Affinage

SELL

L-selectin · UniProt P14151

Length
372 aa
Mass
42.2 kDa
Annotated
2026-06-10
89 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

L-selectin (SELL/CD62L/LAM-1/Leu-8) is a leukocyte transmembrane adhesion glycoprotein that mediates the initial tethering of circulating lymphocytes, neutrophils, and monocytes to inducible endothelial ligands and thereby governs leukocyte homing and recruitment (PMID:2473156, PMID:1688580, PMID:1382103). The protein is built from an N-terminal lectin-like domain, an EGF-like domain, and two short consensus repeats homologous to complement-binding proteins, and is the human orthologue of the murine MEL-14 homing receptor (PMID:2473156). The lectin domain is necessary and sufficient for binding sialylated, sulfated carbohydrate ligands (mimicked by PPME and fucoidin), while antibody engagement of the EGF domain enhances this binding, indicating cooperativity between the two domains (PMID:1712791). Functionally, L-selectin mediates roughly half of the initial leukocyte attachment to TNF-activated endothelium and is required for optimal neutrophil transendothelial migration, recognizing an inducible, neuraminidase-sensitive carbohydrate ligand whose expression is driven by LPS, TNF-α, and IL-1β on both large-vessel and glomerular endothelium (PMID:1717567, PMID:1382103); it can pair with endothelial ELAM-1 as a counter-receptor (PMID:1713515). Leukocyte activation rapidly increases L-selectin's affinity for ligand and then triggers PKC-dependent proteolytic shedding of the molecule from the cell surface, releasing soluble L-selectin and reducing adhesive capacity (PMID:1705015, PMID:1709244, PMID:1702752). Beyond adhesion, L-selectin physically associates with the TCR/CD3 complex and acts as a signaling receptor: cross-linking augments T cell proliferation but transduces a selective inhibitory signal that blocks B cell immunoglobulin differentiation without affecting proliferation (PMID:1371790, PMID:1701799). In a rat model of chronic thromboembolic pulmonary hypertension, L-selectin pairs with endothelial podocalyxin (PODXL) to drive disease-specific neutrophil–endothelial adhesion (PMID:41568451).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1989 High

    Establishing the molecular identity and domain architecture of human L-selectin defined it as a multi-domain lectin adhesion receptor and the human counterpart of the murine MEL-14 homing receptor.

    Evidence cDNA cloning, sequence/homology analysis and functional expression

    PMID:2473156 PMID:2509939

    Open questions at the time
    • Did not resolve which carbohydrate structures the lectin domain recognizes
    • Conflicting early claims about PI-anchored versus transmembrane forms
  2. 1990 High

    Genomic mapping assigned each functional domain to discrete exons and resolved the isoform question, showing a single major transmembrane product in both lymphocytes and neutrophils.

    Evidence Genomic cloning, exon mapping, primer extension, and PNH patient controls

    PMID:1692315 PMID:1701670

    Open questions at the time
    • Glycosylation differences between neutrophil and lymphocyte forms not mechanistically explained
    • Did not identify the protease responsible for shedding
  3. 1990 High

    Linking surface L-selectin expression to HEV-binding capacity established that the receptor is required for lymphocyte homing and that activation-induced loss disables adhesion.

    Evidence Anti-LAM-1 blocking antibodies and flow cytometry after PMA stimulation

    PMID:1688580

    Open questions at the time
    • Mechanism of PMA-induced surface loss not yet defined
    • Endothelial ligand not molecularly identified
  4. 1991 High

    Mapping the carbohydrate-binding function to the lectin domain and demonstrating EGF-domain cooperativity defined the structural basis of ligand recognition.

    Evidence Chimeric selectin domain swaps, PPME/fucoidin binding assays, and mAb epitope mapping

    PMID:1712791

    Open questions at the time
    • Physiological endothelial ligand structure not defined
    • Molecular basis of lectin–EGF cooperativity unresolved
  5. 1991 High

    Showing that leukocyte activation raises L-selectin ligand affinity revealed an inside-out regulatory layer controlling adhesive strength independent of expression level.

    Evidence PPME binding assays on activated versus resting lymphocytes and neutrophils with HEV-binding readout

    PMID:1705015

    Open questions at the time
    • Signaling pathway converting activation into affinity change not defined
    • Distinct lymphocyte/neutrophil mechanisms not resolved
  6. 1991 High

    Demonstrating that activation triggers PKC-dependent proteolytic shedding established the mechanism by which leukocytes rapidly downregulate adhesion and generate soluble L-selectin.

