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RPL18

Large ribosomal subunit protein eL18 · UniProt Q07020

Length
188 aa
Mass
21.6 kDa
Annotated
2026-06-10
53 papers in source corpus 18 papers cited in narrative 18 extracted findings
Cross-family judge vs UniProt: tie faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RPL18 (bacterial L18) is a structural ribosomal protein whose core function is the recognition and conformational stabilization of 5S rRNA during large-subunit assembly (PMID:2472486, PMID:333392). It binds 5S rRNA at the junctions of helix II and internal loops A and B, with an unpaired adenosine (A66) in helix II serving as a key recognition determinant (PMID:2472486, PMID:2990903); binding induces a conformational change in loop A that licenses cooperative recruitment of L5 to helix I, and the basic N-terminal region — dispensable for 5S rRNA binding itself — is essential for stimulating L5 binding and for mediating 5S rRNA–23S rRNA complex assembly (PMID:2472486, PMID:6159586, PMID:353728). The protein adopts a mixed alpha/beta globular fold with a disordered N-terminus and a conserved RNA-contacting beta-sheet bulge (PMID:11964156), and phosphorylation of a conserved serine stabilizes the native fold required for 5S rRNA binding (PMID:10529214). Beyond its assembly role, RPL18 binds PKR and competes with double-stranded RNA for PKR's first dsRNA-binding domain, inhibiting PKR autophosphorylation and eIF-2alpha phosphorylation and thereby stimulating translation (PMID:9891046). A stress-induced cytosolic isoform initiated from a downstream CUG codon incorporates into 80S ribosomes and promotes translation of heat-shock mRNAs, while a mitochondrial form acts with rhodanese to import cytosolic 5S rRNA into mitochondria (PMID:21685364, PMID:25866880). RPL18 is repeatedly co-opted by viruses — dengue, IBDV, PEDV, and Newcastle disease virus — to support viral protein translation and replication (PMID:26092250, PMID:36084747, PMID:34859725), and in melanoma it stabilizes BTF3 mRNA to activate STAT3 signaling driving proliferation, drug resistance, and M2 macrophage polarization (PMID:41550725). Loss of Rpl18 produces a Diamond-Blackfan-anemia-like erythroid maturation defect with p53 and JAK2-STAT3 activation (PMID:32075953).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1977 Medium

    Establishing that L18 is not merely an inert subunit but actively reshapes its RNA target answered whether the protein contributes to 5S rRNA architecture.

    Evidence Circular dichroism and UV thermal denaturation of L18–5S RNA complexes in E. coli

    PMID:333392

    Open questions at the time
    • Did not localize the structural change to specific RNA elements
    • No residue-level binding map
  2. 1980 Medium

    Dissecting which part of L18 does what separated the 5S-binding function from the assembly-bridging function, defining the basic N-terminus as an RNA-RNA coupling module.

    Evidence Limited trypsin digestion and reconstitution assays in E. coli (also residues 18–117 minimal binding region defined, #13)

    PMID:353728 PMID:6159586

    Open questions at the time
    • Did not show direct N-terminus–23S RNA contact
    • Mechanism of L5 stimulation unresolved
  3. 1985 Medium

    Pinpointing A66 of helix II as a recognition site answered which 5S rRNA nucleotide L18 reads out.

    Evidence Site-directed deletion of A66 and binding assays in E. coli (binding-site mapping by alpha-sarcin protection, #7; iodination of tyrosine at the interface, #15)

    PMID:2990903 PMID:6364140 PMID:7011398

    Open questions at the time
    • A66/Gln19 contact remained a model, not a structure
    • Tyrosine interface evidence rests on a single chemical-modification method
  4. 1989 High

    Showing that L18 binding remodels loop A to enable cooperative L5 recruitment established the protein as an ordered-assembly driver, not a passive binder.

    Evidence Ribonuclease/chemical probing, 5S RNA mutagenesis, and CD in E. coli

    PMID:2472486

    Open questions at the time
    • No co-complex structure of L18–L5–5S RNA
    • Quantitative cooperativity parameters not defined
  5. 1999 Medium

    Identifying that serine phosphorylation is required for L18 folding and 5S rRNA binding answered how the binding-competent conformation is achieved.

