Affinage

SET

Protein SET · UniProt Q01105

Round 2 corrected
Length
290 aa
Mass
33.5 kDa
Annotated
2026-04-28
130 papers in source corpus 16 papers cited in narrative 16 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SET (also known as I2PP2A/TAF-Iβ) is a multifunctional nuclear oncoprotein that integrates phosphatase regulation, histone chaperone activity, and chromatin remodeling to control cell proliferation, transcription, and apoptosis. SET is a potent and specific inhibitor of protein phosphatase 2A (PP2A) at ~2 nM IC50, and this inhibition sustains oncogenic signaling in contexts such as BCR/ABL-driven leukemogenesis, where BCR/ABL induces SET expression to suppress PP2A tumor-suppressor activity (PMID:8626647, PMID:16286244). As the core subunit of the INHAT complex, SET masks histones from acetyltransferases p300/CBP and PCAF to repress transcription, and extends this activity to non-histone substrates including p53 and FoxO1, blocking p53-mediated apoptosis and cell-cycle arrest (PMID:11163245, PMID:21911363). SET additionally functions as a histone chaperone whose nucleosome-assembly activity is competitively inhibited by nuclear cytochrome c upon DNA damage, serves as the inhibitor of the NM23-H1 DNase within the Granzyme A apoptotic pathway, and regulates chromosome condensation upstream of condensin II through interaction with the MCPH1 BRCT domain (PMID:26216969, PMID:12628186, PMID:21515671).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1992 High

    Identification of SET as a proto-oncogene fused to CAN/NUP214 in acute undifferentiated leukemia established it as a gene of interest in hematopoietic malignancy and revealed its homology to yeast nucleosome assembly protein NAP-I.

    Evidence Genomic and cDNA cloning with chromosomal mapping from leukemia patient material

    PMID:1630450

    Open questions at the time
    • No biochemical activity assigned at this stage
    • Mechanism of oncogenicity of the SET-CAN fusion was unknown
  2. 1996 High

    Biochemical purification demonstrated that SET is a potent and specific endogenous inhibitor of PP2A (~2 nM IC50) with no activity against PP1, PP2B, or PP2C, establishing its first defined molecular function.

    Evidence Recombinant SET protein in phosphatase activity assays with specificity controls

    PMID:8626647

    Open questions at the time
    • Physiological contexts of PP2A inhibition were undefined
    • Structural basis of SET–PP2A interaction was unresolved
  3. 2001 High

    Discovery of SET/TAF-Iβ as a core subunit of the INHAT complex revealed a second major function: masking histones from acetyltransferases to repress transcription, linking SET to chromatin regulation independently of PP2A inhibition.

    Evidence Biochemical purification of endogenous complex, HAT inhibition assays, ChIP, and transcription reporter assays

    PMID:11163245

    Open questions at the time
    • Non-histone substrates of INHAT activity were not yet identified
    • Relative contribution of INHAT vs. PP2A inhibition to SET oncogenicity was unclear
  4. 2003 High

    SET was identified as the specific inhibitor of the NM23-H1 DNase within a Granzyme A-activated ER-associated complex, and Granzyme A cleavage of SET releases NM23-H1 to execute caspase-independent apoptotic DNA nicking, revealing a role in cytotoxic lymphocyte killing.

    Evidence Co-immunoprecipitation, GzmA cleavage assays, nuclear translocation imaging, CTL cytotoxicity assays

    PMID:12628186

    Open questions at the time
    • Structural details of SET–NM23-H1 interaction were not resolved
    • In vivo contribution to immune defense was not directly tested
  5. 2005 High

    BCR/ABL was shown to induce SET expression, thereby functionally inactivating PP2A to sustain leukemogenic signaling; reactivation of PP2A promoted BCR/ABL degradation and apoptosis, establishing SET–PP2A inhibition as essential for CML blast crisis.

