Affinage

RPS15A

Small ribosomal subunit protein uS8 · UniProt P62244

Length
130 aa
Mass
14.8 kDa
Annotated
2026-06-10
45 papers in source corpus 22 papers cited in narrative 22 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 4/5 claims corpus-supported (80%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPS15A is a small (40S) ribosomal subunit protein whose core RNA-binding activity is evolutionarily conserved as the uS8 family member, retaining RNA binding even when reconstructed from a simplified amino acid alphabet (PMID:36396786), and whose depletion in cancer cells impairs synthesis and processing of pre-rRNA and mature 18S/28S/5.8S rRNAs, disrupts nucleolar architecture, and triggers a p53/p21-dependent nucleolar stress response (PMID:40239541). Beyond this ribosomal role, RPS15A functions as a recurrently overexpressed pro-proliferative and pro-survival node across diverse carcinomas, where its knockdown consistently induces G0/G1 arrest and apoptosis (PMID:24334120, PMID:25833696, PMID:27130037, PMID:29802490). Mechanistically, RPS15A activates Wnt/β-catenin signaling — in HCC it drives FGF18 expression to promote tumor angiogenesis via endothelial FGFR3/AKT/ERK (PMID:29242604), and β-catenin activation also operates in pancreatic and NSCLC contexts (PMID:30831090, PMID:31665807) — and engages survival pathways including Akt, the Akt/IKK-β/NF-κB axis driving EMT in gastric cancer (PMID:26537582, PMID:30661291), and SMAD3 nuclear translocation (PMID:37378633). RPS15A also restrains p53: its loss elevates p53 to suppress SLC7A11 and promote ferroptosis (PMID:40044122), and RPS15A recruits MDM2 to accelerate p53 degradation, thereby sustaining the SLC7A11/GPX4 anti-ferroptosis axis (PMID:41653713). RPS15A protein levels are set post-translationally by FBXL18, which catalyzes stabilizing K63-linked ubiquitination (PMID:37378633), by interacting stabilizers GGCT, GRPR, and the lncRNA RHPN1-AS1 (PMID:40044122, PMID:41653713, PMID:41026296), and are constrained transcriptionally by FOXN3 (PMID:37016167) and post-transcriptionally by miR-29a-3p, miR-147b, and miR-519d-3p (PMID:31303129, PMID:37069746, PMID:30831090).

Mechanistic history

Synthesis pass · year-by-year structured walk · 11 steps
  1. 2004 Medium

    Established RPS15A as a candidate oncogenic effector rather than a passive housekeeping ribosomal protein, by linking it to a viral oncoprotein and demonstrating transforming activity.

    Evidence HBxAg-induced expression with overexpression driving soft-agar colony formation and SCID mouse tumors

    PMID:15108328

    Open questions at the time
    • Did not separate ribosomal from non-ribosomal contributions to transformation
    • No molecular pathway mapped
  2. 2015 Medium

    Defined the cellular consequence of RPS15A loss across tumor types as proliferation arrest at G0/G1, and first implicated p53 and AKT as responsive pathways.

    Evidence shRNA/siRNA knockdown with cell cycle flow cytometry, microarray (p53), and Western blot for p-Akt in hepatic, lung, and glioblastoma cells, including xenografts

    PMID:24334120 PMID:25833696 PMID:26537582

    Open questions at the time
    • Pathway readouts correlative, not reconstituted
    • Causal ordering of p53 vs AKT not resolved
  3. 2017 Medium

    Connected RPS15A to Wnt/β-catenin signaling and a secreted angiogenic program, explaining how an intracellular ribosomal protein influences the tumor microenvironment.

    Evidence HCC overexpression/knockdown with endothelial co-culture angiogenesis, Western blot of Wnt/β-catenin→FGF18→FGFR3/AKT/ERK, and xenograft angiogenesis

    PMID:29242604

    Open questions at the time
    • Direct mechanism by which RPS15A activates β-catenin unknown
    • Whether FGF18 induction is transcriptional or translational not defined
  4. 2019 Medium

    Expanded the downstream signaling repertoire to the Akt/IKK-β/NF-κB EMT axis and confirmed β-catenin activation in additional cancers.

