Affinage

LPP

Lipoma-preferred partner · UniProt Q93052

Length
612 aa
Mass
65.7 kDa
Annotated
2026-06-10
100 papers in source corpus 21 papers cited in narrative 21 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 8/8 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

LPP (Lipoma Preferred Partner) is a group-3 LIM-domain scaffold protein that couples actin-based adhesion structures to gene transcription, shuttling between focal adhesions and cell-cell contacts and the nucleus to control cell motility, adhesion turnover, and invasion (PMID:8812423, PMID:10637295). It was first identified as the 3q27-28 translocation partner of HMGIC in lipomas, encoding a proline-rich N-terminus with a leucine-zipper and three C-terminal LIM domains (PMID:8812423). The LIM domains and the inter-LIM1/2 linker are the principal focal-adhesion targeting elements and also carry transactivation activity, while a separate N-terminal CRM1-dependent nuclear export signal restricts nuclear accumulation (PMID:10637295, PMID:12441356). At adhesions and junctions, LPP binds VASP through its ActA-repeat region to promote junction assembly and recruits alpha-actinin into detergent-insoluble adhesion networks, an interaction required for adhesion turnover and migration (PMID:10637295, PMID:16613855, PMID:18413140, PMID:23447672). In the nucleus LPP functions as a transcriptional coactivator for the ETS factors PEA3, ER81, and ETV5, occupying ETS-regulated promoters and, with ETV5, directly driving MMP-15 transcription to control N-cadherin cleavage and collective migration (PMID:16738319, PMID:22266854, PMID:26028032). Its trafficking and abundance are signal-responsive: Rho-kinase activity governs focal-adhesion association versus nuclear shuttling, TGFbeta redirects LPP to focal adhesions to license invasion, and Src phosphorylation at Y245/301/302 drives invadopodia formation and metastasis (PMID:12760907, PMID:23447672, PMID:28436416). LPP also associates with the shelterin complex (POT1, TRF2, TIN2) at a subset of telomeres and is required for telomere protection, distinguishing it from the closely related zyxin (PMID:20634563, PMID:21519191). LPP stability is controlled by UBE2S/TRIM21-mediated K11-linked polyubiquitination, which promotes its degradation in bladder cancer (PMID:37422473).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1996 High

    Established the existence and domain architecture of LPP and linked it to lipoma genetics, defining the gene as an HMGIC translocation partner.

    Evidence cDNA cloning, sequencing, FISH and RT-PCR of lipoma fusion transcripts

    PMID:8812423

    Open questions at the time
    • Did not assign a cellular function to the protein
    • Functional consequence of HMGIC/LPP fusion not tested
  2. 2000 High

    Defined LPP as a dually-localized protein, placing it at focal adhesions/cell contacts via VASP binding and in the nucleus via a CRM1-dependent NES, and showed it has intrinsic transactivation capacity.

    Evidence Immunofluorescence, Co-IP, leptomycin B treatment, GAL4 reporter assay

    PMID:10637295

    Open questions at the time
    • Nuclear transcriptional targets not identified
    • Functional relevance of nuclear shuttling unknown
  3. 2002 High

    Mapped the molecular determinants of LPP targeting, showing LIM domains and the LIM1/2 linker drive focal-adhesion localization while being dispensable for nuclear targeting.

    Evidence Domain deletion/mutation constructs with immunofluorescence in cultured cells

    PMID:12441356

    Open questions at the time
    • Sequence determinant of nuclear import not defined
    • Endogenous depletion effects only shown by overexpression dominance
  4. 2005 High

    Extended the LPP interactome and transactivation function, identifying Scrib as a C-terminal partner at cell-cell contacts and confirming LPP LIM domains transactivate within the HMGA2/LPP fusion.

    Evidence Yeast two-hybrid, Co-IP, domain mapping (Scrib); GAL4 and element-specific reporter assays (fusion)

    PMID:15649318 PMID:15755872

    Open questions at the time
    • Functional consequence of LPP-Scrib interaction not established at this stage
    • Endogenous transcriptional targets still unknown
  5. 2006 High

    Identified LPP as a bona fide transcriptional coactivator of ETS factors and dissected its adhesion role, showing it coactivates PEA3/ER81, promotes cell-cell junction assembly via VASP, and is regulated by myocardin/RhoA-ROK in smooth muscle.

