Affinage

RPS13

Small ribosomal subunit protein uS15 · UniProt P62277

Length
151 aa
Mass
17.2 kDa
Annotated
2026-06-10
100 papers in source corpus 19 papers cited in narrative 17 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPS13 (uS15) is a conserved small ribosomal subunit protein of the 40S/30S head whose direct RNA contacts and inter-subunit position underpin core steps of translation (PMID:15876367, PMID:8718688). It binds the 3' major domain of 16S/18S rRNA (contacting nucleotides ~1308–1338 and the 950/1230 helix) through its C-terminal RNA-binding domain, while the eukaryotic protein also binds 5.8S rRNA, establishing it as a multivalent rRNA-binding protein within the subunit head (PMID:8718688, PMID:2437527, PMID:7251593, PMID:3903659). During 30S assembly it joins via the S7 branch and makes cooperative contacts with neighboring head proteins, including a defined cross-link to S19 mediated by its N-terminal region (PMID:15525707, PMID:2459390, PMID:3279034, PMID:3291949, PMID:3903659). Functionally, RPS13 is required for subunit association, translation initiation, and translocation: its bridge contacts and tRNA-contacting C-terminal extension transmit signals between the tRNA-binding site and the subunit head, and truncation of the C-terminus impairs translational step time and fidelity (PMID:15876367, PMID:8193163, PMID:8360163). Beyond the ribosome, free RPS13 protein binds its own pre-mRNA and inhibits splicing of intron 1, constituting a feedback autoregulatory loop controlling its expression (PMID:17881366, PMID:17380891). In Drosophila the gene behaves as a classical Minute locus required for normal growth and for germline stem cell self-renewal, acting upstream of Rho1-mediated adhesion signaling (PMID:8725235, PMID:32896929). In gastric cancer cells, elevated RPS13 suppresses drug-induced apoptosis by raising the Bcl-2/Bax ratio and drives G1-to-S progression by down-regulating p27(Kip1) and reducing CDK2 activity (PMID:15149863, PMID:19912438).

Mechanistic history

Synthesis pass · year-by-year structured walk · 14 steps
  1. 1981 Medium

    Established that the eukaryotic protein has intrinsic rRNA-binding specificity by showing direct, stoichiometric binding to 5.8S rRNA, distinguishing it from purely bacterial-defined contacts.

    Evidence Nitrocellulose filter binding of purified rat liver rpS13 to 5.8S rRNA with stoichiometry analysis

    PMID:7251593

    Open questions at the time
    • Binding site on 5.8S rRNA not mapped at nucleotide resolution
    • Functional consequence within assembled 60S/80S not addressed
  2. 1985 Medium

    Resolved the domain architecture of the protein, showing RNA binding and inter-protein contact map to separable regions.

    Evidence Proteolytic dissection of E. coli S13 with filter-binding and S19 competition assays

    PMID:3903659

    Open questions at the time
    • Residue-level boundaries of the two functions not defined
    • Bacterial ortholog; eukaryotic domain map inferred
  3. 1987 Medium

    Mapped direct protein–rRNA cross-link sites, anchoring S13 to specific 16S rRNA positions.

    Evidence Photo-cross-linking with methyl p-azidophenyl acetimidate and nuclease mapping in 30S subunits

    PMID:2437527

    Open questions at the time
    • Anomalous 189–191 cross-link unexplained
    • Single cross-linking chemistry
  4. 1988 High

    Defined the head-region neighbor of S13 by identifying its protein partner and the precise cross-link residues, and placed it among 3' major domain binders.

    Evidence Diepoxybutane cross-linking with peptide sequencing/FAB-MS (S13–S19), plus assembly probing of the 3' major domain

    PMID:2459390 PMID:3279034 PMID:3291949

    Open questions at the time
    • Functional significance of the S13–S19 contact not tested
    • Eukaryotic equivalence of partner contact not shown
  5. 1994 Medium

    Linked the C-terminal RNA-binding domain to translational performance by phenotyping a defined truncation allele.

    Evidence rpsM C-terminal truncation in E. coli; sucrose gradients and suppressor activity assays

    PMID:8193163

    Open questions at the time
    • Molecular step defect not isolated in vitro
    • Effect on initiation versus elongation not separated
  6. 1996 High

    Localized the protein within the 16S rRNA tertiary fold and within the subunit by tethered cleavage and immune EM, and revealed that the gene host encodes intronic U14 snoRNAs.

