Affinage

RBBP6

E3 ubiquitin-protein ligase RBBP6 · UniProt Q7Z6E9

Length
1792 aa
Mass
201.6 kDa
Annotated
2026-06-10
48 papers in source corpus 27 papers cited in narrative 28 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/7 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RBBP6 is a multidomain nuclear protein that couples pre-mRNA 3' end processing to ubiquitin-dependent protein turnover (PMID:25319826, PMID:18851979). Through its N-terminal DWNN domain — a ubiquitin-like fold first defined by NMR (PMID:16396680) — RBBP6 functions as an essential component of the mRNA 3' cleavage and polyadenylation machinery: it contacts core CPSF subunits including WDR33 and the endonuclease CPSF73/CPSF3 and is required to activate specific, efficient pre-mRNA cleavage; unlike its yeast homolog Mpe1 it is recruited to CPSF in an RNA-dependent manner rather than stably copurifying (PMID:35177536, PMID:35177537). The DWNN-only isoform 3 acts as an endogenous competitor that inhibits 3' processing by competing with full-length RBBP6 for the core machinery, and RBBP6 levels shape poly(A) site choice and the stability of AU-rich transcripts such as c-Fos and c-Jun (PMID:25319826). In parallel, RBBP6 is an E3 ubiquitin ligase whose RING finger/U-box-like domain adopts a homodimeric, zinc-coordinating fold (PMID:22130672) and directs ubiquitination of numerous substrates: it mediates K48-linked degradation of YB-1 (PMID:18851979), the replication regulator ZBTB38 (controlling MCM10 chromatin loading and replication fork progression) (PMID:24726359), IκBα to activate NF-κB-driven EMT (PMID:31685801), ERRα (PMID:39441040), Bmal1 (PMID:39501569), FOXP3 (PMID:40934694), and STAT1 (PMID:42011633), while K63-linked ubiquitination of CPSF3 stabilizes it to regulate alternative polyadenylation (PMID:38503731). RBBP6 localizes to nucleoli in interphase and to the chromosome periphery in mitosis, with protein levels rising over 10-fold during mitosis through post-transcriptional control (PMID:12064457), and it acts as a co-repressor of estrogen receptor-dependent transcription via SRC-1/ERα (PMID:20184719). RBBP6 additionally restricts viral replication, mimicking nucleoprotein binding to Ebola virus VP30 (PMID:30550789). The gene family is essential for development across metazoans (PMID:15733535, PMID:23536819).

Mechanistic history

Synthesis pass · year-by-year structured walk · 12 steps
  1. 1995 Medium

    Established the founding interaction that named the gene, placing RBBP6 in the orbit of retinoblastoma tumor-suppressor biology.

    Evidence GST pull-down of pRB with E1a competition mapping binding to the Rb pocket domain

    PMID:8595913

    Open questions at the time
    • Functional consequence of pRB binding not defined
    • No cellular pathway linked to the interaction
  2. 1997 Medium

    First implicated RBBP6 in nucleic-acid and RNP biology, hinting at an RNA-associated function later resolved as 3' processing.

    Evidence GST fusion binding to ssDNA and recognition by anti-hnRNP antibodies

    PMID:9037032

    Open questions at the time
    • No specific RNA target identified
    • Link to mRNA processing not yet established
  3. 2002 Medium

    Defined the cell-cycle-coupled localization and abundance of RBBP6, showing nucleolar-to-chromosome-periphery relocalization and >10-fold mitotic upregulation indicative of post-transcriptional control.

    Evidence Confocal microscopy and Western blot across synchronized mitotic cells; antisense knockdown and overexpression phenotyping

    PMID:12064457 PMID:12384997 PMID:12553003

    Open questions at the time
    • Molecular basis of post-transcriptional regulation unknown
    • Mechanism connecting localization to mitotic/apoptotic phenotypes unresolved
  4. 2005 Low

    Began assembling the RBBP6 interactome and its post-translational/translational regulation, linking it to splicing scaffolds and PUM2-mediated control.

