Affinage

RCOR1

REST corepressor 1 · UniProt Q9UKL0

Length
485 aa
Mass
53.3 kDa
Annotated
2026-04-28
100 papers in source corpus 46 papers cited in narrative 46 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RCOR1 (CoREST) is the central scaffold of the CoREST repressor complex, coordinating histone H3K4 demethylation by LSD1/KDM1A and histone deacetylation by HDAC1/2 to regulate gene expression in neuronal, hematopoietic, immune, and other developmental contexts (PMID:11102443, PMID:16079794, PMID:32101746). Structurally, RCOR1 binds LSD1 through its linker region (forming a triple-helical bundle with the LSD1 tower domain) and engages nucleosomal and extranucleosomal DNA via its SANT2 domain, thereby enabling LSD1 to demethylate nucleosomal substrates that the enzyme alone cannot access; its ELM2-SANT1 region recruits HDAC1/2, and cryo-EM reveals a bi-lobed architecture with LSD1 and HDAC1 at opposite ends (PMID:16885027, PMID:32396821, PMID:11171972, PMID:32101746). Beyond canonical repression, RCOR1 associates with RNA Polymerase II at actively transcribed genes and deacetylates the Pol II CTD at lysine 7 to dampen productive elongation, and it serves as a recruitment hub for diverse transcription factors—including REST, Gfi-1/1b, Nurr1, ZNF750, INSM1, and Foxp3—that direct complex activity to specific genomic loci (PMID:35322029, PMID:10734093, PMID:17707228, PMID:19345186, PMID:25228645, PMID:28049845, PMID:31917688). Rcor1 is essential in vivo for erythropoiesis (knockout arrests erythroid progenitors at the proerythroblast-to-basophilic erythroblast transition), cortical neuron radial migration, and the neural progenitor-to-neuron transition, and its degradation is controlled by the CRL3-KBTBD4 ubiquitin ligase—a pathway exploited by disease-associated KBTBD4 mutations in medulloblastoma (PMID:24652990, PMID:21878487, PMID:28049845, PMID:35379950, PMID:39939761).

Mechanistic history

Synthesis pass · year-by-year structured walk · 20 steps
  1. 2000 High

    Identification of CoREST as a stable subunit of a novel HDAC1/2-containing complex (distinct from NuRD) that also contains LSD1 and interacts with REST established its identity as an independent chromatin-modifying scaffold rather than an accessory NuRD component.

    Evidence Biochemical fractionation, mass spectrometry, and Co-IP in mammalian cell extracts; yeast two-hybrid and domain mapping for REST interaction

    PMID:10734093 PMID:11102443

    Open questions at the time
    • Enzymatic activities attributable to the complex were uncharacterized
    • Stoichiometry of HDAC1 vs HDAC2 incorporation was undefined
    • Mechanism of CoREST–HDAC interaction was not structurally resolved
  2. 2001 High

    Mapping the HDAC1/2-interacting region of CoREST to a SANT-domain-containing segment and identifying ZNF217 as a binding partner showed that CoREST could function with transcription factors beyond REST.

    Evidence Biochemical purification, Co-IP, domain mapping, and functional repression assays

    PMID:11171972

    Open questions at the time
    • The SANT domain's role in chromatin binding was unknown
    • Whether ZNF217 and REST use the same or different interfaces on CoREST was unclear
  3. 2002 High

    Cross-species genetic rescue demonstrated functional conservation of CoREST from C. elegans to humans and placed it as a negative regulator of Notch signaling, broadening its roles beyond REST-dependent pathways.

    Evidence C. elegans suppressor screen with transgenic rescue using human CoREST

    PMID:12381669

    Open questions at the time
    • Molecular targets downstream of Notch regulated by CoREST were not identified
    • Whether this Notch connection operates in mammals was untested
  4. 2005 High

    Reconstitution experiments revealed that CoREST is absolutely required for LSD1-mediated demethylation of nucleosomal H3K4, resolving why purified LSD1 alone was inactive on chromatin substrates and establishing CoREST's core enzymatic role.

    Evidence In vitro demethylation with recombinant LSD1 ± CoREST on reconstituted nucleosomes; siRNA depletion and ChIP in cells

    PMID:16079794

    Open questions at the time
    • Structural basis for CoREST's enabling role was unknown
    • Whether other CoREST paralogs share this activity was untested
  5. 2006 High

    Crystal structures of the LSD1–CoREST complex revealed an elongated architecture with the SANT2 domain contacting DNA, and mutagenesis confirmed that SANT2–DNA interaction is required for nucleosomal demethylation—providing the first structural explanation for CoREST's enabling role.

    Evidence X-ray crystallography, mutagenesis, and enzymatic nucleosome demethylation assays; subsequent structures with substrate-like peptides

    PMID:16885027 PMID:17537733

    Open questions at the time
    • How the complex engages an intact nucleosome rather than free DNA/peptides was unknown
    • The HDAC1-binding arm was not captured structurally
  6. 2007 High

    Identification of Gfi-1/Gfi-1b SNAG domains as recruiters of the LSD1–CoREST complex to hematopoietic gene promoters established a paradigm for lineage-specific transcription factor–CoREST coupling and linked CoREST to erythroid, megakaryocytic, and granulocytic differentiation.

    Evidence Biochemical purification of Gfi-1b complexes, Co-IP, ChIP, and hematopoietic differentiation assays

    PMID:17707228

    Open questions at the time
    • Whether CoREST versus CoREST2/3 paralogs are differentially recruited by Gfi factors was unknown
    • In vivo genetic requirement for CoREST in erythropoiesis was not yet tested
  7. 2005 High

    Discovery that HSV-1 ICP0 targets CoREST to displace HDAC1 and block host gene silencing of viral DNA revealed CoREST as a critical node in innate antiviral chromatin defense.

