Affinage

LPP

Lipoma-preferred partner · UniProt Q93052

Length
612 aa
Mass
65.7 kDa
Annotated
2026-04-28
100 papers in source corpus 21 papers cited in narrative 21 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

LPP is a zyxin-family LIM domain protein that functions as a dual-compartment signaling hub, integrating cytoskeletal dynamics at focal adhesions and cell-cell contacts with transcriptional regulation in the nucleus. At adhesion sites, LPP is targeted by its three C-terminal LIM domains, where it recruits VASP via N-terminal FPPPPP motifs and binds alpha-actinin to regulate actin organization, focal adhesion turnover, and cell migration; these interactions are essential for TGFβ-induced invasion, invadopodia formation driven by Src phosphorylation at Y245/Y301/Y302, and early cell-cell junction assembly (PMID:10637295, PMID:12441356, PMID:28436416, PMID:16613855, PMID:23447672). LPP undergoes CRM1-dependent nucleocytoplasmic shuttling regulated by Rho-kinase, and in the nucleus it serves as a transcriptional coactivator for PEA3/ETV5 family ETS factors to drive expression of target genes such as MMP-15, linking adhesion-derived signals to gene programs controlling EMT and invasion (PMID:16738319, PMID:26028032, PMID:22266854). LPP protein stability is controlled by UBE2S/TRIM21-mediated K11-linked polyubiquitination, and LPP also associates with shelterin components at telomeres where it suppresses telomere dysfunction-induced DNA damage signaling (PMID:37422473, PMID:20634563).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1996 High

    The identity and domain architecture of LPP were established, revealing it as a novel LIM-domain protein and the preferred translocation partner of HMGIC in lipomas, thus framing the gene as relevant to mesenchymal tumorigenesis.

    Evidence 3'-RACE, FISH, cDNA cloning from lipoma translocation breakpoints

    PMID:8812423

    Open questions at the time
    • No functional data on LPP protein activity
    • No subcellular localization determined
    • Role of individual domains unknown
  2. 2000 High

    LPP was shown to be a nucleocytoplasmic shuttling protein that localizes to focal adhesions and cell-cell contacts, binds VASP, possesses a CRM1-dependent nuclear export signal, and has intrinsic transcriptional activation capacity — establishing its dual-compartment biology.

    Evidence Immunofluorescence, co-immunoprecipitation, leptomycin B treatment, GAL4-luciferase reporter assay in mammalian cells

    PMID:10637295

    Open questions at the time
    • Mechanism of nuclear function unknown
    • Whether shuttling is regulated by signaling pathways not addressed
    • Identity of transcriptional targets unknown
  3. 2002 High

    Systematic domain dissection resolved that the three LIM domains cooperatively target LPP to focal adhesions (with the LIM1-LIM2 linker being critical), while the pre-LIM proline-rich region mediates weaker adhesion targeting through alpha-actinin and VASP binding, clarifying the modular logic of LPP localization.

    Evidence Deletion/mutation constructs with fluorescence microscopy, dominant-negative displacement of endogenous LPP from focal adhesions

    PMID:12441356

    Open questions at the time
    • Structural basis of LIM domain targeting not resolved
    • Whether LIM domains mediate protein-protein interactions at adhesions or lipid binding unknown
  4. 2003 High

    LPP was found to be highly expressed in vascular smooth muscle cells and to promote EGF-stimulated SMC migration, with Rho-kinase activity controlling both focal adhesion retention and nuclear accumulation of LPP, placing LPP under RhoA/ROCK signaling control.

    Evidence Immunofluorescence, Transwell migration, Y-27632 and leptomycin B pharmacological treatments in SMCs

    PMID:12760907

    Open questions at the time
    • Direct phosphorylation by Rho-kinase not shown
    • Whether nuclear LPP contributes to migration phenotype unclear
  5. 2005 High

    Identification of Scrib as a direct binding partner of LPP at cell-cell contacts, mediated by Scrib PDZ domains and the LPP C-terminus, provided a molecular link between LPP and the polarity/tumor suppressor machinery.

    Evidence Yeast two-hybrid, reciprocal co-immunoprecipitation, immunofluorescence co-localization, domain deletion mapping

    PMID:15649318

    Open questions at the time
    • Functional consequence of LPP-Scrib interaction on polarity or proliferation not tested
    • Whether Scrib regulates LPP shuttling unknown
  6. 2006 High

    Multiple studies converged to define LPP's transcriptional and adhesion functions: LPP was identified as a coactivator of PEA3/ER81 ETS transcription factors on endogenous promoters, shown to promote early cell-cell junction assembly through its VASP-binding repeats with LIM domains acting as an auto-inhibitory module, and placed downstream of FAK and myocardin/Rho-kinase signaling for SMC migration.

