Affinage

RPN1

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 · UniProt P04843

Length
607 aa
Mass
68.6 kDa
Annotated
2026-06-10
55 papers in source corpus 16 papers cited in narrative 16 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPN1 (Rpn1/ribophorin I) is a multifunctional scaffold that operates in two distinct cellular machines: the 19S regulatory particle of the 26S proteasome and the endoplasmic reticulum oligosaccharyltransferase (OST) complex (PMID:12198498, PMID:41935956). As the largest subunit of the proteasome base, its toroid/LRR-like domain serves as a major ubiquitin-receptor and docking hub, recognizing K48-linked polyubiquitin and the UBL domains of substrate shuttle factors through at least two functional sites—T1, which engages ubiquitin and UBLs and was resolved bound to mono- and K48-diubiquitin, and the adjacent T2, which docks the deubiquitinase Ubp6 to support ubiquitin chain disassembly (PMID:26912900, PMID:28330605). Distinct surfaces on Rpn1 discriminate among shuttle proteins: Rad23 and Dsk2 dock at separate receptor sites, the conserved residue D517 is specifically required for Ddi1 docking and degradation of Ddi1-dependent substrates, and the human ortholog binds the FAT10-pathway shuttle NUB1L (PMID:22318722, PMID:21627799, PMID:22434192), with additional N-terminal ubiquitin/UBL-binding capacity establishing Rpn1 as a multivalent recruitment platform (PMID:34364874, PMID:33617881). Proteasome assembly is regulated by phosphorylation of Ser361 by PIM1/2/3 kinases, which promotes formation of the Rpn1–Rpt2 base precursor and is reversed by the proteasome phosphatase UBLCP1, whose UBL domain binds the Rpn1 LRR-like domain (PMID:31843888, PMID:23667555). In its second role, RPN1 is an essential subunit of the OST-A complex that carries out co-translational N-glycosylation; its C-terminal four-helix bundle mediates ribosome interaction, and a homozygous nonsense variant that truncates this region destabilizes STT3A, RPN2 and DDOST and causes a congenital disorder of glycosylation (PMID:41935956). Through OST-dependent glycosylation RPN1 supports spermatogenesis and meiotic progression and stabilizes glycoprotein substrates including PD-L1 (PMID:40083683, PMID:39705151).

Mechanistic history

Synthesis pass · year-by-year structured walk · 10 steps
  1. 2000 Medium

    Established that Rpn1 is a bona fide structural component of the 19S regulatory particle of the 26S proteasome, anchoring all subsequent functional study to a defined assembly.

    Evidence Functional complementation of the temperature-sensitive yeast nas1 mutant by T. cruzi RPN1

    PMID:11071286

    Open questions at the time
    • Single complementation method; no direct biochemical role assigned
    • Does not address ubiquitin-recognition or OST functions
  2. 2002 High

    Identified Rpn1 as the proteasome subcomponent that receives ubiquitylated cargo, answering how shuttle factors deliver substrates to the base.

    Evidence Direct binding and competition assays showing Rad23/Dsk2 UBL docking on the Rpn1 LRR-like domain; structural modeling of an Rpn1/Rpn2 toroid antechamber

    PMID:12198498 PMID:12270919

    Open questions at the time
    • Toroid antechamber model was computational only
    • Atomic basis of UBL recognition not yet defined
  3. 2011 High

    Defined shuttle-specific docking determinants, showing different UBL carriers use distinct Rpn1 surfaces rather than a single generic receptor.

    Evidence Site-directed mutagenesis (D517A), genetic suppressor screen, and in vivo degradation of the Ddi1-dependent substrate Ufo1

    PMID:21627799

    Open questions at the time
    • Single lab; structural footprint of Ddi1 docking not resolved
    • Whether D517 contributes to other shuttle interactions unclear
  4. 2012 Medium

    Resolved the multivalent docking architecture of Rpn1 and extended its receptor role to the FAT10 pathway.

    Evidence Kinetic binding/affinity measurements distinguishing Rad23, Dsk2 and Ubp6 sites; Co-IP and yeast complementation linking hRpn1 to NUB1L-mediated FAT10 degradation

    PMID:22318722 PMID:22434192

    Open questions at the time
    • NUB1L interaction shown without reciprocal structural mapping
    • Hierarchy among competing factors in vivo not established
  5. 2016 High

    Provided the atomic basis for Rpn1 as a ubiquitin receptor, defining the T1 and T2 functional sites and a K48-chain preference.