    Evidence Overexpression/knockdown with NF-κB luciferase reporter, p65 translocation, pharmacological inhibition (LY294002, Bay117082), and β-catenin Western blot in gastric, pancreatic, and breast cancer

    PMID:30661291 PMID:30831090 PMID:31535410

    Open questions at the time
    • Multiple parallel pathways reported without a unifying upstream mechanism
    • Direct vs indirect engagement of each kinase unresolved
  5. 2019 Low

    Placed RPS15A within regulatory miRNA networks, identifying it as a direct 3'UTR target whose restoration rescues miRNA-driven tumor suppression.

    Evidence miRNA mimic overexpression with RPS15A rescue and luciferase 3'UTR reporters for miR-29a-3p, miR-147b, and miR-519d-3p in colorectal, NSCLC, and pancreatic cancer

    PMID:30831090 PMID:31303129 PMID:31665807

    Open questions at the time
    • Some reports lack direct luciferase confirmation
    • Endogenous miRNA stoichiometry and tissue specificity not addressed
  6. 2021 Medium

    Positioned RPS15A as a shared downstream effector node receiving inputs from upstream oncogenic regulators (TMED3, PSMC2).

    Evidence Double-knockdown epistasis (TMED3/RPS15A) and PSMC2/let-7c-3p/RPS15A/mTOR rescue with dual-luciferase and Torin1 in osteosarcoma and gastric cancer

    PMID:34838013 PMID:35256584

    Open questions at the time
    • Whether interactions are direct or transcriptional not fully resolved
    • mTOR linkage mechanism (ribosomal vs signaling) unclear
  7. 2023 High

    Identified the post-translational control of RPS15A abundance, showing K63-linked ubiquitination by FBXL18 stabilizes the protein and couples it to SMAD3 signaling.

    Evidence Co-IP, K63 ubiquitination assays, SMAD3 nuclear translocation Western blot, knockdown rescue, and FBXL18 transgenic mice in HCC

    PMID:37378633

    Open questions at the time
    • Ubiquitination site on RPS15A not mapped
    • Mechanism linking stabilized RPS15A to SMAD3 induction not defined
  8. 2023 Medium

    Established transcriptional repression of RPS15A by FOXN3, defining a promoter-level brake on its oncogenic expression.

    Evidence ChIP and dual-luciferase at defined promoter sites with RPS15A rescue in ovarian cancer

    PMID:37016167

    Open questions at the time
    • Whether FOXN3 regulation operates in other tissues unknown
  9. 2025 Medium

    Demonstrated that RPS15A loss is sensed as nucleolar stress, mechanistically anchoring its p53-dependent phenotype to impaired ribosome biogenesis.

    Evidence shRNA knockdown with pre-rRNA/mature rRNA processing assays, NPM1/FBL immunofluorescence, p53/p21 Western blot, and p53 knockdown rescue in B-ALL

    PMID:40239541

    Open questions at the time
    • Direct trigger linking RPS15A depletion to p53 stabilization (e.g. RP-MDM2 sequestration) not biochemically defined here
  10. 2025 Medium

    Linked RPS15A to ferroptosis control and identified interacting protein stabilizers, showing RPS15A suppresses p53 to maintain the SLC7A11/GPX4 anti-ferroptosis axis.

    Evidence Co-IP/LC-MS/MS identifying GGCT and GRPR, MDM2-recruitment p53 degradation, SLC7A11/GPX4 Western blot, ROS/MDA assays, and rescue in thyroid and hepatocellular cancer; lncRNA RHPN1-AS1 stabilization with β-catenin readout

    PMID:40044122 PMID:41026296 PMID:41653713

    Open questions at the time
    • How RPS15A recruits MDM2 mechanistically unknown
    • RHPN1-AS1 interaction not rigorously characterized biochemically
  11. 2022 Medium

    Confirmed the conserved RNA-binding activity of the uS8/RPS15A protein family is robust and reducible to a minimal amino acid composition.

