Affinage

SLMAP

Sarcolemmal membrane-associated protein · UniProt Q14BN4

Round 2 corrected
Length
828 aa
Mass
95.2 kDa
Annotated
2026-04-28
96 papers in source corpus 14 papers cited in narrative 14 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SLMAP is a tail-anchored membrane protein and core component of the STRIPAK complex that functions as a scaffold linking PP2A phosphatase activity to Hippo pathway kinases, thereby governing cell growth, tissue morphogenesis, and cardiac physiology. Its N-terminal forkhead-associated (FHA) domain binds autophosphorylated MST1/2 kinases to recruit STRIPAK-associated PP2A, which dephosphorylates and inactivates MST1/2; genetic ablation of SLMAP leads to spontaneous Hippo pathway activation, while SAV1 counteracts STRIPAK by directly inhibiting its phosphatase activity (PMID:24255178, PMID:29063833). Alternatively spliced C-terminal transmembrane domains of differing hydrophobicity target cardiac SLMAP isoforms to sarcoplasmic reticulum versus mitochondrial membranes, and perturbation of SLMAP expression alters SR calcium cycling, excitation–contraction coupling, and cardiac contractility (PMID:19538755, PMID:22180652, PMID:30856349). In gut mesenchyme, SLMAP activates YAP-driven intestinal elongation by restraining MST3 kinase, as demonstrated by conditional knockout and genetic epistasis (PMID:40521668).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2004 High

    Identification of an FHA domain-containing 91 kDa SLMAP isoform at the centrosome established that SLMAP participates in cell cycle progression, not solely membrane-associated structural roles.

    Evidence GFP-reporter targeting assays, deletion-mutant analysis, and cell growth/cell cycle assays in cultured cells

    PMID:15126628

    Open questions at the time
    • Centrosomal function mechanism not defined beyond targeting requirement
    • Unclear whether centrosomal localization is STRIPAK-dependent
    • No in vivo validation of cell cycle role
  2. 2004 Medium

    Demonstration that cardiac SLMAP isoforms bear alternatively spliced transmembrane domains targeting distinct subcellular membranes (sarcolemma, T-tubules, SR) and self-assemble via coiled-coils revealed SLMAP as a potential organizer of the excitation–contraction coupling apparatus.

    Evidence Subcellular fractionation, co-immunoprecipitation for self-assembly and myosin binding in cardiac myocytes

    PMID:15591093

    Open questions at the time
    • Single-lab study; myosin interaction not independently validated
    • Functional consequence of self-assembly not tested
    • No loss-of-function data in heart at this stage
  3. 2008 High

    Systematic proteomics placed SLMAP as a core component of the STRIPAK complex alongside PP2A, striatins, Mob3, and STRIP1/2, fundamentally reframing SLMAP from a passive structural membrane protein to a signaling scaffold.

    Evidence Iterative affinity purification/mass spectrometry interaction mapping

    PMID:18782753

    Open questions at the time
    • Stoichiometry and assembly order within STRIPAK not resolved
    • Functional output of SLMAP-containing STRIPAK unclear at this point
  4. 2009 High

    Structure–function mutagenesis of the alternatively spliced tail anchors showed that overall transmembrane domain hydrophobicity is the molecular determinant governing ER vs. mitochondrial targeting, resolving how SLMAP isoform diversity maps to organelle specificity.

    Evidence GFP-fusion targeting assays with site-directed mutagenesis of transmembrane residues, confocal microscopy, subcellular fractionation

    PMID:19538755

    Open questions at the time
    • Physiological significance of mitochondrial SLMAP not established
    • No identification of membrane-insertion machinery for SLMAP tail anchors
  5. 2011 High

    Cardiac-restricted SLMAP overexpression in transgenic mice caused SR dilation, loss of SR calcium-cycling proteins, reduced calcium uptake, and progressive contractile failure, providing the first in vivo evidence that SLMAP levels directly regulate excitation–contraction coupling.

