Affinage

SGO1

Shugoshin 1 · UniProt Q5FBB7

Length
561 aa
Mass
64.2 kDa
Annotated
2026-04-28
56 papers in source corpus 27 papers cited in narrative 27 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SGO1 is a centromeric adaptor protein that protects sister chromatid cohesion during cell division and recruits key mitotic regulators to ensure accurate chromosome segregation. SGO1 is targeted to centromeres through direct binding to CENP-A and recognition of the Bub1-phosphorylated H2A-T120 mark; CDK-mediated phosphorylation of SGO1 activates its direct binding to cohesin, whereupon the SGO1-PP2A complex dephosphorylates sororin to exclude WAPL and shield centromeric cohesin from prophase removal (PMID:23242214, PMID:26190260, PMID:37777834). SGO1 also recruits the chromosomal passenger complex (CPC) to centromeres through its histone H3-like N-terminal tail binding Survivin and its coiled-coil domain binding Borealin, while SET antagonizes SGO1-cohesin interaction to permit timely anaphase onset, and APC/C-Cdh1 degrades SGO1 after mitosis via KEN box and D box motifs (PMID:35776132, PMID:32697622, PMID:31227592, PMID:19015261). A homozygous K23E mutation in SGOL1 causes Chronic Atrial and Intestinal Dysrhythmia (CAID syndrome), with patient cells exhibiting centromeric cohesion defects and enhanced TGF-β signaling (PMID:25282101).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2005 High

    The foundational question of what Sgo1 does during chromosome segregation was answered: Sgo1 functions as a tension-sensing component of the spindle checkpoint in budding yeast and protects pericentromeric cohesin in a domain established by Bub1, the core centromere, and kinetochore proteins.

    Evidence Genetic epistasis, spindle checkpoint assays, ChIP mapping of Sgo1-cohesin domains in budding yeast

    PMID:15637284 PMID:16357219

    Open questions at the time
    • Mechanism of Sgo1-mediated cohesin protection unknown
    • Human ortholog function not yet demonstrated
    • How Bub1 recruits Sgo1 molecularly was undefined
  2. 2006 High

    The molecular basis of Sgo1 cohesion protection was established: SGO1 directly binds PP2A, and this complex is required for centromeric localization and counteracts Plk1-mediated cohesin removal. Two human isoforms with distinct subcellular localizations were identified.

    Evidence Co-immunoprecipitation, RNAi rescue, GFP-fusion localization in human cells

    PMID:16580887 PMID:16582621

    Open questions at the time
    • How PP2A enzymatic activity protects cohesin was unknown
    • Substrate of SGO1-PP2A at centromeres not identified
    • Functional significance of the short isoform unclear
  3. 2007 High

    Phospho-regulation of SGO1 by NEK2A and Bub1 kinase was established: NEK2A directly phosphorylates SGO1 at Ser14/Ser507 to regulate kinetochore distribution and chromosome congression, while Bub1 kinase activity is required for Sgo1 centromeric localization and biorientation.

    Evidence In vitro kinase assays, phospho-mutant expression, genetic epistasis in human cells and budding yeast

    PMID:17621308 PMID:18081426

    Open questions at the time
    • Whether NEK2A and Bub1 regulate Sgo1 through the same or parallel pathways was unclear
    • Direct chromatin mark read by Sgo1 not yet identified
  4. 2008 High

    The short splice variant sSgo1 was shown to have a distinct centrosomal/centriole cohesion function dependent on Plk1, expanding SGO1 biology beyond chromosome cohesion. Separately, SGO1 degradation at mitotic exit was shown to require APC/C-Cdh1 acting on KEN box and D box motifs.

