Affinage

MOB4

MOB-like protein phocein · UniProt Q9Y3A3

Length
225 aa
Mass
26.0 kDa
Annotated
2026-06-10
42 papers in source corpus 15 papers cited in narrative 15 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

MOB4 (Mob3/phocein) is a core structural subunit of the STRIPAK (striatin-interacting phosphatase and kinase) complex, a large PP2A-containing signaling assembly that also includes striatins, STRIP1/2, CCM3, and GCK III family kinases (PMID:18782753). Within striatin, MOB4 binds at two distinct regions and is positioned proximal to both the STE20-family kinase-binding site and PP2A, where striatin-associated PP2A negatively regulates the associated kinase activity (PMID:21985334). Cryo-EM of the human STRIPAK core places one MOB4 within an elongated homotetrameric STRN3 scaffold bridging a single PP2AA-C heterodimer and STRIP1, and interface mutations that disrupt complex integrity cause aberrant Hippo pathway activation (PMID:33633399). Through this architecture MOB4 inhibits Hippo/MST/LATS signaling to activate YAP/TAZ: it forms a phosphorylation-dependent complex with MST4 that competitively disrupts the tumor-suppressor MST1-MOB1 pairing and drives pro-oncogenic growth and migration (PMID:30072378), bypasses oncogene-induced senescence as a Hippo inhibitor (PMID:35046109), and acts downstream of Rac1 in Schwann cells to control YAP/TAZ-dependent gene expression during peripheral nerve development (PMID:40056414). MOB4-dependent YAP activation also orients collective cell migration, with MOB4 relocalizing to the leading edge of migrating cells (PMID:41276909). Beyond Hippo signaling, MOB4 governs cytoskeletal biogenesis and organization: it acts through the actin-folding chaperonin TRiC to control actin and tubulin-dependent myofibril growth (PMID:35737712), organizes microtubule networks and axonal transport (PMID:20392941), and focuses kinetochore fibers at mitotic spindle poles (PMID:18388316). These activities support conserved developmental roles in neural stem cell reactivation (PMID:31167138), Wnt-dependent body axis scaling (PMID:31928872), and spermatogenesis (PMID:37259670), with human MOB4 transgenes rescuing invertebrate loss-of-function phenotypes (PMID:20392941, PMID:37259670).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2008 High

    Establishing MOB4's molecular context: it was unknown what assembly MOB4 belonged to, and AP-MS placed it as a stable subunit of the PP2A-containing STRIPAK complex.

    Evidence Iterative affinity purification/mass spectrometry identifying STRIPAK subunits

    PMID:18782753

    Open questions at the time
    • Did not resolve MOB4's spatial position or direct contacts within the complex
    • No functional consequence of MOB4 within STRIPAK established
  2. 2008 Medium

    It was unclear whether MOB4 had a role outside steady-state complexes; localization and RNAi showed it focuses kinetochore fibers at mitotic spindle poles, revealing a cytoskeletal function.

    Evidence RNAi knockdown, time-lapse microscopy, and GFP-fusion localization in Drosophila

    PMID:18388316

    Open questions at the time
    • Molecular partners mediating spindle pole focusing not identified
    • Relationship to STRIPAK not addressed
  3. 2010 High

    Whether MOB4 had a conserved physiological role in neurons was unknown; loss-of-function alleles tied it to axonal transport, microtubule organization, and synapse formation, with human transgene rescue establishing conservation.

    Evidence Null/hypomorphic alleles, in vivo live imaging, and human phocein rescue in Drosophila

    PMID:20392941

    Open questions at the time
    • Direct molecular mechanism linking MOB4 to microtubule/transport machinery not defined
    • STRIPAK dependence of neuronal phenotypes not tested
  4. 2011 High

    How MOB4 is positioned relative to the regulatory enzymes was unresolved; structure-function mapping localized MOB4 binding to two striatin regions near both the kinase-binding site and PP2A, implying a regulatory role in kinase dephosphorylation.

    Evidence Striatin deletion/point mutants, Co-IP, and in-cell phosphorylation assays

    PMID:21985334

    Open questions at the time
    • Direct enzymatic effect of MOB4 on PP2A or kinase activity not isolated
    • Whether MOB4 binding is required for PP2A-mediated kinase regulation untested
  5. 2013 Medium

    Whether MOB4 is itself a regulated node was unknown; in Neurospora, MAK-2-dependent phosphorylation of MOB-3's N-terminus controls nuclear-envelope STRIPAK assembly and downstream MAP kinase nuclear accumulation.

