Affinage

RPS14

Small ribosomal subunit protein uS11 · UniProt P62263

Length
151 aa
Mass
16.3 kDa
Annotated
2026-06-10
100 papers in source corpus 14 papers cited in narrative 14 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 4/4 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPS14 is a structural protein of the small (40S) ribosomal subunit and a determinant of ribosome biogenesis required for erythroid differentiation (PMID:18202658, PMID:3865384). As a core 40S component, RPS14 (yeast rpS14) binds helix 23 of 18S rRNA through conserved surface residues and a basic C-terminal tail, and the same protein autoregulates its own expression by binding a stem-loop in its pre-mRNA (PMID:14568531); its incorporation into the small subunit further depends on a transient, NTPase-dependent contact with Fap7 that drives cytoplasmic cleavage of 20S pre-rRNA to mature 18S rRNA (PMID:16287850). RPS14 haploinsufficiency blocks pre-rRNA processing and arrests erythroid maturation in a p53-dependent manner, and is the causal lesion underlying the erythroid defect of 5q- myelodysplastic syndrome, as loss-of-function phenocopies the disease and forced expression rescues patient cells (PMID:18202658, PMID:26878232). Downstream of this defect, RPS14 deficiency induces the innate immune proteins S100A8/S100A9—sufficient and necessary for the erythroid block both cell-intrinsically and via the marrow niche (PMID:26878232, PMID:30651631)—and reprograms translation to disfavor short, high-CAI, structured-3'UTR transcripts needed for erythropoiesis under limiting ribosome availability (PMID:32327500).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1985 Medium

    Establishing that the human chromosome 5 RPS14 gene is the structural gene for ribosomal protein S14 anchored RPS14 as a bona fide ribosome component before any disease link existed.

    Evidence human-Chinese hamster cell hybrids with ribosomal protein fractionation and electrophoretic identification of human S14 in ribosomes

    PMID:3865384 PMID:9732752

    Open questions at the time
    • did not define RNA-binding residues or assembly mechanism
    • no link to erythropoiesis or disease yet
  2. 1995 Medium

    Showed that RPS14 protein autoregulates its own gene, revealing a feedback role beyond passive ribosome incorporation.

    Evidence cell-free transcription, transfection, and EMSA demonstrating RPS14 protein, its mRNA, and intronic antisense RNAs in direct binary interactions

    PMID:7867928

    Open questions at the time
    • mechanism of antisense-RNA positive regulation unresolved
    • structural basis of protein-RNA contacts not defined
  3. 2003 High

    Resolved how a single ribosomal protein discriminates two RNA targets, defining the residues used for 40S assembly versus autoregulation.

    Evidence structure-guided alanine-scanning mutagenesis of yeast rpS14 with in vitro RNA binding, 40S assembly, and pre-mRNA repression assays

    PMID:14568531

    Open questions at the time
    • human RPS14 residue contacts inferred from yeast
    • no structure of RPS14 within the human 40S
  4. 2005 High

    Identified the trans-acting factor (Fap7) that uses RPS14 as a docking point to complete cytoplasmic 18S rRNA maturation, placing RPS14 mechanistically within the late ribosome assembly pathway.

    Evidence Fap7 depletion, direct Fap7-Rps14 binding assay, and NTPase active-site mutagenesis with pre-rRNA processing analysis in yeast

    PMID:16287850

    Open questions at the time
    • human ortholog interaction not directly demonstrated
    • structural details of the Fap7-RPS14 contact unknown
  5. 2008 High

    Connected RPS14 directly to disease, showing its haploinsufficiency causes the 5q- syndrome erythroid defect through impaired pre-rRNA processing.

    Evidence RNAi knockdown in primary hematopoietic progenitors, pre-rRNA processing assay, and rescue by forced expression in patient bone marrow cells

    PMID:18202658

    Open questions at the time
    • downstream effectors of the differentiation block not yet identified
    • mechanism distinguishing erythroid lineage sensitivity unclear
  6. 2016 High

    Defined the downstream effector pathway, showing the erythroid block is p53-dependent and mediated by S100A8/S100A9 induction.