    Evidence Phosphoserine biochemistry, Mg2+-dependent pKa measurement, and binding assay with dephosphorylated protein in B. stearothermophilus

    PMID:10529214

    Open questions at the time
    • Responsible kinase/phosphatase not identified
    • Relevance to eukaryotic RPL18 not tested
  6. 1999 High

    The discovery that L18 binds and inhibits PKR revealed a moonlighting function in translational control distinct from ribosome assembly.

    Evidence Co-IP, in vitro kinase assays, K64E mutagenesis, and reporter translation assays

    PMID:9891046

    Open questions at the time
    • Physiological conditions triggering PKR competition unclear
    • Stoichiometry of free vs ribosome-bound RPL18 unknown
  7. 2002 Medium

    The solution structure provided the fold underlying RNA recognition, identifying a conserved beta-sheet bulge as the RNA-contact surface.

    Evidence NMR structure of T. thermophilus L18 with comparison to RNA-bound structures

    PMID:11964156

    Open questions at the time
    • No mutagenesis validation in this study
    • Disordered N-terminus not resolved structurally
  8. 2011 High

    Demonstrating that the mitochondrial form imports cytosolic 5S rRNA established an unexpected RNA-trafficking role for the protein.

    Evidence Biochemical fractionation, Co-IP, and RNA import assays with rhodanese

    PMID:21685364

    Open questions at the time
    • Functional necessity of imported 5S rRNA inside mitochondria not fully defined
    • Import directionality determinants unclear
  9. 2015 High

    Finding a CUG-initiated cytosolic isoform that joins 80S ribosomes to translate heat-shock mRNAs revealed isoform-specific control of stress translation.

    Evidence Reporter assays, polysome profiling, ribosome fractionation, knockdown, and metabolic labeling

    PMID:25866880

    Open questions at the time
    • Mechanism of mRNA selectivity for HSPs unresolved
    • How the isoform alters ribosome behavior not structurally defined
  10. 2020 Medium

    Linking Rpl18 loss to erythroid defects with p53 and JAK2-STAT3 activation connected the gene to ribosomopathy phenotypes.

    Evidence CRISPR/Cas9 knockout in zebrafish with pharmacologic JAK2/STAT3 rescue

    PMID:32075953

    Open questions at the time
    • Human Diamond-Blackfan anemia causation by RPL18 not established here
    • How ribosome insufficiency triggers JAK2-STAT3 unclear
  11. 2022 Medium

    Multiple host-pathogen studies converged on RPL18 as a virus-exploited translation factor, answering whether viruses hijack it for protein synthesis specifically.

    Evidence siRNA knockdown/overexpression with translation-vs-replication readouts for PEDV and NDV (dengue NS1 interaction and redistribution, #3; IBDV VP3/chPKR interaction, #5)

    PMID:26092250 PMID:29273342 PMID:34859725 PMID:36084747

    Open questions at the time
    • Whether viral exploitation uses the PKR-inhibitory or the ribosomal function is unresolved
    • Direct viral RNA–RPL18 contacts not mapped
  12. 2025 Medium

    The BTF3–STAT3 axis defined a pro-tumorigenic mRNA-stabilizing role for RPL18 in melanoma.

    Evidence Melanoma cell lines, patient-derived organoids, xenografts, mRNA stability assays, and STAT3 inhibition

    PMID:41550725

    Open questions at the time
    • Mechanism by which RPL18 stabilizes BTF3 mRNA unknown
    • Whether this is ribosome-dependent or an extra-ribosomal activity unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • It remains unresolved whether RPL18's diverse extra-ribosomal activities (PKR inhibition, viral co-option, BTF3 stabilization, STAT3 activation) reflect a single biochemical property or distinct mechanisms of the same protein.
  • No unifying structural or biochemical model linking ribosomal and moonlighting functions
  • Eukaryotic RPL18–5S rRNA contacts not directly mapped in human

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 5 GO:0005198 structural molecule activity 3 GO:0045182 translation regulator activity 2 GO:0098772 molecular function regulator activity 1
Localization
GO:0005840 ribosome 2 GO:0005739 mitochondrion 1 GO:0005829 cytosol 1
Pathway
R-HSA-1643685 Disease 4 R-HSA-168256 Immune System 2 R-HSA-8953854 Metabolism of RNA 2
Partners
5S RRNABTF3DENGUE NS1IBDV VP3L5PKRRHODANESESTAT3
Complex memberships
5S rRNA ribonucleoprotein60S/50S large ribosomal subunit80S ribosomemitochondrial ribosome