    Evidence Genetic/biochemical analysis, live cell imaging, and phosphorylation assays in Neurospora crassa

    PMID:24028079

    Open questions at the time
    • Conservation of MOB4 phosphoregulation in animals not shown
    • Direct phospho-site consequences on complex assembly not defined
  6. 2018 High

    How MOB4 modulates Hippo signaling was unclear; structural and competition experiments showed MST4-MOB4 mimics the MST1-MOB1 interface and competitively disrupts the tumor-suppressor complex to activate YAP.

    Evidence Co-IP, structure-guided analysis, competitive complex disruption, and migration/proliferation assays in PANC-1 cells

    PMID:30072378

    Open questions at the time
    • Quantitative contribution of competition versus STRIPAK-PP2A activity not separated
    • In vivo tumor relevance not established in this study
  7. 2019 Medium

    Whether MOB4-STRIPAK governs developmental cell-state transitions was untested; in Drosophila it inhibits Hippo via PP2A recruitment to enable neural stem cell reactivation, integrating Hippo and InR/PI3K/Akt inputs.

    Evidence Single-NSC transcriptomics, genetic loss-of-function, co-complex recruitment, and epistasis in Drosophila

    PMID:31167138

    Open questions at the time
    • Direct biochemical demonstration of MOB4-driven PP2A recruitment to Hippo not shown
    • Crosstalk node with InR/PI3K not molecularly defined
  8. 2020 Medium

    Whether MOB4 controls tissue-scale patterning was unknown; planarian RNAi showed it represses a posterior Wnt signaling center to scale body axis through stem cell differentiation.

    Evidence RNAi, wnt1-epistasis, and stem cell ablation in planarians

    PMID:31928872

    Open questions at the time
    • Mechanistic link between STRIPAK and Wnt center expansion not defined
    • Whether this acts via Hippo/YAP not addressed
  9. 2022 Medium

    The basis of MOB4's cytoskeletal phenotypes was unresolved; zebrafish genetics showed it acts through the TRiC chaperonin to control actin and tubulin folding, explaining both myofibril and microtubule defects.

    Evidence Forward/reverse genetics, transgenic overexpression, and TRiC genetic interaction in zebrafish

    PMID:35737712

    Open questions at the time
    • Direct physical MOB4-TRiC interaction not biochemically demonstrated
    • Whether this is STRIPAK-dependent or independent unclear
  10. 2022 Medium

    Whether MOB4 functionally diverges from canonical MOB1 was unknown; a senescence-bypass screen showed MOB3/MOB4 uniquely inhibit Hippo/MST/LATS to sustain proliferation, with membrane localization phenocopying YAP elevation.

    Evidence OIS-bypass library screen, localization constructs, and cancer line knockdown

    PMID:35046109

    Open questions at the time
    • Mechanism of membrane-localized MOB3 action not defined
    • Distinction between MOB3 family members not fully resolved
  11. 2021 High

    The architecture of MOB4 within human STRIPAK was unknown; cryo-EM resolved a single MOB4 within a homotetrameric STRN3 scaffold linked to PP2AA-C and STRIP1, with interface mutations causing aberrant Hippo activation.

    Evidence 3.2-Å cryo-EM, interface mutagenesis, and Hippo activity assays

    PMID:33633399

    Open questions at the time
    • Conformational/catalytic role of MOB4 within the assembly not mechanistically dissected
    • How substrate kinases dock onto this architecture not resolved
  12. 2023 Medium

    MOB4's broader proximity interactome and its distinction from paralogs were undefined; BioID mapped MOB4's network and confirmed STRIPAK interactions while separating it from MOB3C's RNase P association.

    Evidence BioID proximity labeling with AP-MS validation in HeLa/HEK293

    PMID:37536630

    Open questions at the time
    • Functional significance of novel proximity partners untested
    • Direct versus proximity-only contacts not distinguished
  13. 2023 Medium

    Whether MOB4 has a tissue-specific organismal requirement was unknown; Drosophila RNAi showed it is required for male fertility via spermatid individualization, axonemal microtubule integrity, and mitochondrial organization, rescued by human MOB4.

