Affinage

CYCS

Cytochrome c · UniProt P99999

Length
105 aa
Mass
11.7 kDa
Annotated
2026-06-09
86 papers in source corpus 7 papers cited in narrative 8 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 5/5 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CYCS (cytochrome c, somatic) operates at the intersection of mitochondrial respiration and intrinsic apoptosis, and its dysfunction underlies autosomal dominant thrombocytopenia-4 (PMID:30051457, PMID:39191490). In the apoptotic arm, cytochrome c physically associates with Apaf1 to drive the intrinsic mitochondrial death pathway; this Apaf1/Cycs interaction is upregulated in a cardiomyoblast HFpEF model and its reduction suppresses apoptosis (PMID:41142248). Disease-associated CYCS variants act through loss of function: an in-frame C-terminal helix deletion (p.Lys101del) reduces cytochrome c protein and impairs the mitochondrial respiratory chain in a yeast complementation model (PMID:30051457), and a CRISPR knock-in of p.Thr20Ile in megakaryoblasts lowers CYCS protein while raising mitochondrial respiration and CD9 surface expression and, unexpectedly, dampens caspase activation — implicating caspase dysregulation in defective platelet production (PMID:39191490). Consistent with a role in platelet biogenesis, cytochrome c is upregulated during megakaryoblast differentiation (PMID:29287084), and CYCS-mutant megakaryocytes produce platelets both by proplatelet-dependent release and by a microenvironment-dependent proplatelet-independent route (PMID:27861742). CYCS expression is controlled transcriptionally — zinc represses the promoter through MTF-1 and HNF-1α binding, lowering cytochrome c and reducing hepatocyte apoptosis (PMID:34208159) — and post-transcriptionally by miR-29b, which targets the CYCS 3'-UTR to elevate ROS and impair oocyte maturation (PMID:39342691).

Mechanistic history

Synthesis pass · year-by-year structured walk · 7 steps
  1. 2016 Medium

    Established that CYCS-mutant megakaryocytes generate platelets by two distinct routes, one of which depends on the bone marrow microenvironment, clarifying how cytochrome c dysfunction perturbs platelet production.

    Evidence In vitro culture of patient-derived megakaryocytes with electron microscopy and microtubule coil morphology comparison

    PMID:27861742

    Open questions at the time
    • The molecular mechanism linking CYCS mutation to the proplatelet-independent route is not defined
    • The microenvironmental signal involved was not identified
    • The in vitro system could not recapitulate the proplatelet-independent phenotype
  2. 2017 Medium

    Showed cytochrome c is upregulated during megakaryoblast differentiation, tying CYCS respiratory-chain function to the differentiation program rather than mere proliferation.

    Evidence Western blotting of cytochrome c and cytochrome c oxidase subunit II in megakaryoblastic cell lines under PMA induction versus cell density

    PMID:29287084

    Open questions at the time
    • The transcriptional regulators driving the differentiation-associated increase are not identified
    • Causal contribution of cytochrome c upregulation to differentiation was not tested
  3. 2018 Medium

    Demonstrated that a thrombocytopenia-associated CYCS C-terminal deletion causes loss of function, reducing cytochrome c expression and impairing respiratory chain activity.

    Evidence Yeast complementation with respiratory chain functional readout plus in silico folding analysis and whole exome sequencing

    PMID:30051457

    Open questions at the time
    • Yeast model does not capture megakaryocyte-specific consequences
    • Effect on the apoptotic/caspase arm was not assessed
  4. 2021 Medium

    Defined transcriptional control of CYCS by zinc, showing MTF-1 and HNF-1α bind its promoter to repress expression and limit apoptosis.

    Evidence Promoter-luciferase deletion constructs and ChIP for MTF-1/HNF-1α with apoptosis staining in yellow catfish hepatocytes

    PMID:34208159

    Open questions at the time
    • Conservation of this Zn/MTF-1/HNF-1α regulation in mammalian or megakaryocytic contexts is untested
    • Teleost model limits direct human relevance
  5. 2024 High

    Identified miR-29b as a direct post-transcriptional repressor of CYCS, linking reduced cytochrome c to ROS accumulation and impaired oocyte maturation.

    Evidence Dual-luciferase reporter, miR-29b mimic/knockdown, and CYCS overexpression rescue with ROS and COC expansion readouts in porcine granulosa cells

    PMID:39342691

    Open questions at the time
    • Mechanism connecting cytochrome c level to ROS modulation is not resolved
    • Relevance to human reproduction or to platelet biology not established
  6. 2024 High

    Used a CRISPR knock-in to show the p.Thr20Ile variant acts by loss of function, lowering CYCS protein and caspase activation while altering respiration and differentiation markers.

