressure reduction after phacoemulsification. Investigative ophthalmology & visual science 97 12714632
1990 Cytokine production (IL-1 alpha, IL-1 beta, and TNF alpha) and endothelial cell activation (ELAM-1 and HLA-DR) in reactive lymphadenitis, Hodgkin's disease, and in non-Hodgkin's lymphomas. An immunocytochemical study. The American journal of pathology 95 1700619
1998 Stimulation with thromboxane A2 (TXA2) receptor agonist enhances ICAM-1, VCAM-1 or ELAM-1 expression by human vascular endothelial cells. Clinical and experimental immunology 94 9649216
2009 Increased CD62e(+) endothelial microparticle levels predict poor outcome in pulmonary hypertension patients. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 90 19782291
1993 Nickel chloride and cobalt chloride, two common contact sensitizers, directly induce expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial leukocyte adhesion molecule (ELAM-1) by endothelial cells. The Journal of investigative dermatology 90 7684425
1995 Molecular cloning, expression, chromosomal assignment, and tissue-specific expression of a murine alpha-(1,3)-fucosyltransferase locus corresponding to the human ELAM-1 ligand fucosyl transferase. The Journal of biological chemistry 89 7559635
1992 Increased binding of synovial T lymphocytes from rheumatoid arthritis to endothelial-leukocyte adhesion molecule-1 (ELAM-1) and vascular cell adhesion molecule-1 (VCAM-1). The Journal of clinical investigation 85 1373738
2004 Effect of high glucose concentrations on expression of ELAM-1, VCAM-1 and ICAM-1 in HUVEC with and without cytokine activation. Physiological research 78 14984317
1991 Cytomegalovirus induced PMN adherence in relation to an ELAM-1 antigen present on infected endothelial cell monolayers. Immunology 72 1709139
1998 Over-expression of ICAM-1, VCAM-1 and ELAM-1 might influence tumor progression in colorectal cancer. International journal of cancer 71 9495363
1989 CD11/CD18-independent neutrophil adherence to inducible endothelial-leucocyte adhesion molecules (E-LAM) in vitro. Immunology 69 2570036
1996 Heat shock protein 65 induces CD62e, CD106, and CD54 on cultured human endothelial cells and increases their adhesiveness for monocytes and granulocytes. Journal of immunology (Baltimore, Md. : 1950) 66 8683139
1991 Expression of ICAM-1, VCAM-1 and ELAM-1 in angiofollicular lymph node hyperplasia (Castleman's disease): evidence for dysplasia of follicular dendritic reticulum cells. Histopathology 64 1723957
1993 Implications of de novo ELAM-1 and VCAM-1 expression in human cardiac allograft rejection. Transplantation 62 7681227
2001 Dimethylfumarate inhibits tumor-necrosis-factor-induced CD62E expression in an NF-kappa B-dependent manner. The Journal of investigative dermatology 59 11886496
1999 Up-regulation of intercellular adhesion molecule-1 (ICAM-1), endothelial leucocyte adhesion molecule-1 (ELAM-1) and class II MHC molecules on pulmonary artery endothelial cells by antibodies against U1-ribonucleoprotein. Clinical and experimental immunology 57 10209523
1992 Role of ELAM-1 in adhesion of monocytes to activated human endothelial cells. Scandinavian journal of immunology 55 1371364
1994 Coordinate regulation of Steel factor, its receptor (Kit), and cytoadhesion molecule (ICAM-1 and ELAM-1) mRNA expression in human vascular endothelial cells of differing origins. Experimental hematology 54 7507856
1992 VCAM-1-, ELAM-1-, and ICAM-1-independent adhesion of melanoma cells to cultured human dermal microvascular endothelial cells. The Journal of investigative dermatology 54 1370233
1991 Involvement of the CD11b/CD18 integrin, but not of the endothelial cell adhesion molecules ELAM-1 and ICAM-1 in tumor necrosis factor-alpha-induced neutrophil toxicity. Journal of immunology (Baltimore, Md. : 1950) 53 1719092
1990 A blocking monoclonal antibody to endothelial-leukocyte adhesion molecule-1 (ELAM1). Biochemical and biophysical research communications 53 1697461
