Affinage

CDCA8

Borealin · UniProt Q53HL2

Length
280 aa
Mass
31.3 kDa
Annotated
2026-04-28
83 papers in source corpus 19 papers cited in narrative 19 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CDCA8 (Borealin/DasraB) is a core subunit of the Chromosomal Passenger Complex (CPC) essential for bipolar spindle assembly, chromosome segregation, and cytokinesis during both mitosis and meiosis. Homozygous knockout in mice is embryonic lethal by E5.5 due to mitotic failure, microtubule disorganization, and p53-independent apoptosis, while haploinsufficiency disrupts thyroid development and predisposes to papillary-like thyroid tumors with ERK pathway activation (PMID:18337066, PMID:37964961). CDCA8 transcription is activated by NF-Y and CREB1 at its promoter, by MYBL2, and through an EZH2-dependent mechanism involving both H3K27me3-mediated repression of let-7b (which targets CDCA8 mRNA) and methyltransferase-independent E2F1 recruitment to the CDCA8 promoter (PMID:26170459, PMID:35094010, PMID:33575078). Post-transcriptionally, YTHDF3 recognizes m6A modifications on the CDCA8 3′UTR and promotes its translation via eIF3A, while USP35 deubiquitinates CDCA8 protein to prevent proteasomal degradation (PMID:41565643, PMID:42002994).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 2008 High

    Establishing CDCA8 as an essential CPC subunit for mitotic chromosome segregation resolved whether Borealin was functionally required in vivo or merely a structural passenger.

    Evidence Targeted gene knockout in mice yielding E5.5 lethality with mitotic defects, centromere CPC loss, and p53-independent apoptosis

    PMID:18337066

    Open questions at the time
    • Mechanism by which CDCA8 loss triggers apoptosis independent of p53 is not defined
    • Contribution of individual CPC subunits versus the holocomplex not resolved
  2. 2015 High

    Identifying NF-Y and CREB1 as direct transcriptional activators of the CDCA8 promoter established the first transcriptional regulatory framework for CDCA8 expression in stem cells and cancer.

    Evidence EMSA, promoter-reporter mutagenesis, NF-Y overexpression/knockdown, transgenic mouse reporter

    PMID:26170459

    Open questions at the time
    • How NF-Y isoform switching (short vs long NF-YA) quantitatively tunes CDCA8 levels across cell types is unclear
    • Whether CREB1 and NF-Y cooperate or act independently at the endogenous locus is not resolved
  3. 2019 Medium

    Demonstration that KIF18B binds the CDCA8 promoter and activates its transcription revealed an unexpected transcriptional role for a kinesin motor protein upstream of CPC expression.

    Evidence ChIP assay for KIF18B at the CDCA8 promoter, qRT-PCR, cell cycle analysis, xenograft

    PMID:31875977

    Open questions at the time
    • Mechanism by which a kinesin acts as a transcription factor is not explained
    • No structural or co-factor basis for KIF18B DNA binding provided
  4. 2020 Medium

    Showing CDCA8 is required for bipolar spindle assembly in human oocyte meiosis extended its known function beyond somatic mitosis to female gametogenesis.

    Evidence RNAi knockdown in human GV-stage oocytes, immunofluorescence, live-cell imaging of meiotic progression

    PMID:32088244

    Open questions at the time
    • Whether CDCA8 meiotic function is CPC-dependent or involves meiosis-specific partners is unknown
    • Effects on aneuploidy rates and fertility outcomes not assessed
  5. 2021 Medium

    CDCA8 silencing was shown to cause G2/M arrest, impair RAD51 recruitment to DNA damage foci, and sensitize cancer cells to PARP inhibitors, linking CPC function to the DNA damage response and chemosensitivity.