    Evidence Co-IP, ChIP on endogenous promoters, reporter assays with knockdown/overexpression; adhesion assays with domain mutants; myocardin overexpression and ROK inhibition with migration assays

    PMID:16397143 PMID:16613855 PMID:16738319

    Open questions at the time
    • Direct ETS target genes not yet defined
    • How nuclear vs adhesion pools are partitioned during signaling unclear
  6. 2008 High

    Connected LPP to noncanonical Wnt/PCP signaling and refined its adhesion mechanism, showing zebrafish Lpp is required for convergence-extension downstream of Wnt11/ROK2 and cooperates with Scrib, and that its alpha-actinin binding site governs cell-contact function.

    Evidence Morpholino knockdown, epistasis with Wnt11/ROK2, Co-IP (zebrafish); domain fragment targeting and fractionation (alpha-actinin)

    PMID:18413140 PMID:18582857

    Open questions at the time
    • Whether PCP role generalizes to mammals not tested
    • Direct transcriptional vs cytoskeletal contribution to C&E not separated
  7. 2010 Medium

    Revealed an unexpected nuclear genome-protective role, showing LPP associates with shelterin (POT1/TRF2/TIN2) at telomeres and is required to prevent telomere dysfunction, with specificity for LPP over zyxin.

    Evidence Yeast two-hybrid, Co-IP with shelterin components, ChIP, siRNA with TIF assay; immunofluorescence at telomeres

    PMID:20634563 PMID:21519191

    Open questions at the time
    • Molecular mechanism of telomere protection by LPP unresolved
    • How LPP is recruited to only a subset of telomeres unknown
  8. 2012 Medium

    Linked LPP-ETS cooperation to cancer invasion, identifying ETV5 as a regulatory partner promoting EMT and invasion and showing TGFbeta induces LPP through ROK in smooth muscle progenitors.

    Evidence Interaction/Co-IP studies and migration/invasion assays (ETV5); ROK inhibition, siRNA, migration assays (SMPC)

    PMID:22266854 PMID:22886954

    Open questions at the time
    • Direct ETV5/LPP target genes not identified at this stage
    • TGFbeta-ROK-LPP link in SMPCs is a single low-confidence study
  9. 2013 High

    Established a mechanistic basis for LPP-driven invasion, showing TGFbeta relocalizes LPP to focal adhesions where its alpha-actinin interaction is required for adhesion turnover, migration, and invasion.

    Evidence siRNA, live-cell FRAP/TIRF imaging of focal adhesion turnover, Co-IP, alpha-actinin-disrupting domain mutants, invasion assays

    PMID:23447672

    Open questions at the time
    • Upstream TGFbeta signal that triggers relocalization not fully defined
    • Relationship between nuclear and adhesion pools during invasion unclear
  10. 2015 High

    Defined a direct transcriptional output of LPP, showing LPP/ETV5 directly drive MMP-15 transcription, with MMP-15 cleaving N-cadherin to restrain collective migration and dissemination.

    Evidence siRNA, MMP-15 promoter reporter, 3D invasion assay, orthotopic mouse model, N-cadherin cleavage Western blot

    PMID:26028032

    Open questions at the time
    • Context-dependent suppressive vs promoting roles of LPP not reconciled
    • Whether MMP-15 is the sole relevant target unknown
  11. 2017 High

    Identified the post-translational and microenvironmental control of LPP-driven metastasis, showing Src phosphorylates LPP at Y245/301/302 to drive invadopodia and metastasis, and that CAF-derived signals upregulate endothelial LPP to control vascular permeability.

    Evidence Phospho-site Y->F mutants, LIM/alpha-actinin domain mutants, intravital chick CAM imaging, mouse metastasis model; CAF/MFAP5-FAK-ERK pathway inhibition, in vivo siRNA, permeability assays

    PMID:28436416 PMID:29251630

    Open questions at the time
    • Direct kinase-substrate stoichiometry and dynamics of Src phosphorylation not resolved
    • How phosphorylation alters LPP partner binding mechanistically unknown
  12. 2023 High

    Established how LPP abundance is controlled, identifying a UBE2S/TRIM21 complex that adds K11-linked polyubiquitin to drive LPP degradation and promote bladder cancer lymphatic metastasis.

