Affinage

RITA1

RBPJ-interacting and tubulin-associated protein 1 · UniProt Q96K30

Length
269 aa
Mass
28.6 kDa
Annotated
2026-04-28
90 papers in source corpus 10 papers cited in narrative 10 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RITA1 is a multifunctional protein that negatively regulates Notch signaling and modulates microtubule dynamics during mitosis and cell migration. RITA1 binds RBP-J/CBF-1 through a RAM domain-like interface—confirmed by X-ray crystallography—and exports RBP-J from the nucleus to repress Notch target genes; it additionally recruits the E3 ubiquitin ligase TRIM25 to ubiquitinate RBPJ for proteasomal degradation (PMID:21102556, PMID:28487372, PMID:35701858). Through a distinct tubulin-binding domain, RITA1 coats microtubules, promotes HDAC6 association with tubulin, and limits TPX2-dependent Aurora A activation at spindle poles, thereby ensuring proper chromosome alignment and segregation (PMID:27721410, PMID:30705408). RITA1 also regulates focal adhesion turnover through interaction with LPP, controlling cell migration and invasion (PMID:31353815).

Mechanistic history

Synthesis pass · year-by-year structured walk · 8 steps
  1. 2010 High

    The central question of whether Notch signaling is modulated by nuclear export of its transcription factor RBP-J was answered by identifying RITA as a cytoplasmic shuttle that binds both RBP-J and tubulin, exports RBP-J from the nucleus, and reverses Notch-induced loss of primary neurogenesis in Xenopus.

    Evidence Reciprocal co-immunoprecipitation, FRAP live-cell imaging, reporter assays, and Xenopus laevis phenotypic rescue

    PMID:21102556

    Open questions at the time
    • Structural basis of RITA–RBP-J interaction undefined
    • Whether RITA's tubulin-binding and RBP-J-binding functions are independent was unclear
    • Mechanism of nuclear export (carrier, NES) not identified
  2. 2014 Medium

    Testing evolutionary conservation, human RITA was shown to bind Drosophila Su(H) and tubulin in vivo, but failed to perturb Notch signaling in flies, defining a species-specific boundary for RITA's nuclear export mechanism.

    Evidence Transgenic fly expression, co-immunoprecipitation, and genetic epistasis in Drosophila

    PMID:25588307

    Open questions at the time
    • Why fly Su(H) binding is insufficient for functional export was not resolved
    • Whether an endogenous Drosophila RITA ortholog exists was not addressed
  3. 2016 High

    RITA's role on microtubules was mechanistically defined: it coats microtubule structures, promotes HDAC6 association with tubulin to regulate acetylation and dynamics, and its loss causes mitotic chromosome misalignment and segregation errors—establishing RITA as a direct regulator of microtubule stability through its tubulin-binding domain.

    Evidence In vitro microtubule binding, RITA KO MEFs, siRNA knockdown, rescue with wild-type vs. Δtub mutant, live-cell imaging

    PMID:27721410

    Open questions at the time
    • Whether RITA directly modulates HDAC6 enzymatic activity or only its recruitment was unclear
    • Structural basis of RITA–tubulin interaction unresolved
  4. 2016 High

    A saRNA-guided transcriptional activation complex (termed 'RITA complex') containing Ago2, RHA, and CTR9 was shown to interact with RNA Pol II to stimulate transcription initiation and elongation with accompanying H2B monoubiquitination, establishing a distinct RNA-guided gene activation mechanism.

    Evidence Mass spectrometry proteomics, reciprocal co-immunoprecipitation, ChIP, RNA pulldown, and reporter assays

    PMID:26902284

    Open questions at the time
    • Relationship between this 'RITA complex' and the RITA1 protein product is nomenclatural—whether RITA1 protein itself is a subunit was not demonstrated
    • Genome-wide target gene repertoire unknown
    • Structural organization of the complex undefined
  5. 2017 High

    The atomic-resolution crystal structure of the RBP-J·RITA·DNA complex revealed that RITA engages RBP-J via a RAM domain-mimicking interface plus additional contact surfaces, and structure-guided mutagenesis confirmed these contacts are required for Notch target gene repression.