1992 Labile proteins play a dual role in the control of endothelial leukocyte adhesion molecule-1 (ELAM-1) gene regulation. The Journal of biological chemistry 52 1382069
1993 Increased plasma levels of soluble ICAM-1 and ELAM-1 (E-selectin) during acute Plasmodium falciparum malaria. Immunology letters 50 7688346
1992 A role for ELAM-1 in the pathogenesis of MOF during septic shock. The Journal of surgical research 48 1383611
1992 Infiltration of both T cells and neutrophils in the skin is accompanied by the expression of endothelial leukocyte adhesion molecule-1 (ELAM-1): an immunohistochemical and ultrastructural study. The Journal of investigative dermatology 45 1373748
1992 Effect of NADPH oxidase inhibition on endothelial cell ELAM-1 mRNA expression. Biochemical and biophysical research communications 44 1375459
1997 Alterations in the expression of ELAM-1, ICAM-1 and VCAM-1 after in vitro infection of endothelial cells with a clinical isolate of human cytomegalovirus. Microbiology and immunology 42 9087954
1996 Rabbit vascular endothelial adhesion molecules: ELAM-1 is most elevated in acute inflammation, whereas VCAM-1 and ICAM-1 predominate in chronic inflammation. Journal of leukocyte biology 38 8975870
1994 Soluble intercellular adhesion molecule-1 (ICAM-1), endothelial leukocyte adhesion molecule-1 (ELAM-1), and tumor necrosis factor receptor (55 kDa TNF-R) in patients with acute Plasmodium falciparum malaria. Clinical immunology and immunopathology 38 7515338
1993 Cultured Kaposi's sarcoma cell lines express factor XIIIa, CD14, and VCAM-1, but not factor VIII or ELAM-1. Archives of dermatology 38 7692824
1994 Serum levels of soluble E-selectin (ELAM-1) in immune-mediated neuropathies. Neurology 35 7516056
2008 Blood serum levels of vascular cell adhesion molecule (sVCAM-1), intercellular adhesion molecule (sICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) in diabetic retinopathy. Clinical and experimental medicine 34 18791689
2015 TNF-α enhancement of CD62E mediates adhesion of non-small cell lung cancer cells to brain endothelium via CD15 in lung-brain metastasis. Neuro-oncology 32 26472821
2015 Glaucomatous MYOC mutations activate the IL-1/NF-κB inflammatory stress response and the glaucoma marker SELE in trabecular meshwork cells. Molecular vision 31 26396484
2011 Association of ATP1B1, RGS5 and SELE polymorphisms with hypertension and blood pressure in African-Americans. Journal of hypertension 29 21881522
1993 Identical expression of ELAM-1, VCAM-1, and ICAM-1 in sarcoidosis and usual interstitial pneumonitis. The Journal of pathology 29 7688418
1993 Expression of the endothelial leukocyte adhesion molecule-1 (ELAM-1) on endothelial cells in experimental gingivitis in humans. Journal of periodontology 28 7685818
1992 Characterization of cDNA and genomic sequences encoding rabbit ELAM-1: conservation of structure and functional interactions with leukocytes. DNA and cell biology 28 1372169
2017 CD15s/CD62E Interaction Mediates the Adhesion of Non-Small Cell Lung Cancer Cells on Brain Endothelial Cells: Implications for Cerebral Metastasis. International journal of molecular sciences 27 28698503
1994 Expression of endothelial leukocyte adhesion molecule-1 (ELAM-1) in chronic inflammatory demyelinating polyneuropathy. Neurology 27 7514772
1992 Tumour necrosis factor induction of ELAM-1 and ICAM-1 on human umbilical vein endothelial cells--analysis of tumour necrosis factor-receptor interactions. Cytokine 27 1381227
1996 Expression of the adhesion molecules ICAM, VCAM, and ELAM in the arteriosclerotic plaque. General & diagnostic pathology 26 8780927
1997 Binding of human peripheral blood polymorphonuclear leukocytes to E-selectin (CD62E) does not promote their activation. Journal of immunology (Baltimore, Md. : 1950) 24 9218615
2011 Cytokine-dependent ELAM-1 induction and concomitant intraocular pressure regulation in porcine anterior eye perfusion culture. Investigative ophthalmology & visual science 22 20861478
