Affinage

RBM47

RNA-binding protein 47 · UniProt A0AV96

Length
593 aa
Mass
64.1 kDa
Annotated
2026-04-28
45 papers in source corpus 33 papers cited in narrative 33 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RBM47 is a three-RRM-domain RNA-binding protein that broadly regulates mRNA fate — splicing, stability, and editing — across epithelial, immune, and neural tissues. It binds predominantly to intronic and 3′UTR sequences of target mRNAs via GCAUG and AU-rich motifs, stabilizing transcripts such as DKK1, AXIN1, IFNAR1, and GSDMA to restrain Wnt/β-catenin signaling and promote epithelial identity, while also directing alternative splicing events including TJP1 exon 20 inclusion and SEC31A tissue-specific exon usage (PMID:24898756, PMID:31358901, PMID:40436629, PMID:41681975). RBM47 serves as an essential cofactor of the APOBEC1 C-to-U RNA editing complex, where it can substitute for A1CF; intestine-specific Rbm47 knockout virtually eliminates apoB mRNA editing (PMID:24916387, PMID:30309881). RBM47 undergoes ISGylation at K329, primed by S309 phosphorylation, to regulate immune gene expression, and its protein stability is itself controlled by OTUD4-mediated deubiquitination and m6A-dependent mRNA regulation (PMID:38036512, PMID:38553613).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 2013 Medium

    Early work established that RBM47 is a bona fide RNA-binding protein (not DNA-binding) and placed it genetically upstream of Wnt signaling in head development, providing the first functional framework for the gene.

    Evidence Zebrafish morpholino knockdown with wnt8a epistasis rescue and RNA-binding specificity assay

    PMID:24038582

    Open questions at the time
    • Mechanism by which RBM47 restrains Wnt8a signaling was not determined
    • Direct RNA targets in zebrafish not identified
  2. 2014 High

    Transcriptome-wide binding maps revealed that RBM47 binds broadly to mRNA introns and 3′UTRs and regulates both splicing and mRNA stability, with DKK1 mRNA stabilization identified as a tumor-suppressive mechanism — establishing RBM47 as a multi-modal post-transcriptional regulator.

    Evidence HITS-CLIP in mammalian cell lines with mRNA stability assays and loss-of-function cancer models

    PMID:24898756

    Open questions at the time
    • Precise cis-elements for stability regulation not mapped
    • In vivo tumor suppression not validated with genetic models at this point
  3. 2014 High

    Concurrent biochemical work demonstrated that RBM47 physically associates with APOBEC1 and can substitute for A1CF as a cofactor for C-to-U RNA editing, revealing a second major molecular activity distinct from mRNA stabilization.

    Evidence Co-immunoprecipitation, in vitro RNA editing reconstitution, Rbm47 knockout mouse

    PMID:24916387

    Open questions at the time
    • Structural basis of RBM47–APOBEC1 interaction unknown
    • Relative contribution of A1CF vs RBM47 in different tissues not yet resolved
  4. 2018 High

    Tissue-specific conditional knockouts resolved the relative contributions of A1CF and RBM47 to RNA editing: RBM47 is the dominant editing cofactor in the intestine whereas liver editing depends on both cofactors, and double knockout eliminates nearly all APOBEC1-dependent editing.

    Evidence Intestine- and liver-specific conditional knockout mice with quantitative RNA editing assays

    PMID:30309881

    Open questions at the time
    • Molecular basis for tissue-specific cofactor selectivity not determined
    • Non-apoB editing targets not fully characterized
  5. 2019 High

    The cis-regulatory logic of RBM47-dependent splicing was decoded: RBM47's first RRM domain recognizes a (U)GCAUG motif in flanking introns to promote TJP1 exon 20 inclusion, linking RBM47 loss to EMT-promoting isoform switching.

    Evidence Minigene splicing assays, RRM domain mutagenesis, isoform-specific functional rescue

    PMID:31358901

    Open questions at the time
    • Whether GCAUG motif governs all RBM47-regulated splicing events is unknown
    • Contribution of RRM2/RRM3 to splicing specificity not defined
  6. 2019 High

    Domain-mapping studies determined the minimal RBM47 regions required for APOBEC1-dependent editing and revealed species-specific differences in editing selectivity between human and mouse RBM47.