    Evidence RNAi, GFP localization, Co-IP for sSgo1-Plk1; in vitro ubiquitination and degron mutagenesis for degradation

    PMID:18331714 PMID:19015261

    Open questions at the time
    • Centriole cohesion substrates of sSgo1 not identified
    • Whether non-degradable SGO1 causes long-term cellular consequences was untested
  5. 2010 High

    The temporal sequence of SGO1 centromere recruitment was resolved: SGO1 first associates with centromeric heterochromatin in G2 via HP1, establishing cohesion protection before mitotic entry, then is re-recruited in prophase by Bub1, although HP1-SGO1 interaction proved dispensable for cohesion protection per se.

    Evidence Live-cell imaging in Bub1-null MEFs with complementation; HP1-binding-deficient Sgo1 mutant functional analysis

    PMID:20124418 PMID:21346195

    Open questions at the time
    • What G2-specific SGO1 does mechanistically to 'establish' protection was undefined
    • How SGO1 transitions between HP1-dependent and Bub1-dependent binding modes was unclear
  6. 2012 High

    The core biochemical mechanism of cohesion protection was elucidated: CDK phosphorylation activates SGO1 direct binding to cohesin, and the resulting SGO1-PP2A complex dephosphorylates sororin on PDS5, thereby excluding WAPL from the cohesin complex. In yeast, Bub1-H2A phosphorylation and Sgo1 were shown to regulate pericentric chromatin geometry.

    Evidence In vitro binding assays, phospho-mutant rescue, Co-IP of cohesin sub-complexes in human cells; live imaging and FRAP in budding yeast

    PMID:22365852 PMID:23242214

    Open questions at the time
    • Structural basis of phospho-SGO1/cohesin interaction unknown
    • Whether CDK acts directly on SGO1 in vivo required further confirmation
  7. 2013 High

    Two functionally distinct pools of SGO1-PP2A were identified: a cohesin-dependent inner centromere pool and an H2A-pT120-dependent kinetochore pool, with tension-dependent redistribution between them controlling chromosome segregation fidelity.

    Evidence Phospho-specific antibodies, RNAi, tension manipulation in human cells

    PMID:24055156

    Open questions at the time
    • Phosphatase responsible for tension-dependent SGO1 dephosphorylation unknown
    • How the two pools coordinate their functions during biorientation unclear
  8. 2014 High

    Multiple additional functions of Sgo1 were uncovered: Sgo1-PP2A recruits condensin to pericentric chromatin and maintains Aurora B/Ipl1 at kinetochores in yeast; artificial PP2A tethering recapitulates Sgo1 function on individual chromosomes; and Aurora B phosphorylates SGO1 to regulate its centromere-arm distribution. A homozygous K23E mutation in SGOL1 was identified as the cause of CAID syndrome.

    Evidence ChIP and genetic epistasis in yeast; artificial tethering; in vitro kinase assay in human cells; human genetics with patient fibroblast and zebrafish validation

    PMID:24945276 PMID:25236599 PMID:25282101 PMID:25451264

    Open questions at the time
    • How K23E mechanistically disrupts SGO1 function in cardiac and intestinal tissues unknown
    • Whether condensin recruitment by SGO1 is conserved in vertebrates untested
  9. 2015 High

    SGO1 was established as a direct reader of H2A-pT120, and a Bub1-driven RNA Polymerase II transcription mechanism at kinetochores was shown to facilitate SGO1 transit from kinetochores to centromeric cohesin.

    Evidence In vitro binding assays, Co-IP of SGO1-Pol II, Pol II inactivation during mitosis in human cells

    PMID:26190260

    Open questions at the time
    • Nature and function of SGO1-RNA interaction not characterized
    • Whether Pol II transcription at kinetochores is universally required for cohesion protection unclear
  10. 2018 High

    CENP-A was identified as a direct binding partner that anchors Sgo1 specifically to centromeric chromatin, with the N-terminal coiled-coil of Sgo1 sufficient for this interaction.