    Evidence X-ray crystallography, isothermal titration calorimetry, site-directed mutagenesis, luciferase reporter assays

    PMID:28487372

    Open questions at the time
    • How RITA competes with endogenous Notch-RAM for RBP-J binding in a physiological context was not resolved kinetically
    • Whether RITA simultaneously binds RBP-J and tubulin or these are mutually exclusive was unclear
  6. 2019 High

    RITA was shown to limit TPX2-dependent Aurora A activation at spindle poles: RITA loss hyperactivates Aurora A/TPX2, and Aurora A inhibition rescues the mitotic defects, revealing that RITA fine-tunes spindle assembly by controlling TPX2–microtubule association through its tubulin-binding domain.

    Evidence Co-immunoprecipitation of FLAG-RITA with Aurora A/TPX2/tubulin, KO MEFs, Aurora A kinase assay, rescue with WT vs. Δtub RITA

    PMID:30705408

    Open questions at the time
    • Whether RITA directly binds TPX2 or acts indirectly through tubulin was not fully resolved
    • In vivo consequence for aneuploidy and tumorigenesis not established
  7. 2019 High

    RITA's function was extended to cell migration: its depletion stabilized focal adhesions (elevated active integrin, pFAK, paxillin) and reduced LPP/α-actinin at FAs, impairing motility—establishing RITA as a regulator of focal adhesion turnover through its interaction with LPP.

    Evidence siRNA knockdown in multiple cell lines and KO MEFs, co-immunoprecipitation of RITA with LPP, live-cell FA turnover assays, Boyden chamber and wound healing migration assays

    PMID:31353815

    Open questions at the time
    • Whether the LPP interaction is direct or bridged by another protein was not confirmed with purified components
    • How RITA's tubulin-binding versus RBP-J-binding domains contribute to migration was not dissected
  8. 2022 High

    A second mechanism of RBPJ silencing was uncovered: RITA1 recruits the E3 ligase TRIM25 to ubiquitinate RBPJ, targeting it for proteasomal degradation and suppressing Notch1 downstream targets, linking RITA1 to bladder cancer cell growth.

    Evidence Co-immunoprecipitation, ubiquitination assay, MG132 proteasome inhibitor treatment, shRNA knockdown, xenograft models

    PMID:35701858

    Open questions at the time
    • Whether RITA1's nuclear export and TRIM25-mediated degradation of RBPJ are sequential or independent pathways is unknown
    • Ubiquitination site(s) on RBPJ not mapped
    • In vivo relevance beyond bladder cancer xenografts not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include whether RITA1's RBP-J-binding and tubulin-binding functions are coordinately regulated, the structural basis of RITA1–tubulin interaction, and whether RITA1's contributions to mitotic fidelity and Notch repression converge in developmental or tumor-suppressive contexts.
  • No structural model of RITA1–tubulin complex exists
  • Coordination between nuclear (RBP-J/TRIM25) and cytoplasmic (tubulin/HDAC6/TPX2) functions is unexplored
  • No in vivo genetic models (conditional knockout) have assessed developmental or tumor phenotypes

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 5 GO:0008092 cytoskeletal protein binding 2
Localization
GO:0005634 nucleus 2 GO:0005829 cytosol 2 GO:0005856 cytoskeleton 2 GO:0005815 microtubule organizing center 1
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1640170 Cell Cycle 2 R-HSA-392499 Metabolism of proteins 1
Partners
AURKAHDAC6LPPRBPJTPX2TRIM25
Complex memberships
Aurora A–TPX2–tubulinRITA1–RBP-JRITA1–TRIM25–RBPJ