    Evidence Co-IP, linkage-specific (K11/K48/K63) ubiquitination assays, siRNA rescue epistasis, in vivo metastasis model, patient organoids

    PMID:37422473

    Open questions at the time
    • Ubiquitination site(s) on LPP not mapped
    • Whether the same axis operates outside bladder cancer untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • How LPP integrates its adhesion-scaffolding, ETS-coactivator, and telomere-protective activities into a single regulated program — and what governs partitioning between these pools — remains unresolved.
  • No structural model of LPP bound to its partners
  • Mechanism coupling adhesion-localized to nuclear function not defined
  • Telomere-protection mechanism uncharacterized

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 4 GO:0008092 cytoskeletal protein binding 3 GO:0060090 molecular adaptor activity 3
Localization
GO:0005634 nucleus 3 GO:0005856 cytoskeleton 2 GO:0005886 plasma membrane 2
Pathway
R-HSA-162582 Signal Transduction 3 R-HSA-1643685 Disease 3 R-HSA-74160 Gene expression (Transcription) 2 R-HSA-392499 Metabolism of proteins 1
Partners
ACTN1ETV5POT1SCRIBTIN2TRF2TRIM21VASP
Complex memberships
shelterin

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 LPP encodes a proline-rich protein with a leucine-zipper motif at its N-terminus and three LIM domains at its C-terminus, classifying it as a novel member of the group 3 LIM protein family. It was identified as the chromosome 3q27-28 translocation partner of HMGIC in lipomas, generating HMGIC/LPP fusion transcripts encoding predicted HMGI-C/LPP fusion proteins. 3'-RACE, CASH, FISH, Northern blot, cDNA cloning, nucleotide sequence analysis, RT-PCR Genomics High 8812423
2000 LPP protein localizes to focal adhesions and cell-to-cell contacts, binds VASP (a protein implicated in actin organization control), accumulates in the nucleus upon CRM1 inhibition by leptomycin B, and contains an N-terminal leucine-rich nuclear export signal. LPP also displays transcriptional activation capacity in GAL4-based assays. Immunofluorescence localization, co-immunoprecipitation (LPP-VASP binding), leptomycin B treatment, GAL4-luciferase transcriptional assay, NES sequence analysis Molecular biology of the cell High 10637295
2002 The LIM domains of LPP are the primary focal adhesion targeting elements, with the linker between LIM domains 1 and 2 playing a pivotal role. The proline-rich region (harboring α-actinin and VASP binding sites) has weak focal adhesion targeting capacity. Overexpressed LIM domains can deplete endogenous LPP and vinculin from focal adhesions. The LPP LIM domains are dispensable for nuclear targeting. Domain deletion/mutation constructs with immunofluorescence localization, overexpression in cultured cells The Journal of biological chemistry High 12441356
2003 LPP is selectively and highly expressed in vascular and visceral smooth muscle. In freshly isolated smooth muscle cells, LPP forms linear arrays at the plasma membrane colocalizing with vinculin at peripheral dense bodies. In cultured smooth muscle cells, LPP co-localizes with vinculin at focal adhesions. Overexpression of LPP increases EGF-stimulated migration of vascular smooth muscle cells. Rho-kinase inhibitor Y-27632 dissociates LPP from focal adhesions and enhances nuclear accumulation of LPP induced by leptomycin B. Western blot, immunofluorescence microscopy, Transwell migration assay, Rho-kinase inhibitor treatment, leptomycin B treatment American journal of physiology. Cell physiology Medium 12760907
2005 LPP interacts with the tumor suppressor protein Scrib (a component of cell-cell contacts). The interaction is mediated by the PDZ domains of Scrib and the C-terminus of LPP. Both proteins co-localize at cell-cell contacts. Scrib is dispensable for targeting LPP to focal adhesions or cell-cell contacts, and LPP is not required for Scrib localization at cell-cell contacts. Yeast two-hybrid, co-immunoprecipitation, immunofluorescence co-localization, domain deletion constructs BMC cell biology High 15649318