    Evidence RNAi, transmission electron microscopy, and human transgene rescue in Drosophila

    PMID:37259670

    Open questions at the time
    • Molecular target driving axonemal/mitochondrial defects not identified
    • Whether Hippo or cytoskeletal arm dominates not separated
  14. 2023 Medium

    How MOB4 directs cell migration was unclear; CRISPR KO showed it orients collective migration through YAP1 activation, with leading-edge relocalization and rescue by constitutively active YAP1.

    Evidence CRISPR/Cas9 KO, wound-healing assay, live imaging, and YAP1 rescue in MCF10A

    PMID:41276909

    Open questions at the time
    • Signal triggering MOB4 edge relocalization not defined
    • Link between migration role and STRIPAK architecture not established
  15. 2025 Medium

    The upstream input to MOB4-STRIPAK in nerve development was unknown; Schwann-cell studies identified STRN3/MOB4 as Rac1 interactors required for YAP/TAZ activation and ECM-receptor gene expression during radial sorting.

    Evidence Co-IP and conditional Schwann-cell knockouts with YAP/TAZ phosphorylation readouts

    PMID:40056414

    Open questions at the time
    • Direct MOB4-Rac1 contact versus indirect not resolved
    • Mechanism by which Rac1 modulates STRIPAK activity not defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • How MOB4 mechanistically toggles between its STRIPAK/Hippo-regulatory role and its TRiC-linked cytoskeletal role, and what governs context-specific partner choice (MST4 competition, Rac1 input, leading-edge relocalization), remains unresolved.
  • No reconstitution defining MOB4's direct effect on PP2A catalytic output
  • Direct MOB4-TRiC physical interaction unproven
  • Determinants of MOB4 subcellular relocalization unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 3 GO:0098772 molecular function regulator activity 3 GO:0140096 catalytic activity, acting on a protein 3 GO:0060090 molecular adaptor activity 2
Localization
GO:0005634 nucleus 2 GO:0005856 cytoskeleton 2 GO:0005886 plasma membrane 2 GO:0005635 nuclear envelope 1 GO:0005815 microtubule organizing center 1
Pathway
R-HSA-1266738 Developmental Biology 4 R-HSA-162582 Signal Transduction 4 R-HSA-1643685 Disease 2 R-HSA-1640170 Cell Cycle 1
Partners
MST4PP2ARAC1STRIP1STRN3TRIC
Complex memberships
STRIPAK