    Evidence HEK293T reconstitution with domain deletions and fluorescence-based editing assay

    PMID:30844405

    Open questions at the time
    • Structural basis for species-specific selectivity not resolved
    • Whether domain requirements differ for editing versus mRNA stability functions is untested
  7. 2019 Medium

    An unexpected transcription-factor-like activity was reported: RBM47 controls p53 promoter activity, adding a DNA-level regulatory mode to its repertoire, though this was at odds with earlier evidence of RNA-only binding.

    Evidence siRNA knockdown and p53 promoter-luciferase reporter assay

    PMID:31511650

    Open questions at the time
    • Direct DNA binding by RBM47 at the p53 promoter was not demonstrated
    • Transcription factor activity not reconciled with earlier finding that RBM47 does not bind DNA
  8. 2020 Medium

    RBM47's mRNA stabilization function was extended to the Wnt pathway negative regulator AXIN1 in NSCLC, providing a second mechanism (alongside DKK1) by which RBM47 suppresses Wnt/β-catenin signaling.

    Evidence RIP, mRNA stability assay, lentiviral knockdown with in vitro and in vivo tumor assays

    PMID:32891348

    Open questions at the time
    • Specific 3′UTR elements mediating AXIN1 stabilization not mapped
    • Relative importance of DKK1 vs AXIN1 stabilization in Wnt suppression not tested
  9. 2021 High

    RBM47 was shown to amplify type I interferon signaling by stabilizing IFNAR1 mRNA and retarding IFNAR1 protein degradation, establishing a role in antiviral innate immunity beyond its RNA editing and splicing functions.

    Evidence RIP, mRNA stability assay, multiple in vitro and in vivo virus infection models, ISRE reporter assay

    PMID:34160127

    Open questions at the time
    • Mechanism of IFNAR1 protein stabilization (whether direct or indirect) not fully resolved
    • Relationship between IFNAR1 stabilization and APOBEC1 editing activity unclear
  10. 2023 High

    Intestine-specific Rbm47 knockout mice revealed that RBM47 restrains intestinal stem cell proliferation and Wnt signaling in vivo; paradoxically, loss protects against colitis-associated cancer but promotes spontaneous polyposis, demonstrating context-dependent tumor modulation.

    Evidence Intestine-specific conditional knockout mice, organoids, ApcMin/+ crosses, radiation and chemical injury models

    PMID:37014710

    Open questions at the time
    • Molecular targets responsible for the paradoxical polyposis phenotype not identified
    • Whether splicing or stability targets drive the proliferative phenotype not separated
  11. 2023 Medium

    A new post-translational regulatory layer was uncovered: RBM47 undergoes ISGylation at K329 (dependent on S309 phosphorylation), and K329R knockin mice show impaired immune activation, linking a specific PTM to RBM47's immune-regulatory output.

    Evidence K329R knockin mouse model, site-specific nanobody-targeted E3 ligase ISGylation, immune phenotyping

    PMID:38036512

    Open questions at the time
    • How ISGylation alters RBM47 RNA-binding or protein interactions is unknown
    • Kinase responsible for S309 phosphorylation not identified beyond epinephrine stimulus
  12. 2024 Medium

    RBM47 protein stability was shown to be regulated by OTUD4-mediated deubiquitination, revealing that RBM47's tumor-suppressive output is itself controlled at the protein turnover level.

    Evidence Co-immunoprecipitation, ubiquitination assay, mRNA stability assay, in vivo rescue in ccRCC

    PMID:38553613

    Open questions at the time
    • E3 ubiquitin ligase targeting RBM47 for degradation not identified
    • Whether OTUD4 regulation is tissue-specific is unknown
  13. 2025 Medium

    RBM47 was identified as a tissue-specific splicing regulator of SEC31A, a COPII coat component, linking RBM47's splicing activity to lipid transport and vesicular trafficking — extending its function beyond cancer and immunity.