    Evidence Fe(II)-tethered hydroxyl radical probing from Cys84; immune EM of reconstituted 30S; genomic sequencing of the human S13 locus

    PMID:8360163 PMID:8718688 PMID:8920921

    Open questions at the time
    • Whether U14 processing depends on RPS13 transcription/splicing not tested
    • Interface position confirmed structurally but functional bridging assayed later
  7. 1996 Medium

    Established the gene as a haploinsufficient growth determinant, the classical Minute phenotype, by mutagenesis and genetic rescue.

    Evidence P-element insertion in Drosophila RpS13 with Northern quantification and rescue by excision

    PMID:8725235

    Open questions at the time
    • Mechanism linking reduced ribosomal protein to bristle/growth phenotype not dissected
    • Drosophila ortholog
  8. 2004 Medium

    Refined the 30S assembly pathway, reassigning S13 dependency from S20 to S7 and showing cooperative head-protein interactions.

    Evidence Chemical footprinting and single-protein addition/omission assembly studies

    PMID:15525707

    Open questions at the time
    • Kinetics of assembly not measured
    • Eukaryotic assembly order not addressed
  9. 2004 Medium

    Connected RPS13 dosage to cancer cell survival, showing overexpression confers multidrug resistance via apoptosis suppression independent of translation rate.

    Evidence RPS13 overexpression in SGC7901 gastric cancer cells; apoptosis assays, Bcl-2/Bax Western, drug accumulation and [3H]leucine incorporation

    PMID:15149863

    Open questions at the time
    • Direct molecular link between RPS13 and Bcl-2 regulation unknown
    • Single cell line
  10. 2005 High

    Defined the core ribosomal mechanism of the protein, demonstrating it transmits signals between the tRNA site and subunit head during translocation through distinct bridge and tRNA-contact elements.

    Evidence rpsM-deficient E. coli with in vitro association/initiation/translocation assays and targeted mutagenesis

    PMID:15876367

    Open questions at the time
    • Real-time conformational coupling not visualized
    • Eukaryotic translocation role inferred from bacterial ortholog
  11. 2007 High

    Revealed a non-ribosomal autoregulatory function, showing free RPS13 protein binds its own pre-mRNA and inhibits intron 1 splicing.

    Evidence In vitro splicing inhibition, RNase protection mapping, and minigene assays in HEK293 with rpS10/rpS16 specificity controls

    PMID:17380891 PMID:17881366

    Open questions at the time
    • Cellular threshold of free RPS13 triggering autoregulation not quantified
    • Spliceosomal factors involved not identified
  12. 2011 Medium

    Extended the oncogenic role to cell cycle control, showing RPS13 drives G1/S transition via p27(Kip1) down-regulation and reduced CDK2 activity.

    Evidence Reciprocal overexpression/knockdown in gastric cancer cells; flow cytometry, Western blots, CDK2 kinase assay, in vivo tumor formation

    PMID:19912438

    Open questions at the time
    • Mechanism of p27 regulation by RPS13 unresolved
    • Whether effect is ribosome-dependent not addressed
  13. 2013 Low

    Probed how rRNA conformation gates RPS13 binding, showing Mg2+-induced 18S rearrangements lower its affinity.

    Evidence In vitro binding of recombinant human rpS13 to 18S central domain with hydroxyl radical probing at varying Mg2+

    PMID:23705505

    Open questions at the time
    • Single biochemical method without independent confirmation
    • Physiological relevance during assembly not established
  14. 2020 Medium

    Placed RPS13 in a developmental signaling context, showing it controls germline stem cell self-renewal upstream of Rho1-mediated adhesion.

