Affinage

RPS15A

Small ribosomal subunit protein uS8 · UniProt P62244

Length
130 aa
Mass
14.8 kDa
Annotated
2026-04-28
45 papers in source corpus 20 papers cited in narrative 20 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPS15A is a core structural component of the 40S ribosomal subunit that is essential for ribosome biogenesis, rRNA processing, and translational integrity, and functions as an oncogenic signaling hub in multiple cancer types (PMID:8185605, PMID:40239541). Loss of RPS15A disrupts nucleolar architecture, impairs pre-rRNA and mature rRNA synthesis, and triggers nucleolar stress-mediated p53/p21 activation leading to cell cycle arrest and apoptosis (PMID:40239541, PMID:26989627). Beyond its ribosomal role, RPS15A activates Wnt/β-catenin, Akt/IKK-β/NF-κB, mTOR, and ERK1/2 signaling to promote proliferation, survival, and angiogenesis; its protein stability is regulated by FBXL18-mediated K63-linked ubiquitination, GGCT binding, and lncRNA RHPN1-AS1, while its expression is transcriptionally repressed by FOXN3 and post-transcriptionally suppressed by miR-29, miR-519d-3p, and miR-147b (PMID:29242604, PMID:30661291, PMID:37378633, PMID:40044122, PMID:41026296, PMID:37016167, PMID:31665807). RPS15A overexpression drives hepatocellular carcinoma development downstream of hepatitis B virus X antigen and promotes tumor formation in xenograft models (PMID:15108328, PMID:29242604).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 1994 High

    Establishing the identity of RPS15A as a 40S ribosomal subunit protein resolved its primary structure and gene organization, providing the foundation for all subsequent functional studies.

    Evidence cDNA cloning, sequencing, and Southern/Northern blotting in rat

    PMID:8185605

    Open questions at the time
    • No functional data on ribosomal role beyond structural membership
    • Post-translational modifications uncharacterized
    • Human ortholog not yet cloned at this point
  2. 2004 Medium

    The discovery that HBxAg upregulates RPS15A and that its overexpression transforms cells and drives tumor formation in SCID mice established the first link between a ribosomal protein and oncogenic extra-ribosomal function.

    Evidence PCR-select cDNA subtraction, soft-agar colony formation, and SCID mouse xenograft in HCC context

    PMID:15108328

    Open questions at the time
    • Mechanism of HBxAg-mediated upregulation undefined
    • Downstream signaling pathways not identified
    • Whether oncogenic activity is translation-dependent or extra-ribosomal remained unclear
  3. 2013 Medium

    Demonstrating that RPS15A knockdown arrests hepatic cancer cells at G0/G1 established that RPS15A is required for cell cycle progression, not merely permissive for growth.

    Evidence Lentiviral shRNA knockdown with MTT, colony formation, and flow cytometry in HepG2 and Bel7404 cells

    PMID:24334120

    Open questions at the time
    • Cell cycle targets (cyclins, CDKs) not identified
    • No pathway mechanism defined
    • Off-target effects of single shRNA not fully excluded
  4. 2015 Medium

    Identification of decreased p-Akt upon RPS15A knockdown in glioblastoma placed RPS15A upstream of AKT signaling and linked it to migration and in vivo tumor growth beyond HCC.

    Evidence Lentiviral RNAi with p-Akt Western blot and nude mouse xenograft in U87/U251 glioblastoma cells

    PMID:26537582

    Open questions at the time
    • Direct versus indirect activation of AKT not resolved
    • Mechanism linking a ribosomal protein to AKT unknown
    • Whether translation-dependent or independent unclear
  5. 2016 Medium

    Demonstration that RPS15A knockdown activates caspase-3, cleaves PARP, and reduces Bcl-2 defined a pro-survival/anti-apoptotic mechanism, while microarray analysis in lung cancer linked RPS15A loss to p53 pathway activation.

    Evidence Lentiviral RNAi with apoptosis marker Western blots in glioblastoma; gene expression microarray in lung adenocarcinoma

    PMID:26989627 PMID:27130037

    Open questions at the time
    • Whether p53 activation is a direct consequence of nucleolar stress was not tested
    • No epistasis experiments with p53 at this stage
    • Single cell line per study
  6. 2017 High

    Elucidation of the RPS15A→Wnt/β-catenin→FGF18→FGFR3 paracrine angiogenesis axis in HCC revealed a specific extra-ribosomal oncogenic signaling mechanism and the first non-cell-autonomous function, while miR-29 family members were validated as direct post-transcriptional suppressors of RPS15A.