    Evidence ChIP on PEA3-regulated promoters, co-immunoprecipitation, luciferase reporters, quantitative adhesion assays with dominant-negative constructs, siRNA in SMCs, FAK-null cell reconstitution

    PMID:16397143 PMID:16613855 PMID:16738319

    Open questions at the time
    • Direct transcriptional target genes of LPP/PEA3 not comprehensively identified
    • Structural basis of LIM domain auto-inhibition of VASP-mediated adhesion not resolved
  7. 2008 High

    In vivo genetic evidence from zebrafish established that LPP functions in non-canonical Wnt/PCP signaling during gastrulation convergence and extension, acting downstream of Wnt11 and Rho-kinase 2 in cooperation with Scrib, extending LPP's roles beyond adhesion/migration to developmental morphogenesis. Separately, alpha-actinin was shown to specifically link LPP (not zyxin) to cadherin-based junctions.

    Evidence Morpholino knockdown with epistasis analysis and time-lapse imaging in zebrafish; domain targeting and detergent fractionation in mammalian cells

    PMID:18413140 PMID:18582857

    Open questions at the time
    • Whether Wnt/PCP role is conserved in mammalian development not tested
    • Direct molecular mechanism by which LPP affects PCP downstream of Scrib unknown
  8. 2010 High

    The unexpected finding that LPP associates with shelterin components (POT1, TRF2, TIN2) at telomeres and is required to suppress telomere dysfunction-induced foci revealed a chromatin-associated protective function distinct from adhesion or transcription.

    Evidence Yeast two-hybrid, co-immunoprecipitation with multiple shelterin proteins, ChIP at telomeres, siRNA depletion causing TIF formation in human cells

    PMID:20634563

    Open questions at the time
    • Which LPP domain mediates shelterin interaction unknown
    • Whether telomere function requires LPP shuttling or is constitutively nuclear unclear
    • Mechanism by which LPP suppresses DNA damage response at telomeres not defined
  9. 2013 High

    LPP was shown to be indispensable for TGFβ-induced migration and invasion in ErbB2-positive breast cancer cells by mediating focal adhesion turnover through its alpha-actinin interaction, mechanistically linking LPP to oncogenic signal-dependent invasion programs.

    Evidence siRNA knockdown, live-cell focal adhesion dynamics imaging, co-immunoprecipitation, Transwell invasion assays in breast cancer cells

    PMID:23447672

    Open questions at the time
    • How TGFβ signaling triggers LPP relocalization to focal adhesions not defined
    • Whether nuclear LPP/transcriptional activity contributes to invasion phenotype not separated
  10. 2015 High

    A complete transcriptional pathway was delineated: LPP cooperates with ETV5 to directly activate MMP-15 transcription, MMP-15 cleaves N-cadherin, and loss of LPP paradoxically increases N-cadherin-dependent collective cell migration and in vivo lung cancer dissemination, revealing context-dependent pro- and anti-migratory roles.

    Evidence siRNA, MMP-15 promoter reporter, 3D collagen invasion, orthotopic mouse model with lung cancer cells

    PMID:26028032

    Open questions at the time
    • Full repertoire of LPP/ETV5 target genes unknown
    • Whether this pathway operates in non-cancer contexts not addressed
  11. 2017 High

    Src-mediated phosphorylation of LPP at Y245/Y301/Y302 was identified as the critical switch for invadopodia formation and metastasis, with LPP localizing to invadopodia alongside Tks5; separately, a MFAP5→FAK→ERK→LPP axis in endothelial cells was shown to regulate tumor vascular permeability, broadening LPP's role to the tumor microenvironment.

    Evidence Phospho-site mutagenesis, intravital imaging in CAM model, mouse lung metastasis assay; in vivo siRNA delivery in tumor-bearing mice with permeability measurements

    PMID:28436416 PMID:29251630

    Open questions at the time
    • Whether Src phosphorylation affects LPP nuclear functions or transcriptional activity untested
    • Downstream effectors recruited by phospho-LPP at invadopodia unknown
    • Structural consequences of Y245/Y301/Y302 phosphorylation unresolved
  12. 2023 High

    The mechanism controlling LPP protein turnover was defined: UBE2S cooperates with TRIM21 E3 ligase to catalyze K11-linked polyubiquitination of LPP, targeting it for degradation, and LPP acts as the critical downstream effector of UBE2S in promoting EMT and lymphatic metastasis in bladder cancer.