    Evidence Tissue-specific RNAi in Drosophila testes/S2 cells with stem cell markers, apoptosis assays, qRT-PCR, and Rho1 epistasis

    PMID:32896929

    Open questions at the time
    • Whether the role is extraribosomal or via translation not separated
    • Direct link to Rho1/cadherin pathway not biochemically defined

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved whether the cancer-associated apoptosis and cell-cycle phenotypes and the Drosophila adhesion role reflect extraribosomal moonlighting functions of RPS13 or downstream consequences of altered ribosome biogenesis/translation.
  • No direct molecular targets identified for the apoptosis/cell-cycle effects
  • Extraribosomal versus ribosomal contributions not separated
  • No human structural model of RPS13 within 40S in this corpus

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 5 GO:0005198 structural molecule activity 2 GO:0045182 translation regulator activity 2
Localization
GO:0005840 ribosome 3
Pathway
R-HSA-8953854 Metabolism of RNA 1
Partners
RPS19
Complex memberships
40S/30S small ribosomal subunit

Evidence

Reading pass · 17 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2007 Human RPS13 specifically binds to a fragment of its own pre-mRNA encompassing exons 1 and 2, intron 1, and part of intron 2, and inhibits splicing of intron 1 in vitro, providing ribonuclease protection at sequences near the 5' and 3' splice sites; this constitutes a feedback autoregulatory mechanism controlling RPS13 expression at the splicing step. In vitro splicing inhibition assay with recombinant rpS13; RNase protection mapping of protein-binding sites on pre-mRNA; transfection of HEK 293 cells with minigene containing intron 1 Nucleic acids research High 17380891 17881366
2004 Overexpression of human RPS13 in gastric cancer cells (SGC7901) promotes multidrug resistance by suppressing drug-induced apoptosis and significantly increasing Bcl-2 expression and Bcl-2/Bax ratio, without altering drug accumulation or protein synthesis rates. Genetic overexpression of RPS13 in gastric cancer cells; cell viability and apoptosis assays; Western blot for Bcl-2/Bax; [3H]leucine incorporation; intracellular drug accumulation measurement Experimental cell research Medium 15149863
2011 RPS13 promotes gastric cancer cell growth and G1-to-S phase transition by down-regulating p27(Kip1) expression and reducing CDK2 kinase activity, without altering cyclin D, cyclin E, CDK2, CDK4, or p16(INK4A) levels. RPS13 overexpression and RNAi knockdown in gastric cancer cells; cell cycle analysis by flow cytometry; Western blot for cell cycle regulators; CDK2 kinase activity assay; in vivo tumor formation assay Journal of cellular and molecular medicine Medium 19912438
2005 E. coli ribosomal protein S13 (bacterial ortholog of RPS13/uS15) is required for ribosome subunit association, translation initiation, and translocation; targeted mutagenesis of S13 bridge contact elements and tRNA contact elements (C-terminal extension) each individually impair translational fidelity and efficiency, indicating S13 provides signal transduction between the tRNA-binding site and the small subunit head during translocation. rpsM(S13)-deficient E. coli strain; in vitro subunit association, initiation, and translocation assays; targeted mutagenesis of bridge and tRNA contact residues Journal of molecular biology High 15876367
2004 In the 30S ribosomal subunit assembly map, S13 (bacterial ortholog) requires prior association of S7 (not S20 as previously mapped) for binding to the 16S rRNA ribonucleoprotein particle, placing S13 in the S7 assembly branch consistent with its head location; S13 also makes cooperative interactions with other S7-branch proteins. Base-specific chemical footprinting; primer extension analysis; single protein addition and omission studies RNA (New York, N.Y.) Medium 15525707
1988 E. coli ribosomal protein S13 (bacterial ortholog) is cross-linked to proteins S19 in the 30S subunit, with the cross-link site identified at Cys84 of S13 and His68 of S19 by diepoxybutane cross-linking followed by peptide sequencing, FAB-MS, and amino acid analysis. Bifunctional cross-linker diepoxybutane treatment of 30S subunits; HPLC purification of cross-linked S13–S19 complex; enzymatic fragmentation; sequence analysis; FAB-MS The Journal of biological chemistry High 3279034 3291949
1985 E. coli ribosomal protein S13 has two separable functional domains: a C-terminal fragment (residues 84–117) retains 16S rRNA-binding activity at multiple sites, while the N-terminal region is important for association with protein S19, as demonstrated by proteolytic cleavage and filter-binding assays. Proteolytic cleavage of S13 into two polypeptides; nitrocellulose filter-binding assay for RNA binding; S19 competition binding assay Nucleic acids research Medium 3903659