    Evidence HUVEC co-culture paracrine assay, reporter assays, and xenograft for angiogenesis; luciferase 3′-UTR reporter for miR-29 targeting

    PMID:29242604 PMID:31966655

    Open questions at the time
    • Whether RPS15A directly binds β-catenin or acts through translation is unknown
    • Physiological relevance of miR-29-RPS15A axis in non-cancer tissue not tested
  7. 2019 High

    Pharmacological epistasis using AKT and IKK inhibitors defined RPS15A as an upstream activator of the Akt/IKK-β/NF-κB cascade in gastric cancer; concurrent studies validated miR-519d-3p and miR-147b as additional direct miRNA regulators suppressing RPS15A/Wnt signaling, and identified the ERK1/2/Bad/Chk1 anti-apoptotic axis in breast cancer.

    Evidence NF-κB reporter with LY294002/Bay117082 in gastric cancer; luciferase reporters and rescue in pancreatic/NSCLC cells; p-ERK/p-Bad/p-Chk1 Western blots in MDA-MB-231

    PMID:30661291 PMID:30831090 PMID:31535410 PMID:31665807

    Open questions at the time
    • No direct physical interaction between RPS15A and AKT or IKK-β demonstrated
    • How a ribosomal protein specifically activates multiple kinase cascades remains mechanistically opaque
    • Relative contribution of translational versus extra-ribosomal functions unclear
  8. 2022 Medium

    Placing RPS15A downstream of PSMC2/let-7c-3p and upstream of mTOR, with Torin1 partially reversing RPS15A-driven proliferation, extended the signaling network to the mTOR pathway.

    Evidence GeneChip analysis, dual-luciferase reporter, RPS15A overexpression rescue, Torin1 pharmacological inhibition

    PMID:35256584

    Open questions at the time
    • Direct RPS15A–mTOR interaction not shown
    • Partial rescue by Torin1 implies additional pathways
    • Single cancer type tested
  9. 2023 High

    Discovery that FBXL18 catalyzes K63-linked ubiquitination to stabilize RPS15A protein, which in turn elevates SMAD3 and promotes its nuclear translocation, established the first defined post-translational regulatory mechanism and a new downstream effector; FOXN3 was identified as a direct transcriptional repressor binding the RPS15A promoter.

    Evidence K63-linkage-specific ubiquitination assay, Co-IP, FBXL18 transgenic mice, epistatic knockdown rescue for SMAD3 axis; ChIP and luciferase promoter assay for FOXN3

    PMID:37016167 PMID:37378633

    Open questions at the time
    • Whether K63-Ub affects RPS15A ribosomal incorporation or only extra-ribosomal pools is unknown
    • SMAD3 activation mechanism (direct binding vs. translational) not resolved
    • FOXN3 regulation in non-ovarian contexts untested
  10. 2025 High

    Demonstration that RPS15A knockdown impairs rRNA biogenesis, disrupts nucleolar architecture (NPM1/FBL displacement), and triggers p53/p21-dependent arrest—with p53 knockdown rescuing rRNA processing—definitively linked RPS15A to nucleolar stress surveillance; GGCT was identified as a stabilizing physical interactor, and lncRNA RHPN1-AS1 as an additional stabilizer activating β-catenin.

    Evidence rRNA processing RT-PCR, NPM1/FBL immunofluorescence, p53 epistasis rescue in B-ALL; Co-IP/LC-MS/MS for GGCT; RNA pull-down for RHPN1-AS1 in hypoxic HCC

    PMID:40044122 PMID:40239541 PMID:41026296

    Open questions at the time
    • Structural basis for RPS15A's role in rRNA processing unknown
    • Whether GGCT stabilization uses ubiquitin-dependent or -independent mechanism not defined
    • Ferroptosis link via p53/SLC7A11 axis awaits validation in additional cancer types