    Evidence Co-IP with SAF-B and nucleolin, kinase assays, and PUM2 RNA pull-down with RT-PCR

    PMID:12938151 PMID:15617101

    Open questions at the time
    • Review-style/single-method evidence not independently confirmed
    • Functional impact of PUM2 binding on RBBP6 translation untested
  5. 2006 High

    Resolved the DWNN domain as a novel ubiquitin-like fold, establishing the structural basis for RBBP6's later-defined roles in ubiquitination and 3' processing.

    Evidence Heteronuclear NMR structure of the N-terminal 81 residues

    PMID:16396680

    Open questions at the time
    • Whether DWNN is conjugated like ubiquitin not determined
    • Binding partners of DWNN not yet mapped
  6. 2008 High

    Provided the first direct demonstration that RBBP6 is a functional E3 ligase, identifying YB-1 as a degradation substrate and establishing the RING domain's catalytic role.

    Evidence Yeast two-hybrid, in vitro ubiquitination, proteasomal degradation and reporter transactivation assays

    PMID:18851979

    Open questions at the time
    • Ubiquitin chain linkage type not defined
    • Physiological contexts of YB-1 regulation not mapped
  7. 2011 High

    Solved the RING/U-box-like domain structure and linked the DWNN to chaperones, framing RBBP6 as a chaperone-associated ubiquitination platform.

    Evidence Solution NMR structure with zinc/cadmium substitution and yeast two-hybrid with Hsp70/Hsp40

    PMID:22130672

    Open questions at the time
    • Functional role of Hsp70/Hsp40 binding in substrate selection untested
    • Dimerization requirement for ligase activity not demonstrated
  8. 2014 High

    Connected RBBP6's ligase activity to genome stability and definitively placed it in the mRNA 3' processing complex, unifying its two principal activities.

    Evidence shRNA/siRNA knockdown, ubiquitination and DNA fiber assays, in vitro 3' processing reconstitution, co-IP, and genome-wide poly(A) site analysis

    PMID:24726359 PMID:25319826

    Open questions at the time
    • How ubiquitination and 3' processing activities are coordinated unclear
    • Regulation of isoform 3 competition in vivo not defined
  9. 2018 High

    Revealed RBBP6 as a host restriction factor that disrupts Ebola virus transcription by molecular mimicry of viral nucleoprotein.

    Evidence AP-MS, domain mapping, X-ray crystallography of the VP30-RBBP6 peptide complex, and viral replication assays

    PMID:30550789

    Open questions at the time
    • Whether antiviral activity requires ligase function unknown
    • Endogenous cellular role of the mimicry motif not addressed
  10. 2022 High

    Established by reconstitution from purified components that RBBP6 is essential to activate the CPSF73 endonuclease, with RNA-dependent recruitment distinguishing it from yeast Mpe1.

    Evidence In vitro reconstitution of 3' cleavage with purified polypeptides, mutagenesis, structural analysis, and co-purification — independently replicated in two studies the same year

    PMID:35177536 PMID:35177537

    Open questions at the time
    • Atomic-resolution structure of the activated RBBP6-CPSF73 state not yet defined
    • Regulation of RNA-dependent recruitment unknown
  11. 2024 Medium

    Expanded the substrate repertoire and disease relevance of RBBP6 ubiquitination, including linkage-specific control of CPSF3 stability governing alternative polyadenylation.

    Evidence CRISPR screens, K63- and K48-linkage-specific ubiquitination assays, APA profiling, and conditional mouse models for ERRα and Bmal1

    PMID:38503731 PMID:39441040 PMID:39501569 PMID:39743259

    Open questions at the time
    • Determinants of K48 vs K63 linkage choice unresolved
    • Tissue specificity of substrate selection not mechanistically explained
  12. 2027 Medium

    Continued cataloguing RBBP6 degradation substrates in cancer contexts, linking it to FOXP3 and STAT1 turnover under defined transcriptional regulators.