1996 Directed hydroxyl radical probing from Fe(II) tethered to Cys84 of E. coli S13 (bacterial ortholog) in reconstituted 30S subunits localizes S13 adjacent to two regions of 16S rRNA: nucleotides 1308–1333 in the 3' major domain and the 950/1230 helix. In vitro reconstitution of 30S subunits with Fe(II)-EDTA derivatized S13; hydroxyl radical cleavage mapping of 16S rRNA RNA (New York, N.Y.) High 8718688
1987 E. coli ribosomal protein S13 (bacterial ortholog) is cross-linked to 16S rRNA at oligonucleotide positions 1337–1338 and anomalously at positions 189–191 in the 30S subunit, using methyl p-azidophenyl acetimidate photo-cross-linking. Photo-cross-linking with methyl p-azidophenyl acetimidate; partial nuclease digestion; isolation of RNA–protein complexes; RNA and protein analysis Nucleic acids research Medium 2437527
1988 Ribosomal proteins S2, S3, S10, S13, and S14 bind to the 3' major domain of 16S rRNA; S13 and S14 each protect distinct nucleotides adjacent to regions previously protected by S19, as revealed by chemical and enzymatic probing during assembly of the 30S subunit. Chemical and enzymatic probing of 16S rRNA during stepwise assembly; monospecific and cooperative protection pattern analysis Journal of molecular biology Medium 2459390
1981 Rat liver ribosomal protein S13 specifically binds to 5.8S rRNA with a single binding site per RNA molecule and an apparent association constant in the range of 0.2–18 × 10^5 M^-1 (measured at 4°C and 22°C), as determined by nitrocellulose membrane filtration. Nitrocellulose membrane filter binding assay with purified rat liver rpS13 and 5.8S rRNA; saturation binding and stoichiometry analysis The Journal of biological chemistry Medium 7251593
1994 A C-terminal truncation of E. coli S13 (rpsM mutation removing 19 C-terminal amino acids, including the RNA-binding C-terminal domain) causes decreased translational step time, reduced growth rate, and strong antisuppression of amber and opal suppressors, consistent with impaired ribosomal function; the truncated small subunit shows reduced sedimentation but forms apparently normal 70S ribosomes. Cloning and sequencing of rpsM mutation; sucrose gradient ultracentrifugation; suppressor activity assays in vivo Biochimica et biophysica acta Medium 8193163
2020 Drosophila RpS13 is required for germline stem cell self-renewal and differentiation in the testis niche; knockdown of RpS13 affects cell proliferation and apoptosis and modulates expression of ribosome subunits, Rho1, DE-cad (E-cadherin), and Armadillo (β-catenin); Rho1 overexpression phenocopies RpS13 loss, placing RpS13 upstream of Rho1-mediated cell adhesion signaling. Tissue-specific RNAi knockdown in Drosophila testes and S2 cells; immunofluorescence for stem cell markers; TUNEL/flow cytometry for apoptosis; qRT-PCR; genetic epistasis with Rho1 Cell proliferation Medium 32896929
1996 Loss-of-function P-element insertion in Drosophila RpS13 (encoding the Drosophila ortholog of ribosomal protein S13) causes the Minute phenotype (short thin bristles, slow development) and reduces RPS13 transcript to ~50%; the phenotype is rescued by P-element remobilization, establishing this as a classical Minute ribosomal protein gene. P-element mutagenesis; sequencing of interrupted gene; Northern blot quantification of transcript; genetic rescue by P-element excision Genetics Medium 8725235
1993 Protein S13 (DNP-labeled) in reconstituted E. coli 30S subunits is localized by immune electron microscopy to the subunit head above the platform and on the surface facing the large subunit, confirming its position at the subunit interface. Dinitrophenylation of S13; total reconstitution of 30S subunits with DNP-S13; immune electron microscopy with anti-DNP antibodies The Journal of biological chemistry Medium 8360163
2013 Mg2+ ions (at concentrations 0.5–20 mM) reduce the affinity of human rpS13 for the central domain fragment of 18S rRNA by inducing structural rearrangements in helices H20 and H22 of the 18S rRNA central domain that mimic the conformation found in assembled 40S subunits, as detected by hydroxyl radical probing. In vitro binding of recombinant human rpS13 to 18S rRNA central domain RNA; hydroxyl radical probing of RNA structure at varying Mg2+ concentrations Molekuliarnaia biologiia Low 23705505
1996 U14 small nucleolar RNAs (snoRNAs) are encoded within introns 3 and 5 of the human RPS13 gene, identified by PCR cloning and sequencing of the intron-containing genomic locus; the gene structure comprises 6 exons and 5 introns spanning 3.3 kb. PCR cloning and sequencing of intron-containing human S13 genomic gene; sequence comparison with Xenopus U14 snoRNA genes Biochemical and biophysical research communications Medium 8920921