Evidence

Reading pass · 18 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1999 RPL18 (L18) binds to PKR and competes with dsRNA for binding to PKR's first dsRNA binding domain (K64 region), inhibiting both PKR autophosphorylation and PKR-mediated phosphorylation of eIF-2alpha in vitro. Overexpression of L18 reduced eIF-2alpha phosphorylation and stimulated translation in vivo. Co-immunoprecipitation, in vitro kinase assay, site-directed mutagenesis (K64E), transient transfection with reporter gene Molecular and cellular biology High 9891046
2011 Mitochondrial ribosomal protein L18 (MRPL18) acts as an import factor that, together with rhodanese, forms a molecular conveyor to redirect cytosolic 5S rRNA into mitochondria, where it associates with mitochondrial ribosomes. Biochemical fractionation, co-immunoprecipitation, RNA import assays, mitochondrial ribosome association assays Genes & development High 21685364
2015 MRPL18 contains a downstream CUG start codon and generates a cytosolic isoform in a stress-dependent manner; this cytosolic MRPL18 incorporates into the 80S ribosome and facilitates ribosome engagement on stress-selected mRNAs (HSPs), with knockdown substantially dampening cytosolic HSP expression at the translational level. Reporter assays, polysome profiling, ribosome fractionation, siRNA knockdown, metabolic labeling Nature structural & molecular biology High 25866880
2015 RPL18 interacts with dengue virus NS1 protein and is redistributed to the perinuclear region after 48 h post-infection; silencing RPL18 reduces viral translation, replication, and viral yield without affecting overall cell translation efficiency or viability. Affinity chromatography, immunoprecipitation, siRNA knockdown, immunofluorescence, viral yield assay Virology Medium 26092250
2020 Rpl18 deficiency in zebrafish (CRISPR/Cas9 knockout) causes erythroid maturation defects mirroring Diamond-Blackfan anemia, with increased p53 activation and elevated JAK2-STAT3 activity; pharmacologic inhibition of JAK2 or STAT3 rescues anemia in rpl18 mutants. CRISPR/Cas9 knockout in zebrafish, pharmacologic inhibition (JAK2/STAT3 inhibitors), erythroid differentiation assays Cell death & disease Medium 32075953
2017 Chicken RPL18 interacts with IBDV VP3 and chicken PKR (chPKR) in host cells; knockdown of chRPL18 by RNAi promotes type I interferon expression and inhibits IBDV replication, indicating chRPL18 modulates antiviral signaling in association with VP3 and chPKR. Co-immunoprecipitation, RNAi knockdown, interferon expression assay, viral replication assay Virus research Medium 29273342
2025 RPL18 stabilizes BTF3 mRNA, leading to increased BTF3 expression and activation of STAT3 signaling in melanoma cells, promoting proliferation, migration, and temozolomide resistance; RPL18-driven STAT3 activation also increases TGF-β secretion and induces M2 macrophage polarization. Pharmacologic STAT3 inhibition suppresses these phenotypes. Melanoma cell lines, patient-derived organoids, xenograft models, mRNA stability assays, pharmacologic STAT3 inhibition iScience Medium 41550725
1984 E. coli ribosomal protein L18 binds 5S rRNA at specific sites; alpha-sarcin nuclease protection confirmed the binding site on 5S rRNA for L18 (and L25), establishing a direct RNA-protein interaction. Nuclease protection assay (alpha-sarcin ribonuclease), ribonucleoprotein complex analysis Proceedings of the National Academy of Sciences of the United States of America Medium 6364140
1989 Protein L18 binds primarily at the junctions of helix II and internal loops A and B in E. coli 5S RNA; L18 binding induces a conformational change in loop A that contributes to cooperative binding of L5 to helix I, and the basic N-terminal peptide of L18 interacts within the minor groove of helix I. Ribonuclease and chemical probing, site-directed mutagenesis of 5S RNA, circular dichroism Journal of molecular biology High 2472486