    Evidence GST pull-down, co-IP, ubiquitination assays, ChIP/ChIP-re-ChIP and xenograft models

    PMID:40934694 PMID:42011633

    Open questions at the time
    • Whether these substrates share a common recognition motif unknown
    • Reciprocal validation of each interaction limited to single labs

Open questions

Synthesis pass · forward-looking unresolved questions
  • How RBBP6 partitions its activity between 3' end processing and substrate ubiquitination, and what governs substrate and chain-type selection, remains unresolved.
  • No unifying model coordinating the RNA-processing and E3-ligase functions
  • No defined degron or recognition logic across the diverse substrate set
  • Structural basis of RNA-dependent CPSF recruitment not solved

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016874 ligase activity 8 GO:0140096 catalytic activity, acting on a protein 4 GO:0003723 RNA binding 3 GO:0140098 catalytic activity, acting on RNA 3 GO:0031386 protein tag activity 1 GO:0140110 transcription regulator activity 1
Localization
GO:0005634 nucleus 3 GO:0005694 chromosome 1 GO:0005730 nucleolus 1
Pathway
R-HSA-392499 Metabolism of proteins 5 R-HSA-1643685 Disease 4 R-HSA-8953854 Metabolism of RNA 4 R-HSA-74160 Gene expression (Transcription) 2 R-HSA-69306 DNA Replication 1
Partners
CPSF3ERRAFOXP3SRC-1STAT1WDR33YB-1ZBTB38
Complex memberships
mRNA 3' cleavage and polyadenylation complex (CPSF)