    Evidence Cross-tissue RNA-seq correlation analysis with experimental splicing validation and lipid transport assay

    PMID:40436629

    Open questions at the time
    • Cis-elements in SEC31A pre-mRNA recognized by RBM47 not mapped
    • Physiological consequence of SEC31A mis-splicing in Rbm47-null animals not tested

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include: the structural basis for RBM47's dual role in RNA editing versus mRNA stabilization, whether the reported transcription factor activity represents direct DNA binding, and the full spectrum of tissue-specific splicing programs controlled by RBM47 in vivo.
  • No crystal or cryo-EM structure of RBM47 alone or in complex with APOBEC1
  • Direct DNA-binding activity contradicts earlier RNA-specificity data and has not been reconciled
  • Genome-wide splicing maps in Rbm47-knockout tissues not yet generated

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0003723 RNA binding 13 GO:0140098 catalytic activity, acting on RNA 3 GO:0140110 transcription regulator activity 3
Localization
GO:0005634 nucleus 3 GO:0005829 cytosol 2
Pathway
R-HSA-8953854 Metabolism of RNA 6 R-HSA-162582 Signal Transduction 4 R-HSA-168256 Immune System 4 R-HSA-74160 Gene expression (Transcription) 3
Partners
A1CFAPOBEC1HNRNPMMAVSOTUD4RUNX1
Complex memberships
APOBEC1 editosome