Evidence

Reading pass · 15 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 MOB4 (Mob3/phocein) was identified as a stable component of the STRIPAK (striatin-interacting phosphatase and kinase) complex by affinity purification/mass spectrometry. The complex contains PP2A catalytic and scaffolding subunits, striatins, STRIP1/2, CCM3, and GCK III family kinases, establishing MOB4 as part of a large PP2A-containing signaling assembly. Iterative affinity purification / mass spectrometry (AP-MS) Molecular & cellular proteomics : MCP High 18782753
2011 Striatin binds MOB4 (Mob3) at two distinct regions: one N-terminal region including the coiled-coil domain, and one more C-terminal region including the WD-repeat domain. PP2A associates with the coiled-coil/oligomerization domain of striatin and requires striatin oligomerization. Disruption of PP2A binding to striatin causes hyperphosphorylation and activation of striatin-associated Mst3 kinase, establishing that striatin-associated PP2A negatively regulates Mst3 activity and that MOB4 is positioned proximal to both the Mst3-binding site and PP2A, consistent with a regulatory role. Structure-function analysis of striatin (deletions, point mutations), Co-immunoprecipitation, in-cell phosphorylation assays BMC biochemistry High 21985334
2010 Drosophila MOB4 (DMob4/Phocein) regulates axonal transport, microtubule network organization, neurite elongation, and synapse formation. Loss-of-function null and hypomorphic alleles show overgrowth of synaptic boutons (similar to endocytotic mutants), defective axonal transport, and disorganized microtubule networks in neurons. Human phocein transgene rescues DMob4 mutant lethality, demonstrating conserved function. Null and hypomorphic allele generation, in vivo live imaging, genetic rescue with human transgene, RNAi genome-wide screen The Journal of neuroscience : the official journal of the Society for Neuroscience High 20392941
2008 Drosophila Mob4 localizes to the nucleus during interphase and to spindle poles and kinetochores during mitosis. RNAi depletion of Mob4 causes kinetochore fibers (K fibers) to splay apart and fail to maintain focus at spindle poles, both in the presence and absence of functional centrosomes, establishing a role in mitotic spindle pole organization. RNAi knockdown, time-lapse microscopy, GFP-fusion localization Journal of cell science Medium 18388316
2018 MST4 forms a complex with MOB4 in a phosphorylation-dependent manner. The overall structure of the MST4-MOB4 complex resembles that of the MST1-MOB1 complex, but diverged key interface residues allow MST4-MOB4 to disrupt MST1-MOB1 complex assembly through alternative pairing, thereby increasing YAP activity. The MST4-MOB4 complex promotes growth and migration of PANC-1 cells (pro-oncogenic), in contrast to the tumor-suppressor MST1-MOB1 complex. Co-immunoprecipitation, structural comparison (crystal structure-guided analysis), cell migration/proliferation assays, competitive complex disruption assay The Journal of biological chemistry High 30072378
2021 Cryo-EM structure of the human STRIPAK core (PP2AA, PP2AC, STRN3, STRIP1, MOB4) was determined at 3.2-Å resolution. Unlike canonical trimeric PP2A, STRIPAK contains four copies of STRN3 forming an elongated homotetrameric scaffold that links the complex together, one PP2AA-C heterodimer, one STRIP1, and one MOB4. An inositol hexakisphosphate (IP6) was identified as a structural cofactor of STRIP1. Mutations at key subunit interfaces disrupt STRIPAK integrity and cause aberrant Hippo pathway activation. Cryo-EM structure determination at 3.2 Å, interface mutagenesis, Hippo pathway activity assays Nature structural & molecular biology High 33633399
2019 In Drosophila, Mob4 and Cka (STRIPAK components) are required for neural stem cell (NSC) reactivation from quiescence. Increased Mob4 and Cka levels recruit PP2A/Mts into a complex with Hippo kinase, resulting in Hippo pathway inhibition and enabling NSC reactivation. MOB4 thus functions as part of a molecular switch coordinating Hippo and InR/PI3K/Akt pathways. Transcriptome analysis of individual NSCs, genetic loss-of-function, co-complex recruitment assay, epistasis analysis Cell reports Medium 31167138
2020 In planarians, RNAi inhibition of mob4 dramatically increases posterior body length through expansion of a posterior wnt1+ signaling center in midline muscle cells. This expansion is stem cell-dependent, establishing that MOB4 (as part of STRIPAK) represses Wnt signaling for body axis scaling through control of stem cell differentiation. RNAi knockdown, epistasis (wnt1 RNAi epistatic to mob4 RNAi), stem cell ablation experiments Current biology : CB Medium 31928872