2005 The HMGA2/LPP fusion protein retains the transactivation functions of the LPP LIM domains and functions as a transcription factor, activating transcription from the PRDII element of the IFN-β enhancer and the BAT-1 element of the rhodopsin promoter. Wild-type HMGA2 augments the transactivation functions of HMGA2/LPP when co-expressed. GAL4-based luciferase reporter assay, PRDII and BAT-1 element reporter assays, co-transfection/co-expression experiments Molecular cancer research : MCR Medium 15755872
2006 LPP acts as a transcriptional coactivator for the ETS domain transcription factor PEA3. LPP forms a complex with PEA3, is found associated with PEA3-regulated promoters by ChIP, and upregulates PEA3 transactivation capacity when LPP levels are manipulated. LPP also functionally interacts with the related ETS family member ER81. Co-immunoprecipitation, ChIP assay, luciferase reporter assay, siRNA knockdown and overexpression of LPP Molecular and cellular biology High 16738319
2006 The VASP-binding ActA repeat region of LPP (and zyxin) promotes early cell-cell junction assembly. The LIM domain region of LPP acts as a regulatory domain that inhibits this function. Perturbation of LPP function reduces VASP levels in detergent-insoluble cadherin-actin networks and allows accumulation of capping protein at cell-cell contacts. Quantitative cell-cell adhesion assay, domain deletion constructs, dominant-negative mutants, detergent fractionation, immunofluorescence The Journal of biological chemistry Medium 16613855
2006 LPP expression in smooth muscle cells is regulated by myocardin and the RhoA/Rho-kinase (ROK) pathway in a differentiation-dependent manner. All-trans retinoic acid increases LPP expression in a ROK-dependent manner. siRNA silencing of LPP significantly decreases smooth muscle cell migration. LPP expression is rescued and enhances cell spreading in FAK-null fibroblasts by inducible FAK expression. Adenovirus-mediated myocardin overexpression, Rho-kinase inhibitors, siRNA knockdown, FAK-null fibroblast system with inducible FAK re-expression, migration assay Circulation research Medium 16397143
2008 In zebrafish, Lpp is required for convergence and extension (C&E) movements during gastrulation. Morpholino knockdown of lpp phenocopies noncanonical Wnt signaling mutants. Lpp expression is dependent on Wnt11 signaling and downstream Rho kinase 2. Lpp interacts with the PCP protein Scrib in zebrafish, and Lpp and Scrib cooperate to mediate C&E movements. Morpholino knockdown, time-lapse analysis, co-immunoprecipitation (Lpp-Scrib interaction in zebrafish), Wnt11 morphants, dominant-negative Rho kinase 2 overexpression Developmental biology High 18582857
2008 The α-actinin binding site of LPP is required for LPP localization and function at cell-cell contacts; perturbation of LPP (but not zyxin) function reduces anchoring of α-actinin to detergent-insoluble networks at cell-cell contacts. In contrast, zyxin localization and function at cell-cell contacts is independent of its α-actinin binding site. Domain fragment targeting assays, detergent fractionation, immunofluorescence, dominant-negative constructs Biochemical and biophysical research communications Medium 18413140
2009 LPP expression is regulated by mechanical cues and substrate composition in smooth muscle cells: denatured collagen or rigid substrate upregulates LPP, while atheroprone shear stress (applied via an EC/SMC hemodynamic flow system) decreases LPP expression. LPP and its partner palladin are also regulated by oxidative stress and are altered in arterial injury and early atherogenesis models. Smooth muscle cell culture on modified substrates, EC/SMC hemodynamic flow system, ApoE murine atherosclerosis model, arterial injury model, Western blot, immunofluorescence Journal of muscle research and cell motility Medium 19205907
2010 LPP (and TRIP6) associates with the shelterin complex at telomeres and is required for telomere protection. LPP depletion by siRNA leads to induction of telomere dysfunction-induced foci (TIFs). LPP was detected at telomeres by ChIP and co-immunoprecipitated with POT1, TRF2, and TIN2. Yeast two-hybrid screen, co-immunoprecipitation with POT1/TRF2/TIN2, ChIP, siRNA knockdown with TIF assay Aging Medium 20634563