    Evidence Co-IP, viral mutant analysis, subcellular fractionation; a truncated CoREST functionally replaced ICP0 in viral replication

    PMID:15897453 PMID:17939992

    Open questions at the time
    • Whether other herpesviruses exploit the same CoREST interface was unexplored
    • Structural basis of ICP0–CoREST interaction was not resolved
  8. 2008 Medium

    SUMOylation of CoREST at K294 modulates its repressive activity, and ZNF198 preferentially binds the intact LSD1–CoREST–HDAC1 ternary complex in a REST-mutually exclusive manner, revealing post-translational and compositional regulation of complex function.

    Evidence In vitro/in vivo SUMOylation assays, mutagenesis, transcriptional reporters; Co-IP and SUMO-dependent HDAC1 binding analysis

    PMID:18806873 PMID:18854179

    Open questions at the time
    • Physiological contexts requiring CoREST SUMOylation were uncharacterized
    • Whether SUMO modification affects complex stability versus activity was not separated in vivo
  9. 2009 High

    Demonstration that Nurr1 recruits the CoREST complex to NF-κB-p65 at inflammatory gene promoters in glia, clearing p65 and protecting dopaminergic neurons, expanded CoREST's role to anti-inflammatory neuroprotection.

    Evidence Co-IP, ChIP, Nurr1 knockdown, gene expression analysis, and neuronal death assays in microglia/astrocytes

    PMID:19345186

    Open questions at the time
    • Whether CoREST enzymatic activities (demethylation, deacetylation) are both required for this anti-inflammatory effect was unclear
    • Relevance to Parkinson's disease in vivo was not directly tested
  10. 2010 High

    Biophysical measurement of the LSD1–CoREST interaction (Kd ~16 nM, 1:1) and demonstration that LSD1 deletion destabilizes CoREST protein established mutual stabilization as a core principle of complex integrity.

    Evidence Isothermal titration calorimetry and structure-guided domain mapping; LSD1 conditional KO ES cells with Western blot and HDAC activity assays

    PMID:20713442 PMID:21142040

    Open questions at the time
    • Whether CoREST paralogs bind LSD1 with comparable affinity was not measured
    • Degradation pathway for orphan CoREST was not identified
  11. 2011 High

    In vivo CoREST depletion in developing mouse cortex arrested radial migration at the multipolar-to-bipolar transition in an LSD1-dependent but REST-independent manner, establishing a REST-independent developmental function for the complex.

    Evidence In utero electroporation with shRNA, live imaging, and immunohistochemistry

    PMID:21878487

    Open questions at the time
    • Target genes mediating the migration phenotype were not identified
    • Whether HDAC activity within the complex is also required was untested
  12. 2014 High

    Comparative analysis of CoREST paralogs revealed that RCOR1 and RCOR2 facilitate nucleosomal demethylation while RCOR3 competitively inhibits it (rescued by swapping in the RCOR1 SANT2 domain), and reciprocal paralog expression during hematopoietic differentiation steers erythroid versus megakaryocytic fate choices.

    Evidence In vitro nucleosome demethylation with domain chimeras; hematopoietic differentiation assays; CoREST1/2/3 enzymatic comparison with mutagenesis

    PMID:24820421 PMID:24843136

    Open questions at the time
    • Structural basis for RCOR3 inhibition was not determined
    • In vivo paralog switching mechanisms were uncharacterized
  13. 2014 High

    Conditional Rcor1 knockout in mice demonstrated that Rcor1 is essential for erythropoiesis, with arrest at the proerythroblast-to-basophilic erythroblast transition and aberrant CSF2-dependent STAT5 signaling—directly linking CoREST to in vivo hematopoietic disease biology.

    Evidence Conditional knockout mice, colony assays, gene expression profiling, ChIP, signaling pathway analysis

    PMID:24652990

    Open questions at the time
    • Whether pharmacological CoREST complex inhibition phenocopies the genetic knockout was untested
    • Redundancy with RCOR2 in erythropoiesis was not resolved
  14. 2015 High

    Demonstration that LSD1–CoREST acts as an 'ergonomic clamp' that detaches the H3 tail from nucleosomal DNA and that extranucleosomal DNA dramatically stimulates demethylase activity provided a biophysical model for how CoREST positions the complex on chromatin.

    Evidence Covalent nucleosome–enzyme conjugation, SAXS, photocrosslinking, and enzymatic assays with varying nucleosome substrates

    PMID:25730864 PMID:25916846

    Open questions at the time
    • How linker histone H1 or chromatin fiber compaction affects this mechanism was unknown
    • In vivo relevance of extranucleosomal DNA dependence was not tested
  15. 2017 High

    RCOR1/RCOR2 double knockout in mouse brain revealed perinatal lethality with excessive neural progenitors at the expense of neurons and oligodendrocyte precursors; INSM1 knockout phenocopied key phenotypes, connecting INSM1-directed CoREST complex activity to neural fate specification.

    Evidence Conditional double KO mice, Co-IP, gene expression profiling, phenotypic epistasis

    PMID:28049845

    Open questions at the time
    • Whether INSM1 recruits the complex via direct or indirect interaction was not structurally resolved
    • Individual contributions of RCOR1 versus RCOR2 in brain were only partially separated
  16. 2020 High

    Crystal and cryo-EM structures of the LSD1–CoREST complex on nucleosomes revealed that LSD1 binds extranucleosomal DNA ~100 Å from the core while CoREST makes bivalent histone–DNA contacts, and that LSD1 and HDAC1 activities are kinetically coupled in a bi-lobed ternary complex—providing the definitive structural model.

    Evidence X-ray crystallography of LSD1–CoREST on a 191-bp nucleosome; cryo-EM of the ternary complex; kinetic crosstalk assays

    PMID:32101746 PMID:32396821

    Open questions at the time
    • How the complex transitions between distinct kinetic states in vivo was unknown
    • Structural basis of HDAC1 recruitment via the ELM2-SANT1 region was not captured at high resolution
  17. 2020 High

    Demonstration that RCOR1 physically associates with Foxp3 in regulatory T cells and that its conditional deletion impairs Treg suppressive function and enhances antitumor immunity established CoREST as a regulator of immune tolerance.