    Evidence Co-immunoprecipitation, ubiquitination assays with linkage-specific ubiquitin mutants, epistatic siRNA rescue, in vivo lymphatic metastasis model

    PMID:37422473

    Open questions at the time
    • Specific lysine residues on LPP targeted for K11-ubiquitination not mapped
    • Whether TRIM21-mediated degradation is signal-regulated not determined
    • Relationship between ubiquitin-mediated turnover and phosphorylation-dependent functions unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How the nuclear and cytoplasmic pools of LPP are coordinately regulated — and whether post-translational modifications such as Src phosphorylation or K11-ubiquitination differentially affect adhesion versus transcriptional functions — remains unresolved.
  • No structural model of LPP or its LIM domain-mediated interactions exists
  • Comprehensive identification of LPP/ETV5 transcriptional targets genome-wide has not been performed
  • Whether telomere-protective and adhesion/transcription functions are mechanistically linked is unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0008092 cytoskeletal protein binding 5 GO:0140110 transcription regulator activity 5 GO:0060090 molecular adaptor activity 3
Localization
GO:0005856 cytoskeleton 6 GO:0005634 nucleus 4 GO:0005886 plasma membrane 4 GO:0005694 chromosome 2
Pathway
R-HSA-162582 Signal Transduction 5 R-HSA-74160 Gene expression (Transcription) 4 R-HSA-1500931 Cell-Cell communication 3 R-HSA-1474244 Extracellular matrix organization 1 R-HSA-392499 Metabolism of proteins 1
Partners
ACTN1ETV5PEA3POT1SCRIBTRF2TRIM21VASP
Complex memberships
shelterin-associated complex