    Evidence Crystal structures of T1 with monoubiquitin and K48-diubiquitin plus genetic and mutagenesis validation; T2 identified as the Ubp6 docking site

    PMID:26912900

    Open questions at the time
    • Did not enumerate all binding sites on the solenoid
    • Dynamics of substrate hand-off to ATPases unresolved
  6. 2017 Medium

    Confirmed in a native context that Rpn1 is a third intrinsic proteasome ubiquitin receptor alongside Rpn10 and Rpn13.

    Evidence Photoactivatable polyubiquitin crosslinking (UbPT) with MS-based interactome identification

    PMID:28330605

    Open questions at the time
    • Single chemical-tool approach
    • Quantitative contribution relative to Rpn10/Rpn13 not partitioned
  7. 2019 High

    Uncovered phospho-regulation of proteasome assembly through Rpn1, linking a kinase/phosphatase pair to base biogenesis and cellular fitness.

    Evidence CRISPR editing, kinome screen, genetic-code-expansion phosphoserine incorporation, quantitative MS, and Co-IP of the Rpn1-Rpt2 precursor; UBLCP1 as the opposing phosphatase

    PMID:31843888

    Open questions at the time
    • Upstream signals controlling PIM activity on Rpn1 unknown
    • Whether phosphorylation also affects ubiquitin recognition not tested
  8. 2021 High

    Expanded the receptor model to multiple Ub/UBL-binding sites along Rpn1, including a new N-terminal site, and showed competition with Rpn10 for shuttles.

    Evidence NMR spectroscopy, photoactivatable crosslinking, MS, mutagenesis, and competition assays

    PMID:33617881 PMID:34364874

    Open questions at the time
    • Whether each repeat truly forms a functional site in vivo unresolved
    • Functional consequence of inter-receptor competition for degradation kinetics unclear
  9. 2025 Medium

    Established the physiological importance of RPN1's OST function, linking N-glycosylation to meiosis and male fertility.

    Evidence Germ cell-specific conditional Rpn1 knockout in mice with N-glycoproteomics and meiotic/DSB-repair phenotyping

    PMID:40083683

    Open questions at the time
    • Specific glycoprotein substrates driving meiotic defects not pinpointed
    • Single lab; relationship to proteasomal role not addressed
  10. 2026 Medium

    Defined RPN1 as causative for a congenital disorder of glycosylation and pinpointed its C-terminal ribosome-interacting bundle as essential for OST-A activity.

    Evidence Patient lymphoblast biochemistry, OST structural modeling, and substrate-specific glycosylation assays showing OST-A-selective impairment and destabilization of STT3A/RPN2/DDOST

    PMID:39705151 PMID:41203639 PMID:41935956

    Open questions at the time
    • Single patient/single lab for the disease variant
    • Mechanistic interplay between OST-A destabilization and downstream glycoprotein clients incompletely mapped

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RPN1's proteasomal and OST roles are coordinated within a cell, and how its multiple ubiquitin/UBL receptor sites are prioritized during substrate processing, remains unresolved.
  • No unified model connecting proteasome-base and ER-OST functions
  • Substrate selection logic among competing receptor sites unknown
  • In vivo dynamics of shuttle hand-off to the ATPase ring not resolved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0031386 protein tag activity 5 GO:0060090 molecular adaptor activity 4 GO:0016740 transferase activity 3 GO:0005198 structural molecule activity 2
Localization
GO:0005829 cytosol 3 GO:0005783 endoplasmic reticulum 2
Pathway
R-HSA-392499 Metabolism of proteins 4 R-HSA-8953854 Metabolism of RNA 4 R-HSA-8953897 Cellular responses to stimuli 3
Partners
DDI1DSK2NUB1LRAD23RPT2STT3AUBLCP1UBP6
Complex memberships
19S proteasome regulatory particle (base)26S proteasomeoligosaccharyltransferase (OST-A) complex

