Affinage

SELE

E-selectin · UniProt P16581

Round 2 corrected
Length
610 aa
Mass
66.7 kDa
Annotated
2026-04-28
130 papers in source corpus 34 papers cited in narrative 33 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

E-selectin (SELE/ELAM-1/CD62E) is a cytokine-inducible endothelial cell-surface C-type lectin that mediates calcium-dependent adhesion of leukocytes and tumor cells by recognizing sialyl-Lewis X and sialyl-Lewis A carbohydrate determinants displayed on glycoprotein ligands including PSGL-1, CD44, and ESL-1 (PMID:1701274, PMID:1714447, PMID:22021370). Transcription is driven by NF-κB together with a second upstream cis-element in response to TNF, IL-1, and LPS, and is fine-tuned post-transcriptionally by labile-protein-dependent mRNA destabilization and TNF-induced miR-31 negative feedback (PMID:1713680, PMID:1710341, PMID:1382069, PMID:19949084). Upon leukocyte engagement, E-selectin clusters at contact sites and its cytoplasmic domain links to an actin-associated complex containing α-actinin, vinculin, filamin, paxillin, and FAK, while ligand-specific outside-in signaling through PSGL-1 activates FGR/SYK to extend LFA-1 on rolling neutrophils, promoting slow rolling and downstream firm adhesion (PMID:8609175, PMID:20445017). E-selectin directs skin-homing of CLA⁺ memory T cells and effector CD4⁺ T-cell accumulation at antigen sites, and on lymphatic endothelium engages ITGA11 on cancer-associated fibroblasts to activate SRC–p-VEGFR3–MAPK-driven lymphangiogenesis (PMID:1705666, PMID:12629067, PMID:38428409).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1989 High

    The molecular identity of the cytokine-inducible endothelial leukocyte adhesion molecule was unknown; cloning of ELAM-1 revealed a mosaic protein with an N-terminal lectin domain, an EGF domain, and six complement regulatory repeats, and demonstrated that it directly mediates neutrophil adhesion.

    Evidence cDNA cloning by functional expression selection in COS cells with adhesion assay validation

    PMID:2466335

    Open questions at the time
    • Carbohydrate ligand identity unknown
    • Transcriptional regulation mechanism undefined
    • In vivo role not tested
  2. 1990 High

    The nature of the E-selectin ligand was resolved as the tetrasaccharide sialyl-Lewis X (and subsequently sialyl-Lewis A), with α(1,3)-fucosyltransferase expression being necessary and sufficient to generate the ligand on non-myeloid cells, establishing E-selectin as a carbohydrate-binding lectin.

    Evidence Purified carbohydrate inhibition assays, fucosyltransferase cDNA transfection conferring binding in non-binding cells

    PMID:1699667 PMID:1701274 PMID:1701275 PMID:1702034

    Open questions at the time
    • Specific glycoprotein carriers on leukocytes not identified
    • Three-dimensional structure of the lectin domain not determined
    • Relative contribution of glycolipid vs glycoprotein ligands unclear
  3. 1990 High

    The transcriptional mechanism driving cytokine-inducible ELAM-1 expression was shown to require NF-κB activation in a PKC-independent manner, with a second upstream cis-element also necessary, and labile repressor proteins controlling both mRNA stability and NF-κB activity in resting cells.

    Evidence Nuclear run-on assays, gel mobility shift assays, PKC inhibitor studies, promoter deletion reporters, protein synthesis inhibitor superinduction experiments

    PMID:1382069 PMID:1710341 PMID:1713680

    Open questions at the time
    • Identity of the second cis-element transcription factor not determined
    • Nature of the labile repressor protein not identified
    • Post-transcriptional regulation by non-coding RNA not yet explored
  4. 1991 High

    E-selectin was found to selectively bind memory (CD45RO⁺) but not naive T cells, and specifically the CLA⁺ skin-homing subset, with preferential vascular expression at cutaneous inflammatory sites — establishing E-selectin as a tissue-selective vascular addressin for skin immune surveillance.

    Evidence Adhesion assays with purified T-cell subsets, ELAM-1-transfected COS cells, immunohistology of cutaneous vs non-cutaneous tissues

    PMID:1705666 PMID:1705667 PMID:1710227

    Open questions at the time
    • Molecular basis for CLA⁺ T-cell selectivity not defined
    • In vivo requirement not tested in genetic models
    • Ligand identity on memory T cells not determined
  5. 1993 High

    The intracellular fate of E-selectin after surface expression was defined: internalized E-selectin routes exclusively to endosomes and lysosomes for degradation (not recycled), and cytoplasmic domain deletion abolishes internalization, revealing tail-dependent trafficking.

    Evidence Immunofluorescent antibody tracking, subcellular fractionation, cytoplasmic domain deletion mutants in AtT-20 cells

    PMID:7694691

    Open questions at the time
    • Specific cytoplasmic tail sorting motifs not mapped
    • Ubiquitination or other post-translational signals for lysosomal targeting not investigated
  6. 1994 High

    The atomic structure of the E-selectin lectin/EGF domain was solved at 2.0 Å, revealing the Ca²⁺ coordination geometry and specific residues for carbohydrate contact, confirmed by mutagenesis — providing the structural basis for selectin-ligand recognition.

    Evidence X-ray crystallography at 2.0 Å resolution with site-directed mutagenesis and binding assays

    PMID:7509040

    Open questions at the time
    • Co-crystal with sLex/sLea ligand not obtained
    • Structural basis for selectivity among selectin family members not resolved
  7. 1996 High

    E-selectin was shown to couple leukocyte binding to cytoskeletal remodeling: upon engagement it clusters at contact sites and its cytoplasmic domain recruits α-actinin, vinculin, filamin, paxillin, and FAK, while PSGL-1 was identified as an E-selectin ligand whose binding requires core 2 O-glycans but not tyrosine sulfation.