    Evidence Transgenic mouse model with echocardiography, LV pressure monitoring, calcium uptake assays, confocal imaging, biochemical fractionation

    PMID:22180652

    Open questions at the time
    • Gain-of-function only; cardiac-specific knockout not yet performed
    • Molecular mechanism linking SLMAP to SR protein expression not identified
    • Whether STRIPAK signaling mediates the cardiac phenotype unknown
  6. 2013 High

    The FHA domain of SLMAP was shown to be required for MST1/2 binding within STRIPAK, connecting SLMAP directly to Hippo pathway regulation by enabling PP2A-mediated dephosphorylation and inactivation of MST1/2.

    Evidence AP-MS Hippo interactome mapping, FHA domain deletion, co-immunoprecipitation, okadaic acid phosphatase inhibitor treatment

    PMID:24255178

    Open questions at the time
    • Structural basis of FHA–MST interaction not yet resolved
    • Whether SLMAP recognizes MST autophosphorylation sites directly not shown
  7. 2014 High

    Fungal ortholog studies confirmed deep conservation of SLMAP/FHA–STRIPAK interaction and revealed that STRIPAK subunits are required for nuclear-envelope targeting of SLMAP, establishing a conserved targeting hierarchy.

    Evidence Deletion/domain-mutant analysis, yeast two-hybrid, co-IP, structured-illumination microscopy, genetic epistasis in Sordaria macrospora

    PMID:25527523

    Open questions at the time
    • Nuclear envelope targeting mechanism not mapped to specific STRIPAK subunit
    • Whether mammalian SLMAP nuclear-envelope localization is similarly STRIPAK-dependent not tested
  8. 2017 High

    Biochemical reconstitution and SLMAP CRISPR knockout demonstrated that SLMAP-STRIPAK dephosphorylates the MST2 activation loop after binding MST2's autophosphorylated linker, while SAV1 protects MST2 by directly inhibiting STRIPAK phosphatase activity — resolving the antagonistic SAV1/STRIPAK toggle that controls Hippo kinase output.

    Evidence Crystal structure of SAV1-MST2 SARAH domain, in vitro reconstituted phosphatase assays, SLMAP CRISPR KO in human cells, co-IP, mutagenesis

    PMID:29063833

    Open questions at the time
    • Atomic-resolution structure of FHA–MST2 linker interaction still lacking
    • How membrane anchoring of SLMAP spatially constrains STRIPAK-MST2 interaction in vivo unknown
  9. 2019 Medium

    SLMAP-3 overexpression in cardiomyocytes increased calcium transients and beating rate while knockdown blunted adrenergic responsiveness, linking SLMAP-striatin signaling to the adrenergic regulation of cardiac contractility.

    Evidence AAV-mediated overexpression and shRNA knockdown in cardiomyocytes, confocal live calcium imaging, isoproterenol challenge, proteomics

    PMID:30856349

    Open questions at the time
    • Single-lab study; adrenergic signaling mechanism downstream of SLMAP-striatin not defined
    • No in vivo cardiac-specific loss-of-function data at this stage
  10. 2024 Medium

    SLMAP localizes to the nuclear envelope in neural progenitors, and overexpression prolongs mitosis and alters asymmetric division, neuronal migration, and cortical layer formation, expanding SLMAP's roles to brain development.

    Evidence In utero electroporation (OE and Cas9-KD) in developing mouse cortex, live imaging of mitosis, cortical layer analysis, behavioral testing

    PMID:38466184

    Open questions at the time
    • Nuclear-envelope isoform identity needs clarification relative to known splice variants
    • Whether mitosis-lengthening effect is STRIPAK-dependent not tested
    • Single study without independent replication
  11. 2025 High

    Conditional deletion of Slmap in gut mesenchyme revealed that SLMAP activates YAP by restraining MST3 kinase, driving intestinal elongation; genetic epistasis with Mst3 deletion confirmed SLMAP acts upstream of MST3 in this tissue.