    Evidence In vivo Co-IP, in vitro binding, domain mapping, ChIP in budding yeast

    PMID:28980861

    Open questions at the time
    • Whether CENP-A and H2A-pT120 recruit Sgo1 through the same or separate binding events was unclear
    • Structural basis of Sgo1-CENP-A interaction unknown
  11. 2019 High

    The mechanism for timely release of cohesin protection was identified: SET directly binds SGO1 adjacent to its cohesin-binding motif and dose-dependently disrupts SGO1-cohesin interaction, promoting chromosome segregation without abolishing cohesion protection.

    Evidence In vitro dose-response binding, Co-IP, separation-of-function SGO1 mutants in human cells

    PMID:31227592

    Open questions at the time
    • How SET activity is temporally regulated relative to anaphase onset unknown
    • Whether SET acts on both SGO1 pools (inner centromere and kinetochore) untested
  12. 2022 High

    The molecular basis for CPC recruitment by SGO1 was resolved: the SGO1 N-terminal histone H3-like tail binds the Survivin BIR domain using the same surface as H3T3ph, while the coiled-coil domain binds Borealin, enabling simultaneous CPC and PP2A binding to SGO1.

    Evidence Structure-function analysis, mutagenesis, biochemical reconstitution in Xenopus extracts and human cells

    PMID:32697622 PMID:35776132

    Open questions at the time
    • Full structural model of the SGO1-CPC-PP2A ternary complex lacking
    • How H3T3ph and SGO1 compete or cooperate for CPC binding in vivo not fully resolved
  13. 2024 Medium

    Conservation of the CENP-A-SGO1 interaction was extended to human cells, with basic residues in the SGO1 C-terminal domain identified as critical for CENP-A binding and for proper centromeric localization of both SGO1 and Aurora B.

    Evidence Co-IP, domain mapping, mutational analysis, localization studies in human cells

    PMID:37777834

    Open questions at the time
    • Whether CENP-A binding and H2A-pT120 reading are sequential or parallel recruitment mechanisms remains unresolved
    • Structural basis of human CENP-A-SGO1 interaction unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key open questions include: the structural basis of the multi-valent SGO1 platform integrating cohesin, PP2A, CPC, CENP-A, and H2A-pT120 interactions; how SGO1 dysfunction in non-dividing tissues leads to CAID syndrome cardiac and intestinal pathology; and whether the Pol II-dependent transit mechanism and SET-mediated release are coordinated in vivo to achieve the precise timing of cohesion resolution.
  • No high-resolution structure of full-length SGO1 with its partners
  • Tissue-specific functions of SGO1 in post-mitotic cells mechanistically undefined
  • In vivo coordination of SGO1 recruitment and release pathways not fully resolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0060090 molecular adaptor activity 4 GO:0042393 histone binding 3
Localization
GO:0005694 chromosome 6 GO:0005815 microtubule organizing center 1
Pathway
R-HSA-1640170 Cell Cycle 6 R-HSA-1643685 Disease 1
Partners
BIRC5BUB1CDCA8CENP-ANEK2APLK1PP2ASET
Complex memberships
Chromosomal Passenger Complex (CPC)SGO1-PP2A