    Evidence Confocal microscopy, cytoskeletal fractionation, magnetic twisting cytometry, tailless mutant; CHO cell reconstitution with glycosyltransferases and tyrosine mutagenesis

    PMID:8609175 PMID:8621728

    Open questions at the time
    • Direct binding partners within the cytoplasmic tail complex not mapped by domain interaction
    • Signaling consequences of cytoskeletal coupling in endothelial cells not defined
  8. 2001 High

    CD44 bearing sialylated, fucosylated N-glycans was identified as an additional E-selectin ligand on hematopoietic progenitor cells, mediating rolling under physiological shear over a wider range than PSGL-1, broadening the repertoire of E-selectin counter-receptors.

    Evidence Shear-based rolling assay on E-selectin-expressing bone marrow endothelium, selectin-Ig fusion protein binding, neutralizing antibodies

    PMID:11402070

    Open questions at the time
    • Relative in vivo contribution of CD44 vs PSGL-1 on HPCs not established genetically
    • Specific N-glycan structures on CD44 mediating binding not characterized
  9. 2003 High

    Genetic knockout of E-selectin in mice demonstrated its in vivo requirement for accumulation of antigen-specific effector CD4⁺ T cells at peripheral antigen injection sites, establishing the physiological non-redundant role of E-selectin in effector T-cell trafficking.

    Evidence Adoptive transfer of antigen-specific CD4 T cells into E-selectin-deficient mice with whole-body tracking

    PMID:12629067

    Open questions at the time
    • Whether P-selectin provides partial compensation in vivo not fully resolved
    • Tissue-specific requirements beyond skin not systematically addressed
  10. 2009 High

    A post-transcriptional negative feedback loop was identified: TNF induces miR-31 which targets the E-selectin 3′ UTR, dampening E-selectin expression and neutrophil adhesion — adding a miRNA layer to the transcriptional regulation already known.

    Evidence miR-31 mimic and antagonist transfection in endothelial cells with neutrophil adhesion functional readout

    PMID:19949084

    Open questions at the time
    • Relative quantitative contribution of miR-31 vs mRNA instability in vivo not determined
    • Whether other miRNAs (miR-17-3p) act cooperatively not fully dissected
  11. 2010 High

    The signaling cascade triggered by E-selectin engagement on rolling neutrophils was dissected: PSGL-1 ligation activates SYK and FGR (Src family kinase), which via PLC and p38 MAPK extend LFA-1 to an intermediate conformation enabling slow rolling — linking selectin-mediated tethering to integrin activation.

    Evidence Flow-based rolling assay on immobilized E-selectin, conformation-specific integrin reporter antibodies, kinase inhibitors, PSGL-1 blocking

    PMID:20445017

    Open questions at the time
    • Whether ESL-1 and CD44 activate distinct downstream kinases not fully mapped in same system
    • Structural basis for PSGL-1 transmembrane signal initiation unclear
  12. 2024 Medium

    An unexpected non-immune role emerged: E-selectin on lymphatic endothelial cells engages ITGA11 on cancer-associated fibroblasts, activating SRC–p-VEGFR3–MAPK to drive lymphangiogenesis and lymph node metastasis in bladder cancer.

    Evidence Single-cell RNA-seq, spatial transcriptomics, ITGA11-deficient mouse model, multicenter clinical cohort

    PMID:38428409

    Open questions at the time
    • Whether E-selectin–ITGA11 interaction is direct or requires carbohydrate ligands not confirmed
    • Generalizability to other tumor types not established
    • Independent replication needed

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key mechanistic questions remain: the identity of the second cis-element transcription factor cooperating with NF-κB, the structural basis of E-selectin–ligand selectivity from co-crystal structures with sLex/sLea, and whether the lymphangiogenesis-promoting role via ITGA11 represents a general E-selectin function beyond bladder cancer.
  • No co-crystal structure with carbohydrate ligand
  • Second transcription factor for promoter induction unidentified
  • E-selectin function in lymphangiogenesis requires independent validation

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098631 cell adhesion mediator activity 6 GO:0008092 cytoskeletal protein binding 1
Localization
GO:0005886 plasma membrane 3 GO:0005576 extracellular region 1 GO:0005764 lysosome 1 GO:0005768 endosome 1
Pathway
R-HSA-168256 Immune System 6 R-HSA-1500931 Cell-Cell communication 5 R-HSA-162582 Signal Transduction 5
Partners
ACTN1CD44FLNAITGA11PTK2PXNSELPLGVCL