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 Rpn1, a base subunit of the 19S proteasome regulatory particle, directly binds the ubiquitin-like (UBL) domain of the shuttle protein Rad23 via its leucine-rich-repeat-like (LRR-like) domain, mediating delivery of ubiquitylated cargo to the proteasome. Direct binding assays; identification of Rpn1 as the UBL-binding component within the base subcomplex of the proteasome; competition experiments showing Dsk2 competes with Rad23 for the same Rpn1 LRR-like domain Nature cell biology High 12198498
2016 Rpn1 contains two distinct functional sites within its toroid domain: site T1 recognizes ubiquitin and UBL domains (including substrate shuttling factors) with preference for K48-linked chains, and adjacent site T2 binds the UBL of deubiquitinating enzyme Ubp6 to assist in ubiquitin chain disassembly. Crystal structures of T1 with monoubiquitin and K48-diubiquitin show three neighboring outer helices engaging two ubiquitins. Crystal structure determination of Rpn1 T1 site with monoubiquitin and K48-diubiquitin; genetic identification as a sixth ubiquitin receptor; biochemical binding assays; mutagenesis Science (New York, N.Y.) High 26912900
2012 Rpn1 harbors at least two distinct docking sites for ubiquitin-processing factors: Rad23 and Dsk2 (shuttle proteins carrying UBL domains) dock at two different receptor sites within Rpn1, whereas the deubiquitinase Ubp6 also anchors to Rpn1 but with slower dissociation kinetics, behaving as an occasional proteasome subunit. Rpn10 attaches to the central solenoid of Rpn1 and this association is stabilized by Rpn2. Binding affinity measurements (association/dissociation constants); biochemical reconstitution; pulldown assays distinguishing multiple binding sites on Rpn1 The Journal of biological chemistry High 22318722
2011 A conserved aspartic acid residue D517 in the LRR domain of Rpn1 is required for docking of the UBA-UBL shuttle protein Ddi1 (and to a lesser extent Dsk2) to the proteasome; the rpn1-D517A point mutation strongly impairs delivery of ubiquitin conjugates and blocks degradation of the Ddi1-dependent substrate Ufo1. Rad23 recruitment is not affected by this mutation, indicating distinct docking mechanisms for different shuttle proteins. Site-directed mutagenesis of Rpn1 D517; genetic suppressor screen; in vivo degradation assays for Ddi1-dependent substrate Ufo1; binding assays BMC biology High 21627799
2019 Phosphorylation of Rpn1 at Ser361 by PIM1/2/3 kinases promotes proper assembly of the 26S proteasome; specifically, S361-phosphorylated Rpn1 more readily forms a precursor complex with Rpt2 (an early step of 19S base assembly). The phosphatase UBLCP1 reverses this modification. Loss of S361 phosphorylation reduces proteasome activity, impairs cell proliferation, and causes oxidative stress and mitochondrial dysfunction. CRISPR/Cas9-mediated gene editing; quantitative mass spectrometry; kinome screen identifying PIM1/2/3 as writers; genetic code expansion to incorporate phosphoserine directly; co-immunoprecipitation of Rpn1-Rpt2 precursor complex Proceedings of the National Academy of Sciences of the United States of America High 31843888
2012 Human Rpn1/S2 (proteasomal subunit) binds the shuttle protein NUB1L; this interaction enables proteasome-mediated degradation of FAT10-conjugated substrates. NUB1L can bind to both Rpn10 and Rpn1. Co-immunoprecipitation; yeast complementation assay; depletion of hRpn10 in human cells causing accumulation of FAT10-conjugates Nature communications Medium 22434192
2002 Structural modeling predicts that the repeat-containing domains of Rpn1 and Rpn2 adopt a novel alpha-helical toroid architecture with a central pore, positioned along the common axial pore of the ATPase hexamer to form an 'antechamber' of the 26S proteasome that may assist ATPases in unfolding protein substrates. Computational sequence analysis and molecular modeling of proteasome/cyclosome repeats; identification of strongly curved alpha-helical solenoid structural pattern The Journal of biological chemistry Low 12270919
