Affinage

SOX5

Transcription factor SOX-5 · UniProt P35711

Length
763 aa
Mass
84.0 kDa
Annotated
2026-06-10
100 papers in source corpus 44 papers cited in narrative 44 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SOX5 is an HMG-box transcription factor that binds the AACAAT motif with high affinity and bends its target DNA, with its HMG box adopting a twisted L-shaped fold characteristic of sequence-specific HMG proteins (PMID:8078769, PMID:10588902, PMID:11266597). The long isoform L-SOX5 carries an N-terminal coiled-coil/leucine-zipper region that mediates homodimerization and heterodimerization with SOX6, and this dimerization sharply increases binding to DNA bearing adjacent HMG sites (PMID:9755172, PMID:9714725). Its central developmental role is in chondrogenesis: acting genetically downstream of SOX9, L-SOX5/SOX6 secure and potentiate SOX9 binding at cartilage-specific enhancers and super-enhancers genome-wide, where SOX9 recognizes inverted SOX motif pairs and SOX6 favors tandem pairs, cooperatively activating Col2a1, aggrecan, COMP, Matn1, and miR-140 together with coactivators including CBP/p300 and Tip60 (PMID:9755172, PMID:12414734, PMID:18559420, PMID:18390577, PMID:26150426). The SOX5/SOX6/SOX9 trio is sufficient to drive chondrocyte differentiation in multiple cell types, and SOX5/SOX6 are required in vivo for notochord ECM sheath formation, growth-plate chondrocyte differentiation, and synovial joint morphogenesis (PMID:12571105, PMID:15529345, PMID:20206616). Beyond cartilage, SOX5 acts as a context-dependent fate regulator: it represses SOX10 targets in the melanocyte and oligodendrocyte lineages by recruiting the corepressors CtBP2 and HDAC1 and competing for binding sites (PMID:18703590, PMID:29621239, PMID:26927636), serves as a DNA-binding cofactor that recruits BMP R-Smads (Smad1/4) to BMP target enhancers (PMID:25453832), and cooperates with c-Maf downstream of STAT3 to activate the RORγt promoter and a looped RORCE2 enhancer, driving Th17 differentiation (PMID:25073789, PMID:33473108). In progenitor populations SOX5 promotes cell-cycle exit by suppressing WNT/β-catenin signaling (PMID:20448664, PMID:28186563). In disease and cancer contexts SOX5 directly transactivates Twist1, MMP-9, RANKL, EZH2, VEGF, and GLUT4, and physically associates with YAP1, contributing to EMT, invasion, osteoclastogenesis, and metabolic reprogramming (PMID:24607904, PMID:27550416, PMID:30854049, PMID:29706965, PMID:31325096, PMID:29888108), while also driving HMGB2-mediated rejuvenation of cartilage progenitors and regulating β-cell insulin secretion (PMID:28585545, PMID:37832549).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 1994 High

    Established SOX5 as a sequence-specific DNA-binding protein, defining its core biochemical activity before any developmental role was known.

    Evidence In vitro footprinting, EMSA, CD and 2D NMR of the HMG box, with nuclear immunolocalization in spermatids

    PMID:8078769

    Open questions at the time
    • Did not define in vivo target genes
    • Tested the short testis form only, not the long isoform's full function
  2. 1998 High

    Identified the long isoform L-SOX5 and its coiled-coil dimerization domain, explaining how SOX5 cooperatively engages paired HMG sites with SOX6 and SOX9 to activate cartilage genes.

    Evidence cDNA cloning, dimerization and DNA-binding assays, Col2a1 enhancer reporter assays and transgenic embryos

    PMID:9714725 PMID:9755172

    Open questions at the time
    • Did not resolve genome-wide binding
    • Mechanism of cooperativity with SOX9 not yet structurally defined
  3. 2001 High

    Biophysically and structurally characterized the SOX5 HMG box and the thermodynamics of AACAAT recognition, distinguishing it from non-sequence-specific HMG proteins.

    Evidence Solution NMR structure with backbone dynamics, ITC, DSC and fluorescence titration

    PMID:10588902 PMID:11266597

    Open questions at the time
    • No co-crystal/co-structure with DNA in the heterodimeric context
    • Full-length protein and dimerization domain not structurally resolved
  4. 2004 High

    Placed SOX5 in the chondrogenic hierarchy downstream of SOX9 and showed the SOX trio is sufficient to drive chondrocyte differentiation, defining the in vivo developmental pathway.

    Evidence Conditional Sox9 KO epistasis, double-KO notochord analysis, and SOX trio gain-of-function across multiple cell types

    PMID:12414734 PMID:12571105 PMID:15529345

    Open questions at the time
    • Did not resolve genome-wide enhancer targets
    • Relative contributions of SOX5 vs SOX6 not separated
  5. 2010 High

    Defined the molecular mechanism of cooperative activation: L-SOX5/SOX6 bind enhancer elements and increase the efficiency of SOX9 binding and transactivation across multiple cartilage genes.

    Evidence Transgenic reporters, ChIP, EMSA and cis-element mutagenesis at Agc1, Matn1, COMP and miR-140 enhancers; ternary complex with Tip60

    PMID:17485346 PMID:18390577 PMID:18559420 PMID:21173167 PMID:22547066

    Open questions at the time
    • Stoichiometry of the SOX5/SOX6/SOX9 complex on DNA unresolved
    • Roles of individual coactivators not fully separated
  6. 2010 High

    Revealed SOX5 as a repressive modulator of SOX10 in pigment and glial lineages, switching it from activator to corepressor-recruiting factor depending on context.

    Evidence Sox5-deficient mice, ChIP for CtBP2/HDAC1 recruitment, reporter assays and Sox5/Sox10 compound mutant epistasis

    PMID:18703590 PMID:26927636 PMID:29621239

    Open questions at the time
    • Determinants of activator-vs-repressor switching not defined
    • Species-specific differences in xanthophore regulation unresolved
  7. 2010 Medium

    Extended SOX5 function to neural progenitor cell-cycle control through suppression of WNT/β-catenin signaling, linking it to proliferation/differentiation balance.