    Evidence Gene expression analysis, phosphatase assays, siRNA and pharmacological PP2A activation, in vivo leukemogenesis model

    PMID:16286244

    Open questions at the time
    • Whether SET overexpression is sufficient for transformation without BCR/ABL was untested
    • Therapeutic targeting of SET in patients remained unexplored
  6. 2006 High

    SET was found to directly bind the M3 muscarinic receptor i3 loop and attenuate receptor-mediated calcium signaling, extending SET function beyond the nucleus to GPCR signaling regulation.

    Evidence GST pulldown from brain lysates, co-immunoprecipitation, siRNA knockdown with calcium mobilization readout

    PMID:17065150

    Open questions at the time
    • Whether SET modulates other GPCR subtypes was not assessed
    • Mechanism of SET's inhibitory effect on receptor signaling (PP2A-dependent vs. direct) was unresolved
  7. 2011 High

    Two studies extended SET's functional repertoire: SET/TAF-Iβ was shown to inhibit p53 acetylation via its INHAT domain, blocking p53-dependent apoptosis and cell-cycle arrest (validated in Drosophila), and SET was found to interact with MCPH1 to regulate chromosome condensation upstream of condensin II.

    Evidence Co-IP, HAT inhibition assays, Drosophila genetic rescue for p53; siRNA knockdown, epistasis with condensin II for MCPH1

    PMID:21515671 PMID:21911363

    Open questions at the time
    • Whether SET-MCPH1 interaction is regulated during the cell cycle was unknown
    • In vivo significance of SET–p53 axis in human tumors was not established
  8. 2014 Medium

    SET was shown to inhibit FoxO1 acetylation by p300 in an INHAT-domain-dependent manner and activate the FoxO1 target gene p21 under oxidative stress, broadening the repertoire of non-histone INHAT substrates.

    Evidence Co-immunoprecipitation, HAT inhibition assays, transcription reporter assays with oxidative stress

    PMID:24983498

    Open questions at the time
    • Single-lab finding; independent replication is lacking
    • Physiological relevance of SET–FoxO1 axis in vivo was not tested
  9. 2015 High

    NMR resolution of the cytochrome c–SET/TAF-Iβ complex revealed that nuclear cytochrome c, released specifically upon DNA damage, competitively locks SET's histone-binding domains, blocking nucleosome assembly — providing a structural mechanism coupling mitochondrial apoptotic signaling to chromatin remodeling.

    Evidence NMR spectroscopy, isothermal titration calorimetry, mutagenesis, nucleosome assembly assay

    PMID:26216969

    Open questions at the time
    • Whether cytochrome c binding to SET affects INHAT or PP2A inhibitory functions was not tested
    • In vivo validation of this regulatory mechanism in intact cells is limited

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structural basis of the SET–PP2A interaction, the relative contributions of SET's PP2A-inhibitory vs. INHAT vs. histone chaperone activities to its oncogenic function, and whether the diverse functions of SET are coordinately regulated or independently deployed in different cellular contexts.
  • No high-resolution structure of a SET–PP2A complex
  • No systematic separation-of-function studies across SET's distinct activities in a single system
  • Mechanism of SET regulation (post-translational modifications, turnover) is incompletely defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0140110 transcription regulator activity 3 GO:0042393 histone binding 2
Localization
GO:0005634 nucleus 6 GO:0005694 chromosome 1 GO:0005783 endoplasmic reticulum 1
Pathway
R-HSA-4839726 Chromatin organization 3 R-HSA-1643685 Disease 2 R-HSA-5357801 Programmed Cell Death 2 R-HSA-162582 Signal Transduction 1 R-HSA-1640170 Cell Cycle 1
Partners
CHRM3CYCSFOXO1MCPH1NME1PPP2CASETBP1TP53
Complex memberships
GzmA-activated SET complex (SET/NM23-H1/pp32/HMG-2/Ape1)INHAT complex

