Affinage

RAB34

Ras-related protein Rab-34, isoform NARR · UniProt P0DI83

Length
198 aa
Mass
21.1 kDa
Annotated
2026-04-28
47 papers in source corpus 24 papers cited in narrative 24 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

RAB34 is a small GTPase that functions at the intersection of Golgi-associated membrane trafficking, lysosome positioning, macropinocytosis, and primary ciliogenesis. In its GTP-bound state, RAB34 recruits the effector RILP via switch I residue K82 to drive dynein-dependent retrograde lysosome clustering toward the peri-nuclear region, within a pathway activated by the GEF DENND6A downstream of Arl8b on peripheral lysosomes (PMID:12475955, PMID:38296963). RAB34 is selectively required for the intracellular ciliogenesis pathway, where it localizes to the mother centriole and is essential for ciliary vesicle formation; its unique N-terminal LPQ motif and GTP hydrolysis cycle are both necessary for this function, and bi-allelic pathogenic variants in RAB34 cause oral-facial-digital syndrome in humans (PMID:33989527, PMID:33989524, PMID:37384395). RAB34 additionally promotes macropinosome formation downstream of Rac1/WAVE2, mediates intra-Golgi protein transport through its effector Munc13-2, and drives phagolysosome biogenesis independently of Rab7 (PMID:12446704, PMID:17881736, PMID:23197834).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 2002 High

    Establishing that RAB34 is a Golgi-localized GTPase that controls lysosome positioning through direct, GTP-dependent recruitment of the effector RILP answered the fundamental question of what this orphan Rab does and identified its first effector mechanism.

    Evidence Overexpression of wild-type/mutant Rab34, GST pull-down with recombinant proteins, K82 mutagenesis, immunofluorescence in mammalian cells

    PMID:12475955

    Open questions at the time
    • No GEF or GAP identified for Rab34 at this stage
    • Physiological context for lysosome repositioning unclear
    • Whether RILP interaction is competitive with or independent of Rab7 binding not resolved
  2. 2002 High

    Concurrent discovery that RAB34 localizes to membrane ruffles and promotes macropinosome formation downstream of Rac1/WAVE2 revealed a second, spatially distinct function beyond the Golgi, raising the question of how one Rab operates at two compartments.

    Evidence In vitro GTPase assay, fluorescence microscopy, dominant-negative epistasis with Rac1/WAVE2, PDGF stimulation

    PMID:12446704

    Open questions at the time
    • GAP identity not identified despite evidence of in vivo but not in vitro GTPase activity
    • Mechanism coupling Rac1/WAVE2 to Rab34 activation unknown
  3. 2003 High

    Mapping the RILP domain (aa 272–333) shared for Rab7 and Rab34 binding clarified how two distinct Rabs converge on the same effector to regulate lysosome dynamics.

    Evidence Yeast two-hybrid, GST pull-down, chimeric domain-transfer experiments

    PMID:14668488

    Open questions at the time
    • Whether Rab34 and Rab7 compete for RILP in vivo or form distinct complexes unclear
    • Structural basis of dual recognition not determined
  4. 2005 Medium

    Identification of Munc13-2 (via its MHD-2 domain) as a second GTP-dependent effector of RAB34 at the Golgi opened the question of how RAB34 coordinates secretory transport distinct from lysosome positioning.

    Evidence Bacterial two-hybrid screen, co-immunoprecipitation, GST pull-down with GTP/GDP-locked mutants

    PMID:16138900

    Open questions at the time
    • Functional consequence of Rab34–Munc13-2 interaction on secretion not yet demonstrated at this stage
    • No structural data on MHD-2–Rab34 interface
  5. 2007 High

    Demonstrating that RAB34 depletion blocks intra-Golgi VSVG transport without affecting ER-to-medial-Golgi traffic placed RAB34 specifically at a post-medial Golgi step in the secretory pathway, defining its second major cellular function.

    Evidence Immunoelectron microscopy, RNAi, dominant-negative expression, VSVG-GFP trafficking/EndoH resistance assay

    PMID:17881736

    Open questions at the time
    • Cargo specificity beyond VSVG not tested
    • Relationship between Munc13-2 effector and this trafficking step not functionally linked yet
  6. 2007 High

    Showing that dominant-negative RAB34 blocks coxsackievirus B entry and occludin internalization via macropinocytosis demonstrated a physiological role for RAB34-dependent macropinocytosis in pathogen entry.