Evidence

Reading pass · 33 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2014 RBM47 binds broadly to mRNAs, most prominently in introns and 3'UTRs (HITS-CLIP), and alters splicing and abundance of a subset of target mRNAs, including stabilizing DKK1 mRNA to inhibit tumor progression. Transcriptome-wide HITS-CLIP, mRNA stability assays, loss-of-function in cell line models eLife High 24898756
2014 RBM47 physically interacts with APOBEC1 and A1CF, can substitute for A1CF, and is necessary and sufficient for APOBEC1-mediated C-to-U RNA editing in vitro; editing is impaired in Rbm47-deficient mice. Co-immunoprecipitation, in vitro RNA editing reconstitution, Rbm47 knockout mouse model EMBO reports High 24916387
2018 A1CF and RBM47 function independently yet interact in a tissue-specific manner to regulate APOBEC1-dependent C-to-U RNA editing; intestine-specific Rbm47 knockout virtually eliminates apoB RNA editing, while liver-specific knockout reduces editing in a subset of targets; double knockout of A1cf and Rbm47 eliminates apoB editing and abrogates most other targets. Tissue-specific conditional knockout mice, RNA editing quantification in liver and intestine RNA High 30309881
2019 RBM47 promotes inclusion of exon 20 of TJP1 pre-mRNA by recognizing a (U)GCAUG motif in the downstream intronic region; the first RRM domain of RBM47 is critical for this alternative splicing regulation; TJP1 isoform lacking exon 20 enhances actin stress fiber assembly and promotes cell migration during EMT. Minigene splicing assays, RRM domain mutagenesis, wound healing assay, isoform-specific functional rescue Oncogene High 31358901
2019 RBM47 regulates p53 at the transcriptional level by controlling p53 promoter activity; RBM47 knockdown reduces p53 mRNA and protein levels, consequently reducing p21 expression and shifting irradiated cells from senescence to cell death. siRNA knockdown, p53 promoter-luciferase reporter assay, Flag-RBM47 overexpression Cell death and differentiation Medium 31511650
2019 APOBEC1 cofactors A1CF and RBM47 show differential RNA editing activity on APOB and other target RNAs; the minimal domain requirement of RBM47 for editing activity was determined; human vs. mouse RBM47 show clear differences in editing selectivity. HEK293T cell reconstitution with APOBEC1 + cofactor, fluorescence-based eGFP localization editing assay, domain deletion analysis Journal of molecular biology High 30844405
2018 RBM47 promotes IL-10 mRNA stability in B cells by binding to AU-rich elements in the 3'UTR of Il10 mRNA, thereby elevating IL-10 production and enhancing regulatory B cell immunosuppressive function. mRNA microarray, RNA immunoprecipitation (RIP), mRNA stability assay, overexpression in primary B cells Cellular & molecular immunology Medium 29844590
2020 RBM47 binds AXIN1 mRNA and stabilizes it, thereby enhancing suppression of Wnt/β-catenin signaling and inhibiting NSCLC cell proliferation, migration, and invasion. RNA immunoprecipitation, mRNA stability assay, lentiviral knockdown, in vitro and in vivo functional assays Surgical oncology Medium 32891348
2021 RBM47 binds to the 3'UTR of IFNAR1 mRNA, increases its stability, and retards IFNAR1 protein degradation, thereby amplifying type I interferon downstream signaling and conferring broad-spectrum antiviral activity. RNA immunoprecipitation, mRNA stability assay, multiple virus infection models in vitro and in vivo, ISRE reporter assay EMBO reports High 34160127
2021 RBM47 binds to the promoter of BCAT1 and regulates its transcription; RBM47 also binds hnRNPM and cooperatively regulates alternative splicing of multiple pre-mRNAs in nasopharyngeal carcinoma cells. ChIP, transcriptome analysis, Co-immunoprecipitation with hnRNPM, functional rescue experiments Journal of genetics and genomics Medium 34274258
2022 RBM47 directly binds and stabilizes lncRNA SNHG5; SNHG5 in turn inhibits ubiquitination and degradation of FOXO3 by recruiting USP21, promoting FOXO3 nuclear translocation that activates ATG3/ATG5 to induce autophagy; FOXO3 feeds back to activate RBM47 transcription, forming a loop. RIP, co-immunoprecipitation, ubiquitination assay, nuclear fractionation, in vitro and in vivo functional assays Cell death & disease Medium 35338124