Evidence

Reading pass · 21 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1996 LPP (lipoma preferred partner) was identified as a novel LIM domain protein with a proline-rich N-terminal region containing a leucine-zipper motif and three LIM domains at its carboxy-terminus, and is the preferred fusion partner of HMGIC in lipomas due to recurrent t(3;12)(q13-15;q27-28) translocations. 3'-RACE analysis, CASH, FISH, Northern blot, cDNA cloning, nucleotide sequence analysis Genomics High 8812423
2000 LPP localizes to focal adhesions and cell-to-cell contacts, binds VASP (a protein involved in actin organization), accumulates in the nucleus upon CRM1 inhibition by leptomycin B, contains a leucine-rich nuclear export signal (NES) in its N-terminal region, and displays transcriptional activation capacity as measured by GAL4-based assays. Immunofluorescence localization, co-immunoprecipitation/binding assays, leptomycin B treatment, GAL4-luciferase reporter assay Molecular biology of the cell High 10637295
2002 The LIM domains of LPP are the primary focal adhesion targeting elements and cooperate to provide robust targeting; the linker between LIM domains 1 and 2 is pivotal for this targeting. The proline-rich pre-LIM region (containing alpha-actinin and VASP binding sites) has weak targeting capacity to focal adhesions and stress fibers. LIM domains are dispensable for nuclear targeting of LPP. Domain deletion/mutation analysis, fluorescence microscopy, overexpression of LIM domain fragments to deplete endogenous LPP and vinculin from focal adhesions The Journal of biological chemistry High 12441356
2005 LPP interacts with the tumor suppressor protein Scrib (human homologue of Drosophila scribble); this interaction is mediated by the PDZ domains of Scrib and the carboxy-terminus of LPP. Both proteins co-localize at cell-cell contacts, linking LPP to Scrib-associated functions and providing a communication pathway between cell-cell contacts and the nucleus. Co-immunoprecipitation, yeast two-hybrid, immunofluorescence co-localization, domain deletion analysis BMC cell biology High 15649318
2006 LPP acts as a transcriptional coactivator for the ETS domain transcription factor PEA3: LPP forms a complex with PEA3, is found associated with PEA3-regulated promoters by ChIP, has intrinsic transactivation capacity, and upregulates PEA3 transactivation. LPP also functionally interacts similarly with related family member ER81. Co-immunoprecipitation, ChIP, luciferase reporter assays, siRNA knockdown/overexpression Molecular and cellular biology High 16738319
2006 Zyxin and LPP promote the rate of early cell-cell junction assembly through their VASP-binding ActA (FPPPPP) repeat region; the LIM domain region acts as a regulatory domain that inhibits this function. Deletion of LIM domains drives adhesion and increases VASP levels in detergent-insoluble cadherin-actin networks. Dominant-negative zyxin/LPP mutants reduce adhesion rate and allow capping protein accumulation at cell-cell contacts. Quantitative cell-cell adhesion assay, dominant-negative constructs, detergent fractionation, immunofluorescence The Journal of biological chemistry High 16613855
2003 LPP is highly and selectively expressed in vascular and visceral smooth muscle cells, colocalizes with vinculin at focal adhesions (peripheral dense bodies) in smooth muscle cells, and overexpression of LPP increases EGF-stimulated migration of vascular smooth muscle cells. Rho-kinase inhibition dissociates focal adhesions/LPP peripheral staining and enhances nuclear accumulation of LPP induced by leptomycin B, indicating a Rho-kinase-sensitive nucleocytoplasmic shuttling mechanism. Immunofluorescence microscopy, Western blot, Transwell migration assay, Y-27632 Rho-kinase inhibitor treatment, leptomycin B treatment American journal of physiology. Cell physiology High 12760907
2006 LPP expression in smooth muscle cells (SMCs) is regulated by myocardin and RhoA/Rho-kinase (ROK) signaling. LPP silencing with siRNA significantly decreases SMC migration. LPP expression is decreased in focal adhesion kinase (FAK)-null cells and rescued by inducible FAK re-expression; LPP expression in FAK-null fibroblasts enhances cell spreading. siRNA knockdown, adenovirus overexpression, FAK-null cell lines, Transwell migration assays, cell spreading assays, RT-PCR Circulation research High 16397143
2008 LPP (zebrafish ortholog) is required for convergence and extension (C&E) movements during gastrulation, acting in the non-canonical Wnt/PCP signaling pathway. Morpholino knockdown of lpp phenocopies Wnt signaling mutants; lpp expression depends on Wnt11 and Rho-kinase 2. LPP interacts with the PCP protein Scrib in zebrafish and cooperates with Scrib for C&E mediation. Morpholino knockdown, time-lapse imaging, epistasis with Wnt11 morphants, dominant-negative Rho-kinase 2 overexpression, co-immunoprecipitation (LPP-Scrib interaction in zebrafish) Developmental biology High 18582857
2010 LPP (and TRIP6) associate with the shelterin telomere protection complex, co-immunoprecipitate with POT1, TRF2, and TIN2 in human cells, are detected at telomeres by ChIP, and are required for repressing the DNA damage response at telomeres (as shown by siRNA-mediated depletion causing telomere dysfunction-induced foci, TIFs). Yeast two-hybrid screen, co-immunoprecipitation, ChIP, siRNA knockdown with immunofluorescence TIF assay Aging High 20634563