Open questions

Synthesis pass · forward-looking unresolved questions
  • The fundamental question of how a ribosomal protein activates multiple distinct kinase cascades (AKT, ERK, mTOR, NF-κB, Wnt/β-catenin) — whether through selective translational control of specific mRNAs, direct extra-ribosomal protein interactions, or specialized ribosome populations — remains unresolved.
  • No ribosome profiling or selective translation data exist for RPS15A perturbation
  • Extra-ribosomal pool versus ribosome-incorporated pool not distinguished in any study
  • No structural model of RPS15A within the human 40S subunit has been functionally interrogated

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 2
Localization
GO:0005829 cytosol 2 GO:0005840 ribosome 2 GO:0005730 nucleolus 1
Pathway
R-HSA-162582 Signal Transduction 6 R-HSA-5357801 Programmed Cell Death 4 R-HSA-1640170 Cell Cycle 3 R-HSA-1643685 Disease 3 R-HSA-392499 Metabolism of proteins 2
Partners
FBLFBXL18GGCTNPM1RHPN1-AS1SMAD3
Complex memberships
40S ribosomal subunit

Evidence

Reading pass · 20 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1994 Rat RPS15A (S15a) is a component of the 40S ribosomal subunit, consists of 129 amino acids (NH2-terminal methionine removed post-translationally), and is encoded by a multi-copy gene family (10–15 copies) producing an ~650 nt mRNA. cDNA cloning, nucleotide sequencing, Southern/Northern blotting Biochemical and biophysical research communications High 8185605
2004 Human RPS15A (S15a) expression is upregulated by hepatitis B virus X antigen (HBxAg); overexpression of S15a stimulates cell growth, colony formation in soft agar, and tumor formation in SCID mice, implicating it in translational integrity and HCC development. PCR-select cDNA subtraction, Northern/Western blotting, soft-agar colony formation, SCID mouse xenograft Molecular carcinogenesis Medium 15108328
2013 shRNA-mediated knockdown of RPS15A inhibits hepatic cancer cell (HepG2, Bel7404) proliferation, impairs colony formation, and arrests cells at G0/G1 phase, demonstrating a required role in cell cycle progression. Lentiviral shRNA knockdown, MTT/colony formation assays, flow cytometry cell-cycle analysis Gene Medium 24334120
2015 RPS15A knockdown in glioblastoma cells (U87, U251) decreases p-Akt levels, arrests cells at G0/G1, inhibits proliferation and migration in vitro, and suppresses tumor growth in nude mice, placing RPS15A upstream of the AKT pathway. Lentiviral RNAi, Western blot (p-Akt), MTT, wound-healing, transwell migration, nude mouse xenograft Tumour biology Medium 26537582
2016 RPS15A knockdown in glioblastoma U251 cells inhibits growth, induces G0/G1 arrest, triggers apoptosis, decreases Bcl-2 protein, and activates caspase-3 and PARP cleavage, defining a pro-survival/anti-apoptotic mechanism. Lentiviral RNAi, MTT, colony formation, flow cytometry, Western blot (Bcl-2, caspase-3, PARP) World journal of surgical oncology Medium 27130037
2016 In lung adenocarcinoma cells, RPS15A knockdown inhibits growth, induces apoptosis, and activates the p53 signaling pathway as revealed by gene expression microarray, suggesting RPS15A suppresses p53 activity. Lentiviral shRNA, gene expression microarray, flow cytometry PeerJ Medium 26989627
2017 RPS15A promotes tumor angiogenesis in hepatocellular carcinoma by enhancing Wnt/β-catenin-mediated FGF18 expression in HCC cells; secreted FGF18 then binds FGFR3 on endothelial cells to activate AKT and ERK, stimulating angiogenesis. HCC cell overexpression/knockdown, HUVEC co-culture paracrine angiogenesis assay, reporter assays, Western blot, nude mouse xenograft Oncogene High 29242604
2017 miR-29 family members directly bind the 3′-UTR of RPS15A mRNA (validated by luciferase assay) and reduce RPS15A protein, consequently downregulating cyclin A, cyclin D1 and upregulating p21, thereby regulating cell cycle in HCC. Luciferase 3′-UTR reporter assay, Western blot, cell cycle analysis International journal of clinical and experimental pathology Medium 31966655
2019 RPS15A activates the NF-κB pathway in gastric cancer by inducing Akt/IKK-β signaling, leading to phosphorylation and nuclear translocation of p65; both Akt inhibitor LY294002 and IKK inhibitor Bay117082 block p65 nuclear translocation induced by RPS15A overexpression, placing RPS15A upstream of Akt/IKK-β/NF-κB. Overexpression/knockdown, NF-κB reporter assay, Western blot (p-p65, nuclear fractionation), pharmacological inhibitors, in vivo xenograft Journal of cellular and molecular medicine High 30661291