Evidence

Reading pass · 28 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1995 RBBP6 (RBQ-1) binds to the retinoblastoma gene product (pRB) through a small region near its C-terminus, as demonstrated by GST pull-down of pRB from cellular extracts, with binding competed by adenovirus E1a protein indicating the interaction occurs through the pocket domain of Rb1. GST fusion protein pull-down, competition with E1a protein Genomics Medium 8595913
1997 P2P-R (RBBP6) encodes protein domains that bind single-stranded nucleic acids and associate with hnRNP proteins, as demonstrated by binding of cDNA-derived fusion proteins to ssDNA and recognition by anti-hnRNP monoclonal antibodies. GST fusion protein binding assay, monoclonal antibody recognition, antisense oligonucleotide experiments Proceedings of the National Academy of Sciences of the United States of America Medium 9037032
2002 P2P-R (RBBP6) localizes to nucleoli in interphase cells and to the periphery of chromosomes in mitotic cells, with protein levels increasing >10-fold during mitosis without a concomitant change in mRNA, suggesting post-transcriptional regulation. Confocal microscopy, Western blot, mitotic cell synchronization (nocodazole, vinblastine, shake-select) Journal of cellular physiology Medium 12064457
2002 Overexpression of near full-length P2P-R (RBBP6) in Saos2 cells restricts mitotic progression at prometaphase and promotes mitotic apoptosis, with P2P-R protein dissociating from chromosomes and appearing in cytoplasm and apoptotic cell surface blebs during mitotic apoptosis. Stable transfection, flow cytometry, confocal microscopy, Western blot of enriched apoptotic blebs Journal of cellular physiology Medium 12384997
2002 P2P-R (RBBP6) deficiency restricts cell cycle progression from G1 through S to mitosis in a microtubule-dependent manner and represses UV irradiation-induced apoptosis. Antisense oligonucleotide knockdown, flow cytometry, nocodazole treatment Anticancer research Low 12553003
2003 P2P-R (RBBP6) is phosphorylated by cdc2 and SRPK1a kinases, interacts with scaffold attachment factor-B (SAF-B), and co-immunoprecipitates with nucleolin. Co-immunoprecipitation, in vitro kinase assay (inferred from review-style paper) Journal of cellular biochemistry Low 12938151
2003 Overexpression of P2P-R (RBBP6) segments spanning residues 1156-1314 promotes camptothecin-induced apoptosis 3-5 fold in MCF-7 cells; the p53-binding domain overlaps with this apoptosis-associated region. Stable transfection, flow cytometry, TUNEL assay Journal of cellular physiology Medium 14566974
2005 PUM2 binds P2P-R (RBBP6) mRNA through consensus sequences in its 3' UTR, as confirmed by PUM2 pull-down followed by RT-PCR, suggesting translational regulation of RBBP6 by PUM2. RNA pull-down (PUM2 immunoprecipitation) followed by RT-PCR Journal of cellular physiology Low 15617101
2005 SNAMA, the Drosophila homolog of RBBP6, contains a DWNN domain and a RING finger-like motif; homozygous P-element insertion mutants show embryonic lethality with widespread apoptosis throughout the gastrula, establishing an essential developmental role for this gene family. P-element insertion genetics, embryo phenotype analysis Biochimica et biophysica acta Medium 15733535
2006 The N-terminal 81 amino acids of RBBP6 form a novel ubiquitin-like domain (DWNN) as determined by heteronuclear NMR; the domain lacks conserved K48/K63 equivalents but contains a di-glycine motif in human/mouse, and is independently expressed as a single-domain protein in vertebrates. Heteronuclear NMR structure determination BMC structural biology High 16396680
2008 RBBP6 acts as an E3 ubiquitin ligase for YB-1: the RING finger domain of RBBP6 binds the last 62 residues of YB-1 (identified by yeast two-hybrid), and both full-length RBBP6 and the isolated RING finger domain ubiquitinate YB-1 leading to its proteasomal degradation, suppressing YB-1 transactivational activity in vivo. Yeast two-hybrid, in vitro ubiquitination assay, proteasome degradation assay, reporter transactivation assay Journal of molecular biology High 18851979