    Evidence Dominant-negative Rab34, siRNA, CVB infection and endocytosis assays in polarized epithelial cells

    PMID:18005733

    Open questions at the time
    • Whether Rab34 is generally required for macropinocytosis or specific to tight-junction-associated endocytosis unclear
  7. 2009 Medium

    Functionally linking the Rab34–Munc13-2 complex to regulated protein secretion (glucose-stimulated VSVG and fibronectin secretion) closed the gap between effector identification and secretory pathway function.

    Evidence siRNA knockdown of Rab34 and Munc13-2, MHD2-deletion rescue, VSVG-GFP and fibronectin secretion assays

    PMID:19641095

    Open questions at the time
    • Whether Rab34–Munc13-2 mediates vesicle fusion or tethering not resolved
    • Tissue specificity of this regulated secretion axis not explored
  8. 2012 High

    Demonstrating that RAB34 recruits Munc13-2 to phagosomes for lysosome–phagosome fusion independently of Rab7 revealed an unexpected role in innate immunity and established that Rab34 and Rab7 control parallel phagosome maturation pathways.

    Evidence siRNA knockdown, active Rab34 overexpression, phagolysosome fusion and mycobacterial survival assays, Rab7 epistasis

    PMID:23197834

    Open questions at the time
    • Signal that activates Rab34 on phagosomes not identified
    • Whether this pathway operates in professional phagocytes in vivo not shown
  9. 2016 High

    Reconstitution showing that Folliculin (FLCN) loads active Rab34 onto RILP to form a ternary complex—without acting as a Rab34 GEF—revealed a novel regulatory mechanism for lysosome clustering under nutrient stress.

    Evidence Purified recombinant protein binding assay, GEF assay (negative), live-cell lysosome motility imaging

    PMID:27113757

    Open questions at the time
    • Identity of the actual Rab34 GEF still unknown at this point
    • In vivo physiological relevance of FLCN–Rab34–RILP ternary complex not tested
  10. 2018 High

    Discovery that Rab34 loss in mice causes polydactyly, cleft lip/palate, and failure of Hedgehog signaling due to defective ciliary vesicle formation at the mother centriole established RAB34 as a ciliogenesis factor, a function not predicted from its Golgi/lysosome roles.

    Evidence Mouse knockout, electron microscopy, Gli3 processing assay, phenotypic analysis

    PMID:30301781

    Open questions at the time
    • Whether Rab34 acts at the centriole directly or via vesicle delivery unknown
    • Upstream activation signal for Rab34 in ciliogenesis not identified
  11. 2018 High

    Identification of Src-mediated phosphorylation at Y247 as a regulator of Rab34 membrane ruffle translocation and integrin β3 trafficking revealed a post-translational switch modulating Rab34 activity in cell migration.

    Evidence In vitro kinase assay, phosphomimetic/phospho-dead mutants, co-immunoprecipitation with integrin β3, migration/invasion assays

    PMID:29622794

    Open questions at the time
    • Phosphatase that reverses Y247 phosphorylation not identified
    • Whether Y247 phosphorylation affects ciliogenesis or lysosome positioning not tested
  12. 2021 High

    Systematic Rab screens and KO studies in multiple cell lines converged to show that RAB34 is selectively required for the intracellular (not extracellular) ciliogenesis pathway, with both its unique N-terminal LPQ motif and GTPase cycle essential, defining its pathway-specific mechanism.

    Evidence Genome-wide siRNA screen of 62 Rabs, CRISPR KO in RPE1/NIH3T3/MCF10A/IMCD3, BioID proximity proteomics, electron microscopy, GTPase and N-terminal deletion/mutation rescue assays

    PMID:32669361 PMID:33860735 PMID:33989524 PMID:33989527

    Open questions at the time
    • Direct ciliogenesis effector of Rab34 at the mother centriole not identified
    • How N-terminal LPQ motif mechanistically contributes (binding partner?) unknown
  13. 2023 Medium

    Human genetic validation came when bi-allelic RAB34 missense variants clustered near the C-terminus were shown to cause oral-facial-digital syndrome with loss of ciliogenesis function, directly linking the mouse phenotype to a human ciliopathy.