2019 RPS15A is a direct target of miR-519d-3p (validated by luciferase reporter); RPS15A knockdown downregulates β-catenin and blocks Wnt/β-catenin signaling in pancreatic cancer cells; restoration of RPS15A reverses the antitumor effect of miR-519d-3p. Luciferase 3′-UTR reporter assay, Western blot, cell proliferation assay, rescue experiment Chemico-biological interactions Medium 30831090
2019 RPS15A knockdown in breast cancer MDA-MB-231 cells suppresses phosphorylation of ERK1/2, Bad, and Chk1, and activates caspase-3/-7, indicating RPS15A inhibits apoptosis via the ERK1/2/Bad/Chk1 axis. Lentiviral shRNA, Western blot (p-ERK1/2, p-Bad, p-Chk1), caspase-3/-7 activity assay Journal of cellular biochemistry Medium 31535410
2019 miR-147b directly targets RPS15A (validated by luciferase reporter), negatively regulates its expression in NSCLC cells, and thereby downregulates Wnt/β-catenin signaling; overexpression of RPS15A partially reverses the antitumor effect of miR-147b. Luciferase 3′-UTR reporter assay, Western blot, functional rescue experiment Clinical and experimental pharmacology & physiology Medium 31665807
2021 RPS15A knockdown in colorectal cancer RKO cells induces apoptosis via regulation of BIRC3, p38 MAPK, and Chk1, and causes G2/M arrest, as identified by KEGG pathway analysis of 785 differentially expressed genes and confirmed by Western blot. Lentiviral shRNA, microarray/KEGG pathway analysis, Western blot, flow cytometry, nude mouse xenograft European review for medical and pharmacological sciences Medium 34156695
2022 PSMC2 promotes RPS15A expression by competitively binding hsa-let-7c-3p; elevated RPS15A in turn activates the mTOR pathway; mTOR inhibitor Torin1 partially reverses RPS15A-overexpression-induced proliferation, placing RPS15A downstream of PSMC2/let-7c-3p and upstream of mTOR. GeneChip analysis, dual-luciferase reporter assay, RPS15A overexpression rescue, Torin1 pharmacological inhibition, Western blot Oncogenesis Medium 35256584
2023 FBXL18, an E3 ubiquitin ligase, promotes K63-linked ubiquitination of RPS15A, enhancing its protein stability; stabilized RPS15A increases SMAD3 levels and promotes its nuclear translocation, driving HCC cell proliferation; knockdown of RPS15A or SMAD3 suppresses FBXL18-mediated proliferation. Co-IP, ubiquitination assay (K63-linkage specific), Western blot (SMAD3, nuclear fractionation), FBXL18 transgenic mice, knockdown rescue experiments Hepatology communications High 37378633
2023 FOXN3 transcription factor binds to the RPS15A promoter at two specific sites (−1588/−1581 and −1476/−1467) and represses its transcriptional expression, as shown by dual-luciferase assay and ChIP; RPS15A overexpression reverses FOXN3-mediated suppression of ovarian cancer malignant behaviors. Dual-luciferase promoter assay, ChIP, overexpression rescue experiments Human cell Medium 37016167
2023 miR-147b directly targets RPS15A (validated by luciferase reporter) in prostate cancer cells; RPS15A is downregulated in neuroendocrine prostate cancer cells and its expression is inversely correlated with NE markers; overexpression of miR-147b reduces cyclin D1 and elevates p27kip1, while RPS15A inhibition contributes to neuroendocrine differentiation. Luciferase reporter assay, Western blot, miRNA mimic/inhibitor experiments, RT-PCR The Prostate Medium 37069746
2025 RPS15A knockdown in B-ALL cells impairs ribosomal biogenesis by suppressing synthesis and processing of pre-rRNA, 18S rRNA, 28S rRNA, and 5.8S rRNA; this disrupts nucleolar architecture (displaces NPM1 and FBL), induces nucleolar stress, and activates p53/p21 signaling, causing cell cycle arrest and apoptosis; p53 knockdown after RPS15A KD rescues rRNA biogenesis, cell cycle progression, and inhibits apoptosis. Lentiviral shRNA, immunofluorescence (NPM1/FBL localization), RT-PCR (rRNA processing), flow cytometry, Western blot (p53/p21), p53 rescue experiment Biochemical and biophysical research communications High 40239541
2025 GGCT physically interacts with RPS15A (shown by co-IP and LC-MS/MS) and promotes RPS15A protein stability; RPS15A knockdown activates p53, which represses SLC7A11, reducing GSH synthesis and promoting ferroptosis in papillary thyroid cancer cells; RPS15A overexpression reverses GGCT-knockdown-induced ferroptosis. Co-immunoprecipitation, LC-MS/MS, Western blot, ferroptosis assays (MDA, ROS), rescue overexpression Cancer science Medium 40044122
2025 lncRNA RHPN1-AS1 physically interacts with RPS15A protein and stabilizes it in hypoxic HCC cells; elevated RPS15A then activates β-catenin signaling to promote proliferation and invasion; silencing RPS15A attenuates RHPN1-AS1-induced aggressiveness and β-catenin activation. RNA-protein pull-down/interaction assay, Western blot (β-catenin), knockdown rescue, xenograft tumor model Medical oncology Medium 41026296