    Evidence conditional Rps14 knockout mice, quantitative proteomics, recombinant S100A8 treatment, and genetic S100a8-knockout rescue

    PMID:26878232

    Open questions at the time
    • how RPS14 loss triggers S100A8 induction not fully resolved
    • link between p53 activation and S100A8 upregulation undefined
  7. 2016 Medium

    Showed erythroid failure downstream of RPS14 loss proceeds in two phases, initially p53-independent then p53-dependent.

    Evidence CRISPR/Cas9 rps14 knockout in zebrafish with p53 pathway analysis and pharmacological rescue

    PMID:27216296

    Open questions at the time
    • molecular driver of the early p53-independent phase unidentified
    • relevance of two-phase model to mammalian disease untested
  8. 2019 Medium

    Extended the mechanism to the marrow microenvironment and to combinatorial 5q- gene loss, establishing an extrinsic, niche-mediated arm of RPS14 haploinsufficiency.

    Evidence combinatorial conditional mouse knockouts (Rps14/Csnk1a1/miR-145/146a) with bone marrow transplantation and niche S100A8 expression analysis

    PMID:30651631

    Open questions at the time
    • relative contribution of intrinsic vs niche S100A8 unquantified
    • single-gene Rps14 contribution within the combination not isolated
  9. 2019 Medium

    Identified an MMP9-TGF-β signaling axis as an additional route by which RPS14 deficiency impairs erythropoiesis.

    Evidence RPS14 knockdown in zebrafish and human CD34+ cells, recombinant MMP9, SMAD2/3 phosphorylation assays, and MMP9 inhibitor rescue

    PMID:31540902

    Open questions at the time
    • integration of the MMP9-TGF-β axis with the S100A8/p53 pathway unclear
    • no human in vivo validation
  10. 2021 Medium

    Explained lineage selectivity at the translational level, showing limiting ribosome availability differentially impairs transcripts with features shared by erythroid-required proteins.

    Evidence ribosome profiling and quantitative proteomics in RPS14-knockdown erythroid cells

    PMID:32327500

    Open questions at the time
    • causal test that restoring these transcripts rescues differentiation absent
    • interaction with S100A8/p53 pathway not addressed
  11. 2023 Low

    Reported post-translational control of RPS14 stability via STUB1-mediated ubiquitination at K125 in a non-hematopoietic (chondrocyte) context.

    Evidence RNA pulldown, RIP, ubiquitination assay, and K125 site-specific mutagenesis in a circZSWIM6 study

    PMID:36604982

    Open questions at the time
    • single lab, limited mechanistic depth on RPS14 itself
    • relevance of STUB1-RPS14 axis to erythropoiesis untested
    • no reciprocal validation in hematopoietic cells
  12. 2023 Low

    Suggested a gain-of-function developmental role for RPS14 in cochlear hair cell regeneration via Wnt signaling.

    Evidence AAV-mediated Rps14 overexpression in neonatal mouse cochlea with lineage tracing and Wnt reporter analysis

    PMID:36977657

    Open questions at the time
    • no loss-of-function controls reported
    • mechanism linking RPS14 to Wnt activation undefined
    • may reflect general ribosome dosage rather than specific RPS14 function

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RPS14 haploinsufficiency mechanistically triggers p53 activation, S100A8 induction, and translational selectivity—and whether these arms are unified or parallel—remains unresolved.
  • no single model integrates p53, S100A8/S100A9, MMP9-TGF-β, and translation-selectivity arms
  • structural basis of human RPS14 within the 40S not determined
  • why the erythroid lineage is uniquely sensitive remains unexplained

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 2 GO:0005198 structural molecule activity 2
Localization
GO:0005840 ribosome 2 GO:0005829 cytosol 1
Pathway
R-HSA-8953854 Metabolism of RNA 3 R-HSA-1643685 Disease 2 R-HSA-392499 Metabolism of proteins 2
Partners
ALG-1FAP7STUB1
Complex memberships
40S ribosomal subunit