2013 The UBL domain of human UBLCP1 (a proteasome-associated phosphatase) interacts with the C-terminal leucine-rich repeat-like domain of Rpn1; NMR solution structure of the UBLCP1 UBL domain revealed a unique β3-α2 loop whose positively charged residues mediate this interaction. NMR solution structure determination of UBL domain; NMR binding interaction mapping with Rpn1 LRR-like domain PloS one Medium 23667555
2017 Using photoactivatable crosslinking polyubiquitin reagents (UbPT), Rpn1 was identified as a third proteasome ubiquitin-associating subunit (alongside Rpn10 and Rpn13) that coordinates docking of substrate shuttles, unloading of substrates, and anchoring of polyubiquitin conjugates. Synthetic photoactivatable ubiquitin crosslinking (UbPT); mass spectrometry-based interactome identification; biochemical validation Cell chemical biology Medium 28330605
2021 Rpn1 contains a second, previously uncharacterized ubiquitin/UBL-binding site located in the N-terminal section of Rpn1 (a stretch of adjacent helices), with affinities and binding preferences for polyubiquitin and UBL signals comparable to the known T1 site; binding sites on Rpn1 can be shared among Ub and UBL species, and Rpn1 and Rpn10 can compete for binding of shuttle protein Dsk2. NMR spectroscopy; photoactivatable crosslinking; mass spectrometry; mutagenesis; competition assays The Journal of biological chemistry High 34364874
2021 NMR spectroscopy combined with competition assays showed that Rpn1 associates with UBL-containing proteins and polyubiquitin chains with a preference for shuttle protein Rad23, and that Rpn1 appears to contain multiple Ub/UBL-binding sites (potentially one per proteasome/cyclosome repeat), ruling out exclusive recognition sites for individual Ub/UBL signals. NMR spectroscopy; competition binding assays The Journal of biological chemistry Medium 33617881
2000 T. cruzi Rpn1 (a proteasomal regulatory-particle non-ATPase subunit 1) functionally complements the temperature-sensitive nas1 yeast mutant, rescuing growth at restrictive temperature and indicating that Rpn1 assembles into the 19S regulatory particle of the 26S proteasome. Yeast genetic complementation assay; cloning and functional expression of T. cruzi RPN1 in nas1 temperature-sensitive yeast mutant Molecular and biochemical parasitology Medium 11071286
2025 Germ cell-specific knockout of Rpn1 (ribophorin I, a subunit of the oligosaccharyltransferase complex) in mice disrupts N-glycosylation of endoplasmic reticulum-associated proteins, inhibits meiotic progression, impairs homologous chromosome pairing, meiotic recombination, and DNA double-strand break repair, triggers ER stress, and causes male infertility. Conditional Rpn1 knockout (germ cell-specific); N-glycoproteomic profiling; functional assays for meiosis and DSB repair; ER stress markers International journal of biological sciences Medium 40083683
2026 RPN1 (ribophorin I) mediates post-translational N-glycosylation of PD-L1, enhancing its stability; RPN1 knockdown reduces PD-L1 glycosylation and stability, improving anti-tumor immune responses and the efficacy of anti-PD-1 therapy in triple-negative breast cancer. Co-immunoprecipitation; western blotting; flow cytometry; shRNA knockdown; in vivo tumor experiments International journal of surgery (London, England) Medium 39705151
2025 CERS6 sustains RPN1 stability by inhibiting its ubiquitination; RPN1 in turn activates the IRE1-XBP1 ER stress signaling pathway, and this CERS6-RPN1-IRE1-XBP1 axis promotes ESCC cell proliferation. Co-immunoprecipitation; western blotting; ubiquitination assays; knockdown/overexpression functional experiments in vitro and in vivo Cell death discovery Medium 41203639
2026 A homozygous nonsense variant in RPN1 (ribophorin I) causes a congenital disorder of glycosylation; the truncated RPN1 protein destabilizes other OST complex components (STT3A, RPN2, DDOST) and eliminates a C-terminal four-helix bundle required for ribosome interaction, specifically impairing co-translational glycosylation activity of the OST-A complex while leaving OST-B-specific substrates unaffected. Patient lymphoblast biochemistry; structural modeling of OST-A and OST-B complexes; western blotting of OST complex components; substrate-specific glycosylation assays HGG advances Medium 41935956