2022 RBM47 stabilizes UPF1 mRNA by binding to its 3'UTR and also promotes UPF1 transcription as a transcription factor, thereby upregulating NMD activity and suppressing HCC progression. RNA immunoprecipitation, mRNA stability assay, promoter activity assay, xenograft tumor model Cell death discovery Medium 35831298
2022 RBM47 binds PTEN mRNA and stabilizes it; miR-181c/d-5p directly targets RBM47 mRNA to suppress its expression, thereby reducing PTEN stability and activating PI3K/AKT signaling in colorectal cancer. RNA pulldown, luciferase reporter assay, RIP, mRNA stability assay with actinomycin D, rescue experiments Molecular carcinogenesis Medium 36321407
2013 RBM47 specifically binds RNA but not single-stranded DNA; knockdown of rbm47 in zebrafish causes headless/small-head phenotypes rescued by wnt8a morpholino, placing rbm47 upstream of Wnt8a signaling in head development. RNA binding assay, morpholino knockdown in zebrafish, genetic rescue with wnt8a morpholino, microarray gene expression analysis Developmental dynamics Medium 24038582
2016 Rbm47 function is required in the embryo proper (not the visceral endoderm) for viability and growth; conditional inactivation using Cre/FLP-mediated approaches demonstrates tissue-specific requirement. Conditional knockout/restoration using FlEx gene-trap cassette with Cre and FLP recombinases in mice Genesis Medium 26789794
2020 Zebrafish RBM47 interacts with MAVS and promotes its lysosome-dependent degradation, changing MAVS cellular localization from cytoplasm to lysosome region, thereby suppressing downstream MITA and IRF3/7 activation and inhibiting IFN production. Co-immunoprecipitation, subcellular fractionation/localization, lysosome inhibitor assays, reporter assays for IFN pathway components Journal of immunology Medium 32859727
2013 RBM47 binds Nanog mRNA in mouse embryonic stem cells (but not Sox2 or Oct4 mRNA), as demonstrated by RNA-binding protein immunoprecipitation after overexpression of HA-tagged Rbm47. RIP followed by RT-PCR in mouse ESCs overexpressing HA-Rbm47 Molecular biology reports Low 23649762
2023 RBM47 undergoes ISGylation at lysine 329, dependent on prior S309 phosphorylation (induced by epinephrine); K329R knockin mice with defective RBM47-ISGylation show impaired immune activation and increased susceptibility to lung injury; RBM47-ISGylation regulates TSC22D3 mRNA expression. K329R knockin mouse model, site-specific nanobody-targeted E3 ligase ISGylation in human cells, cytokine/immune phenotyping Cell death discovery Medium 38036512
2024 Deubiquitinase OTUD4 directly interacts with RBM47 and promotes RBM47 protein stability via deubiquitination; stabilized RBM47 in turn regulates ATF3 mRNA stability, promoting ATF3-mediated ferroptosis in ccRCC. Co-immunoprecipitation, ubiquitination assay, mRNA stability assay, rescue experiments in vitro and in vivo Apoptosis Medium 38553613
2023 RBM47 binds to flanking introns of circFNDC3B to facilitate its biogenesis (back-splicing), resulting in reduced FNDC3B linear mRNA; the resulting circFNDC3B competitively inhibits IGF2BP1 binding to FNDC3B mRNA, further destabilizing it. RIP assay, RNA stability analysis, RNA-FISH, immunofluorescence, functional assays Cancer cell international Medium 38129874
2023 RBM47 stabilizes FBXO2 mRNA, promoting STAT3 phosphorylation in chondrocytes and advancing osteoarthritis; RBM47 knockdown alleviates IL-1β-induced inflammation, apoptosis, and ECM degradation. RIP, mRNA stability assay, STAT3 phosphorylation western blot, rescue experiments with FBXO2/STAT3 overexpression Biochemical genetics Medium 38070024
2025 RBM47 directly binds to the 3'UTR of ITGAV mRNA via AU-rich elements and promotes its degradation; miR-122 suppresses RBM47 expression, thereby elevating ITGAV levels, which activates latent TGF-β and promotes HCC metastasis. RIP, mRNA stability assay with AU-rich element mapping, luciferase reporter, functional rescue in vitro and in vivo PloS one Medium 40638600