    Evidence Co-IP, conditional Rcor1 knockout in Foxp3+ cells, flow cytometry, functional suppression assays, tumor models

    PMID:31917688

    Open questions at the time
    • Direct genomic targets of CoREST in Tregs were not identified
    • Whether LSD1 enzymatic activity is required for CoREST's Treg function was not tested
  18. 2022 High

    Discovery that RCOR1 associates with RNA Pol II at actively transcribed genes and non-canonically deacetylates the Pol II CTD at K7 to dampen productive elongation fundamentally expanded its functional repertoire beyond gene silencing.

    Evidence Genome-wide ChIP-seq, Co-IP with Pol II, biochemical CTD deacetylation assay, elongation assays

    PMID:35322029

    Open questions at the time
    • Whether this CTD deacetylation activity is HDAC1/2-mediated or intrinsic to RCOR1 was not fully resolved
    • How the complex is targeted to active versus repressed genes was mechanistically unclear
  19. 2022 High

    Identification of KBTBD4 as the CRL3 substrate receptor that targets CoREST for ubiquitylation and degradation—and that medulloblastoma-associated KBTBD4 insertions create neo-substrate recognition—provided a direct link between CoREST proteostasis and pediatric brain cancer.

    Evidence Biochemical ubiquitylation assays, proteomics, RNA-seq in patient tumors; subsequent cryo-EM of UM171-induced KBTBD4–HDAC1–CoREST complex

    PMID:35379950 PMID:39939761

    Open questions at the time
    • Whether other E3 ligases also regulate CoREST turnover was unknown
    • How inositol hexakisphosphate availability is regulated in cells to modulate degradation was not addressed
  20. 2023 High

    Discovery that GSE1 bridges USP22 to the CoREST complex to deubiquitinate H2BK120 upon DNA damage, affecting ATR signaling and γH2AX formation, expanded CoREST's functional scope to the DNA damage response.

    Evidence AP-MS, GSE1 knockout, phosphoproteomics, H2B ubiquitination assays

    PMID:37878419

    Open questions at the time
    • Whether CoREST's demethylase or deacetylase activities contribute to the DNA damage response was untested
    • The mechanism by which DNA damage triggers USP22 recruitment to CoREST was not elucidated

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: the structural basis of RCOR1's ELM2-SANT1 interaction with HDAC1/2 at atomic resolution; how the complex is selectively partitioned between repressive and active chromatin contexts (e.g., Pol II CTD deacetylation versus H3K4 demethylation); and the full extent of functional non-redundancy among RCOR1, RCOR2, and RCOR3 paralogs in specific tissues.
  • High-resolution structure of complete RCOR1-HDAC1/2 interface is lacking
  • In vivo mechanism selecting CoREST for active versus repressed gene association is undefined
  • Paralog-specific knockout phenotypes across tissues remain incomplete

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0042393 histone binding 6 GO:0060090 molecular adaptor activity 4 GO:0140110 transcription regulator activity 4 GO:0003677 DNA binding 3 GO:0140096 catalytic activity, acting on a protein 1
Localization
GO:0005694 chromosome 4 GO:0005634 nucleus 3
Pathway
R-HSA-4839726 Chromatin organization 7 R-HSA-74160 Gene expression (Transcription) 6 R-HSA-1266738 Developmental Biology 3 R-HSA-392499 Metabolism of proteins 3 R-HSA-168256 Immune System 1
Partners
FOXP3GFI1BHDAC1HDAC2INSM1KDM1ARESTZNF217
Complex memberships
CoREST complex (LSD1–RCOR1–HDAC1/2)REST–CoREST complex