    Evidence Flow cytometry, soluble L-selectin detection in supernatants, and PKC inhibitor (H7) experiments across cell types

    PMID:1702752 PMID:1709244

    Open questions at the time
    • Identity of the sheddase protease not determined
    • PKC-independent calcium-ionophore pathway mechanism unknown
  7. 1991 Medium

    Identifying inducible endothelial ligands and the L-selectin–ELAM-1 counter-receptor relationship placed the molecule in a CD18-independent neutrophil adhesion pathway.

    Evidence Blocking antibody adhesion assays and ELAM-1-transfected L-cell adhesion experiments

    PMID:1713515

    Open questions at the time
    • Receptor-counterreceptor interpretation is indirect from one lab
    • Direct biochemical L-selectin–ELAM-1 binding not shown
  8. 1992 High

    Extending ligand recognition to TNF-activated glomerular endothelium showed L-selectin engages inducible, sialylated, mannose-6-phosphate-inhibitable ligands across multiple endothelial beds.

    Evidence Anti-LAM-1 blocking, L-selectin-cDNA-transfected pre-B cell adhesion, neuraminidase/inhibitor and RNA/protein synthesis inhibitor treatments

    PMID:1382103

    Open questions at the time
    • Molecular identity of the glomerular endothelial ligand not defined
    • In vivo relevance to renal inflammation not tested
  9. 1992 Medium

    Discovery that L-selectin physically associates with the TCR/CD3 complex and modulates T cell proliferation revealed a signaling role beyond adhesion.

    Evidence Co-immunoprecipitation with surface radioiodination, 2D diagonal SDS-PAGE, and T cell proliferation assays

    PMID:1371790

    Open questions at the time
    • Single-lab co-IP without reciprocal independent validation
    • Downstream signaling pathway not mapped
  10. 1991 Medium

    Defining an L-selectin-transduced, differentiation-selective inhibitory signal in B cells, together with secretion of soluble suppressive factors by Leu-8+ T cells, established a immunoregulatory function for the molecule.

    Evidence Anti-Leu-8 cross-linking with B cell Ig secretion/proliferation/mRNA assays; supernatant transfer, protease treatment, and HPLC fractionation

    PMID:1701799 PMID:1711071 PMID:3156924 PMID:3920308

    Open questions at the time
    • Molecular identities of the ~44 and ~12 kDa soluble factors not determined
    • Signaling intermediates downstream of L-selectin cross-linking unknown
  11. 1992 Medium

    Correlating L-selectin shedding with reduced leukocyte adhesion in hemodialysis-induced complement activation provided in vivo confirmation that shedding alters adhesive function.

    Evidence Flow cytometry of granulocyte receptors and endothelial adherence assays in a randomized crossover clinical study

    PMID:1372668

    Open questions at the time
    • Did not separate L-selectin loss from concurrent MAC-1 upregulation as the cause
    • Mechanism of complement-triggered shedding not defined
  12. 2026 Medium

    Identification of the L-selectin–podocalyxin ligand pair in pulmonary hypertension extended L-selectin adhesion biology into disease-specific neutrophil–endothelial interactions and a candidate intervention point.

    Evidence Single-cell RNA sequencing, immunofluorescence, and PODXL knockdown in a rat CTEPH model

    PMID:41568451

    Open questions at the time
    • Direct L-selectin–PODXL binding not biochemically demonstrated
    • Findings limited to a rat model

Open questions

Synthesis pass · forward-looking unresolved questions
  • The molecular identity of the physiological inducible endothelial carbohydrate ligands and the identity of the activation-regulated sheddase remain unresolved.
  • Native endothelial ligand structures not defined
  • Sheddase enzyme not identified
  • Signaling pathway linking the cytoplasmic tail to function not mapped

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098631 cell adhesion mediator activity 5 GO:0060089 molecular transducer activity 2
Localization
GO:0005886 plasma membrane 4
Pathway
R-HSA-168256 Immune System 4 R-HSA-1500931 Cell-Cell communication 3
Partners
CD3ELAM-1PODXL
Complex memberships
TCR/CD3 complex