Source papers

Stage 0 corpus · 55 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Proteasome subunit Rpn1 binds ubiquitin-like protein domains. Nature cell biology 375 12198498
2012 Reconstitution of abscisic acid activation of SLAC1 anion channel by CPK6 and OST1 kinases and branched ABI1 PP2C phosphatase action. Proceedings of the National Academy of Sciences of the United States of America 341 22689970
2009 Threonine at position 306 of the KAT1 potassium channel is essential for channel activity and is a target site for ABA-activated SnRK2/OST1/SnRK2.6 protein kinase. The Biochemical journal 255 19785574
2016 Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome. Science (New York, N.Y.) 253 26912900
2014 Nitric oxide negatively regulates abscisic acid signaling in guard cells by S-nitrosylation of OST1. Proceedings of the National Academy of Sciences of the United States of America 242 25550508
2015 Aquaporins Contribute to ABA-Triggered Stomatal Closure through OST1-Mediated Phosphorylation. The Plant cell 232 26163575
2010 Ozone-triggered rapid stomatal response involves the production of reactive oxygen species, and is controlled by SLAC1 and OST1. The Plant journal : for cell and molecular biology 205 20128877
2006 Identification of features regulating OST1 kinase activity and OST1 function in guard cells. Plant physiology 189 16766677
2011 Central functions of bicarbonate in S-type anion channel activation and OST1 protein kinase in CO2 signal transduction in guard cell. The EMBO journal 157 21423149
2018 OST1-mediated BTF3L phosphorylation positively regulates CBFs during plant cold responses. The EMBO journal 133 29507081
2012 Rpn1 and Rpn2 coordinate ubiquitin processing factors at proteasome. The Journal of biological chemistry 98 22318722
2022 The tomato OST1-VOZ1 module regulates drought-mediated flowering. The Plant cell 94 35099557
2018 Abscisic acid-independent stomatal CO2 signal transduction pathway and convergence of CO2 and ABA signaling downstream of OST1 kinase. Proceedings of the National Academy of Sciences of the United States of America 83 30282744
2012 FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis. Nature communications 73 22434192
2019 Rheostatic Control of ABA Signaling through HOS15-Mediated OST1 Degradation. Molecular plant 70 31491477
2002 What curves alpha-solenoids? Evidence for an alpha-helical toroid structure of Rpn1 and Rpn2 proteins of the 26 S proteasome. The Journal of biological chemistry 64 12270919
2018 Danger-Associated Peptides Close Stomata by OST1-Independent Activation of Anion Channels in Guard Cells. The Plant cell 63 29716993
2011 Identification of a functional docking site in the Rpn1 LRR domain for the UBA-UBL domain protein Ddi1. BMC biology 62 21627799
2020 FRET kinase sensor development reveals SnRK2/OST1 activation by ABA but not by MeJA and high CO2 during stomatal closure. eLife 61 32463362
2015 The HT1 protein kinase is essential for red light-induced stomatal opening and genetically interacts with OST1 in red light and CO2 -induced stomatal movement responses. The New phytologist 58 26192339
2019 Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function. Proceedings of the National Academy of Sciences of the United States of America 46 31843888
2017 Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit. Cell chemical biology 42 28330605
2023 Cell type-specific proteomics uncovers a RAF15-SnRK2.6/OST1 kinase cascade in guard cells. Journal of integrative plant biology 31 37226855
2003 Association of 3q21q26 syndrome with different RPN1/EVI1 fusion transcripts. Haematologica 28 14607750
2018 ABA-mediated regulation of stomatal density is OST1-independent. Plant direct 26 31245747
2011 [Novel reference gene RPN1 for normalization of quantitative data in lung and kidney cancer]. Molekuliarnaia biologiia 26 21634111
2020 Receptor-like protein kinases RPK1 and BAK1 sequentially form complexes with the cytoplasmic kinase OST1 to regulate ABA-induced stomatal closure. Journal of experimental botany 25 31665747
2013 The maize OST1 kinase homolog phosphorylates and regulates the maize SNAC1-type transcription factor. PloS one 24 23469147
2024 Stomatal opening under high temperatures is controlled by the OST1-regulated TOT3-AHA1 module. Nature plants 23 39613896