    Evidence siRNA knockdown in ovarian cancer cells, comet assay, RAD51 immunofluorescence, flow cytometry; MYBL2 ChIP identifying it as upstream activator

    PMID:33575078 PMID:33801424

    Open questions at the time
    • Whether CDCA8 directly influences RAD51 loading or this is secondary to mitotic arrest is not distinguished
    • Direct MYBL2 binding to the CDCA8 promoter shown by ChIP in one study only
  6. 2022 High

    Dissection of EZH2's dual mechanism — H3K27me3-dependent let-7b repression and methyltransferase-independent E2F1 recruitment — revealed how epigenetic and transcription-factor pathways converge to upregulate CDCA8 in cancer.

    Evidence ChIP-seq, RNA-seq, miRNA profiling, let-7b reporter assays, EZH2 catalytic mutant analysis in prostate cancer

    PMID:35094010

    Open questions at the time
    • Relative quantitative contribution of the two EZH2 arms to CDCA8 levels not determined
    • Whether this dual mechanism operates outside prostate cancer is untested
  7. 2022 Medium

    Discovery that CDCA8 forms a complex with SNAI2 to transcriptionally activate CD44 established a non-CPC, transcription-regulatory function for CDCA8 in cancer cell invasion.

    Evidence Co-IP, ChIP-qPCR of CDCA8/SNAI2 at the CD44 promoter, dual-luciferase reporter in pancreatic cancer

    PMID:36358852

    Open questions at the time
    • Whether the CDCA8–SNAI2 interaction occurs in non-cancer contexts is unknown
    • No structural basis for CDCA8 acting as a transcriptional co-activator
  8. 2023 Medium

    Demonstration that CDCA8 competes with PTEN for AKT binding, stabilizing HIF1α via AKT/GSK3β signaling with a HIF1α-to-CDCA8 transcriptional feedback loop, provided a mechanistic basis for CDCA8's role in hypoxia adaptation.

    Evidence Co-IP for CDCA8–AKT interaction, PTEN competition assays, promoter reporter for HIF1α binding CDCA8 promoter in bladder cancer

    PMID:37813876

    Open questions at the time
    • Stoichiometric parameters of the PTEN–CDCA8 competition for AKT not defined
    • Feedback loop not validated outside bladder cancer
  9. 2023 Medium

    CDCA8 haploinsufficiency in mice caused thyroid developmental defects and late-onset papillary-like tumors with ERK activation, establishing an in vivo tumor-suppressive dosage effect for a CPC component.

    Evidence Heterozygous mouse knockout, histology, transcriptomics, comparison with human thyroid tumor tissue

    PMID:37964961

    Open questions at the time
    • Whether tumor formation is due to CPC dysfunction or non-CPC CDCA8 functions is unclear
    • Mechanism connecting partial CDCA8 loss to ERK activation not elucidated
  10. 2023 Medium

    USP35 was identified as a deubiquitinase that directly stabilizes CDCA8 protein by removing ubiquitin, establishing the first post-translational mechanism controlling CDCA8 turnover.

    Evidence Co-IP, ubiquitination assay, cycloheximide chase in NSCLC cells

    PMID:42002994

    Open questions at the time
    • The E3 ubiquitin ligase targeting CDCA8 for degradation is not identified
    • Whether USP35-mediated stabilization is cell-cycle-regulated is unknown
  11. 2026 Medium

    Identification of m6A modification on the CDCA8 3′UTR recognized by YTHDF3, which recruits eIF3A to promote CDCA8 translation, established an epitranscriptomic layer of CDCA8 regulation and linked it to chemotherapy sensitivity through spindle integrity.

    Evidence m6A mapping, YTHDF3 Co-IP, eIF3A interaction assays, multipolar spindle imaging, chemosensitivity assays

    PMID:41565643

    Open questions at the time
    • Writers and erasers responsible for CDCA8 m6A marks not identified
    • Whether m6A regulation of CDCA8 is cell-cycle-dependent is unknown
  12. 2026 Medium

    HAUS1 was shown to recruit E2F1 to the CDCA8 promoter via physical interaction with EZH2 in a methylation-independent manner, revealing a second upstream effector converging on the EZH2–E2F1 axis.