2011 LPP and TRIP6 (but not zyxin) are detected at a subset of telomeres in human cells by immunofluorescence, confirming specificity of LIM protein recruitment to telomeres, likely at critically short telomeres. Immunofluorescence at telomeres, comparison across zyxin family members Cell cycle Medium 21519191
2008 Alpha-actinin links LPP (but not zyxin) to cadherin-based cell-cell junctions; the alpha-actinin binding site of LPP is required for LPP localization and function at cell-cell contacts. Perturbation of LPP function (not zyxin) changes anchoring of alpha-actinin to detergent-insoluble networks at cell-cell contacts. Domain fragment targeting assays, detergent fractionation, immunofluorescence, functional adhesion perturbation Biochemical and biophysical research communications Medium 18413140
2013 LPP is an indispensable regulator of TGFβ-induced migration and invasion of ErbB2-expressing breast cancer cells. Upon TGFβ stimulation, LPP re-localizes to focal adhesion complexes and mediates focal adhesion turnover. The interaction between LPP and alpha-actinin is necessary for TGFβ-induced migration and invasion. siRNA knockdown, live-cell imaging of focal adhesion dynamics, co-immunoprecipitation, Transwell invasion/migration assays Journal of cell science High 23447672
2015 LPP, together with its functional partner Etv5, directly transcriptionally activates MMP-15, which in turn degrades the extracellular domain of N-cadherin. Loss of LPP increases N-cadherin-dependent collective cell migration (CCM) in 3D collagen invasion assays and promotes in vivo dissemination of lung cancer cells. siRNA knockdown, 3D collagen invasion assay, orthotopic mouse model, RT-PCR, immunohistochemistry, luciferase reporter (MMP-15 promoter), direct N-cadherin cleavage by MMP-15 Oncogene High 26028032
2017 LPP localizes to invadopodia along with Tks5/actin at sites of matrix degradation and is required for invadopodia formation. LPP is phosphorylated by Src at specific tyrosine residues (Y245/301/302), and this Src-mediated phosphorylation is critical for invadopodia formation, breast cancer cell invasion, and lung metastasis. Invadopodia formation also requires an intact LPP LIM domain and LPP-alpha-actinin interaction. siRNA knockdown, domain/point mutants, intravital imaging (CAM model), Src kinase phosphorylation assay, in vitro invasion assay, mouse lung metastasis model Nature communications High 28436416
2017 CAFs upregulate LPP in microvascular endothelial cells via a calcium-dependent MFAP5→FAK→ERK→LPP signaling pathway. Endothelial LPP increases focal adhesion and stress fiber formation to promote endothelial cell motility and permeability. siRNA-mediated LPP silencing in vivo decreases intratumoral microvessel leakiness and improves paclitaxel delivery to tumor cells. siRNA knockdown, co-culture (CAF/endothelial cells), pathway inhibitor studies, in vivo siRNA treatment in tumor-bearing mice, permeability assays, drug delivery measurement The Journal of clinical investigation High 29251630
2005 The HMGA2/LPP fusion protein retains the transcriptional activation functions of the LPP LIM domains, activates transcription from PRDII and BAT-1 elements, and is augmented by co-expressed wild-type HMGA2. This supports a model where HMGA2/LPP functions as a transcription factor in lipomagenesis. GAL4-based and promoter-based luciferase reporter assays, co-transfection, RT-PCR in lipoma samples Molecular cancer research : MCR Medium 15755872
2012 LPP acts as a regulatory partner of ETV5 transcription factor, sensing extracellular signals to promote epithelial-to-mesenchymal transition (EMT) and tumor invasion in endometrial carcinoma cells. ETV5 modulates Zeb1 and E-cadherin repression, and LPP cooperates with ETV5 to promote migratory and invasive capabilities. Co-immunoprecipitation, siRNA knockdown, reporter assays, invasion/migration assays, molecular profiling Oncogene Medium 22266854
2013 Treatment of control fibroblasts with gliadin peptide P31-43 mimics a celiac disease cellular phenotype, including altered LPP sub-cellular distribution (redistribution away from focal adhesions), altered cell shape, actin organization, and increased focal adhesion number, linking LPP localization changes to celiac disease pathogenesis. Immunofluorescence, cell shape analysis, focal adhesion quantification, peptide treatment of fibroblasts PloS one Medium 24278174
2023 UBE2S interacts with TRIM21 E3 ligase and jointly induces K11-linked polyubiquitination of LPP (not K48- or K63-linked), leading to LPP degradation. LPP silencing rescues the anti-metastatic phenotypes and inhibits EMT caused by UBE2S knockdown in bladder cancer cells, placing LPP downstream of the UBE2S-TRIM21 ubiquitin axis in lymphatic metastasis. Co-immunoprecipitation, ubiquitination assay with K11/K48/K63 mutant ubiquitin, siRNA knockdown, in vivo lymphatic metastasis model, organoid experiments Cell death & disease High 37422473
2009 LPP expression in SMCs is regulated by TGF-β1 in a Rho-kinase (ROK)-dependent manner during differentiation and migration of bone marrow-derived smooth muscle progenitor cells; siRNA silencing of LPP significantly decreases SMC migration. siRNA knockdown, ROK inhibitor treatment, RT-PCR, migration assay Journal of Huazhong University of Science and Technology Medium 22886954

