Affinage

SCD

Stearoyl-CoA desaturase · UniProt O00767

Length
359 aa
Mass
41.5 kDa
Annotated
2026-06-10
100 papers in source corpus 38 papers cited in narrative 38 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

SCD (stearoyl-CoA desaturase 1) is an endoplasmic reticulum-resident enzyme that catalyzes the rate-limiting Δ9-desaturation of saturated fatty acids into monounsaturated fatty acids (MUFAs), a reaction central to de novo lipogenesis and fat cell metabolism (PMID:7480063, PMID:35718096). Its principal products—oleate and palmitoleate—act not only as building blocks for membrane and storage lipids but as signaling intermediates: oleate drives SREBP-1 nuclear accumulation to sustain lipogenesis (PMID:28851735), modulates the AMP/ATP ratio to control AMPK→SIRT1→histone acetylation (PMID:31241768), and the specific phospholipid PI(18:1/18:1) suppresses p38 MAPK, the unfolded protein response, and apoptosis while regulating autophagy (PMID:35624087). By converting saturated very-long-chain and palmitoyl/stearoyl species to MUFAs, SCD limits ER stress, NF-κB-driven inflammation, and ceramide accumulation across endothelium, sebocytes, intestine, and disease models (PMID:33690217, PMID:33612070, PMID:38354249, PMID:36843338), and supports autophagosome–lysosome fusion required for adipocyte viability (PMID:38492843). A recurrent theme is SCD's protection against ferroptosis: by enriching cells in anti-peroxidative MUFAs and influencing cholesterol and SLC7A11 metabolism, it confers resistance to ferroptosis inducers and chemotherapy in multiple cancers (PMID:33296645, PMID:36109580, PMID:38972654, PMID:40198901, PMID:37002201). SCD is heavily controlled at multiple regulatory layers—transcriptionally by MITF, HNF4A, ChREBP, HBXIP-ZNF263, and Nodal/Smad2/3 (PMID:31733993, PMID:34171462, PMID:33840688, PMID:36109580, PMID:37002201), and post-transcriptionally through ADAR1-KHDRBS1 RNA editing and several m6A writer–reader systems (METTL14-YTHDF2, METTL16-YTHDC2, METTL3-YTHDF1) that tune SCD mRNA stability (PMID:37208334, PMID:37592151, PMID:38334797, PMID:39903889). In cancer SCD frequently promotes invasion, stemness, and immune evasion—membrane-fluidity-dependent invasion under matrix stiffness (PMID:35358687), suppression of CD8+ T cell effector function via oleate/ACAT1 (PMID:37879607), and stem-cell self-renewal (PMID:37208334)—though its dispensability can be masked by paralog SCD2 compensation (PMID:24069385). Pharmacological SCD1 inhibition is contextually linked to motor phenotypes in adrenoleukodystrophy and cardiac, renal, and inflammatory disease models (PMID:33690217, PMID:34576047, PMID:39832629).

Mechanistic history

Synthesis pass · year-by-year structured walk · 17 steps
  1. 1995 High

    Established SCD1 as the rate-limiting desaturase converting saturated fatty acids to MUFAs, defining its core enzymatic role in lipogenesis and fat metabolism.

    Evidence Review synthesizing biochemical and molecular studies of the SCD gene family

    PMID:7480063

    Open questions at the time
    • Does not resolve isoform/paralog-specific substrate preferences in vivo
    • No structural mechanism of catalysis provided
  2. 2013 High

    Showed SCD1 is genetically dispensable for AKT/Ras-driven hepatocarcinogenesis because paralog SCD2 compensates, defining when targeting SCD1 alone fails.

    Evidence SCD1 knockout mice with AKT/Ras hydrodynamic injection plus siRNA co-silencing of SCD1/SCD2

    PMID:24069385

    Open questions at the time
    • Tissue/tumor contexts where SCD2 compensation does not occur not delineated
    • No combined pharmacological dual-inhibitor validation in vivo
  3. 2017 High

    Identified the SCD1 product oleate as the signal that restores SREBP-1 nuclear accumulation and lipogenesis, linking enzyme output to a transcriptional feed-forward loop.

    Evidence Scd1-deficient and liver-specific oleate/palmitoleate transgenic mice with hepatocyte SREBP-1 assays

    PMID:28851735

    Open questions at the time
    • Molecular mechanism by which oleate promotes SREBP-1 processing unresolved
    • Relative contribution of oleate vs palmitoleate not separated
  4. 2019 High

    Connected SCD1 activity to cellular energy state, showing it controls AMP/ATP ratio, AMPK, NAD+/SIRT1, and histone acetylation in muscle.

    Evidence SCD1 knockout and muscle-specific overexpression mice with metabolic and epigenetic readouts

    PMID:31241768

    Open questions at the time
    • Direct biochemical link between MUFA levels and AMP generation not defined
    • Generality beyond skeletal muscle unclear
  5. 2019 High

    Defined a lineage-restricted MITF-SCD transcriptional axis required for MITFHigh melanoma proliferation, establishing context-dependent SCD dependency.

    Evidence Genetic/pharmacological SCD perturbation with MITF modulation, proliferation/invasion and in vivo metastasis assays

    PMID:31733993

    Open questions at the time
    • Direct MITF binding to SCD promoter not detailed
    • Mechanism of MITFLow insensitivity unresolved
  6. 2021 High

    Identified the specific SCD1-derived lipokine PI(18:1/18:1) as a suppressor of p38/UPR/apoptosis and regulator of autophagy and PP2A, elevating SCD1 from metabolic enzyme to signaling hub.

    Evidence Lipidomics, Scd1-defective mice, exogenous PI(18:1/18:1) supplementation, p38/UPR/PP2A assays across cell lines and tissues

    PMID:35624087

    Open questions at the time
    • Direct molecular target/receptor of PI(18:1/18:1) not identified
    • How PI(18:1/18:1) represses PP2A mechanistically unclear
  7. 2021 High

    Demonstrated that SCD1-mediated shift from saturated to monounsaturated VLCFAs reduces ER stress, linking SCD1 to adrenoleukodystrophy pathology.