    Evidence Co-IP, ChIP-qPCR at CDCA8 promoter, transcriptomic profiling, rescue experiments in colorectal cancer

    PMID:41546483

    Open questions at the time
    • Whether HAUS1 and EZH2 form a stable complex or interact transiently is unknown
    • Relationship between HAUS1's augmin complex role and its transcriptional function not clarified

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the identity of the E3 ligase targeting CDCA8, the structural basis for CDCA8's non-CPC transcriptional functions, and whether the diverse cancer-associated signaling roles (AKT, ERK, HIF1α, CDK1) reflect direct molecular interactions or indirect consequences of mitotic perturbation.
  • E3 ubiquitin ligase for CDCA8 not identified
  • No structural model of CDCA8 in transcriptional complexes (e.g., SNAI2, E2F1)
  • Discrimination between direct signaling roles and secondary effects of CPC/mitotic disruption lacking

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 2 GO:0140110 transcription regulator activity 1
Localization
GO:0005634 nucleus 2 GO:0005694 chromosome 2 GO:0005856 cytoskeleton 2
Pathway
R-HSA-1640170 Cell Cycle 4 R-HSA-162582 Signal Transduction 3 R-HSA-74160 Gene expression (Transcription) 3
Partners
AKT1E2F1EZH2NF-YASNAI2TMED3USP35YTHDF3
Complex memberships
CDCA8/SNAI2 transcriptional complexChromosomal Passenger Complex (CPC)