    Evidence In ovo electroporation gain/loss-of-function in chick spinal cord, WNT reporter and axin2 induction; Drosophila ortholog and human-cell WNT reporter corroboration

    PMID:20448664 PMID:23696452 PMID:28186563

    Open questions at the time
    • Direct WNT-pathway target genes of SOX5 not mapped
    • Mechanism connecting SOX5 to axin2 induction unresolved
  8. 2014 High

    Demonstrated SOX5 acts as a DNA-binding cofactor for BMP R-Smads and as a key Th17 driver via c-Maf and RORγt, establishing signaling-coupled cofactor roles beyond chondrogenesis.

    Evidence Xenopus loss-of-function with Smad1/4 ChIP and Co-IP; T cell conditional KO, Sox5/c-Maf Co-IP domain mapping, RORγt reporter and Stat3/RORγt epistasis

    PMID:25073789 PMID:25453832

    Open questions at the time
    • Genome-wide Smad-SOX5 co-occupancy not defined
    • Structural basis of the SOX5–c-Maf and SOX5–Smad interactions unknown
  9. 2015 High

    Resolved the genome-wide cooperative logic showing SOX9 and SOX5/SOX6 co-target cartilage super-enhancers, generalizing the trio mechanism across the chondrogenic genome.

    Evidence SOX6 and SOX9 ChIP-seq with motif analysis, super-enhancer mapping, and conditional KO validation; OPC migration via PDGFRα

    PMID:26150426 PMID:26345464

    Open questions at the time
    • Direct SOX5 (vs SOX6) genome-wide occupancy inferred rather than separately mapped
    • Quantitative contribution of super-enhancers to phenotype not isolated
  10. 2018 High

    Established SHOX as a physical partner cooperating with SOX5/SOX6/SOX9 at cartilage enhancers, linking SOX5 complexes to human skeletal disease via disrupted SHOX-SOX6 interaction.

    Evidence Yeast two-hybrid, reciprocal Co-IP, domain mapping with Leri-Weill dyschondrosteosis mutations and Agc1 enhancer reporters

    PMID:21262861

    Open questions at the time
    • Direct contact between SHOX and SOX5 (vs SOX6) not separately mapped
    • Genome-wide SHOX-SOX co-occupancy not defined
  11. 2021 Medium

    Showed SOX5 directly drives diverse disease-relevant target genes and physical partnerships across cancer, arthritis, metabolic and aging contexts, defining its pleiotropic transactivator roles.

    Evidence ChIP/ChIP-seq and reporter assays for Twist1, MMP-9, RANKL, EZH2, VEGF, GLUT4 and HMGB2; Co-IP with YAP1; islet electrophysiology; in vivo CIA, xenograft, glioma and aged-cartilage models

    PMID:19219070 PMID:24607904 PMID:27550416 PMID:28585545 PMID:29123266 PMID:29706965 PMID:29888108 PMID:29890823 PMID:30854049 PMID:31147293 PMID:31325096 PMID:32949698 PMID:37832549

    Open questions at the time
    • Many target relationships rest on single-lab ChIP/reporter evidence
    • Whether SOX5 acts alone or via dimerization partners in these contexts is largely untested
    • Direct vs indirect transactivation not always distinguished

Open questions

Synthesis pass · forward-looking unresolved questions
  • How SOX5 switches between cooperative activation (with SOX6/SOX9) and corepression (recruiting CtBP2/HDAC1), and which partners govern its many context-specific target programs, remains unresolved.
  • No unified model of activator/repressor switching
  • No structure of full-length SOX5 or its multiprotein DNA complexes
  • Cell-type-specific cofactor determinants undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 7 GO:0003677 DNA binding 6 GO:0060090 molecular adaptor activity 3
Localization
GO:0005634 nucleus 1
Pathway
R-HSA-1266738 Developmental Biology 5 R-HSA-74160 Gene expression (Transcription) 5 R-HSA-168256 Immune System 4 R-HSA-162582 Signal Transduction 3
Partners
C-MAFCTBP2HDAC1SHOXSOX6SOX9TIP60YAP1
Complex memberships
L-SOX5/SOX6 dimerSOX5/SOX6/SOX9 trio