    Evidence Mesenchyme-specific conditional KO mice, Slmap/Mst3 double KO rescue, scRNA-seq, YAP activity and proliferation assays

    PMID:40521668

    Open questions at the time
    • Whether SLMAP–MST3 interaction operates through canonical STRIPAK or a distinct complex is unresolved
    • Whether intestinal phenotype extends to adult gut homeostasis or tumorigenesis not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the atomic-resolution structure of the SLMAP FHA domain bound to MST kinase phospho-peptides, how membrane-anchored SLMAP spatially organizes STRIPAK signaling at distinct organelles, whether cardiac-specific SLMAP knockout recapitulates loss-of-function phenotypes, and the relative contributions of STRIPAK-dependent versus -independent functions across tissues.
  • No high-resolution structure of FHA–MST interaction
  • No cardiac-specific conditional knockout model reported
  • Relative contribution of STRIPAK-dependent vs. independent SLMAP functions unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 3
Localization
GO:0005783 endoplasmic reticulum 3 GO:0005635 nuclear envelope 2 GO:0005739 mitochondrion 2 GO:0005815 microtubule organizing center 1 GO:0005886 plasma membrane 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-397014 Muscle contraction 2 R-HSA-1640170 Cell Cycle 1
Partners
MOB4MST1MST2MST3PPP2CASAV1STRIP1STRN
Complex memberships
STRIPAK