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1989 L-selectin (LAM-1/SELL) is a cell surface glycoprotein with a multi-domain architecture: an amino-terminal lectin-like domain, an EGF-like domain, and two short consensus repeat units homologous to C3/C4 binding proteins; its amino acid sequence is 77% homologous to the mouse lymphocyte homing receptor MEL-14, establishing it as the human orthologue involved in lymphocyte adhesion. cDNA cloning, sequence analysis, chromosomal localization The Journal of experimental medicine High 2473156
1989 The human Leu-8 antigen (L-selectin/SELL) is the human homologue of the murine MEL-14 lymph node homing receptor and can adopt both conventional transmembrane and phospholipid-anchored forms. cDNA cloning, functional expression, antigen identity comparison Nature High 2509939
1990 The LYAM-1 gene encoding L-selectin spans >30 kb, is composed of at least 10 exons: exon IV encodes the lectin-like domain, exon V the EGF-like domain, exons VI–VII the short consensus repeats, exon VIII the transmembrane region, and exons IX–X the cytoplasmic tail. A single major protein product is expressed by both lymphocytes and neutrophils; no evidence for phosphatidylinositol-anchored isoforms was found in either cell type. Genomic DNA cloning, exon mapping, primer extension, sequencing of neutrophil and lymphocyte cDNA, PNH patient analysis The Journal of biological chemistry High 1692315
1990 L-selectin (LAM-1) mediates lymphocyte binding to peripheral lymph node high endothelial venules (HEV); PMA-induced loss of LAM-1 from the lymphocyte surface correlates with loss of HEV-binding ability, establishing LAM-1 surface expression as necessary for lymphocyte homing. Anti-LAM-1 monoclonal antibody blocking of HEV binding; flow cytometry of surface expression after PMA stimulation Journal of immunology High 1688580
1991 LAM-1 (L-selectin/SELL) mediates approximately 50% of the initial attachment of both lymphocytes and neutrophils to TNF-activated endothelium under nonstatic (rotating) conditions at 4°C and is required for optimal neutrophil transendothelial migration. Adhesion requires an inducible, neuraminidase-sensitive carbohydrate-containing ligand on activated endothelium, induced by LPS, TNF-α, and IL-1β. In vitro adhesion assay with anti-LAM-1 blocking antibodies under rotating and static conditions; videomicroscopic transmigration assay; neuraminidase treatment of endothelial cells Journal of immunology High 1717567
1991 Leukocyte activation by lineage-specific stimuli dramatically increases the affinity of L-selectin (LAM-1) for its carbohydrate-based ligand PPME (phosphomannan monoester core polysaccharide), directly influencing leukocyte migration. This activation-dependent increase in affinity was distinct for lymphocytes and neutrophils. PPME binding assay on activated vs. resting lymphocytes and neutrophils; HEV binding assay with physiological stimuli Nature High 1705015
1991 The lectin domain of LAM-1 is necessary and sufficient for carbohydrate (PPME/fucoidin) binding. The EGF domain contains an epitope (LAM1-1) that, when engaged by antibody, enhances carbohydrate binding, suggesting cooperativity between the lectin and EGF domains. The LAM1-3 blocking epitope maps to the lectin domain and overlaps the carbohydrate-binding site; the LAM1-6 epitope is also in the lectin domain but does not affect carbohydrate binding. Chimeric selectin construction (LAM-1/PADGEM domain swaps), PPME/fucoidin binding assays, mAb epitope mapping, lymphocyte-HEV adhesion blocking The Journal of cell biology High 1712791
1991 L-selectin (LAM-1) is shed from the cell surface upon leukocyte activation by a proteolytic cleavage mechanism; shedding is decreased by protein kinase C (PKC) inhibitors, implicating PKC signaling in regulation of shedding. Soluble LAM-1 appears in culture medium concurrent with loss from the cell surface. Flow cytometry of surface LAM-1 after PMA stimulation; detection of soluble LAM-1 in culture supernatants; PKC inhibitor experiments Leukemia High 1709244
1990 Neutrophil L-selectin (Leu-8) has a higher and more variable molecular weight (70–120 kDa) compared to lymphocyte Leu-8 (70 kDa), consistent with differential glycosylation. During neutrophil activation, L-selectin is released from the membrane (not internalized), indicating proteolytic shedding as the mechanism of surface loss. Neutrophil L-selectin has a conventional transmembrane anchor (not PI-linked), as demonstrated by normal expression in a PNH patient. SDS-PAGE/immunoblotting, 125I-antibody tracking during activation, PI-PLC treatment, PNH patient analysis Blood High 1701670
1991 L-selectin on neutrophils (LECAM-1) and ELAM-1 on endothelium operate in the same CD18-independent adhesion pathway; anti-LECAM-1 inhibits neutrophil binding to ELAM-1-transfected L cells, suggesting LECAM-1 and ELAM-1 can function as a receptor–counterreceptor pair. Blocking antibody adhesion assays, ELAM-1-transfected L-cell adhesion assay, anti-ELAM-1 and anti-LECAM-1 combination inhibition Blood Medium 1713515