Evidence

Reading pass · 44 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1994 SOX5 protein localizes to the nucleus of post-meiotic round spermatids in mouse testis. In vitro footprinting and gel retardation assays demonstrate that SOX5 binds specifically to the sequence AACAAT with ~10^-9 M affinity. Interaction of SOX5 with its target DNA induces a significant bend in the DNA, characteristic of HMG box proteins. 2D NMR analysis of the SOX5 HMG box revealed helical secondary structure and tertiary structure similar to HMG1 box 2. Indirect immunofluorescence (nuclear localization), in vitro footprinting, gel retardation assay, circular dichroism spectroscopy, 2D NMR Nucleic acids research High 8078769
1998 A new long-form L-Sox5 (distinct from the short testis form) contains a coiled-coil domain in its N-terminal part that mediates homodimerization and heterodimerization with Sox6. Dimerization of L-Sox5/Sox6 greatly increases efficiency of binding to DNA containing adjacent HMG sites. L-Sox5, Sox6, and Sox9 cooperatively activate expression of Col2a1 via a 48 bp chondrocyte-specific enhancer containing multiple HMG-like sites, which all three proteins bind. Coiled-coil domain analysis, dimerization assays, DNA binding assays, reporter gene assays in 10T1/2 and MC615 cells, transgenic mouse embryo expression The EMBO journal High 9755172
1998 The mouse Sox5 long-form cDNA (from 8.5-day embryo) encodes a 763-amino acid protein containing a leucine zipper motif and a glutamine-rich Q box domain, which are absent from the short testis-derived form (392 aa). These domains are conserved among type-D SOX proteins. cDNA cloning, sequence analysis, Southern analysis, RT-PCR Biochimica et biophysica acta Medium 9714725
1999 Thermodynamic characterization of the Sox5 HMG box interaction with AACAAT-containing DNA duplexes: association constant ~4×10^7 M^-1; binding is endothermic below 17°C and exothermic above; heat capacity change on binding ~-2 kJ K^-1 mol^-1. The binding involves dehydration of polar and non-polar groups and release of counterions, with significant conformational entropy reduction. Fluorescence titration, isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC) Journal of molecular biology High 10588902
2001 Solution NMR structure of the mouse Sox5 HMG box in free solution reveals a characteristic twisted L-shape with a major wing (helices 1 and 2) and a minor wing (helix 3 in weak antiparallel association with N-terminal strand). The minor wing shows considerable backbone mobility (reduced order parameter S²) that increases toward termini, particularly C-terminal to Q62, contrasting with non-sequence-specific HMG boxes. Multidimensional NMR with ¹⁵N-labeled protein, ¹⁵N relaxation measurements Protein science High 11266597
2002 Sox9 is required upstream of Sox5 and Sox6 expression: inactivation of Sox9 in limb bud mesenchymal cells before condensation results in complete loss of Sox5 and Sox6 expression, placing Sox9 genetically upstream of Sox5 in the chondrogenic transcription factor hierarchy. Conditional knockout using Cre/loxP recombination in mouse embryos, in situ hybridization for marker gene expression Genes & development High 12414734
2003 Sox5 and Sox6 are expressed in the notochord cell lineage and are required for notochord extracellular matrix sheath formation and notochord cell survival. In Sox5⁻/⁻;Sox6⁻/⁻ embryos, the notochord fails to become surrounded by an ECM sheath, associated with downregulation of collagen 2, aggrecan and perlecan genes; notochord cells then undergo apoptosis. Sox5/Sox6 are thus required for nucleus pulposus formation. Double knockout mouse analysis, in situ hybridization, immunohistochemistry, apoptosis assays Development (Cambridge, England) High 12571105
2004 The combination of SOX5, SOX6, and SOX9 (SOX trio) is sufficient to induce chondrocyte differentiation in embryonic stem cells, mesenchymal stem cells, non-chondrogenic immortalized cell lines, and primary dermal fibroblasts, while simultaneously suppressing hypertrophic and osteogenic differentiation. Fluorescent reporter ES cell line screen, gene transfer into multiple cell types, glycosaminoglycan assay, Safranin-O staining, marker gene expression Arthritis and rheumatism High 15529345
2007 Sox9, Sox5, and Sox6 cooperatively activate COMP gene expression via a 51-bp positive regulatory element (PRE) in the COMP promoter. Sox9 binds the COMP promoter at the PRE, requiring 13 nucleotides (TGTTTACCTTGTG). Activation by Sox9 requires participation of Sox5 and Sox6 as well as coactivators CBP and p300 histone acetylase. EMSA (gel shift), reporter assays, siRNA knockdown, co-transfection in chondrogenic cells Frontiers in bioscience Medium 17485346
2008 L-Sox5 and Sox6 promote binding of Sox9 to a far-upstream 359-bp aggrecan (Agc1) enhancer 10 kb upstream of the gene. L-Sox5/Sox6 bind three additional elements in this enhancer cooperatively, and upon binding, increase the efficiency of Sox9 binding to its own recognition site, thereby robustly potentiating Sox9-mediated transcriptional activation. A similar mechanism operates at the Col2a1 and other cartilage-specific enhancers. Transgenic mouse reporter assay, ChIP, EMSA, co-transfection reporter assays, site-directed mutagenesis of cis-elements Molecular and cellular biology High 18559420
2008 Sox5 modulates Sox10 activity in the melanocyte lineage by binding regulatory regions of melanocytic Sox10 target genes and recruiting the corepressors CtBP2 and HDAC1, directly inhibiting Sox10-dependent promoter activation. Both binding site competition and corepressor recruitment contribute to this modulatory activity. Loss of Sox5 in Sox10 heterozygous mice partially rescues melanoblast generation. Sox5-deficient mouse analysis, ChIP (Sox5 binding and CtBP2/HDAC1 recruitment to target gene regulatory regions), reporter assays, genetic epistasis (Sox5⁻/⁻;Sox10⁺/⁻ compound mutants) Nucleic acids research High 18703590