1980 The basic N-terminal region of L18 is accessible to trypsin in 5S RNA complexes, is not required for 5S RNA binding per se, but is essential for stimulating L5 binding and for 5S RNA–23S RNA complex formation; in 5S RNA–23S RNA complexes, L18 becomes strongly resistant to proteolysis. Limited trypsin digestion, ribosome reconstitution, RNA-protein and RNA-RNA complex assembly assays Nucleic acids research Medium 6159586
1985 Deletion of adenosine-66 from helix II of E. coli 5S RNA substantially weakens L18 binding, indicating that this unpaired nucleotide is a recognition site for L18; a tentative model proposes interaction between A66/G67 of RNA and glutamine-19 of L18. Site-directed mutagenesis (deletion of A66), protein-RNA binding assay The EMBO journal Medium 2990903
1999 Phosphorylation of a serine residue in Bacillus stearothermophilus L18 is required for proper protein folding and for 5S rRNA binding; dephosphorylated L18 does not bind 5S rRNA at neutral pH, and the dianionic phosphate stabilizes the native conformation, an effect modulated by Mg2+. Biochemical characterization of phosphoserine, Mg2+-dependent pKa measurement, RNA binding assay with dephosphorylated protein Biochemistry Medium 10529214
2002 The solution structure of Thermus thermophilus L18 revealed a mixed alpha/beta globular structure with a disordered N-terminal region; comparison with RNA-complexed L18 structures identified conserved RNA-recognition features including a bulge in the RNA-contacting beta-sheet, suggesting a conserved RNA-binding fold. NMR solution structure determination, structural comparison with known L18 structures The Biochemical journal Medium 11964156
1978 The minimal 5S RNA binding region of E. coli L18 spans approximately residues 18–117; the basic N-terminal region (residues 1–17) is not required for 5S RNA association but is accessible in the L18–5S RNA complex, suggesting it may mediate 5S RNA interaction with 23S RNA. Limited trypsin digestion of L18–5S RNA complex, 5S RNA binding assay with protein fragments Nucleic acids research Medium 353728
1977 Protein L18 binding to 5S RNA induces a 20% increase in the 267 nm circular dichroism band (indicating increased secondary/possible tertiary structure of 5S RNA) and removes the pre-melting behavior in UV absorbance thermal denaturation, demonstrating that L18 stabilizes 5S RNA conformation. Circular dichroism spectroscopy, UV absorbance thermal denaturation Nucleic acids research Medium 333392
1981 Iodination of tyrosine residue(s) in E. coli L18 abolishes 5S RNA binding activity; L18 pre-bound to 5S RNA is protected from iodination, indicating tyrosine is at or near the RNA binding interface. Chemical modification (iodination, tetranitromethane treatment), 5S RNA binding assay Biochimica et biophysica acta Low 7011398
2022 RPL18 is upregulated in PEDV N protein-induced S-phase arrested cells and promotes PEDV replication; siRNA knockdown or overexpression of RPL18 respectively decreased or increased PEDV viral protein levels, indicating RPL18 promotes viral protein synthesis. Quantitative proteomics (TMT-labeling), siRNA knockdown, overexpression, viral replication assay Virus research Medium 36084747
2022 Newcastle disease virus matrix (M) protein increases RPL18 expression in a dose-dependent manner; siRNA knockdown of RPL18 reduces NDV replication by decreasing viral protein translation (not viral RNA synthesis), while RPL18 overexpression enhances NDV replication. siRNA knockdown, overexpression, viral protein translation vs. RNA synthesis assays, plasmid transfection Avian pathology Medium 34859725