1992 L-selectin (LAM-1) on neutrophils, monocytes, and lymphocytes mediates initial attachment to TNF-activated kidney glomerular endothelial cells through a neuraminidase-sensitive, mannose-6-phosphate-inhibitable ligand whose induction requires RNA and protein synthesis, establishing that glomerular endothelium expresses an inducible L-selectin ligand analogous to those on HEV and large vessel endothelium. Anti-LAM-1 antibody blocking assay, L-selectin-cDNA-transfected pre-B cell adhesion assay, neuraminidase/inhibitor treatment, RNA/protein synthesis inhibitor experiments Journal of immunology High 1382103
1992 L-selectin (Leu-8) physically associates with the TCR/CD3 complex on human T cells: co-immunoprecipitation under mild detergent conditions co-purifies the TCR α, β, γ, δ, ε, and ζ chains with Leu-8, and on average ~18% of the TCR/CD3 complex associates with Leu-8. Cross-linking Leu-8 with OKT3 markedly augments T cell proliferation, indicating functional cooperativity. Co-immunoprecipitation with surface radioiodination, 1D and 2D diagonal SDS-PAGE, immunoblotting with anti-zeta peptide antibody, T cell proliferation assay with immobilized antibodies Journal of immunology Medium 1371790
1991 Cross-linking L-selectin (Leu-8) on B cells with immobilized anti-Leu-8 antibody directly inhibits immunoglobulin differentiation/secretion (IgM and IgG) without affecting B cell proliferation, IL-2R expression, or c-myc mRNA levels, demonstrating that L-selectin transduces a selective differentiation-inhibitory signal in B cells. Anti-Leu-8 antibody cross-linking, B cell Ig secretion assay (ELISA), proliferation assay, mRNA analysis, cytokine rescue experiments Journal of immunology Medium 1701799
1985 L-selectin (Leu-8) down-regulation during lymphocyte activation with PMA occurs rapidly; CD4+,Leu-8+ T cells mediate suppression of pokeweed mitogen-induced immunoglobulin synthesis, establishing a functional role for the Leu-8+ subset in immunoregulation. Flow cytometry of surface Leu-8 after stimulation; functional suppression assay of PWM-induced Ig synthesis with CD4+ T cell subsets Journal of immunology Medium 3156924
1990 Rapid down-regulation of L-selectin (Leu-8/TQ1) surface expression by PMA is mediated via protein kinase C (blocked by H7, a PKC inhibitor), while calcium ionophore-induced down-regulation is PKC-independent. NK cell Leu-8 expression is sensitive to PMA but not to calcium ionophore A23187, revealing cell-type-specific regulation. Flow cytometry after stimulation with PMA, calcium ionophore, PKC inhibitor (H7); comparison across T, B, and NK cells Immunology Medium 1702752
1991 Supernatants from activated CD4+,Leu-8+ T cells suppress B cell Ig production without affecting B cell proliferation; the suppressive activity is protease-sensitive and elutes by HPLC at ~44 kDa and ~12 kDa, indicating that L-selectin-bearing T cells secrete soluble immunosuppressive factors. Supernatant transfer experiments, protease treatment, HPLC fractionation, B cell Ig secretion and proliferation assays Journal of immunology Medium 1711071
1991 L-selectin functional domains are evolutionarily conserved: anti-LAM-1 mAbs that block lymphocyte binding to HEV in humans also block this function in rhesus monkey and dog, and PPME-binding activity correlates with antibody reactivity across multiple mammalian species. Species cross-reactivity of mAb panel; PPME binding assay across species; HEV adhesion blocking in primate and dog Journal of immunology Medium 1713609
1985 Treatment of B cells with anti-IgM plus B cell growth factor induces loss of Leu-8 (L-selectin) expression, and only Leu-8− B cells contain antibody-forming cell precursors in response to PWM plus T cells, linking Leu-8 down-regulation to antigen-driven B cell differentiation. Functional assays (PWM-stimulated PFC), surface phenotyping, in vitro activation with anti-IgM/BCGF Journal of immunology Medium 3920308
1992 Complement activation during hemodialysis with cellulosic membranes causes a ~2-fold decrease in L-selectin (LAM-1) surface expression on granulocytes concurrent with a ~4-fold increase in MAC-1 (CD11b/CD18) expression; granulocytes with high MAC-1 / low LAM-1 expression have significantly decreased adherence to endothelial cell monolayers, linking LAM-1 shedding to altered leukocyte adhesive function. Flow cytometry of granulocyte surface receptors; endothelial cell adherence assay; randomized crossover clinical study Kidney international Medium 1372668
1991 Lamina propria lymphocytes (LPL) are Leu-8 (L-selectin)-negative; LPL lack Leu-8 mRNA and do not re-express Leu-8 after in vitro culture or PMA treatment, indicating they are derived from circulating Leu-8-negative lymphocytes rather than representing recently activated Leu-8-positive cells. Leu-8-negative peripheral blood and LPL lymphocytes show partial methylation of an MspI site near the Leu-8 gene, consistent with prior but not current transcriptional activity. Northern blot for Leu-8 mRNA, flow cytometry, in vitro culture/re-expression experiments, Southern blot/methylation analysis Gastroenterology Medium 2044931
2026 In a rat model of chronic thromboembolic pulmonary hypertension, the Sell (L-selectin)–Podxl (podocalyxin) ligand–receptor pair mediates immune cell–endothelial cell interactions specifically in diseased animals; L-selectin promotes neutrophil adhesion and dysfunction in both pulmonary arterial and microvascular endothelial cells, and knockdown of PODXL reverses these effects. Single-cell RNA sequencing, immunofluorescence, PODXL knockdown cell-based experiments, rat CTEPH model Hypertension Medium 41568451