Evidence

Reading pass · 46 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2001 CoREST is an integral component of a distinct HDAC1/2-containing complex (CoREST-HDAC complex) that lacks RbAp46/48. The HDAC1/2-interacting region of CoREST maps to a 179-aa region containing a SANT domain, and corepressor function of CoREST depends on this region. ZNF217 (not REST) was identified as an interacting partner in this complex. Biochemical purification, Co-immunoprecipitation, domain mapping Proceedings of the National Academy of Sciences of the United States of America High 11171972
2000 CoREST/kiaa0071 is a stable component of a 9.5S HDAC1/2-containing complex (complex cI) that also contains a FAD-dependent oxidoreductase (kiaa0601/LSD1). This complex is distinct from the NuRD complex and can contain HDAC1, HDAC2, or both. Biochemical fractionation, mass spectrometry, Co-immunoprecipitation The Journal of biological chemistry High 11102443
2000 CoREST interacts with the COOH-terminal repressor domain of REST, forming a complex in mammalian cells. mSin3A interacts with the NH2-terminal repressor domain of REST via its PAH2 domain. Both CoREST and mSin3A are required for full REST-mediated repression. Co-immunoprecipitation, yeast two-hybrid, domain mapping, functional repression assays The Journal of biological chemistry High 10734093
2005 CoREST is essential for LSD1 (BHC110)-mediated demethylation of H3K4 on nucleosomal substrates. Recombinant LSD1 alone cannot demethylate nucleosomes, but LSD1-containing complexes with CoREST can; CoREST enhances LSD1-nucleosome association. Depletion of CoREST in vivo leads to de-repression of REST target genes and increased H3K4 methylation. In vitro reconstitution with recombinant subunits, nucleosome demethylation assay, CoREST depletion (siRNA), ChIP Nature High 16079794
2006 Crystal structure of the LSD1-CoREST complex reveals an elongated structure with a long stalk connecting the LSD1 catalytic domain to the CoREST SANT2 domain. The CoREST SANT2 domain interacts with DNA, and disruption of SANT2-DNA interaction diminishes CoREST-dependent demethylation of nucleosomes by LSD1. X-ray crystallography, mutagenesis, enzymatic nucleosome demethylation assay Molecular cell High 16885027
2007 Crystal structure of LSD1-CoREST with a substrate-like peptide inhibitor reveals the structural basis for H3 tail recognition and how CoREST participates in substrate recognition. The SANT2 domain of CoREST and interactions of LSD1 with the H3 tail dictate the exquisite substrate specificity. X-ray crystallography, kinetic assays The Journal of biological chemistry High 17537733
2007 CoREST and LSD1 are recruited by transcriptional repressors Gfi-1 and Gfi-1b via the SNAG repression domain to mediate epigenetic repression at hematopoietic target gene promoters. CoREST and LSD1 association is required for differentiation of erythroid, megakaryocytic, and granulocytic cells. Biochemical purification of Gfi-1b complexes, Co-IP, ChIP, loss-of-function (inhibition/knockdown), lineage differentiation assays Molecular cell High 17707228
2005 During HSV-1 infection, the viral protein ICP0 binds to CoREST and dissociates HDAC1 from the CoREST/REST complex. CoREST and HDAC1 are subsequently phosphorylated by viral kinases and partially translocated to the cytoplasm, thus blocking silencing of viral genes. Co-immunoprecipitation, viral mutant analysis, subcellular fractionation, phosphorylation assays Proceedings of the National Academy of Sciences of the United States of America High 15897453
2007 ICP0 blocks silencing of HSV DNA by displacing HDAC1 from the CoREST-REST complex. A truncated CoREST (CoREST(146-482)) that displaces HDAC1 from CoREST-REST can functionally replace ICP0 in viral replication, demonstrating that ICP0's key anti-silencing function operates through CoREST. Viral recombinant construction and functional rescue, Co-IP mapping, viral yield assays Proceedings of the National Academy of Sciences of the United States of America High 17939992
2008 CoREST interacts with Hsp70 and represses HSF1-dependent transcriptional activation of the hsp70 promoter. CoREST is bound to the hsp70 gene promoter under basal conditions and its binding increases during heat shock response. Knockdown of CoREST prevents Hsp70-mediated repression of HSF1 and increases Hsp70 protein levels. Co-immunoprecipitation, reporter assays, shRNA knockdown, ChIP Molecular cell High 18657505
2008 ZNF198 binds preferentially to the intact LSD1-CoREST-HDAC1 (LCH) ternary complex rather than individual subunits. ZNF198 and REST binding to LCH are mutually exclusive. SUMO modification of HDAC1 weakens its interaction with CoREST but stimulates its binding to ZNF198. ZNF198 MYM-type zinc fingers mediate LCH and HDAC1-SUMO binding. Co-immunoprecipitation, in vitro SUMO modification assay, domain mapping PloS one Medium 18806873
2009 Nurr1 recruits the CoREST corepressor complex to NF-κB-p65 on target inflammatory gene promoters in microglia and astrocytes, resulting in clearance of NF-κB-p65 and transcriptional repression of pro-inflammatory neurotoxic mediators. This mechanism protects dopaminergic neurons from inflammation-induced death. Co-immunoprecipitation, ChIP, loss-of-function (Nurr1 knockdown), gene expression analysis, neuronal death assays Cell High 19345186
2010 LSD1 deletion in mouse ES cells reduces CoREST protein levels and associated HDAC activity, resulting in a global increase in histone H3-Lys56 acetylation. This demonstrates that LSD1 stabilizes CoREST protein within the LSD1/CoREST/HDAC complex. Conditional knockout ES cells, Western blot, HDAC activity assay, histone modification analysis Molecular and cellular biology High 20713442
2010 CoREST/REST siRNA destabilizes CoREST, REST, LSD1, and Sin3A simultaneously, indicating they are mutually stabilizing within the repressor complex. Depletion delays expression of HSV-1 alpha genes, but CoREST/REST complex is also subsequently inimical to viral gene expression. siRNA knockdown, viral gene expression analysis, protein stability assays mBio Medium 21221247
2011 CoREST depletion in vivo by in utero electroporation markedly delays the transition between multipolar and bipolar stages of newborn cortical pyramidal neurons and profoundly affects the onset of radial migration. This function requires LSD1 but is independent of REST. In utero electroporation, shRNA knockdown, live imaging, immunohistochemistry Cerebral cortex High 21878487
2012 Sumoylation of BRAF35 (a subunit of the LSD1-CoREST complex) is required to maintain full repression of neuron-specific genes and for LSD1-CoREST complex occupancy at target genes. iBraf heterodimerizes with BRAF35, impairs BRAF35 interaction with the LSD1-CoREST complex, and inhibits BRAF35 sumoylation, thereby promoting neuronal differentiation. Co-immunoprecipitation, ChIP, sumoylation assay, in vivo neural tube electroporation, differentiation assays Proceedings of the National Academy of Sciences of the United States of America High 22570500