    Evidence Ancestral sequence reconstruction with in vitro RNA-binding and thermal stability assays on the uS8 ortholog

    PMID:36396786

    Open questions at the time
    • Performed on bacterial/ancestral ortholog, not human RPS15A
    • Does not address signaling functions

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved how a single ribosomal protein mechanistically activates such diverse signaling pathways (Wnt, AKT/NF-κB, SMAD3, p53/MDM2) and whether these reflect direct protein interactions, translational regulation of specific mRNAs, or extra-ribosomal moonlighting.
  • No structural or biochemical basis for RPS15A engaging signaling effectors
  • Ribosomal vs extra-ribosomal contributions to oncogenesis not separated
  • Direct interaction map of RPS15A signaling partners incomplete

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 1 GO:0005198 structural molecule activity 1
Localization
GO:0005730 nucleolus 1 GO:0005840 ribosome 1
Pathway
R-HSA-1640170 Cell Cycle 3 R-HSA-162582 Signal Transduction 2 R-HSA-5357801 Programmed Cell Death 2 R-HSA-8953854 Metabolism of RNA 1
Partners
FBXL18GGCTGRPRMDM2RHPN1-AS1SMAD3
Complex memberships
40S ribosomal subunit

Evidence

Reading pass · 22 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2004 HBV X antigen (HBxAg) upregulates RPS15A/S15a expression; overexpression of S15a stimulated cell growth, colony formation in soft agar, and tumor formation in SCID mice, indicating S15a participates in HCC development by altering translation integrity. PCR select cDNA subtraction, Northern and Western blotting, overexpression in cell lines, soft-agar colony formation, SCID mouse tumor formation assay Molecular carcinogenesis Medium 15108328
2013 Knockdown of RPS15A with shRNA inhibits hepatic cancer cell proliferation, impairs colony formation, and induces G0/G1 cell cycle arrest in HepG2 and Bel7404 cells, establishing a role for RPS15A in supporting cancer cell cycle progression. Lentiviral shRNA knockdown, MTT/colony formation assays, flow cytometric cell cycle analysis Gene Medium 24334120
2015 RPS15A knockdown inhibits proliferation and induces G0/G1 cell cycle arrest in lung adenocarcinoma A549 cells, and RPS15A knockdown activates the p53 signaling pathway as revealed by gene expression profiling. siRNA knockdown, MTT assay, colony formation assay, flow cytometry, gene expression microarray Tumour biology Medium 25833696
2015 RPS15A knockdown in glioblastoma cells inhibits proliferation and migration, reduces p-Akt levels, and causes G0/G1 cell cycle arrest in vitro; knockdown also inhibits xenograft tumor growth in vivo, placing RPS15A upstream of the AKT pathway. Lentiviral RNAi knockdown, MTT assay, wound healing, transwell migration, Western blot (p-Akt), flow cytometry, nude mouse xenograft Tumour biology Medium 26537582
2016 RPS15A knockdown in glioblastoma U251 cells inhibits proliferation, induces G0/G1 arrest and apoptosis; mechanistically, knockdown suppresses Bcl-2 and activates caspase-3 and PARP cleavage. Lentiviral RNAi, MTT assay, colony formation, flow cytometry, Western blot (Bcl-2, caspase-3, PARP) World journal of surgical oncology Medium 27130037
2017 RPS15A promotes tumor angiogenesis in HCC by enhancing Wnt/β-catenin-mediated FGF18 expression; FGF18 then binds FGFR3 on endothelial cells to activate AKT and ERK pathways. RPS15A overexpression increased HUVEC angiogenic potential in co-culture; knockdown had the opposite effect. In vivo, RPS15A inhibition hindered xenograft tumor growth and angiogenesis. HCC cell line overexpression and knockdown (Huh7, HepG2), endothelial co-culture angiogenesis assay, Western blot (Wnt/β-catenin, FGF18, p-AKT, p-ERK), xenograft mouse model Oncogene Medium 29242604