    Evidence CRISPR/Cas9 knock-in in MEG-01 cells with caspase, respiration, surface antigen, ploidy and protein readouts

    PMID:39191490

    Open questions at the time
    • Contrast with prior gain-of-function variants not mechanistically reconciled
    • How reduced caspase activation translates to reduced platelet output is not established
  7. 2025 Medium

    Demonstrated a physical Apaf1/Cycs interaction driving intrinsic apoptosis in a cardiac disease model, confirming the apoptosome partnership in vivo.

    Evidence Co-immunoprecipitation of Apaf1 and Cycs in H9c2 cardiomyoblasts and mouse myocardium with TUNEL in an HFpEF model

    PMID:41142248

    Open questions at the time
    • Binding shown by single-method co-IP without reciprocal or structural validation
    • Direct causal link between the interaction and apoptosis was inferred from a pharmacologic intervention

Open questions

Synthesis pass · forward-looking unresolved questions
  • How CYCS pathogenic variants produce divergent effects on caspase activation (loss versus gain) and how these structural and biochemical changes mechanistically reduce platelet production in human megakaryocytes remains unresolved.
  • No experimentally validated structure-function model reconciling variant effects
  • Megakaryocyte-specific apoptotic threshold governing platelet release not defined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016491 oxidoreductase activity 2
Localization
GO:0005739 mitochondrion 2
Pathway
R-HSA-1430728 Metabolism 2 R-HSA-5357801 Programmed Cell Death 2
Partners
APAF1
Complex memberships
apoptosome