2002 The C. elegans CoREST ortholog SPR-1 acts as a negative regulator of LIN-12/Notch signaling, functioning cell-autonomously in the nucleus. Human CoREST can substitute for SPR-1 in C. elegans, demonstrating functional conservation. SPR-5 (p110b homolog, a CoREST complex member) also participates in this repression. Genetic suppressor screen, epistasis, transgenic rescue with human CoREST, localization studies Genes & development High 12381669
2004 Drosophila CoREST interacts with the Ttk88 repressor (a functional analog of REST) to coordinately regulate neuronal-specific gene expression. Drosophila CoREST can interact with the same transcriptional partners as mammalian CoREST, but in flies the partner is Ttk88 rather than REST. Yeast two-hybrid, in vivo functional studies, gene expression analysis The Journal of neuroscience Medium 15306652
2008 SUMOylation of CoREST at lysine 294 by PIASxβ (E3 ligase) modulates its transcriptional repression activity. Mutation of the CoREST sumoylation site compromises its corepressor function. SENP1 desumoylates CoREST. In vitro and in vivo SUMOylation assay, mutagenesis, transcriptional reporter assays, Co-IP Biochemical and biophysical research communications Medium 18854179
2011 LSD1-CoREST crystal structure bound to a SNAIL1-derived peptide reveals that SNAIL1 N-terminal residues mimic the H3 tail binding to the enzyme active-site cleft, demonstrating molecular mimicry as a mechanism for LSD1 inhibition and regulation by transcription factors. X-ray crystallography, molecular dynamics simulations, enzymatic assays Structure High 21300290
2014 ZNF750 physically interacts with RCOR1, KDM1A, and CTBP1/2 through conserved PLNLS sequences. KDM1A colocalizes with ZNF750 at progenitor genes to facilitate their repression. RCOR1 and CTBP1/2 cooperate with ZNF750 for both progenitor gene repression and differentiation gene induction. Co-immunoprecipitation, ChIP-seq, gene depletion (shRNA), gene expression analysis Genes & development High 25228645
2014 Rcor2 and Rcor1 facilitate LSD1-mediated nucleosomal H3K4 demethylation, while Rcor3 competitively inhibits this process. Appending the SANT2 domain of Rcor1 to Rcor3 confers demethylation-facilitating ability. Reciprocal changes in Rcor1/Rcor3 levels during erythroid versus megakaryocytic differentiation potentiate antagonistic developmental outcomes. In vitro nucleosome demethylation assay, domain chimera construction, ChIP, hematopoietic differentiation assays, endogenous protein level analysis Proceedings of the National Academy of Sciences of the United States of America High 24843136
2014 CoREST1, CoREST2, and CoREST3 form complexes with LSD1/KDM1A and HDAC1/2 with distinct properties. CoREST2 shows lower interaction with HDAC1/2 due to a nonconserved leucine in its first SANT domain. CoREST3 shows reduced LSD1 catalytic efficiency and lower transcriptional repression than CoREST1. CoREST2 represses transcription in an HDAC-independent manner. Biochemical purification, Co-IP, LSD1 enzymatic assays, structural analysis, transcriptional reporter assays, mutagenesis Molecular and cellular biology High 24820421
2014 Rcor1 is essential for murine erythropoiesis. Rcor1-null erythroid progenitors arrest at the proerythroblast-to-basophilic erythroblast transition and aberrantly form myeloid colonies. CSF2RB is a direct target for both Rcor1 and Gfi1b in erythroid cells; absence of Rcor1 leads to CSF2-dependent phospho-Stat5 hypersensitivity. Conditional knockout mice, colony assays, gene expression profiling, ChIP, signaling pathway analysis Blood High 24652990
2015 LSD1-CoREST functions as an ergonomic clamp that induces detachment of the H3 histone tail from nucleosomal DNA to make it accessible for the active site. CoREST's SANT2 domain interacts with DNA, and this interaction is functionally essential for nucleosomal demethylation. Covalent nucleosome-enzyme conjugation, small-angle X-ray scattering, binding assays, site-directed mutagenesis Proceedings of the National Academy of Sciences of the United States of America High 25730864
2015 Extranucleosomal DNA dramatically enhances LSD1/CoREST demethylase activity on nucleosome substrates. Both LSD1 and CoREST subunits are in close contact with DNA around the nucleosome dyad and extranucleosomal DNA, and the complex binds the nucleosome as a 1:1 complex. Enzymatic activity assay, nucleosome binding assay, photocrosslinking Nucleic acids research High 25916846
2017 SUMO modification of histone H4 (suH4) stimulates LSD1-CoREST activity on nucleosome substrates through a mechanism dependent on the SUMO-interaction motif in CoREST. The stimulatory effect of suH4 is spatially limited and does not extend to adjacent nucleosomes. Semisynthetic nucleosome preparation, in vitro demethylation assay, SUMO-interaction motif mutagenesis ACS chemical biology High 28832116
2017 RCOR1 associates with RCOR2 in embryonic mouse brain as part of a complex with INSM1. RCOR1/RCOR2 double knockout causes perinatal death with an abnormally high number of neural progenitors at the expense of differentiated neurons and oligodendrocyte precursor cells. The Insm1 knockout phenocopies key brain phenotypes of the Rcor1/2 knockout, and REST transcripts are upregulated in both knockouts. Conditional double knockout mice, Co-IP, gene expression profiling, epistasis/rescue experiments Proceedings of the National Academy of Sciences of the United States of America High 28049845
2018 Corin, a dual HDAC/LSD1 inhibitor targeting the CoREST complex, shows more sustained inhibition of CoREST complex HDAC activity than entinostat alone. CoREST knockdown studies confirm that corin's effects depend on an intact CoREST complex. Enzymologic analysis, cell-based proliferation assays, ChIP, gene expression, mouse xenograft model, CoREST knockdown Nature communications High 29302039
2020 LSD1 and HDAC1 activities within the CoREST complex are closely coupled rather than functioning independently. The CoREST complex (with RCOR1 as scaffold) can exist in at least two distinct states with different kinetics. Electron microscopy reveals a bi-lobed structure with LSD1 and HDAC1 at opposite ends; the nucleosome-bound structure reveals a mode of chromatin engagement. Cryo-electron microscopy, electron microscopy, kinetic/enzymatic assays, ternary complex assembly Cell reports High 32101746