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 A novel 91 kDa isoform of SLMAP containing an N-terminal forkhead-associated (FHA) domain localizes to the centrosome (MTOC) at all phases of the cell cycle. GFP-reporter experiments and deletion-mutant analysis showed that the N-terminal sequence is required for centrosomal targeting. Elevated centrosomal SLMAP caused cell death, while centrosome-targeting mutants inhibited cell growth and caused G2/M accumulation, establishing a role for SLMAP in cell cycle progression. Anti-peptide antibody immunofluorescence co-localization with γ-tubulin, GFP reporter targeting assays, deletion-mutant analysis, microtubule-disruption experiments, cell growth assays Journal of cell science High 15126628
2004 SLMAP isoforms in cardiac myocytes bear alternatively spliced C-terminal transmembrane domains that target the protein to distinct subcellular membranes (sarcolemma, T-tubules, sarcoplasmic reticulum). SLMAP can self-assemble via coiled-coil domains and binds myosin in cardiac muscle. These properties are consistent with a structural role in organizing the excitation-contraction coupling apparatus. Subcellular fractionation, co-immunoprecipitation (SLMAP self-assembly and myosin binding), isoform expression profiling, developmental expression analysis American journal of physiology. Heart and circulatory physiology Medium 15591093
2008 SLMAP is a component of the STRIPAK (striatin-interacting phosphatase and kinase) complex. SLMAP and the related proteins SIKE and FGFR1OP2 form a sub-complex within STRIPAK that is mutually exclusive with the CTTNBP2 sub-complex. STRIPAK contains PP2A catalytic and scaffolding subunits, striatins (PP2A B''' subunits), Mob3, STRIP1/2, and CCM3. Iterative affinity purification/mass spectrometry (AP-MS) interaction mapping Molecular & cellular proteomics : MCP High 18782753
2009 The two alternatively spliced tail anchors (TA1 and TA2) of SLMAP differ in hydrophobicity and determine subcellular targeting specificity: both TA1 and TA2 direct SLMAP to the endoplasmic reticulum, but TA2 additionally directs SLMAP to mitochondria. Substitution of moderately hydrophobic residues within the TA2 transmembrane region with leucine (increasing hydrophobicity to match TA1 levels) abolished mitochondrial targeting, demonstrating that overall hydrophobicity of the transmembrane domain governs organelle specificity. GFP-fusion targeting assays, site-directed mutagenesis of transmembrane domain residues, confocal microscopy, subcellular fractionation BMC cell biology High 19538755
2011 Cardiac-restricted overexpression of SLMAP1-TM2 in transgenic mice causes dilation of the SR/ER, reduced expression of SR calcium-cycling proteins (ryanodine receptor, SERCA, calsequestrin, triadin but not phospholamban), diminished calcium uptake, electrophysiological abnormalities (prolonged QT interval), and progressive deterioration of cardiac contractility, establishing SLMAP as a regulator of excitation-contraction coupling at the sarcoplasmic reticulum. Transgenic mouse model with cardiac-restricted overexpression, left ventricular pressure monitoring, echocardiography, confocal imaging, biochemical fractionation, calcium uptake assays, Western blotting American journal of physiology. Heart and circulatory physiology High 22180652
2013 The forkhead-associated (FHA) domain of SLMAP is required for its association with MST1 and MST2 kinases within the STRIPAK complex. Deletion of the SLMAP FHA domain prevented its association with MST1/2. STRIPAK-associated SLMAP recruits PP2A phosphatase activity to dephosphorylate and inactivate MST1/2, thereby negatively regulating the Hippo pathway. Affinity purification/mass spectrometry (AP-MS) of Hippo pathway interactome, domain deletion analysis, co-immunoprecipitation, phosphatase inhibitor (okadaic acid) treatment Science signaling High 24255178
2014 The fungal SLMAP homolog PRO45 in Sordaria macrospora is required for sexual propagation and cell-to-cell fusion. Its FHA domain is essential for these functions. PRO45 interacts with STRIPAK subunits PRO11 and SmMOB3, and localizes to the nuclear envelope, ER, and mitochondria. Localization to the nuclear envelope (but not mitochondria) requires STRIPAK subunits PRO11 and PRO22. Deletion and domain-mutant analysis, yeast two-hybrid and co-immunoprecipitation protein-protein interaction studies, structured-illumination microscopy (SIM), genetic epistasis with STRIPAK subunit knockouts Eukaryotic cell High 25527523