Evidence

Reading pass · 8 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 Megakaryocytes from patients carrying CYCS mutations (Thrombocytopenia Cargeeg) produce platelets by two distinct mechanisms: proplatelet-dependent release (yielding platelets with normal marginal microtubule coils) and a proplatelet-independent release into extravascular bone marrow space (yielding platelet-like structures lacking the marginal microtubule coil). The proplatelet-independent phenotype could not be recapitulated in vitro, indicating it depends on the interaction between CYCS-mutant megakaryocytes and their bone marrow microenvironment rather than being an intrinsic cell property. In vitro culture of megakaryocytes derived from peripheral blood of thrombocytopenia subjects; electron microscopy of bone marrow platelet-like structures; comparison of microtubule coil morphology between circulating platelets and extravascular platelet-like structures British journal of haematology Medium 27861742
2018 A novel in-frame deletion in the CYCS C-terminal α-helix (p.Lys101del) causes thrombocytopenia by loss-of-function: in a yeast complementation model, this mutation resulted in significantly reduced cytochrome c protein expression and functional defects in the mitochondrial respiratory chain, establishing that cytochrome c loss-of-function underlies the thrombocytopenia phenotype. Yeast model system complementation; assessment of mitochondrial respiratory chain function; in silico structural analysis of protein folding stability; whole exome sequencing for variant identification Clinical genetics Medium 30051457
2017 Cytochrome c (CYCS) expression is upregulated during megakaryoblast differentiation induced by phorbol ester (PMA) and also increases with cell density. A concomitant increase in cytochrome c oxidase subunit II occurs with PMA but not with increased cell density, suggesting that upregulation of the mitochondrial respiratory chain is a specific feature of differentiation rather than density-dependent proliferation. Western blotting of endogenous cytochrome c and cytochrome c oxidase subunit II in megakaryoblastic cell lines (K562, Dami, MEG-01) under PMA-induced differentiation and varying cell densities PloS one Medium 29287084
2024 A novel CYCS variant (p.Thr20Ile) introduced into a megakaryoblast cell line via CRISPR/Cas9 decreases CYCS protein expression, increases mitochondrial respiration and CD9 cell surface antigen expression, and unexpectedly abates caspase activation — contrasting with previously reported gain-of-function effects of other CYCS variants. This indicates the variant acts via loss-of-function with respect to caspase pathway activation, and suggests that caspase dysregulation may contribute to thrombocytopenia. CRISPR/Cas9-mediated gene editing in MEG-01 megakaryoblast cells; caspase activity assays; mitochondrial respiration measurement; flow cytometry for cell surface antigens and ploidy; Western blot for CYCS protein expression British journal of haematology High 39191490
2024 miR-29b directly targets the 3'-UTR of CYCS mRNA (confirmed by dual-luciferase reporter assay), downregulating cytochrome c at both mRNA and protein levels. This leads to reactive oxygen species (ROS) accumulation in granulosa cells, which inhibits cumulus-oocyte complex (COC) expansion and oocyte maturation in vitro; overexpression of CYCS reverses ROS accumulation and rescues COC expansion. Dual-luciferase reporter assay with CYCS 3'-UTR; miR-29b mimic/knockdown in porcine granulosa cells; ROS measurement; COC expansion assay; oocyte maturation scoring; CYCS mRNA and protein quantification Animal reproduction science High 39342691
2021 In yellow catfish, the CYCS promoter contains functional metal-responsive element (MRE) and HNF-1α binding sites. Zinc (Zn) decreases CYCS promoter activity and reduces CYCS mRNA and protein expression; MTF-1 and HNF-1α bind directly to the CYCS promoter and negatively regulate its activity, and Zn decreases HNF-1α binding to the CYCS promoter. This mechanism links Zn-mediated transcriptional repression of CYCS to reduced hepatocyte apoptosis. Promoter-reporter (luciferase) assay with deletion constructs; chromatin immunoprecipitation (ChIP) for MTF-1 and HNF-1α binding to CYCS promoter; Western blot and qRT-PCR for CYCS protein and mRNA; Annexin V-FITC/PI staining for apoptosis International journal of molecular sciences Medium 34208159
2025 In a mouse HFpEF model, the interaction between Apaf1 and Cycs (cytochrome c) is upregulated in cardiomyoblasts, driving apoptosis via the intrinsic mitochondrial pathway. Combined treatment with thymoquinone and aerobic exercise downregulates the Apaf1/Cycs interaction, thereby suppressing cardiomyocyte apoptosis. This interaction was demonstrated by co-immunoprecipitation. Co-immunoprecipitation of Apaf1 and Cycs in H9c2 cardiomyoblasts and mouse myocardium; TUNEL assay for apoptosis; HFpEF mouse model with L-NAME/high-fat diet Frontiers in pharmacology Medium 41142248
2024 Computational structural analysis of disease-associated CYCS variants linked to thrombocytopenia-4 shows that all pathogenic variants occur at evolutionarily conserved sites. Molecular dynamics simulations (500 ns) reveal that these variants reduce protein stability, increase flexibility particularly in the Ω-loops, and displace Ω-loops away from the heme iron, weakening critical hydrogen bonds and opening the heme active site. Specific variants are predicted to affect phosphorylation sites (T20I, V21G, Y49H) and ubiquitination sites (G42S, A52T, A52V, T103I). This open heme conformation may enhance peroxidase activity and thereby promote apoptosis, contributing to reduced platelet production. Molecular dynamics simulation (500 ns); bioinformatics analysis of evolutionary conservation; in silico prediction of phosphorylation and ubiquitination sites bioRxiv (preprint)preprint Low