2018 RPS15A knockdown in breast cancer cells (ZR-75-30, BT474) inhibits proliferation, induces G0/G1 arrest and apoptosis; apoptosis is mediated by caspase-3 activation, PARP cleavage, upregulation of Bad and BAX, and downregulation of Bcl-2. Lentiviral shRNA knockdown, MTT assay, colony formation, flow cytometry, Western blot Cytotechnology Medium 29802490
2019 RPS15A activates the NF-κB pathway via the Akt/IKK-β signaling axis in gastric cancer cells, promoting nuclear translocation and phosphorylation of p65 NF-κB, transactivation of NF-κB reporter genes, and EMT. Both Akt inhibitor LY294002 and IKK inhibitor Bay117082 neutralized RPS15A-induced p65 nuclear translocation. RPS15A overexpression and knockdown in GC cell lines, NF-κB luciferase reporter, Western blot (p65, p-p65, p-Akt, p-IKK-β), pharmacological inhibition, in vivo xenograft Journal of cellular and molecular medicine Medium 30661291
2019 RPS15A knockdown downregulates β-catenin expression and blocks Wnt signaling activation in pancreatic cancer cells; miR-519d-3p directly targets RPS15A 3'UTR to negatively regulate its expression, and restoration of RPS15A partially reverses the antitumor effect of miR-519d-3p. siRNA knockdown, miRNA mimic overexpression, luciferase reporter assay (3'UTR), Western blot (β-catenin), proliferation and colony formation assays Chemico-biological interactions Medium 30831090
2019 RPS15A knockdown in breast cancer MDA-MB-231 cells suppresses phosphorylated ERK1/2, Bad, and Chk1 levels and promotes apoptosis, identifying these kinase substrates as downstream effectors of RPS15A-mediated survival signaling. Lentiviral shRNA knockdown, Western blot (p-ERK1/2, p-Bad, p-Chk1), caspase-3/-7 activity assay, flow cytometry Journal of cellular biochemistry Low 31535410
2019 miR-29a-3p directly targets the 3'UTR of RPS15A; restoration of RPS15A rescues the phenotypic changes (cell cycle arrest, apoptosis, altered CDK4/Cyclin D1/p21 levels) caused by miR-29a-3p overexpression in colorectal cancer cells. miRNA mimic overexpression, RPS15A rescue, Western blot, flow cytometry, luciferase reporter (implied by target validation language) Bioscience, biotechnology, and biochemistry Low 31303129
2019 miR-147b directly targets RPS15A in NSCLC; RPS15A acts downstream of miR-147b to drive Wnt/β-catenin signaling, and overexpression of RPS15A partially reverses the antitumor effect of miR-147b overexpression. miR-147b overexpression, RPS15A rescue, proliferation/invasion assays, Western blot (Wnt/β-catenin), correlation in clinical specimens Clinical and experimental pharmacology & physiology Low 31665807
2021 TMED3 knockdown inhibits osteosarcoma progression, and RPS15A is a downstream target of TMED3; simultaneous knockdown of RPS15A and TMED3 intensifies inhibitory effects, while RPS15A knockdown alleviates the promotion of TMED3 overexpression, establishing RPS15A as a downstream effector of TMED3. shRNA knockdown of TMED3 and RPS15A, gene expression profiling, rescue/epistasis experiments, in vitro proliferation/migration/apoptosis assays, xenograft model Cancer cell international Medium 34838013
2022 PSMC2 promotes RPS15A expression by competitively binding to hsa-let-7c-3p; PSMC2 knockdown inhibits RPS15A expression and mTOR pathway activation, which is neutralized by RPS15A overexpression; RPS15A overexpression rescues PSMC2-KD-induced mTOR suppression, placing RPS15A downstream of PSMC2 in the PSMC2/let-7c-3p/RPS15A/mTOR axis in gastric cancer. GeneChip expression profiling, IPA pathway analysis, RPS15A overexpression rescue, dual-luciferase reporter assay (hsa-let-7c-3p competitive binding), mTOR inhibitor (Torin1), cell function assays Oncogenesis Medium 35256584