2008 Tip60 (a histone acetyltransferase) physically associates with Sox9 in chondrocytes (confirmed by yeast two-hybrid and endogenous co-immunoprecipitation), and forms a complex with Sox9, Tip60, and the Col2a1 enhancer DNA. Tip60 enhances Sox9 transcriptional activity and further increases Col2a1 promoter activity in the presence of both Sox9 and Sox5. ChIP confirms that Tip60, Sox9, and Sox5 all associate with the same Col2a1 enhancer region. Tip60 acetylates Sox9 mainly at K61, K253, K398. Yeast two-hybrid, Co-IP (endogenous complex), EMSA (ternary complex with DNA), reporter assays, ChIP, siRNA in limb-bud micromass cultures, Tip60 acetylation assays Nucleic acids research High 18390577
2010 SOX5 is expressed by neural progenitors in the chick spinal cord and is turned off as differentiation proceeds. Overexpression of SOX5 in neural progenitors causes premature cell cycle exit and prevents terminal differentiation; knockdown extends the proliferative period and causes cell death in a dorsal interneuron (dI3) population. SOX5 reduces WNT-β-catenin signaling and triggers expression of the negative pathway regulator axin2. In ovo electroporation (overexpression and knockdown) in chick spinal cord, BrdU proliferation assay, cell death assay, luciferase reporter for WNT/β-catenin signaling, qPCR EMBO reports Medium 20448664
2010 S-SOX5 (48-kDa short form expressed in tissues with motile cilia/flagella) directly binds the SPAG6 gene promoter at SOX5-binding sites and stimulates mouse and human SPAG6 promoter activity, an effect abrogated by mutation or deletion of SOX5 binding sites. S-SOX5 and FOXJ1 cooperatively activate SPAG6 promoter. Silencing of S-SOX5 by RNAi downregulates SPAG6 transcripts. ChIP and EMSA confirm direct S-SOX5 association with the SPAG6 promoter. Reporter assays (promoter-luciferase), site-directed mutagenesis of binding sites, siRNA knockdown, ChIP, EMSA The Journal of biological chemistry High 20668334
2010 L-Sox5/Sox6 and Sox9 cooperatively bind the proximal Matn1 promoter at evolutionarily conserved elements (Pe1 and Ine), with L-Sox5/Sox6 binding to the Ine initiator element modulating Sox9 transactivation in a protein dose-dependent manner, restricting Matn1 expression to the proliferative and prehypertrophic zones of the growth plate. Transgenic mouse reporter assay, EMSA, ChIP, co-transfection reporter assays, binding site mutagenesis Molecular and cellular biology High 21173167
2010 Sox5 and Sox6 are required for synovial joint morphogenesis. In complete Sox5⁻/⁻;Sox6⁻/⁻ mutants, joint development aborts early: Gdf5 and Wnt9a expression occurs normally in articular progenitors but joint cell differentiation fails and cavitation does not occur. Cell-specific inactivation using Col2Cre or Gdf5Cre shows that Sox5/Sox6 in chondrocytes are required for both growth plate and articular chondrocyte differentiation, with articular chondrocytes remaining undifferentiated (continued Gdf5 expression, loss of pancartilaginous gene expression) when Sox5/Sox6 are inactivated in specified joint cells. Complete and conditional knockout mouse analysis using Cre/loxP (Col2Cre, Gdf5Cre), in situ hybridization, immunohistochemistry Developmental biology High 20206616
2011 SHOX physically interacts with SOX5 and SOX6 (identified by yeast two-hybrid and confirmed by Co-IP in human cells). The SHOX homeodomain and SOX6 HMG domain mediate this interaction. SHOX cooperates with SOX5/SOX6 and SOX9 to activate the upstream Agc1 enhancer. Disease-causing SHOX missense mutations found in Leri-Weill dyschondrosteosis disrupt this SHOX-SOX6 interaction. Yeast two-hybrid, Co-IP in human cells, domain mapping, immunohistochemistry (coexpression in fetal growth plates), reporter assays (Agc1 enhancer), mutant analysis Human molecular genetics High 21262861
2012 L-Sox5 and Sox6 increase the efficiency of Sox9 dimeric DNA binding and boost Sox9 transactivation of the miR-140 promoter. A Sox trio response element in the proximal upstream region of pri-miR-140 is required for chondrogenic promoter activity in vivo. Reporter assays (miR-140 promoter-luciferase), binding site analysis, in vivo promoter activity assay in transgenic mice, EMSA The Journal of biological chemistry Medium 22547066
2014 Sox5 physically associates with c-Maf via the HMG domain of Sox5 and the DNA-binding domain of c-Maf. Together, Sox5 and c-Maf directly activate the RORγt promoter in CD4⁺ T cells. A novel Th17-specific isoform Sox5t is induced by Stat3 signaling. T cell-specific Sox5-deficient mice show impaired Th17 cell differentiation. Retrovirus-mediated induction of Sox5 together with c-Maf induces Th17 differentiation even in Stat3-deficient CD4⁺ T cells but not in RORγt-deficient cells, placing Sox5/c-Maf downstream of Stat3 and upstream of RORγt. T cell-specific conditional KO mice, retroviral transduction, co-immunoprecipitation (Sox5 HMG domain–c-Maf DBD interaction), RORγt promoter reporter assays, genetic epistasis (Stat3⁻/⁻ and RORγt⁻/⁻ backgrounds), EAE and DTH models The Journal of experimental medicine High 25073789
2014 Sox5 functions as a DNA-binding cofactor for BMP R-Smads in Xenopus ectoderm. Sox5 is expressed where BMP signaling is active; Sox5 loss causes patterning defects resembling loss of BMP signaling (loss of neural crest and epidermis, expansion of neural plate). Sox5 physically interacts with BMP R-Smads and is essential for recruitment of Smad1/4 to BMP regulatory elements in vivo. Xenopus embryo loss-of-function, ectoderm explant assays, co-immunoprecipitation (Sox5–BMP R-Smad interaction), ChIP (Smad1/4 recruitment to BMP target gene regulatory elements) Developmental cell High 25453832
2014 Sox5 functions as a cell-autonomous fate switch in medaka neural crest: sox5 is expressed in premigratory NCCs and differentiating xanthophores, downstream of pax7a. Loss of sox5 results in excessive leucophore formation and absence of xanthophores (ml-3 mutant phenotype). Cell transplantation demonstrates a cell-autonomous role of sox5 in the xanthophore lineage. Forward genetic screen, positional cloning (ml-3 = sox5), cell transplantation (chimera analysis), in situ hybridization, genetic epistasis (pax7a) PLoS genetics High 24699463
2014 Sox5 transactivates Twist1 expression by directly binding to the Twist1 promoter in breast cancer cells, as shown by chromatin immunoprecipitation. Depletion of Sox5 inhibits breast cancer cell proliferation, migration, and invasion, downregulates Twist1, and reverses EMT (increases E-cadherin, decreases N-cadherin, Vimentin, Fibronectin 1). ChIP (Sox5 binding to Twist1 promoter), siRNA knockdown, gain/loss-of-function in breast cancer cells, Western blot for EMT markers Biochemical and biophysical research communications Medium 24607904