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1992 The SET gene was characterized as encoding a 32 kDa protein with homology to yeast nucleosome assembly protein NAP-I. SET was found fused to the CAN/NUP214 gene in acute undifferentiated leukemia, generating a SET-CAN fusion oncogene, establishing SET as a proto-oncogene at chromosome 9q34. Genomic and cDNA cloning, chromosomal mapping, sequence analysis Molecular and cellular biology High 1630450
1994 SET protein (PHAPII) was purified from the cytosolic fraction of human B-cells using an affinity matrix composed of the cytoplasmic region of the HLA-DR2 alpha chain, identifying it as a putative HLA class II associated protein with a highly acidic C-terminal region. Affinity chromatography, protein sequencing, cDNA sequencing Biological chemistry Hoppe-Seyler Medium 8192856
1996 SET (I2PP2A) was identified as a potent and specific inhibitor of protein phosphatase 2A (PP2A), with half-maximal inhibition at ~2 nM SET. SET did not inhibit PP1, PP2B, or PP2C, establishing its specificity for PP2A. Biochemical purification, phosphatase activity assays with recombinant human SET, N-terminal and internal amino acid sequencing The Journal of biological chemistry High 8626647
2001 SET/TAF-Iβ is a core subunit of the INHAT (inhibitor of acetyltransferases) complex, which potently inhibits histone acetyltransferase activity of p300/CBP and PCAF by binding to histones and masking them from acetylation. Endogenous INHAT associates with chromatin in vivo and blocks coactivator-mediated transcription. Biochemical purification, HAT activity assays, chromatin immunoprecipitation, transfection/transcription assays Cell High 11163245
2002 Phosphoprotein SET, found in adrenals, inhibits PP2A but not PP4, and thereby promotes 17,20 lyase activity of cytochrome P450c17, which is required for sex steroid biosynthesis. PP2A co-immunoprecipitated with P450c17 and suppression of PP2A by siRNA increased 17,20 lyase activity. PP2A/PP4 inhibitor pharmacology, co-immunoprecipitation, siRNA knockdown, enzyme activity assays in NCI-H295A adrenal cells The Journal of biological chemistry High 12444089
2003 SET is the specific inhibitor (IGAAD) of NM23-H1, a GzmA-activated DNase (GAAD). SET binds NM23-H1 and is cleaved by Granzyme A, releasing NM23-H1 to nick chromosomal DNA. SET and NM23-H1 reside together in an ER-associated complex containing pp32, HMG-2, and Ape1. After GzmA loading or CTL attack, both SET and NM23-H1 translocate to the nucleus, SET is degraded, and NM23-H1 executes caspase-independent apoptotic DNA damage. Co-immunoprecipitation, siRNA knockdown, GzmA cleavage assays, nuclear translocation imaging, CTL cytotoxicity assays Cell High 12628186
2005 In BCR/ABL-transformed cells and CML blast crisis progenitors, BCR/ABL kinase induces expression of the PP2A inhibitor SET, thereby functionally inactivating PP2A tumor suppressor activity. Pharmacological or molecular activation of PP2A in these cells suppresses BCR/ABL activity, induces BCR/ABL degradation, and promotes apoptosis and differentiation, demonstrating that SET-mediated PP2A inhibition is essential for BCR/ABL leukemogenesis. Gene expression analysis, phosphatase activity assays, molecular (siRNA) and pharmacological PP2A activation, in vivo leukemogenesis assays, cell proliferation/apoptosis/differentiation assays Cancer cell High 16286244
2006 SET binds the carboxyl region of the M3-muscarinic receptor third intracellular loop (i3 loop), as identified by GST pulldown from rat brain lysates. Endogenous SET co-immunoprecipitates with intact M3 muscarinic receptor. siRNA knockdown of SET augmented receptor-mediated intracellular calcium mobilization by ~35% without affecting EC50, indicating SET reduces M3 muscarinic receptor signaling capacity specifically. GST pulldown from brain lysates, co-immunoprecipitation, siRNA knockdown, intracellular calcium mobilization assays The Journal of biological chemistry High 17065150
2007 Proteomic analysis of SET-binding proteins using SET affinity chromatography identified CK2, eIF2α, glycogen phosphorylase (GP), and TCP1-β as SET interactors confirmed by Western blotting and co-immunoprecipitation. SET was identified as a substrate of CK2 in vitro, and SET interacts preferentially with the active (phosphorylated) form of glycogen phosphorylase. SET affinity chromatography, 2-DE, MALDI-TOF MS, Western blotting, co-immunoprecipitation, in vitro kinase assay Proteomics Medium 17309103