2020 Crystal structure of the LSD1/CoREST complex bound to a 191-bp nucleosome reveals that the LSD1 catalytic domain binds extranucleosomal DNA positioned ~100 Å from the nucleosome core, while CoREST makes critical contacts with both histone and DNA components of the nucleosome, explaining CoREST's essential role in enabling nucleosomal demethylation. X-ray crystallography, nucleosome binding and demethylation assays, mutagenesis Molecular cell High 32396821
2020 Rcor1 physically associates with Foxp3 in regulatory T cells (Tregs). Conditional deletion of Rcor1 in Foxp3+ Tregs decreases Treg proportions, increases IL-2 and IFN-γ expression, reduces suppression of homeostatic proliferation, and enhances antitumor immunity. Co-immunoprecipitation, conditional knockout mice, flow cytometry, functional Treg suppression assays, tumor models The Journal of clinical investigation High 31917688
2022 RCOR1 associates with RNA Polymerase II (POL-II) during transcription and deacetylates its carboxy-terminal domain (CTD) at lysine 7. This non-canonical activity dampens POL-II productive elongation at actively transcribing genes. RCOR1 is predominantly associated with transcriptionally active genes genome-wide (not just repressed targets). Genome-wide ChIP-seq, Co-IP, biochemical deacetylation assay on POL-II CTD, elongation assays Nature communications High 35322029
2022 In endocrine-sensitive breast cancer cells, CoREST is recruited to regulatory regions co-bound by ERα and FOXA1 to regulate the estrogen pathway. During reprogramming toward endocrine resistance, CoREST is recruited to AP-1 sites and promotes SWI/SNF recruitment to drive chromatin opening and gene activation, independently of LSD1 demethylase activity. ChIP-seq, genetic and pharmacological CoREST inhibition, gene expression analysis, xenograft models Nature structural & molecular biology High 36344844
2025 UM171 acts as a molecular glue to induce high-affinity interactions between the CRL3 substrate receptor KBTBD4 and HDAC1/2, leading to ubiquitylation and degradation of the LSD1-HDAC1-CoREST complex. Cryo-EM reveals an asymmetric assembly where a single UM171 enables a pair of KELCH-repeat propeller domains to recruit HDAC1; inositol hexakisphosphate acts as a second molecular glue stabilizing the interaction. Cryo-EM, proteomics, base editor scanning, chemical inhibitor studies, in vitro ubiquitylation assay Nature High 39939761
2022 Disease-associated in-frame insertions in KBTBD4 drive its recognition of CoREST as a neo-substrate for ubiquitylation and degradation, diverting epigenetic programmes and promoting increased stemness in group 3/4 medulloblastoma. Biochemical ubiquitylation assay, proteomics, RNA-seq, loss-of-function experiments Cell death and differentiation High 35379950
2010 Isothermal titration calorimetry shows LSD1 and CoREST(286-482) interact with a Kd of ~16 nM in a 1:1 stoichiometry. The central binding determinant lies within CoREST residues 293-380 ('linker' region), a central helix that forms a triple-helical bundle with the LSD1 tower domain. Isothermal titration calorimetry, structure-driven truncation/domain mapping Biochemistry High 21142040
2008 The CoREST complex (ZNF217/CoREST/HDAC1/2/LSD1/CtBP1/2) directly occupies the p15ink4b tumor suppressor promoter, repressing it. Loss of ZNF217 or TGF-β stimulation causes complex removal and p15ink4b activation, with changes in H3K4 dimethylation at the promoter. ChIP, ChIP-DSL (genome-wide), siRNA knockdown, gene expression analysis Molecular and cellular biology Medium 18625718
2012 ZNF217 and the CoREST complex target the p15ink4b promoter and recruit DNMT3A to maintain methylation. TGF-β treatment triggers loss of ZNF217/CoREST/DNMT3A and recruitment of SMAD2/3, CBP, and TDG to mediate active demethylation. ZNF217 overexpression prevents this active demethylation. ChIP, ChIP-seq, DNA immunoprecipitation (5mC/5hmC), siRNA knockdown, overexpression studies Molecular cell High 22560925
2019 AGS-associated mutations in RNase H2B impair its interaction with ZMYM3 and the CoREST complex (including HDAC2, KDM1A, and RCOR1). ZMYM3 acts as a scaffold mediating the interaction between RNase H2 and CoREST complex components. Co-immunoprecipitation, mutation analysis, protein interaction mapping PloS one Medium 30889214
2023 GSE1 forms a complex with the HDAC1/CoREST co-repressor complex and is required for binding of the deubiquitinase USP22 to CoREST and for deubiquitination of H2B K120 in response to DNA damage. Loss of GSE1 impairs ATR signaling and γH2AX formation upon DNA damage. Affinity purification mass spectrometry, phosphorylome analysis, GSE1 knockout cells, H2B ubiquitination assay Nucleic acids research High 37878419
2018 PIASγ interacts with CoREST1 (RCOR1) and its paralogs, acting both as a SUMO-2 E3 ligase and as a protein stabilizer. SUMOylation-deficient CoREST1 and CoREST3 mutants retain similar interaction profiles with LSD1 and HDAC1/2, indicating SUMOylation does not affect complex assembly but affects protein levels. Co-immunoprecipitation, in vitro/in vivo SUMOylation assay, mutagenesis, protein stability analysis The Biochemical journal Medium 29555846
2022 Proximity-dependent biotin identification (BioID) in HEK293T cells identifies 302 CoREST-associated proteins, including 16/18 known components and novel associations with histone readers (CHD3/4/6/7/8), writers (KMT2B/2D), and erasers (KDM2B). LSD1 interactome in ES cells is 67% dynamic across differentiation stages, including novel associations with MMB and ChAHP complexes. BioID proximity labeling, mass spectrometry, embryonic stem cell differentiation Molecular omics Medium 34709266
2007 NAC1 (a POZ/BTB protein) directly interacts with CoREST via its POZ/BTB domain. This interaction was demonstrated in multiple cell lines and in rat brain lysates, and is required for CoREST-mediated repression, as NAC1 siRNA reverses CoREST-mediated repression. Co-immunoprecipitation, GST pulldown, siRNA knockdown, reporter assays Journal of neurochemistry Medium 17254023
2014 p120-catenin directly binds the REST-CoREST complex and displaces it from established gene targets to permit transcriptional activation. p120-catenin levels modulate mRNA and protein levels of Oct4, Nanog, and Sox2 in mouse ES cells and affect differentiation toward neural fates. Co-immunoprecipitation, in vitro binding assays, ChIP, gene expression analysis, mESC differentiation assays Journal of cell science Medium 25074806
2012 A short Gfi-1B isoform (p32) associates with the LSD1-CoREST repressor complex more efficiently than the major p37 isoform. The SNAG domain of Gfi-1B recruits LSD1-CoREST only when dimethylated on lysine 8 (KSKK motif). Mutation of K8 prevents Gfi-1B p32-induced erythroid development. Co-immunoprecipitation, methyl-lysine modification assay, mutagenesis, erythroid differentiation assays Journal of cell science High 22399799