    Evidence Exome sequencing, patient-derived cell ciliogenesis and immunofluorescence assays

    PMID:37384395

    Open questions at the time
    • Genotype-phenotype correlation across variant positions not fully resolved
    • Whether partial loss-of-function alleles produce milder ciliopathy spectrum unknown
  14. 2024 High

    Identification of DENND6A as the long-sought GEF for Rab34, activated by Arl8b on peripheral lysosomes, completed the Arl8b→DENND6A→Rab34→RILP/dynein signaling axis for nutrient-dependent lysosome positioning and autophagic flux.

    Evidence Cell-based GEF screen, biochemical GEF assay, pulldown with purified proteins, epistasis experiments, autophagic flux assay

    PMID:38296963

    Open questions at the time
    • Whether DENND6A also activates Rab34 for ciliogenesis not tested
    • GAP for Rab34 remains unidentified
    • Structural basis of DENND6A–Rab34 interaction not resolved
  15. 2024 Medium

    Expanding RAB34's trafficking roles, new studies showed it regulates type I collagen ER-to-Golgi transport and, in adipocytes, translocates to lipid droplets to control lipolysis via UBA1-mediated FABP5 degradation, revealing tissue-specific functions beyond canonical Golgi/lysosome biology.

    Evidence siRNA knockdown, proteomic interactome analysis, adiponectin secretion/lipolysis assays, mouse conditional knockout with collagen trafficking and Hedgehog readouts

    PMID:38183057 PMID:38852507

    Open questions at the time
    • UBA1 interaction not reconstituted with purified proteins
    • Lipid droplet localization mechanism (prenylation-dependent?) not defined
    • Whether collagen trafficking role is direct or secondary to Golgi integrity loss unclear

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key mechanistic questions remain: the identity of the Rab34 GAP, the direct effector mediating ciliary vesicle formation at the mother centriole, the structural basis of the N-terminal LPQ motif function, whether DENND6A activates Rab34 for ciliogenesis, and how Src-mediated Y247 phosphorylation intersects with ciliogenesis and lysosome positioning functions.
  • Rab34 GAP identity unknown
  • Direct ciliogenesis effector at the mother centriole not identified
  • No structural model of Rab34 in complex with any effector or regulator

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0098772 molecular function regulator activity 4 GO:0003924 GTPase activity 3
Localization
GO:0005794 Golgi apparatus 5 GO:0005764 lysosome 4 GO:0005815 microtubule organizing center 3 GO:0005929 cilium 3 GO:0031410 cytoplasmic vesicle 3 GO:0005886 plasma membrane 2 GO:0005811 lipid droplet 1
Pathway
R-HSA-5653656 Vesicle-mediated transport 4 R-HSA-162582 Signal Transduction 3 R-HSA-1852241 Organelle biogenesis and maintenance 3 R-HSA-1266738 Developmental Biology 2 R-HSA-168256 Immune System 2 R-HSA-9612973 Autophagy 1
Partners
DENND6AFLCNITGB3RILPSRCUBA1UNC13B