Source papers

Stage 0 corpus · 89 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1991 Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. Journal of immunology (Baltimore, Md. : 1950) 384 1717567
1989 Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins. The Journal of experimental medicine 334 2473156
1989 Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor. Nature 292 2509939
1991 Regulation of leukocyte migration by activation of the leukocyte adhesion molecule-1 (LAM-1) selectin. Nature 289 1705015
1990 Expression of the human leukocyte adhesion molecule, LAM1. Identity with the TQ1 and Leu-8 differentiation antigens. Journal of immunology (Baltimore, Md. : 1950) 288 1688580
1985 Functional characterization of human T lymphocyte subsets distinguished by monoclonal anti-leu-8. Journal of immunology (Baltimore, Md. : 1950) 212 3156924
1991 Antibodies against human neutrophil LECAM-1 (LAM-1/Leu-8/DREG-56 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro. Blood 188 1713515
1984 Human lymphocyte subpopulations identified by using three-color immunofluorescence and flow cytometry analysis: correlation of Leu-2, Leu-3, Leu-7, Leu-8, and Leu-11 cell surface antigen expression. Journal of immunology (Baltimore, Md. : 1950) 183 6361119
1992 Modulation of granulocyte LAM-1 and MAC-1 during dialysis--a prospective, randomized controlled trial. Kidney international 135 1372668
1986 Leu-8 and Leu-9 antigen phenotypes: immunologic criteria for the distinction of mycosis fungoides from cutaneous inflammation. Journal of the American Academy of Dermatology 131 3088069
1991 Regulation of leukocyte adhesion molecule-1 (TQ1, Leu-8) expression and shedding by normal and malignant cells. Leukemia 124 1709244
1991 Function and evolutionary conservation of distinct epitopes on the leukocyte adhesion molecule-1 (TQ-1, Leu-8) that regulate leukocyte migration. Journal of immunology (Baltimore, Md. : 1950) 124 1713609
1995 Bone marrow of patients with active multiple myeloma: angiogenesis and plasma cell adhesion molecules LFA-1, VLA-4, LAM-1, and CD44. American journal of hematology 116 7545353
1990 Human antigen-specific memory T cells express the homing receptor (LAM-1) necessary for lymphocyte recirculation. European journal of immunology 109 1695155
1985 Maturational and functional diversity of human B lymphocytes delineated with anti-Leu-8. Journal of immunology (Baltimore, Md. : 1950) 99 3920308
1991 Molecular mapping of functional domains of the leukocyte receptor for endothelium, LAM-1. The Journal of cell biology 95 1712791
1990 Leu-8/CD7 antigen expression by CD3+ T cells: comparative analysis of skin and blood in mycosis fungoides/Sézary syndrome relative to normal blood values. Journal of the American Academy of Dermatology 92 1690762
1992 Neutrophils, monocytes, and lymphocytes bind to cytokine-activated kidney glomerular endothelial cells through L-selectin (LAM-1) in vitro. Journal of immunology (Baltimore, Md. : 1950) 91 1382103
1990 Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils. The Journal of biological chemistry 86 1692315
1990 Human neutrophils release the Leu-8 lymph node homing receptor during cell activation. Blood 83 1701670
1988 Leu-8 antigen expression is diminished during cell activation but does not correlate with effector function of activated T lymphocytes. Journal of immunology (Baltimore, Md. : 1950) 76 3286763
1992 Bromelain treatment of human T cells removes CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and markedly enhances CD2-mediated T cell activation. Journal of immunology (Baltimore, Md. : 1950) 68 1281188