2011 TRIP6 and LPP (but not Zyxin) are detected at a subset of telomeres by immunofluorescence, confirming specificity within the zyxin family for telomere association. Zyxin was not detected at telomeres and was not found in a complex with shelterin, despite high sequence similarity to LPP. Immunofluorescence at telomeres, co-immunoprecipitation to test shelterin association Cell cycle (Georgetown, Tex.) Medium 21519191
2012 ETV5 (an ETS transcription factor) cooperates with LPP as a regulatory partner, with LPP acting as a sensor of extracellular signals promoting tumor invasion. LPP is identified as a regulatory partner of ETV5 in endometrial carcinoma cells, and together they promote epithelial-to-mesenchymal transition (EMT) and invasive capability. Molecular profiling, co-immunoprecipitation/interaction studies, overexpression and knockdown functional assays for migration/invasion Oncogene Medium 22266854
2012 TGF-β1 increases LPP expression in smooth muscle progenitor cells (SMPCs) through a Rho kinase (ROK)-dependent mechanism. ROK inhibition suppresses LPP mRNA expression in TGF-β1-treated SMPCs. siRNA silencing of LPP significantly decreases SMPC migration. ROK inhibitors, siRNA knockdown, RT-PCR, migration assay Journal of Huazhong University of Science and Technology. Medical sciences Low 22886954
2013 LPP is an indispensable regulator of TGFβ-induced migration and invasion in ErbB2-expressing breast cancer cells. Upon TGFβ stimulation, LPP re-localizes to focal adhesion complexes and is a critical determinant of TGFβ-mediated focal adhesion turnover. The interaction between LPP and α-actinin is necessary for TGFβ-induced migration and invasion. siRNA knockdown, live-cell imaging of focal adhesion turnover (TIRF/FRAP), co-immunoprecipitation, domain mutants disrupting LPP-α-actinin interaction, migration/invasion assays Journal of cell science High 23447672
2015 LPP, together with its functional partner ETV5, directly regulates transcription of MMP-15. MMP-15 directly cleaves the N-cadherin extracellular domain, and loss of LPP increases N-cadherin-dependent collective cell migration in lung cancer cells. LPP knockdown promotes cancer cell dissemination in orthotopic mouse models. siRNA knockdown, luciferase reporter assay (MMP-15 promoter), 3D collagen gel invasion assay, orthotopic mouse model, immunohistochemistry, Western blot for N-cadherin cleavage Oncogene High 26028032
2017 LPP localizes to invadopodia (along with Tks5/actin) at sites of matrix degradation and at the tips of extravasating breast cancer cells. Invadopodia formation, cancer cell extravasation, and metastasis require an intact LPP LIM domain and LPP's ability to interact with α-actinin. Src-mediated LPP phosphorylation at tyrosine residues Y245/301/302 is critical for invadopodia formation, breast cancer cell invasion, and metastasis. siRNA knockdown, domain mutants (LIM domain, α-actinin binding site), LPP phospho-site mutants (Y→F), intravital imaging of chick CAM, Src kinase assays, in vitro invasion assays, mouse lung metastasis model Nature communications High 28436416
2017 Cancer-associated fibroblasts (CAFs) upregulate LPP in microvascular endothelial cells (MECs) via a calcium-dependent signaling pathway involving MFAP5, FAK, ERK, and LPP. LPP promotes focal adhesion and stress fiber formation, increases endothelial cell motility and permeability. siRNA-mediated LPP silencing in tumor-bearing mice decreases intratumoral microvessel leakiness and improves chemotherapy delivery. siRNA knockdown in vivo and in vitro, pathway inhibition (FAK, ERK inhibitors), focal adhesion/stress fiber assays, permeability assay, mouse tumor model The Journal of clinical investigation High 29251630
2023 UBE2S interacts with TRIM21 and together they induce K11-linked polyubiquitination (not K48- or K63-linked) of LPP, promoting LPP degradation and bladder cancer lymphatic metastasis. LPP silencing rescues anti-metastatic phenotypes after UBE2S knockdown, placing LPP downstream of the UBE2S/TRIM21 ubiquitination axis. Co-immunoprecipitation, ubiquitination assay with linkage-specific antibodies (K11/K48/K63), siRNA knockdown, in vivo lymphatic metastasis model, human bladder cancer organoids Cell death & disease High 37422473