Source papers

Stage 0 corpus · 45 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2017 Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma. Oncogene 61 29242604
2019 HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways. Nature communications 44 31604943
2019 RPS15A promotes gastric cancer progression via activation of the Akt/IKK-β/NF-κB signalling pathway. Journal of cellular and molecular medicine 39 30661291
1992 Cytoplasmic ribosomal protein S15a from Brassica napus: molecular cloning and developmental expression in mitotically active tissues. Plant molecular biology 39 1581568
2002 Human cytomegalovirus US7, US8, US9, and US10 are cytoplasmic glycoproteins, not found at cell surfaces, and US9 does not mediate cell-to-cell spread. Journal of virology 38 11992003
2013 Down-regulation of ribosomal protein S15A mRNA with a short hairpin RNA inhibits human hepatic cancer cell growth in vitro. Gene 37 24334120
2004 Human S15a expression is upregulated by hepatitis B virus X protein. Molecular carcinogenesis 30 15108328
2015 Decreased expression of RPS15A suppresses proliferation of lung cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 29 25833696
2015 Down-regulation of ribosomal protein S15A inhibits proliferation of human glioblastoma cells in vivo and in vitro via AKT pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 28 26537582
2022 PSMC2 promotes the progression of gastric cancer via induction of RPS15A/mTOR pathway. Oncogenesis 26 35256584
2002 The human cytomegalovirus US8 glycoprotein binds to major histocompatibility complex class I products. Journal of virology 26 12050396
2019 Overexpression of microRNA-519d-3p suppressed the growth of pancreatic cancer cells by inhibiting ribosomal protein S15A-mediated Wnt/β-catenin signaling. Chemico-biological interactions 25 30831090
2019 Construction of a US7/US8/UL23/US3-deleted recombinant pseudorabies virus and evaluation of its pathogenicity in dogs. Veterinary microbiology 24 31902487
2016 Knockdown of ribosomal protein S15A induces human glioblastoma cell apoptosis. World journal of surgical oncology 20 27130037
2014 Ribosomal protein S15A augments human osteosarcoma cell proliferation in vitro. Cancer biotherapy & radiopharmaceuticals 19 25409460
2019 Downregulation of RPS15A by miR-29a-3p attenuates cell proliferation in colorectal carcinoma. Bioscience, biotechnology, and biochemistry 17 31303129
2016 The effect of ribosomal protein S15a in lung adenocarcinoma. PeerJ 16 26989627
2021 TMED3/RPS15A Axis promotes the development and progression of osteosarcoma. Cancer cell international 15 34838013
1995 Characterization of the US8.5 protein of herpes simplex virus. Archives of virology 15 8572943
2019 MicroRNA-147b suppresses the proliferation and invasion of non-small-cell lung cancer cells through downregulation of Wnt/β-catenin signalling via targeting of RPS15A. Clinical and experimental pharmacology & physiology 14 31665807
1997 Nucleotide sequence of canine herpesvirus homologues of herpes simplex virus type 1 US2, US3, glycoproteins I and E, US8.5 and US9 genes. DNA sequence : the journal of DNA sequencing and mapping 14 9524817
2018 Knockdown of ribosomal protein S15A inhibits proliferation of breast cancer cells through induction of apoptosis in vitro. Cytotechnology 13 29802490
2023 Elevated FBXL18 promotes RPS15A ubiquitination and SMAD3 activation to drive HCC. Hepatology communications 12 37378633