Evidence

Reading pass · 24 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2002 Rab34 is associated primarily with the Golgi apparatus, and expression of wild-type or GTP-restricted (but not GDP-restricted) Rab34 causes spatial redistribution of lysosomes from the periphery to the peri-Golgi region. This activity requires membrane association via prenylation and direct interaction with RILP (Rab-interacting lysosomal protein), dependent on Lys82 in the switch I region. Overexpression of wild-type and mutant Rab34 constructs, GST pull-down, direct binding assays, site-directed mutagenesis (K82), immunofluorescence microscopy Molecular biology of the cell High 12475955
2002 Rab34/Rah localizes to membrane ruffles and nascent macropinosomes (co-localizing with actin), has extremely low intrinsic GTPase activity in vitro but appreciable activity in vivo (suggesting a GAP), and promotes macropinosome formation downstream of Rac1 and WAVE2. Cloning and in vitro GTPase assay, fluorescence microscopy, dominant-negative and constitutively active mutant overexpression, PDGF/phorbol ester stimulation The Journal of biological chemistry High 12446704
2003 RILP interacts selectively with GTP-bound (wild-type and GTP-restricted) but not GDP-restricted Rab34, as demonstrated by yeast two-hybrid and GST pull-down. A 62-residue region (aa272-333) unique to RILP is necessary for regulating lysosomal morphology and for interaction with both Rab7 and Rab34. Yeast two-hybrid, GST pull-down, chimeric protein domain-transfer experiments, overexpression and morphological analysis Molecular biology of the cell High 14668488
2005 RILP, the shared effector of Rab7 and Rab34, is capable of self-interaction (homodimerization), as demonstrated by yeast two-hybrid and co-immunoprecipitation in HeLa cells. Yeast two-hybrid, co-immunoprecipitation in HeLa cells Biochemical and biophysical research communications Medium 15996637
2005 Hmunc13 (a diacylglycerol-binding protein) is an effector of GTP-bound Rab34 at the Golgi; interaction requires the MHD-2 domain of hmunc13 and is dependent on the GTP-bound state of Rab34 (Q111L mutant), identified by bacterial two-hybrid screen and confirmed by co-immunoprecipitation. Bacterial two-hybrid screen, co-immunoprecipitation, GST pull-down with GTP/GDP-loaded mutants, radioactive GTP overlay assay Traffic Medium 16138900
2005 GTP overlay assay confirms that wild-type and GTP-restricted Rab34 bind GTP in vitro; K82 in Rab34 is a key residue required for RILP interaction and for lysosome redistribution in cells. GTP overlay assay, GST pull-down, site-directed mutagenesis, mammalian cell overexpression Methods in enzymology High 16473629
2007 CVB (coxsackievirus B) entry across epithelial tight junctions requires Rab34 (and Rab5) activity; both occludin internalization into macropinosomes and CVB infection are blocked by dominant-negative Rab34, indicating Rab34 functions in macropinocytic viral entry. Dominant-negative Rab34 expression, siRNA depletion, endocytosis/infection assays in polarized epithelial cells, inhibitors of macropinocytosis Cell host & microbe High 18005733
2007 Rab34 localizes to the Golgi stack and functions in intra-Golgi transport (downstream of ER, upstream of trans-Golgi network exit); depletion by dominant-negative Rab34 or RNAi blocks VSVG-GFP transport from Golgi to plasma membrane without affecting ER-to-medial Golgi traffic, as shown by endoglycosidase H resistance assay and brefeldin A treatment. Immunoelectron microscopy, immunocytochemistry, RNAi knockdown, dominant-negative overexpression, VSVG-GFP trafficking assay, EndoH resistance assay, brefeldin A treatment Molecular biology of the cell High 17881736