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1996 (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta. Journal of medicinal chemistry 277 8709095
2004 Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis. Experimental cell research 97 15149863
2005 Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca: evidence for an iterative bacterial type I polyketide synthase and for module skipping in nonribosomal peptide biosynthesis. Chembiochem : a European journal of chemical biology 89 15651040
1988 Positions of S2, S13, S16, S17, S19 and S21 in the 30 S ribosomal subunit of Escherichia coli. Journal of molecular biology 88 3288761
1976 The isolation of eukaryotic ribosomal proteins. The purification and characterization of the 40 S ribosomal subunit proteins S2, S3, S4, S5, S6, S7, S8, S9, S13, S23/S24, S27, and S28. The Journal of biological chemistry 72 947902
1989 The v-sea oncogene of avian erythroblastosis retrovirus S13: another member of the protein-tyrosine kinase gene family. Proceedings of the National Academy of Sciences of the United States of America 69 2546151
2015 Are cyclic lipopeptides produced by Bacillus amyloliquefaciens S13-3 responsible for the plant defence response in strawberry against Colletotrichum gloeosporioides? Letters in applied microbiology 66 25511625
1986 Control of erythroid differentiation: asynchronous expression of the anion transporter and the peripheral components of the membrane skeleton in AEV- and S13-transformed cells. The Journal of cell biology 57 2946700
2007 Human ribosomal protein S13 regulates expression of its own gene at the splicing step by a feedback mechanism. Nucleic acids research 56 17881366
1989 Gene encoding the alpha core subunit of Bacillus subtilis RNA polymerase is cotranscribed with the genes for initiation factor 1 and ribosomal proteins B, S13, S11, and L17. Journal of bacteriology 54 2496109
1988 Probing the assembly of the 3' major domain of 16 S rRNA. Interactions involving ribosomal proteins S2, S3, S10, S13 and S14. Journal of molecular biology 53 2459390
1987 RNA-protein cross-linking in Escherichia coli 30S ribosomal subunits; determination of sites on 16S RNA that are cross-linked to proteins S3, S4, S5, S7, S8, S9, S11, S13, S19 and S21 by treatment with methyl p-azidophenyl acetimidate. Nucleic acids research 53 2437527
2011 Human ribosomal protein S13 promotes gastric cancer growth through down-regulating p27(Kip1). Journal of cellular and molecular medicine 52 19912438
2003 Use of RNA interference and complementation to study the function of the Drosophila and human 26S proteasome subunit S13. Molecular and cellular biology 52 12861018
1985 UV-induced mutagenesis of phage S13 can occur in the absence of the RecA and UmuC proteins of Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America 52 2995974
2005 Multiple effects of S13 in modulating the strength of intersubunit interactions in the ribosome during translation. Journal of molecular biology 51 15876367
1994 The S11 and S13 self incompatibility alleles in Solanum chacoense Bitt. are remarkably similar. Plant molecular biology 45 8155878
1990 Species-specific RNA editing patterns in the mitochondrial rps13 transcripts of Oenothera and Daucus. Molecular & general genetics : MGG 45 2266944
1985 The putative transforming protein of S13 avian erythroblastosis virus is a transmembrane glycoprotein with an associated protein kinase activity. Proceedings of the National Academy of Sciences of the United States of America 45 2999798
2018 Purification and biochemical characterization of two keratinases from Bacillus amyloliquefaciens S13 isolated from marine brown alga Zonaria tournefortii with potential keratin-biodegradation and hide-unhairing activities. International journal of biological macromolecules 44 30389529
1987 The mitochondrial S13 ribosomal protein gene is silent in wheat embryos and seedlings. Nucleic acids research 41 2827122
1985 S13, a rapidly oncogenic replication-defective avian retrovirus. Virology 41 2990096