    Evidence Zebrafish ALD drug screen and CRISPR scd1 knockout, LXR agonists in Abcd1-/y mice, ALD fibroblast ER stress and lipidomics

    PMID:33690217

    Open questions at the time
    • Whether SCD1 modulation is therapeutic in human ALD not established
    • Mechanism of VLCFA recognition by SCD1 not defined
  8. 2021 Medium

    Linked SCD1 to multiple upstream metabolic and transcriptional regulators (ACO2 citrate flux, HNF4A binding, ChREBP/histone acetylation), building the input map for SCD1 expression.

    Evidence ACO2 perturbation with isotope tracing; HNF4A ChIP/knockdown/reporter with SNP analysis; ChREBP/histone ChIP in fructose-fed rats

    PMID:33676027 PMID:33840688 PMID:34171462

    Open questions at the time
    • Cross-tissue generality of each regulatory input not tested
    • Interplay among these regulators on the SCD1 locus unresolved
  9. 2020 Medium

    Established SCD1 as a downstream effector protecting cancer cells from ferroptosis via MUFA production, regulated by lactate/MCT1-AMPK-SREBP1 and FBW7-NR4A1 axes.

    Evidence MCT1 and FBW7/NR4A1 perturbation, AMPK/SREBP1 modulation, ferroptosis assays in vitro and in xenografts

    PMID:33271455 PMID:33296645

    Open questions at the time
    • Direct promoter/binding evidence for FBW7-NR4A1-SCD1 lacking
    • Quantitative contribution of SCD1 vs other anti-ferroptotic factors unclear
  10. 2022 Medium

    Showed SCD1 is mechanoresponsive and promotes invasion by remodeling membrane fluidity, while also reprogramming the antitumor immune microenvironment.

    Evidence Mechanotunable substrate culture, lipidomics, genetic/pharmacological SCD1 manipulation with oleic acid rescue, plus tumor immune models (CCL4, DC/CD8 assays, anti-PD-1)

    PMID:35358687 PMID:35793868 PMID:37879607

    Open questions at the time
    • Mechanism converting membrane fluidity to invasion signaling not defined
    • Direct sensor coupling matrix stiffness to SCD1 transcription unknown
  11. 2022 High

    Extended SCD1's protective MUFA function to tissue physiology—hemidesmosome/integrin α6β4 integrity in keratinocytes, cardiac lipotoxicity on overexpression, and gut-liver lipid crosstalk.

    Evidence Keratinocyte-specific Scd1 KO with PI3K-inhibitor and oleate rescue; cardiac-specific SCD transgenic mice; intestine-specific SCD1 KO with lipidomics

    PMID:34576047 PMID:35718096 PMID:36507562

    Open questions at the time
    • Mechanism linking MUFA supply to integrin complex stability unresolved
    • AT1 receptor upregulation mechanism in cardiac overexpression not defined
  12. 2022 Medium

    Identified protein-level and microenvironmental regulators of SCD1 (HBXIP-ZNF263 transcription, pH-dependent SCD1-PPARα binding), expanding its regulatory inputs.

    Evidence HBXIP/ZNF263 coactivation assays with ferroptosis readouts; proteomics and pH-dependent SCD1-PPARα co-IP with PI3K/AKT inhibitors

    PMID:35046108 PMID:36109580

    Open questions at the time
    • Functional consequence of SCD1-PPARα interaction not mechanistically resolved
    • Single co-IP basis for the SCD1-PPARα interaction
  13. 2023 Medium

    Defined post-transcriptional control of SCD1 by ADAR1 A-to-I editing recruiting KHDRBS1, and AKAP8L/IGF2BP1, that stabilize SCD1 mRNA to drive cancer stemness and chemoresistance.

    Evidence Patient-derived organoids, RNA editing and RIP assays, mRNA stability assays, co-IP, with SCD1 inhibition

    PMID:36522343 PMID:37208334

    Open questions at the time
    • Whether editing and m6A pathways converge on the same transcripts unknown
    • AKAP8L-IGF2BP1-SCD1 axis from single lab without reciprocal validation
  14. 2023 Medium

    Established m6A writer-reader control of SCD1 mRNA stability (METTL14-YTHDF2) and SCD1's downstream control of SQLE/cholesterol and Wnt/β-catenin in cancer stemness and ferroptosis.

    Evidence MeRIP/RIP, mRNA decay assays, SQLE promoter and P53 binding analysis, Nodal/Smad2/3 reporter, ferroptosis assays

    PMID:37002201 PMID:37592151 PMID:38972654

    Open questions at the time
    • Cell-type specificity of opposing m6A reader outcomes unresolved
    • Direct vs indirect SCD1 control of SQLE transcription not fully separated
  15. 2024 High

    Broadened SCD1's physiological roles—endothelial anti-inflammatory protection during exercise, adipocyte autophagy/lysosomal function, and cardiac reprogramming—through MUFA-dependent mechanisms.

    Evidence Endothelial-specific Scd1 KO with adenoviral rescue and single-cell transcriptomics; Scd1 KO adipocytes with MUFA rescue and autophagy flux; cardiac fibroblast Scd1 knockdown with metabolic flux modeling

    PMID:38354249 PMID:38492843 PMID:40007118

    Open questions at the time
    • Mechanism by which MUFAs support lysosomal acidification unresolved
    • Generalizability of endothelial findings beyond Ldlr-/- model untested
  16. 2024 Medium

    Connected SCD1 inhibition to innate immune and ferroptotic stress pathways (cGAS/STING, AKT-GSK3β-NRF2-SLC7A11) and identified direct SCD1-binding modulators (RIFSP-2, SULT2B1).

    Evidence SCD1 inhibitors with transcriptomics/lipidomics/kinase arrays, cGAS/STING markers, biotin pull-down and co-IP, in vivo tumor/fibrosis/irradiation models

    PMID:38372484 PMID:38582510 PMID:39832629 PMID:40198901

    Open questions at the time
    • Direct molecular events linking MUFA loss to STING activation not defined
    • SCD1-SULT2B1 interaction from single co-IP without structural detail
  17. 2024 Medium

    Resolved additional m6A regulatory systems controlling SCD1 mRNA (METTL16-YTHDC2, METTL3-YTHDF1, IGF2BP3-METTL14), showing layered and tissue-specific tuning of SCD1 in cancer and NAFLD.