Evidence

Reading pass · 10 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2010 RITA (C12ORF52/RBP-J interacting and tubulin-associated protein) was identified as a novel RBP-J/CBF-1-interacting protein that binds tubulin in the cytoplasm and shuttles rapidly between cytoplasm and nucleus, functioning to export RBP-J/CBF-1 from the nucleus, thereby acting as a negative modulator of the Notch signalling pathway and reversing Notch-induced loss of primary neurogenesis in Xenopus laevis. Co-immunoprecipitation, live-cell imaging (FRAP), overexpression/knockdown with reporter assays, Xenopus laevis functional rescue experiments The EMBO journal High 21102556
2017 The X-ray crystal structure of the RBP-J·RITA complex bound to DNA was determined, revealing that RITA binds RBP-J similarly to the RAM domain of Notch receptors. Structure-based mutagenesis and isothermal titration calorimetry demonstrated that RITA interacts with additional regions in RBP-J beyond the RAM-like binding site, and the complex formation is required for RITA-mediated repression of Notch target genes. X-ray crystallography, isothermal titration calorimetry, site-directed mutagenesis, co-immunoprecipitation, luciferase reporter assays The Journal of biological chemistry High 28487372
2016 RITA binds to tubulin and localizes to various mitotic microtubule structures, coating microtubules and affecting their structure in vitro and in vivo. Loss of RITA increases acetylated α-tubulin, enhances microtubule stability, reduces microtubule dynamics, and causes multiple mitotic defects including chromosome misalignment and segregation errors. Mechanistically, RITA interacts with tubulin/HDAC6 and its suppression decreases HDAC6 binding to tubulin/microtubules. Re-expression of wild-type RITA but not a tubulin-binding-deficient mutant (RITA Δtub) restores the phenotypes. In vitro microtubule binding assay, co-immunoprecipitation, RITA knockout MEFs, siRNA knockdown, rescue with wild-type vs. mutant RITA, immunofluorescence, live-cell imaging Oncogene High 27721410
2019 RITA depletion reduces cell migration and invasion by stabilizing focal adhesions (FAs) with elevated active integrin, phosphorylated FAK, and paxillin, and disturbed FA turnover. RITA co-precipitates with LPP (lipoma-preferred partner), and its suppression reduces LPP and α-actinin at FAs, compromising actin dynamics. This identifies RITA as a regulator of cell motility through its effects on actin filament and microtubule dynamics. siRNA knockdown in multiple cell lines, co-immunoprecipitation (RITA with LPP), live-cell FA turnover assays, immunofluorescence, migration/invasion assays (Boyden chamber, wound healing) Molecular oncology High 31353815
2019 RITA colocalizes with Aurora A and its activator TPX2 at spindle poles during mitosis, and FLAG-RITA co-precipitates with the Aurora A/TPX2/tubulin complex. RITA depletion increases active Aurora A and TPX2 at spindle poles, and the mitotic failures caused by RITA loss are rescued by Aurora A inhibition. RITA affects the microtubule-binding of TPX2 rather than directly inhibiting Aurora A catalytic activity, and the effect requires RITA's tubulin-binding domain (Δtub mutant fails to rescue). Co-immunoprecipitation (FLAG-RITA with Aurora A/TPX2/tubulin), immunofluorescence, RITA KO MEFs, siRNA knockdown, Aurora A kinase activity assay, rescue with WT vs. Δtub RITA Oncogene High 30705408
2022 RITA1 recruits TRIM25 (an E3 ubiquitin ligase) to ubiquitinate RBPJ, accelerating its proteasomal degradation. This leads to transcriptional inhibition of Notch1 downstream targets and drives bladder cancer cell growth. The RITA1/TRIM25/RBPJ axis was established through tumor microarray, shRNA library screening, co-immunoprecipitation, and proteasome inhibitor experiments. Co-immunoprecipitation, shRNA knockdown, proteasome inhibitor treatment (MG132), ubiquitination assay, gene microarray, xenograft models Cancer science High 35701858
2014 Human RITA binds to Drosophila Su(H) (ortholog of RBP-J) and to tubulin in vivo in Drosophila tissues, as shown by co-immunoprecipitation, and RITA co-localizes with tubulin in fly tissues. However, overexpression of human RITA in Drosophila does not phenotypically affect Notch signaling, suggesting that a Su(H) nuclear export mechanism dependent on RITA may not exist in flies. Transgenic fly expression, co-immunoprecipitation, immunofluorescence co-localization, genetic epistasis Hereditas Medium 25588307
2019 RITA is expressed in trophoblastic cells throughout placental gestation including proliferative villous cytotrophoblasts, syncytiotrophoblast, and extravillous trophoblasts. Depletion of RITA impairs motility and invasion of trophoblastic cell lines and compromises fusion ability of choriocarcinoma-derived trophoblasts, establishing a functional role for RITA in placental development. siRNA knockdown, migration/invasion assays, cell fusion assays, qRT-PCR, immunofluorescence in primary tissue and cell lines Cells Medium 31766533
2013 RITA overexpression in hepatocellular carcinoma (HepG2) cells suppresses cell proliferation and promotes apoptosis, upregulates p53, and reduces cyclin E levels, while RITA knockdown promotes cell growth and has opposite effects on p53 and cyclin E expression. This establishes RITA protein as a functional regulator of cell proliferation in HCC via modulation of p53 and cyclin E. Plasmid overexpression, siRNA knockdown, MTT assay, flow cytometry, qRT-PCR, Western blotting Oncology research Medium 24308154
2016 saRNA-guided Ago2 facilitates assembly of an RNA-induced transcriptional activation (RITA) complex that includes Ago2, RHA, and CTR9 (a PAF1 complex component). The RITA complex interacts with RNA Polymerase II to stimulate transcription initiation and productive elongation, accompanied by monoubiquitination of histone H2B, establishing a cellular RNA-guided transcriptional activation mechanism. Mass spectrometry-based proteomics, co-immunoprecipitation, ChIP, RNA pulldown, reporter assays, siRNA knockdown Cell research High 26902284