Source papers

Stage 0 corpus · 86 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1985 Each of three "TATA elements" specifies a subset of the transcription initiation sites at the CYC-1 promoter of Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America 308 3001709
1984 The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes. The Journal of biological chemistry 240 6142891
1999 PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription. Molecular and cellular biology 202 10409723
2006 Phylogenetic analysis of the "ECE" (CYC/TB1) clade reveals duplications predating the core eudicots. Proceedings of the National Academy of Sciences of the United States of America 151 16754863
1982 Guanine nucleotide inhibition of cyc- S49 mouse lymphoma cell membrane adenylyl cyclase. The Journal of biological chemistry 129 6757248
2000 dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complex. The Journal of neuroscience : the official journal of the Society for Neuroscience 107 10684876
2011 Evolution and diversification of the CYC/TB1 gene family in Asteraceae--a comparative study in Gerbera (Mutisieae) and sunflower (Heliantheae). Molecular biology and evolution 100 22101417
1983 Occurrence of a hormone-sensitive inhibitory coupling component of the adenylate cyclase in S49 lymphoma cyc- variants. Proceedings of the National Academy of Sciences of the United States of America 95 6135205
2008 Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. Proceedings of the National Academy of Sciences of the United States of America 83 18388203
1999 Eco Cyc: encyclopedia of Escherichia coli genes and metabolism. Nucleic acids research 65 9847140
1983 Adenylate cyclase inhibition and GTPase stimulation by somatostatin in S49 lymphoma cyc- variants are prevented by islet-activating protein. FEBS letters 60 6134642
1985 Epinephrine-induced sequestration of the beta-adrenergic receptor in cultured S49 WT and cyc- lymphoma cells. Journal of cyclic nucleotide and protein phosphorylation research 57 2984267
2008 Rhythmic E-box binding by CLK-CYC controls daily cycles in per and tim transcription and chromatin modifications. Molecular and cellular biology 53 18474612
1983 Inhibitory regulation of adenylyl cyclase in the absence of stimulatory regulation. Requirements and kinetics of guanine nucleotide-induced inhibition of the cyc- S49 adenylyl cyclase. The Journal of biological chemistry 53 6685126
1987 Beta-adrenergic receptor desensitization of wild-type but not cyc lymphoma cells unmasked by submillimolar Mg2+. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 52 2820824
1982 The effects of forskolin on adenylate cyclase in S49 wild type and cyc- cells. Journal of cyclic nucleotide research 49 6891945
1981 Epinephrine desensitization of adenylate cyclase from cyc- and S49 cultured lymphoma cells. Journal of cyclic nucleotide research 49 7287968
2016 Identification and Characterization of CYC-Like Genes in Regulation of Ray Floret Development in Chrysanthemum morifolium. Frontiers in plant science 48 27872631
2012 CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila. Genes & development 40 23154984
2011 Mechanisms involved in reduction of ochratoxin A produced by Aspergillus westerdijkiae using Debaryomyces hansenii CYC 1244. International journal of food microbiology 39 21899908
2008 Expression differentiation of CYC-like floral symmetry genes correlated with their protein sequence divergence in Chirita heterotricha (Gesneriaceae). Development genes and evolution 37 18592267
1985 Properties of beta-adrenergic receptors of cultured mammalian cells. Interaction of receptors with a guanine nucleotide-binding protein in membranes prepared from L6 myoblasts and from wild-type and cyc- S49 lymphoma cells. The Journal of biological chemistry 35 2997214
1984 Interaction of the stimulatory and inhibitory regulatory proteins of the adenylyl cyclase system with the catalytic component of cyc-S49 cell membranes. The Journal of biological chemistry 35 6436244
2015 Analysis of the CYC/TB1 class of TCP transcription factors in basal angiosperms and magnoliids. The Plant journal : for cell and molecular biology 33 25557238
1988 Interaction of beta-adrenergic receptors with the inhibitory guanine nucleotide-binding protein of adenylate cyclase in membranes prepared from cyc- S49 lymphoma cells. Biochemical pharmacology 32 2848525
2017 Evolution and Expression Patterns of CYC/TB1 Genes in Anacyclus: Phylogenetic Insights for Floral Symmetry Genes in Asteraceae. Frontiers in plant science 30 28487706
2010 Isolation and functional characterization of lycopene beta-cyclase (CYC-B) promoter from Solanum habrochaites. BMC plant biology 30 20380705
1991 Expression and characterization of the long and short splice variants of GS alpha in S49 cyc- cells. Molecular pharmacology 29 1646945