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2009 A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 770 19345186
2005 An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature 644 16079794
2008 The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience 558 19118166
2001 CoREST is an integral component of the CoREST- human histone deacetylase complex. Proceedings of the National Academy of Sciences of the United States of America 411 11171972
2007 Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Molecular cell 345 17707228
2006 Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Molecular cell 273 16885027
2000 Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. The Journal of biological chemistry 273 11102443
2007 Structural basis of LSD1-CoREST selectivity in histone H3 recognition. The Journal of biological chemistry 202 17537733
2000 The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex. The Journal of biological chemistry 202 10734093
2018 Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors. Nature communications 200 29302039
2005 Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells. Proceedings of the National Academy of Sciences of the United States of America 166 15897453
2010 Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability. Molecular and cellular biology 163 20713442
2007 Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complex. Proceedings of the National Academy of Sciences of the United States of America 156 17939992
2014 ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. Genes & development 121 25228645
2010 REST and CoREST are transcriptional and epigenetic regulators of seminal neural fate decisions. Cell cycle (Georgetown, Tex.) 118 21088488
2007 MeCP2 deficiency in the brain decreases BDNF levels by REST/CoREST-mediated repression and increases TRKB production. Epigenetics 117 18075316
2009 REST and CoREST modulate neuronal subtype specification, maturation and maintenance. PloS one 113 19997604
2020 Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex. Cell reports 102 32101746
2011 miR-124 acts through CoREST to control onset of Sema3A sensitivity in navigating retinal growth cones. Nature neuroscience 100 22138647
2020 Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate. Molecular cell 91 32396821
2012 TGF-β-dependent active demethylation and expression of the p15ink4b tumor suppressor are impaired by the ZNF217/CoREST complex. Molecular cell 89 22560925
2011 Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase LSD1-CoREST complex. Structure (London, England : 1993) 85 21300290
2009 Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation. PloS one 81 19888342
2015 Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation. Proceedings of the National Academy of Sciences of the United States of America 76 25730864
2008 The two functions of herpes simplex virus 1 ICP0, inhibition of silencing by the CoREST/REST/HDAC complex and degradation of PML, are executed in tandem. Journal of virology 73 18945770
2008 ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatin through its MYM-type zinc fingers. PloS one 72 18806873
2011 CoREST/LSD1 control the development of pyramidal cortical neurons. Cerebral cortex (New York, N.Y. : 1991) 71 21878487
2013 Increased binding of stroke-induced long non-coding RNAs to the transcriptional corepressors Sin3A and coREST. ASN neuro 63 24063527
2017 REST corepressors RCOR1 and RCOR2 and the repressor INSM1 regulate the proliferation-differentiation balance in the developing brain. Proceedings of the National Academy of Sciences of the United States of America 61 28049845
2012 LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition. Proceedings of the National Academy of Sciences of the United States of America 61 22802671
2012 Control of neuronal differentiation by sumoylation of BRAF35, a subunit of the LSD1-CoREST histone demethylase complex. Proceedings of the National Academy of Sciences of the United States of America 59 22570500
2014 MicroRNA targeting of CoREST controls polarization of migrating cortical neurons. Cell reports 58 24794437
2014 Differential properties of transcriptional complexes formed by the CoREST family. Molecular and cellular biology 57 24820421
2002 Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans. Genes & development 57 12381669
2014 Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation. Proceedings of the National Academy of Sciences of the United States of America 54 24843136
2013 Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase. ACS chemical biology 54 23721412
2010 Disruption of HDAC/CoREST/REST repressor by dnREST reduces genome silencing and increases virulence of herpes simplex virus. Proceedings of the National Academy of Sciences of the United States of America 54 20798038
2017 ZNF516 suppresses EGFR by targeting the CtBP/LSD1/CoREST complex to chromatin. Nature communications 53 28947780
2009 Engagement of the lysine-specific demethylase/HDAC1/CoREST/REST complex by herpes simplex virus 1. Journal of virology 53 19193804
2020 Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity. The Journal of clinical investigation 52 31917688
2008 Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex. Molecular and cellular biology 46 18625718
2004 A conserved role but different partners for the transcriptional corepressor CoREST in fly and mammalian nervous system formation. The Journal of neuroscience : the official journal of the Society for Neuroscience 42 15306652
2020 More than a Corepressor: The Role of CoREST Proteins in Neurodevelopment. eNeuro 39 32075869
2018 CoREST Complex-Selective Histone Deacetylase Inhibitors Show Prosynaptic Effects and an Improved Safety Profile To Enable Treatment of Synaptopathies. ACS chemical neuroscience 39 30496686
2014 MicroRNA-432 contributes to dopamine cocktail and retinoic acid induced differentiation of human neuroblastoma cells by targeting NESTIN and RCOR1 genes. FEBS letters 39 24657437
2008 CoREST represses the heat shock response mediated by HSF1. Molecular cell 39 18657505
2017 Chemically Sumoylated Histone H4 Stimulates Intranucleosomal Demethylation by the LSD1-CoREST Complex. ACS chemical biology 38 28832116
2015 Extranucleosomal DNA enhances the activity of the LSD1/CoREST histone demethylase complex. Nucleic acids research 38 25916846
2007 NAC1, a cocaine-regulated POZ/BTB protein interacts with CoREST. Journal of neurochemistry 37 17254023
2019 Epigenetic Regulator CoREST Controls Social Behavior in Ants. Molecular cell 36 31732456
2010 The CoREST/REST repressor is both necessary and inimical for expression of herpes simplex virus genes. mBio 36 21221247
2025 UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors. Nature 34 39939761