Evidence

Reading pass · 33 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1989 ELAM-1 (SELE/E-selectin) was cloned by transient expression in COS cells from a subtracted cDNA library of cytokine-treated endothelial cells. The predicted protein structure contains an amino-terminal lectin-like domain, an EGF domain, and six tandem complement regulatory repeat motifs. Expression is cytokine-inducible, reaching maximum at 2–4 hours and decaying by 24 hours, and transfected cells support adhesion of neutrophils and HL-60 cells in a Ca2+-dependent but temperature-independent manner. cDNA cloning by transient expression/functional adhesion selection, structural domain analysis, transfection adhesion assay Science High 2466335
1990 ELAM-1 (E-selectin) mediates cell adhesion by recognizing the carbohydrate ligand sialyl-Lewis X (NeuAc α2,3Gal β1,4[Fuc α1,3]GlcNAc), a terminal structure on neutrophil glycoproteins and glycolipids, establishing the lectin function of its N-terminal carbohydrate recognition domain. Cell adhesion inhibition assay with purified carbohydrate structures and monoclonal antibodies; COS-cell transfection adhesion assay Science High 1701274 1701275
1990 Transfection of an α(1,3)-fucosyltransferase cDNA into non-myeloid cells confers ELAM-1-dependent endothelial adhesion, with binding activity correlating with de novo cell-surface expression of sialyl-Lewis X. This demonstrated that specific fucosyltransferases regulate ELAM-1 ligand biosynthesis. Fucosyltransferase cDNA transfection, flow cytometry for sLex expression, ELAM-1-dependent adhesion assay Cell High 1699667
1990 ELFT, a cloned α(1,3)-fucosyltransferase specifically expressed in cell types that bind ELAM-1, confers ELAM-1 binding activity when transfected into non-binding cell lines, indicating that a fucosylated carbohydrate structure is an essential component of the ELAM-1 ligand. cDNA cloning, transfection-based adhesion assay, enzymatic activity assay Cell High 1702034
1990 ELAM-1 gene transcription is activated by TNF, IL-1, and LPS via PKC-independent activation of NF-κB-like DNA binding activity in endothelial cells, as demonstrated by nuclear run-on experiments and gel mobility shift assays. PKC blockade inhibits ELAM-1 transcription despite intact NF-κB activation, indicating NF-κB is necessary but not sufficient. Nuclear run-on transcription assay, gel mobility shift assay, PKC inhibitor studies, promoter sequence analysis PNAS High 1710341 1713680
1991 The ELAM-1 promoter contains an NF-κB consensus binding site (−94 to −85) that is necessary but not sufficient for cytokine-induced transcription; a second cis-acting element between −233 and −117 is also required, demonstrating that cytokine induction of ELAM-1 involves combinatorial transcription factor action. Reporter gene deletion mutant constructs, gel shift assay, transient transfection in endothelial and non-endothelial cells Nucleic Acids Research High 1710341
1991 Both sialyl-Lewis A (NeuAc α2-3Gal β1-3[Fuc α1-4]GlcNAc) and sialyl-Lewis X are potent ligands for ELAM-1, recognizing a common carbohydrate domain involving neuraminic acid and fucose. Molecular modeling (HSEA calculations) shows both hexasaccharides adopt similar three-dimensional conformations. Cell binding assay with immobilized synthetic glycoconjugates, ELAM-1 cDNA transfectants, HSEA molecular modeling Journal of Biological Chemistry High 1714447
1991 The ELAM-1 gene spans ~13 kb, contains 14 exons, is present as a single copy on human chromosome 1q12→qter, and has exon-intron boundaries that correlate with functional protein domain subdivisions (lectin domain, EGF domain, six complement regulatory repeats each encoded by distinct exons). The promoter contains NF-κB and AP-1 consensus sites. Genomic cloning, restriction mapping, sequencing, exon-intron boundary determination, human-mouse somatic hybrid cell panel for chromosomal mapping Journal of Biological Chemistry High 1703529
1991 Neutrophil LECAM-1 (L-selectin) bears sialyl-Lewis X modifications and can present this oligosaccharide ligand to ELAM-1 on endothelial cells. LECAM-1 is concentrated on PMN surface microvilli (initial contact sites), and anti-LECAM-1 antibodies or selective LECAM-1 removal inhibit PMN binding to ELAM-1 transfectants by up to 70%, identifying a receptor-counterreceptor interaction between the two selectins. Anti-LECAM-1 antibody blocking, selective LECAM-1 removal, adhesion assays with ELAM-1 transfected cells, flow cytometry, immunoelectron microscopy Cell High 1716182
1991 The sialyl-Lewis X ligand for ELAM-1 on HL-60 cells is not carried by N-linked oligosaccharides (complex-type N-glycans), since inhibitors of N-linked glycoprotein processing (N-methyl-deoxynojirimycin, 1-deoxymannojirimycin, swainsonine) do not affect ELAM-1-dependent adhesion, suggesting the ligand is a glycolipid or O-linked glycoprotein. Glycosylation processing inhibitors (N-methyl-deoxynojirimycin, deoxymannojirimycin, swainsonine), cell adhesion assay with HUVEC European Journal of Immunology Medium 1721027
1991 IFN-γ enhances and prolongs ELAM-1 expression on TNF/IL-1/LPS-activated endothelial cells, abrogates the refractory period for ELAM-1 restimulation, and potentiates IL-6 production, defining a regulatory role for IFN-γ in modulating ELAM-1-dependent inflammatory adhesion. Flow cytometry for cell-surface ELAM-1, cytokine co-stimulation experiments in HUVEC, cytokine pre-treatment timing studies Journal of Immunology Medium 1697876