1987 Induction of CD4 suppressor T cells with anti-Leu-8 antibody. Journal of immunology (Baltimore, Md. : 1950) 58 2953818
2021 The American stem cell sell in 2021: U.S. businesses selling unlicensed and unproven stem cell interventions. Cell stem cell 44 34739831
1985 Expression of Leu-8 antigen, a majority T-cell marker, is uncommon in mycosis fungoides. The Journal of investigative dermatology 44 3161956
1991 Altered surface expression of CD11 and Leu 8 during human basophil degranulation. Journal of immunology (Baltimore, Md. : 1950) 43 1706397
1990 Lymphocyte activation and expression of the human leucocyte-endothelial cell adhesion molecule 1 (Leu-8/TQ1 antigen). Immunology 43 1702752
1988 CD4 positive Leu-8 negative helper-inducer T cells predominate in the human intestinal lamina propria. Journal of immunology (Baltimore, Md. : 1950) 43 2902143
1992 Association of human lymph node homing receptor (Leu 8) with the TCR/CD3 complex. Journal of immunology (Baltimore, Md. : 1950) 42 1371790
2009 Diversity of lactic acid bacteria from modified atmosphere packaged sliced cooked meat products at sell-by date assessed by PCR-denaturing gradient gel electrophoresis. Food microbiology 41 19913685
1998 LAM1 is required for dorsoventrality and lateral growth of the leaf blade in Nicotiana. Development (Cambridge, England) 40 9753678
1993 LAM-1 and FAT Genes Control Development of the Leaf Blade in Nicotiana sylvestris. The Plant cell 37 12271096
1991 Lamina propria lymphocytes are derived from circulating cells that lack the Leu-8 lymph node homing receptor. Gastroenterology 37 2044931
1988 Expression of Leu-8 surface antigen in B-cell lymphomas. Correlation with other B-cell markers. The Journal of pathology 37 3258374
1989 Differences in surface phenotype between cytolytic and non-cytolytic CD4+ T cells. MHC class II-specific cytotoxic T lymphocytes lack Leu 8 antigen and express CD2 in high density. Journal of immunology (Baltimore, Md. : 1950) 24 2468710
1985 Characterization of a T4+/Leu-8+ T cell clone that directly helps B cell Ig production by secreting B cell differentiation factor. Journal of immunology (Baltimore, Md. : 1950) 24 3923106
1992 Cytokine induction of leucocyte adhesion molecule-1 (LAM- 1) expression on chronic lymphocytic leukaemia cells. Leukemia 23 1375697
1987 Expression of the Leu-8 antigen by B-cell lymphomas. American journal of clinical pathology 22 3310610
2020 WOX9 functions antagonistic to STF and LAM1 to regulate leaf blade expansion in Medicago truncatula and Nicotiana sylvestris. The New phytologist 20 32964420
1989 Defective immunoregulation in primary biliary cirrhosis: CD4+, Leu-8+ T cells have abnormal activation and suppressor function in vitro. Hepatology (Baltimore, Md.) 20 2570740
2016 The Stem Cell Hard Sell: Report from a Clinic's Patient Recruitment Seminar. Stem cells translational medicine 19 28170181
1991 Monoclonal antibody against the human peripheral lymph node homing receptor homologue (Leu 8) inhibits B cell differentiation but not B cell proliferation. Journal of immunology (Baltimore, Md. : 1950) 19 1701799
2018 Evaluation of ITGB2 (CD18) and SELL (CD62L) genes expression and methylation of ITGB2 promoter region in patients with systemic sclerosis. Rheumatology international 18 29356883
1988 Lesional keratinocytes express OKM5, Leu-8 and Leu-11b antigens in lichen planus. Dermatologica 18 2458976
2004 An immunocytochemical mapping of methionine-enkephalin-Arg(6)-Gly(7)-Leu(8) in the human brainstem. Neuroscience 17 15464291
1988 Double labeling immunohistologic and flow cytometric analysis of human B cells with particular reference to Leu-8 expression. Human pathology 16 3262082