2023 FBXL18 E3 ubiquitin ligase promotes K63-linked ubiquitination of RPS15A, enhancing its protein stability; stabilized RPS15A increases SMAD3 levels and promotes its nuclear translocation, driving HCC cell proliferation. Knockdown of RPS15A or SMAD3 suppresses FBXL18-mediated HCC proliferation. Co-immunoprecipitation, ubiquitination assays (K63 linkage), Western blot (SMAD3 nuclear translocation), RPS15A/SMAD3 knockdown rescue, FBXL18 transgenic mice, clinical sample correlation Hepatology communications High 37378633
2023 FOXN3 transcription factor binds to the RPS15A promoter (at positions −1588/−1581 and −1476/−1467) and directly inhibits RPS15A transcriptional expression; RPS15A overexpression reverses FOXN3-mediated suppression of ovarian cancer malignant behaviors. Dual-luciferase reporter assay, chromatin immunoprecipitation (ChIP), RPS15A overexpression rescue, cell proliferation/invasion/migration/angiogenesis assays Human cell Medium 37016167
2023 miR-147b directly targets RPS15A in prostate cancer cells; RPS15A expression is inversely correlated with NE markers in NEPC; overexpression of miR-147b reduces RPS15A and induces neuroendocrine differentiation, with elevated p27kip1 and reduced cyclin D1 mediating reduced proliferation. miRNA mimic/inhibitor transfection, luciferase reporter assay (RPS15A 3'UTR), Western blot (NE markers, cyclin D1, p27kip1), qRT-PCR The Prostate Medium 37069746
2025 RPS15A knockdown in B-ALL cells impairs rRNA synthesis and processing (pre-rRNA, 18S, 28S, 5.8S rRNA), disrupts nucleolar architecture (NPM1 and FBL localization), induces nucleolar stress, and activates p53/p21 signaling; p53 knockdown rescues ribosomal biogenesis defects and restores cell cycle progression, placing RPS15A upstream of p53-mediated nucleolar stress. shRNA knockdown, rRNA processing assays (RT-qPCR for pre-rRNA/mature rRNAs), immunofluorescence (NPM1, FBL), Western blot (p53, p21), p53 KD rescue experiment, flow cytometry Biochemical and biophysical research communications Medium 40239541
2025 GGCT interacts with RPS15A (identified by co-immunoprecipitation and LC-MS/MS) and promotes RPS15A protein stability; RPS15A knockdown elevates p53 expression, which inhibits SLC7A11, reducing GSH synthesis and promoting ferroptosis in papillary thyroid cancer cells; RPS15A overexpression reverses GGCT-knockdown-induced ferroptosis. Co-immunoprecipitation combined with LC-MS/MS, shRNA knockdown of RPS15A, RPS15A overexpression rescue, Western blot (p53, SLC7A11, GPX4), MDA/ROS measurement, subcutaneous tumor formation assay Cancer science Medium 40044122
2025 RHPN1-AS1 lncRNA interacts with and stabilizes RPS15A protein in hypoxic HCC cells; elevated RPS15A activates β-catenin signaling to promote HCC cell proliferation and invasion; RPS15A silencing attenuates RHPN1-AS1-induced aggressiveness and β-catenin activation in vitro and in vivo. RNA-protein interaction assay (RHPN1-AS1/RPS15A), RPS15A knockdown rescue, Western blot (β-catenin), proliferation/invasion assays, xenograft mouse model Medical oncology Low 41026296
2026 Co-immunoprecipitation coupled with mass spectrometry identified RPS15A as a novel GRPR-interacting protein; RPS15A overexpression promotes HCC progression by recruiting MDM2 to accelerate p53 degradation, thereby upregulating the SLC7A11/GPX4 anti-ferroptosis axis. Co-immunoprecipitation/mass spectrometry, molecular docking, surface plasmon resonance, RPS15A overexpression, functional rescue experiments, in vitro and in vivo assays Ecotoxicology and environmental safety Medium 41653713
2022 Ancestral variants of the ribosomal protein uS8 (RPS15A ortholog) reconstructed from reduced amino acid alphabets (down to 13 amino acids) retained RNA-binding activity, demonstrating that the RNA-binding function of uS8 is achievable with a simplified amino acid composition; thermal stability was lost at 13-letter alphabet but RNA binding was retained. Ancestral sequence reconstruction, phylogenetic analysis, thermal stability assays, RNA-binding assays (in vitro) Journal of molecular evolution Medium 36396786