2010 P2P-R (RBBP6) functions as a transcriptional co-repressor of estrogen-dependent transcription: it represses estrogen-induced transcription by 50-70% when transfected into four cell types, and co-immunoprecipitates with SRC-1 (steroid receptor co-activator 1) and estrogen receptor alpha. Transient transfection reporter assay, antisense knockdown, co-immunoprecipitation BMC systems biology Medium 20184719
2011 The RING finger-like domain of RBBP6 adopts a homodimeric structure similar to U-box proteins despite coordinating two zinc ions (replaceable with cadmium); RBBP6 interacts with chaperones Hsp70 and Hsp40 through its N-terminal DWNN ubiquitin-like domain, suggesting a role in chaperone-mediated ubiquitination. Solution NMR structure, zinc/cadmium substitution assays, thermal stability assays, yeast two-hybrid The Journal of biological chemistry High 22130672
2013 RBPL-1, the C. elegans homolog of RBBP6, is required for germ cell proliferation, oocyte production, embryonic development, and intestine development; RNAi silencing causes embryonic lethality and defects in mitosis, consistent with a role as an mRNA cleavage/polyadenylation factor. RNAi knockdown, phenotypic analysis, microarray expression profiling PloS one Medium 23536819
2014 RBBP6 ubiquitinates and destabilizes the transcriptional repressor ZBTB38; loss of RBBP6 causes ZBTB38 accumulation, leading to MCM10 downregulation on chromatin, reduced replication fork progression, and increased DNA damage at common fragile sites. shRNA knockdown, ubiquitination assay, chromatin fractionation, DNA fiber assay, FISH for fragile site stability Cell reports High 24726359
2014 RBBP6 is a component of the mRNA 3' processing complex and functions in 3' processing in vitro and in vivo; its DWNN ubiquitin-like domain mediates interaction with core cleavage/polyadenylation factors and is required for 3' processing activity. RBBP6 isoform 3 (iso3, DWNN-only) competes with full-length RBBP6 for binding to the core machinery, thereby inhibiting 3' processing. RBBP6 knockdown decreases transcript levels of AU-rich 3' UTR mRNAs (e.g., c-Fos, c-Jun) and increases usage of distal poly(A) sites. In vitro 3' processing assay, co-immunoprecipitation, genome-wide poly(A) site analysis, siRNA knockdown Genes & development High 25319826
2018 RBBP6 interacts with Ebola virus VP30 (transcription regulator) through a 23 amino acid region that mimics the viral nucleoprotein (NP) binding interface on VP30; a crystal structure of the VP30-RBBP6 peptide complex revealed competitive mimicry. RBBP6 knockdown stimulates viral transcription and increases EBOV replication; RBBP6 overexpression inhibits both. AP-MS, domain mapping, X-ray crystallography, siRNA knockdown, viral replication assays Cell High 30550789
2019 RBBP6 ubiquitinates IκBα (inhibitor of NF-κB), leading to its degradation and consequent p65 nuclear translocation, NF-κB pathway activation, EMT induction, and cancer cell metastasis in colorectal cancer. Co-immunoprecipitation, ubiquitination assay, nuclear fractionation, ChIP analysis, loss-of-function/gain-of-function experiments, mouse metastasis model Cell death & disease Medium 31685801
2021 The RING finger domain of RBBP6 binds SNRPG (small nuclear ribonucleoprotein polypeptide G) with a dissociation constant of ~3.16 nM as measured by microscale thermophoresis, confirming a physical interaction between these two splicing-related proteins. Microscale thermophoresis (MST) binding assay American journal of translational research Low 34956492