2023 Single cell RNA-seq resolution revealed CCR1+/SELL+/XAF+ CD14 monocytes mediated vascular endothelial cell injuries in Kawasaki disease and COVID-19. Biochimica et biophysica acta. Molecular basis of disease 15 37001702
1988 Nuclear contour irregularity correlates with Leu-9-, Leu-8- cells in benign lymphoid infiltrates of skin. An ultrastructural morphometric and quantitative immunophenotypic analysis suggesting the normal T-cell counterpart to the malignant mycosis fungoides/Sézary cell. The American Journal of dermatopathology 15 3265861
2021 SELL and IFI44 as potential biomarkers of Sjögren's syndrome and their correlation with immune cell infiltration. Genes & genetic systems 13 33883324
1997 Elevation of CD8+ CD11b+ Leu-8- T cells is associated with the humoral immunodeficiency in myeloma patients. Clinical and experimental immunology 13 9276527
1994 Reduced numbers of CD8+ T cells and B cell-expression of Leu-8 antigen in peripheral blood of patients with primary biliary cirrhosis. Hepato-gastroenterology 13 7525431
2021 Detection of Cyclospora cayetanensis on bagged pre-cut salad mixes within their shelf-life and after sell by date by the U.S. food and drug administration validated method. Food microbiology 12 33875194
1994 Impaired granulocyte oxidative burst and decreased expression of leucocyte adhesion molecule-1 (LAM-1) in patients with Wegener's granulomatosis. Clinical and experimental immunology 12 7512009
1989 Preferential loss of Leu 8-, CD45R, HLA-DR+ CD8 cell subsets during in vitro culture of mononuclear cells from human immunodeficiency virus type I (HIV)-seropositive former blood donors. Journal of clinical immunology 12 2482844
1987 Phenotype of chronic lymphocytic leukemia (CLL) B-cells. B-CLL cells express the Leu-8 antigen. Blut 12 3099866
2021 Current State of the Art of Allogeneic CAR Approaches - Pile 'Em High and Sell 'Em Cheap. Journal of pharmaceutical sciences 11 33577827
2019 Leu8 and Pro8 oxytocin agonism differs across human, macaque, and marmoset vasopressin 1a receptors. Scientific reports 11 31664130
1991 CD4+ Leu-8+ T cell supernatant activity that inhibits Ig production. Journal of immunology (Baltimore, Md. : 1950) 11 1711071
1990 The significance of Leu 8 negative T cells in lymphoid skin infiltrates: malignant transformation, selective homing or T-cell activation? The British journal of dermatology 11 2248888
2019 A Comparison of the Ability of Leu8- and Pro8-Oxytocin to Regulate Intracellular Ca2+ and Ca2+-Activated K+ Channels at Human and Marmoset Oxytocin Receptors. Molecular pharmacology 10 30739093
2015 Variants in SELL, MRPS36P2, TP63, DDB2, CACNA1H, ADAM19, GNAI1, CDH13 and GABRG2 interact to confer risk of acne in Chinese population. The Journal of dermatology 10 25573302
1995 Synthesis and opioid activities of [D-Leu-8]Dynorphin(1-8) analogs containing a reduced peptide bond, psi(CH2-NH). Chemical & pharmaceutical bulletin 10 7586080
2023 LncRNA SELL/L-selectin promotes HPV-positive HNSCC progression and drives fucoidan-mediated therapeutic strategies. Acta biomaterialia 8 37330030
2022 Systematic study of single-cell isolation from musculoskeletal tissues for single-sell sequencing. BMC molecular and cell biology 8 35883033
2022 SELL and GUCY1A1 Gene Polymorphisms in Patients with Unstable Angina. Biomedicines 8 36289756
2000 Structure-activity relationships of trout bradykinin ([Arg(0),Trp(5),Leu(8)]-bradykinin). Peptides 8 11150639
2016 Identification and measurement of staphylococcal enterotoxin-like protein I (SEll) secretion from Staphylococcus aureus clinical isolate. Journal of applied microbiology 7 27187155