2003 Membrane proteome of Acinetobacter radioresistens S13 during aromatic exposure. Proteomics 39 12833532
2007 Degradation of aromatic compounds by Acinetobacter radioresistens S13: growth characteristics on single substrates and mixtures. Archives of microbiology 36 17483933
1993 Over-expression of the S13 ribosomal protein in actively growing cells. International journal of cancer 36 8370626
1985 Avian retrovirus S13: properties of the genome and of the transformation-specific protein. Virology 36 2990097
2002 Cloning and characterization of two catechol 1,2-dioxygenase genes from Acinetobacter radioresistens S13. Research in microbiology 30 11900265
2004 Assembly of the 30S ribosomal subunit: positioning ribosomal protein S13 in the S7 assembly branch. RNA (New York, N.Y.) 29 15525707
2009 Catalytic properties of catechol 1,2-dioxygenase from Acinetobacter radioresistens S13 immobilized on nanosponges. Dalton transactions (Cambridge, England : 2003) 28 19672496
1996 A novel Drosophila Minute locus encodes ribosomal protein S13. Genetics 27 8725235
1996 Directed hydroxyl radical probing of the rRNA neighborhood of ribosomal protein S13 using tethered Fe(II). RNA (New York, N.Y.) 24 8718688
1967 Bacteriophage S13: a 7th gene. Science (New York, N.Y.) 24 6022230
2003 The oxygenase component of phenol hydroxylase from Acinetobacter radioresistens S13. European journal of biochemistry 23 12752444
1985 Nucleotide sequence and genome organization of bacteriophage S13 DNA. Gene 23 3007293
1998 Editing and translation of ribosomal protein S13 transcripts: unedited translation products are not detectable in maize mitochondria. Current genetics 22 9745026
1988 Identification of a cross-link in the Escherichia coli ribosomal protein pair S13-S19 at the amino acid level. The Journal of biological chemistry 22 3279034
1981 Characterization of the binding of rat liver ribosomal proteins L6, L8, L19, S9, and S13 to 5.8 S ribosomal ribonucleic acid. The Journal of biological chemistry 22 7251593
1977 Primary structure of protein S13 from the small subunit of escherichia coli ribosomes. Hoppe-Seyler's Zeitschrift fur physiologische Chemie 22 330375
2020 Fabrication of a Robust PEM Water Electrolyzer Based on Non-Noble Metal Cathode Catalyst: [Mo3 S13 ]2- Clusters Anchored to N-Doped Carbon Nanotubes. Small (Weinheim an der Bergstrasse, Germany) 20 32803861
2020 RpS13 controls the homeostasis of germline stem cell niche through Rho1-mediated signals in the Drosophila testis. Cell proliferation 20 32896929
2016 Comprehensive genomic and phenotypic metal resistance profile of Pseudomonas putida strain S13.1.2 isolated from a vineyard soil. AMB Express 20 27730570
1993 cDNA nucleotide sequence and expression of a maize cytoplasmic ribosomal protein S13 gene. Plant molecular biology 19 8448368
1972 Characterization of bacteriophage S13 suN15 single-strand and replicative-form deoxyribonucleic acid. Journal of virology 19 4557206
1967 Direction of translation in bacteriophage S13. Science (New York, N.Y.) 19 6053883
2017 Adsorption of Staphylococcus viruses S13' and S24-1 on Staphylococcus aureus strains with different glycosidic linkage patterns of wall teichoic acids. The Journal of general virology 18 28730979
2016 Validation of RPS13 as a reference gene for absolute quantification of SIV RNA in tissue of rhesus macaques. Journal of virological methods 18 27510462
1990 The primary structure of rat ribosomal protein S13. Biochemical and biophysical research communications 18 2403345
1986 Multiple crosslinks of proteins S7, S9, S13 to domains 3 and 4 of 16S RNA in the 30S particle. Nucleic acids research 18 2423965
1979 Localization of Escherichia coli RNA polymerase binding sites on bacteriophage S13 and 0X174 DNAs by electron microscopy. Journal of virology 18 372559
1969 Cytosine to thymine transitions from decay of cytosine-5-3H in bacteriophage S13. Science (New York, N.Y.) 18 5360583
1988 Cross-linked amino acids in the protein pair S13-S19 and sequence analysis of protein S13 of Bacillus stearothermophilus ribosomes. Biochemistry 17 3291949