2011 SET/TAF-Iβ inhibits p300- and PCAF-mediated acetylation of p53 in an INHAT domain-dependent manner. SET/TAF-Iβ interacts with p53, represses transcription of p53 target genes, and blocks p53-mediated cell cycle arrest and apoptosis in response to cellular stress. In Drosophila, dSet inhibits dp53 acetylation and rescues dp53-induced apoptotic eye phenotype. Co-immunoprecipitation, HAT inhibition assays, transcription reporter assays, FACS/TUNEL/BrdU cell cycle and apoptosis assays, Drosophila genetic rescue experiments Nucleic acids research High 21911363
2011 SET nuclear oncogene directly binds the N-terminal BRCT domain of microcephalin (MCPH1). Knockdown of SET caused abnormal chromosome condensation similar to MCPH1 deficiency, and this phenotype was rescued by condensin II knockdown, placing SET upstream of condensin II in chromosome condensation control. MCPH1 missense mutations that impair SET binding fail to rescue premature chromosome condensation. Co-immunoprecipitation, siRNA knockdown, epistasis analysis by double knockdown, chromosome condensation phenotype assay in MEFs The Journal of biological chemistry High 21515671
2014 SET/TAF-Iβ inhibits p300-mediated acetylation of FoxO1 in an INHAT domain-dependent manner. SET/TAF-Iβ interacts with FoxO1 and activates transcription of the FoxO1 target gene p21, and this activation is enhanced under oxidative stress conditions. Co-immunoprecipitation, HAT inhibition assays, transcription reporter assays, oxidative stress treatment FEBS letters Medium 24983498
2015 Cytochrome c, released from mitochondria and translocated to the nucleus upon DNA damage (but not upon death receptor or stress-induced pathways), competitively inhibits SET/TAF-Iβ histone chaperone activity by binding to and locking its histone-binding domains. This blocks SET/TAF-Iβ nucleosome assembly activity. The structural basis of the cytochrome c–SET/TAF-Iβ complex was resolved by NMR spectroscopy, calorimetry, mutagenesis, and molecular docking. NMR spectroscopy, isothermal titration calorimetry, site-directed mutagenesis, molecular docking, nucleosome assembly assay, nuclear translocation imaging, competitive binding assay Proceedings of the National Academy of Sciences of the United States of America High 26216969
2015 SET/I2PP2A inhibition using OP449 and FTY720 activates PP2A in metastatic canine melanoma cells (CMeC-2), decreases cell proliferation, invasion, and colony formation, and reduces phosphorylation of p70 S6 kinase, implicating the mTOR/p70 S6K signaling pathway in SET-dependent cancer cell survival. shRNA knockdown, SET inhibitor treatment (OP449, FTY720), PP2A phosphatase activity assay, proliferation/invasion/colony formation assays, Western blotting for p70 S6K phosphorylation The Journal of veterinary medical science Medium 26062569
2017 SET protein accumulation in head and neck squamous cell carcinoma promotes DNA demethylation (via increased TET1 and 5-hydroxymethylcytosine formation) and directly binds chromatin at gene promoters to decrease histone acetylation, thereby repressing transcription of tumor suppressor genes. TSA (HDAC inhibitor) treatment reversed this transcriptional repression and also reduced SET protein levels and its chromatin binding. DNA methylation profiling, 5-methylcytidine/5-hydroxymethylcytosine quantification, chromatin immunoprecipitation (ChIP), gene expression arrays, pharmacological treatment (5-AZA, TSA) Oncotarget Medium 28460463
2022 SETBP1 binds SET protein, and based on documented SET molecular complexes (INHAT, PP2A inhibition, DNA repair, cell cycle control), altered SETBP1 dosage is postulated to influence these SET-containing pathways in brain development, providing a mechanistic framework linking SETBP1 mutations (Schinzel-Giedion syndrome and SETBP1 deficiency) to neurodevelopmental phenotypes. Literature synthesis with mechanistic pathway analysis; original binding established by prior work Frontiers in neuroscience Low 35685777