Evidence

Reading pass · 19 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 CDCA8 (Borealin/DasraB) is an essential component of the Chromosomal Passenger Complex (CPC) required for proper chromosome segregation during mitosis; knockout mice die by embryonic day 5.5 due to mitotic defects, microtubule disorganization, loss of CPC enrichment at centromeres, and p53-independent apoptosis in blastocyst cells. Targeted gene disruption in mice (knockout), immunofluorescence microscopy, p53 double-knockout epistasis Mechanisms of development High 18337066
2020 CDCA8 protein dynamically localizes during human oocyte meiosis (from GVBD to MII) and is required for bipolar spindle assembly and proper chromosome segregation; CDCA8 RNAi in GV-stage oocytes causes multipolar spindles, disordered chromosomes, and impaired microtubule assembly without affecting GVBD or polar body extrusion rates but extending the time to polar body extrusion. RNAi knockdown in human oocytes, immunofluorescence localization, live-cell imaging of meiotic progression Gene Medium 32088244
2015 CDCA8 transcription is activated by transcription factor NF-Y binding to its promoter; NF-YA (short isoform in hESCs, long isoform in cancer cells) binds the CDCA8 basic promoter, and NF-Y overexpression enhances while NF-Y knockdown reduces CDCA8 transcription. CREB1 binding to a second element also activates the promoter. Reporter gene assays, electrophoretic mobility shift assay (EMSA), NF-Y overexpression/knockdown, promoter mutation analyses, transgenic mouse reporter The Journal of biological chemistry High 26170459
2021 CDCA8 silencing in hepatocellular carcinoma cells causes G2/M arrest with decreased cyclin B1 and p-cdc2 levels, upregulates tumor-suppressive ATF3 and GADD34 at the protein level, and inactivates AKT/β-catenin signaling, reducing CD133+ cancer stem cell sphere-forming capacity and tumor growth in a xenograft model. siRNA knockdown, flow cytometry cell cycle analysis, western blot, RNA sequencing, xenograft mouse model Cancers Medium 33801424
2023 CDCA8 knockdown in hepatocellular carcinoma suppresses the MEK/ERK pathway and downregulates TPM3, NECAP2, and USP13; NF-YA overexpression upregulates CDCA8 and CDCA8 knockdown attenuates NF-YA-mediated cell invasion. RNA sequencing, western blot, qRT-PCR, in vitro proliferation/migration/invasion assays, orthotopic and tail vein tumor models Experimental hematology & oncology Medium 36639822
2019 KIF18B binds to the CDCA8 promoter region and activates CDCA8 transcription, promoting pancreatic ductal adenocarcinoma cell proliferation; KIF18B knockdown reduces CDCA8 expression and arrests the cell cycle. ChIP assay (KIF18B binding to CDCA8 promoter), qRT-PCR, cell proliferation assays, cell cycle analysis, in vivo xenograft Journal of cellular physiology Medium 31875977
2022 EZH2 activates CDCA8 expression in prostate cancer through two mechanisms: (1) methyltransferase-dependent H3K27me3 repression of let-7b miRNA, which otherwise targets CDCA8 transcripts, and (2) methyltransferase-independent recruitment of E2F1 to its own promoter, increasing E2F1 levels that then transcriptionally activate CDCA8 and other CPC subunits. Genome-wide ChIP-seq, RNA-seq, miRNA profiling, let-7b reporter assays, EZH2 catalytic mutant analysis Oncogene High 35094010
2022 CDCA8 forms a complex with SNAI2 (CDCA8/SNAI2 complex) that binds the CD44 promoter to transcriptionally activate CD44 expression, promoting proliferation and invasion of pancreatic ductal adenocarcinoma. Co-immunoprecipitation (Co-IP), ChIP-qPCR, dual-luciferase reporter assay, in vitro and in vivo invasion/proliferation assays Cancers Medium 36358852
2023 CDCA8 stabilizes HIF1α protein in bladder cancer by competing with PTEN for AKT binding, displacing PTEN and activating the AKT/GSK3β signaling cascade that prevents HIF1α degradation; in turn, HIF1α binds the CDCA8 promoter to transcriptionally activate CDCA8, forming a positive-feedback loop. Co-immunoprecipitation, western blot, promoter reporter assay, PTEN/AKT manipulation, hypoxia cell survival assays Cell death & disease Medium 37813876