    Evidence Gain/loss-of-function of m6A enzymes, m6A abundance and reader RIP assays, RNA decay assays, H3K18lac/promoter analysis, in vivo models

    PMID:38334797 PMID:38355626 PMID:39903889

    Open questions at the time
    • Hierarchy and competition among the multiple m6A reader systems on SCD1 unknown
    • Each axis established in a single tumor context

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the diverse upstream regulators and the distinct MUFA-derived signals (PI(18:1/18:1), oleate, palmitoleate) are integrated to produce context-specific outcomes—ferroptosis resistance, invasion, immune suppression, or tissue protection—remains unresolved.
  • No unified model coupling specific lipid products to specific downstream effectors
  • Structural basis of SCD1 desaturation and substrate selectivity not addressed in corpus
  • Predictors of SCD1 dependency vs SCD2 compensation across tissues undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016491 oxidoreductase activity 3 GO:0016740 transferase activity 2
Localization
GO:0005783 endoplasmic reticulum 1
Pathway
R-HSA-5357801 Programmed Cell Death 4 R-HSA-8953854 Metabolism of RNA 4 R-HSA-1430728 Metabolism 3 R-HSA-162582 Signal Transduction 3
Partners
AKAP8LIGF2BP1KHDRBS1PPARASULT2B1