Evidence

Reading pass · 27 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2006 Human SGO1 directly binds to protein phosphatase 2A (PP2A), and this interaction is required for centromeric localization of SGO1. Bub1 targets PP2A to centromeres in a Bub1-dependent manner, and PP2A at centromeres counteracts Plk1-mediated removal of SGO1 from centromeres. Co-immunoprecipitation, RNAi knockdown, localization rescue experiments Developmental cell High 16580887
2005 Budding yeast Sgo1 is required for sensing lack of tension at the kinetochore during mitosis (spindle checkpoint tension-sensing component), but not for responding to microtubule depolymerization; Sgo1 degradation upon sister chromatid separation prevents cell cycle arrest in anaphase. Genetic analysis, spindle checkpoint assays, chromosome segregation assays in budding yeast Science (New York, N.Y.) High 15637284
2012 CDK-mediated, mitosis-specific phosphorylation of human SGO1 activates its cohesion-protection function and enables direct binding to cohesin. Phospho-SGO1-bound cohesin contains PP2A, PDS5, and hypophosphorylated sororin but lacks WAPL. SGO1-PP2A dephosphorylates PDS5-bound sororin, protecting centromeric cohesin from WAPL-mediated removal. In vitro binding assays, phosphorylation-deficient mutants, Co-IP, RNAi rescue experiments Nature cell biology High 23242214
2008 A major splice variant of SGO1, sSgo1, localizes to centrosomes in interphase and spindle poles in mitosis (distinct from full-length Sgo1 at kinetochores). sSgo1 interacts with Plk1 and its spindle pole localization is Plk1-dependent. sSgo1 is required for centriole cohesion, preventing premature centriole separation. RNAi, GFP localization, Co-immunoprecipitation, dominant-negative expression Developmental cell High 18331714
2009 In Xenopus egg extracts, Sgo1 plays a role in stabilizing cohesin along chromosome arms, which is antagonized by the mitotic kinases Plk1 and Aurora B; Wapl and Pds5 directly modulate cohesin conformational changes for dissociation during prophase. In vitro Xenopus egg extract system, immunodepletion, add-back experiments Genes & development High 19696148
2005 In budding yeast meiosis, Sgo1 localizes to cohesin-associated regions at the centromere and the 50-kb surrounding region, establishing a cohesin-protected domain. This domain requires the 120-bp core centromere, Bub1, and the meiosis-specific factor Spo13. Cohesins and kinetochore proteins Iml3 and Chl4 are necessary for Sgo1 association with pericentric regions. ChIP, genetic epistasis, meiotic chromosome analysis in budding yeast Genes & development High 16357219
2013 In human cells, cohesin and H2A-pT120 specify two distinct pools of Sgo1-PP2A: one at inner centromeres (cohesin-dependent) and one at kinetochores (H2A-pT120-dependent). Kinetochore tension triggers Sgo1 dephosphorylation and redistribution from inner centromeres to kinetochores; incomplete redistribution causes chromosome nondisjunction. Localization studies, phospho-specific antibodies, RNAi, tension manipulation Current biology : CB High 24055156
2015 Human SGO1 is a direct reader of the Bub1-mediated H2A-pT120 mark at kinetochores. Bub1 also recruits RNA Polymerase II to unattached kinetochores, promoting active transcription that enables kinetochore-bound Sgo1 (recruited by H2A-pT120) to reach cohesin embedded in centromeric chromatin. Sgo1 interacts with Pol II in human cells and with RNA in vitro. In vitro binding assays, Co-IP, live imaging, Pol II inactivation in mitosis Molecular cell High 26190260
2007 NEK2A directly binds human Sgo1 in vitro and co-localizes with Sgo1 at the kinetochore. NEK2A phosphorylates Sgo1 at Ser14 and Ser507, and expression of non-phosphorylatable Sgo1 mutants causes chromosome congression defects including syntelic and monotelic attachments. In vitro kinase assay, 32P incorporation, Co-IP, expression of phosphorylation-deficient mutants Cell research High 17621308
2007 In budding yeast, Bub1 kinase domain is required for proper localization of Sgo1 to centromeres, and both Bub1 kinase activity and Sgo1 are required for accurate chromosome biorientation after nocodazole treatment. Genetic analysis, localization studies, chromosome segregation assays in budding yeast PLoS genetics High 18081426