2017 SLMAP binding to autophosphorylated MST2 linker region recruits the STRIPAK complex to MST2, enabling PP2A-mediated dephosphorylation of the MST2 activation loop and thereby inactivating MST1/2 kinases. SAV1 directly binds STRIPAK and inhibits its phosphatase activity, protecting MST2 activation-loop phosphorylation. Genetic ablation of SLMAP in human cells leads to spontaneous Hippo pathway activation and reduces the requirement for SAV1. Structural studies (crystallography/biochemistry of SAV1-MST2 SARAH domain heterotetramer), in vitro phosphatase assays, co-immunoprecipitation, SLMAP CRISPR knockout in human cells, reconstituted phosphatase activity assays, mutagenesis eLife High 29063833
2019 SLMAP-3 overexpression in cardiomyocytes increases intracellular calcium transients and promotes a positive chronotropic effect that is amplified by adrenergic (isoproterenol) stimulation. SLMAP-3 was found by proteomics to interact with striatin. Knockdown of SLMAP in cardiomyocytes reduced spontaneous contractile rate and blunted adrenergic responsiveness, phenocopying heart failure. Adeno-associated viral overexpression and shRNA knockdown in cardiomyocytes, confocal live calcium imaging, isoproterenol challenge, proteomics (SLMAP-3 interactome) Canadian journal of physiology and pharmacology Medium 30856349
2019 SLMAP forms a complex with striatin (STRN) in cardiac membranes and both proteins are involved in regulating excitation-contraction coupling, caveolae, T-tubule/SR junctions, and intercalated disc biology in cardiomyocytes. Review integrating in vitro and in vivo signaling data from multiple prior experimental studies European journal of pharmacology Low 31233748
2023 miR-29b-3p directly targets SLMAP and downregulates its expression. GLP-1 receptor agonist treatment in diabetic cardiomyopathy mice upregulates miR-29b-3p, which suppresses SLMAP expression in ventricular myocardium. Inhibition of GLP-1R reversed the effects of GLP-1RA on miR-29b-3p/SLMAP, establishing a GLP-1R → miR-29b-3p → SLMAP regulatory axis in diabetic cardiomyopathy. Dual-luciferase reporter assay (miRNA target validation), quantitative RT-PCR, Western blotting, label-free proteomics, in vivo mouse DCM model with exenatide treatment Drug design, development and therapy Medium 36936522
2025 SLMAP in gut mesenchyme regulates YAP activity by directly interacting with and controlling MST3 kinase. Deletion of Slmap in gut mesenchyme impairs YAP activity, reduces intestinal epithelial cell proliferation, and causes short gut. MST3 levels increase postnatally (peaking at P14) to slow gut elongation. Concomitant deletion of Mst3 in mesenchyme partially rescues the short gut phenotype of Slmap mutants, demonstrating genetic epistasis: SLMAP acts upstream of MST3 to activate YAP-driven gut elongation. Single-cell RNA sequencing, tissue-specific conditional knockout mice (mesenchyme-specific Slmap and Mst3 deletion), genetic epistasis (double mutant rescue), YAP activity assays, cell proliferation assays Development (Cambridge, England) High 40521668
2025 SLAP (Src-Like Adaptor Protein) interacts with mLST8, a core component of mTORC2, and facilitates non-degradative ubiquitination of mLST8 at lysines 86 and 215 via the E3 ubiquitin ligase UBE3C. This ubiquitination reduces mTORC2 complex integrity and suppresses mTORC2-AKT signaling. SLAP depletion in colorectal cancer cells enhances mTORC2 activity and sensitizes xenografts to mTOR catalytic inhibitors. Co-immunoprecipitation (SLAP-mLST8 and SLAP-UBE3C interactions), site-directed mutagenesis of ubiquitination sites (K86/K215), ubiquitination assays, mTORC2 complex integrity analysis, cell invasion/growth assays, mouse xenograft model Cell death and differentiation High 41398047
2024 SLMAP (here termed Soluble-Lamin Associated Protein in the brain context) localizes to the nuclear envelope and when overexpressed causes changes in nuclear morphology and lengthening of mitosis. Overexpression in apical progenitors of the developing mouse brain alters asymmetric cell division, neurogenic commitment, and neuronal migration, resulting in imbalance between upper and deeper cortical layers and reduced subcortical projections, and reduced exploratory behavior. In utero electroporation for overexpression and Cas9-mediated knockdown in mouse brain, live imaging of mitosis duration, immunofluorescence for nuclear envelope localization, cortical layer composition analysis, behavioral testing Biology open Medium 38466184