2009 Rab34 and munc13-2 form a functional complex at the Golgi that mediates protein secretion; siRNA knockdown of either munc13-2 or Rab34 abolishes high glucose-induced VSVG-GFP secretion, and munc13-2 with deleted MHD2 cannot rescue, establishing a Rab34–munc13-2 axis in regulated secretion. siRNA knockdown, VSVG-GFP secretion assay, MHD2 deletion mutant transfection, fibronectin secretion measurement American journal of physiology. Cell physiology Medium 19641095
2012 Rab34 mediates phagolysosome biogenesis through recruitment of Munc13-2; Rab34 knockdown impairs lysosome-phagosome fusion independently of Rab7, and Rab34-mediated phagosome maturation is critical for mycobacterial killing. siRNA knockdown, overexpression of active Rab34, phagolysosome fusion assay, mycobacterial survival assay, co-localization studies Proceedings of the National Academy of Sciences of the United States of America High 23197834
2016 Folliculin (FLCN) promotes peri-nuclear lysosome clustering via its C-terminal DENN domain interacting directly with the Rab34 effector RILP; using purified recombinant proteins, FLCN-DENN does not act as a GEF for Rab34 but loads active Rab34 onto RILP to form a ternary complex, restricting lysosome motility under starvation. Purified recombinant protein binding assay, GEF assay, knockdown/overexpression, live-cell imaging, lysosome motility analysis EMBO reports High 27113757
2018 Rab34 localizes to cilia in vivo; Rab34 mutation in mice impairs preciliary vesicle fusion to form ciliary vesicles and blocks mother centriole migration to the plasma membrane, resulting in reduced ciliogenesis, polydactyly, cleft lip/palate, and failure of Hedgehog signaling (reduced Gli3 processing). Mouse knockout/mutation, immunofluorescence, electron microscopy, Gli3 processing assay, phenotypic analysis Journal of cell science High 30301781
2018 Rab34 binds to the cytoplasmic tail of integrin β3 and prevents its degradation; EGF induces translocation of Rab34 to membrane ruffles, enhanced by Src kinase; Src phosphorylates Rab34 at Y247, and a phosphomimetic mutant (Y247D) promotes cell migration, invasion, integrin β3 endocytosis, and recycling. Co-immunoprecipitation, shRNA knockdown, overexpression of phosphomimetic/phospho-dead mutants, EGF stimulation, in vitro kinase assay, cell migration/invasion assays Oncogene High 29622794
2020 A comprehensive siRNA screen identified Rab34 as essential for serum starvation-induced ciliogenesis in hTERT-RPE1, NIH/3T3, and MCF10A cells (but not MDCK-II cysts); a unique long N-terminal region (aa1-49) of Rab34, rather than the switch II region, is required for this function. Genome-wide siRNA knockdown screen (62 Rabs), Rab34 KO by CRISPR, deletion/mutation analysis, ciliogenesis assay The Journal of biological chemistry High 32669361
2021 Rab34 is specifically required for the intracellular (but not extracellular/surface) ciliogenesis pathway; it marks the ciliary sheath, a unique sub-domain of assembling intracellular cilia, and is required for ciliary vesicle formation at the mother centriole. GTP binding and turnover by Rab34 are both required for ciliogenesis, modulated by divergent residues in its GTPase domain. Rab34 KO in multiple cell lines, live-cell imaging, electron microscopy, GTPase activity assays, domain/residue mutagenesis, MDCK extracellular pathway comparison Current biology : CB High 33989527
2021 Proximity biotinylation with Ift27 as bait identified Rab34 as a ciliary protein; Rab34 localizes near the mother centriole and is required for ciliary vesicle formation at an early step. In fibroblasts (using internal ciliogenesis pathway), Rab34 loss blocks ciliogenesis; in epithelial IMCD3 cells at low density (using internal pathway), Rab34 is also required. Proximity biotinylation (BioID), Rab34 KO/knockdown, immunofluorescence, ciliogenesis assay across cell types and densities Current biology : CB High 33989524