2008 Human Sgo1 is degraded during mitotic exit via the APC/C-Cdh1 pathway. Sgo1 contains two functional degradation motifs (KEN box and D box); deletion of both is required to stabilize the protein. Bub1 contributes to Sgo1 steady-state protein levels through an APC/C-independent mechanism. Non-degradable Sgo1 does not impair mitotic progression. In vitro ubiquitination assay, mutagenesis of degrons, overexpression of Cdh1, cell cycle analysis The Journal of biological chemistry High 19015261
2011 In human cells, HP1α is recruited to mitotic centromeres by INCENP (CPC subunit), not by Sgo1. Both HP1-INCENP and HP1-Sgo1 interactions require the HP1 chromo shadow domain binding to PXVXL/I motifs. A Sgo1 mutant deficient in HP1 binding is functional in centromeric cohesion protection and localizes normally to centromeres in mitosis, demonstrating that HP1-Sgo1 interaction is dispensable for cohesion protection. Biochemical pull-down, structural analysis, functional complementation with HP1-binding deficient mutants Molecular biology of the cell High 21346195
2010 Human Sgo1 is first recruited to centromeric heterochromatin in G2 in an HP1-dependent manner, then becomes diffusely localized in early prophase, before returning to centromeres in prophase via Bub1 kinase activity. Centromeric cohesion is maintained even when Bub1 kinase is absent and Sgo1 is absent from mitotic centromeres, because Sgo1 establishes protection in G2. Live-cell imaging, Bub1 kinase-dead complementation in Bub1-null MEFs, cell cycle-staged localization Journal of cell science High 20124418
2014 In budding yeast, Sgo1 together with PP2A-Rts1 ensures localization of condensin to centromeric chromatin; failure to recruit condensin results in abnormal pericentric chromatin conformation. Sgo1 is also required for maintaining Aurora B/Ipl1 localization on kinetochores during metaphase, suggesting a dual role in promoting biorientation. Genetic epistasis, ChIP, localization studies in budding yeast PLoS genetics High 24945276
2011 In budding yeast, Sgo1 overexpression partially rescues chromosome segregation defects of bub1Δ cells. Sgo1 is identified as a possible partner of Mps1; Mps1 is required for Sgo1 localization to kinetochores, and Sgo1 overexpression rescues metaphase Mps1 inactivation defects. Bub1, Sgo1, and Mps1 facilitate chromosome biorientation independently of the Aurora B pathway. High-copy suppressor screen, genetic epistasis, localization studies in budding yeast Molecular biology of the cell Medium 21389114
2012 In budding yeast, Bub1 and Sgo1 regulate pericentric chromatin geometry and dynamics in response to altered microtubule dynamics; Bub1-mediated H2A phosphorylation and Sgo1 recruitment soften the chromatin spring, causing radial expansion of pericentric chromatin and cohesin ring. Live imaging, FRAP, genetic analysis in budding yeast Current biology : CB Medium 22365852
2014 In budding yeast, Sgo1 recruits the Rts1 isoform of PP2A to pericentromeric chromatin, and artificial recruitment of Rts1 to a single chromosome is sufficient to perform Sgo1 function on that chromosome. Sgo1 removal from chromosomes before anaphase depends on tension between sister chromatids, not on APC/C-mediated degradation. Sgo1 is an APC/C substrate in budding yeast with an unusual D-box-related sequence motif. Genetic epistasis, artificial tethering experiments, APC/C degradation assays in budding yeast Journal of cell science High 25236599
2016 In budding yeast, the Bub1-H2A-Sgo1-PP2A-Rts1 axis prevents premature spindle assembly checkpoint silencing prior to tension generation; Sgo1 mutants with abolished binding to H2A or PP2A-Rts1 show premature SAC silencing, establishing this pathway in tension-sensitive checkpoint maintenance. Genetic epistasis, checkpoint duration assays, separation-of-function Sgo1 mutants in budding yeast Genetics Medium 28040741
2016 In Xenopus egg extract system, Bub1 targeting to centromeres (via CENP-C and CENP-T independently through the KMN network) is sufficient for Sgo1 recruitment in the absence of other kinetochore components. Mps1 is required for this Bub1-dependent Sgo1 recruitment pathway even in the absence of checkpoint signaling. Xenopus cell-free system, forced targeting experiments, immunodepletion Chromosoma High 27116032