Evidence

Reading pass · 14 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2008 Partial loss of function of RPS14 (ribosomal protein S14) by RNAi phenocopies the 5q- syndrome erythroid differentiation defect in normal haematopoietic progenitor cells, and forced RPS14 expression rescues the disease phenotype in patient-derived bone marrow cells. RPS14 deficiency causes a block in pre-ribosomal RNA processing equivalent to that seen in Diamond-Blackfan anaemia, placing RPS14 in the ribosome biogenesis pathway required for erythroid differentiation. RNAi knockdown in primary haematopoietic progenitors, rescue by forced expression in patient-derived cells, pre-rRNA processing assay Nature High 18202658
2016 Conditional inactivation of Rps14 in mice causes a p53-dependent erythroid differentiation block (apoptosis at polychromatic-to-orthochromatic erythroblast transition) that is mechanistically linked to upregulation of S100A8/S100A9. Recombinant S100A8 alone induces the differentiation defect in wild-type erythroid cells, and genetic inactivation of S100a8 rescues the erythroid defect of Rps14-haploinsufficient HSCs, placing S100A8 downstream of Rps14 haploinsufficiency. Conditional Rps14 knockout mice, quantitative proteomics, recombinant S100A8 treatment of wild-type cells, genetic S100a8 knockout rescue Nature medicine High 26878232
2005 The yeast NTPase Fap7 mediates cytoplasmic 20S pre-rRNA cleavage at site D (generating 18S rRNA) through a direct physical interaction with Rps14 (yeast ortholog). Fap7 is not a structural component of pre-ribosomes but transiently contacts them via Rps14, and NTPase-dead Fap7 mutants fail to support 18S rRNA maturation in vivo. Genetic depletion of Fap7, direct binding assay between Fap7 and Rps14, in vivo NTPase active-site mutagenesis, pre-rRNA processing analysis Molecular and cellular biology High 16287850
2003 Yeast ribosomal protein S14 (rpS14) binds two distinct RNA substrates via conserved surface-exposed residues and the basic C-terminal tail: (1) helix 23 of 18S rRNA during 40S subunit assembly, and (2) a stem-loop in RPS14B pre-mRNA to repress its own expression. Alanine mutagenesis of eight conserved residues and the last ten C-terminal residues identified specific contacts required for each interaction and for 40S assembly and autoregulatory repression. Alanine-scanning mutagenesis guided by bacterial S11 crystal structure, RNA-binding assays, 40S subunit assembly assays, pre-mRNA repression assays Journal of molecular biology High 14568531
1995 RPS14 protein negatively regulates transcription of its own gene (RPS14 mRNA), while two intronic antisense RNAs (alpha-250 and alpha-280), transcribed from the antisense strand of RPS14 intron 1, act as positive effectors. Electrophoretic mobility shift assays demonstrated specific binary interactions between RPS14 protein, its mRNA, and the antisense RNAs. Cell-free transcription assay, tissue culture transfection, electrophoretic mobility shift assay (EMSA) Genes & development Medium 7867928
1985 The human RPS14 gene on chromosome 5 is the structural gene for ribosomal protein S14; human S14 protein is incorporated into functional ribosomes in interspecific cell hybrids, as demonstrated by concordant segregation of the gene, emetine-sensitivity phenotype, and electrophoretically distinct human S14 protein from ribosomal fractions. Human-Chinese hamster cell hybrids, ribosomal protein fractionation, electrophoretic analysis of ribosomal proteins Somatic cell and molecular genetics Medium 3865384