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein. Genes & development 197 25030700
1996 LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics 170 8812423
2000 LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity. Molecular biology of the cell 132 10637295
1998 TolB protein of Escherichia coli K-12 interacts with the outer membrane peptidoglycan-associated proteins Pal, Lpp and OmpA. Molecular microbiology 129 9701827
2017 Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance. The Journal of clinical investigation 120 29251630
1985 Up-promoter mutations in the lpp gene of Escherichia coli. Nucleic acids research 119 3923441
2011 The free and bound forms of Lpp occupy distinct subcellular locations in Escherichia coli. Molecular microbiology 113 21219470
2020 Lipoprotein Lpp regulates the mechanical properties of the E. coli cell envelope. Nature communications 105 32286264
2018 Lpp, the Braun lipoprotein, turns 50-major achievements and remaining issues. FEMS microbiology letters 89 30107563
1996 Display of beta-lactamase on the Escherichia coli surface: outer membrane phenotypes conferred by Lpp'-OmpA'-beta-lactamase fusions. Protein engineering 89 9005446
2017 LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis. Nature communications 68 28436416
2020 Long non-coding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop. Journal of experimental & clinical cancer research : CR 67 32962742
2002 The focal adhesion and nuclear targeting capacity of the LIM-containing lipoma-preferred partner (LPP) protein. The Journal of biological chemistry 67 12441356
2008 Braun lipoprotein (Lpp) contributes to virulence of yersiniae: potential role of Lpp in inducing bubonic and pneumonic plague. Infection and immunity 63 18227160
2008 Extracellular recombinant protein production from an Escherichia coli lpp deletion mutant. Biotechnology and bioengineering 62 18781683
1992 Poly(A) RNA in Escherichia coli: nucleotide sequence at the junction of the lpp transcript and the polyadenylate moiety. Proceedings of the National Academy of Sciences of the United States of America 61 1380161
1996 Characterization of Escherichia coli expressing an Lpp'OmpA(46-159)-PhoA fusion protein localized in the outer membrane. Applied microbiology and biotechnology 59 8920186
2005 The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus. BMC cell biology 58 15649318
1982 Use of a lac promoter-operator fragment as a transcriptional control switch for expression of the constitutive lpp gene in Escherichia coli. Journal of molecular and applied genetics 58 6286829
2012 The large universal Pantoea plasmid LPP-1 plays a major role in biological and ecological diversification. BMC genomics 53 23151240
2006 The LIM domain protein LPP is a coactivator for the ETS domain transcription factor PEA3. Molecular and cellular biology 53 16738319
2011 Outer membrane lipoprotein Lpp is Gram-negative bacterial cell surface receptor for cationic antimicrobial peptides. The Journal of biological chemistry 51 22084237
2009 Cell Adhesion and Transcriptional Activity - Defining the Role of the Novel Protooncogene LPP. Translational oncology 51 19701494
2023 UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer. Cell death & disease 48 37422473
1998 Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma. Cancer genetics and cytogenetics 47 9772904
1993 OmpF-Lpp signal sequence mutants with varying charge hydrophobicity ratios provide evidence for a phosphatidylglycerol-signal sequence interaction during protein translocation across the Escherichia coli inner membrane. The Journal of biological chemistry 46 8349595
2012 ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas. Oncogene 45 22266854
2009 The CsgA and Lpp proteins of an Escherichia coli O157:H7 strain affect HEp-2 cell invasion, motility, and biofilm formation. Infection and immunity 45 19179421
2006 Opposing roles of zyxin/LPP ACTA repeats and the LIM domain region in cell-cell adhesion. The Journal of biological chemistry 44 16613855
2015 LPP inhibits collective cell migration during lung cancer dissemination. Oncogene 43 26028032
2007 lpp deletion as a permeabilization method. Biotechnology and bioengineering 43 17304571
2001 Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23). Genes, chromosomes & cancer 41 11433529
2000 An identical HMGIC-LPP fusion transcript is consistently expressed in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15). Genes, chromosomes & cancer 39 11066083
2013 A complex containing LPP and α-actinin mediates TGFβ-induced migration and invasion of ErbB2-expressing breast cancer cells. Journal of cell science 38 23447672
2003 LPP, a LIM protein highly expressed in smooth muscle. American journal of physiology. Cell physiology 38 12760907
2006 LPP expression during in vitro smooth muscle differentiation and stent-induced vascular injury. Circulation research 35 16397143