Evidence

Reading pass · 38 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 SCD1 is the key rate-limiting enzyme that catalyzes the biosynthesis of monounsaturated fatty acids (MUFAs) from saturated fatty acids, playing a central role in fat cell metabolism and de novo lipogenesis. Its expression is regulated by dietary and hormonal signals. Review of biochemical and molecular studies on SCD gene family Progress in lipid research High 7480063
2017 Oleate (an SCD1 product) specifically activates SREBP-1 nuclear accumulation and restores SREBP-1 expression and de novo lipogenesis in SCD1-deficient hepatocytes. SCD1 deficiency increases polyunsaturated fatty acid content, which in turn drives increased β-oxidation. These effects were demonstrated using Scd1-deficient mice and transgenic mice with liver-specific oleate or palmitoleate production. Scd1-deficient mice, transgenic mice (GLS5, GLS3), hepatocyte culture, SREBP-1 nuclear accumulation assay, gene expression analysis American journal of physiology. Endocrinology and metabolism High 28851735
2019 SCD1 deficiency in skeletal muscle activates AMPK through an increase in AMP levels, while muscle-specific SCD1 overexpression decreases AMPK phosphorylation and the AMP/ATP ratio. AMPK changes caused by SCD1 modulation affect NAD+ levels and consequently SIRT1 activity and histone H3K9 acetylation/methylation status. SCD1 knockout mice, muscle-specific SCD1 overexpression mice, pharmacological SCD1 inhibition, measurement of AMP/ATP ratio, AMPK phosphorylation, NAD+ levels, SIRT1 activity, histone modification Journal of cellular physiology High 31241768
2019 MITF is a lineage-restricted transcriptional activator of SCD (stearoyl-CoA desaturase) in melanoma. SCD is required for MITFHigh melanoma cell proliferation, and the MITF-SCD axis suppresses metastasis and inflammatory signaling. MITFLow cells are insensitive to SCD inhibition, demonstrating cell phenotype-dependent effects. Genetic SCD inhibition/knockdown in melanoma cells, MITF modulation, proliferation and invasion assays, in vivo metastasis models, transcriptional reporter assays Molecular cell High 31733993
2020 Lactate uptake via MCT1 promotes ATP production in hepatocellular carcinoma cells, deactivating AMPK, leading to upregulation of SREBP1 and downstream SCD1, thereby enhancing production of anti-ferroptotic monounsaturated fatty acids and conferring resistance to ferroptosis inducers RSL3 and Erastin. MCT1 inhibition/genetic knockdown, AMPK activation/inhibition, SREBP1 and SCD1 modulation, ferroptosis assays in vitro and in vivo xenograft models Cell reports High 33296645
2020 FBW7 inhibits the expression of SCD1 via inhibiting the transcription factor NR4A1 (nuclear receptor subfamily 4 group A member 1), thereby promoting ferroptosis and apoptosis in pancreatic cancer cells. Gene expression profiling, targeted metabolite analysis, genetic FBW7 overexpression/knockdown, NR4A1 and SCD1 modulation, lipid peroxidation assays Redox biology Medium 33271455
2021 SCD1-derived PI(18:1/18:1) [1,2-dioleoyl-sn-glycero-3-phospho-(1'-myo-inositol)] is a signaling lipokine that inhibits p38 MAPK activation, counteracts the unfolded protein response (UPR) and ER-associated protein degradation, regulates autophagy, and inhibits apoptosis. SCD1 expression and PI(18:1/18:1) decrease during onset of cell death, repressing PP2A and enhancing stress signaling. Lipidomics, SCD1 inhibition/deficiency (Scd1-defective mice), exogenous PI(18:1/18:1) supplementation, p38 MAPK assays, UPR markers, PP2A activity assays, multiple cell lines and mouse tissues Nature communications High 35624087
2021 In X-linked adrenoleukodystrophy (ALD), SCD1 upregulation via chloroquine or LXR agonists shifts saturated very long-chain fatty acids (VLCFAs) toward monounsaturated VLCFAs, reducing ER stress and normalizing phospholipid profiles. Pharmacological SCD1 inhibition increases saturated VLCFAs, and CRISPR knockout of scd1 in zebrafish mimics the ALD motor phenotype. Drug screen in zebrafish ALD model, SCD1 pharmacological inhibition, CRISPR scd1 knockout in zebrafish, LXR agonist treatment in Abcd1-/y mice, ALD fibroblast ER stress assays, lipidomic analysis The Journal of clinical investigation High 33690217
2021 Loss of mitochondrial aconitase (ACO2) increases citrate flux toward fatty acid synthesis and upregulates SCD1, enhancing lipid desaturation to favor colorectal cancer growth. Pharmacological SCD inhibition selectively reduces tumor formation in ACO2-deficient CRC cells. ACO2 knockdown/overexpression, metabolomics, stable isotope tracing, SCD pharmacological inhibition, tumor formation assays Molecular metabolism Medium 33676027
2021 SCD1 deficiency in SCD1-null mice results in NF-κB pathway activation, increased phosphorylated NF-κB p65 nuclear translocation, upregulation of serine palmitoyltransferase 1 (SPT1), and elevated dihydroceramide synthesis in colorectal cancer cells. Supplemental oleate counteracts SCD1-inhibition-induced NF-κB activation, confirming that reduced MUFA levels are the key mediator. SCD1 inhibitor treatment, RNA-seq, NF-κB pathway analysis, ceramide measurement, oleate supplementation rescue experiments Cancer biology & therapy Medium 33612070
2022 SCD1 is a mechanoresponsive enzyme in hepatocellular carcinoma (HCC): high matrix stiffness increases SCD1 expression, which reprograms cellular lipid composition to enhance plasma membrane fluidity and promote HCC invasion and metastasis. Exogenous oleic acid (SCD1 product) mimics the effects of high matrix stiffness, rescuing invasive migration in cells cultured on soft substrates. Polyacrylamide gel mechanotune culture system, lipidomic analysis, SCD1 genetic knockdown/overexpression, oleic acid supplementation, plasma membrane fluidity assay, in vivo metastasis models Molecular therapy High 35358687
2022 SCD1 inhibition in cancer cells reduces Wnt/β-catenin signaling, enhancing CCL4 production and promoting dendritic cell recruitment into tumors, which increases antitumor CD8+ T cell responses. In CD8+ T cells, SCD1 inhibition reduces ER stress, also enhancing CCL4 production. This dual effect synergizes with anti-PD-1 antibody therapy in mouse tumor models. SCD1 chemical inhibitor, SCD1 genetic knockout in mice, tumor models, CCL4 ELISA, DC and T cell functional assays, Wnt/β-catenin reporter assays Journal for immunotherapy of cancer Medium 35793868