1982 The human emtB locus (RPS14) encoding ribosomal protein S14, the leuS gene, and the chr gene are all linked on human chromosome 5 (and conserved on Chinese hamster chromosome 2). Human RPS14 protein is incorporated into functional ribosomes in place of the Chinese hamster ortholog in hybrid cells. Interspecific human-Chinese hamster cell hybrids, chromosomal segregation analysis, complementation of emetine resistance Somatic cell genetics Medium 9732752
2019 Combined haploinsufficiency of Rps14, Csnk1a1, and miR-145/miR-146a in mice recapitulates cardinal features of 5q- syndrome (severe anemia and megakaryocyte dysplasia). Rps14/Csnk1a1/miR-145/146a-deficient macrophages show innate immune activation with increased S100A8 expression and induce S100A8 in the mesenchymal stem cell niche, establishing an extrinsic mechanism by which Rps14 haploinsufficiency alters the bone marrow microenvironment. Conditional heterozygous mouse knockouts combined with miRNA knockdown, bone marrow transplantation, S100A8 expression analysis in niche cells Leukemia Medium 30651631
2021 In RPS14-deficient cells (mimicking 5q- syndrome), translation selectivity is determined by transcript length, codon bias (codon adaptation index) of the CDS, and 3'UTR structure. Short transcripts with structured 3'UTR and high CAI show decreased translation efficiency under low ribosome availability, and proteins required for erythroid differentiation share these determinants, providing a mechanistic basis for impaired erythropoiesis. Ribosome profiling (translatome analysis) combined with quantitative proteomics in RPS14-knockdown erythroid cells Haematologica Medium 32327500
2016 CRISPR/Cas9-mediated disruption of rps14 in zebrafish causes late-stage erythropoietic defects that are initially p53-independent and then become p53-dependent, establishing a two-phase mechanism of erythroid failure downstream of RPS14 loss. CRISPR/Cas9 knockout in zebrafish, p53 pathway analysis, pharmacological rescue assays Journal of genetics and genomics Medium 27216296
2019 MMP9 is upregulated in RPS14-deficient cells via monocyte chemoattractant protein 1, and MMP9 directly activates TGF-β signaling (increased SMAD2/3 phosphorylation) to impair erythroid development. MMP9 inhibition rescues the erythroid defect in rps14-deficient zebrafish and in human RPS14-knockdown CD34+ cells. RPS14 knockdown in zebrafish and human CD34+ cells, recombinant MMP9 treatment, SMAD2/3 phosphorylation assay, MMP9 inhibitor rescue Blood advances Medium 31540902
2009 Ribosomal protein RPS-14 (C. elegans ortholog) modulates let-7 microRNA function: RPS-14 co-immunoprecipitates with the Argonaute homolog ALG-1, and RNAi-mediated reduction of rps-14 suppresses the developmental phenotypes of let-7 loss-of-function mutants and de-represses a let-7 target reporter. Co-immunoprecipitation of RPS-14 with ALG-1, RNAi knockdown, genetic epistasis with let-7 mutants, reporter assay Developmental biology Low 19627982
2023 CircZSWIM6 competitively binds to the E3 ligase STUB1 binding site on RPS14 at lysine K125, inhibiting STUB1-mediated proteasomal degradation of RPS14. Stabilized RPS14 maintains AMPK signaling transduction in chondrocytes. RNA pulldown assay, RIP, ubiquitination assay, site-specific mutagenesis of K125 Clinical and translational medicine Low 36604982
2023 Adeno-associated virus-mediated upregulation of Rps14 in neonatal mouse cochlea promotes Lgr5+ supporting cell proliferation and their differentiation into hair cells via activation of the Wnt signalling pathway. AAV-mediated Rps14 overexpression in vivo, lineage tracing, Wnt pathway reporter analysis Cell proliferation Low 36977657