1991 ELAM-1 exclusively mediates adhesion of memory (CD45RO+) but not naive CD4+ T cells, and this adhesion is independent of acute T-cell activation signals that regulate integrin-mediated adhesion, demonstrating a distinct, activation-independent adhesion pathway for memory T-cell subset trafficking. Adhesion assay to purified ELAM-1, antibody blocking, T-cell subset characterization by flow cytometry Nature High 1705666 1705667 1710227
1991 ELAM-1 mediates adhesion of a skin-homing subset of circulating memory T cells defined by cutaneous lymphocyte-associated antigen (CLA), as shown by ELAM-1-transfected COS cell adhesion assays. Vascular ELAM-1 expression is preferentially found in cutaneous over non-cutaneous inflammatory sites, supporting its role as a skin vascular addressin. ELAM-1-transfected COS cell adhesion assay, T-cell subset flow cytometry, immunohistology of tissue specimens Nature High 1705666
1991 Labile (short-lived) proteins play a dual role in ELAM-1 gene regulation: they destabilize ELAM-1 mRNA and suppress NF-κB binding activity in resting cells. Protein synthesis inhibitors (cycloheximide, anisomycin, emetine) superinduce ELAM-1 mRNA by stabilizing the transcript and potentiating NF-κB binding, with the NF-κB binding site in the promoter being necessary and sufficient for superinduction. Protein synthesis inhibitors, mRNA half-life measurements, nuclear run-on transcription assay, NF-κB gel shift assay, promoter deletion reporter assays Journal of Biological Chemistry High 1382069
1991 ELAM-1 binds monocytes through a counter-structure on monocytes; at reduced metabolic activity (4°C or fixed monocytes), anti-ELAM-1 F(ab')2 strongly blocks monocyte adhesion to activated HUVEC following kinetics that parallel ELAM-1 surface expression, and is confirmed using ELAM-1-transfected COS cells. Antibody blocking adhesion assay at 37°C and 4°C, fixed-cell adhesion, COS-cell transfection adhesion assay Scandinavian Journal of Immunology Medium 1371364
1992 Labile proteins play a dual role in controlling ELAM-1 gene expression through both mRNA stability and transcriptional mechanisms; treatment with protein synthesis inhibitors superinduces ELAM-1 via NF-κB-dependent promoter activation and mRNA stabilization. Nuclear run-on assay, mRNA half-life determination, gel shift assay Journal of Biological Chemistry High 1382069
1993 Sialyl-Lewis A (SLea) on pancreatic carcinoma cells mediates adhesion to E-selectin on cytokine-activated endothelial cells; anti-E-selectin and anti-SLea antibodies block augmented attachment at both 4°C and 25°C, while anti-SLex does not, revealing SLea as the dominant ELAM-1 ligand on these tumor cells. Adhesion assay to IL-1β/TNF-α-activated HUVEC, antibody blocking (anti-E-selectin, anti-SLea, anti-SLex), flow cytometry for E-selectin expression International Journal of Cancer Medium 7687590
1994 The crystal structure of the lectin/EGF domain region of human E-selectin was determined at 2.0 Å resolution, revealing limited interdomain contact, Ca2+ coordination distinct from other C-type lectins, and a specific region/amino acid side chains involved in ligand binding as confirmed by mutagenesis. X-ray crystallography at 2.0 Å, site-directed mutagenesis, functional binding assays Nature High 7509040
1993 After surface expression, internalized E-selectin is routed exclusively to endosomes and lysosomes for degradation, in contrast to P-selectin which recycles to Weibel-Palade body storage granules. Deletion of the cytoplasmic domain abolishes internalization of both selectins, demonstrating cytoplasmic-tail-dependent intracellular trafficking. Immunofluorescent antibody tracking, subcellular fractionation, Western blot, AtT-20 cell transfection with cytoplasmic domain deletion mutants Molecular Biology of the Cell High 7694691
1996 Leukocyte adhesion to cytokine-activated endothelium induces transmembrane linkage of E-selectin to the actin cytoskeleton through its cytoplasmic domain. E-selectin clusters at leukocyte attachment sites, co-purifies with α-actinin, vinculin, filamin, paxillin, and focal adhesion kinase (FAK) but not talin. A tailless (cytoplasmic domain-deleted) E-selectin mutant supports leukocyte attachment but fails to associate with the cytoskeleton or resist mechanical stress. Confocal microscopy, detergent-based cytoskeletal fractionation, Western blot, paramagnetic bead pull-down, magnetic twisting cytometer, COS-7 cell transfection with tailless mutant Journal of Cell Biology High 8609175
1996 PSGL-1 requires core 2 O-linked glycans (sialylated and fucosylated) to bind E-selectin, but unlike P-selectin binding, E-selectin binding by PSGL-1 does not require tyrosine sulfation, as phenylalanine replacement of three consensus tyrosines abolished P-selectin binding but not E-selectin binding. CHO cell co-transfection with PSGL-1, C2GnT, and α1,3-fucosyltransferases; tyrosine-to-phenylalanine mutagenesis; binding assays to selectin-expressing cells Journal of Biological Chemistry High 8621728
2001 CD44, modified with sialylated, fucosylated N-glycans (not O-glycans), functions as an E-selectin ligand on human hematopoietic progenitor cells (HPCs), mediating rolling on E-selectin-expressing bone marrow endothelial cells under physiological flow conditions over a wider shear range than PSGL-1. Shear-based adherence assay, immunopurification of membrane proteins, flow cytometry, neutralizing antibodies, selectin-Ig fusion protein binding assays Journal of Cell Biology High 11402070
2001 Outside-to-inside (reverse) signaling through membrane TNF-α induces E-selectin (CD62E) expression on activated CD4+ T cells and HTLV-I-infected T cell lines (not just endothelial cells), via transcriptional upregulation. Wild-type and cleavage-resistant membrane TNF-α mutant both support CD62E induction by anti-TNF-α antibody, confirming the reverse-signaling mechanism. Anti-TNF-α antibody stimulation of membrane TNF-α-expressing cells, Northern blot, RT-PCR, transfection with WT and mutant membrane TNF-α in Jurkat and HeLa cells, cell-cell contact assay Journal of Immunology Medium 11123285