2000 Glycosylation of phytepsin and expression of dad1, dad2 and ost1 during onset of cell death in germinating barley scutella. Mechanisms of development 23 10781951
2018 OST1 Activation by the Brassinosteroid-Regulated Kinase CDG1-LIKE1 in Stomatal Closure. The Plant cell 19 30065046
2021 A novel recognition site for polyubiquitin and ubiquitin-like signals in an unexpected region of proteasomal subunit Rpn1. The Journal of biological chemistry 17 34364874
2010 Development of a dual-color, double fusion FISH assay to detect RPN1/EVI1 gene fusion associated with inv(3), t(3;3), and ins(3;3) in patients with myelodysplasia and acute myeloid leukemia. American journal of hematology 17 20556821
2022 Beyond stress response: OST1 opening doors for plants to grow. Stress biology 16 37676544
2024 Disulfidptosis-related Protein RPN1 may be a Novel Anti-osteoporosis Target of Kaempferol. Combinatorial chemistry & high throughput screening 13 38213143
2024 RPN1 promotes the proliferation and invasion of breast cancer cells by activating the PI3K/AKT/mTOR signaling pathway. Discover oncology 10 38302629
2023 Circ-SNX27 sponging miR-375/RPN1 axis contributes to hepatocellular carcinoma progression. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 10 37386831
2021 Polyubiquitin and ubiquitin-like signals share common recognition sites on proteasomal subunit Rpn1. The Journal of biological chemistry 9 33617881
2025 Loss of RPN1 promotes antitumor immunity via PD-L1 checkpoint blockade in triple-negative breast cancer - experimental studies. International journal of surgery (London, England) 8 39705151
2024 RPN1: a pan-cancer biomarker and disulfidptosis regulator. Translational cancer research 8 38881923
2024 Multi-Omics Insights into Disulfidptosis-Related Genes Reveal RPN1 as a Therapeutic Target for Liver Cancer. Biomolecules 8 38927080
2000 Cloning and functional expression of Rpn1, a regulatory-particle non-ATPase subunit 1, of proteasome from Trypanosoma cruzi. Molecular and biochemical parasitology 8 11071286
2013 Solution structure and Rpn1 interaction of the UBL domain of human RNA polymerase II C-terminal domain phosphatase. PloS one 7 23667555
2024 Integrated analysis of disulfidptosis-related genes SLC7A11, SLC3A2, RPN1 and NCKAP1 across cancers. Discover oncology 5 39612126
2023 Plants lacking OST1 show conditional stomatal closure and wildtype-like growth sensitivity at high VPD. Physiologia plantarum 5 37882302
2025 Exploring the impact of RPN1 on tumorigenesis and immune response in cancer. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 3 40079196
2025 Dysregulation of N-glycosylation by Rpn1 knockout in spermatocytes induces male infertility via endoplasmic reticulum stress in mice. International journal of biological sciences 2 40083683
2025 Disulfidptosis-related genes RPN1 inhibits the progression of hepatocellular carcinoma by regulating cell cycle, may be a new therapeutic targets. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2 40691521
2026 Pohsphorylation of MAP4K1 and MAP4K2 by OST1 is required for drought tolerance. The Plant journal : for cell and molecular biology 1 41640200
2025 RPN1 Is Associated With Immunosuppression in Pan-Cancer and Affects the Malignant Phenotype of Tumor. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1 40857034
2025 CERS6 promotes esophageal squamous cell carcinoma proliferation by increasing the stability of RPN1. Cell death discovery 1 41203639
2024 Dissecting the functions and regulatory mechanisms of disulfidoptosis-related RPN1 in pan-cancer: modulation of immune microenvironment and cellular senescence. Frontiers in immunology 1 39749324
2026 Design, synthesis, and antitumor activity of novel Flavokawain A derivatives by suppressing LRPPRC-YBX1-RPN1 cascade. Bioorganic chemistry 0 41529605
2026 A homozygous nonsense variant in the oligosaccharyltransferase complex gene, RPN1, causes a congenital disorder of glycosylation. HGG advances 0 41935956
2026 StWRKY46 promotes stomatal closure and enhances potato drought tolerance by mediating the PYL1-ABI2-OST1/SnRK2.5/SnRK2.6 pathway. Plant physiology 0 42090565

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