Source papers

Stage 0 corpus · 90 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2004 Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nature medicine 640 15558054
2016 saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription. Cell research 111 26902284
2009 Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis. Cancer cell 96 19411072
1994 The rice bZIP transcriptional activator RITA-1 is highly expressed during seed development. The Plant cell 94 7919992
2004 Rita Levi-Montalcini: the discovery of nerve growth factor and modern neurobiology. Trends in cell biology 76 15246433
2010 Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer research 74 20395210
2010 Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA. Cell cycle (Georgetown, Tex.) 69 20436301
2012 Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma. PloS one 62 22276160
2020 European Society for Immunodeficiencies (ESID) and European Reference Network on Rare Primary Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN RITA) Complement Guideline: Deficiencies, Diagnosis, and Management. Journal of clinical immunology 59 32064578
2009 p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA. Cell cycle (Georgetown, Tex.) 58 19838062
2010 RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. The EMBO journal 57 21102556
2013 Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro. Clinical cancer research : an official journal of the American Association for Cancer Research 54 23864164
2014 RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38. Cell death & disease 52 25010984
2012 Drug resistance to inhibitors of the human double minute-2 E3 ligase is mediated by point mutations of p53, but can be overcome with the p53 targeting agent RITA. Molecular cancer therapeutics 49 22933706
2017 RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems. Redox biology 48 28582730
2009 HIPK2 regulation by MDM2 determines tumor cell response to the p53-reactivating drugs nutlin-3 and RITA. Cancer research 45 19638586
2017 Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin. Neoplasia (New York, N.Y.) 44 28284059
2010 RITA inhibits multiple myeloma cell growth through induction of p53-mediated caspase-dependent apoptosis and synergistically enhances nutlin-induced cytotoxic responses. Molecular cancer therapeutics 38 21062913
2013 Pharmacological targeting of p53 through RITA is an effective antitumoral strategy for malignant pleural mesothelioma. Cell cycle (Georgetown, Tex.) 37 24345738
2011 Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX. Cell death and differentiation 33 21546907
2008 Changes in microbial community structure in the wake of Hurricanes Katrina and Rita. Environmental science & technology 32 19174873
2011 Temporal and spatial variability in culturable pathogenic Vibrio spp. in Lake Pontchartrain, Louisiana, following hurricanes Katrina and Rita. Applied and environmental microbiology 31 21642406
2019 p53-Dependent Apoptotic Effect of Puromycin via Binding of Ribosomal Protein L5 and L11 to MDM2 and its Combination Effect with RITA or Doxorubicin. Cancers 30 31022952
2017 Structure-function analysis of RBP-J-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes. The Journal of biological chemistry 30 28487372
2011 Rita Levi-Montalcini and the discovery of NGF, the first nerve cell growth factor. Archives italiennes de biologie 30 21701989
2012 The p53-reactivating small-molecule RITA enhances cisplatin-induced cytotoxicity and apoptosis in head and neck cancer. Cancer letters 29 22634494
2016 Deficiency of RITA results in multiple mitotic defects by affecting microtubule dynamics. Oncogene 26 27721410
2014 The p53-reactivating small molecule RITA induces senescence in head and neck cancer cells. PloS one 24 25119136
2005 Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer. Theoretical biology & medical modelling 24 16174299
2005 Morphology of the pharyngeal cavity, especially the surface ultrastructure of gill arches and gill rakers in relation to the feeding ecology of the catfish Rita rita (Siluriformes, Bagridae). Journal of morphology 23 15971265
2005 Standardized assessment of cell proliferation: the approach of the RITA-CEPA working group. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 22 16325520
2011 Chk2 mediates RITA-induced apoptosis. Cell death and differentiation 20 22158418
2016 Targeting NF-κB RelA/p65 phosphorylation overcomes RITA resistance. Cancer letters 18 27721021