2022 RBBP6 is required to activate the human CPSF endonuclease for specific and efficient pre-mRNA 3' cleavage; unlike its yeast homolog Mpe1, RBBP6 does not stably copurify with CPSF but is recruited in an RNA-dependent manner. Sequence and mutational analyses indicate RBBP6 interacts with WDR33 and CPSF73 subunits of CPSF. In vitro reconstitution of 3' endonuclease activity with purified proteins, mutagenesis, co-purification experiments Genes & development High 35177536
2022 RBBP6 is required for pre-mRNA 3' end cleavage in a minimal reconstituted mammalian system; structural data show the RBBP6 DWNN domain contacts and presumably activates the endonuclease CPSF73. RBBP6 is among 14 polypeptides essential for RNA processing in vitro, and its role is conserved from yeast (Mpe1) to humans. In vitro reconstitution with 14 purified polypeptides, structural analysis, RNA cleavage assay at physiological poly(A) site Genes & development High 35177537
2024 RBBP6 mediates K63-linked ubiquitination of CPSF3 (Cleavage and Polyadenylation Specific Factor 3), which stabilizes CPSF3 and regulates alternative polyadenylation events in glioblastoma stem cells; RBBP6 depletion induces shortening of 3' UTRs of MYC competing-endogenous RNAs, releasing miR-590-3p to decrease MYC expression. CRISPR/Cas9 knockout screens, ubiquitination assay (K63-linkage specific), alternative polyadenylation profiling, miRNA-mRNA interaction analysis Cell discovery Medium 38503731
2024 RBBP6 promotes K48-linked polyubiquitination of ERRα at the K100 residue, leading to its proteasomal degradation; this contributes to mitochondrial injury in proximal renal tubular cells in diabetic kidney disease. RBBP6 inhibition or ERRα overexpression reduces mitochondrial damage in diabetic mice. Co-immunoprecipitation, ubiquitination assay (K48-linkage and site-specific mutagenesis), conditional knockout/overexpression mouse models, cellular fractionation Advanced science (Weinheim, Baden-Wurttemberg, Germany) Medium 39441040
2024 Rbbp6 promotes K48-linked ubiquitination and proteasomal degradation of Bmal1, which suppresses the YAP1 signaling pathway and promotes ferroptosis in diabetic testicular damage; co-immunoprecipitation confirmed the Rbbp6-Bmal1 interaction. Co-immunoprecipitation, ubiquitination assay, Western blot, ferroptosis marker analysis, knockdown/overexpression experiments Diabetes & metabolism journal Medium 39501569
2024 SRSF1-mediated alternative splicing regulates relative levels of RBBP6 isoform 1 vs isoform 3; knockdown of RBBP6 isoform 1 increases p53 protein levels in multiple myeloma cells, consistent with RBBP6 isoform 1 negatively regulating p53 through its ubiquitin ligase activity. siRNA knockdown, overexpression, Western blot, CCK-8 proliferation assay, RT-PCR Zhongguo shi yan xue ye xue za zhi Low 39743259
2025 RBBP6 inhibits Yellow Fever Virus (YFV) genome replication by interacting with the viral polymerase NS5, identifying RBBP6 as a restriction factor for YFV. AP-MS (affinity purification-mass spectrometry), functional viral replication assays bioRxivpreprint Low
2025 RBBP6 ubiquitinates and destabilizes FOXP3 via the ubiquitin-proteasome pathway in HBV-related hepatocellular carcinoma; RBBP6 knockdown restores FOXP3 expression and inhibits tumor formation in vivo. RFX5 transcriptionally activates RBBP6 in HBV-positive HCC cells. The interaction between FOXP3 and RBBP6 was confirmed by GST pull-down and co-immunoprecipitation. GST pull-down, co-immunoprecipitation, ubiquitination assay, ChIP, dual-luciferase reporter assay, xenograft mouse model Pathology, research and practice Medium 40934694
2026 RBBP6 ubiquitinates and degrades STAT1, suppressing DPP4 transcription; KMT2B enhances RBBP6 expression through H3K4me3 modification at the RBBP6 promoter. The RBBP6-STAT1 interaction was confirmed by co-immunoprecipitation and GST pull-down. ChIP-re-ChIP assay, co-immunoprecipitation, GST pull-down, ubiquitination assay Epigenomics Medium 42011633