1985 Evidence that E. coli ribosomal protein S13 has two separable functional domains involved in 16S RNA recognition and protein S19 binding. Nucleic acids research 17 3903659
2021 Tightly linked Rps12 and Rps13 genes provide broad-spectrum Phytophthora resistance in soybean. Scientific reports 16 34413429
2019 One-Step Reconstruction with a Novel Suspended, Modular, and 3D-Printed Total Sacral Implant Resection of Sacral Giant Cell Tumor with Preservation of Bilateral S1-3 Nerve Roots via a Posterior-Only Approach. Orthopaedic surgery 16 31854115
2006 RNA editing has been lost in the mitochondrial cox3 and rps13 mRNAs in Asparagales. Biochimie 16 17092626
1996 U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene. Biochemical and biophysical research communications 16 8920921
1980 Purification of Drosophila ribosomal proteins. Isolation of proteins S8, S13, S14, S16, S19, S20/L24, S22/L26, S24, S25/S27, S26, S29, L4, L10/L11, L12, L13, L16, L18, L19, L27, 1, 7/8, 9, and 11. Biochemistry 16 6773542
1976 Nucleotide clusters in deoxyribonucleic acids. Comparison of the sequences of the large pyrimidine oligonucleotides of bacteriophages S13 and phiX174 deoxyribonucleic acids. Biochemistry 16 174716
2014 In silico analysis of AHJD-like viruses, Staphylococcus aureus phages S24-1 and S13', and study of phage S24-1 adsorption. MicrobiologyOpen 15 24591378
2012 Whole-genome synthesis and characterization of viable S13-like bacteriophages. PloS one 15 22815936
1992 The murine MHC encodes a mammalian homolog of bacterial ribosomal protein S13. Mammalian genome : official journal of the International Mammalian Genome Society 15 1543907
2008 Molecular adaptation and expression evolution following duplication of genes for organellar ribosomal protein S13 in rosids. BMC evolutionary biology 14 18221556
1971 Superinfection in bacteriophage S13 and determination of the number of bacteriophage particles which can function in an infected cell. Journal of virology 14 4937062
2013 Genome Sequence of Serratia plymuthica Strain S13, an Endophyte with Germination- and Plant-Growth-Promoting Activity from the Flower of Styrian Oil Pumpkin. Genome announcements 11 23929484
2010 High isoelectric point sub-proteome analysis of Acinetobacter radioresistens S13 reveals envelope stress responses induced by aromatic compounds. Molecular bioSystems 11 20953507
1993 Proliferation of spleen colony forming units (CFU-S8, CFU-S13) and cells with marrow repopulating ability. Stem cells (Dayton, Ohio) 11 8318908
1969 Synthesis of replicative form deoxyribonucleic acid and messenger ribonucleic acid by gene IV mutants of bacteriophage S13. Journal of virology 11 4898585
2003 Phenol hydroxylase from Acinetobacter radioresistens S13. Isolation and characterization of the regulatory component. European journal of biochemistry 10 12653998
1989 Epitope characterization by modifications of antigens and by mapping on resin-bound peptides. Discriminating epitopes near the C-terminus and N-terminus of Escherichia coli ribosomal protein S13. Journal of immunological methods 10 2466901
2019 Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13. Biochemical and biophysical research communications 9 31677786
1996 Overproduction of mycobacterial ribosomal protein S13 induces catalase/peroxidase activity and hypersensitivity to isoniazid in Mycobacterium smegmatis. Gene 9 8621083
1978 Localization of Escherichia coli RNA polymerase binding sites on bacteriophage S13 and phiX174 DNA: alignment with restriction enzyme maps. Journal of virology 9 359830
1993 Placement of dinitrophenyl-modified ribosomal proteins in totally reconstituted Escherichia coli 30 S subunits. Localization of proteins S6, S13, S16, and S18 by immune electron microscopy. The Journal of biological chemistry 8 8360163
1994 Role of oligomerization of the S13 Env-Sea oncoprotein in cell transformation. Journal of virology 7 7509003
2004 Human ribosomal protein S13: cloning, expression, refolding, and structural stability. Biochimica et biophysica acta 6 15680243