Source papers

Stage 0 corpus · 96 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 2861 17081983
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2009 Defining the human deubiquitinating enzyme interaction landscape. Cell 1282 19615732
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2003 Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature genetics 754 14702039
2007 Large-scale mapping of human protein-protein interactions by mass spectrometry. Molecular systems biology 733 17353931
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2015 Gene essentiality and synthetic lethality in haploid human cells. Science (New York, N.Y.) 657 26472760
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2005 The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene 499 15688006
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2005 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome research 409 16344560
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2013 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Science signaling 383 24255178
2021 A proximity-dependent biotinylation map of a human cell. Nature 339 34079125
2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. PloS one 312 23251661
2008 A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Molecular & cellular proteomics : MCP 302 18782753
2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome research 285 12975309
2001 Coupling of the TCR to integrin activation by Slap-130/Fyb. Science (New York, N.Y.) 250 11567141
2000 Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. The Journal of cell biology 246 10747096
2001 Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Science (New York, N.Y.) 228 11567140
2009 An integrated workflow for charting the human interaction proteome: insights into the PP2A system. Molecular systems biology 223 19156129
1997 Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. The Journal of biological chemistry 213 9115214
2013 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nature methods 170 23455922
2020 Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2. Nature communications 167 32572027
2001 Evidence for a molecular complex consisting of Fyb/SLAP, SLP-76, Nck, VASP and WASP that links the actin cytoskeleton to Fcgamma receptor signalling during phagocytosis. Journal of cell science 164 11739662
2000 Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome research 161 11042152
2020 A High-Density Human Mitochondrial Proximity Interaction Network. Cell metabolism 148 32877691
2019 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. Nature cell biology 137 31871319
2015 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Molecular systems biology 120 25609649
2017 SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK. eLife 119 29063833
2000 Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling. The Journal of experimental medicine 92 10662792
1998 Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130. The Journal of biological chemistry 83 9748251
1999 SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling. Proceedings of the National Academy of Sciences of the United States of America 62 10449770
2000 Cutting edge: a novel function for the SLAP-130/FYB adapter protein in beta 1 integrin signaling and T lymphocyte migration. Journal of immunology (Baltimore, Md. : 1950) 60 10640723
1998 Src-like adaptor protein (Slap) is a negative regulator of mitogenesis. Current biology : CB 58 9742401
2002 Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap. Current opinion in immunology 56 11973129
2000 Functional association between SLAP-130 and SLP-76 in Jurkat T cells. The Journal of biological chemistry 52 10671560
2014 A fungal sarcolemmal membrane-associated protein (SLMAP) homolog plays a fundamental role in development and localizes to the nuclear envelope, endoplasmic reticulum, and mitochondria. Eukaryotic cell 49 25527523
2005 Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells. The Journal of biological chemistry 46 15849195
2001 Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling. The Journal of experimental medicine 46 11696592
2009 SLAP, a regulator of immunoreceptor ubiquitination, signaling, and trafficking. Immunological reviews 40 19909366
2004 A novel isoform of sarcolemmal membrane-associated protein (SLMAP) is a component of the microtubule organizing centre. Journal of cell science 40 15126628
2014 SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2. Nature communications 38 24457997
2000 Slap negatively regulates Src mitogenic function but does not revert Src-induced cell morphology changes. Molecular and cellular biology 36 10779329
2012 Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling. PloS one 35 23300935
2015 SLAP: Small Labeling Pair for Single-Molecule Super-Resolution Imaging. Angewandte Chemie (International ed. in English) 31 26201868
2012 The influence of superior labrum anterior to posterior (SLAP) repair on restoring baseline glenohumeral translation and increased biceps loading after simulated SLAP tear and the effectiveness of SLAP repair after long head of biceps tenotomy. Journal of shoulder and elbow surgery 31 22365557
2006 Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner. Proceedings of the National Academy of Sciences of the United States of America 30 17110436
2004 Molecular properties of cardiac tail-anchored membrane protein SLMAP are consistent with structural role in arrangement of excitation-contraction coupling apparatus. American journal of physiology. Heart and circulatory physiology 30 15591093
1980 The slap test for laryngeal adductory function in horses with suspected cervical spinal cord damage. Equine veterinary journal 30 7408833
2009 Hydrophobic profiles of the tail anchors in SLMAP dictate subcellular targeting. BMC cell biology 29 19538755