Source papers

Stage 0 corpus · 130 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2020 ShinyGO: a graphical gene-set enrichment tool for animals and plants. Bioinformatics (Oxford, England) 3448 31882993
2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 2861 17081983
2021 Gene Set Knowledge Discovery with Enrichr. Current protocols 2587 33780170
2019 WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs. Nucleic acids research 2358 31114916
2005 Towards a proteome-scale map of the human protein-protein interaction network. Nature 2090 16189514
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2009 Defining the human deubiquitinating enzyme interaction landscape. Cell 1282 19615732
2006 Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Molecular cell 1260 16916647
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2002 MLL targets SET domain methyltransferase activity to Hox gene promoters. Molecular cell 850 12453418
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2018 GSCALite: a web server for gene set cancer analysis. Bioinformatics (Oxford, England) 841 29790900
2018 VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell discovery 829 29507755
2000 DNA cloning using in vitro site-specific recombination. Genome research 815 11076863
2007 Large-scale mapping of human protein-protein interactions by mass spectrometry. Molecular systems biology 733 17353931
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2005 The SET-domain protein superfamily: protein lysine methyltransferases. Genome biology 602 16086857
2018 High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. Molecular cell 580 29395067
1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene 492 8125298
2006 Shugoshin collaborates with protein phosphatase 2A to protect cohesin. Nature 480 16541025
2023 GSCA: an integrated platform for gene set cancer analysis at genomic, pharmacogenomic and immunogenomic levels. Briefings in bioinformatics 465 36549921
2007 Gene function in mouse embryogenesis: get set for gastrulation. Nature reviews. Genetics 460 17387317
2003 Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell 439 12628186
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2010 Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science (New York, N.Y.) 421 20360068
2010 ROAST: rotation gene set tests for complex microarray experiments. Bioinformatics (Oxford, England) 418 20610611
2013 The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. The Journal of biological chemistry 413 23463506
2001 Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein. Cell 413 11163245
1996 The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A. The Journal of biological chemistry 412 8626647
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
2004 CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across species. Molecular cell 397 14759373
2005 The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer cell 396 16286244
2007 Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Molecular cell 367 17643375
2010 The p53 orchestra: Mdm2 and Mdmx set the tone. Trends in cell biology 366 20172729
1992 Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene. Molecular and cellular biology 358 1630450
1998 SET domain proteins modulate chromatin domains in eu- and heterochromatin. Cellular and molecular life sciences : CMLS 302 9487389
2015 Comprehensive characterization of the Published Kinase Inhibitor Set. Nature biotechnology 253 26501955
2019 Acute Pancreatitis: A Multifaceted Set of Organelle and Cellular Interactions. Gastroenterology 237 30660726
2008 Gene-set approach for expression pattern analysis. Briefings in bioinformatics 236 18202032
2012 EnrichNet: network-based gene set enrichment analysis. Bioinformatics (Oxford, England) 214 22962466
2016 The statistical properties of gene-set analysis. Nature reviews. Genetics 203 27070863
1995 A new set of useful cloning and expression vectors derived from pBlueScript. Gene 191 7557476
2017 Synaptic weight set by Munc13-1 supramolecular assemblies. Nature neuroscience 190 29230050
2007 Improving gene set analysis of microarray data by SAM-GS. BMC bioinformatics 186 17612399
2020 Cerebellar nuclei evolved by repeatedly duplicating a conserved cell-type set. Science (New York, N.Y.) 170 33335034