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 MicL, a new σE-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein. Genes & development 197 25030700
1996 LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics 170 8812423
2000 LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity. Molecular biology of the cell 132 10637295
1998 TolB protein of Escherichia coli K-12 interacts with the outer membrane peptidoglycan-associated proteins Pal, Lpp and OmpA. Molecular microbiology 129 9701827
1985 Up-promoter mutations in the lpp gene of Escherichia coli. Nucleic acids research 119 3923441
2017 Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance. The Journal of clinical investigation 118 29251630
2011 The free and bound forms of Lpp occupy distinct subcellular locations in Escherichia coli. Molecular microbiology 113 21219470
2020 Lipoprotein Lpp regulates the mechanical properties of the E. coli cell envelope. Nature communications 101 32286264
2018 Lpp, the Braun lipoprotein, turns 50-major achievements and remaining issues. FEMS microbiology letters 89 30107563
1996 Display of beta-lactamase on the Escherichia coli surface: outer membrane phenotypes conferred by Lpp'-OmpA'-beta-lactamase fusions. Protein engineering 88 9005446
2017 LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis. Nature communications 67 28436416
2002 The focal adhesion and nuclear targeting capacity of the LIM-containing lipoma-preferred partner (LPP) protein. The Journal of biological chemistry 67 12441356
2020 Long non-coding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop. Journal of experimental & clinical cancer research : CR 66 32962742
2008 Braun lipoprotein (Lpp) contributes to virulence of yersiniae: potential role of Lpp in inducing bubonic and pneumonic plague. Infection and immunity 63 18227160
2008 Extracellular recombinant protein production from an Escherichia coli lpp deletion mutant. Biotechnology and bioengineering 62 18781683
1992 Poly(A) RNA in Escherichia coli: nucleotide sequence at the junction of the lpp transcript and the polyadenylate moiety. Proceedings of the National Academy of Sciences of the United States of America 61 1380161
1996 Characterization of Escherichia coli expressing an Lpp'OmpA(46-159)-PhoA fusion protein localized in the outer membrane. Applied microbiology and biotechnology 59 8920186
2005 The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus. BMC cell biology 58 15649318
1982 Use of a lac promoter-operator fragment as a transcriptional control switch for expression of the constitutive lpp gene in Escherichia coli. Journal of molecular and applied genetics 58 6286829
2006 The LIM domain protein LPP is a coactivator for the ETS domain transcription factor PEA3. Molecular and cellular biology 53 16738319
2012 The large universal Pantoea plasmid LPP-1 plays a major role in biological and ecological diversification. BMC genomics 52 23151240
2009 Cell Adhesion and Transcriptional Activity - Defining the Role of the Novel Protooncogene LPP. Translational oncology 51 19701494
2011 Outer membrane lipoprotein Lpp is Gram-negative bacterial cell surface receptor for cationic antimicrobial peptides. The Journal of biological chemistry 50 22084237
1998 Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma. Cancer genetics and cytogenetics 47 9772904
2023 UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer. Cell death & disease 46 37422473
1993 OmpF-Lpp signal sequence mutants with varying charge hydrophobicity ratios provide evidence for a phosphatidylglycerol-signal sequence interaction during protein translocation across the Escherichia coli inner membrane. The Journal of biological chemistry 46 8349595
2009 The CsgA and Lpp proteins of an Escherichia coli O157:H7 strain affect HEp-2 cell invasion, motility, and biofilm formation. Infection and immunity 45 19179421
2012 ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas. Oncogene 44 22266854
2006 Opposing roles of zyxin/LPP ACTA repeats and the LIM domain region in cell-cell adhesion. The Journal of biological chemistry 44 16613855
2007 lpp deletion as a permeabilization method. Biotechnology and bioengineering 43 17304571
2015 LPP inhibits collective cell migration during lung cancer dissemination. Oncogene 42 26028032
2001 Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23). Genes, chromosomes & cancer 41 11433529
2000 An identical HMGIC-LPP fusion transcript is consistently expressed in pulmonary chondroid hamartomas with t(3;12)(q27-28;q14-15). Genes, chromosomes & cancer 39 11066083
2013 A complex containing LPP and α-actinin mediates TGFβ-induced migration and invasion of ErbB2-expressing breast cancer cells. Journal of cell science 38 23447672
2003 LPP, a LIM protein highly expressed in smooth muscle. American journal of physiology. Cell physiology 36 12760907
2006 LPP expression during in vitro smooth muscle differentiation and stent-induced vascular injury. Circulation research 35 16397143