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1996 The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell 896 8625414
2008 Identification of RPS14 as a 5q- syndrome gene by RNA interference screen. Nature 716 18202658
2016 Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9. Nature medicine 200 26878232
2000 Inhibition of PKR activation by the proline-rich RNA binding domain of the herpes simplex virus type 1 Us11 protein. Journal of virology 177 11070019
2012 Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5. Journal of virology 151 22301138
1998 The herpes simplex virus US11 protein effectively compensates for the gamma1(34.5) gene if present before activation of protein kinase R by precluding its phosphorylation and that of the alpha subunit of eukaryotic translation initiation factor 2. Journal of virology 151 9765401
2012 The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR. Journal of virology 145 23115300
1999 The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate. The Journal of cell biology 135 10508854
1992 The herpes simplex virus 1 RNA binding protein US11 is a virion component and associates with ribosomal 60S subunits. Journal of virology 133 1316472
2002 Herpes simplex virus tegument protein US11 interacts with conventional kinesin heavy chain. Journal of virology 115 11884553
1998 Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11. The Journal of experimental medicine 112 9687527
2001 Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol. Molecular biology of the cell 109 11514634
2002 Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein. Journal of virology 104 12368348
1997 The HCMV gene products US11 and US2 differ in their ability to attack allelic forms of murine major histocompatibility complex (MHC) class I heavy chains. The Journal of experimental medicine 100 9016885
2002 The herpes simplex virus type 1 U(S)11 protein interacts with protein kinase R in infected cells and requires a 30-amino-acid sequence adjacent to a kinase substrate domain. Journal of virology 92 11836380
2007 Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein. Journal of virology 84 17229694
1982 Linkage of the leuS, emtB, and chr genes on chromosome 5 in humans and expression of human genes encoding protein synthetic components in human--Chinese hamster hybrids. Somatic cell genetics 83 9732752
2003 Association of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptides. Journal of virology 82 12915535
2005 The putative NTPase Fap7 mediates cytoplasmic 20S pre-rRNA processing through a direct interaction with Rps14. Molecular and cellular biology 80 16287850
2008 Haploinsufficiency of RPS14 in 5q- syndrome is associated with deregulation of ribosomal- and translation-related genes. British journal of haematology 77 18477045
1999 A single nuclear transcript encoding mitochondrial RPS14 and SDHB of rice is processed by alternative splicing: common use of the same mitochondrial targeting signal for different proteins. Proceedings of the National Academy of Sciences of the United States of America 73 10430921
2001 Ubiquitination is essential for human cytomegalovirus US11-mediated dislocation of MHC class I molecules from the endoplasmic reticulum to the cytosol. The Biochemical journal 71 11513735
1999 The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products. Proceedings of the National Academy of Sciences of the United States of America 70 10411907
1986 The product of gene US11 of herpes simplex virus type 1 is expressed as a true late gene. The Journal of general virology 68 3009688
1991 Replacement mutagenesis of the human cytomegalovirus genome: US10 and US11 gene products are nonessential. Journal of virology 62 1656074
1982 Selective linkage disruption in human-Chinese hamster cell hybrids: deletion mapping of the leuS, hexB, emtB, and chr genes on human chromosome 5. Molecular and cellular biology 62 7177110
2005 Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products. Journal of virology 60 15708995
1996 Structure and function in the herpes simplex virus 1 RNA-binding protein U(s)11: mapping of the domain required for ribosomal and nucleolar association and RNA binding in vitro. Journal of virology 60 8627758
2003 Differential effects of US2, US6 and US11 human cytomegalovirus proteins on HLA class Ia and HLA-E expression: impact on target susceptibility to NK cell subsets. European journal of immunology 58 14515258
2002 Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells. Journal of virology 57 11967320
2002 Characterization of RNA determinants recognized by the arginine- and proline-rich region of Us11, a herpes simplex virus type 1-encoded double-stranded RNA binding protein that prevents PKR activation. Journal of virology 57 12414939
1995 Regulation of human RPS14 transcription by intronic antisense RNAs and ribosomal protein S14. Genes & development 56 7867928
1990 The herpes simplex virus Us11 open reading frame encodes a sequence-specific RNA-binding protein. Journal of virology 56 2161949
2005 Rhesus cytomegalovirus contains functional homologues of US2, US3, US6, and US11. Journal of virology 55 15827193
2001 Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor. The EMBO journal 55 11285222