2013 Mitosis and apoptosis: how is the balance set? Current opinion in cell biology 158 23890995
2006 Extensions to gene set enrichment. Bioinformatics (Oxford, England) 151 17127676
2015 The essential gene set of a photosynthetic organism. Proceedings of the National Academy of Sciences of the United States of America 149 26508635
2016 Plant metabolism, the diverse chemistry set of the future. Science (New York, N.Y.) 141 27634523
2022 Pan-cancer profiles of the cuproptosis gene set. American journal of cancer research 140 36119826
2019 Recent advances in the CRISPR genome editing tool set. Experimental & molecular medicine 125 31685795
2020 Melatonin in flowering, fruit set and fruit ripening. Plant reproduction 117 32253624
2011 Substrate and product specificities of SET domain methyltransferases. Epigenetics 113 21847010
2002 Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17. The Journal of biological chemistry 112 12444089
2017 Histone Methylation by SET Domain Proteins in Fungi. Annual review of microbiology 105 28715960
2007 Protein synthesis in liposomes with a minimal set of enzymes. Biochemical and biophysical research communications 101 17850764
2019 The barcode, UMI, set format and BUStools. Bioinformatics (Oxford, England) 100 31073610
2018 The racially diverse affective expression (RADIATE) face stimulus set. Psychiatry research 99 29910020
1992 Neurotransmitters as neurotrophic factors: a new set of functions. International review of neurobiology 99 1350276
1994 Purification and characterization of two putative HLA class II associated proteins: PHAPI and PHAPII. Biological chemistry Hoppe-Seyler 91 8192856
2019 A consensus set of genetic vulnerabilities to ATR inhibition. Open biology 84 31506018
2018 How the evolution of multicellularity set the stage for cancer. British journal of cancer 83 29337961
2015 Test set bias affects reproducibility of gene signatures. Bioinformatics (Oxford, England) 77 25788628
2010 Under pressure, cell walls set the pace. Trends in plant science 75 20483654
2007 Comparative evaluation of gene-set analysis methods. BMC bioinformatics 71 17988400
2008 Gene-set analysis and reduction. Briefings in bioinformatics 67 18836208
2015 Evolving Catalytic Properties of the MLL Family SET Domain. Structure (London, England : 1993) 66 26320581
2018 Single olfactory receptors set odor detection thresholds. Nature communications 62 30038239
2008 DOCKGROUND protein-protein docking decoy set. Bioinformatics (Oxford, England) 59 18812365
2021 Using azobenzene photocontrol to set proteins in motion. Nature reviews. Chemistry 58 37117294
2021 Ruler elements in chromatin remodelers set nucleosome array spacing and phasing. Nature communications 54 34050140
2015 Structural basis for inhibition of the histone chaperone activity of SET/TAF-Iβ by cytochrome c. Proceedings of the National Academy of Sciences of the United States of America 53 26216969
2010 Gene set analysis exploiting the topology of a pathway. BMC systems biology 53 20809931
2022 MRSCloud: A cloud-based MRS tool for basis set simulation. Magnetic resonance in medicine 52 35775808
2018 Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance. Cell reports 52 30463020
2017 Minimal tool set for a prokaryotic circadian clock. BMC evolutionary biology 49 28732467
2011 Inhibition of p53 acetylation by INHAT subunit SET/TAF-Iβ represses p53 activity. Nucleic acids research 49 21911363
2022 A transcriptional landscape underlying sugar import for grain set in maize. The Plant journal : for cell and molecular biology 48 35020972
2012 Chromatin insulator elements: establishing barriers to set heterochromatin boundaries. Epigenomics 47 22332659
2020 Optogenetics and biosensors set the stage for metabolic cybergenetics. Current opinion in biotechnology 46 32932048
2013 On your histone mark, SET, methylate! Epigenetics 46 23625014
2017 Ranking metrics in gene set enrichment analysis: do they matter? BMC bioinformatics 45 28499413
2019 A set of microRNAs coordinately controls tumorigenesis, invasion, and metastasis. Proceedings of the National Academy of Sciences of the United States of America 44 31704767
2017 Easy and efficient ensemble gene set testing with EGSEA. F1000Research 44 29333246