2022 CDCA8 contributes to thyroid cancer progression via regulation of CDK1; CDCA8 knockdown reduces CDK1 levels, and CDK1 overexpression partially rescues the tumor-suppressive effect of CDCA8 knockdown, placing CDK1 downstream of CDCA8 in thyroid cancer cells. shRNA knockdown, CDK1 overexpression rescue, in vitro proliferation/colony formation/apoptosis assays, in vivo xenograft Journal of Cancer Medium 35517403
2021 CDCA8 silencing in ovarian cancer sensitizes cells to PARP inhibitor olaparib and cisplatin by inducing G2/M arrest, increasing DNA damage, and interfering with RAD51 accumulation at DNA damage foci; MYBL2 was identified as an upstream transcription factor positively regulating CDCA8 expression. siRNA knockdown, flow cytometry, comet assay/DNA damage foci analysis, RAD51 immunofluorescence, ChIP for MYBL2 binding American journal of cancer research Medium 33575078
2021 CDCA8 synergizes with E2F1 to promote glioma cell proliferation and migration; double targeting of both CDCA8 and E2F1 additively inhibits glioma growth, and gene microarray identified E2F1 as a CDCA8-synergetic protein. siRNA/shRNA knockdown, gene microarray, in vitro proliferation/migration/apoptosis assays, in vivo xenograft Cell death & disease Low 33542211
2023 TMED3 interacts with CDCA8 (demonstrated by Co-IP), and CDCA8 acts downstream of TMED3 to activate the PI3K/AKT pathway in melanoma; CDCA8 overexpression rescues the inhibitory effects of TMED3 knockdown, and SC79 (AKT activator) rescues the effects of CDCA8 depletion, placing CDCA8 between TMED3 and PI3K/AKT signaling. Co-immunoprecipitation, rescue overexpression experiments, western blot for P-Akt/P-PI3K, in vitro and in vivo functional assays Cell & bioscience Medium 36991473
2023 USP35 directly interacts with CDCA8 (by Co-IP) and deubiquitinates it, preventing proteasomal degradation and stabilizing CDCA8 protein levels in non-small cell lung cancer cells, thereby promoting tumor aggressiveness. Co-immunoprecipitation, IP-western blot for ubiquitination, cycloheximide chase assay, siRNA knockdown Combinatorial chemistry & high throughput screening Medium 42002994
2026 HAUS1 physically interacts with EZH2 and recruits E2F1 to the CDCA8 promoter in a methylation-independent manner, transcriptionally activating CDCA8; CDCA8 disruption abrogates the oncogenic effects of HAUS1 overexpression in colorectal cancer. Co-immunoprecipitation, ChIP-qPCR, transcriptomic profiling, rescue experiments, in vivo xenograft FASEB journal Medium 41546483
2026 The 5'UTR of INCENP and the 3'UTR of CDCA8 undergo m6A methylation; YTHDF3 recognizes these m6A sites and facilitates translation of INCENP and CDCA8 through interaction with eIF3A; inhibition of INCENP and CDCA8 enhances neoadjuvant chemotherapy sensitivity by promoting multipolar spindle formation. m6A methylation mapping, YTHDF3 Co-IP, eIF3A interaction assays, multipolar spindle imaging, in vitro/in vivo chemotherapy sensitivity assays Nature communications Medium 41565643
2023 CDCA8 (Borealin) haploinsufficiency in mice alters thyroid development, causing hyperplastic anlage at E9.5, thyroid hypoplasia from E11.5, and in aged mice, papillary-like thyroid tumor structures associated with ERK pathway activation and elevated Braf-like gene expression; CDCA8 mutations also decrease thyrocyte adhesion and migration. Heterozygous mouse knockout, histology, transcriptomic analysis, qPCR, comparison with human patient tumor tissue Frontiers in endocrinology Medium 37964961
2023 The 1-kb human CDCA8 promoter directs expression specifically to GFRA1+ undifferentiated spermatogonia along the basement membrane in adult testes, as demonstrated by transgenic luciferase reporter mice. Transgenic mouse model with luciferase reporter, in vivo imaging, immunohistochemistry, immunofluorescence co-staining with GFRA1 Gene Medium 36898512
2024 MYBL2 acts as an upstream transcription factor that positively regulates CDCA8 expression in malignant melanoma; MYBL2 knockdown decreases CDCA8 gene and protein expression and reduces tumor growth in vivo, while CDCA8 overexpression rescues migration and invasion impaired by MYBL2 knockdown. qPCR, western blot, migration/invasion assays, xenograft in vivo model, MYBL2 OE/KD with CDCA8 rescue Heliyon Low 38961953