2015 SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis. ChIP-seq in RCS chondrocytes reveals SOX6 binds thousands of genomic sites, frequently near SOX9 binding sites. SOX9 recognizes pairs of inverted SOX motifs; SOX6 favors pairs of tandem SOX motifs. The SOX proteins primarily target super-enhancers (SEs) linked to cartilage-specific genes including the SOX trio proteins themselves and all essential cartilage ECM components. SOX proteins are required for in vivo expression of SE-associated genes. ChIP-seq (SOX6 and SOX9 genome-wide binding), motif analysis, SE identification, conditional KO for validation of in vivo gene expression Nucleic acids research High 26150426
2015 Sox5 and Sox6 promote migration of oligodendrocyte progenitor cells by maintaining expression of PDGFRα and responsiveness to PDGF-A. In CNS-specific Sox5/Sox6 double mutants, emigration of OPCs from the ventricular zone is delayed due to reduced PDGFRα expression. Sox5 and Sox6 cooperate with Sox9 and Sox10 to activate PDGFRα expression in OPCs (a co-activator role), contrasting with their antagonistic role on myelin genes. CNS-specific conditional double KO mice, in situ hybridization, immunohistochemistry, PDGF-A responsiveness assays Glia Medium 26345464
2016 SOX5 binds to and transcriptionally activates the RANKL promoter in rheumatoid arthritis synovial fibroblasts (RA-SF). ChIP shows ~3-fold enrichment of RANKL-specific DNA in anti-SOX5 immunoprecipitate in IL-6-treated cells. IL-6 induces SOX5 upregulation, which mediates RANKL upregulation; SOX5 knockdown diminishes IL-6-mediated RANKL induction. In vivo silencing of SOX5 reduces RANKL-positive cells and bone erosion in CIA mice. ChIP (SOX5 binding to RANKL promoter), siRNA knockdown, overexpression, in vivo siRNA delivery in CIA mouse model, Western blot, luciferase reporter Scientific reports Medium 27550416
2017 SOX5 directly binds the Twist1 promoter and transcriptionally activates Twist1 to drive EMT and prostate cancer metastasis. Smad3 binds the SOX5 promoter and upregulates SOX5 expression downstream of TGF-β. Knockdown of SOX5 attenuates TGF-β-induced EMT and reduces prostate cancer cell migration and mesenchymal phenotype. Luciferase reporter assays, ChIP (Smad3 binding to SOX5 promoter; SOX5 binding to Twist1 promoter), siRNA knockdown, xenograft mouse model British journal of cancer Medium 29123266
2017 Sox5 regulates β-cell phenotype and insulin secretion: Sox5 knockdown in mouse islets induces gene expression changes similar to those in T2D and reduces depolarization-evoked Ca²⁺-influx and β-cell exocytosis. SOX5 overexpression in human T2D islets increases expression of key β-cell genes and improves glucose-stimulated insulin secretion. siRNA knockdown in mouse islets, electrophysiology (Ca²⁺ influx, exocytosis), gene expression profiling, SOX5 overexpression in human T2D donor islets, glucose-stimulated insulin secretion assay Nature communications High 28585545
2017 SOX5 suppresses PDGFB-induced glioma development predominantly in Ink4a-deficient cells by inducing acute cellular senescence. SOX5 overexpression in glioma cells reduces Akt activation and increases p27(Kip1). Inhibition of p27(Kip1) reverses the anti-proliferative and pro-senescence effects of Sox5. This defines a pathway where Sox5 suppresses oncogenic PDGFB effects via p27(Kip1) in a p19(Arf)-dependent manner. Retroviral Sox5 overexpression in primary brain cells and glioma cell lines, senescence assays, proliferation assays, Western blot (Akt, p27), p27 siRNA epistasis, in vivo glioma model Oncogene Medium 19219070
2017 SOX5 transactivates EZH2 in breast cancer: ChIP-seq and quantitative ChIP identify EZH2 as a direct downstream transcriptional target of SOX5. SOX5 overexpression increases EZH2 mRNA and protein; SOX5 knockdown decreases EZH2. The proliferative and invasive effects of SOX5 depend on EZH2 regulation. ChIP-seq (SOX5 binding at EZH2 locus), quantitative ChIP, luciferase reporter assay, siRNA knockdown, rescue experiments Oncology letters Medium 30854049
2018 SOX5 promotes migration and invasion of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis in part by directly binding the MMP-9 promoter at a specific SOX5-binding site and transcriptionally activating MMP-9. ChIP shows SOX5 binding to MMP-9 promoter; deletion of the putative SOX5 binding site abolishes promoter activation. In vivo knockdown of SOX5 in CIA mice reduces MMP-9 expression and pannus invasion. ChIP (SOX5 binding to MMP-9 promoter), luciferase reporter with site deletion mutagenesis, Transwell migration/invasion assay, siRNA knockdown, in vivo CIA mouse model with local SOX5 knockdown Frontiers in immunology High 29706965
2018 In medaka and zebrafish, Sox5 represses Sox10-dependent formation of melanocytes and iridophores (Sox5 loss in Sox10-defective fish partially rescues formation of all pigment cells in zebrafish). In medaka, Sox5 promotes xanthophore specification while Sox10 loss cooperates with Sox5 loss to reduce xanthophores. Misexpression of Sox5 in xanthophore/leucophore progenitors increases xanthophores and reduces leucophores in medaka. The mode of Sox5 function (promoting vs. repressing) in xanthophore specification differs between medaka and zebrafish. TILLING, TALEN, CRISPR/Cas9-generated sox5 and sox10 mutants in medaka and zebrafish, compound mutant analysis, sox5 misexpression, pigment cell lineage tracing PLoS genetics High 29621239
2019 SOX5 directly activates the GLUT4 promoter in ovarian cancer cells to regulate glycolysis. Apatinib suppresses SOX5 expression via the VEGFR2/AKT1/GSK3β signaling cascade, thereby reducing GLUT4-mediated glucose uptake and lactate production. SOX5 overexpression rescues apatinib-inhibited GLUT4 expression. Dual-luciferase reporter assay (GLUT4 promoter), SOX5 overexpression and shRNA knockdown, Western blot (VEGFR2/AKT1/GSK3β pathway proteins), glucose uptake and lactate production assays, xenograft IHC Cellular oncology Medium 31325096