2021 The N-terminal LPQ sequence (amino acids 16-18) of Rab34 is specifically required for ciliogenesis in hTERT-RPE1 cells; a Rab34 mutant with LPQ→AAA substitution fails to rescue the Rab34-KO ciliogenesis defect. Rab34 KO rescue assay, deletion analysis, site-directed mutagenesis (LPQ→AAA), ciliogenesis assay Small GTPases Medium 33860735
2023 Pathogenic bi-allelic missense variants in RAB34 clustered near the C-terminus cause oral-facial-digital syndrome (OFDS-RAB34) with loss of ciliogenesis function; cells expressing mutant RAB34 show significant defects in cilium assembly, with some variants retaining mother centriole recruitment but failing subsequent steps of intracellular ciliogenesis. Exome sequencing, patient-derived cell functional assays, ciliogenesis assay, immunofluorescence Human molecular genetics Medium 37384395
2024 DENND6A is a GEF for Rab34; activated by Arl8b on peripheral lysosomes, DENND6A activates Rab34, which then recruits a RILP/dynein complex to lysosomes to promote retrograde transport. Loss of DENND6A impairs autophagic flux, placing Arl8b→DENND6A→Rab34→RILP/dynein as a regulatory axis controlling nutrient-dependent juxtanuclear lysosome repositioning. Cell-based GEF screen, GEF activity assay, co-immunoprecipitation, pulldown with purified proteins, lysosome positioning assay, autophagic flux assay, epistasis experiments Nature communications High 38296963
2024 Rab34 regulates type I collagen trafficking from the ER to the Golgi and is required for Golgi cisternae integrity; in adipocytes, Rab34 translocates from the Golgi to lipid droplets during lipid droplet biogenesis, where it controls lipolysis through interaction with the E1-ubiquitin ligase UBA1, which ubiquitinates FABP5 for proteasomal degradation. At the Golgi, Rab34 regulates adiponectin trafficking and oligomerization. Immunofluorescence with organelle markers, siRNA knockdown, overexpression, proteomic interactome analysis, adiponectin secretion/oligomerization assay, lipolysis assay, co-immunoprecipitation Journal of biomedical science Medium 38183057
2024 Rab34 is required for cilia formation and cilia-mediated Hedgehog signaling in craniofacial development; it also has a non-ciliary function in regulating type I collagen trafficking from the ER to the Golgi, impacting osteogenesis. Mouse conditional knockout, immunofluorescence, Hedgehog signaling assays, collagen trafficking assay Biochemical and biophysical research communications Medium 38852507
2017 Salmonella effector SopD2 binds Rab34 and modulates its function; depletion of Rab34 delays maturation of the Salmonella-containing vacuole (SCV) and inhibits intracellular S. typhimurium growth, establishing Rab34 as a host factor required for SCV maturation. Co-immunoprecipitation, siRNA knockdown, intracellular bacterial growth assay, SCV maturation assay Cell biology international Medium 28185347
2023 PSMB1 (proteasome subunit beta type-1) binds directly to RAB34 and promotes its proteasome-dependent degradation, leading to inactivation of the MEK/ERK signaling pathway; Kinetin enhances the PSMB1-RAB34 interaction and accelerates RAB34 degradation. Co-immunoprecipitation, proteasome inhibitor assay, MEK/ERK phosphorylation western blot, PDX and liver metastasis xenograft models, computer-aided drug design Cancer letters Medium 38159835
2022 Rab34 acts as a negative regulator of osteoclast differentiation by promoting lysosomal proteolysis of osteoclastogenic surface receptors c-fms and RANK via the early endosome–late endosome–lysosome axis, thereby attenuating c-fos/NFATc1 transcriptional activity; Rab34 also modulates secretion of lysosomal proteases (MMP9, Cathepsin K) at ruffled borders. siRNA knockdown, overexpression, osteoclast differentiation assay (RAW-D cells and bone marrow-derived macrophages), receptor degradation assay, transcription factor activity assay Cell biochemistry and function Medium 35285960