Source papers

Stage 0 corpus · 45 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2017 Ribosomal protein S15a promotes tumor angiogenesis via enhancing Wnt/β-catenin-induced FGF18 expression in hepatocellular carcinoma. Oncogene 62 29242604
2019 HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways. Nature communications 45 31604943
2019 RPS15A promotes gastric cancer progression via activation of the Akt/IKK-β/NF-κB signalling pathway. Journal of cellular and molecular medicine 39 30661291
1992 Cytoplasmic ribosomal protein S15a from Brassica napus: molecular cloning and developmental expression in mitotically active tissues. Plant molecular biology 39 1581568
2002 Human cytomegalovirus US7, US8, US9, and US10 are cytoplasmic glycoproteins, not found at cell surfaces, and US9 does not mediate cell-to-cell spread. Journal of virology 38 11992003
2013 Down-regulation of ribosomal protein S15A mRNA with a short hairpin RNA inhibits human hepatic cancer cell growth in vitro. Gene 37 24334120
2004 Human S15a expression is upregulated by hepatitis B virus X protein. Molecular carcinogenesis 30 15108328
2015 Decreased expression of RPS15A suppresses proliferation of lung cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 29 25833696
2015 Down-regulation of ribosomal protein S15A inhibits proliferation of human glioblastoma cells in vivo and in vitro via AKT pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 28 26537582
2022 PSMC2 promotes the progression of gastric cancer via induction of RPS15A/mTOR pathway. Oncogenesis 26 35256584
2019 Overexpression of microRNA-519d-3p suppressed the growth of pancreatic cancer cells by inhibiting ribosomal protein S15A-mediated Wnt/β-catenin signaling. Chemico-biological interactions 26 30831090
2002 The human cytomegalovirus US8 glycoprotein binds to major histocompatibility complex class I products. Journal of virology 26 12050396
2019 Construction of a US7/US8/UL23/US3-deleted recombinant pseudorabies virus and evaluation of its pathogenicity in dogs. Veterinary microbiology 24 31902487
2016 Knockdown of ribosomal protein S15A induces human glioblastoma cell apoptosis. World journal of surgical oncology 20 27130037
2014 Ribosomal protein S15A augments human osteosarcoma cell proliferation in vitro. Cancer biotherapy & radiopharmaceuticals 19 25409460
2019 Downregulation of RPS15A by miR-29a-3p attenuates cell proliferation in colorectal carcinoma. Bioscience, biotechnology, and biochemistry 17 31303129
2016 The effect of ribosomal protein S15a in lung adenocarcinoma. PeerJ 16 26989627
2021 TMED3/RPS15A Axis promotes the development and progression of osteosarcoma. Cancer cell international 15 34838013
1995 Characterization of the US8.5 protein of herpes simplex virus. Archives of virology 15 8572943
2019 MicroRNA-147b suppresses the proliferation and invasion of non-small-cell lung cancer cells through downregulation of Wnt/β-catenin signalling via targeting of RPS15A. Clinical and experimental pharmacology & physiology 14 31665807
1997 Nucleotide sequence of canine herpesvirus homologues of herpes simplex virus type 1 US2, US3, glycoproteins I and E, US8.5 and US9 genes. DNA sequence : the journal of DNA sequencing and mapping 14 9524817
2018 Knockdown of ribosomal protein S15A inhibits proliferation of breast cancer cells through induction of apoptosis in vitro. Cytotechnology 13 29802490
2023 Elevated FBXL18 promotes RPS15A ubiquitination and SMAD3 activation to drive HCC. Hepatology communications 12 37378633