2005 Genomic rearrangements on VCAM1, SELE, APEG1and AIF1 loci in atherosclerosis. Journal of cellular and molecular medicine 22 15784173
1993 Reciprocal expression of CD34 and cell adhesion molecule ELAM-1 on vascular endothelium in acute cutaneous graft-versus-host disease. The Journal of pathology 22 7688420
2008 VEGF-dependent induction of CD62E on endothelial cells mediates glioma tropism of adult haematopoietic progenitor cells. Brain : a journal of neurology 21 18689869
2005 Subcutaneous administration of collagen-polyvinylpyrrolidone down regulates IL-1beta, TNF-alpha, TGF-beta1, ELAM-1 and VCAM-1 expression in scleroderma skin lesions. Clinical and experimental dermatology 21 15663512
1995 Antisense gene suppression against human ICAM-1, ELAM-1, and VCAM-1 in cultured human umbilical vein endothelial cells. Shock (Augusta, Ga.) 20 7552771
2004 High-level endothelial E-selectin (CD62E) cell adhesion molecule expression by a lipopolysaccharide-deficient strain of Neisseria meningitidis despite poor activation of NF-kappaB transcription factor. Clinical and experimental immunology 19 14678268
1994 Immunohistochemistry of port-wine stains and normal skin with endothelium-specific antibodies PAL-E, anti-ICAM-1, anti-ELAM-1, and anti-factor VIIIrAg. Archives of dermatology 18 7517655
1991 The ligand recognized by ELAM-1 on HL60 cells is not carried by N-linked oligosaccharides. European journal of immunology 18 1721027
1996 The NF-kappa B inhibitor, tepoxalin, suppresses surface expression of the cell adhesion molecules CD62E, CD11b/CD18 and CD106. Immunology letters 17 9024987
1997 Induction of mRNAs for ICAM-1, VCAM-1, and ELAM-1 in cultured rat cardiac myocytes and myocardium in vivo. Biochemistry and molecular biology international 16 9137829
2024 Synergistic potentiation of the anti-metastatic effect of a Ginseng-Salvia miltiorrhiza herbal pair and its biological ingredients via the suppression of CD62E-dependent neutrophil infiltration and NETformation. Journal of advanced research 15 39481643
1998 ELAM selectin expression in breast carcinomas detected by automated and quantitative immunohistochemical assays. International journal of oncology 14 9538126
1995 1 alpha, 25-Dihydroxyvitamin D3 decreased ICAM-1 and ELAM-1 expressions on pulmonary microvascular endothelial cells and neutrophil motivation. The Journal of steroid biochemistry and molecular biology 14 7532002
1991 LPS and cytokine-induced endothelial cell IL-6 release and ELAM-1 expression; involvement of serum. European cytokine network 14 1721850
1994 Serum Concentration and Chemotactic Activity of E-selectin (CD62E) in Inflammatory Bowel Disease. Mediators of inflammation 11 18472945
2010 Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery. Journal of cardiothoracic and vascular anesthesia 10 20056442
2009 The role of vascular adhesion molecules PECAM-1 (CD 31), VCAM-1 (CD 106), E-selectin (CD62E) and P-selectin (CD62P) in severe porcine pancreatitis. Histology and histopathology 10 19283663
1996 Alterations in ICAM-1 and ELAM-1 expression in psoriatic lesions following various treatments. Journal of dermatological science 10 8902653
1995 Preoperative serum intercellular adhesion molecule-1 (ICAM-1) and E-selectin (endothelial cell leukocyte adhesion molecule, ELAM-1) in patients with epithelial ovarian cancer. Anticancer research 10 8572633
1994 Application of immunogold labelling for light and electron microscopic localization of endothelial leukocyte adhesion molecule 1 (ELAM-1) on cultured human endothelial cells. Micron (Oxford, England : 1993) 10 7520816
2016 Relationship of SELE A561C and G98T Variants With the Susceptibility to CAD. Medicine 9 26937892
2012 Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level. BMC medical genetics 9 23190470

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