2016 shRNA-mediated RPS15A silencing inhibits U937 acute myeloid leukemia cell proliferation and enhances apoptosis. Molecular medicine reports 12 27035327
1994 The primary structure of rat ribosomal protein S15a. Biochemical and biophysical research communications 11 8185605
2019 Ribosomal protein small subunit 15A (RPS15A) inhibits the apoptosis of breast cancer MDA-MB-231 cells via upregulating phosphorylated ERK1/2, Bad, and Chk1. Journal of cellular biochemistry 9 31535410
2004 Cloning, expression and partial characterization of a gene encoding the S15a ribosomal protein of Taenia solium. Parasitology research 9 14760523
2017 MicroRNA-29 family functions as a tumor suppressor by targeting RPS15A and regulating cell cycle in hepatocellular carcinoma. International journal of clinical and experimental pathology 8 31966655
2018 RPS15a Silencing Suppresses Cell Proliferation and Migration of Gastric Cancer. Yonsei medical journal 7 30450850
1995 Molecular cloning and sequence of the cytoplasmic ribosomal protein S15a gene from Agaricus bisporus. Experimental mycology 6 7614376
2023 FOXN3 inhibits the progression of ovarian cancer through negatively regulating the expression of RPS15A. Human cell 5 37016167
2023 MicroRNA-147b induces neuroendocrine differentiation of prostate cancer cells by targeting ribosomal protein RPS15A. The Prostate 5 37069746
2018 Knockdown of ribosomal protein S15A inhibits human kidney cancer cell growth in vitro and in vivo. Molecular medicine reports 5 30569143
2017 The uS8, uS4, eS31, and uL14 Ribosomal Protein Genes Are Dysregulated in Nasopharyngeal Carcinoma Cell Lines. BioMed research international 5 28791303
2025 GGCT Inhibits Ferroptosis in PTC Cells by Upregulating p53 Through RPS15A. Cancer science 4 40044122
2021 Ribosomal protein RPS15A augments proliferation of colorectal cancer RKO cells via regulation of BIRC3, p38 MAPK and Chk1. European review for medical and pharmacological sciences 4 34156695
2017 Deletion of the us7 and us8 genes of pseudorabies virus exerts a differential effect on the expression of early and late viral genes. Virus genes 4 28477233
2011 Mutation of glutamine to arginine at position 548 of IE2 86 in human cytomegalovirus leads to decreased expression of IE2 40, IE2 60, UL83, and UL84 and increased transcription of US8-9 and US29-32. Journal of virology 4 21865379
2010 Characterization of duck enteritis virus US6, US7 and US8 gene. Intervirology 4 20090359
2025 RPS15a knockdown impedes the progression of B-ALL by inducing p53-mediated nucleolar stress. Biochemical and biophysical research communications 3 40239541
2023 RPS15A Mediates PI3K/AKT Signaling-Induced Parathyroid Cell Proliferation in Rats with Secondary Hyperparathyroidism. Annals of clinical and laboratory science 2 37094854
2022 Ancestral Sequence Reconstruction of the Ribosomal Protein uS8 and Reduction of Amino Acid Usage to a Smaller Alphabet. Journal of molecular evolution 1 36396786
2026 Ochratoxin A drives hepatocellular carcinoma progression via GRPR-mediated activation of PLCβ/IP3R/Ca²⁺ and RPS15A/p53 pathways by regulating cancer cell fate. Ecotoxicology and environmental safety 0 41653713
2025 Long noncoding RNA RHPN1-AS1 promotes hepatocellular carcinoma progression under hypoxia through interaction with RPS15A protein. Medical oncology (Northwood, London, England) 0 41026296
2004 Radiosensitization of a human soft tissue sarcoma cell line US8-93 (mt-p53) with the oxidizer sodium peroxodisulfate. Oncology reports 0 15375518