2012 IGF-1R/MDM2 relationship confers enhanced sensitivity to RITA in Ewing sarcoma cells. Molecular cancer therapeutics 18 22461661
2012 Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents. Cell death & disease 18 22476102
2009 [Serological evaluation for detection of anti-Leishmania antibodies in dogs and cats in the district of Santa Rita de Cássia, municipality of Barra Mansa, State of Rio de Janeiro]. Revista da Sociedade Brasileira de Medicina Tropical 18 19448930
2014 RITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53abnormal myeloma cells independently of the p53 pathway. BMC cancer 17 24927749
2013 RITA inhibits growth of human hepatocellular carcinoma through induction of apoptosis. Oncology research 17 24308154
2018 Expression patterns of heat shock protein genes in Rita rita from natural riverine habitat as biomarker response against environmental pollution. Chemosphere 15 30092534
2019 RITA modulates cell migration and invasion by affecting focal adhesion dynamics. Molecular oncology 14 31353815
2015 RITA enhances irradiation-induced apoptosis in p53-defective cervical cancer cells via upregulation of IRE1α/XBP1 signaling. Oncology reports 14 26134873
2011 RITA enhances chemosensivity of pre-B ALL cells to doxorubicin by inducing p53-dependent apoptosis. Hematology (Amsterdam, Netherlands) 13 21756539
2012 2011 Rita Schaffer lecture: nanoparticles for intracellular nucleic acid delivery. Annals of biomedical engineering 12 22451256
2012 Efficient synthesis of RITA and its analogues: derivation of analogues with improved antiproliferative activity via modulation of p53/miR-34a pathway. Organic & biomolecular chemistry 12 23151607
2011 Inability of p53-reactivating compounds Nutlin-3 and RITA to overcome p53 resistance in tumor cells deficient in p53Ser46 phosphorylation. Biochemical and biophysical research communications 12 22166212
2002 Cytochrome P4501A responses in two tropical fish species, riverine catfish (Rita rita) and marine mudfish (Apocryptes bato). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 12 11796326
2022 RITA1 drives the growth of bladder cancer cells by recruiting TRIM25 to facilitate the proteasomal degradation of RBPJ. Cancer science 11 35701858
2015 Proteomic profiling of white muscle from freshwater catfish Rita rita. Fish physiology and biochemistry 11 25810140
2024 Therapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis). Cell death & disease 10 38811536
2018 Study on Therapeutic Action and Mechanism of TMZ Combined with RITA Against Glioblastoma. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 10 30562758
2019 RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity. Cell death & disease 9 31699971
2018 RITA induces apoptosis in p53-null K562 leukemia cells by inhibiting STAT5, Akt, and NF-κB signaling pathways. Anti-cancer drugs 9 30157040
2013 Serous goblet cells: the protein secreting cells in the oral cavity of a catfish, Rita rita (Hamilton, 1822) (Bagridae, Siluriformes). Tissue & cell 9 24008113
1988 Impact of detergents on the protein histochemistry of various cell types of the gill epithelium of Rita rita. Ecotoxicology and environmental safety 9 3378537
2020 Transcriptomic responses to pollution in natural riverine environment in Rita rita. Environmental research 8 32325295
2010 RITA--Registry of Industrial Toxicology Animal data: the application of historical control data for Leydig cell tumors in rats. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 8 20541379
2009 Public talks and science listens: a community-based participatory approach to characterizing environmental health risk perceptions and assessing recovery needs in the wake of hurricanes katrina and rita. Environmental health insights 8 20508756
1999 Identification of ribonucleoprotein (RNP)-specific protein interactions using a yeast RNP interaction trap assay (RITA). BioTechniques 8 10524322
2018 Expression patterns and mutation analysis of p53 in fish Rita rita from polluted riverine environment. Mutation research. Genetic toxicology and environmental mutagenesis 7 30057020
2018 RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism. Cancer letters 7 30447254
2014 Analysis of the interaction between human RITA and Drosophila Suppressor of Hairless. Hereditas 7 25588307
1999 RITA/Registry of Industrial Toxicology Animal data: a comparative immunohistochemical study of 77 islet cell carcinomas in Sprague-Dawley and Wistar rats using antibodies against insulin, glucagon, somatostatin and gastrin. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 7 10661805