2018 In budding yeast, CENP-A (Cse4) interacts with Sgo1 in vivo and in vitro. The N-terminal coiled-coil domain of Sgo1 is sufficient for CENP-A interaction and for association with centromeric (but not pericentromeric) chromatin. Depletion of CENP-A results in loss of Sgo1 from centromeric chromatin. Co-IP in vivo, in vitro binding assay, domain mapping, ChIP, chromosome segregation assays Cell cycle (Georgetown, Tex.) High 28980861
2020 In Xenopus egg extracts and biochemical reconstitution, Sgo1 directly interacts with the dimerization domain of Borealin (CPC subunit). Borealin and PP2A can bind simultaneously to the coiled-coil domain of Sgo1. A Borealin mutant disrupting the Sgo1-Borealin interaction causes defects in CPC chromosomal recruitment and Aurora B-dependent spindle assembly but not spindle assembly checkpoint signaling at unattached kinetochores. Biochemical reconstitution, in vitro binding assays, Xenopus egg extracts, separation-of-function mutants Molecular biology of the cell High 32697622
2022 Using an integrative structure-function approach, the Sgo1 N-terminal 'histone H3-like' tail interacts with the Survivin BIR domain as a hotspot for CPC-Sgo1 assembly; downstream Sgo1 residues and Borealin contribute to high-affinity binding. Sgo1 and H3T3ph use the same surface on Survivin to bind CPC, suggesting spatiotemporally restricted interactions. Disrupting Sgo1-Survivin interaction perturbs CPC centromere localization and function. Structure-function analysis, mutagenesis, biochemical binding assays, functional validation The Journal of cell biology High 35776132
2014 Aurora B kinase interacts with and phosphorylates Sgo1 in vitro and in vivo. Aurora B-mediated phosphorylation of Sgo1 regulates the distribution of Sgo1 between centromeres and chromosome arms; expression of Aurora B kinase-dead mutants of Sgo1 causes mislocalization from centromeres to chromosome arms. Co-IP, in vitro kinase assay, expression of kinase-dead mutants, localization analysis Biochemical and biophysical research communications Medium 25451264
2019 SET, a known PP2A inhibitor, directly binds a domain in Sgo1 adjacent to the cohesin-binding motif and disrupts Sgo1-cohesin binding in a dose-dependent manner in vitro and in cells. SET-binding-deficient Sgo1 mutant fully supports centromeric cohesion protection but delays chromosome segregation, indicating SET promotes timely chromosome segregation by disrupting Sgo1-cohesin interaction. In vitro binding assay, Co-IP, dose-response experiments, separation-of-function Sgo1 mutants The Journal of cell biology High 31227592
2024 Human CENP-A directly interacts with Sgo1 and determines Sgo1 localization to centromeres during mitosis. Lysine and arginine residues in the C-terminal domain of Sgo1 are critical for CENP-A binding. Mutation of these basic residues perturbs localization of both Sgo1 and Aurora B to centromeres, resulting in aberrant chromosome segregation and premature chromatid separation. Co-IP, biochemical domain mapping, mutational analysis, localization studies Journal of molecular cell biology Medium 37777834
2014 Homozygous founder mutation in SGOL1 (K23E) causes CAID syndrome (Chronic Atrial and Intestinal Dysrhythmia). Patient fibroblasts show accelerated cell cycle progression, higher senescence rate, enhanced TGF-β signaling activation, and karyotypes displaying centromeric cohesion defects (railroad appearance). Morpholino knockdown of sgol1 in zebrafish recapitulates the human abnormalities. Human genetics, patient fibroblast analysis, zebrafish morpholino knockdown Nature genetics High 25282101
2006 Two major isoforms of human Sgo1 have entirely different subcellular localization patterns: the long isoform localizes to kinetochores during G2 and mitosis, while the short isoform (sSgo1, lacking exon 6) localizes to mitotic spindles and does not associate with kinetochores at any stage. GFP fusion localization, cell cycle staging Cell cycle (Georgetown, Tex.) Medium 16582621