1987 The products of gene US11 of herpes simplex virus type 1 are DNA-binding and localize to the nucleoli of infected cells. The Journal of general virology 55 3037015
1999 Transfer of rps14 from the mitochondrion to the nucleus in maize implied integration within a gene encoding the iron-sulphur subunit of succinate dehydrogenase and expression by alternative splicing. The Plant journal : for cell and molecular biology 54 10417711
2013 Suppression of PACT-induced type I interferon production by herpes simplex virus 1 Us11 protein. Journal of virology 53 24067967
2001 Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules. The Journal of biological chemistry 52 11717308
1987 Three mutants of herpes simplex virus type 2: one lacking the genes US10, US11 and US12 and two in which Rs has been extended by 6 kb to 0.91 map units with loss of Us sequences between 0.94 and the Us/TRs junction. The Journal of general virology 50 3027237
1991 Herpes simplex virus 1 RNA-binding protein US11 negatively regulates the accumulation of a truncated viral mRNA. Journal of virology 49 1656075
2004 Full resistance of herpes simplex virus type 1-infected primary human cells to alpha interferon requires both the Us11 and gamma(1)34.5 gene products. Journal of virology 48 15331752
1993 The herpes simplex virus type 1 US11 gene product is a phosphorylated protein found to be non-specifically associated with both ribosomal subunits. The Journal of general virology 48 8383175
2011 The PPR-DYW proteins are required for RNA editing of rps14, cox1 and nad5 transcripts in Physcomitrella patens mitochondria. FEBS letters 46 21708151
2002 Inhibitory effects of cytomegalovirus proteins US2 and US11 point to contributions from direct priming and cross-priming in induction of vaccinia virus-specific CD8(+) T cells. Journal of immunology (Baltimore, Md. : 1950) 45 12023332
2011 Nucleolin interacts with US11 protein of herpes simplex virus 1 and is involved in its trafficking. Journal of virology 44 22130536
2002 The MHC class I homolog of human cytomegalovirus is resistant to down-regulation mediated by the unique short region protein (US)2, US3, US6, and US11 gene products. Journal of immunology (Baltimore, Md. : 1950) 43 11907106
2002 The HCMV gene products US2 and US11 target MHC class I molecules for degradation in the cytosol. Current topics in microbiology and immunology 42 12224515
2019 Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome. Leukemia 39 30651631
2006 Ubiquitination of MHC class I heavy chains is essential for dislocation by human cytomegalovirus-encoded US2 but not US11. The Journal of biological chemistry 39 16877758
1994 A mammalian origin of bidirectional DNA replication within the Chinese hamster RPS14 locus. Molecular and cellular biology 39 8065299
2018 Herpes Simplex Virus 1 Inhibits TANK-Binding Kinase 1 through Formation of the Us11-Hsp90 Complex. Journal of virology 38 29743370
2003 Amino acid composition of alpha1/alpha2 domains and cytoplasmic tail of MHC class I molecules determine their susceptibility to human cytomegalovirus US11-mediated down-regulation. European journal of immunology 36 12778489
1980 Linkage in cultured Chinese hamster cells of two genes, emtB and leuS, involved in protein synthesis and isolation of cell lines with mutations in three linked genes. The Journal of cell biology 36 7193212
2019 Disassembly of the TRIM23-TBK1 Complex by the Us11 Protein of Herpes Simplex Virus 1 Impairs Autophagy. Journal of virology 35 31189704
2006 Pervasive survival of expressed mitochondrial rps14 pseudogenes in grasses and their relatives for 80 million years following three functional transfers to the nucleus. BMC evolutionary biology 35 16842621
2005 Identification of cytomegalovirus-specific cytotoxic T lymphocytes in vitro is greatly enhanced by the use of recombinant virus lacking the US2 to US11 region or modified vaccinia virus Ankara expressing individual viral genes. Journal of virology 33 15709006
2006 E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. Proceedings of the National Academy of Sciences of the United States of America 31 16868077
1999 Transcriptional regulation of the human cytomegalovirus US11 early gene. Journal of virology 31 9882286
2017 The thrombopoietin/MPL axis is activated in the Gata1low mouse model of myelofibrosis and is associated with a defective RPS14 signature. Blood cancer journal 30 28622305
2016 A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure. Journal of genetics and genomics = Yi chuan xue bao 30 27216296
2004 Transfer of RPS14 and RPL5 from the mitochondrion to the nucleus in grasses. Gene 30 14693379
2000 Expression of herpes simplex virus ICP47 and human cytomegalovirus US11 prevents recognition of transgene products by CD8(+) cytotoxic T lymphocytes. Journal of virology 30 10775582
2010 Molecular anatomy of subcellular localization of HSV-1 tegument protein US11 in living cells. Virus research 28 20633584
2015 Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11. PloS one 27 26624888
2005 Subtle sequence variation among MHC class I locus products greatly influences sensitivity to HCMV US2- and US11-mediated degradation. International immunology 27 16361314
1996 The rpl5-rps14-cob gene arrangement in Solanum tuberosum: rps14 is a transcribed and unedited pseudogene. Plant molecular biology 27 8806426