2019 Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining In Vivo Antitumor Efficacy. Molecular cancer therapeutics 6 31341033
2017 RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles. ACS medicinal chemistry letters 6 28435526
2013 Homage to Rita Levi-Montalcini, the queen of modern neuroscience. Cell biology international 6 23520136
2007 Preponderance of GC-rich sites in silver-stained nucleolus organizing regions of Rita rita (Hamilton) and Mystus gulio (Hamilton) (Bagridae, Pisces), as revealed by chromomycin A3-staining technique and scanning electron microscopic studies. Genetics and molecular research : GMR 6 17573658
2019 Potential involvement of RITA in the activation of Aurora A at spindle poles during mitosis. Oncogene 5 30705408
2013 The multiple life of nerve growth factor: tribute to rita levi-montalcini (1909-2012). Balkan medical journal 5 25207059
2024 Advancing human genotyping: The Infinium HTS iSelect Custom microarray panel (Rita) development study. Forensic science international. Genetics 4 38653142
2022 Reactivation of p53 by RITA Induces Apoptosis in Human Oral Squamous Cell Carcinoma Cells. Anticancer research 4 35641264
2017 RITA displays anti-tumor activity in medulloblastomas independent of TP53 status. Oncotarget 4 28427187
2011 Lens proteome map and alpha-crystallin profile of the catfish Rita rita. Indian journal of biochemistry & biophysics 4 21469600
2019 RITA Is Expressed in Trophoblastic Cells and Is Involved in Differentiation Processes of the Placenta. Cells 3 31766533
2019 Influence of spermine and nitrogen deficiency on growth and secondary metabolites accumulation in Castilleja tenuiflora Benth. cultured in a RITA® temporary immersion system. Engineering in life sciences 3 32624984
2002 Sublethal temperature stress in juvenile Labeo rohita (Ham-Buch.) and Rita rita (Ham.): some physiological changes. Indian journal of experimental biology 3 12622207
2023 Nucleolar phosphoprotein modifications as a marker of apoptosis induced by RITA treatment. Biochimica et biophysica acta. Molecular cell research 2 37276927
2022 Decreased DNA Damage and Improved p53 Specificity of RITA Analogs. Molecular cancer therapeutics 2 35877475
2015 Complete mitochondrial genome of the Freshwater Catfish Rita rita (Siluriformes, Bagridae). Mitochondrial DNA 2 24409859
1989 Detergent-induced changes in the mapping of certain enzymes in various cell types of Rita rita. I. Opercular epidermis. Ecotoxicology and environmental safety 2 2714220
2025 Ovarian stimulation with follitropin delta is safe and effective: results from the RITA randomized, double-blind, placebo-controlled trials. Fertility and sterility 1 40714031
2021 Rita Levi-Montalcini, NGF Metabolism in Health and in the Alzheimer's Pathology. Advances in experimental medicine and biology 1 34453296
2016 [RITA combined with temozolomide inhibits the proliferation of human glioblastoma U87 cells]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 1 27777210
1990 Detergent-induced changes in the protein constituents of various cell types of opercular epidermis of Rita rita. Biomedical and environmental sciences : BES 1 2252548
1989 Detergent-induced changes in the mapping of certain enzymes in various cell types of Rita rita. II. Gill epithelium. Ecotoxicology and environmental safety 1 2714221
2025 Evaluation of the Novel RITA MTBC Assay for Tuberculosis Detection: A Pilot Comparison with GeneXpert and BD MAX™. Pathogens (Basel, Switzerland) 0 41599005
2024 Rita Levi-Montalcini: From Persecution to the Nobel Prize and an Honorary Degree From a Canadian University. Cureus 0 39429264
2023 [RITA selectively inhibits proliferation of BAP1-deficient cutaneous melanoma cells in vitro]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 0 37313811
2021 [Effect of RITA on TP53 Mutant Human Mantle Cell Lymphoma Cell Line and Its Mechanism]. Zhongguo shi yan xue ye xue za zhi 0 34893110
2016 Identification of differentially expressed genes associated with the enhancement of X-ray susceptibility by RITA in a hypopharyngeal squamous cell carcinoma cell line (FaDu). Radiology and oncology 0 27247549
1989 Toxic effects of an anionic detergent on the lipid constituents of various cell types of the gill epithelium of Rita rita: a histochemical investigation. Biomedical and environmental sciences : BES 0 2604897