2019 FOX-A1 directly binds the SOX5 promoter and transcriptionally upregulates SOX5 expression in lung adenocarcinoma cells. ChIP-seq and ChIP assays confirm FOX-A1 occupancy at the SOX5 promoter. SOX5 knockdown reverses chemoresistance to docetaxel by suppressing EMT. ChIP-seq, ChIP assay (FOX-A1 binding to SOX5 promoter), siRNA knockdown of FOX-A1 and SOX5, Western blot for EMT markers, cell proliferation and migration assays EBioMedicine Medium 31147293
2020 SOX5 interacts with YAP1 in non-small cell lung cancer cells to drive malignant potential. Co-immunoprecipitation demonstrates SOX5-YAP1 physical interaction. SOX5 promotes self-renewal, invasion and migration; knockdown of YAP1 attenuates these malignant processes, and SOX5 overexpression reverses the attenuated progression caused by YAP1 knockdown. Co-immunoprecipitation (SOX5-YAP1 interaction), siRNA knockdown (SOX5 and YAP1), overexpression rescue experiments, sphere formation assay, Transwell invasion/migration, xenograft mouse model American journal of cancer research Medium 29888108
2021 SOX5 activates a novel RORγt enhancer (RORCE2) in Th17 cells by directly binding to it, looping RORCE2 to the RORγt promoter. Loss of the SOX5-binding site in RORCE2 abolishes RORCE2 function and affects STAT3 binding to the RORγt locus. RORCE2 deficiency suppresses RORγt expression and Th17 differentiation, reducing EAE severity. Enhancer identification, SOX5 binding site mutagenesis, chromosomal conformation assay (looping), STAT3 ChIP, RORCE2 knockout mouse, EAE model Nature communications High 33473108
2023 SOX5 activates the HMGB2 enhancer (increasing H3K27ac and H3K4me1 marks) to upregulate HMGB2 expression, thereby promoting rejuvenation and antagonizing cellular senescence. SOX5 overexpression resets the transcription network for geroprotective genes. Lentiviral SOX5 or HMGB2 gene therapy rejuvenates cartilage and alleviates osteoarthritis in aged mice. Genome-wide CRISPRa screen in hMPCs, ChIP (SOX5 binding and H3K27ac/H3K4me1 at HMGB2 enhancer), RNA-seq, lentiviral gene therapy in aged mice, histological assessment of cartilage Cell stem cell High 37832549
2011 Sox5⁻/⁻ mice show abnormal lung development with delayed maturation before the saccular stage (as early as E16.5). Sox5 loss is associated with decreased fibronectin expression in the lung, implicating SOX5 in regulation of fibronectin-dependent branching morphogenesis. Sox5⁻/⁻ mouse histology, gene expression analysis of lung development markers including fibronectin American journal of respiratory and critical care medicine Medium 21330457
2018 SOX5 inhibits MITF expression in human melanoma cells. SOX5 knockdown leads to MITF upregulation; double knockdown of SOX5 and SOX10 shows a rescue effect on MITF levels, confirmed by MITF-promoter reporter assays. siRNA knockdown of SOX5 and SOX10 (single and double KD), MITF promoter-reporter assay, network model + experimental validation BMC medical genomics Medium 26927636
2009 In medaka, Sox5 is required for germ-cell number regulation and, through exaptation of a transposable element (Rex1 within Izanagi), de novo regulates dmrt1bY transcriptional activity during primary sex determination. Sox5 mutant medaka exhibit complete female-to-male sex reversal. Mutant analysis, regulatory element characterization (TE insertion), transgenic reporter assays for Sox5 binding to dmrt1bY regulatory element, sex reversal phenotype scoring BMC biology Medium 29378592
2017 Silencing of the Drosophila ortholog of SOX5 (Sox102F) in various neuronal subtypes causes misorientated microchaetes, shorter and less complex dendritic arbors, loss of NMJ bouton structures, impaired olfactory perception, and neurodegeneration. Silencing in the wing disrupts Wnt/wingless signaling expression pattern. In human SH-SY5Y cells, SOX5 knockdown significantly represses WNT signaling activity and alters expression of WNT-related genes. Drosophila RNAi in specific neuronal subtypes, OCT cardiac imaging, morphological analysis of neurons, luciferase WNT reporter assay in human cells, qPCR Human molecular genetics Medium 28186563
2013 Silencing of Sox102F (Drosophila SOX5 ortholog) in cardiac tissue causes significant decrease in heart rate, heart chamber size, and cardiac wall velocities, and increased cardiac wall thickness with disrupted myofibril structure. Silencing in the wing leads to increased wingless (Wnt) signaling expression and disorganization, indicating SOX5 modulates Wnt signaling in cardiac and wing development. Drosophila transgenic RNAi in heart, high-speed ultrahigh-resolution OCT imaging of Drosophila heart, wing morphology analysis, wingless immunostaining Human molecular genetics Medium 23696452
2014 miR-194 directly targets SOX5 (validated by luciferase assay) in human adipose-derived stem cells. Downregulation of miR-194 increases SOX5 and enhances chondrogenic differentiation of hASCs, while upregulation of miR-194 decreases SOX5 and inhibits chondrogenesis. Luciferase reporter assay (miR-194 targeting SOX5 3'UTR), miR-194 gain/loss-of-function, chondrogenic differentiation assays PloS one Medium 22396742
2018 SOX5 overexpression in osteogenic differentiation of hMSCs inhibits alkaline phosphatase activity and osteoblast marker genes (Collagen I, Runx2, Osterix); knockdown of SOX5 enhances osteogenic differentiation. TNF-α upregulates SOX5, and SOX5 mediates TNF-α's inhibitory effect on osteogenesis through KLF4: SOX5 overexpression increases KLF4 expression, and KLF4 knockdown abrogates the inhibitory effect of SOX5 on osteogenesis. siRNA knockdown and plasmid overexpression, ALP activity assay, gene expression (qPCR/Western blot), KLF4 siRNA epistasis, TNF-α stimulation of hMSCs from PMOP patients Molecules and cells Medium 29890823
2020 SOX5 acts as a transcriptional activator of VEGF expression in neurons: SOX5 overexpression promotes VEGF expression and activates the PI3K/AKT pathway, protecting against LPS-induced apoptosis in PC-12 cells. SOX5 binding to the VEGF promoter was confirmed by ChIP-PCR and dual-luciferase reporter assay. ChIP-PCR, dual-luciferase reporter assay (VEGF promoter), overexpression in PC-12 cells, TUNEL apoptosis assay, Western blot for PI3K/AKT pathway Gene Medium 32949698