2016 SET/MLL family proteins in hematopoiesis and leukemia. International journal of hematology 44 27796741
2004 Peroxisome membrane biogenesis: the stage is set. Current biology : CB 43 15186768
2018 Perceiving set mean and range: Automaticity and precision. Journal of vision 41 30267075
2006 A unique set of SH3-SH3 interactions controls IB1 homodimerization. The EMBO journal 40 16456539
2018 Concurrent processes set E. coli cell division. Science advances 39 30417095
2013 Graphite Web: Web tool for gene set analysis exploiting pathway topology. Nucleic acids research 37 23666626
2000 Towards a covering set of protein family profiles. Progress in biophysics and molecular biology 37 11063778
2015 Niosome-loaded cold-set whey protein hydrogels. Food chemistry 36 26593471
2002 Minreg: inferring an active regulator set. Bioinformatics (Oxford, England) 36 12169555
2007 Chlamydial SET domain protein functions as a histone methyltransferase. Microbiology (Reading, England) 35 17259630
2007 GAzer: gene set analyzer. Bioinformatics (Oxford, England) 35 17468122
2020 PRIMPOL ready, set, reprime! Critical reviews in biochemistry and molecular biology 34 33179522
2018 A comprehensive and perspective view of oncoprotein SET in cancer. Cancer medicine 33 29749127
2017 SMCHD1 regulates a limited set of gene clusters on autosomal chromosomes. Skeletal muscle 31 28587678
2009 Ready, set, internalize: mechanisms and regulation of GLUT4 endocytosis. Bioscience reports 31 19143591
2020 A limited set of transcriptional programs define major cell types. Genome research 30 32759341
2011 SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation. The Journal of biological chemistry 29 21515671
2020 Cellulose nanofibers production using a set of recombinant enzymes. Carbohydrate polymers 28 33483031
2017 GSAR: Bioconductor package for Gene Set analysis in R. BMC bioinformatics 28 28118818
2014 Unraveling the signal scenario of fruit set. Planta 27 24659051
2011 Inferring disease and gene set associations with rank coherence in networks. Bioinformatics (Oxford, England) 27 21824970
2016 Integrated gene set analysis for microRNA studies. Bioinformatics (Oxford, England) 26 27324197
2020 Genome Improvement and Core Gene Set Refinement of Fugacium kawagutii. Microorganisms 24 31940756
2014 Inhibition of FoxO1 acetylation by INHAT subunit SET/TAF-Iβ induces p21 transcription. FEBS letters 24 24983498
2011 Gene set analysis of purine and pyrimidine antimetabolites cancer therapies. Pharmacogenetics and genomics 24 21869733
2007 Proteomic analysis of SET-binding proteins. Proteomics 23 17309103
2019 Graph Algorithms for Condensing and Consolidating Gene Set Analysis Results. Molecular & cellular proteomics : MCP 22 31142576
2019 Relating categorization to set summary statistics perception. Attention, perception & psychophysics 22 31243687
2017 SET oncoprotein accumulation regulates transcription through DNA demethylation and histone hypoacetylation. Oncotarget 22 28460463
2018 Using set theory to reduce redundancy in pathway sets. BMC bioinformatics 20 30340461
2022 Putative Roles of SETBP1 Dosage on the SET Oncogene to Affect Brain Development. Frontiers in neuroscience 19 35685777
2020 The MLL/SET family and haematopoiesis. Biochimica et biophysica acta. Gene regulatory mechanisms 19 32389825
2019 Expression of V-set immunoregulatory receptor in malignant mesothelioma. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 19 31363159
2006 The proto-oncogene SET interacts with muscarinic receptors and attenuates receptor signaling. The Journal of biological chemistry 19 17065150
2024 Probe set selection for targeted spatial transcriptomics. Nature methods 18 39558096
2015 The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma. The Journal of veterinary medical science 18 26062569
2020 GeneSetCluster: a tool for summarizing and integrating gene-set analysis results. BMC bioinformatics 17 33028195
2018 SET alpha and SET beta mRNA isoforms in chronic lymphocytic leukaemia. British journal of haematology 17 30443898
2014 A conserved set of maternal genes? Insights from a molluscan transcriptome. The International journal of developmental biology 17 25690965
2023 Modulating auxin response stabilizes tomato fruit set. Plant physiology 16 37032117
2015 miSEA: microRNA set enrichment analysis. Bio Systems 16 26093049