2022 SCD1 inhibition in CD8+ T cells reduces oleic acid and esterified cholesterol (generated by ACAT1) levels, directly enhancing IFN-γ production and cytotoxic activity. Addition of oleic acid or cholesteryl oleate reverses the enhanced T cell functions, establishing SCD1→oleic acid→ACAT1→esterified cholesterol as the mechanistic axis suppressing T cell effector function. SCD1 inhibitor treatment of CD8+ T cells in vitro, oleic acid/cholesteryl oleate supplementation rescue, tumor-infiltrating T cell lipid analysis in vivo, ACAT1 inhibitor experiments Cancer science Medium 37879607
2022 HBXIP transcriptionally induces SCD expression by coactivating the transcription factor ZNF263, resulting in accumulation of free fatty acids that suppress ferroptosis in HCC cells and reduce sensitivity to sorafenib. HBXIP overexpression/knockdown, ZNF263 coactivation assay, SCD expression analysis, MDA and GSH measurement, ferroptosis assays in vitro and in vivo Acta pharmacologica Sinica Medium 36109580
2022 Acidic tumor microenvironment activates the PI3K/AKT signaling pathway to increase SCD1 expression in liver cancer cells. Acidification also promotes direct binding between SCD1 and PPARα, an interaction that dissipates upon pH normalization, suggesting pH-dependent modulation of SCD1-PPARα interaction controls lipid accumulation. Acidic culture conditions, proteomic analysis, PI3K/AKT pathway inhibitors, SCD1-PPARα co-immunoprecipitation under different pH conditions Molecular cancer research Medium 35046108
2022 SCD1 is an endoplasmic reticulum-membrane resident enzyme that is enriched in the distal small intestine and colon, and its intestinal-specific deletion (iKO mice) reduces not only intestinal lipids but also plasma triacylglycerols, diacylglycerols, cholesterol esters, and hepatic diacylglycerols. Intestinal SCD1 modulates hepatic de novo lipogenic gene expression via gut-liver crosstalk, potentially through production of the MUFA myristoleic acid. Intestine-specific SCD1 knockout (iKO) mice, comprehensive targeted lipidomics in intestine/liver/plasma, gene expression analysis of lipogenic genes Biochimica et biophysica acta. Molecular and cell biology of lipids High 35718096
2022 Cardiac-specific SCD overexpression (4.9-fold) in transgenic mice causes cardiac hypertrophy and heart failure with reduced ejection fraction (25.7% vs. 54.3% controls). Tg-SCD hearts show increased cardiotoxic saturated lipids (palmitate, stearate), elevated p53, and upregulation of the angiotensin II AT1 receptor. In transfected HEK cells, SCD expression increases the number of cell-surface AT1 receptor binding sites. Cardiac-specific SCD transgenic mice, echocardiography, whole-genome gene expression profiling, lipid analysis, autoradiography, fluorescence spectroscopy of fluorescent protein-labeled AT1 receptor International journal of molecular sciences High 34576047
2022 SCD1 deficiency in keratinocytes impairs integrin α6β4 complex levels and hemidesmosome (HD) assembly, allowing aberrant activation of focal adhesion kinase (FAK) and PI3K, leading to keratinocyte differentiation/proliferation and disruption of the hair follicle bulge niche. PI3K inhibition in Scd1-/- mice normalizes the bulge, hair follicle stem cells, and hair growth. Oleic acid supplementation restores HDs and hair growth. Scd1 knockout mice (keratinocyte-specific), integrin complex analysis, hemidesmosome imaging, FAK/PI3K activity assays, PI3K inhibitor rescue, oleic acid supplementation rescue Advanced science High 36507562
2023 ADAR1-mediated A-to-I RNA editing on the 3'UTR of SCD1 mRNA increases binding of the RNA-binding protein KHDRBS1, thereby augmenting SCD1 mRNA stability. Increased SCD1 facilitates lipid droplet formation, alleviates chemotherapy-induced ER stress, and enhances cancer cell self-renewal through increased β-catenin expression. Patient-derived organoid chemoresistant lines, WES + RNA-seq, A-to-I editing analysis, KHDRBS1 RIP assay, SCD1 mRNA stability assay, SCD1 pharmacological inhibition Nature communications High 37208334
2023 AKAP8L interacts with SCD1 mRNA and IGF2BP1 protein, regulating SCD1 mRNA stability in an IGF2BP1-dependent manner, thereby promoting gastric cancer cell stemness and chemoresistance to oxaliplatin. Mass spectrometry protein identification, co-immunoprecipitation of AKAP8L with IGF2BP1, RIP assay for AKAP8L-SCD1 mRNA interaction, AKAP8L overexpression/knockdown with SCD1 rescue Cell death & disease Medium 36522343
2023 SCD1 positively regulates squalene epoxidase (SQLE) transcription by eliminating transcriptional inhibition by P53, thereby increasing cholesterol content. Elevated cholesterol regulated by SCD1 inhibits ferroptosis via the mTOR signaling pathway, promoting gastric cancer stem cell (GCSC) stemness. SCD1 knockdown, SQLE expression and promoter analysis, P53 binding assays, cholesterol measurement, mTOR pathway analysis, in vivo tumor stemness assays International journal of biological macromolecules Medium 38972654
2023 METTL14-mediated m6A modification of SCD1 mRNA increases its recognition by the m6A reader YTHDF2, which destabilizes SCD1 mRNA and diminishes SCD1 expression, thereby suppressing Wnt/β-catenin signaling and colon cancer stemness and metastasis. METTL14 overexpression/knockdown, m6A methylation analysis of SCD1 mRNA, YTHDF2 RIP assay, mRNA stability assay, Wnt/β-catenin reporter assay Molecular biotechnology Medium 37592151
2021 HNF4A directly binds to key regulatory regions in the SCD1 locus. Knockdown of HNF4A significantly downregulates SCD1 expression. Two SNPs (rs55710213 and rs56334587) in intron 5 of SCD1 reside in a canonical HNF4A binding site; the GG haplotype disrupts HNF4A binding, reducing enhancer activity and SCD1 expression. HNF4A ChIP, HNF4A knockdown, luciferase reporter assay with SCD1 regulatory regions, allele-specific HNF4A binding analysis Biochimica et biophysica acta. Gene regulatory mechanisms Medium 34171462
2021 High-fructose diet increases ChREBP binding to the Scd1 gene promoter and enhances histone H3 and H4 acetylation at this promoter, upregulating Scd1 expression in rat liver. Chromatin immunoprecipitation (ChIP) for ChREBP and histone acetylation at the Scd1 promoter, high-fructose diet rat model, gene expression and triglyceride measurement Biomedical research (Tokyo, Japan) Medium 33840688
2013 Genetic ablation of SCD1 alone does not inhibit AKT-driven hepatic steatosis or AKT/Ras-induced hepatocarcinogenesis in mice. SCD2 is strongly upregulated to compensate in SCD1-null liver tumors. Simultaneous silencing of both SCD1 and SCD2 is required to inhibit growth of AKT/Ras cells in vitro. SCD1 knockout mice, hydrodynamic injection of AKT/Ras oncogenes, liver tumor analysis, SCD2 expression analysis, siRNA co-silencing of SCD1 and SCD2 PloS one High 24069385