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes & development 1412 12414734
1998 A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. The EMBO journal 662 9755172
2001 L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway. Osteoarthritis and cartilage 296 11680692
2004 The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. Arthritis and rheumatism 279 15529345
2008 L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer. Molecular and cellular biology 247 18559420
2015 The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis. Nucleic acids research 226 26150426
2009 Copy number variation in intron 1 of SOX5 causes the Pea-comb phenotype in chickens. PLoS genetics 180 19521496
2003 Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs. Development (Cambridge, England) 137 12571105
2009 The SoxD transcription factors--Sox5, Sox6, and Sox13--are key cell fate modulators. The international journal of biochemistry & cell biology 135 19647094
2014 MiR-132, miR-15a and miR-16 synergistically inhibit pituitary tumor cell proliferation, invasion and migration by targeting Sox5. Cancer letters 131 25305447
2014 Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3. The Journal of experimental medicine 109 25073789
1994 DNA binding and bending properties of the post-meiotically expressed Sry-related protein Sox-5. Nucleic acids research 108 8078769
2012 Haploinsufficiency of SOX5 at 12p12.1 is associated with developmental delays with prominent language delay, behavior problems, and mild dysmorphic features. Human mutation 92 22290657
2012 MiR-194 regulates chondrogenic differentiation of human adipose-derived stem cells by targeting Sox5. PloS one 80 22396742
2008 The transcription factor Sox5 modulates Sox10 function during melanocyte development. Nucleic acids research 78 18703590
1996 Cloning and characterization of SOX5, a new member of the human SOX gene family. Genomics 75 8812465
1999 The energetics of HMG box interactions with DNA: thermodynamics of the DNA binding of the HMG box from mouse sox-5. Journal of molecular biology 74 10588902
2008 Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5. Nucleic acids research 72 18390577
2019 Circular RNA DOCK1 promotes bladder carcinoma progression via modulating circDOCK1/hsa-miR-132-3p/Sox5 signalling pathway. Cell proliferation 71 30983072
2012 L-Sox5 and Sox6 proteins enhance chondrogenic miR-140 microRNA expression by strengthening dimeric Sox9 activity. The Journal of biological chemistry 70 22547066
2008 Myostatin (GDF-8) deficiency increases fracture callus size, Sox-5 expression, and callus bone volume. Bone 70 18852073
2017 Sox5 contributes to prostate cancer metastasis and is a master regulator of TGF-β-induced epithelial mesenchymal transition through controlling Twist1 expression. British journal of cancer 65 29123266
2001 Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 65 11585348
2011 Chondrogenesis of human mesenchymal stem cells mediated by the combination of SOX trio SOX5, 6, and 9 genes complexed with PEI-modified PLGA nanoparticles. Biomaterials 63 21333351
2011 Chondrogenesis of adipose stem cells in a porous PLGA scaffold impregnated with plasmid DNA containing SOX trio (SOX-5,-6 and -9) genes. Biomaterials 63 21421267
2011 SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung development. American journal of respiratory and critical care medicine 58 21330457
2010 Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. Developmental biology 57 20206616
2010 SOX5 controls cell cycle progression in neural progenitors by interfering with the WNT-beta-catenin pathway. EMBO reports 57 20448664
2002 Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation. Cancer research 56 11912161
2015 Transcription factors Sox5 and Sox6 exert direct and indirect influences on oligodendroglial migration in spinal cord and forebrain. Glia 55 26345464
2018 Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements. BMC biology 54 29378592
2017 Long noncoding RNA lnc-sox5 modulates CRC tumorigenesis by unbalancing tumor microenvironment. Cell cycle (Georgetown, Tex.) 54 28632999
2017 Inhibition of TDP43-Mediated SNHG12-miR-195-SOX5 Feedback Loop Impeded Malignant Biological Behaviors of Glioma Cells. Molecular therapy. Nucleic acids 54 29499929
2023 Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation. Cell stem cell 53 37832549
2010 Transcriptional regulation of an axonemal central apparatus gene, sperm-associated antigen 6, by a SRY-related high mobility group transcription factor, S-SOX5. The Journal of biological chemistry 53 20668334
2019 miR-497-5p inhibits tumor cell growth and invasion by targeting SOX5 in non-small-cell lung cancer. Journal of cellular biochemistry 51 30816573
2007 Transcriptional activation of cartilage oligomeric matrix protein by Sox9, Sox5, and Sox6 transcription factors and CBP/p300 coactivators. Frontiers in bioscience : a journal and virtual library 51 17485346
2014 Sox5 induces epithelial to mesenchymal transition by transactivation of Twist1. Biochemical and biophysical research communications 50 24607904
2018 Downregulation of miR-139-5p promotes prostate cancer progression through regulation of SOX5. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 49 30551470
2007 Preferential expression and frequent IgG responses of a tumor antigen, SOX5, in glioma patients. International journal of cancer 47 17230535
2002 Identification and characterization of the human long form of Sox5 (L-SOX5) gene. Gene 47 12406576
2019 Apatinib inhibits glycolysis by suppressing the VEGFR2/AKT1/SOX5/GLUT4 signaling pathway in ovarian cancer cells. Cellular oncology (Dordrecht, Netherlands) 46 31325096
2011 SHOX interacts with the chondrogenic transcription factors SOX5 and SOX6 to activate the aggrecan enhancer. Human molecular genetics 46 21262861
2018 Distinct interactions of Sox5 and Sox10 in fate specification of pigment cells in medaka and zebrafish. PLoS genetics 45 29621239
2018 Effect of miR-146a-5p on proliferation and metastasis of triple-negative breast cancer via regulation of SOX5. Experimental and therapeutic medicine 45 29731835
2014 Sox5 functions as a fate switch in medaka pigment cell development. PLoS genetics 45 24699463
2020 NEAT1/miR-193a-3p/SOX5 axis regulates cartilage matrix degradation in human osteoarthritis. Cell biology international 44 31868949
2015 SOX5 promotes epithelial-mesenchymal transition and cell invasion via regulation of Twist1 in hepatocellular carcinoma. Medical oncology (Northwood, London, England) 44 25572815
2011 Electroporation-mediated transfer of SOX trio genes (SOX-5, SOX-6, and SOX-9) to enhance the chondrogenesis of mesenchymal stem cells. Stem cells and development 44 21401405
2020 CircRNA CDR1as knockdown inhibits progression of non-small-cell lung cancer by regulating miR-219a-5p/SOX5 axis. Thoracic cancer 43 31917898
2020 Activation of the SOX-5, SOX-6, and SOX-9 Trio of Transcription Factors Using a Gene-Activated Scaffold Stimulates Mesenchymal Stromal Cell Chondrogenesis and Inhibits Endochondral Ossification. Advanced healthcare materials 42 32329217
2018 Transcription Factor SOX5 Promotes the Migration and Invasion of Fibroblast-Like Synoviocytes in Part by Regulating MMP-9 Expression in Collagen-Induced Arthritis. Frontiers in immunology 42 29706965
2019 FOX-A1 contributes to acquisition of chemoresistance in human lung adenocarcinoma via transactivation of SOX5. EBioMedicine 40 31147293