2014 p120-catenin regulates REST and CoREST, and modulates mouse embryonic stem cell differentiation. Journal of cell science 33 25074806
2012 A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-CoREST complex through the dimethylation of its SNAG domain. Journal of cell science 32 22399799
2008 NF-Y substitutes H2A-H2B on active cell-cycle promoters: recruitment of CoREST-KDM1 and fine-tuning of H3 methylations. Nucleic acids research 30 18940868
2014 Corepressor Rcor1 is essential for murine erythropoiesis. Blood 28 24652990
2012 CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster. Journal of cell science 28 22331351
2016 The chromatin modifying complex CoREST/LSD1 negatively regulates notch pathway during cerebral cortex development. Developmental neurobiology 26 27112428
2013 Differential transcriptional regulation of meis1 by Gfi1b and its co-factors LSD1 and CoREST. PloS one 26 23308270
2013 The role of the CoREST/REST repressor complex in herpes simplex virus 1 productive infection and in latency. Viruses 25 23628827
2013 Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin. PLoS computational biology 25 23874194
2022 Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation. Cell death and differentiation 23 35379950
2022 Endocrine resistance and breast cancer plasticity are controlled by CoREST. Nature structural & molecular biology 23 36344844
2019 Targeting the GFI1/1B-CoREST Complex in Acute Myeloid Leukemia. Frontiers in oncology 22 31649884
2006 lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans. Developmental biology 22 17070797
2022 Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells. PLoS pathogens 21 35797416
2012 LSD1/CoREST reversible opening-closing dynamics: discovery of a nanoscale clamp for chromatin and protein binding. Biochemistry 19 22468794
2010 Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST. Biochemistry 19 21142040
2022 Unveiling RCOR1 as a rheostat at transcriptionally permissive chromatin. Nature communications 18 35322029
2001 Identification and localization of M-CoREST (1A13), a mouse homologue of the human transcriptional co-repressor CoREST, in the developing mouse CNS. Mechanisms of development 18 11578870
2021 HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury. Scientific reports 17 33907245
2018 Role of Epigenetic Regulation by the REST/CoREST/HDAC Corepressor Complex of Moderate NANOG Expression in Chicken Primordial Germ Cells. Stem cells and development 17 30032710
2013 Molecular dynamics simulations indicate an induced-fit mechanism for LSD1/CoREST-H3-histone molecular recognition. BMC biophysics 16 24274367
2022 Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Molecular omics 15 34709266
2015 The Corepressor Rcor1 Is Essential for Normal Myeloerythroid Lineage Differentiation. Stem cells (Dayton, Ohio) 15 26119982
2021 Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank. Scientific reports 14 33742053
2010 Depletion of CoREST does not improve the replication of ICP0 null mutant herpes simplex virus type 1. Journal of virology 14 20106915
2022 Activation of ABCC Genes by Cisplatin Depends on the CoREST Occurrence at Their Promoters in A549 and MDA-MB-231 Cell Lines. Cancers 13 35205642
2019 Distinct CoREST complexes act in a cell-type-specific manner. Nucleic acids research 13 31701127
2008 Sumoylation of CoREST modulates its function as a transcriptional repressor. Biochemical and biophysical research communications 13 18854179
2022 TBX2 acts as a potent transcriptional silencer of tumour suppressor genes through interaction with the CoREST complex to sustain the proliferation of breast cancers. Nucleic acids research 12 35687133
2020 MYT1 attenuates neuroblastoma cell differentiation by interacting with the LSD1/CoREST complex. Oncogene 11 32251364
2002 The Xiro-repressed gene CoREST is expressed in Xenopus neural territories. Mechanisms of development 11 11744385
2016 Expression profiling of RE1-silencing transcription factor (REST), REST corepressor 1 (RCOR1), and Synapsin 1 (SYN1) genes in human gliomas. Journal of B.U.ON. : official journal of the Balkan Union of Oncology 10 27685921
2022 Efficacy of Vafidemstat in Experimental Autoimmune Encephalomyelitis Highlights the KDM1A/RCOR1/HDAC Epigenetic Axis in Multiple Sclerosis. Pharmaceutics 9 35890315
2019 Aicardi-Goutières Syndrome associated mutations of RNase H2B impair its interaction with ZMYM3 and the CoREST histone-modifying complex. PloS one 9 30889214
2011 Overexpression of either lysine-specific demethylase-1 or CLOCK, but not Co-Rest, improves long-term expression from a modified neurofilament promoter, in a helper virus-free HSV-1 vector system. Brain research 9 22208646
2023 Inhibition of the CoREST Repressor Complex Promotes Wound Re-Epithelialization through the Regulation of Keratinocyte Migration. The Journal of investigative dermatology 8 37633457
2020 RCOR1 directly binds to MED28 and weakens its inducing effect on cancer stem cell-like activity of oral cavity squamous cell carcinoma cells. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 8 32306431
2023 Gse1, a component of the CoREST complex, is required for placenta development in the mouse. Developmental biology 6 37019373
2023 GSE1 links the HDAC1/CoREST co-repressor complex to DNA damage. Nucleic acids research 6 37878419
2023 CREB3 facilitates Donafenib resistance in hepatocellular carcinoma cells via the LSD1/CoREST/p65 axis by transcriptionally activating long noncoding RNA ZFAS1. Translational oncology 6 38641372
2012 Drosophila LSD1-CoREST demethylase complex regulates DPP/TGFβ signaling during wing development. Genesis (New York, N.Y. : 2000) 6 22965777
2010 REST corepressor (CoREST) repression induces phenotypic gene regulation in advanced osteoarthritic chondrocytes. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 5 20973059
2023 REST, RCOR1 and RCOR2 expression is reduced in osteoarthritic chondrocytes and contributes to increasing MMP13 and ADAMTS5 expression through upregulating HES1. Cellular signalling 4 37442513
2020 Pilocarpine-induced seizures associate with modifications of LSD1/CoREST/HDAC1/2 epigenetic complex and repressive chromatin in mice hippocampus. Biochemistry and biophysics reports 4 33426312
2018 PIASγ controls stability and facilitates SUMO-2 conjugation to CoREST family of transcriptional co-repressors. The Biochemical journal 4 29555846
2017 Exploring the Active Center of the LSD1/CoREST Complex by Molecular Dynamics Simulation Utilizing Its Co-crystallized Co-factor Tetrahydrofolate as a Probe. Journal of chemical information and modeling 4 29161028
2025 The Histone Demethylase LSD1/ZNF217/CoREST Complex is a Major Restriction Factor of Epstein-Barr Virus Lytic Reactivation. Research square 3 39877093
2025 CoREST in pieces: Dismantling the CoREST complex for cancer therapy and beyond. Science advances 3 40479062