2022 In zebrafish, loss of mob4 (nonsense mutation) causes impaired actin biogenesis resulting in sarcomere defects and reduced myofibril content, while transgenic overexpression of mob4 increases myofibril content. Genetic interaction analysis revealed that Mob4 acts through the actin-folding chaperonin TRiC to control actin biogenesis and myofibril growth. mob4 mutants also show defective microtubule networks, consistent with TRiC's role in tubulin folding. strn3-deficient mutants show similar characteristics, confirming Mob4 as a STRIPAK core component. Forward genetic screen, reverse genetics (nonsense mutant), transgenic overexpression, genetic interaction analysis with TRiC PLoS genetics Medium 35737712
2022 MOB3A (an alias for MOB4) bypasses oncogene-induced senescence (OIS) by inhibiting Hippo/MST/LATS signaling. Constitutive membrane localization of MOB3A phenocopies OIS bypass seen with elevated YAP expression. MOB3A and MOB3C (but not canonical MOB1A/B) uniquely permit primary cell proliferation under sustained oncogene signaling. Inhibition of MOB3 family members decreases proliferation and tumor growth of cancer cell lines. Library screen for OIS bypass, constitutively active localization constructs, cancer cell line knockdown assays, comparison with YAP overexpression Molecular cancer research : MCR Medium 35046109
2023 MOB4 KO MCF10A cells display increased collective cell migration with loss of migration orientation in a wound healing assay. Upon wound healing, MOB4 relocalizes to the front edge of leader and follower cells migrating toward the wound. The role of MOB4 in controlling collective migration requires YAP1: MOB4 KO cells fail to activate YAP1, and the phenotype is rescued by constitutively active YAP1. CRISPR/Cas9 knockout, wound healing assay, live imaging/relocalization, genetic rescue with constitutively active YAP1 Advanced science (Weinheim, Baden-Wurttemberg, Germany) Medium 41276909
2025 Striatin-3 and MOB4 were identified as novel Rac1 interactors in Schwann cells by co-immunoprecipitation. Schwann-cell-specific ablation of striatin-3 causes defects in lamellipodia formation; conditional knockout of striatins causes a severe delay in radial sorting. Deletion of Rac1 or striatin-1/3 in Schwann cells causes defects in YAP/TAZ activation and expression of YAP/TAZ co-regulated genes (extracellular matrix receptors), placing MOB4/STRIPAK downstream of Rac1 in Hippo pathway regulation during peripheral nervous system development. Co-immunoprecipitation (Rac1-striatin-3/MOB4 interaction), conditional Schwann cell knockout (Cre-lox), lamellipodia/radial sorting phenotyping, YAP/TAZ phosphorylation assays Cell reports Medium 40056414
2023 Proximity-dependent biotin identification (BioID) mapped the interactome of all seven human MOB proteins including MOB4. MOB4's proximity network was defined; the dataset confirmed known STRIPAK complex interactions for MOB4 and distinguished MOB4's interactome from those of other MOB family members. MOB3C (not MOB4) uniquely interacted with 7 of 10 subunits of the RNase P complex. BioID proximity labeling in HeLa and HEK293 cells, affinity purification-mass spectrometry validation, pre-tRNA cleavage assay The Journal of biological chemistry Medium 37536630
2023 Drosophila Mob4 is required for male fertility but has no detectable role in female fertility. mob4 RNAi leads to defective spermatid individualization, absence of mature sperm in seminal vesicles, expansion of outer axonemal microtubule doublets (loss of 9+2 linkage), and defective mitochondrial organization. Depletion of STRIPAK components Strip and Cka similarly impairs male fertility. Human MOB4 transgene rescues all Drosophila mob4 RNAi phenotypes, confirming evolutionary conservation. RNAi knockdown, transmission electron microscopy, genetic rescue with human MOB4 transgene, parallel depletion of other STRIPAK components Genetics Medium 37259670
2013 In Neurospora crassa, phosphorylation of MOB-3 (MOB4 ortholog) by the MAP kinase MAK-2 impacts the nuclear accumulation of the cell wall integrity MAP kinase MAK-1. The STRIPAK complex (containing MOB-3/HAM-2/HAM-3/HAM-4/PPG-1/PP2A-A) is assembled at the nuclear envelope and is required for MAK-1 nuclear accumulation. MAK-2-dependent phosphorylation of the N-terminus of MOB-3 is required for proper fruiting body morphology. Genetic/biochemical analysis, live cell imaging, phosphorylation analysis, nuclear accumulation assays Molecular microbiology Medium 24028079