2016 MicroRNA-21a-5p Functions on the Regulation of Melanogenesis by Targeting Sox5 in Mouse Skin Melanocytes. International journal of molecular sciences 40 27347933
2019 Long non-coding RNA GAS5 sensitizes renal cell carcinoma to sorafenib via miR-21/SOX5 pathway. Cell cycle (Georgetown, Tex.) 39 29895198
1998 The energetics of HMG box interactions with DNA. Thermodynamic description of the box from mouse Sox-5. Journal of molecular biology 38 9710541
2014 Sox5 Is a DNA-binding cofactor for BMP R-Smads that directs target specificity during patterning of the early ectoderm. Developmental cell 37 25453832
2015 Expressions of Sox9, Sox5, and Sox13 transcription factors in mice testis during postnatal development. Molecular and cellular biochemistry 36 26045173
2012 Haploinsufficiency of SOX5, a member of the SOX (SRY-related HMG-box) family of transcription factors is a cause of intellectual disability. European journal of medical genetics 36 23220431
2017 SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells. Cancer research 34 28687615
2019 SOX5 promotes breast cancer proliferation and invasion by transactivation of EZH2. Oncology letters 33 30854049
2019 Widening of the genetic and clinical spectrum of Lamb-Shaffer syndrome, a neurodevelopmental disorder due to SOX5 haploinsufficiency. Genetics in medicine : official journal of the American College of Medical Genetics 32 31578471
2018 miR-212-3p reduced proliferation, and promoted apoptosis of fibroblast-like synoviocytes via down-regulating SOX5 in rheumatoid arthritis. European review for medical and pharmacological sciences 31 29424904
2009 Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence. Oncogene 31 19219070
2019 RETRACTED: LncRNA DANCR silence inhibits SOX5-medicated progression and autophagy in osteosarcoma via regulating miR-216a-5p. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 30 31918278
2009 DNA fingerprinting tags novel altered chromosomal regions and identifies the involvement of SOX5 in the progression of prostate cancer. International journal of cancer 30 19173284
2018 SOX5 interacts with YAP1 to drive malignant potential of non-small cell lung cancer cells. American journal of cancer research 29 29888108
2017 Silencing of the Drosophila ortholog of SOX5 leads to abnormal neuronal development and behavioral impairment. Human molecular genetics 29 28186563
2016 SOX5 is involved in balanced MITF regulation in human melanoma cells. BMC medical genomics 29 26927636
2016 Modulation of IL-6 induced RANKL expression in arthritic synovium by a transcription factor SOX5. Scientific reports 29 27550416
2015 Exome sequencing expands the mechanism of SOX5-associated intellectual disability: A case presentation with review of sox-related disorders. American journal of medical genetics. Part A 29 26111154
2010 Evolutionarily conserved, growth plate zone-specific regulation of the matrilin-1 promoter: L-Sox5/Sox6 and Nfi factors bound near TATA finely tune activation by Sox9. Molecular and cellular biology 29 21173167
2019 SP1-mediated upregulation of lncRNA ILF3-AS1 functions a ceRNA for miR-212 to contribute to osteosarcoma progression via modulation of SOX5. Biochemical and biophysical research communications 28 30819403
2017 Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes. Nature communications 28 28585545
2020 Hypoxia Activates SOX5/Wnt/β-Catenin Signaling by Suppressing MiR-338-3p in Gastric Cancer. Technology in cancer research & treatment 27 32216582
2022 Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviates ischemic/reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT pathways. Pharmacological research 26 35483515
2015 Rearrangement of chromosome bands 12q14~15 causing HMGA2-SOX5 gene fusion and HMGA2 expression in extraskeletal osteochondroma. Oncology reports 26 26043835
2013 Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography. Human molecular genetics 26 23696452
2008 Generation of mice harboring a Sox5 conditional null allele. Genesis (New York, N.Y. : 2000) 25 18543318
2021 SOX-5 activates a novel RORγt enhancer to facilitate experimental autoimmune encephalomyelitis by promoting Th17 cell differentiation. Nature communications 23 33473108
2013 Deletion 12p12 involving SOX5 in two children with developmental delay and dysmorphic features. Pediatric neurology 23 23498568
2021 A novel lncRNA SOX2OT promotes the malignancy of human colorectal cancer by interacting with miR-194-5p/SOX5 axis. Cell death & disease 22 33993197
2019 SOX5 promotes cell invasion and metastasis via activation of Twist-mediated epithelial-mesenchymal transition in gastric cancer. OncoTargets and therapy 22 31040690
2017 Construction of PLGA Nanoparticles Coated with Polycistronic SOX5, SOX6, and SOX9 Genes for Chondrogenesis of Human Mesenchymal Stem Cells. ACS applied materials & interfaces 22 28005327
2022 circ-LDLRAD3 Knockdown Reduces Cisplatin Chemoresistance and Inhibits the Development of Gastric Cancer with Cisplatin Resistance through miR-588 Enrichment-Mediated SOX5 Inhibition. Gut and liver 21 35975639
2020 Transactivation of SOX5 by Brachyury promotes breast cancer bone metastasis. Carcinogenesis 21 31713604
2023 17-DMAG ameliorates neuroinflammation and BBB disruption via SOX5 mediated PI3K/Akt pathway after intracerebral hemorrhage in rats. International immunopharmacology 20 37517381
2020 Neuroprotective effects of SOX5 against ischemic stroke by regulating VEGF/PI3K/AKT pathway. Gene 20 32949698
2018 TNF-α-Induced SOX5 Upregulation Is Involved in the Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells Through KLF4 Signal Pathway. Molecules and cells 20 29890823
2014 High levels of SOX5 decrease proliferative capacity of human B cells, but permit plasmablast differentiation. PloS one 20 24945754
1998 The mouse Sox5 gene encodes a protein containing the leucine zipper and the Q box. Biochimica et biophysica acta 20 9714725
2021 LncRNA UCC promotes epithelial-mesenchymal transition via the miR-143-3p/SOX5 axis in non-small-cell lung cancer. Laboratory investigation; a journal of technical methods and pathology 19 33824420
2018 SOX5 induces lung adenocarcinoma angiogenesis by inducing the expression of VEGF through STAT3 signaling. OncoTargets and therapy 19 30254466
2017 SOX5 promotes epithelial-mesenchymal transition in osteosarcoma via regulation of Snail. Journal of B.U.ON. : official journal of the Balkan Union of Oncology 19 28365963
2015 A maternally inherited 16p13.11-p12.3 duplication concomitant with a de novo SOX5 deletion in a male patient with global developmental delay, disruptive and obsessive behaviors and minor dysmorphic features. American journal of medical genetics. Part A 19 25847113
2014 Association study between polymorphisms of PRMT6, PEX10, SOX5, and nonobstructive azoospermia in the Han Chinese population. Biology of reproduction 19 24648396
2001 Solution structure and backbone dynamics of the DNA-binding domain of mouse Sox-5. Protein science : a publication of the Protein Society 19 11266597
2022 N6-Methyladenosine-induced miR-143-3p promotes intervertebral disc degeneration by regulating SOX5. Bone 18 35878746
2021 CircSEC24A promotes IL-1β-induced apoptosis and inflammation in chondrocytes by regulating miR-142-5p/SOX5 axis. Biotechnology and applied biochemistry 18 33751650
2017 HuR Stabilizes lnc-Sox5 mRNA to Promote Tongue Carcinogenesis. Biochemistry. Biokhimiia 18 28371600

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