2002 A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling. The Journal of biological chemistry 29 11891219
2016 Lewis Acid Induced Toggle from Ir(II) to Ir(IV) Pathways in Photocatalytic Reactions: Synthesis of Thiomorpholines and Thiazepanes from Aldehydes and SLAP Reagents. ACS central science 25 28149955
2013 Src-like-adaptor protein (SLAP) differentially regulates normal and oncogenic c-Kit signaling. Journal of cell science 25 24284075
2011 Tail-anchored membrane protein SLMAP is a novel regulator of cardiac function at the sarcoplasmic reticulum. American journal of physiology. Heart and circulatory physiology 24 22180652
2014 SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice. Blood 21 25301707
2005 Endothelial dysfunction in Type 2 diabetes correlates with deregulated expression of the tail-anchored membrane protein SLMAP. American journal of physiology. Heart and circulatory physiology 20 15764684
2003 Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells. FEBS letters 20 12681493
2003 Up-regulation of SLAP in FLI-1-transformed erythroblasts interferes with EpoR signaling. Blood 19 12946994
2015 Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling. Cellular and molecular life sciences : CMLS 18 25772501
2008 Mechanism of upregulation of the inhibitory regulator, src-like adaptor protein (SLAP), by glucocorticoids in mast cells. Molecular immunology 15 19036452
2014 RTK SLAP down: the emerging role of Src-like adaptor protein as a key player in receptor tyrosine kinase signaling. Cellular signalling 14 25446260
2019 The SLMAP/Striatin complex: An emerging regulator of normal and abnormal cardiac excitation-contraction coupling. European journal of pharmacology 13 31233748
2014 SLaP mapper: a webserver for identifying and quantifying spliced-leader addition and polyadenylation site usage in kinetoplastid genomes. Molecular and biochemical parasitology 13 25111964
2011 SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice. Journal of immunology (Baltimore, Md. : 1950) 13 21248251
2010 Medial perforation of the glenoid neck following SLAP repair places the suprascapular nerve at risk: a cadaveric study. Journal of shoulder and elbow surgery 12 20951610
2023 Glucagon-Like Peptide-1 Receptor Agonist Protects Against Diabetic Cardiomyopathy by Modulating microRNA-29b-3p/SLMAP. Drug design, development and therapy 11 36936522
2015 Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population. Journal of translational medicine 11 25880194
2007 An evaluation of the anatomic basis of the O'Brien active compression test for superior labral anterior and posterior (SLAP) lesions. Journal of shoulder and elbow surgery 11 17936025
2006 A potential role for the Src-like adapter protein SLAP-2 in signaling by the colony stimulating factor-1 receptor. The FEBS journal 11 16623714
2013 Activation of EphA receptors mediates the recruitment of the adaptor protein Slap, contributing to the downregulation of N-methyl-D-aspartate receptors. Molecular and cellular biology 10 23382070
2003 Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v. Oncogene 10 12527895
1995 Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA. Genomics 10 8825655
2019 Targeting SLMAP-ALK-a novel gene fusion in lung adenocarcinoma. Cold Spring Harbor molecular case studies 9 31160357
2011 Increased expression of the tail-anchored membrane protein SLMAP in adipose tissue from type 2 Tally Ho diabetic mice. Experimental diabetes research 8 21785580
2013 SLAP deficiency increases TCR avidity leading to altered repertoire and negative selection of cognate antigen-specific CD8+ T cells. Immunologic research 7 22956467
2019 SLMAP-3 is downregulated in human dilated ventricles and its overexpression promotes cardiomyocyte response to adrenergic stimuli by increasing intracellular calcium. Canadian journal of physiology and pharmacology 6 30856349
2019 SLAP Is a Negative Regulator of FcεRI Receptor-Mediated Signaling and Allergic Response. Frontiers in immunology 6 31156621
2009 Src-like adaptor protein (SLAP) is upregulated in antigen-stimulated mast cells and acts as a negative regulator. Molecular immunology 6 19371953
2015 Intracellular cytoplasm-specific delivery of SH3 and SH2 domains of SLAP inhibits TcR-mediated signaling. Biochemical and biophysical research communications 5 25800872
2010 Roles of Src-like adaptor protein 2 (SLAP-2) in GPVI-mediated platelet activation SLAP-2 and GPVI signaling. Thrombosis research 5 20828795
2008 Well, slap my thigh: expression of surprise facilitates memory of surprising material. Emotion (Washington, D.C.) 5 18540760
2014 The stem-loop luciferase assay for polyadenylation (SLAP) method for determining CstF-64-dependent polyadenylation activity. Methods in molecular biology (Clifton, N.J.) 3 24590783
2003 Restricted expression of Slap-1 in the rodent cerebral cortex. Gene expression patterns : GEP 3 12915308
2024 Case report: Primary sarcoma of the mandible with a novel SLMAP-BRAF fusion. Frontiers in oncology 2 38606111
2013 SLAP deficiency decreases dsDNA autoantibody production. Clinical immunology (Orlando, Fla.) 2 24440645
2025 Mesenchymal SLMAP coordinates with MST3 to govern gut elongation during development. Development (Cambridge, England) 1 40521668
2025 SLAP controls mTORC2 integrity via UBE3C-mediated non-degradative mLST8 ubiquitination to suppress colorectal tumorigenesis. Cell death and differentiation 0 41398047
2024 Manipulation of the nuclear envelope-associated protein SLAP during mammalian brain development affects cortical lamination and exploratory behavior. Biology open 0 38466184
2022 Presumed Glenoid SLAP Tear in an Adolescent Football Player Belied the Presence of a Coracoid Growth Plate Fracture: A Diagnostic Conundrum. Case reports in orthopedics 0 35154839
2019 Not All SLAPs Are Created Equal: A Comparison of Patients with Planned and Incidental SLAP Repair Procedures. Advances in orthopedics 0 31781400