1992 LAM-1/Leu 8 antigen is expressed on portal, but not on lobular intrahepatic mononuclear cells in inflammatory liver disease. Clinical and experimental immunology 7 1373353
2011 Investigation of P213S SELL gene polymorphism in type 2 diabetes mellitus and related end stage renal disease. A case-control study. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 5 22119815
1991 Multiple roles of Leu-8/MEL-14 in leukocyte adhesion and function. Immunologic research 5 1720159
2025 CDK4/6 Inhibitor Priming Enhances PD-1 Blockade via Sellhi Neutrophil-Induced Stat5a+ Progenitor Exhausted CD8+ T Cell. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 4 40936164
2024 Genotyping of Holstein Cows by SELL, MX1 and CXCR1 Gene Loci Associated With Mastitis Resistance. Reproduction in domestic animals = Zuchthygiene 4 39171501
2016 Mapping of methionine-enkephalin-arg6-gly7-leu8 in the human diencephalon. Neuroscience 4 27531857
1999 The effects of the phyllolitorin analogue [desTrp(3), Leu(8)]phyllolitorin on scratching induced by bombesin and related peptides in rats. Brain research 4 10482814
1994 Defective proliferation and regulatory function of CD4+ T cells bearing Leu-8 homing receptor in primary biliary cirrhosis. Phorbol myristate acetate enhances T-cell function. Digestive diseases and sciences 4 7515343
1989 The CD4 Leu 8- T helper cell in colonic mucosa: a quantitative and functional analysis. Clinical and experimental immunology 4 2522841
2025 HPV-independent squamous sell carcinoma of cervix: a clinicopathological, immunohistochemical, and molecular analysis of six cases. Virchows Archiv : an international journal of pathology 3 40347270
2008 [New issues in adult sickle sell disease]. Bulletin de l'Academie nationale de medecine 2 19445365
1993 Specific disengagement of cell-bound anti-LAM-1 (anti-L-selectin) antibodies by aurintricarboxylic acid. Molecular immunology 2 7505884
1993 Analysis of purine metabolic enzymes in human CD4 Leu 8- and CD4 Leu 8+ lymphocyte subpopulations. The International journal of biochemistry 2 8444317
1991 Cross-linking the Leu-8 lymph node homing receptor on B cells inhibits immunoglobulin synthesis. Immunologic research 2 1720160
1988 Peripheral T-cell lymphoma with helper T-cell phenotype (Leu 3a+ Leu 8-). Acta pathologica japonica 2 2975137
2026 Association of OPN, CXCR1 and SELL polymorphisms with total antioxidant capacity of milk in Polish Holstein-Friesian cows: a preliminary study. The Journal of dairy research 0 41502304
2026 Development and Characterization of a Novel Chronic Thromboembolic Pulmonary Hypertension Rat Model: Identifying Sell-Podxl as Potential Regulators. Hypertension (Dallas, Tex. : 1979) 0 41568451
2026 SELL Marks an Effector-Deficient CD8+ T Cell Subset That Promotes Intracerebral Hemorrhage and Responds to Rutin Therapy. Human mutation 0 41937927
2023 [Research Progress of Allogeneic Hematopoietic Stem Sell Trans-plantation in the Treatment of Adult Hemophagocytic Lympho-histiocytosis --Review]. Zhongguo shi yan xue ye xue za zhi 0 36765516
2006 [Oral squamous sell carcinoma in North-Eastern Hungary I. Epidemiology]. Fogorvosi szemle 0 17016924
2004 The outcomes of hypertransfusion in major ABO incompatible allogeneic stem sell transplantation. Journal of Korean medical science 0 14966346
2003 [IL-8 and T-lymphocytes expressing adhesion molecules LFA-1 (CD11a/CD18), Mac-1 (CD11b/CD18) Lsel in lower respiratory tract obstructive disease]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 0 12712819

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