Source papers

Stage 0 corpus · 56 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2006 PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Developmental cell 283 16580887
2009 Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl-Pds5 and Sgo1. Genes & development 174 19696148
2012 Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis. Nature cell biology 162 23242214
2005 The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes. Science (New York, N.Y.) 154 15637284
2015 Mitotic Transcription Installs Sgo1 at Centromeres to Coordinate Chromosome Segregation. Molecular cell 148 26190260
2013 Phospho-H2A and cohesin specify distinct tension-regulated Sgo1 pools at kinetochores and inner centromeres. Current biology : CB 124 24055156
2008 sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1. Developmental cell 106 18331714
2007 Bub1 kinase targets Sgo1 to ensure efficient chromosome biorientation in budding yeast mitosis. PLoS genetics 97 18081426
2014 Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm. Nature genetics 94 25282101
2011 Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells. Molecular biology of the cell 79 21346195
2005 The core centromere and Sgo1 establish a 50-kb cohesin-protected domain around centromeres during meiosis I. Genes & development 79 16357219
2008 Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer. Gut 66 18635744
2012 Haploinsufficiency of SGO1 results in deregulated centrosome dynamics, enhanced chromosomal instability and colon tumorigenesis. Cell cycle (Georgetown, Tex.) 58 22262168
2014 Sgo1 regulates both condensin and Ipl1/Aurora B to promote chromosome biorientation. PLoS genetics 56 24945276
2007 Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis. Cell research 46 17621308
2012 Bub1 kinase and Sgo1 modulate pericentric chromatin in response to altered microtubule dynamics. Current biology : CB 44 22365852
2018 Genome-wide CRISPR screen reveals SGOL1 as a druggable target of sorafenib-treated hepatocellular carcinoma. Laboratory investigation; a journal of technical methods and pathology 40 29467456
2008 Multiple anaphase-promoting complex/cyclosome degrons mediate the degradation of human Sgo1. The Journal of biological chemistry 40 19015261
2011 Bub1, Sgo1, and Mps1 mediate a distinct pathway for chromosome biorientation in budding yeast. Molecular biology of the cell 39 21389114
2010 Sgo1 establishes the centromeric cohesion protection mechanism in G2 before subsequent Bub1-dependent recruitment in mitosis. Journal of cell science 37 20124418
2006 Differential subcellular localizations of two human Sgo1 isoforms: implications in regulation of sister chromatid cohesion and microtubule dynamics. Cell cycle (Georgetown, Tex.) 32 16582621
2014 Sgo1 recruits PP2A to chromosomes to ensure sister chromatid bi-orientation during mitosis. Journal of cell science 31 25236599
2013 SGO1 but not SGO2 is required for maintenance of centromere cohesion in Arabidopsis thaliana meiosis. Plant reproduction 30 23884434
2011 A novel tumor-derived SGOL1 variant causes abnormal mitosis and unstable chromatid cohesion. Oncogene 30 21532624
2015 Sgo1 is a potential therapeutic target for hepatocellular carcinoma. Oncotarget 28 25638162
2013 Frameshift mutations of chromosome cohesion-related genes SGOL1 and PDS5B in gastric and colorectal cancers with high microsatellite instability. Human pathology 26 23850494
2013 SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers. Scientific reports 24 24146025
2011 Sgo1 is required for co-segregation of sister chromatids during achiasmate meiosis I. Cell cycle (Georgetown, Tex.) 23 21330786
2016 Systemic Chromosome Instability Resulted in Colonic Transcriptomic Changes in Metabolic, Proliferation, and Stem Cell Regulators in Sgo1-/+ Mice. Cancer research 20 26833665