Source papers

Stage 0 corpus · 47 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2007 Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5. Cell host & microbe 192 18005733
2002 Interorganellar regulation of lysosome positioning by the Golgi apparatus through Rab34 interaction with Rab-interacting lysosomal protein. Molecular biology of the cell 115 12475955
2002 Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. The Journal of biological chemistry 92 12446704
2016 Folliculin directs the formation of a Rab34-RILP complex to control the nutrient-dependent dynamic distribution of lysosomes. EMBO reports 79 27113757
2012 Size-dependent mechanism of cargo sorting during lysosome-phagosome fusion is controlled by Rab34. Proceedings of the National Academy of Sciences of the United States of America 57 23197834
2016 C9ORF72 is a GDP/GTP exchange factor for Rab8 and Rab39 and regulates autophagy. Small GTPases 54 27494456
2001 Maximal expression of membrane-bound nitrate reductase in Paracoccus is induced by nitrate via a third FNR-like regulator named NarR. Journal of bacteriology 53 11371524
2007 Golgi-bound Rab34 is a novel member of the secretory pathway. Molecular biology of the cell 48 17881736
2021 Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway. Current biology : CB 47 33989527
2003 A unique region of RILP distinguishes it from its related proteins in its regulation of lysosomal morphology and interaction with Rab7 and Rab34. Molecular biology of the cell 47 14668488
2010 Rab36 regulates the spatial distribution of late endosomes and lysosomes through a similar mechanism to Rab34. Molecular membrane biology 45 19961360
2003 Rab39, a novel Golgi-associated Rab GTPase from human dendritic cells involved in cellular endocytosis. Biochemical and biophysical research communications 40 12684051
2022 Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells. Cell reports 36 35649370
2018 Rab34 regulates adhesion, migration, and invasion of breast cancer cells. Oncogene 36 29622794
2004 Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity. The Journal of biological chemistry 35 14752093
2005 The Rab-interacting lysosomal protein, a Rab7 and Rab34 effector, is capable of self-interaction. Biochemical and biophysical research communications 31 15996637
2021 Rab34 is necessary for early stages of intracellular ciliogenesis. Current biology : CB 30 33989524
2018 Rab34 small GTPase is required for Hedgehog signaling and an early step of ciliary vesicle formation in mouse. Journal of cell science 26 30301781
2020 A comprehensive analysis of Rab GTPases reveals a role for Rab34 in serum starvation-induced primary ciliogenesis. The Journal of biological chemistry 23 32669361
2005 Diacylglycerol-activated Hmunc13 serves as an effector of the GTPase Rab34. Traffic (Copenhagen, Denmark) 21 16138900
2024 DENND6A links Arl8b to a Rab34/RILP/dynein complex, regulating lysosomal positioning and autophagy. Nature communications 17 38296963
2020 PVT1 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer via Regulating miR-148/RAB34 Signal Axis. OncoTargets and therapy 16 32184617
2023 Pathogenic RAB34 variants impair primary cilium assembly and cause a novel oral-facial-digital syndrome. Human molecular genetics 13 37384395
2017 Salmonella effector SopD2 interferes with Rab34 function. Cell biology international 13 28185347
2017 QPY/RAH haplotypes of the GZMB gene are associated with natural killer cell cytotoxicity. Immunogenetics 12 28653095
2005 Assay and functional properties of Rab34 interaction with RILP in lysosome morphogenesis. Methods in enzymology 12 16473629
2009 Rab34 and its effector munc13-2 constitute a new pathway modulating protein secretion in the cellular response to hyperglycemia. American journal of physiology. Cell physiology 11 19641095
2013 Spatial distribution of phagolysosomes is independent of the regulation of lysosome position by Rab34. The international journal of biochemistry & cell biology 8 23871933
2023 Discovery of Kinetin in inhibiting colorectal cancer progression via enhancing PSMB1-mediated RAB34 degradation. Cancer letters 7 38159835
2022 Rab34 plays a critical role as a bidirectional regulator of osteoclastogenesis. Cell biochemistry and function 6 35285960
2018 CSN6 and Rab34 Are Involved in Androgen Receptor Trafficking in Mouse Testicular Sertoli Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 6 29991022
2021 Drosophila Rab39 Attenuates Lysosomal Degradation. International journal of molecular sciences 5 34638976
2011 Identification and characterization of a novel ubiquitous nucleolar protein 'NARR' encoded by a gene overlapping the rab34 oncogene. Nucleic acids research 5 21586586
2005 Assays for functional properties of Rab34 in macropinosome formation. Methods in enzymology 5 16473590
2023 Compound heterozygous variants in RAB34 in a rare skeletal ciliopathy syndrome. Clinical genetics 4 37619988
2024 Localization, traffic and function of Rab34 in adipocyte lipid and endocrine functions. Journal of biomedical science 3 38183057
2024 Ciliary and non-ciliary functions of Rab34 during craniofacial bone development. Biochemical and biophysical research communications 3 38852507
2023 E2F1‑mediated RAB34 upregulation accelerates the proliferation and inhibits the cell cycle arrest and apoptosis of acute myeloid leukemia cells. Experimental and therapeutic medicine 3 37456160
2023 A Rab39-Klp98A-Rab35 endocytic recycling pathway is essential for rapid Golgi-dependent furrow ingression. Development (Cambridge, England) 3 37590130
2021 The N-terminal Leu-Pro-Gln sequence of Rab34 is required for ciliogenesis in hTERT-RPE1 cells. Small GTPases 3 33860735
2009 Rah, rah, ROS: metabolic changes caused by loss of adhesion induce cell death. Breast cancer research : BCR 3 19930622
2025 Soma-localized Rab39 inhibits synaptic autophagy by controlling trafficking of Atg9 vesicles. The EMBO journal 2 40841711
2025 The Rab7-Epg5 and Rab39-ema modules cooperatively position autophagosomes for efficient lysosomal fusions. eLife 1 41147582
1996 Preference in the nodulation of Phaseolus vulgaris cv. RAB39. II. Effect of delayed inoculation or low cell representation in the inoculant on nodule occupancy by Rhizobium tropici UMR1899. Canadian journal of microbiology 1 22049998
2026 miR-9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin. The Kaohsiung journal of medical sciences 0 41891636
2023 PVT1 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer via Regulating miR-148/RAB34 Signal Axis [Retraction]. OncoTargets and therapy 0 37551310
2012 Distribution of QPY and RAH haplotypes of granzyme B gene in distinct Brazilian populations. Revista da Sociedade Brasileira de Medicina Tropical 0 22767096