2003 Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site requires CD62E (E-selectin) expression on blood vessels; the most-divided effector CD4 T cells bind CD62P in draining lymph nodes, then enter the injection site via CD62E recognition, and are retained in a nonproliferative state by peptide-MHC II recognition. Adoptive transfer of antigen-specific CD4 T cells tracked in whole body, CD62E-deficient recipient mice (genetic knockout), antigen injection model Journal of Experimental Medicine High 12629067
2009 TNF-induced miRNAs miR-31 and miR-17-3p provide negative feedback control of E-selectin expression by pairing with target sequences in E-selectin mRNA 3' UTR. Specific antagonism of miR-31 increased neutrophil adhesion to endothelial cells, while miR-31 mimic transfection decreased adhesion, establishing a post-transcriptional regulatory loop. miRNA antagonism and mimic transfection in endothelial cells, neutrophil adhesion assay, 3'-UTR target identification Journal of Immunology High 19949084
2010 Human neutrophil rolling on E-selectin (or P-selectin) induces the extended (KIM127/NKI-L16 epitopes) but not the high-affinity conformation (mAb24 epitope) of LFA-1 (αLβ2), in a PSGL-1-, Src family kinase (FGR)-, and SYK-dependent manner, promoting slow rolling but not firm adhesion. This signaling requires phospholipase C and p38 MAP kinase. Flow-based rolling assay on immobilized E-selectin and P-selectin, reporter antibody binding assay for integrin conformational epitopes, kinase inhibitors, PSGL-1 blocking antibody Blood High 20445017
2011 PSGL-1, CD44, and ESL-1 are physiologic glycoprotein ligands for E-selectin on mature leukocytes mediating tethering and rolling. PSGL-1 and CD44 induce signals that activate β2 integrin LFA-1 and promote slow rolling, whereas ESL-1 induces signals that activate Mac-1 in adherent neutrophils, assigning specialized adhesive and signaling roles to distinct E-selectin ligands. Flow-based adhesion assay, genetic knockout mice, integrin activation assays, signaling pathway analysis (literature synthesis with cited mouse experiments) Blood High 22021370
2001 Dimethylfumarate (DMF) at ≤70 µM specifically inhibits TNF-induced CD62E (E-selectin) but not CD54 (ICAM-1) expression in endothelial cells by inhibiting NF-κB (but not AP-1) promoter activation, as demonstrated using CD62E-, NF-κB-, and AP-1-responsive promoter reporter constructs. A 60-min preincubation is sufficient for 24-h blockade; the hydrolysis product methylhydrogenfumarate is inactive. Flow cytometry, NF-κB/AP-1/CD62E promoter-reporter transfection assays, in vivo skin biopsy immunohistochemistry in psoriasis patients treated with oral fumaric acid esters Journal of Investigative Dermatology Medium 11886496
2010 Indoxyl sulfate (a uremic toxin) enhances E-selectin expression on TNF-α-activated HUVEC via JNK- and NF-κB-dependent pathways (not through ICAM-1 or VCAM-1), and in vivo anti-E-selectin antibody treatment reduces indoxyl sulfate-induced leukocyte adhesion to the femoral artery in nephrectomized mice. Flow cytometry, JNK/NF-κB kinase inhibitors, NAD(P)H oxidase inhibitor, flow-based adhesion assay, anti-E-selectin antibody in CKD mouse model Journal of Biological Chemistry Medium 20937831
2008 E-selectin (CD62E) on tumor blood vessels is down-regulated in squamous cell carcinomas (SCCs), resulting in reduced CLA+ T-cell infiltration. TLR7 agonist imiquimod induces E-selectin on tumor vessels and recruits CLA+CD8+ T cells with evidence of tumor regression, demonstrating that tumor immune evasion involves active suppression of vascular E-selectin. Immunohistochemistry of human SCC biopsies, imiquimod treatment (in vivo and in vitro), flow cytometry, regulatory T-cell functional assays Journal of Experimental Medicine Medium 18794336
2015 SELE (E-selectin/CD62E) expression in trabecular meshwork cells is co-induced with MYOC mutations (Q368X, Y437H) that activate the IL-1/NF-κB inflammatory stress pathway; wild-type MYOC inhibits NF-κB activity and decreases SELE induction, establishing SELE as a downstream marker of the IL-1/NF-κB pathway in trabecular meshwork glaucoma pathology. Lentiviral stable transduction with doxycycline-inducible mutant MYOC constructs, RT-PCR, ELISA for IL-1α protein, NF-κB luciferase reporter assay Molecular Vision Medium 26396484
2024 PDGFRα+ITGA11+ cancer-associated fibroblasts (CAFs) promote lymphangiogenesis by recognizing SELE (E-selectin) on lymphatic endothelial cells via the ITGA11 surface receptor, activating the SRC-p-VEGFR3-MAPK signaling pathway to drive lymphovascular invasion and lymph node metastasis in early-stage bladder cancer. Single-cell RNA sequencing, spatial transcriptomics, CAF-specific ITGA11-deficient mouse model, multicenter clinical cohort (910 cases), signaling pathway analysis Cancer Cell Medium 38428409
1997 After surface induction, E-selectin protein distributes over the entire apical endothelial cell surface including microvillus-like projections (particularly with TNF-α), as demonstrated by immunogold labeling with TEM and HR-SEM. LPS treatment produces the highest density of E-selectin surface labeling without inducing cytotoxicity or ultrastructural changes. Immunogold labeling (silver-enhanced colloidal gold), transmission electron microscopy (TEM), high-resolution scanning electron microscopy (HR-SEM), quantitative gold particle counting Micron Low 7520816