2025 RBM47 destabilizes PD-L1 mRNA via 3'UTR binding, reducing PD-L1 expression and thereby enhancing T-cell proliferation and cytotoxicity against NSCLC cancer stem cells; m6A modification by METTL3/YTHDF1 decreases RBM47 expression. m6A methylated RIP-PCR, RIP, functional T-cell co-culture assay, in vitro and in vivo CSC assays Journal of thoracic disease Low 41376900
2025 RBM47 (via its RRM2 domain) binds to the 3'UTR of cGAS mRNA and enhances its stability, thereby activating the cGAS-STING pathway; RUNX1 directly binds the Rbm47 promoter and drives its transcription, placing RUNX1 upstream of RBM47 in this pathway. RIP (RRM2 domain interaction), ChIP (RUNX1 on Rbm47 promoter), mRNA stability assay, cGAS inhibitor rescue, mouse POCD model Communications biology Medium 41407921
2025 RBM47 regulates tissue-specific alternative splicing of SEC31A (a COPII component), and inclusion of an uncharacterized exon in SEC31A increases lipid transport; RBM47 was identified as the trans-acting splicing regulator by correlation of splicing with RBP expression across tissues and then validated experimentally. RNA-seq across human tissues, correlation analysis, experimental validation of RBM47-mediated SEC31A splicing, lipid transport functional assay RNA Medium 40436629
2026 RBM47 directly binds to the 3'UTR of GSDMA mRNA and stabilizes it; GSDMA is necessary for RBM47-induced mesenchymal-to-epithelial transition (MET), suppression of migration/invasion, pyroptosis induction, and chemosensitization to Oxaliplatin in CRC cells. RNA-Seq, RIP, mRNA stability assay, GSDMA knockdown rescue experiments, functional migration/invasion/pyroptosis assays Cancers Medium 41681975
2026 RBM47 binds to AU-rich elements in ENC1 mRNA and enhances ENC1 stability, thereby curbing NRF2 synthesis and nuclear translocation in macrophages during atherosclerosis, promoting oxidative stress. RIP, mRNA stability assay, AAV-mediated in vivo knockdown, NRF2 inhibitor rescue in vitro Biochemical pharmacology Medium 41962778
2024 RBM47 stabilizes PDIA6 mRNA by binding to its 3'UTR, maintaining PDIA6 expression to promote pancreatic cancer cell proliferation and immune evasion from NK cells. RIP, luciferase reporter assay, mRNA stability assay, rescue experiments, metabolomics Journal of translational medicine Low 39741300
2025 HDAC2 promotes RBM47 expression through H3K27 deacetylation; RBM47 in turn increases NONO expression in medulloblastoma cells, defining a HDAC2/RBM47/NONO oncogenic axis. ChIP-qPCR, luciferase reporter assay, qRT-PCR, western blot, lentiviral RNAi Translational oncology Low 41027284
2023 Intestine-specific Rbm47 knockout mice exhibit increased intestinal proliferation, abnormal villus morphology, upregulation of antioxidant and Wnt signaling pathways, and protection against colitis-associated cancer but increased spontaneous polyposis with age; RBM47 regulates alternative splicing of TJP1 mRNA in human colorectal cancer. Intestine-specific conditional knockout mouse (Rbm47-IKO), intestinal organoids, ApcMin/+ crosses, radiation/chemical injury models JCI insight High 37014710
2021 RBM47 inhibits K562 cell proliferation and cell cycle progression by binding HMGA2 mRNA and promoting its degradation, reducing HMGA2 protein expression. RIP, mRNA stability assay, CCK-8, flow cytometry, lentiviral overexpression/knockdown Zhongguo shi yan xue ye xue za zhi Low 34105460
2024 In glioblastoma, RBM47 stabilizes mRNAs of inflammatory genes and activates the NF-κB pathway; NF-κB acts as a transcription factor that in turn enhances RBM47 transcription, forming a positive feedback loop that promotes M2 macrophage polarization in the tumor microenvironment. RNA-immunoprecipitation (RIP), ChIP, RNA sequencing, immunofluorescence, western blot Phytomedicine Medium 38518642
2023 RBM47 interferes with the interaction between lncRNA HOXB-AS1 and p53 protein by directly binding HOXB-AS1, freeing p53 to enter the nucleus and activating p53 signaling in renal cell carcinoma; RBM47 expression is regulated by CBP/P300-mediated H3K27ac. RIP, Co-immunoprecipitation, nuclear fractionation, chromatin modification assay, functional assays Cell death discovery Medium 37660095