2024 Exercise increases endothelial SCD1 expression, which catalyzes production of oleic acid (OA) and palmitoleic acid (PA), mitigating NF-κB-mediated inflammatory responses. Endothelial-specific Scd1 deletion (Ldlr-/- Scd1EC-/- mice) on high-fat diet results in persistent VCAM1-positive endothelium; SCD1 overexpression via adenovirus mitigates ER stress and inflammatory biomarkers. Voluntary wheel running exercise, untargeted metabolomics, endothelial-specific Scd1 deletion in mice, adenoviral SCD1 overexpression, single-cell transcriptomics of aorta, inflammatory marker assays Science advances High 38354249
2024 SCD1 inhibition downregulates SLC7A11 expression via the AKT-GSK3β-NRF2 signaling axis, promoting ferroptosis and altering fatty acid metabolism. This mechanism was validated by transcriptomics, lipidomics, and kinase array analysis in preclinical KRASmut LUAD models. SCD1 inhibition, transcriptomics, lipidomics, kinase array, AKT-GSK3β-NRF2 pathway analysis, xenograft tumor models Cancer research Medium 40198901
2024 SCD1 knockdown in cardiac fibroblasts activates PGC1α and PPARβ signaling, enhancing fatty acid oxidation (FAO)-related gene expression and mitochondrial biogenesis, thereby improving cardiac reprogramming efficiency (conversion of fibroblasts to induced cardiomyocytes). Scd1 knockdown, single-cell metabolic flux estimation, flux balance analysis, PGC1α/PPARβ pathway analysis, pharmacological SCD1 inhibition, mitochondrial biogenesis assays Molecular therapy Medium 40007118
2024 METTL16-mediated m6A modification of SCD1 mRNA increases its degradation via the m6A reader YTHDC2. METTL16 downregulation (due to DNMT1-mediated promoter hypermethylation) reduces m6A on SCD1 mRNA, increasing SCD1 expression and lipid metabolism, promoting papillary thyroid cancer progression. METTL16 gain/loss-of-function, m6A abundance measurement on SCD1 mRNA, YTHDC2 reader assay, RNA decay assay, SCD1 inhibitor A939572 Cellular and molecular life sciences Medium 38334797
2024 IGF2BP3 regulates SCD mRNA m6A modifications via an IGF2BP3-METTL14 complex, enhancing SCD mRNA stability and thereby promoting lipid metabolism, proliferation, and metastasis in cervical cancer. RIP assay confirmed IGF2BP3 binding to SCD mRNA. RNA-seq target identification, RIP assay for IGF2BP3-SCD mRNA binding, methylated RNA immunoprecipitation (MeRIP), IGF2BP3 knockdown with SCD overexpression rescue, in vivo tumor model Cell death & disease Medium 38355626
2024 LDHA-mediated histone H3K18 lactylation is enriched on the METTL3 promoter, upregulating METTL3 expression. METTL3 increases m6A modification of SCD1 mRNA, recognized by YTHDF1 which stabilizes SCD1 mRNA, promoting lipid accumulation and NAFLD progression. IP and dual-luciferase reporter for H3K18lac on METTL3 promoter, METTL3/LDHA knockdown, m6A measurement of SCD1 mRNA, YTHDF1 RIP, RNA decay assay Physiological research Medium 39903889
2022 SCD1 inhibition in colorectal cancer cells decreases MUFA levels, activates NF-κB pathway and de novo ceramide synthesis. A separate study (Liu et al.) shows TIGAR inhibition represses SCD1 expression in a ROS/AMPK-dependent manner, rendering colorectal cancer cells more sensitive to ferroptosis. SCD1 inhibitor, TIGAR knockdown, AMPK activation assay, ROS measurement, ferroptosis markers (MDA, GSH/GSSG, lipid peroxidation) Free radical biology & medicine Medium 35271998
2023 Nodal overexpression transcriptionally upregulates SCD1 via Smad2/3 pathway activation, inducing monounsaturated fatty acid synthesis and protecting colorectal cancer cells from ferroptosis. SCD1 inhibition at least partially abolishes the resistance of Nodal-overexpressing cells to RSL3-induced ferroptosis. Nodal overexpression/knockdown, Smad2/3 pathway analysis, SCD1 luciferase reporter, lipid peroxidation assays, ferroptosis induction, in vivo tumor models Cell death & disease Medium 37002201
2024 SCD1 inhibition (via the RIFSP-2 peptide) limits MUFA biogenesis and decreases radiation-induced STING-mediated inflammation and pyroptosis. RIFSP-2 was identified as a direct binding target of SCD1 via a streptavidin-biotin pull-down system; lipidomic analysis confirmed that RIFSP-2 treatment restrains MUFA biogenesis. Streptavidin-biotin pull-down to identify SCD1 as RIFSP-2 target, lipidomics, STING pathway analysis, in vivo irradiation model Advanced science Medium 38582510
2024 SULT2B1 directly interacts with SCD1 to facilitate lipid metabolism and promote colon cancer metastasis. Combined application of SCD1 inhibitor and SULT2B1 knockout showed a more robust inhibitory effect on lipid metabolism and metastasis than SULT2B1 knockout alone. Co-immunoprecipitation of SULT2B1 with SCD1, SULT2B1 knockout, SCD1 inhibitor CAY, lipid metabolism assays, orthotopic tumor model Clinical and translational medicine Medium 38372484
2024 Specific SCD1 inhibition in primary proximal tubular epithelial cells activates cGAS/STING signaling, and HDD treatment of renal fibrosis restores SCD1 expression while suppressing this pathway. This places SCD1 upstream of cGAS/STING signaling in renal tubular cells. SCD1 inhibitor A939572 in primary PTECs, cGAS/STING signaling markers, renal fibrosis mouse model, lipidomics Journal of ethnopharmacology Medium 39832629
2024 Scd1 deficiency in adipocytes impairs autophagosome-lysosome fusion and lysosomal/autolysosomal acidification, leading to vacuole accumulation and cell death. Supplementation with monounsaturated fatty acids restores viability of Scd1-deficient adipocytes. In vivo, Scd1 deletion leads to loss of bone marrow adipocytes through autophagy-dependent cell death. Scd1 knockout adipocytes and mouse models, pharmacological SCD1 inhibition, autophagy flux assays, MUFA supplementation rescue, autophagosome formation inhibitor Molecular metabolism High 38492843
2023 SCD1 in sebocytes catalyzes the Δ9 desaturation of palmitate (C16:0) to palmitoleate (C16:1n-7), while FADS2 catalyzes Δ6 desaturation to sapienate (C16:1n-10). Specific inhibition of SCD1 in SZ95 sebocytes enhances lipoinflammation induced by saturated fatty acids, indicating that SCD1-mediated desaturation normally limits inflammatory responses in sebaceous cells. Specific SCD1 and FADS2 inhibitors in SZ95 sebocytes, fatty acid profiling, IL-6/IL-8 cytokine measurement, lipid quantification Experimental dermatology Medium 36843338