2015 Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice. Carcinogenesis 20 25740822
2017 The E2F activators control multiple mitotic regulators and maintain genomic integrity through Sgo1 and BubR1. Oncotarget 19 29100415
2021 Long noncoding RNA SGO1-AS1 inactivates TGFβ signaling by facilitating TGFB1/2 mRNA decay and inhibits gastric carcinoma metastasis. Journal of experimental & clinical cancer research : CR 18 34706749
2022 Mechanistic basis for Sgo1-mediated centromere localization and function of the CPC. The Journal of cell biology 17 35776132
2019 SGO1 induces proliferation and metastasis of prostate cancer through AKT-mediated signaling pathway. American journal of cancer research 16 31911855
2018 Budding yeast CENP-ACse4 interacts with the N-terminus of Sgo1 and regulates its association with centromeric chromatin. Cell cycle (Georgetown, Tex.) 16 28980861
2016 SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells. Scientific reports 16 27539729
2006 Human Sgo1 is an excellent target for induction of apoptosis of transformed cells. Cell cycle (Georgetown, Tex.) 16 16628005
2020 The Borealin dimerization domain interacts with Sgo1 to drive Aurora B-mediated spindle assembly. Molecular biology of the cell 15 32697622
2011 Lentivirus-mediated siRNA interference targeting SGO-1 inhibits human NSCLC cell growth. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 15 22161216
2016 Bub1 targeting to centromeres is sufficient for Sgo1 recruitment in the absence of kinetochores. Chromosoma 13 27116032
2016 Premature Silencing of the Spindle Assembly Checkpoint Is Prevented by the Bub1-H2A-Sgo1-PP2A Axis in Saccharomyces cerevisiae. Genetics 13 28040741
2018 Molecular Signature of CAID Syndrome: Noncanonical Roles of SGO1 in Regulation of TGF-β Signaling and Epigenomics. Cellular and molecular gastroenterology and hepatology 12 30739867
2014 Regulation of the subcellular shuttling of Sgo1 between centromeres and chromosome arms by Aurora B-mediated phosphorylation. Biochemical and biophysical research communications 10 25451264
2019 Assessment of SGO1 and SGO1-AS1 contribution in breast cancer. Human antibodies 9 31156154
2019 SET binding to Sgo1 inhibits Sgo1-cohesin interactions and promotes chromosome segregation. The Journal of cell biology 8 31227592
2017 Characterization of Sgo1 expression in developing and adult mouse. Gene expression patterns : GEP 8 28465207
2015 Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model. Molecular carcinogenesis 8 25773652
2013 SGO1 maintains bovine meiotic and mitotic centromeric cohesions of sister chromatids and directly affects embryo development. PloS one 7 24019931
2017 Dataset of Sgo1 expression in cardiac, gastrointestinal, hepatic and neuronal tissue in mouse. Data in brief 6 28748208
2022 The zebrafish cohesin protein Sgo1 is required for cardiac function and eye development. Developmental dynamics : an official publication of the American Association of Anatomists 5 35275424
2024 Sgo1 interacts with CENP-A to guide accurate chromosome segregation in mitosis. Journal of molecular cell biology 4 37777834
2022 SGOL1-AS1 enhances cell survival in acute myeloid leukemia by maintaining pro-inflammatory signaling. Heliyon 4 36387443
2016 Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence. Journal of hematology & oncology 4 26847209
2009 Suppression of genomic instabilities caused by chromosome mis-segregation: a perspective from studying BubR1 and Sgo1. Journal of the Formosan Medical Association = Taiwan yi zhi 3 20040454
2025 Chronic atrial and intestinal dysrythmia syndrome: A late-onset intestinal pseudo-obstruction and cardiac dysfunction due to an SGO1 mutation. JPGN reports 0 41245052
2020 Microsatellite frameshift variants in SGO1 of gastric cancer are not always associated with MSI status. Journal of clinical pathology 0 32817265