2000 Highly efficient selection of phage antibodies mediated by display of antigen as Lpp-OmpA' fusions on live bacteria. Journal of molecular biology 31 10966794
1998 The t(3;12)(q27;q14-q15) with underlying HMGIC-LPP fusion is not determining an adipocytic phenotype. Genes, chromosomes & cancer 31 9598796
2013 Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant. Human molecular genetics 29 24334606
1970 LPP-1 infection of the blue-green alga Plectonema boryanum. I. Electron microscopy. Journal of virology 29 4992998
2021 Cleavage of Braun's lipoprotein Lpp from the bacterial peptidoglycan by a paralog of l,d-transpeptidases, LdtF. Proceedings of the National Academy of Sciences of the United States of America 28 33941679
2009 Deletion of Braun lipoprotein gene (lpp) and curing of plasmid pPCP1 dramatically alter the virulence of Yersinia pestis CO92 in a mouse model of pneumonic plague. Microbiology (Reading, England) 26 19589835
1964 BLUE-GREEN ALGAL VIRUS LPP-1: PURIFICATION AND PARTIAL CHARACTERIZATION. Science (New York, N.Y.) 25 14148431
2017 Emerging roles for LPP in metastatic cancer progression. Journal of cell communication and signaling 24 29027626
2010 LIM-domain proteins TRIP6 and LPP associate with shelterin to mediate telomere protection. Aging 24 20634563
2016 Quantitative measurement of the outer membrane permeability in Escherichia coli lpp and tol-pal mutants defines the significance of Tol-Pal function for maintaining drug resistance. The Journal of antibiotics 23 27168313
2009 Mechanical properties of the extracellular matrix alter expression of smooth muscle protein LPP and its partner palladin; relationship to early atherosclerosis and vascular injury. Journal of muscle research and cell motility 22 19205907
2008 Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation. Developmental biology 22 18582857
1967 Some biological and physicochemical properties of blue-green algal virus LPP-1. Virology 21 18614060
2005 Transactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2. Molecular cancer research : MCR 20 15755872
1987 Distribution of newly synthesized lipoprotein over the outer membrane and the peptidoglycan sacculus of an Escherichia coli lac-lpp strain. Journal of bacteriology 20 3316185
2021 Lpp positions peptidoglycan at the AcrA-TolC interface in the AcrAB-TolC multidrug efflux pump. Biophysical journal 19 34411576
2017 Designing novel construction for cell surface display of protein E on Escherichia coli using non-classical pathway based on Lpp-OmpA. AMB Express 19 28247289
2016 Protective Immunity Elicited by Oral Immunization of Mice with Salmonella enterica Serovar Typhimurium Braun Lipoprotein (Lpp) and Acetyltransferase (MsbB) Mutants. Frontiers in cellular and infection microbiology 19 27891321
2005 Expression patterns of the LPP-HMGA2 fusion transcript in pulmonary chondroid hamartomas with t(3;12)(q27 approximately 28;q14 approximately 15). Cancer genetics and cytogenetics 19 16271958
2005 Overexpression of HMGA2-LPP fusion transcripts promotes expression of the alpha 2 type XI collagen gene. Biochemical and biophysical research communications 19 16375854
2022 Lpp of Escherichia coli K1 inhibits host ROS production to counteract neutrophil-mediated elimination. Redox biology 18 36592568
2014 Comparison of the organophosphorus hydrolase surface display using InaVN and Lpp-OmpA systems in Escherichia coli. Journal of microbiology and biotechnology 18 24150492
2004 Kinetics and thermodynamics of the unfolding and refolding of the three-stranded alpha-helical coiled coil, Lpp-56. Biochemistry 18 15554696
2017 Epigenetic silencing of LPP/miR-28 in multiple myeloma. Journal of clinical pathology 17 28775176
1970 LPP-1 infection of the blue-green alga Plectonema boryanum. 3. Protein synthesis. Journal of virology 17 4993000
2009 Deletion of Braun lipoprotein gene (lpp) attenuates Yersinia pestis KIM/D27 strain: role of Lpp in modulating host immune response, NF-kappaB activation and cell death. Microbial pathogenesis 16 19737605
2007 Diet with LPP for renal patients increases daily energy expenditure and improves motor function in parkinsonian patients with motor fluctuations. Nutritional neuroscience 16 18019394
1970 LPP-1 infection of the blue-green alga Plectonema boryanum. II. Viral deoxyribonucleic acid synthesis and host deoxyribonucleic acid breakdown. Journal of virology 16 4992999
2014 Surface display expression of Bacillus licheniformis lipase in Escherichia coli using Lpp'OmpA chimera. Journal of microbiology (Seoul, Korea) 15 25163839
2002 Core side-chain packing and backbone conformation in Lpp-56 coiled-coil mutants. Journal of molecular biology 15 12054830
1984 Studies on the modification and processing of prolipoprotein in Escherichia coli. Effects of structural alterations in prolipoprotein on its maturation in wild type and lpp mutants. The Journal of biological chemistry 15 6373750
2010 Fusion of HMGA1 to the LPP/TPRG1 intergenic region in a lipoma identified by mapping paraffin-embedded tissues. Cancer genetics and cytogenetics 14 19963137