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2020 HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications. Cell reports 352 33296645
1995 The regulation of stearoyl-CoA desaturase (SCD). Progress in lipid research 285 7480063
2021 Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence. Redox biology 231 34030117
2019 Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway. Free radical biology & medicine 220 31226399
2020 FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells. Redox biology 218 33271455
2020 Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer. Cell reports 200 33264619
2021 SCD1, autophagy and cancer: implications for therapy. Journal of experimental & clinical cancer research : CR 121 34429143
2019 Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity. Molecular cell 106 31733993
2017 MicroRNA-27a regulates hepatic lipid metabolism and alleviates NAFLD via repressing FAS and SCD1. Scientific reports 99 29101357
2022 TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/SCD1 pathway. Free radical biology & medicine 93 35271998
2023 ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer. Nature communications 89 37208334
2023 SCD1 is the critical signaling hub to mediate metabolic diseases: Mechanism and the development of its inhibitors. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 89 38042113
2022 Long noncoding RNA LINC01606 protects colon cancer cells from ferroptotic cell death and promotes stemness by SCD1-Wnt/β-catenin-TFE3 feedback loop signalling. Clinical and translational medicine 89 35485210
2022 An SCD1-dependent mechanoresponsive pathway promotes HCC invasion and metastasis through lipid metabolic reprogramming. Molecular therapy : the journal of the American Society of Gene Therapy 84 35358687
2022 Inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor T cell response through regulating β-catenin signaling in cancer cells and ER stress in T cells and synergizes with anti-PD-1 antibody. Journal for immunotherapy of cancer 83 35793868
2022 Sorafenib triggers ferroptosis via inhibition of HBXIP/SCD axis in hepatocellular carcinoma. Acta pharmacologica Sinica 73 36109580
2022 Agrimonolide inhibits cancer progression and induces ferroptosis and apoptosis by targeting SCD1 in ovarian cancer cells. Phytomedicine : international journal of phytotherapy and phytopharmacology 63 35526323
2024 Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy. Journal of advanced research 60 39353532
2017 SCD1 and SCD2 Form a Complex That Functions with the Exocyst and RabE1 in Exocytosis and Cytokinesis. The Plant cell 58 28970336
2017 Oleate activates SREBP-1 signaling activity in SCD1-deficient hepatocytes. American journal of physiology. Endocrinology and metabolism 56 28851735
2022 PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling. Nature communications 48 35624087
2019 SCD1 regulates the AMPK/SIRT1 pathway and histone acetylation through changes in adenine nucleotide metabolism in skeletal muscle. Journal of cellular physiology 45 31241768
2021 Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling. Molecular metabolism 44 33676027
2020 Sulforaphene inhibits esophageal cancer progression via suppressing SCD and CDH3 expression, and activating the GADD45B-MAP2K3-p38-p53 feedback loop. Cell death & disease 39 32873775
2020 MicroRNA-103 represses hepatic de novo lipogenesis and alleviates NAFLD via targeting FASN and SCD1. Biochemical and biophysical research communications 38 32035613
2018 Newborn Screening for SCD in the USA and Canada. International journal of neonatal screening 38 33072956
2019 Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway. Journal of experimental & clinical cancer research : CR 37 30791926
2024 METTL16 inhibits papillary thyroid cancer tumorigenicity through m6A/YTHDC2/SCD1-regulated lipid metabolism. Cellular and molecular life sciences : CMLS 36 38334797
1993 Psychosocial aspects of sickle cell disease (SCD) in childhood and adolescence: a review. The British journal of clinical psychology 36 8251957
2019 Sudden Cardiac Death (SCD) - risk stratification and prediction with molecular biomarkers. Journal of biomedical science 34 31118017
2022 Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model. Blood cells, molecules & diseases 33 35366607
2021 Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy. The Journal of clinical investigation 33 33690217
2020 N-glycosylation of CREBH improves lipid metabolism and attenuates lipotoxicity in NAFLD by modulating PPARα and SCD-1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 33 32996649
2024 IGF2BP3 enhances lipid metabolism in cervical cancer by upregulating the expression of SCD. Cell death & disease 31 38355626
2023 Predictors of cognitive deterioration in subjective cognitive decline: evidence from longitudinal studies and implications for SCD-plus criteria. Journal of neurology, neurosurgery, and psychiatry 31 36868847
2023 CircZBTB46 Protects Acute Myeloid Leukemia Cells from Ferroptotic Cell Death by Upregulating SCD. Cancers 29 36672408
2023 Inhibiting SCD expression by IGF1R during lorlatinib therapy sensitizes melanoma to ferroptosis. Redox biology 29 36889082
2023 Nodal promotes colorectal cancer survival and metastasis through regulating SCD1-mediated ferroptosis resistance. Cell death & disease 29 37002201
2023 SCD1 inhibition enhances the effector functions of CD8+ T cells via ACAT1-dependent reduction of esterified cholesterol. Cancer science 29 37879607
2025 SCD1 Inhibition Blocks the AKT-NRF2-SLC7A11 Pathway to Induce Lipid Metabolism Remodeling and Ferroptosis Priming in Lung Adenocarcinoma. Cancer research 23 40198901
2024 Sulfotransferase SULT2B1 facilitates colon cancer metastasis by promoting SCD1-mediated lipid metabolism. Clinical and translational medicine 21 38372484
2022 SCD1 is nutritionally and spatially regulated in the intestine and influences systemic postprandial lipid homeostasis and gut-liver crosstalk. Biochimica et biophysica acta. Molecular and cell biology of lipids 21 35718096
2023 A high-throughput newborn screening approach for SCID, SMA, and SCD combining multiplex qPCR and tandem mass spectrometry. PloS one 20 36897914
2022 Selenocysteine Machinery Primarily Supports TXNRD1 and GPX4 Functions and Together They Are Functionally Linked with SCD and PRDX6. Biomolecules 20 36008942
2019 The Neonatal Screening Program in Brazil, Focus on Sickle Cell Disease (SCD). International journal of neonatal screening 20 33072971
2014 Association of BTG2, CYR61, ZFP36, and SCD gene polymorphisms with Graves' disease and ophthalmopathy. Thyroid : official journal of the American Thyroid Association 20 24780075
2013 SCD1 Expression is dispensable for hepatocarcinogenesis induced by AKT and Ras oncogenes in mice. PloS one 20 24069385
2024 SCD1 promotes the stemness of gastric cancer stem cells by inhibiting ferroptosis through the SQLE/cholesterol/mTOR signalling pathway. International journal of biological macromolecules 19 38972654
2023 TGF-β1 promotes SCD1 expression via the PI3K-Akt-mTOR-SREBP1 signaling pathway in lung fibroblasts. Respiratory research 19 36627645
2022 AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA. Cell death & disease 19 36522343
2021 The Effects of Treatment with Blood Transfusion, Iron Chelation and Hydroxyurea on Puberty, Growth and Spermatogenesis in Sickle Cell Disease (SCD): A short update. Acta bio-medica : Atenei Parmensis 19 34487059
2022 Tumor Microenvironment Acidity Triggers Lipid Accumulation in Liver Cancer via SCD1 Activation. Molecular cancer research : MCR 18 35046108