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1989 Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science (New York, N.Y.) 2000 2466335
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
1990 ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex. Science (New York, N.Y.) 1247 1701274
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
1990 Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells. Science (New York, N.Y.) 870 1701275
1991 ELAM-1 is an adhesion molecule for skin-homing T cells. Nature 829 1705666
1999 Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nature genetics 769 10391210
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
1990 ELAM-1--dependent cell adhesion to vascular endothelium determined by a transfected human fucosyltransferase cDNA. Cell 655 1699667
1991 The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140. Cell 566 1716182
1991 CD62 and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x. Proceedings of the National Academy of Sciences of the United States of America 511 1712483
1991 A carbohydrate domain common to both sialyl Le(a) and sialyl Le(X) is recognized by the endothelial cell leukocyte adhesion molecule ELAM-1. The Journal of biological chemistry 436 1714447
1991 Activation-independent binding of human memory T cells to adhesion molecule ELAM-1. Nature 411 1705667
2005 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome research 409 16344560
1991 Four molecular pathways of T cell adhesion to endothelial cells: roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions. The Journal of cell biology 400 1710227
2011 Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow. Blood 361 22021370
1994 Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains. Nature 345 7509040
1991 Analysis of T cell stimulation by superantigen plus major histocompatibility complex class II molecules or by CD3 monoclonal antibody: costimulation by purified adhesion ligands VCAM-1, ICAM-1, but not ELAM-1. The Journal of experimental medicine 336 1717633
1990 ELFT: a gene that directs the expression of an ELAM-1 ligand. Cell 325 1702034
1991 Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion. The Journal of biological chemistry 283 1716630
2009 Cutting edge: TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells: feedback control of inflammation. Journal of immunology (Baltimore, Md. : 1950) 281 19949084
1991 Activation of endothelial-leukocyte adhesion molecule 1 (ELAM-1) gene transcription. Proceedings of the National Academy of Sciences of the United States of America 273 1713680
1996 Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin. The Journal of biological chemistry 264 8621728
2001 CD44 is a major E-selectin ligand on human hematopoietic progenitor cells. The Journal of cell biology 246 11402070
1991 The expression of endothelial leukocyte adhesion molecule-1 (ELAM-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in experimental cutaneous inflammation: a comparison of ultraviolet B erythema and delayed hypersensitivity. The Journal of investigative dermatology 238 1708800
1991 An NF kappa B-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule 1 (ELAM-1) gene transcription. Nucleic acids research 238 1710341
1993 Reduced synovial membrane macrophage numbers, ELAM-1 expression, and lining layer hyperplasia in psoriatic arthritis as compared with rheumatoid arthritis. Arthritis and rheumatism 236 7686370
2022 Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue. Nature communications 220 35013188
1991 Endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in cutaneous inflammation. The British journal of dermatology 219 1706195
1991 Neutrophil and monocyte adherence to and migration across monolayers of cytokine-activated endothelial cells: the contribution of CD18, ELAM-1, and VLA-4. Blood 196 1726710
1993 Expression patterns of leukocyte adhesion ligand molecules on human liver endothelia. Lack of ELAM-1 and CD62 inducibility on sinusoidal endothelia and distinct distribution of VCAM-1, ICAM-1, ICAM-2, and LFA-3. The American journal of pathology 194 8434643
2008 Globotriaosylceramide induces oxidative stress and up-regulates cell adhesion molecule expression in Fabry disease endothelial cells. Molecular genetics and metabolism 189 18707907
1991 Antibodies against human neutrophil LECAM-1 (LAM-1/Leu-8/DREG-56 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro. Blood 188 1713515
2008 Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. The Journal of experimental medicine 179 18794336
1991 Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1. The Journal of biological chemistry 176 1703529
2009 Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. Arteriosclerosis, thrombosis, and vascular biology 170 19729612
2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. American journal of human genetics 164 19913121
1990 Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions. Proceedings of the National Academy of Sciences of the United States of America 163 1689848
1996 Leukocyte adhesion to vascular endothelium induces E-selectin linkage to the actin cytoskeleton. The Journal of cell biology 162 8609175
1993 Higher-affinity oligosaccharide ligands for E-selectin. The Journal of clinical investigation 160 7680663
2004 Intermittent high glucose enhances ICAM-1, VCAM-1, E-selectin and interleukin-6 expression in human umbilical endothelial cells in culture: the role of poly(ADP-ribose) polymerase. Journal of thrombosis and haemostasis : JTH 157 15304054
2002 Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians. Atherosclerosis 157 11882337
2011 Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers. Cancer research 156 22025563
1991 Cloning of a human alpha(1,3)-fucosyltransferase gene that encodes ELFT but does not confer ELAM-1 recognition on Chinese hamster ovary cell transfectants. The Journal of biological chemistry 155 1718983
2010 Indoxyl sulfate induces leukocyte-endothelial interactions through up-regulation of E-selectin. The Journal of biological chemistry 150 20937831
1993 Divergent fates of P- and E-selectins after their expression on the plasma membrane. Molecular biology of the cell 150 7694691
2008 Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow. The Journal of biological chemistry 145 18375392
2006 The DNA sequence and biological annotation of human chromosome 1. Nature 144 16710414
1997 Co-expression of ICAM-1, VCAM-1, ELAM-1 and Hsp60 in human arterial and venous endothelial cells in response to cytokines and oxidized low-density lipoproteins. Cell stress & chaperones 142 9250400
1993 Distribution of cell adhesion molecules (ICAM-1, VCAM-1, ELAM-1) in renal tissue during allograft rejection. Transplantation 142 7681228
2002 Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or Type II diabetes. Diabetologia 140 11935152