Source papers

Stage 0 corpus · 42 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Molecular & cellular proteomics : MCP 303 18782753
2013 STRIPAK complexes: structure, biological function, and involvement in human diseases. The international journal of biochemistry & cell biology 185 24333164
2011 Identification and characterization of genes required for cell-to-cell fusion in Neurospora crassa. Eukaryotic cell 126 21666072
2011 Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3. BMC biochemistry 89 21985334
2013 HAM-2 and HAM-3 are central for the assembly of the Neurospora STRIPAK complex at the nuclear envelope and regulate nuclear accumulation of the MAP kinase MAK-1 in a MAK-2-dependent manner. Molecular microbiology 66 24028079
2018 The MST4-MOB4 complex disrupts the MST1-MOB1 complex in the Hippo-YAP pathway and plays a pro-oncogenic role in pancreatic cancer. The Journal of biological chemistry 59 30072378
1996 Sensitivity to dietary obesity linked to a locus on chromosome 15 in a CAST/Ei x C57BL/6J F2 intercross. Mammalian genome : official journal of the International Mammalian Genome Society 54 8703121
2011 The phocein homologue SmMOB3 is essential for vegetative cell fusion and sexual development in the filamentous ascomycete Sordaria macrospora. Current genetics 52 21229248
2009 Two NDR kinase-MOB complexes function as distinct modules during septum formation and tip extension in Neurospora crassa. Molecular microbiology 50 19788544
2021 Cryo-EM structure of the Hippo signaling integrator human STRIPAK. Nature structural & molecular biology 48 33633399
2015 The composition and function of the striatin-interacting phosphatases and kinases (STRIPAK) complex in fungi. Fungal genetics and biology : FG & B 48 26439752
2019 STRIPAK Members Orchestrate Hippo and Insulin Receptor Signaling to Promote Neural Stem Cell Reactivation. Cell reports 45 31167138
2016 Identification of Novel Reference Genes Suitable for qRT-PCR Normalization with Respect to the Zebrafish Developmental Stage. PloS one 43 26891128
2019 Assembly of a heptameric STRIPAK complex is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans. PLoS genetics 36 30883543
2010 DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization. The Journal of neuroscience : the official journal of the Society for Neuroscience 30 20392941
2008 Mob4 plays a role in spindle focusing in Drosophila S2 cells. Journal of cell science 25 18388316
2020 STRIPAK Limits Stem Cell Differentiation of a WNT Signaling Center to Control Planarian Axis Scaling. Current biology : CB 24 31928872
2024 The Cryptococcus neoformans STRIPAK complex controls genome stability, sexual development, and virulence. PLoS pathogens 22 39561188
1999 Genetics of abdominal visceral fat levels. American journal of human biology : the official journal of the Human Biology Council 22 11533946
2018 Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons. The Journal of biological chemistry 19 29802198
1979 A complementation analysis of mobilization deficient mutants of the plasmid ColE1. Molecular & general genetics : MGG 19 225640
2017 ChMob2 binds to ChCbk1 and promotes virulence and conidiation of the fungal pathogen Colletotrichum higginsianum. BMC microbiology 18 28103800
2016 An Epichloë festucae homologue of MOB3, a component of the STRIPAK complex, is required for the establishment of a mutualistic symbiotic interaction with Lolium perenne. Molecular plant pathology 18 27277141
2023 The STRIPAK complex orchestrates cell wall integrity signalling to govern the fungal development and virulence of Fusarium graminearum. Molecular plant pathology 14 37278525
1977 Chromosomal characteristics of six cultured lymphoblastoid cell lines originating from Marek's disease lymphomas. Biken journal 11 69431
2022 MOB3A Bypasses BRAF and RAS Oncogene-Induced Senescence by Engaging the Hippo Pathway. Molecular cancer research : MCR 9 35046109
2022 Mob4-dependent STRIPAK involves the chaperonin TRiC to coordinate myofibril and microtubule network growth. PLoS genetics 7 35737712
2023 Mob4 is essential for spermatogenesis in Drosophila melanogaster. Genetics 6 37259670
2023 Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex. The Journal of biological chemistry 5 37536630
2023 A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway. eLife 4 37665675
2022 STRIPAK regulation of katanin microtubule severing in the Caenorhabditis elegans embryo. Genetics 4 35298637
2022 Pan-Cancer Analysis on the Oncogenic Role of Programmed Cell Death 10. Journal of oncology 3 36276268
2025 The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells. Cell reports 2 40056414
2023 Mob4 is required for neurodevelopment in zebrafish. microPublication biology 2 36915897
2023 FARL-11 (STRIP1/2) is required for sarcomere and sarcoplasmic reticulum organization in C. elegans. Molecular biology of the cell 2 37314837
2025 Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 1 41276909
2024 The Cryptococcus neoformans STRIPAK complex controls genome stability, sexual development, and virulence. bioRxiv : the preprint server for biology 1 39149236
2021 Loss of Caenorhabditis elegans homologue of human MOB4 compromises life span, health life span and thermotolerance. Genes to cells : devoted to molecular & cellular mechanisms 1 34428327
2026 Systems-level phosphoproteomics reveals conserved and subunit-specific STRIPAK signaling networks in Cryptococcus neoformans. bioRxiv : the preprint server for biology 0 41584308
2024 The STRIPAK complex is required for radial sorting and laminin receptor expression in Schwann cells. bioRxiv : the preprint server for biology 0 39554194
2023 FARL-11 (STRIP1/2) is Required for Sarcomere and Sarcoplasmic Reticulum Organization in C. elegans. bioRxiv : the preprint server for biology 0 36945551
1986 Differential scanning calorimetric and theoretical studies of ColE1 DNA. Nucleic acids symposium series 0 3550711

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