Source papers

Stage 0 corpus · 53 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
1978 Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 60 S ribosomal subunit proteins La, Lb, Lf, P1, P2, L13', L14, L18', L20, and L38. The Journal of biological chemistry 112 621213
2011 Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18. Genes & development 95 21685364
1999 Double-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18. Molecular and cellular biology 73 9891046
2015 Translational control of the cytosolic stress response by mitochondrial ribosomal protein L18. Nature structural & molecular biology 71 25866880
1984 Nuclease protection analysis of ribonucleoprotein complexes: use of the cytotoxic ribonuclease alpha-sarcin to determine the binding sites for Escherichia coli ribosomal proteins L5, L18, and L25 on 5S rRNA. Proceedings of the National Academy of Sciences of the United States of America 69 6364140
1977 Isolation of eukaryotic ribosomal proteins. Purification and characterization of 60 S ribosomal subunit proteins L3, L6, L7', L8, L10, L15, L17, L18, L19, L23', L25, L27', L28, L29, L31, L32, L34, L35, L36, L36', and L37'. The Journal of biological chemistry 68 863909
2015 Dengue virus NS1 protein interacts with the ribosomal protein RPL18: this interaction is required for viral translation and replication in Huh-7 cells. Virology 67 26092250
1979 A ribonuclease-resistant region of 5S RNA and its relation to the RNA binding sites of proteins L18 and L25. Nucleic acids research 66 379819
1977 Escherichia coli 5S RNA binding proteins L18 and L25 interact with 5.8S RNA but not with 5S RNA from yeast ribosomes. Proceedings of the National Academy of Sciences of the United States of America 54 142985
2011 Bioactive metabolites from Chaetomium globosum L18, an endophytic fungus in the medicinal plant Curcuma wenyujin. Phytomedicine : international journal of phytotherapy and phytopharmacology 45 22112725
1976 RNA sequences associated with proteins L1, L9, and L5, L18, L25, in ribonucleoprotein fragments isolated from the 50-S subunit of Escherichia coli ribosomes. European journal of biochemistry 42 827440
1977 Alteration of 5S RNA conformation by ribosomal proteins L18 and L25. Nucleic acids research 41 333392
2018 Ribosomal protein L18 is an essential factor that promote rice stripe virus accumulation in small brown planthopper. Virus research 40 29374519
1985 Does unpaired adenosine-66 from helix II of Escherichia coli 5S RNA bind to protein L18? The EMBO journal 35 2990903
1987 Augmentation of immune responses by a muramyl dipeptide analog, MDP-Lys(L18). Agents and actions 32 3318323
1989 Protein L18 binds primarily at the junctions of helix II and internal loops A and B in Escherichia coli 5 S RNA. Implications for 5 S RNA structure. Journal of molecular biology 31 2472486
1984 Isolation and characterization of four mouse ribosomal-protein-L18 genes that appear to be processed pseudogenes. Gene 30 6149171
2023 Beneficial effects of GABA-producing potential probiotic Limosilactobacillus fermentum L18 of human origin on intestinal permeability and human gut microbiota. Microbial cell factories 24 38087304
1987 The complete amino acid sequences of the 5 S rRNA binding proteins L5 and L18 from the moderate thermophile Bacillus stearothermophilus ribosome. FEBS letters 24 3542562
1978 Fragment of protein L18 from the Escherichia coli ribosome that contains the 5S RNA binding site. Nucleic acids research 23 353728
1982 Structural analyses of E. coli 5S RNA fragments, their associates and complexes with proteins L18 and L25. Nucleic acids research 21 6278442
2011 A synthetic NOD2 agonist, muramyl dipeptide (MDP)-Lys (L18) and IFN-β synergistically induce dendritic cell maturation with augmented IL-12 production and suppress melanoma growth. Journal of dermatological science 20 21411292
1980 The role of the basic N-terminal region of protein L18 in 5S RNA-23S RNA complex formation. Nucleic acids research 20 6159586
2017 The association of ribosomal protein L18 (RPL18) with infectious bursal disease virus viral protein VP3 enhances viral replication. Virus research 18 29273342
2020 The nuclear gene rpl18 regulates erythroid maturation via JAK2-STAT3 signaling in zebrafish model of Diamond-Blackfan anemia. Cell death & disease 17 32075953