2020 Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme. Biomolecules 18 32392704
2024 Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolites. Science advances 16 38354249
2024 A Frog Skin-Derived Peptide Targeting SCD1 Exerts Radioprotective Effects Against Skin Injury by Inhibiting STING-Mediated Inflammation. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 16 38582510
2024 Formononetin triggers ferroptosis in triple-negative breast cancer cells by regulating the mTORC1/SREBP1/SCD1 pathway. Frontiers in pharmacology 15 39399463
2023 Circular RNA RHBDD1 regulates tumorigenicity and ferroptosis in colorectal cancer by mediating the ELAVL1/SCD mRNA interaction. Cancer gene therapy 15 38072968
2022 MEN1 promotes ferroptosis by inhibiting mTOR-SCD1 axis in pancreatic neuroendocrine tumors. Acta biochimica et biophysica Sinica 15 36604142
2024 Reprimo (RPRM) mediates neuronal ferroptosis via CREB-Nrf2/SCD1 pathways in radiation-induced brain injury. Free radical biology & medicine 14 38272326
2021 Stearoyl-CoA Desaturase (SCD) Induces Cardiac Dysfunction with Cardiac Lipid Overload and Angiotensin II AT1 Receptor Protein Up-Regulation. International journal of molecular sciences 14 34576047
2024 Scd1 and monounsaturated lipids are required for autophagy and survival of adipocytes. Molecular metabolism 13 38492843
2022 Outcome of Hydroxyurea Use in SCD and Evaluation of Patients' Perception and Experience in Nigeria. Frontiers in genetics 13 35401653
2022 Mechanism of SCD Participation in Lipid Droplet-Mediated Steroidogenesis in Goose Granulosa Cells. Genes 13 36140684
2020 Metabolomic Analysis of SCD during Goose Follicular Development: Implications for Lipid Metabolism. Genes 13 32858946
2025 Huangqi-Danshen decoction alleviates renal fibrosis through targeting SCD1 to modulate cGAS/STING signaling. Journal of ethnopharmacology 12 39832629
2024 Active AKT2 stimulation of SREBP1/SCD1-mediated lipid metabolism boosts hepatosteatosis and cancer. Translational research : the journal of laboratory and clinical medicine 12 38244769
2024 Sickle cell disease in Indian tribal population: Findings of a multi-centre Indian SCD registry. Blood cells, molecules & diseases 12 39024737
2024 Artesunate-binding FABP5 promotes apoptosis in lung cancer cells via the PPARγ-SCD pathway. International immunopharmacology 12 39405934
2022 The Sickle Cell Disease Functional Assessment (SCD-FA) tool: a feasibility pilot study. Pilot and feasibility studies 12 35246265
2022 Topical SCD-153, a 4-methyl itaconate prodrug, for the treatment of alopecia areata. PNAS nexus 12 36712931
2021 NF-κB pathway play a role in SCD1 deficiency-induced ceramide de novo synthesis. Cancer biology & therapy 12 33612070
2025 Piezo1 regulates colon stem cells to maintain epithelial homeostasis through SCD1-Wnt-β-catenin and programming fatty acid metabolism. Cell reports 11 40080500
2023 A Scd1-mediated metabolic alteration participates in liver responses to low-dose bavachin. Journal of pharmaceutical analysis 11 37577386
2022 Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis : Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis. Journal of physiology and biochemistry 11 35122619
2022 Antidiabetic Effect of Rehmanniae Radix Based on Regulation of TRPV1 and SCD1. Frontiers in pharmacology 11 35694255
2025 C12ORF49 inhibits ferroptosis in hepatocellular carcinoma cells via reprogramming SREBP1/SCD1-mediated lipid metabolism. Cell death discovery 10 40240331
2025 Circular RNA TFRC/SCD1 mRNA interaction regulates ferroptosis and metastasis in gastric cancer. Cell death & disease 10 40473597
2024 GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid metabolism via p38-SCD1 axis. Apoptosis : an international journal on programmed cell death 10 39306652
2024 Leonurine Inhibits Hepatic Lipid Synthesis to Ameliorate NAFLD via the ADRA1a/AMPK/SCD1 Axis. International journal of molecular sciences 10 39409181
2023 Uncarboxylated Osteocalcin Decreases SCD1 by Activating AMPK to Alleviate Hepatocyte Lipid Accumulation. Molecules (Basel, Switzerland) 10 37049884
2023 METTL14 Suppresses Tumor Stemness and Metastasis of Colon Cancer Cells by Modulating m6A-Modified SCD1. Molecular biotechnology 10 37592151
2023 Clinical and epidemiological features and therapeutic options of avascular necrosis in patients with sickle cell disease (SCD): a cross-sectional study. Acta bio-medica : Atenei Parmensis 10 37850770
2015 An SCD gene from the Mollusca and its upregulation in carotenoid-enriched scallops. Gene 10 25816753
2024 CRISPR/Cas9 in the treatment of sickle cell disease (SCD) and its comparison with traditional treatment approaches: a review. Annals of medicine and surgery (2012) 9 39359808
2023 HOXB9 a miR-122-5p regulated gene, suppressed the anticancer effects of brusatol by upregulating SCD1 expression in melanoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 9 37031492
2023 MicroRNA-199a-3p suppresses the invasion and metastasis of nasopharyngeal carcinoma through SCD1/PTEN/AKT signaling pathway. Cellular signalling 9 37543098
2023 Reduced liver damage and fibrosis with combined SCD Probiotics and intermittent fasting in aged rat. Journal of cellular and molecular medicine 9 37897241
2022 Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway. BioMed research international 9 35528164
2022 Blood transfusion and iron overload in patients with Sickle Cell Disease (SCD): Personal experience and a short update of diabetes mellitus occurrence. Acta bio-medica : Atenei Parmensis 9 36043959
2022 Upregulation of SCD1 by ErbB2 via LDHA promotes breast cancer cell migration and invasion. Medical oncology (Northwood, London, England) 9 36471172
2022 SCD1 Sustains Homeostasis of Bulge Niche via Maintaining Hemidesmosomes in Basal Keratinocytes. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 9 36507562
2021 Modulation of SCD1 activity in hepatocyte cell lines: evaluation of genomic stability and proliferation. Molecular and cellular biochemistry 9 33954906
2021 Polymorphisms rs55710213 and rs56334587 regulate SCD1 expression by modulating HNF4A binding. Biochimica et biophysica acta. Gene regulatory mechanisms 9 34171462
2025 Enhanced fatty acid oxidation via SCD1 downregulation fuels cardiac reprogramming. Molecular therapy : the journal of the American Society of Gene Therapy 8 40007118
2024 PPP2CA Inhibition Promotes Ferroptosis Sensitivity Through AMPK/SCD1 Pathway in Colorectal Cancer. Digestive diseases and sciences 8 38637456
2024 LDHA- Mediated Histone Lactylation Promotes the Nonalcoholic Fatty Liver Disease Progression Through Targeting The METTL3/ YTHDF1/SCD1 m6A Axis. Physiological research 8 39903889
2023 Desaturation of sebaceous-type saturated fatty acids through the SCD1 and the FADS2 pathways impacts lipid neosynthesis and inflammatory response in sebocytes in culture. Experimental dermatology 8 36843338
2022 Transition in Sickle Cell Disease (SCD): A German Consensus Recommendation. Journal of personalized medicine 8 35887653
2021 High-fructose diet-induced hepatic expression of the Scd1 gene is associated with increased acetylation of histones H3 and H4 and the binding of ChREBP at the Scd1 promoter in rats. Biomedical research (Tokyo, Japan) 8 33840688
2024 Exosomes derived from periodontitis induce hepatic steatosis through the SCD-1/AMPK signaling pathway. Biochimica et biophysica acta. Molecular basis of disease 7 38986822

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