1999 Inhibition of dextran sulphate sodium (DSS)-induced colitis in mice by intracolonically administered antibodies against adhesion molecules (endothelial leucocyte adhesion molecule-1 (ELAM-1) or intercellular adhesion molecule-1 (ICAM-1)). Clinical and experimental immunology 140 10469048
2010 Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils. Blood 138 20445017
1990 IFN-gamma regulates the expression of the adhesion molecule ELAM-1 and IL-6 production by human endothelial cells in vitro. Journal of immunology (Baltimore, Md. : 1950) 127 1697876
1992 Intercellular adhesion molecule-1 (ICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in the bronchial mucosa of normal and asthmatic subjects. The European respiratory journal 126 1379941
1993 Importance of E-selectin (ELAM-1) and sialyl Lewis(a) in the adhesion of pancreatic carcinoma cells to activated endothelium. International journal of cancer 123 7687590
1993 Serum ELAM-1 is increased in vasculitis, scleroderma, and systemic lupus erythematosus. The Journal of rheumatology 117 7687701
2024 PDGFRα+ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay. Cancer cell 113 38428409
2003 Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site involves CD62E-dependent migration but not local proliferation. The Journal of experimental medicine 112 12629067
1994 Divergent patterns of ELAM-1, ICAM-1, and VCAM-1 expression on cytomegalovirus-infected endothelial cells. Transplantation 109 7528950
1992 Endothelial cell leukocyte adhesion molecule-1 (ELAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression in gingival tissue during health and experimentally-induced gingivitis. Journal of periodontal research 108 1281230
2001 Outside-to-inside signal through the membrane TNF-alpha induces E-selectin (CD62E) expression on activated human CD4+ T cells. Journal of immunology (Baltimore, Md. : 1950) 105 11123285
1991 Gold treatment of rheumatoid arthritis decreases synovial expression of the endothelial leukocyte adhesion receptor ELAM-1. The Journal of rheumatology 98 1722512
2003 Ultrasound activates the TM ELAM-1/IL-1/NF-kappaB response: a potential mechanism for intraocular pressure reduction after phacoemulsification. Investigative ophthalmology & visual science 96 12714632
1990 Cytokine production (IL-1 alpha, IL-1 beta, and TNF alpha) and endothelial cell activation (ELAM-1 and HLA-DR) in reactive lymphadenitis, Hodgkin's disease, and in non-Hodgkin's lymphomas. An immunocytochemical study. The American journal of pathology 95 1700619
1998 Stimulation with thromboxane A2 (TXA2) receptor agonist enhances ICAM-1, VCAM-1 or ELAM-1 expression by human vascular endothelial cells. Clinical and experimental immunology 94 9649216
2009 Increased CD62e(+) endothelial microparticle levels predict poor outcome in pulmonary hypertension patients. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 90 19782291
1993 Nickel chloride and cobalt chloride, two common contact sensitizers, directly induce expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and endothelial leukocyte adhesion molecule (ELAM-1) by endothelial cells. The Journal of investigative dermatology 90 7684425
1995 Molecular cloning, expression, chromosomal assignment, and tissue-specific expression of a murine alpha-(1,3)-fucosyltransferase locus corresponding to the human ELAM-1 ligand fucosyl transferase. The Journal of biological chemistry 89 7559635
1992 Increased binding of synovial T lymphocytes from rheumatoid arthritis to endothelial-leukocyte adhesion molecule-1 (ELAM-1) and vascular cell adhesion molecule-1 (VCAM-1). The Journal of clinical investigation 84 1373738
2004 Effect of high glucose concentrations on expression of ELAM-1, VCAM-1 and ICAM-1 in HUVEC with and without cytokine activation. Physiological research 78 14984317
1991 Cytomegalovirus induced PMN adherence in relation to an ELAM-1 antigen present on infected endothelial cell monolayers. Immunology 72 1709139
1998 Over-expression of ICAM-1, VCAM-1 and ELAM-1 might influence tumor progression in colorectal cancer. International journal of cancer 71 9495363
1989 CD11/CD18-independent neutrophil adherence to inducible endothelial-leucocyte adhesion molecules (E-LAM) in vitro. Immunology 69 2570036
1996 Heat shock protein 65 induces CD62e, CD106, and CD54 on cultured human endothelial cells and increases their adhesiveness for monocytes and granulocytes. Journal of immunology (Baltimore, Md. : 1950) 66 8683139
1991 Expression of ICAM-1, VCAM-1 and ELAM-1 in angiofollicular lymph node hyperplasia (Castleman's disease): evidence for dysplasia of follicular dendritic reticulum cells. Histopathology 64 1723957
1993 Implications of de novo ELAM-1 and VCAM-1 expression in human cardiac allograft rejection. Transplantation 62 7681227
2001 Dimethylfumarate inhibits tumor-necrosis-factor-induced CD62E expression in an NF-kappa B-dependent manner. The Journal of investigative dermatology 59 11886496
1999 Up-regulation of intercellular adhesion molecule-1 (ICAM-1), endothelial leucocyte adhesion molecule-1 (ELAM-1) and class II MHC molecules on pulmonary artery endothelial cells by antibodies against U1-ribonucleoprotein. Clinical and experimental immunology 56 10209523
1992 Role of ELAM-1 in adhesion of monocytes to activated human endothelial cells. Scandinavian journal of immunology 55 1371364
1994 Coordinate regulation of Steel factor, its receptor (Kit), and cytoadhesion molecule (ICAM-1 and ELAM-1) mRNA expression in human vascular endothelial cells of differing origins. Experimental hematology 54 7507856
1992 VCAM-1-, ELAM-1-, and ICAM-1-independent adhesion of melanoma cells to cultured human dermal microvascular endothelial cells. The Journal of investigative dermatology 54 1370233
1991 Involvement of the CD11b/CD18 integrin, but not of the endothelial cell adhesion molecules ELAM-1 and ICAM-1 in tumor necrosis factor-alpha-induced neutrophil toxicity. Journal of immunology (Baltimore, Md. : 1950) 53 1719092
1990 A blocking monoclonal antibody to endothelial-leukocyte adhesion molecule-1 (ELAM1). Biochemical and biophysical research communications 53 1697461
1992 Labile proteins play a dual role in the control of endothelial leukocyte adhesion molecule-1 (ELAM-1) gene regulation. The Journal of biological chemistry 52 1382069
1993 Increased plasma levels of soluble ICAM-1 and ELAM-1 (E-selectin) during acute Plasmodium falciparum malaria. Immunology letters 50 7688346
1992 A role for ELAM-1 in the pathogenesis of MOF during septic shock. The Journal of surgical research 48 1383611
1992 Infiltration of both T cells and neutrophils in the skin is accompanied by the expression of endothelial leukocyte adhesion molecule-1 (ELAM-1): an immunohistochemical and ultrastructural study. The Journal of investigative dermatology 45 1373748
1992 Effect of NADPH oxidase inhibition on endothelial cell ELAM-1 mRNA expression. Biochemical and biophysical research communications 44 1375459