Source papers

Stage 0 corpus · 48 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2018 Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication. Cell 129 30550789
2014 RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs. Genes & development 76 25319826
2008 RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1. Journal of molecular biology 75 18851979
2014 The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability. Cell reports 61 24726359
2006 DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways. BMC structural biology 59 16396680
2022 RBBP6 activates the pre-mRNA 3' end processing machinery in humans. Genes & development 47 35177536
1995 cDNA sequence and chromosomal localization of a novel human protein, RBQ-1 (RBBP6), that binds to the retinoblastoma gene product. Genomics 47 8595913
2022 Reconstitution of 3' end processing of mammalian pre-mRNA reveals a central role of RBBP6. Genes & development 38 35177537
1997 The proliferation potential protein-related (P2P-R) gene with domains encoding heterogeneous nuclear ribonucleoprotein association and Rb1 binding shows repressed expression during terminal differentiation. Proceedings of the National Academy of Sciences of the United States of America 37 9037032
2019 RBBP6, a RING finger-domain E3 ubiquitin ligase, induces epithelial-mesenchymal transition and promotes metastasis of colorectal cancer. Cell death & disease 34 31685801
2011 Expression and function of retinoblastoma binding protein 6 (RBBP6) in human lung cancer. Immunobiology 34 21676486
2014 Silencing RBBP6 (Retinoblastoma Binding Protein 6) sensitises breast cancer cells MCF7 to staurosporine and camptothecin-induced cell death. Immunobiology 32 24703106
2011 De-regulation of the RBBP6 isoform 3/DWNN in human cancers. Molecular and cellular biochemistry 30 22139301
2002 P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity. Journal of cellular physiology 24 12064457
2002 P2P-R protein overexpression restricts mitotic progression at prometaphase and promotes mitotic apoptosis. Journal of cellular physiology 24 12384997
2018 RBBP6 increases radioresistance and serves as a therapeutic target for preoperative radiotherapy in colorectal cancer. Cancer science 21 29369481
2011 Solution structure of RING finger-like domain of retinoblastoma-binding protein-6 (RBBP6) suggests it functions as a U-box. The Journal of biological chemistry 20 22130672
2003 Functional potential of P2P-R: a role in the cell cycle and cell differentiation related to its interactions with proteins that bind to matrix associated regions of DNA? Journal of cellular biochemistry 19 12938151
2003 Stable overexpression of specific segments of the P2P-R protein in human MCF-7 cells promotes camptothecin-induced apoptosis. Journal of cellular physiology 19 14566974
2024 RBBP6-Mediated ERRα Degradation Contributes to Mitochondrial Injury in Renal Tubular Cells in Diabetic Kidney Disease. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 16 39441040
2019 Expression Analysis of RbBP6 in human cancers: a Prospective biomarker. Anti-cancer drugs 15 31274515
2016 RBBP6: a potential biomarker of apoptosis induction in human cervical cancer cell lines. OncoTargets and therapy 15 27536134
2024 RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation. Cell discovery 14 38503731
2018 RBBP6 promotes human cervical carcinoma malignancy via JNK signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 14 29501043
2005 P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA. Journal of cellular physiology 12 15617101
2005 SNAMA, a novel protein with a DWNN domain and a RING finger-like motif: a possible role in apoptosis. Biochimica et biophysica acta 11 15733535
2021 MicroRNA‑193a‑5p exerts a tumor suppressive role in epithelial ovarian cancer by modulating RBBP6. Molecular medicine reports 10 34132380
2023 Cannabidiol and Cannabis Sativa as a potential treatment in vitro prostate cancer cells silenced with RBBp6 and PC3 xenograft. Molecular biology reports 9 36853473
2016 Expression analysis and association of RBBP6 with apoptosis in colon cancers. Journal of molecular histology 9 26905308
2013 The C. elegans Homolog of RBBP6 (RBPL-1) regulates fertility through controlling cell proliferation in the germline and nutrient synthesis in the intestine. PloS one 9 23536819
2002 P2P-R deficiency modifies nocodazole-induced mitotic arrest and UV-induced apoptosis. Anticancer research 9 12553003
2021 The lncRNA SLCO4A1-AS1/miR-876-3p/RBBP6 axis regulates cell proliferation and apoptosis in acute lymphocytic leukemia via the JNK signaling pathway. International journal of laboratory hematology 8 33683013
2018 RBBP6 expressional effects on cell proliferation and apoptosis in breast cancer cell lines with distinct p53 statuses. Cancer management and research 7 30237738
2010 Systems genetics analyses predict a transcription role for P2P-R: molecular confirmation that P2P-R is a transcriptional co-repressor. BMC systems biology 7 20184719
2024 Rbbp6-Mediated Bmal1 Ubiquitination Inhibits YAP1 Signaling Pathway to Promote Ferroptosis in Diabetes-Induced Testicular Damage. Diabetes & metabolism journal 6 39501569
2020 RBBP6 aggravates the progression of ovarian cancer by targeting PIK3R6. European review for medical and pharmacological sciences 6 33155192
2019 Downregulation of RBBP6 variant 1 during arsenic trioxide-mediated cell cycle arrest and curcumin-induced apoptosis in MCF-7 breast cancer cells. Future science OA 5 31534777
2024 Probing the Effects of Retinoblastoma Binding Protein 6 (RBBP6) Knockdown on the Sensitivity of Cisplatin in Cervical Cancer Cells. Cells 4 38667315
2019 RBBP6 Is Abundantly Expressed in Human Cervical Carcinoma and May Be Implicated in Its Malignant Progression. Biomarkers in cancer 4 30886526
2023 Expression, purification, and characterisation of the p53 binding domain of Retinoblastoma binding protein 6 (RBBP6). PloS one 3 36763571
2023 Abnormal expression of long non-coding RNA FGD5-AS1 affects the development of ovarian cancer through regulating miR-107/RBBP6 axis. The Chinese journal of physiology 2 37322627
2021 Microscale thermophoresis analysis of the molecular interaction between small nuclear ribonucleoprotein polypeptide G and the RING finger domain of RBBP6 towards anti-cancer drug discovery. American journal of translational research 2 34956492
2024 Mbnl1-mediated alternative splicing of circMlxipl regulates Rbbp6-involved ChREBP turnover to inhibit lipotoxicity-induced β-cell damage. Molecular medicine (Cambridge, Mass.) 1 39580381
2024 [The Impact of SRSF1 -Mediated Alternative Splicing of RBBP6 on the Proliferation of Multiple Myeloma Cells]. Zhongguo shi yan xue ye xue za zhi 1 39743259
2015 The association of RBBP6 variant 3 expressions with apoptosis in human immunodeficiency virus-associated nephropathy (HIVAN). Experimental and molecular pathology 1 25910411
2026 KMT2B induces the H3K4 trimethylation of RBBP6 promoter to enhance the 131I sensitivity in thyroid carcinoma by restraining STAT1/DPP4 axis. Epigenomics 0 42011633
2026 RBBP6 and cancer: from molecular mechanisms to clinical implications. Frontiers in oncology 0 42239902
2025 RBBP6-induced destabilization of FOXP3 promotes glucose metabolism and malignant progression of HBV-related hepatocellular carcinoma. Pathology, research and practice 0 40934694

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