2006 Intrapatellar tendon lipoma with chondro-osseous differentiation: detection of HMGA2-LPP fusion gene transcript. Journal of clinical pathology 14 16567472
2022 Fibroblast-derived LPP as a biomarker for treatment response and therapeutic target in gastric cancer. Molecular therapy oncolytics 13 35229032
1976 Immunogenetic polymorphism of lipoproteins in swine. 1. Four additional serum beta-lipoprotein allotypes (Lpp2, Lpp4, Lpp5 and Lpp15) in the Lpp system. Animal blood groups and biochemical genetics 13 188357
1975 Photoreactivation of UV-irradiated blue-green algae and algal virus LPP-1. Archives of microbiology 11 807175
2019 Direct Evidence of an Enzyme-Generated LPP Intermediate in (+)-Limonene Synthase Using a Fluorinated GPP Substrate Analog. ACS chemical biology 10 31433159
2009 Expression of HMGA2-LPP and LPP-HMGA2 fusion genes in lipoma: identification of a novel type of LPP-HMGA2 transcript in four cases. Anticancer research 10 19528502
2008 Electrostatic contribution to the thermodynamic and kinetic stability of the homotrimeric coiled coil Lpp-56: A computational study. Proteins 10 17729276
2008 alpha-Actinin links LPP, but not zyxin, to cadherin-based junctions. Biochemical and biophysical research communications 10 18413140
2022 A Defect in Lipoprotein Modification by Lgt Leads to Abnormal Morphology and Cell Death in Escherichia coli That Is Independent of Major Lipoprotein Lpp. Journal of bacteriology 9 35938851
2020 Molecular dynamics simulation and experimental study of the surface-display of SPA protein via Lpp-OmpA system for screening of IgG. AMB Express 9 32880759
2019 Single nucleotide polymorphism in the 3' untranslated region of LPP is a risk factor for lung cancer: a case-control study. BMC cancer 9 30621612
2017 Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis. International journal of environmental research and public health 9 28208589
2006 Stability and folding/unfolding kinetics of the homotrimeric coiled coil Lpp-56. Biochemistry 9 16846236
1967 Physical properties of the DNA from the blue-green algal virus LPP-1. Virology 9 18614061
2023 Sequencing the genomes of LPP-1, the first isolated cyanophage, and its relative LPP-2 reveal different integration mechanisms in closely related phages. Harmful algae 8 37164560
2011 TRIP6 and LPP, but not Zyxin, are present at a subset of telomeres in human cells. Cell cycle (Georgetown, Tex.) 8 21519191
2006 MRI characteristics of parosteal lipomas associated with the HMGA2-LPP fusion gene. Anticancer research 8 16821597
1985 Evolution of the lipoprotein gene in the enterobacteriaceae. Cloning and DNA sequence of the lpp gene from Proteus mirabilis. Journal of molecular biology 8 3903165
2022 Circular RNA circLRCH3 Inhibits Proliferation, Migration, and Invasion of Colorectal Cancer Cells Through miRNA-223/LPP Axis. OncoTargets and therapy 7 35611368
2021 Membrane Stress Caused by Unprocessed Outer Membrane Lipoprotein Intermediate Pro-Lpp Affects DnaA and Fis-Dependent Growth. Frontiers in microbiology 6 34163454
2019 Does facial action modulate neural responses of emotion? An examination with the late positive potential (LPP). Emotion (Washington, D.C.) 6 31815498
2012 Association study of gene LPP in women with polycystic ovary syndrome. PloS one 6 23056290
2001 A novel LPP fusion gene indicates the crucial role of truncated LPP proteins in lipomas and pulmonary chondroid hamartomas. Cytogenetics and cell genetics 6 12063392
2002 Expression of the HMGA2-LPP fusion transcript in only 1 of 61 karyotypically normal pulmonary chondroid hamartomas. Cancer genetics and cytogenetics 5 12505264
2012 TGF-β1-induced LPP expression dependant on Rho kinase during differentiation and migration of bone marrow-derived smooth muscle progenitor cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 4 22886954
2023 When less is more: shortening the Lpp protein leads to increased vancomycin resistance in Escherichia coli. The Journal of antibiotics 3 37749219
2022 LPP polymorphisms are risk factors for allergic rhinitis in the Chinese Han population. Cytokine 3 36084606
2019 3'UTR SNPs in the LPP gene associated with Immunoglobulin A nephropathy risk in the Chinese Han population. International immunopharmacology 3 31295688
2019 Attentional Processing of Facial Expressions and Gaze Direction in Depression and First-Episode Psychosis as Reflected by LPP Modulation. Clinical neuropsychiatry 3 34908933
2025 Lipoprotein Lpp and L, D-transpeptidases regulate the master regulator of virulence AggR in EAEC. Scientific reports 2 40263412
2024 Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease in Subjects from Punjab, Pakistan. Genes 2 39062631
2023 Long Non-Coding RNA LPP-AS2 Plays an Anti-Tumor Role in Thyroid Carcinoma by Regulating the miR-132-3p/OLFM1 Axis. Critical reviews in eukaryotic gene expression 2 37199315

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