1997 Alterations in the expression of ELAM-1, ICAM-1 and VCAM-1 after in vitro infection of endothelial cells with a clinical isolate of human cytomegalovirus. Microbiology and immunology 42 9087954
1996 Rabbit vascular endothelial adhesion molecules: ELAM-1 is most elevated in acute inflammation, whereas VCAM-1 and ICAM-1 predominate in chronic inflammation. Journal of leukocyte biology 38 8975870
1994 Soluble intercellular adhesion molecule-1 (ICAM-1), endothelial leukocyte adhesion molecule-1 (ELAM-1), and tumor necrosis factor receptor (55 kDa TNF-R) in patients with acute Plasmodium falciparum malaria. Clinical immunology and immunopathology 38 7515338
1993 Cultured Kaposi's sarcoma cell lines express factor XIIIa, CD14, and VCAM-1, but not factor VIII or ELAM-1. Archives of dermatology 38 7692824
2008 Blood serum levels of vascular cell adhesion molecule (sVCAM-1), intercellular adhesion molecule (sICAM-1) and endothelial leucocyte adhesion molecule-1 (ELAM-1) in diabetic retinopathy. Clinical and experimental medicine 34 18791689
1994 Serum levels of soluble E-selectin (ELAM-1) in immune-mediated neuropathies. Neurology 34 7516056
2015 Glaucomatous MYOC mutations activate the IL-1/NF-κB inflammatory stress response and the glaucoma marker SELE in trabecular meshwork cells. Molecular vision 31 26396484
2015 TNF-α enhancement of CD62E mediates adhesion of non-small cell lung cancer cells to brain endothelium via CD15 in lung-brain metastasis. Neuro-oncology 31 26472821
2011 Association of ATP1B1, RGS5 and SELE polymorphisms with hypertension and blood pressure in African-Americans. Journal of hypertension 29 21881522
1993 Identical expression of ELAM-1, VCAM-1, and ICAM-1 in sarcoidosis and usual interstitial pneumonitis. The Journal of pathology 29 7688418
1993 Expression of the endothelial leukocyte adhesion molecule-1 (ELAM-1) on endothelial cells in experimental gingivitis in humans. Journal of periodontology 28 7685818
1992 Characterization of cDNA and genomic sequences encoding rabbit ELAM-1: conservation of structure and functional interactions with leukocytes. DNA and cell biology 28 1372169
1992 Tumour necrosis factor induction of ELAM-1 and ICAM-1 on human umbilical vein endothelial cells--analysis of tumour necrosis factor-receptor interactions. Cytokine 27 1381227
2017 CD15s/CD62E Interaction Mediates the Adhesion of Non-Small Cell Lung Cancer Cells on Brain Endothelial Cells: Implications for Cerebral Metastasis. International journal of molecular sciences 26 28698503
1996 Expression of the adhesion molecules ICAM, VCAM, and ELAM in the arteriosclerotic plaque. General & diagnostic pathology 26 8780927
1994 Expression of endothelial leukocyte adhesion molecule-1 (ELAM-1) in chronic inflammatory demyelinating polyneuropathy. Neurology 25 7514772
1997 Binding of human peripheral blood polymorphonuclear leukocytes to E-selectin (CD62E) does not promote their activation. Journal of immunology (Baltimore, Md. : 1950) 24 9218615
2011 Cytokine-dependent ELAM-1 induction and concomitant intraocular pressure regulation in porcine anterior eye perfusion culture. Investigative ophthalmology & visual science 22 20861478
2005 Genomic rearrangements on VCAM1, SELE, APEG1and AIF1 loci in atherosclerosis. Journal of cellular and molecular medicine 22 15784173
1993 Reciprocal expression of CD34 and cell adhesion molecule ELAM-1 on vascular endothelium in acute cutaneous graft-versus-host disease. The Journal of pathology 22 7688420
2008 VEGF-dependent induction of CD62E on endothelial cells mediates glioma tropism of adult haematopoietic progenitor cells. Brain : a journal of neurology 21 18689869
2005 Subcutaneous administration of collagen-polyvinylpyrrolidone down regulates IL-1beta, TNF-alpha, TGF-beta1, ELAM-1 and VCAM-1 expression in scleroderma skin lesions. Clinical and experimental dermatology 21 15663512
1995 Antisense gene suppression against human ICAM-1, ELAM-1, and VCAM-1 in cultured human umbilical vein endothelial cells. Shock (Augusta, Ga.) 20 7552771
2004 High-level endothelial E-selectin (CD62E) cell adhesion molecule expression by a lipopolysaccharide-deficient strain of Neisseria meningitidis despite poor activation of NF-kappaB transcription factor. Clinical and experimental immunology 19 14678268
1994 Immunohistochemistry of port-wine stains and normal skin with endothelium-specific antibodies PAL-E, anti-ICAM-1, anti-ELAM-1, and anti-factor VIIIrAg. Archives of dermatology 18 7517655
1991 The ligand recognized by ELAM-1 on HL60 cells is not carried by N-linked oligosaccharides. European journal of immunology 18 1721027
1996 The NF-kappa B inhibitor, tepoxalin, suppresses surface expression of the cell adhesion molecules CD62E, CD11b/CD18 and CD106. Immunology letters 17 9024987
1997 Induction of mRNAs for ICAM-1, VCAM-1, and ELAM-1 in cultured rat cardiac myocytes and myocardium in vivo. Biochemistry and molecular biology international 16 9137829
1998 ELAM selectin expression in breast carcinomas detected by automated and quantitative immunohistochemical assays. International journal of oncology 14 9538126
1995 1 alpha, 25-Dihydroxyvitamin D3 decreased ICAM-1 and ELAM-1 expressions on pulmonary microvascular endothelial cells and neutrophil motivation. The Journal of steroid biochemistry and molecular biology 14 7532002
1991 LPS and cytokine-induced endothelial cell IL-6 release and ELAM-1 expression; involvement of serum. European cytokine network 14 1721850
1994 Serum Concentration and Chemotactic Activity of E-selectin (CD62E) in Inflammatory Bowel Disease. Mediators of inflammation 11 18472945
2024 Synergistic potentiation of the anti-metastatic effect of a Ginseng-Salvia miltiorrhiza herbal pair and its biological ingredients via the suppression of CD62E-dependent neutrophil infiltration and NETformation. Journal of advanced research 10 39481643
2010 Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery. Journal of cardiothoracic and vascular anesthesia 10 20056442
2009 The role of vascular adhesion molecules PECAM-1 (CD 31), VCAM-1 (CD 106), E-selectin (CD62E) and P-selectin (CD62P) in severe porcine pancreatitis. Histology and histopathology 10 19283663
1996 Alterations in ICAM-1 and ELAM-1 expression in psoriatic lesions following various treatments. Journal of dermatological science 10 8902653
1995 Preoperative serum intercellular adhesion molecule-1 (ICAM-1) and E-selectin (endothelial cell leukocyte adhesion molecule, ELAM-1) in patients with epithelial ovarian cancer. Anticancer research 10 8572633
1994 Application of immunogold labelling for light and electron microscopic localization of endothelial leukocyte adhesion molecule 1 (ELAM-1) on cultured human endothelial cells. Micron (Oxford, England : 1993) 10 7520816
2016 Relationship of SELE A561C and G98T Variants With the Susceptibility to CAD. Medicine 9 26937892
2012 Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level. BMC medical genetics 9 23190470