1986 DNA replication is required for abundant expression of a plasmid-borne late US11 gene of herpes simplex virus type 1. Nucleic acids research 27 3012478
2005 Binding of herpes simplex virus-1 US11 to specific RNA sequences. Nucleic acids research 25 16246910
2004 US11 of herpes simplex virus type 1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrest. Journal of virology 24 14990717
2008 Protection against heat and staurosporine mediated apoptosis by the HSV-1 US11 protein. Virology 21 18395766
2023 CircZSWIM6 mediates dysregulation of ECM and energy homeostasis in ageing chondrocytes through RPS14 post-translational modification. Clinical and translational medicine 20 36604982
2023 Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea. Cell proliferation 20 36977657
2009 Ribosomal protein RPS-14 modulates let-7 microRNA function in Caenorhabditis elegans. Developmental biology 20 19627982
2005 Human cytomegalovirus-encoded US2 and US11 target unassembled MHC class I heavy chains for degradation. Molecular immunology 20 16098592
2000 The translational apparatus of Tortula ruralis: polysomal retention of transcripts encoding the ribosomal proteins RPS14, RPS16 and RPL23 in desiccated and rehydrated gametophytes. Journal of experimental botany 20 11053454
1997 Herpes simplex virus Us11 protein enhances recovery of protein synthesis and survival in heat shock treated HeLa cells. Cell stress & chaperones 20 9250403
2019 MMP9 inhibition increases erythropoiesis in RPS14-deficient del(5q) MDS models through suppression of TGF-β pathways. Blood advances 19 31540902
1999 Cotranscription of the rpl5-rps14-cob gene cluster in pea mitochondria. Molecular & general genetics : MGG 19 10323235
1994 A herpes simplex virus 1 US11-expressing cell line is resistant to herpes simplex virus infection at a step in viral entry mediated by glycoprotein D. Journal of virology 19 8151754
2021 Integrated analyses of translatome and proteome identify the rules of translation selectivity in RPS14-deficient cells. Haematologica 18 32327500
2009 TRAM1 participates in human cytomegalovirus US2- and US11-mediated dislocation of an endoplasmic reticulum membrane glycoprotein. The Journal of biological chemistry 17 19121997
2009 Low RPS14 expression is common in myelodysplastic syndromes without 5q- aberration and defines a subgroup of patients with prolonged survival. Haematologica 17 19794090
2002 The herpes simplex virus type 1 US11 protein binds the coterminal UL12, UL13, and UL14 RNAs and regulates UL13 expression in vivo. Journal of virology 17 12134014
2022 RPS14 promotes the development and progression of glioma via p53 signaling pathway. Experimental cell research 16 36535509
2019 The US11 Gene of Herpes Simplex Virus 1 Promotes Neuroinvasion and Periocular Replication following Corneal Infection. Journal of virology 16 30760571
2003 Effective suppression of class I major histocompatibility complex expression by the US11 or ICP47 genes can be limited by cell type or interferon-gamma exposure. Human gene therapy 16 14670127
1995 Phosphorylation of herpes simplex virus type 1 Us11 protein is independent of viral genome expression. Electrophoresis 16 7498183
2001 Expression dynamics of human cytomegalovirus immune evasion genes US3, US6, and US11 in the blood of lung transplant recipients. The Journal of infectious diseases 15 11443549
1991 Molecular evolution of the mammalian ribosomal protein gene, RPS14. Molecular biology and evolution 15 1921707
2019 HLA-B locus products resist degradation by the human cytomegalovirus immunoevasin US11. PLoS pathogens 14 31527904
2011 The role of haploinsufficiency of RPS14 and p53 activation in the molecular pathogenesis of the 5q- syndrome. Pediatric reports 14 22053272
2021 Downregulation of RPS14 inhibits the proliferation and metastasis of estrogen receptor-positive breast cancer cells. Anti-cancer drugs 13 34261921
2013 Low RPS14 expression in MDS without 5q - aberration confers higher apoptosis rate of nucleated erythrocytes and predicts prolonged survival and possible response to lenalidomide in lower risk non-5q- patients. European journal of haematology 13 23506134
2005 Functional dissection of HCMV US11 in mediating the degradation of MHC class I molecules. Biochemical and biophysical research communications 13 15823579
2004 The rpl5- rps14 mitochondrial region: a hot spot for DNA rearrangements in Solanum spp. somatic hybrids. Current genetics 13 15034752
1995 A densely methylated DNA island is associated with a chromosomal replication origin in the human RPS14 locus. Somatic cell and molecular genetics 13 8600566
2003 Interactions of yeast ribosomal protein rpS14 with RNA. Journal of molecular biology 12 14568531
2001 The US11 gene product of herpes simplex virus has intercellular trafficking activity. Biochemical and biophysical research communications 12 11676485
1985 Synthesis and incorporation of human ribosomal protein S14 into functional ribosomes in human-Chinese hamster cell hybrids containing human chromosome 5: human RPS14 gene is the structural gene for ribosomal protein S14. Somatic cell and molecular genetics 12 3865384

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