2008 The histone-deacetylase inhibitor MS-275 and the CDK-inhibitor CYC-202 promote anti-tumor effects in hepatoma cell lines. Oncology reports 27 18949429
1994 Sensitization of adenylate cyclase by halothane in human myocardium and S49 lymphoma wild-type and cyc- cells: evidence for inactivation of the inhibitory G protein Gi alpha. Molecular pharmacology 26 8145725
1983 Somatostatin-induced stimulation of a high-affinity GTPase in membranes of S49 lymphoma cyc- and H21a variants. Molecular pharmacology 26 6136902
2016 Megakaryocytes from CYCS mutation-associated thrombocytopenia release platelets by both proplatelet-dependent and -independent processes. British journal of haematology 25 27861742
2018 Evolutionary diversification of CYC/TB1-like TCP homologs and their recruitment for the control of branching and floral morphology in Papaveraceae (basal eudicots). The New phytologist 24 29949661
1986 Phase II trial of misonidazole (MISO) and cyclophosphamide (CYC) in metastatic renal cell carcinoma. International journal of radiation oncology, biology, physics 24 3759565
2020 A CYC/TB1-type TCP transcription factor controls spikelet meristem identity in barley. Journal of experimental botany 23 32915968
2018 A novel CYCS mutation in the α-helix of the CYCS C-terminal domain causes non-syndromic thrombocytopenia. Clinical genetics 23 30051457
2003 Cloning of Cyc (Bmal1) homolog in Bombyx mori: structural analysis and tissue specific distributions. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 21 12628385
2004 CYC-202 Cyclacel. Current opinion in investigational drugs (London, England : 2000) 20 15648953
2023 Medicarpin suppresses proliferation and triggeres apoptosis by upregulation of BID, BAX, CASP3, CASP8, and CYCS in glioblastoma. Chemical biology & drug design 18 37515387
2003 A PERIOD inhibitor buffer introduces a delay mechanism for CLK/CYC-activated transcription. FEBS letters 18 14644439
1989 Reconstitution of cyc- S49 membranes by in vitro translated Gs alpha. Membrane anchorage and functional implications. FEBS letters 18 2502436
1992 Down-regulation of beta-adrenergic receptors by pindolol in Gs alpha-transfected S49 cyc- murine lymphoma cells. Journal of neurochemistry 15 1310718
1983 Effect of dithiothreitol on the beta-adrenergic receptor of S49 wild type and cyc- lymphoma cells: decreased affinity of the ligand-receptor interaction. Journal of cyclic nucleotide and protein phosphorylation research 15 6321573
2016 Neofunctionalization of Chromoplast Specific Lycopene Beta Cyclase Gene (CYC-B) in Tomato Clade. PloS one 14 27070417
2021 Declined expressions of vast mitochondria-related genes represented by CYCS and transcription factor ESRRA in skeletal muscle aging. Bioengineered 13 34229541
2019 By regulating miR-182-5p/BCL10/CYCS, sufentanil reduces the apoptosis of umbilical cord mesenchymal stem cells caused by ropivacaine. Bioscience trends 13 30773504
1979 Yeast cytochrome c-specific protein-lysine methyltransferase: coordinate regulation with cytochrome c and activities in cyc mutants. Journal of bacteriology 13 222727
2022 A CYC-RAD-DIV-DRIF interaction likely pre-dates the origin of floral monosymmetry in Lamiales. EvoDevo 11 35093179
2022 A Novel Heterozygous Pathogenic Variation in CYCS Gene Cause Autosomal Dominant Non-Syndromic Thrombocytopenia 4 in a Large Chinese Family. Frontiers in genetics 11 35126455
2002 Aryl-substituted and benzo-annulated cyc/osal-derivatives of 2',3'-dideoxy-2',3'-didehydrothymidine monophosphate--correlation of structure, hydrolysis properties and anti-HIV activity. Antiviral chemistry & chemotherapy 11 12238530
1987 Reconstitution of the Gs protein from B16 melanoma clones of high and low experimental metastatic potential into S49 cyc-membranes. Biochemical and biophysical research communications 11 3115261
2023 Advances in Research on the Regulation of Floral Development by CYC-like Genes. Current issues in molecular biology 9 36975501
2022 The 'Candidatus Phytoplasma mali' effector protein SAP11CaPm interacts with MdTCP16, a class II CYC/TB1 transcription factor that is highly expressed during phytoplasma infection. PloS one 9 36520844
2019 Expression of a Chromoplast-Specific Lycopene β-Cyclase Gene (CYC-B) Is Implicated in Carotenoid Accumulation and Coloration in the Loquat. Biomolecules 9 31847172
2023 68Ga-cyc-DX600 PET/CT in ACE2-targeted tumor imaging. European journal of nuclear medicine and molecular imaging 8 36847824
2021 An Optimized Transformation System and Functional Test of CYC-Like TCP Gene CpCYC in Chirita pumila (Gesneriaceae). International journal of molecular sciences 8 33925272
2019 A novel data processing method CyC* for quantitative real time polymerase chain reaction minimizes cumulative error. PloS one 8 31185064
2024 A novel thrombocytopenia-4-causing CYCS gene variant decreases caspase activity: Three-generation study. British journal of haematology 7 39191490