Source papers

Stage 0 corpus · 83 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1997 A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family. Nature genetics 513 9020840
1997 Clustering of mutations responsible for branchio-oto-renal (BOR) syndrome in the eyes absent homologous region (eyaHR) of EYA1. Human molecular genetics 178 9361030
1978 Genetic aspects of the BOR syndrome--branchial fistulas, ear pits, hearing loss, and renal anomalies. American journal of medical genetics 139 263442
1987 Complete amino acid sequences of variable regions of two human IgM rheumatoid factors, BOR and KAS of the Wa idiotypic family, reveal restricted use of heavy and light chain variable and joining region gene segments. The Journal of experimental medicine 133 2439644
1997 BOR and BO syndromes are allelic defects of EYA1. European journal of human genetics : EJHG 124 9359046
2013 Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome. Nature structural & molecular biology 96 23435380
1994 A proposed new contiguous gene syndrome on 8q consists of Branchio-Oto-Renal (BOR) syndrome, Duane syndrome, a dominant form of hydrocephalus and trapeze aplasia; implications for the mapping of the BOR gene. Human molecular genetics 96 7849713
2004 Diversity and abundance of Bacteria and Archaea in the Bor Khlueng Hot Spring in Thailand. Journal of basic microbiology 88 15558824
2001 Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome. Human molecular genetics 86 11734542
1995 bor gene of phage lambda, involved in serum resistance, encodes a widely conserved outer membrane lipoprotein. Journal of bacteriology 84 7868598
1998 Eya1 expression in the developing ear and kidney: towards the understanding of the pathogenesis of Branchio-Oto-Renal (BOR) syndrome. Developmental dynamics : an official publication of the American Association of Anatomists 82 9853969
2008 Branchio-oto-renal syndrome (BOR): novel mutations in the EYA1 gene, and a review of the mutational genetics of BOR. Human mutation 78 18220287
2018 Distinct expression of CDCA3, CDCA5, and CDCA8 leads to shorter relapse free survival in breast cancer patient. Oncotarget 76 29467944
2008 SIX1 mutation screening in 247 branchio-oto-renal syndrome families: a recurrent missense mutation associated with BOR. Human mutation 71 18330911
1999 Inner ear and kidney anomalies caused by IAP insertion in an intron of the Eya1 gene in a mouse model of BOR syndrome. Human molecular genetics 67 10072433
2015 Transcriptional activation of human CDCA8 gene regulated by transcription factor NF-Y in embryonic stem cells and cancer cells. The Journal of biological chemistry 60 26170459
2001 Oto-facio-cervical (OFC) syndrome is a contiguous gene deletion syndrome involving EYA1: molecular analysis confirms allelism with BOR syndrome and further narrows the Duane syndrome critical region to 1 cM. Human genetics 51 11409867
2021 Silencing CDCA8 Suppresses Hepatocellular Carcinoma Growth and Stemness via Restoration of ATF3 Tumor Suppressor and Inactivation of AKT/β-Catenin Signaling. Cancers 49 33801424
1998 Autosomal-dominant branchio-otic (BO) syndrome is not allelic to the branchio-oto-renal (BOR) gene at 8q13. American journal of medical genetics 41 9556298
2019 CDCA8 is a key mediator of estrogen-stimulated cell proliferation in breast cancer cells. Gene 39 30953709
2002 Genomic rearrangements of EYA1 account for a large fraction of families with BOR syndrome. European journal of human genetics : EJHG 39 12404110
2018 CDCA8 expression and its clinical relevance in patients with bladder cancer. Medicine 38 30142792
2013 Mutational analysis of EYA1, SIX1 and SIX5 genes and strategies for management of hearing loss in patients with BOR/BO syndrome. PloS one 34 23840632
2021 CDCA8, targeted by MYBL2, promotes malignant progression and olaparib insensitivity in ovarian cancer. American journal of cancer research 33 33575078
2015 Expression of CDCA8 correlates closely with FOXM1 in breast cancer: public microarray data analysis and immunohistochemical study. Neoplasma 31 25866227
1998 Description of a large kindred with autosomal dominant inheritance of branchial arch anomalies, hearing loss, and ear pits, and exclusion of the branchio-oto-renal (BOR) syndrome gene locus (chromosome 8q13.3). American journal of medical genetics 31 9788564
2023 CDCA8 induced by NF-YA promotes hepatocellular carcinoma progression by regulating the MEK/ERK pathway. Experimental hematology & oncology 30 36639822