2000 Highly efficient selection of phage antibodies mediated by display of antigen as Lpp-OmpA' fusions on live bacteria. Journal of molecular biology 31 10966794
1998 The t(3;12)(q27;q14-q15) with underlying HMGIC-LPP fusion is not determining an adipocytic phenotype. Genes, chromosomes & cancer 31 9598796
2013 Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant. Human molecular genetics 29 24334606
1970 LPP-1 infection of the blue-green alga Plectonema boryanum. I. Electron microscopy. Journal of virology 29 4992998
2021 Cleavage of Braun's lipoprotein Lpp from the bacterial peptidoglycan by a paralog of l,d-transpeptidases, LdtF. Proceedings of the National Academy of Sciences of the United States of America 27 33941679
2009 Deletion of Braun lipoprotein gene (lpp) and curing of plasmid pPCP1 dramatically alter the virulence of Yersinia pestis CO92 in a mouse model of pneumonic plague. Microbiology (Reading, England) 26 19589835
1964 BLUE-GREEN ALGAL VIRUS LPP-1: PURIFICATION AND PARTIAL CHARACTERIZATION. Science (New York, N.Y.) 25 14148431
2017 Emerging roles for LPP in metastatic cancer progression. Journal of cell communication and signaling 24 29027626
2010 LIM-domain proteins TRIP6 and LPP associate with shelterin to mediate telomere protection. Aging 24 20634563
2009 Mechanical properties of the extracellular matrix alter expression of smooth muscle protein LPP and its partner palladin; relationship to early atherosclerosis and vascular injury. Journal of muscle research and cell motility 22 19205907
2008 Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation. Developmental biology 22 18582857
2016 Quantitative measurement of the outer membrane permeability in Escherichia coli lpp and tol-pal mutants defines the significance of Tol-Pal function for maintaining drug resistance. The Journal of antibiotics 21 27168313
2013 A celiac cellular phenotype, with altered LPP sub-cellular distribution, is inducible in controls by the toxic gliadin peptide P31-43. PloS one 21 24278174
1967 Some biological and physicochemical properties of blue-green algal virus LPP-1. Virology 21 18614060
2005 Transactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2. Molecular cancer research : MCR 20 15755872
1987 Distribution of newly synthesized lipoprotein over the outer membrane and the peptidoglycan sacculus of an Escherichia coli lac-lpp strain. Journal of bacteriology 20 3316185
2016 Protective Immunity Elicited by Oral Immunization of Mice with Salmonella enterica Serovar Typhimurium Braun Lipoprotein (Lpp) and Acetyltransferase (MsbB) Mutants. Frontiers in cellular and infection microbiology 19 27891321
2005 Overexpression of HMGA2-LPP fusion transcripts promotes expression of the alpha 2 type XI collagen gene. Biochemical and biophysical research communications 19 16375854
2021 Lpp positions peptidoglycan at the AcrA-TolC interface in the AcrAB-TolC multidrug efflux pump. Biophysical journal 18 34411576
2014 Comparison of the organophosphorus hydrolase surface display using InaVN and Lpp-OmpA systems in Escherichia coli. Journal of microbiology and biotechnology 18 24150492
2005 Expression patterns of the LPP-HMGA2 fusion transcript in pulmonary chondroid hamartomas with t(3;12)(q27 approximately 28;q14 approximately 15). Cancer genetics and cytogenetics 18 16271958
2004 Kinetics and thermodynamics of the unfolding and refolding of the three-stranded alpha-helical coiled coil, Lpp-56. Biochemistry 18 15554696
2022 Lpp of Escherichia coli K1 inhibits host ROS production to counteract neutrophil-mediated elimination. Redox biology 17 36592568
2017 Designing novel construction for cell surface display of protein E on Escherichia coli using non-classical pathway based on Lpp-OmpA. AMB Express 17 28247289
2017 Epigenetic silencing of LPP/miR-28 in multiple myeloma. Journal of clinical pathology 17 28775176
1970 LPP-1 infection of the blue-green alga Plectonema boryanum. 3. Protein synthesis. Journal of virology 17 4993000
2009 Deletion of Braun lipoprotein gene (lpp) attenuates Yersinia pestis KIM/D27 strain: role of Lpp in modulating host immune response, NF-kappaB activation and cell death. Microbial pathogenesis 16 19737605
2007 Diet with LPP for renal patients increases daily energy expenditure and improves motor function in parkinsonian patients with motor fluctuations. Nutritional neuroscience 16 18019394
1970 LPP-1 infection of the blue-green alga Plectonema boryanum. II. Viral deoxyribonucleic acid synthesis and host deoxyribonucleic acid breakdown. Journal of virology 16 4992999
2014 Surface display expression of Bacillus licheniformis lipase in Escherichia coli using Lpp'OmpA chimera. Journal of microbiology (Seoul, Korea) 15 25163839
2002 Core side-chain packing and backbone conformation in Lpp-56 coiled-coil mutants. Journal of molecular biology 15 12054830
1984 Studies on the modification and processing of prolipoprotein in Escherichia coli. Effects of structural alterations in prolipoprotein on its maturation in wild type and lpp mutants. The Journal of biological chemistry 15 6373750