2016 shRNA-mediated RPS15A silencing inhibits U937 acute myeloid leukemia cell proliferation and enhances apoptosis. Molecular medicine reports 12 27035327
1994 The primary structure of rat ribosomal protein S15a. Biochemical and biophysical research communications 11 8185605
2019 Ribosomal protein small subunit 15A (RPS15A) inhibits the apoptosis of breast cancer MDA-MB-231 cells via upregulating phosphorylated ERK1/2, Bad, and Chk1. Journal of cellular biochemistry 9 31535410
2004 Cloning, expression and partial characterization of a gene encoding the S15a ribosomal protein of Taenia solium. Parasitology research 9 14760523
2017 MicroRNA-29 family functions as a tumor suppressor by targeting RPS15A and regulating cell cycle in hepatocellular carcinoma. International journal of clinical and experimental pathology 8 31966655
2018 RPS15a Silencing Suppresses Cell Proliferation and Migration of Gastric Cancer. Yonsei medical journal 7 30450850
2023 FOXN3 inhibits the progression of ovarian cancer through negatively regulating the expression of RPS15A. Human cell 6 37016167
1995 Molecular cloning and sequence of the cytoplasmic ribosomal protein S15a gene from Agaricus bisporus. Experimental mycology 6 7614376
2025 GGCT Inhibits Ferroptosis in PTC Cells by Upregulating p53 Through RPS15A. Cancer science 5 40044122
2023 MicroRNA-147b induces neuroendocrine differentiation of prostate cancer cells by targeting ribosomal protein RPS15A. The Prostate 5 37069746
2018 Knockdown of ribosomal protein S15A inhibits human kidney cancer cell growth in vitro and in vivo. Molecular medicine reports 5 30569143
2017 The uS8, uS4, eS31, and uL14 Ribosomal Protein Genes Are Dysregulated in Nasopharyngeal Carcinoma Cell Lines. BioMed research international 5 28791303
2021 Ribosomal protein RPS15A augments proliferation of colorectal cancer RKO cells via regulation of BIRC3, p38 MAPK and Chk1. European review for medical and pharmacological sciences 4 34156695
2017 Deletion of the us7 and us8 genes of pseudorabies virus exerts a differential effect on the expression of early and late viral genes. Virus genes 4 28477233
2011 Mutation of glutamine to arginine at position 548 of IE2 86 in human cytomegalovirus leads to decreased expression of IE2 40, IE2 60, UL83, and UL84 and increased transcription of US8-9 and US29-32. Journal of virology 4 21865379
2010 Characterization of duck enteritis virus US6, US7 and US8 gene. Intervirology 4 20090359
2025 RPS15a knockdown impedes the progression of B-ALL by inducing p53-mediated nucleolar stress. Biochemical and biophysical research communications 3 40239541
2023 RPS15A Mediates PI3K/AKT Signaling-Induced Parathyroid Cell Proliferation in Rats with Secondary Hyperparathyroidism. Annals of clinical and laboratory science 2 37094854
2022 Ancestral Sequence Reconstruction of the Ribosomal Protein uS8 and Reduction of Amino Acid Usage to a Smaller Alphabet. Journal of molecular evolution 1 36396786
2026 Ochratoxin A drives hepatocellular carcinoma progression via GRPR-mediated activation of PLCβ/IP3R/Ca²⁺ and RPS15A/p53 pathways by regulating cancer cell fate. Ecotoxicology and environmental safety 0 41653713
2025 Long noncoding RNA RHPN1-AS1 promotes hepatocellular carcinoma progression under hypoxia through interaction with RPS15A protein. Medical oncology (Northwood, London, England) 0 41026296
2004 Radiosensitization of a human soft tissue sarcoma cell line US8-93 (mt-p53) with the oxidizer sodium peroxodisulfate. Oncology reports 0 15375518

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