2013 Branchio-Oto-Renal Syndrome (BOR) associated with focal glomerulosclerosis in a patient with a novel EYA1 splice site mutation. BMC nephrology 30 23506628
2019 KIF18B promotes the proliferation of pancreatic ductal adenocarcinoma via activating the expression of CDCA8. Journal of cellular physiology 29 31875977
2008 Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality. Mechanisms of development 28 18337066
2021 Double-targeting CDCA8 and E2F1 inhibits the growth and migration of malignant glioma. Cell death & disease 26 33542211
2020 Knockdown of CDCA8 inhibits the proliferation and enhances the apoptosis of bladder cancer cells. PeerJ 24 32377458
2006 EYA1 and SIX1 gene mutations in Japanese patients with branchio-oto-renal (BOR) syndrome and related conditions. Pediatric nephrology (Berlin, Germany) 23 16491411
1999 New' manifestations of BOR syndrome. Clinical genetics 23 10636449
2022 Methylation-dependent and -independent roles of EZH2 synergize in CDCA8 activation in prostate cancer. Oncogene 22 35094010
2021 miR-133b inhibits cell proliferation, migration, and invasion of lung adenocarcinoma by targeting CDCA8. Pathology, research and practice 22 33971546
2007 Detection of Iss and Bor on the surface of Escherichia coli. Journal of applied microbiology 22 17309614
1996 Detection of a megabase deletion in a patient with branchio-oto-renal syndrome (BOR) and tricho-rhino-phalangeal syndrome (TRPS): implications for mapping and cloning the BOR gene. Genomics 21 8824802
2020 CDCA8 regulates meiotic spindle assembly and chromosome segregation during human oocyte meiosis. Gene 20 32088244
2018 Molecular characterization of the genome-wide BOR transporter gene family and genetic analysis of BnaC04.BOR1;1c in Brassica napus. BMC plant biology 20 30217178
2005 Chromosome-borne class A BOR-1 beta-Lactamase of Bordetella bronchiseptica and Bordetella parapertussis. Antimicrobial agents and chemotherapy 20 15917575
2016 Biochemical parameters of Spodoptera frugiperda (J. E. Smith) treated with citronella oil (Cymbopogon winterianus Jowitt ex Bor) and its influence on reproduction. Acta histochemica 19 27012436
2006 Characterization of a novel cyclomaltodextrinase expressed from environmental DNA isolated from Bor Khleung hot spring in Thailand. FEMS microbiology letters 19 16790023
2014 BOR-syndrome-associated Eya1 mutations lead to enhanced proteasomal degradation of Eya1 protein. PloS one 18 24489909
2020 Identification of CDCA8, DSN1 and BIRC5 in Regulating Cell Cycle and Apoptosis in Osteosarcoma Using Bioinformatics and Cell Biology. Technology in cancer research & treatment 17 33153400
2005 Identification of a novel mutation in the EYA1 gene in a Korean family with branchio-oto-renal (BOR) syndrome. International journal of pediatric otorhinolaryngology 17 16005355
1994 Localization of branchio-oto-renal (BOR) syndrome to a 3 Mb region of chromosome 8q. American journal of medical genetics 15 8092198
2022 MiR-133a-3p inhibits the malignant progression of oesophageal cancer by targeting CDCA8. Journal of biochemistry 14 34117764
2022 Molecular Characterization, Evolutionary Analysis, and Expression Profiling of BOR Genes in Important Cereals. Plants (Basel, Switzerland) 13 35406892
2022 CDCA8 Contributes to the Development and Progression of Thyroid Cancer through Regulating CDK1. Journal of Cancer 13 35517403
2020 Antimicrobial activities and mechanism of action of Cymbopogon khasianus (Munro ex Hackel) Bor essential oil. BMC complementary medicine and therapies 12 33153473
2023 CDCA8 promotes bladder cancer survival by stabilizing HIF1α expression under hypoxia. Cell death & disease 11 37813876
2021 Mutations in SIX1 Associated with Branchio-oto-Renal Syndrome (BOR) Differentially Affect Otic Expression of Putative Target Genes. Journal of developmental biology 11 34208995
2003 Effect of compound rhodiola sachalinensis A Bor on CCl4-induced liver fibrosis in rats and its probable molecular mechanisms. World journal of gastroenterology 11 12854163
2017 Effects of citronella oil (Cymbopogon winterianus Jowitt ex Bor) on Spodoptera frugiperda (J. E. Smith) midgut and fat body. Biotechnic & histochemistry : official publication of the Biological Stain Commission 10 29205073
2023 TMED3 promotes the development of malignant melanoma by targeting CDCA8 and regulating PI3K/Akt pathway. Cell & bioscience 9 36991473