2022 cyc-DEP: Cyclic immunofluorescence profiling of particles collected using dielectrophoresis. Electrophoresis 7 35753078
1992 Prolonged activation of inhibitory somatostatin receptors increases adenylate cyclase activity in wild-type and Gs alpha-deficient (cyc-) S49 mouse lymphoma cells. Cellular signalling 7 1329904
2021 Identification and assessment of alleles in the promoter of the Cyc-B gene that modulate levels of β-carotene in ripe tomato fruit. The plant genome 6 33605077
2023 A new formulation of dezocine, Cyc-dezocine, reduces oxycodone self-administration in female and male rats. Neuroscience letters 5 37714288
2021 Investigation of Cyc1 protein structure stability after H53I mutation using computational approaches to improve redox potential. Journal of molecular graphics & modelling 5 33647753
2017 Differentiation and cell density upregulate cytochrome c levels in megakaryoblastic cell lines: Implications for analysis of CYCS-associated thrombocytopenia. PloS one 5 29287084
1994 Cell cycle arrest by prostaglandin A1 at the G1/S phase interface with up-regulation of oncogenes in S-49 cyc- cells. Journal of cellular biochemistry 5 8200906
2024 [99mTc]Tc-labeled cyc-DX600-HYNIC as a SPECT probe for ACE2-specific pancreatic cancer imaging. American journal of nuclear medicine and molecular imaging 3 38737645
2024 MiR-29b inhibits COC expansion and oocyte in vitro maturation via induction of ROS by targeting CYCS. Animal reproduction science 3 39342691
2021 Functional Analysis of the Promoter Regions of Two Apoptosis-Related Genes (Bcl-2 and Cycs) and Their Regulation by Zn in Yellow Catfish. International journal of molecular sciences 3 34208159
2020 Expression and Function Studies of CYC/TB1-Like Genes in the Asymmetric Flower Canna (Cannaceae, Zingiberales). Frontiers in plant science 3 33343594
2017 A wild origin of the loss-of-function lycopene beta cyclase (CYC-b) allele in cultivated, red-fleshed papaya (Carica papaya). American journal of botany 3 28082282
1992 Comparison of the properties of the CsA analogs monoacetyl CyC (o-acetyl-threonine2 cyclosporin) and methyl-alanyl CsA (N-methyl-L-alanyl6 cyclosporin); monoacetyl cyclosporin is immunosuppressive without binding to cyclophilin. Clinical and experimental immunology 3 1628422
2021 Differential expression of serum GBP-28, NBP-Cyc 3 and TIMP-1 complicates pregnancy in hypertensive disorder pregnancy. Journal of reproductive immunology 2 33601303
2020 [Role of CYCS in the cytogenesis and apoptosis of male germ cells and its clinical application]. Zhonghua nan ke xue = National journal of andrology 2 33346968
2018 Generation and classification of transcriptomes in two Croomia species and molecular evolution of CYC/TB1 genes in Stemonaceae. Plant diversity 2 30740572
1990 Divergent regulation of beta 2-adrenoceptors and adenylate cyclase in the Cyc- mouse T lymphoma cell line TL2-9. Immunobiology 2 1980264
1988 Tumorigenicity of the cyc- variant of the S49 murine lymphoma deficient in the Gs-alpha subunit of adenylate cyclase. Cancer research 2 2825980
2022 Evaluation of Cyc1 protein stability in Acidithiobacillus ferrooxidans bacterium after E121D mutation by molecular dynamics simulation to improve electron transfer. Journal of microbiology (Seoul, Korea) 1 35286603
2026 Autosomal dominant thrombocytopenia associated with the CYCS p.Arg92Gly variant: clinical characterization of an additional family and observation of antiplatelet tolerance. Platelets 0 41676885
2025 Thymoquinone and aerobic exercise mitigate HFpEF-induced cardiac injury via Apaf1/Cycs axis regulation. Frontiers in pharmacology 0 41142248
2025 Recurrent spontaneous renal bleeding in a patient with a CYCS-gene related inherited thrombocytopaenia and ischaemic heart disease. BMJ case reports 0 41218956
2025 CYCS-related thrombocytopenia in three Japanese families with a novel variant in one family. International journal of hematology 0 41455048
2024 Oligo cyc-DEP: On-chip cyclic immunofluorescence profiling of cell-derived nanoparticles. Electrophoresis 0 39049673
2016 THE CASE OF T-CELL LARGE GRANULAR LYPHOCYTE LEUKEMIA PRESENTED AS TRANSFUSION DEPENDENT ANEMIA WITH SUSTAINED RESPONSE TO CYC- LOSPORINE A THERAPY: CASE REPORT. Medicinski pregled 0 29693864
2014 Crystallization and preliminary X-ray diffraction analysis of the diterpene cyclooctatin synthase (CYC) from Streptomyces sp. LZ35. Acta crystallographica. Section F, Structural biology communications 0 24598929
1984 [The measurement of N-protein activity in plasma membranes: the comparison of assay methods by reconstitution of cyc- membranes and cholera toxin-catalyzed ADP ribosylation]. Nihon Naibunpi Gakkai zasshi 0 6434354
1983 Expression of the yeast CYC genes and CYC1/GalK fusion genes on yeast plasmids. Gene amplification and analysis 0 6101026

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