1994 Antisuppression by a mutation in rpsM(S13) giving a shortened ribosomal protein S13. Biochimica et biophysica acta 6 8193163
1989 Epitopes of Escherichia coli ribosomal protein S13. Journal of protein chemistry 6 2483051
1987 Mapping the B and D gene promoters of bacteriophage S13 by footprinting and exonuclease III analysis. Journal of virology 6 2824808
2024 MerlinS13 phosphorylation regulates meningioma Wnt signaling and magnetic resonance imaging features. Nature communications 5 39251601
2021 Excited state hydrogen atom transfer pathways in 2,7-diazaindole - S1-3 (S = H2O and NH3) clusters. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 5 34560582
1997 The wheat mitochondrial rps13 gene: RNA editing and co-transcription with the atp6 gene. Current genetics 5 9211793
1977 The nucleotide sequence of two restriction fragments located in the gene AB region of bacteriophage S13. Nucleic acids research 5 909772
1998 Identification of the in vivo promoters of bacteriophages S13 and phi X174 and measurement of their relative activities. Biochemistry and cell biology = Biochimie et biologie cellulaire 4 10099783
1994 Mapping the initiation sites of in vitro transcripts of bacteriophage S13. Biochimica et biophysica acta 4 8049259
1994 Mapping of RNA polymerase binding sites in the H/A gene region of bacteriophage S13 by footprinting and exonuclease III analysis. Biochimica et biophysica acta 4 8049260
1987 Localization of Escherichia coli RNA polymerase-binding sites on bacteriophage S13 replicative form I DNA by protection of restriction enzyme cleavage sites. Journal of virology 4 3035227
2012 An EPR, thermostability and pH-dependence study of wild-type and mutant forms of catechol 1,2-dioxygenase from Acinetobacter radioresistens S13. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 3 23224984
2007 [Human ribosomal protein S13 inhibits splicing of the own pre-mRNA]. Molekuliarnaia biologiia 3 17380891
1988 Lethal modifications of DNA via the transmutation of 32P and 33P incorporated in the genome of the S13 bacteriophage. Radiation and environmental biophysics 3 3067254
2025 Screening of Fecal Bacteroides Strains and Discovery of Bacteroides eggerthii S13-F8 with Protective Effects Against Chemotherapy-Induced Diarrhea. Probiotics and antimicrobial proteins 2 40423879
2013 [Mg2+ ions affect the structure of the central domain of the 18S rRNA in the vicinity of the ribosomal protein S13 binding site]. Molekuliarnaia biologiia 2 23705505
2011 cDNA, genomic sequence cloning and overexpression of the ribosomal protein S13 gene in the giant panda (Ailuropoda melanoleuca). Genetics and molecular research : GMR 2 21268784
1993 Incorporation of dinitrophenyl derivatives of proteins S6, S13, S16, and S18 into the 30 S subunit of Escherichia coli ribosomes by total reconstitution. The Journal of biological chemistry 2 7689558
1976 Nucleotide clusters in deoxyribonucleic acids. XIII. Sequence analysis of the longer unique pyrimidine oligonucleotides of bacteriophage S13 DNA by a method using unlabeled atarting oligonucleotides. Biochimica et biophysica acta 2 779845
2023 MerlinS13 phosphorylation controls meningioma Wnt signaling and magnetic resonance imaging features. Research square 1 36993679
2021 Distribution of amoebal endosymbiotic environmental chlamydia Neochlamydia S13 via amoebal cytokinesis. Microbiology and immunology 1 33368645
2007 [Prokaryotic expression and purification of RPS13 and preparation of polyclonal antibody against RPS13]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 1 17428396
2001 RNA editing of the ribosomal protein S13 transcripts in magnolia and sunflower mitochondria. Plant & cell physiology 1 11479385
1999 Unique features of Chinese hamster S13 gene relative to its human and Xenopus analogs. DNA and cell biology 1 10390155
1992 Immunologic characterization of jird lymphocyte responsiveness to Brugia pahangi ribosomal protein S13. Experimental parasitology 1 1385208

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