2010 Fusion of HMGA1 to the LPP/TPRG1 intergenic region in a lipoma identified by mapping paraffin-embedded tissues. Cancer genetics and cytogenetics 14 19963137
2006 Intrapatellar tendon lipoma with chondro-osseous differentiation: detection of HMGA2-LPP fusion gene transcript. Journal of clinical pathology 14 16567472
2022 Fibroblast-derived LPP as a biomarker for treatment response and therapeutic target in gastric cancer. Molecular therapy oncolytics 13 35229032
1976 Immunogenetic polymorphism of lipoproteins in swine. 1. Four additional serum beta-lipoprotein allotypes (Lpp2, Lpp4, Lpp5 and Lpp15) in the Lpp system. Animal blood groups and biochemical genetics 13 188357
2024 Genome-Wide Association Study of Atorvastatin Pharmacokinetics: Associations With SLCO1B1, UGT1A3, and LPP. Clinical pharmacology and therapeutics 11 38493369
1975 Photoreactivation of UV-irradiated blue-green algae and algal virus LPP-1. Archives of microbiology 11 807175
2019 Direct Evidence of an Enzyme-Generated LPP Intermediate in (+)-Limonene Synthase Using a Fluorinated GPP Substrate Analog. ACS chemical biology 10 31433159
2009 Expression of HMGA2-LPP and LPP-HMGA2 fusion genes in lipoma: identification of a novel type of LPP-HMGA2 transcript in four cases. Anticancer research 10 19528502
2008 Electrostatic contribution to the thermodynamic and kinetic stability of the homotrimeric coiled coil Lpp-56: A computational study. Proteins 10 17729276
2008 alpha-Actinin links LPP, but not zyxin, to cadherin-based junctions. Biochemical and biophysical research communications 10 18413140
2019 Single nucleotide polymorphism in the 3' untranslated region of LPP is a risk factor for lung cancer: a case-control study. BMC cancer 9 30621612
2017 Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis. International journal of environmental research and public health 9 28208589
2006 Stability and folding/unfolding kinetics of the homotrimeric coiled coil Lpp-56. Biochemistry 9 16846236
1967 Physical properties of the DNA from the blue-green algal virus LPP-1. Virology 9 18614061
2022 A Defect in Lipoprotein Modification by Lgt Leads to Abnormal Morphology and Cell Death in Escherichia coli That Is Independent of Major Lipoprotein Lpp. Journal of bacteriology 8 35938851
2020 Molecular dynamics simulation and experimental study of the surface-display of SPA protein via Lpp-OmpA system for screening of IgG. AMB Express 8 32880759
2011 TRIP6 and LPP, but not Zyxin, are present at a subset of telomeres in human cells. Cell cycle (Georgetown, Tex.) 8 21519191
2006 MRI characteristics of parosteal lipomas associated with the HMGA2-LPP fusion gene. Anticancer research 8 16821597
1985 Evolution of the lipoprotein gene in the enterobacteriaceae. Cloning and DNA sequence of the lpp gene from Proteus mirabilis. Journal of molecular biology 8 3903165
2023 Sequencing the genomes of LPP-1, the first isolated cyanophage, and its relative LPP-2 reveal different integration mechanisms in closely related phages. Harmful algae 7 37164560
2022 Circular RNA circLRCH3 Inhibits Proliferation, Migration, and Invasion of Colorectal Cancer Cells Through miRNA-223/LPP Axis. OncoTargets and therapy 7 35611368
2021 Membrane Stress Caused by Unprocessed Outer Membrane Lipoprotein Intermediate Pro-Lpp Affects DnaA and Fis-Dependent Growth. Frontiers in microbiology 6 34163454
2019 Does facial action modulate neural responses of emotion? An examination with the late positive potential (LPP). Emotion (Washington, D.C.) 6 31815498
2012 Association study of gene LPP in women with polycystic ovary syndrome. PloS one 6 23056290
2001 A novel LPP fusion gene indicates the crucial role of truncated LPP proteins in lipomas and pulmonary chondroid hamartomas. Cytogenetics and cell genetics 6 12063392
2002 Expression of the HMGA2-LPP fusion transcript in only 1 of 61 karyotypically normal pulmonary chondroid hamartomas. Cancer genetics and cytogenetics 5 12505264
2012 TGF-β1-induced LPP expression dependant on Rho kinase during differentiation and migration of bone marrow-derived smooth muscle progenitor cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 4 22886954
2022 LPP polymorphisms are risk factors for allergic rhinitis in the Chinese Han population. Cytokine 3 36084606
2019 3'UTR SNPs in the LPP gene associated with Immunoglobulin A nephropathy risk in the Chinese Han population. International immunopharmacology 3 31295688
2019 Attentional Processing of Facial Expressions and Gaze Direction in Depression and First-Episode Psychosis as Reflected by LPP Modulation. Clinical neuropsychiatry 3 34908933
2024 Association of LPP and ZMIZ1 Gene Polymorphism with Celiac Disease in Subjects from Punjab, Pakistan. Genes 2 39062631
2023 Long Non-Coding RNA LPP-AS2 Plays an Anti-Tumor Role in Thyroid Carcinoma by Regulating the miR-132-3p/OLFM1 Axis. Critical reviews in eukaryotic gene expression 2 37199315