1980 Purification of Drosophila ribosomal proteins. Isolation of proteins S8, S13, S14, S16, S19, S20/L24, S22/L26, S24, S25/S27, S26, S29, L4, L10/L11, L12, L13, L16, L18, L19, L27, 1, 7/8, 9, and 11. Biochemistry 16 6773542
1988 The primary structure of rat ribosomal protein L18. DNA (Mary Ann Liebert, Inc.) 15 3371159
1988 Exploration of the L18 binding site on 5S RNA by deletion mutagenesis. Nucleic acids research 13 3060848
2002 The solution structure of ribosomal protein L18 from Thermus thermophilus reveals a conserved RNA-binding fold. The Biochemical journal 12 11964156
1999 Phosphorylation of ribosomal protein L18 is required for its folding and binding to 5S rRNA. Biochemistry 11 10529214
1993 Nucleotide and deduced amino acid sequence of human ribosomal protein L18. Biochimica et biophysica acta 11 8218404
1977 Small-angle X-ray titration study on the complex formation between 5-S RNA and the L18 protein of the Escherichia coli 50-S ribosome particle. European journal of biochemistry 11 334548
2022 Up-regulated 60S ribosomal protein L18 in PEDV N protein-induced S-phase arrested host cells promotes viral replication. Virus research 10 36084747
2022 The association of ribosomal protein L18 with Newcastle disease virus matrix protein enhances viral translation and replication. Avian pathology : journal of the W.V.P.A 9 34859725
2021 Characterization of β-glucosidase of Lactobacillus plantarum FSO1 and Candida pelliculosa L18 isolated from traditional fermented green olive. Journal, genetic engineering & biotechnology 8 34370148
2000 Intrapleural therapy with MDP-Lys (L18), a synthetic derivative of muramyl dipeptide, against malignant pleurisy associated with lung cancer. Lung cancer (Amsterdam, Netherlands) 8 10688489
2024 Identification of the ribosomal protein L18 (RPL18) gene family reveals that TaRPL18-1 positively regulates powdery mildew resistance in wheat. International journal of biological macromolecules 7 39322125
2018 Cre-miR914-regulated RPL18 is involved with UV-B adaptation in Chlamydomonas reinhardtii. Journal of plant physiology 7 30537602
2004 The solution structure of ribosomal protein L18 from Bacillus stearothermophilus. Journal of molecular biology 7 14687565
1992 In vitro and in vivo effects of MDP-Lys(L18) on mouse megakaryocyte progenitor cells (CFU-Meg). Experimental hematology 7 1568468
2001 [The Thermus thermophilus 5S rRNA-protein complex: Identifications of specific binding sites for proteins L5 and L18 in 5S rRNA]. Molekuliarnaia biologiia 6 11524947
1996 Inflammatory cytokine production induced by an analogue of muramyl dipeptide MDP-Lys(L18) in rat macrophage cultures and dog synovial fluid. Inflammation 6 8926048
1996 Sequence, overproduction and purification of Vibrio proteolyticus ribosomal protein L18 for in vitro and in vivo studies. Gene 6 8996113
2001 Gene structure and promoter function of a teleost ribosomal protein: a tilapia (Oreochromis mossambicus) L18 gene. Biochimica et biophysica acta 5 11566355
2023 Decreased expression of RPL15 and RPL18 exacerbated the calcification of valve interstitial cells during aortic valve calcification. Cell biology international 4 37431269
2022 [Prevalence, Diversity, and Evolution of L18 (DD37E) Transposons in the Genomes of Cnidarians]. Molekuliarnaia biologiia 4 35621103
1996 The cloning and sequencing of a ribosomal L18 protein from an evolutionary divergent eukaryote, Trypanosoma brucei. Biochimica et biophysica acta 4 8950179
1993 Sequence analysis of mouse cDNAs encoding ribosomal proteins L12 and L18. Gene 4 8359697
2024 CD62-L down-regulation after L18-MDP stimulation as a complementary flow cytometry functional assay for the diagnosis of XIAP deficiency. Cytometry. Part B, Clinical cytometry 3 38770762
2021 Molecular characterization and expression analysis of ribosomal L18/L5e gene in Pennisetum glaucum (L.) R. Br. Saudi journal of biological sciences 3 34121902
1981 Iodination of Escherichia coli ribosomal protein L18 abolishes its 5 S RNA binding activity. Biochimica et biophysica acta 2 7011398
2026 Integrated transcriptomic and metabolomic analyses reveal the antibacterial mechanism of whey fermentation powder against Bacillus cereus L18 and its efficacy in Liangpi preservation. Food research international (Ottawa, Ont.) 0 41794485
2025 RPL18 promotes melanoma progression and drug resistance via BTF3/STAT3-dependent mechanisms and immune modulation. iScience 0 41550725

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