2022 CDCA8/SNAI2 Complex Activates CD44 to Promote Proliferation and Invasion of Pancreatic Ductal Adenocarcinoma. Cancers 9 36358852
2022 Upregulation of KIF18B facilitates malignant phenotype of esophageal squamous cell carcinoma by activating CDCA8/mTORC1 pathway. Journal of clinical laboratory analysis 8 36085568
2006 Identification of two major loci that suppress hearing loss and cochlear dysmorphogenesis in Eya1bor/bor mice. Genomics 8 16488112
2021 Population genetic structure and evolutionary history of Psammochloa villosa (Trin.) Bor (Poaceae) revealed by AFLP marker. Ecology and evolution 7 34367573
2014 Identification of a novel nonsynonymous mutation of EYA1 disrupting splice site in a Korean patient with BOR syndrome. Molecular biology reports 7 24590738
2023 Let-7c-5p down-regulates immune-related CDCA8 to inhibit hepatocellular carcinoma. Functional & integrative genomics 6 36737507
2023 BUB1, BUB1B, CCNA2, and CDCA8, along with miR-524-5p, as clinically relevant biomarkers for the diagnosis and treatment of endometrial carcinoma. BMC cancer 5 37853361
2023 Using Xenopus to discover new candidate genes involved in BOR and other congenital hearing loss syndromes. Journal of experimental zoology. Part B, Molecular and developmental evolution 4 37830236
2023 Borealin/CDCA8 deficiency alters thyroid development and results in papillary tumor-like structures. Frontiers in endocrinology 4 37964961
2022 Molecular characterization of the genome-wide BOR transporter family and their responses to boron conditions in common wheat (Triticum aestivum L.). Frontiers in plant science 4 36275596
2008 Mapping of genetic modifiers of Eya1 ( bor/bor ) in CAST/EiJ and BALB/cJ that suppress cochlear aplasia and associated deafness. Mammalian genome : official journal of the International Mammalian Genome Society 3 18836772
2025 CDCA8 and its multifaceted role in tumorigenesis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2 40056827
2024 Boron homeostasis affects Longan yield: a study of NIP and BOR boron transporter of two cultivars. BMC plant biology 2 38163908
2024 MiR-490-3p promotes cell apoptosis and cell-cycle arrest in osteosarcoma via the modulation of CDCA8/ATF3 by targeting NUSAP1. Translational pediatrics 2 39823004
2006 What's so Bor(a)ing about Aurora-A activation? Developmental cell 2 16890151
2026 TMEM106C, BSG, COPE, CDCA8, KPNA2, LIG1, UQCRH, and CCT5: Predictive of Survival and Immunotherapy Resistance in Hepatocellular Carcinoma. Human mutation 1 41674779
2023 A 1-kb human CDCA8 promoter directs the spermatogonia-specific luciferase expression in adult testis. Gene 1 36898512
2017 [Establishment of BOR-Resistant U266 Cell Line and the Detection of Its Biological Activities]. Zhongguo shi yan xue ye xue za zhi 1 29262905
2026 HAUS1 Promotes Colorectal Cancer Progression by Activating CDCA8 Transcription Through the HAUS1-EZH2-E2F1 Axis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 0 41546483
2026 INCENP and CDCA8 predict neoadjuvant chemotherapy response and outcomes in esophageal squamous cell carcinoma. Nature communications 0 41565643
2026 USP35 Acts as a Dual Stabilizer of CDCA8 and PD-L1 to Coordinate the Progression and Immune Evasion in Non-Small Cell Lung Cancer. Combinatorial chemistry & high throughput screening 0 42002994
2025 Unveiling the Genome of the Diploid Wild Sugarcane Relative Narenga porphyrocoma (Hance) Bor. International journal of molecular sciences 0 40649902
2025 Suppressing CDCA8/CDK1 improves oral squamous cell carcinoma by modulating proliferation, apoptosis, cell cycle and migration. Discover oncology 0 41091302
2025 A core stemness-associated module reveals PLK1, NUF2, KIF23, CDCA8, TOP2A, CENPF, AURKA, and ASPM as key genes in rectal cancer. European journal of medical research 0 41373021
2024 The correlation between the MYBL2/CDCA8 signaling pathway of malignant melanoma. Heliyon 0 38961953
2024 Amoebicidal activity of essential oils and essential oil-based microemulsions of Aloysia citrodora Ortega ex Pers., Cymbopogon winterianus Jowitt ex Bor, and Ocimum gratissimum L. against Acanthamoeba polyphaga trophozoites. Journal of applied microbiology 0 39237458
2019 Phylogenetic Analysis of bor Gene in an Escherichia coli Strain 1378 (O78:K80) Isolated from an Avian Colibacillosis Case in Tehran, Iran. Archives of Razi Institute 0 31592597