Source papers

Stage 0 corpus · 45 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer. eLife 120 24898756
2014 C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47. EMBO reports 94 24916387
2017 Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression. Scientific reports 80 28680090
2022 RBM47/SNHG5/FOXO3 axis activates autophagy and inhibits cell proliferation in papillary thyroid carcinoma. Cell death & disease 60 35338124
2020 The RNA-binding protein RBM47 inhibits non-small cell lung carcinoma metastasis through modulation of AXIN1 mRNA stability and Wnt/β-catentin signaling. Surgical oncology 45 32891348
2019 RBM47-regulated alternative splicing of TJP1 promotes actin stress fiber assembly during epithelial-to-mesenchymal transition. Oncogene 45 31358901
2019 The RNA-binding protein RBM47 is a novel regulator of cell fate decisions by transcriptionally controlling the p53-p21-axis. Cell death and differentiation 42 31511650
2018 Apobec1 complementation factor (A1CF) and RBM47 interact in tissue-specific regulation of C to U RNA editing in mouse intestine and liver. RNA (New York, N.Y.) 41 30309881
2021 RNA binding motif 47 (RBM47): emerging roles in vertebrate development, RNA editing and cancer. Molecular and cellular biochemistry 31 34499322
2018 Post-transcriptional regulator Rbm47 elevates IL-10 production and promotes the immunosuppression of B cells. Cellular & molecular immunology 30 29844590
2021 RNA-binding protein RBM47 stabilizes IFNAR1 mRNA to potentiate host antiviral activity. EMBO reports 27 34160127
2021 RNA-binding motif protein RBM47 promotes tumorigenesis in nasopharyngeal carcinoma through multiple pathways. Journal of genetics and genomics = Yi chuan xue bao 26 34274258
2013 rbm47, a novel RNA binding protein, regulates zebrafish head development. Developmental dynamics : an official publication of the American Association of Anatomists 26 24038582
2021 Identifying RBM47, HCK, CD53, TYROBP, and HAVCR2 as Hub Genes in Advanced Atherosclerotic Plaques by Network-Based Analysis and Validation. Frontiers in genetics 24 33519905
2019 Comparison of RNA Editing Activity of APOBEC1-A1CF and APOBEC1-RBM47 Complexes Reconstituted in HEK293T Cells. Journal of molecular biology 22 30844405
2022 RBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator. Cell death discovery 19 35831298
2023 RBM47 regulates intestinal injury and tumorigenesis by modifying proliferation, oxidative response, and inflammatory pathways. JCI insight 18 37014710
2020 Zebrafish RBM47 Promotes Lysosome-Dependent Degradation of MAVS to Inhibit IFN Induction. Journal of immunology (Baltimore, Md. : 1950) 17 32859727
2016 Conditional restoration and inactivation of Rbm47 reveal its tissue-context requirement for viability and growth. Genesis (New York, N.Y. : 2000) 17 26789794
2024 Dioscin decreases M2 polarization via inhibiting a positive feedback loop between RBM47 and NF-κB in glioma. Phytomedicine : international journal of phytotherapy and phytopharmacology 11 38518642
2024 Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells. Apoptosis : an international journal on programmed cell death 11 38553613
2013 RNA-binding protein Rbm47 binds to Nanog in mouse embryonic stem cells. Molecular biology reports 10 23649762
2022 Saponin from Platycodi radix inactivates PI3K/AKT signaling pathway to hinder colorectal cancer cell proliferation, invasion, and migration through miR-181c/d-5p/RBM47. Molecular carcinogenesis 8 36321407
2023 Dynamic RBM47 ISGylation confers broad immunoprotection against lung injury and tumorigenesis via TSC22D3 downregulation. Cell death discovery 7 38036512
2023 A RBM47 and IGF2BP1 mediated circular FNDC3B-FNDC3B mRNA imbalance is involved in the malignant processes of osteosarcoma. Cancer cell international 7 38129874
2022 RBM47 is a Critical Regulator of Mouse Embryonic Stem Cell Differentiation. Stem cell reviews and reports 6 35986129
2023 RBM47 restrains renal cell carcinoma progression and chemoresistance through interacting with lncRNA HOXB-AS1. Cell death discovery 5 37660095
2023 Post-Transcriptional Regulator RBM47 Stabilizes FBXO2 mRNA to Advance Osteoarthritis Development: WGCNA Analysis and Experimental Validation. Biochemical genetics 5 38070024
2024 Copy number amplification-induced overexpression of lncRNA LOC101927668 facilitates colorectal cancer progression by recruiting hnRNPD to disrupt RBM47/p53/p21 signaling. Journal of experimental & clinical cancer research : CR 4 39350250
2024 RBM47 promotes cell proliferation and immune evasion by upregulating PDIA6: a novel mechanism of pancreatic cancer progression. Journal of translational medicine 4 39741300
2023 RNA-Binding Motif Protein RBM47 Promotes Invasiveness of Glioblastoma Through Activation of Epithelial-to-Mesenchymal Transition Program. Genetic testing and molecular biomarkers 3 38156907
2025 Down-regulation of RBM47 due to diminished activation by forkhead box A1 (FOXA1) and silencing by CpG methylation is associated with epithelial-mesenchymal transition and metastasis of colorectal cancer. Molecular biomedicine 2 41335176
2023 Changes in RBM47 expression based on the timing of melatonin administration and its effects on Nrf2 activity in the hippocampus. Free radical biology & medicine 2 37751802
2025 RBM47 as a potential therapeutic target for thyroid-associated ophthalmopathy. International immunopharmacology 1 39746275
2025 MiR-122 promotes metastasis of hepatoma cells by modulating RBM47-integrin alpha V-TGF-beta signaling. PloS one 1 40638600
2021 [RNA Binding Protein RBM47 Inhibits the K562 Cell Proliferation by Regulating HMGA2 mRNA Expression]. Zhongguo shi yan xue ye xue za zhi 1 34105460
2026 RBM47-Induced Gasdermin A/GSDMA Mediates Mesenchymal-Epithelial Transition and Pyroptosis of Colorectal Cancer Cells. Cancers 0 41681975
2026 Unveiling the oncogenic function of CCDC12 in regulating RBM47 splicing in breast cancer. International journal of biological macromolecules 0 41690343
2026 RNA-binding protein RBM47 enhances ENC1 stability through AU-rich elements to induce oxidative stress in macrophages in atherosclerosis progression. Biochemical pharmacology 0 41962778
2025 Tissue-specific SEC31A alternative splicing is regulated by RBM47 and controls lipid transport. RNA (New York, N.Y.) 0 40436629
2025 RBM47 functions as an anti-oncogene by regulating expression and alternative splicing of cell proliferation and apoptosis associated genes in colorectal cancer cells. Scientific reports 0 40695891
2025 HDAC2 promotes malignant progression by the RBM47/NONO axis in medulloblastoma. Translational oncology 0 41027284
2025 Pseudomonas putida KT2440-induced RBM47 regulates non-small cell lung cancer stem cell properties and T cell-mediated antitumor activity. Journal of thoracic disease 0 41376900
2025 Microglial RUNX1/RBM47 ablation inhibits neuronal ferroptosis via regulating the cGAS-STING-MEF2C pathway in mice with postoperative cognitive dysfunction. Communications biology 0 41407921
2025 The role of positive feedback loop between LINC00862 and RBM47 in hepatocellular carcinoma suppression. Genes & diseases 0 41487470