Affinage

Showing CAVIN1 — PTRF is a alias.

CAVIN1

Caveolae-associated protein 1 · UniProt Q6NZI2

Length
390 aa
Mass
43.5 kDa
Annotated
2026-06-09
100 papers in source corpus 44 papers cited in narrative 44 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 7/8 claims corpus-supported (88%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

CAVIN1 (PTRF) is a dual-function protein that originated as an RNA Polymerase I transcript release factor and is now established as an essential structural coat component of plasma membrane caveolae (PMID:9582279, PMID:18191225). At the membrane, CAVIN1 builds caveolae by forming a flexible polyhedral net-like 60S protein mesh on phosphatidylserine-containing bilayers, using two coiled-coil domains for distinct assembly steps and a PI(4,5)P2-dependent trimeric HR1 region that adsorbs to and inserts into the membrane (PMID:27834731, PMID:35696574). It is required for caveola formation and for sequestering mobile caveolin-1 into immobile caveolae, where it stabilizes caveolin-1 against lateral diffusion and lysosomal degradation post-translationally; loss of CAVIN1 in mice and humans abolishes caveolae, destabilizes all three caveolin isoforms, and causes lipodystrophy and muscle disease (PMID:18191225, PMID:18840361, PMID:19726876, PMID:20300641). Together with caveolin-1, CAVIN1 generates a distinct caveolar lipid nano-environment selective for specific headgroups and acyl chains (PMID:33496726). CAVIN1 scaffolds and regulates signaling at caveolae, including SOCS3-dependent inhibition of IL-6/STAT3 signaling, competition with BMPR2 for the caveolin-1 scaffolding domain to attenuate BMP/Smad signaling, and control of hERG channel dynamics that determines susceptibility to drug-induced long QT syndrome (PMID:29330478, PMID:38182755, PMID:38682330). Mechanosensory caveolar disassembly releases CAVIN1 to other compartments: osmotic stress drives it to the nucleus where it promotes rRNA transcription, recapitulating its founding role of dissociating paused Pol I ternary complexes via interactions with TTF-I, Pol I, and 3'-uridylate-containing pre-rRNA (PMID:9582279, PMID:10589839, PMID:11139612, PMID:35513070), while lipid peroxidation releases CAVIN1 to directly bind and promote degradation of NRF2, maintaining susceptibility to oxidative-stress-induced ferroptosis (PMID:36858041). Inherited CAVIN1 mutations that mislocalize the protein and disrupt its caveolin interaction cause a human disease with deficiency of caveolae and all caveolin isoforms in muscle (PMID:19726876). CAVIN1 activity and localization are regulated post-translationally by phosphorylation at Ser-36/40/365/366 and by direct ubiquitination by UBE2O (PMID:15242332, PMID:36443833).

Mechanistic history

Synthesis pass · year-by-year structured walk · 15 steps
  1. 1998 High

    Established the founding biochemical function of the protein: how paused RNA Pol I complexes are resolved to terminate transcription.

    Evidence Reconstituted in vitro termination assay with recombinant PTRF, RNA-binding assay with substrate mutagenesis, and PTRF–TTF-I/Pol I interaction assays

    PMID:10589839 PMID:9582279

    Open questions at the time
    • Did not address whether this nuclear function operates in vivo under physiological conditions
    • No structural basis for 3'-uridylate recognition
  2. 2001 High

    Showed transcript release is coupled to reinitiation and that PTRF activity is post-translationally tunable, framing it as a regulated factor rather than a constitutive one.

    Evidence Multiple-round vs single-round Pol I transcription assays in a PTRF-free reconstituted system; phosphorylation/charge heterogeneity analysis

    PMID:11139612

    Open questions at the time
    • Specific phosphorylation sites controlling transcriptional activity not mapped here
    • Kinases responsible unknown
  3. 2004 High

    Relocated the protein to a second compartment by identifying it as a major peripheral coat protein on the cytosolic face of caveolae, mapping its phosphosites and PEST/calpain cleavage features.

    Evidence Vectorial surface proteomics with MS, confocal immunofluorescence, and phosphopeptide mapping in human adipocytes

    PMID:15242332

    Open questions at the time
    • Did not establish whether caveolar association is required for caveola formation
    • Functional consequence of each phosphosite unresolved
  4. 2008 High

    Demonstrated CAVIN1 is necessary and sufficient for caveola formation and post-translationally stabilizes caveolin-1, defining its core structural role in vivo.

    Evidence FRAP, siRNA/morpholino knockdown, ectopic expression in PC3 cells, EM in mammalian cells and zebrafish; knockout mouse with metabolic phenotyping

    PMID:18191225 PMID:18840361

    Open questions at the time
    • Molecular mechanism of caveolin-1 stabilization not resolved at structural level
    • Link between metabolic phenotype and specific caveolar function unclear
  5. 2010 High

    Confirmed the structural role in humans, establishing CAVIN1 loss-of-function as a cause of human caveolae/caveolin deficiency.

    Evidence Patient muscle biopsy and fibroblast EM/AFM, co-IP, and rescue by reintroduction of full-length protein

    PMID:19726876 PMID:20300641

    Open questions at the time
    • Genotype–phenotype relationship across mutations not detailed
    • Tissue-specific consequences of caveola loss not fully mapped
  6. 2014 Medium

    Mapped the molecular determinants of compartmental targeting, showing an N-terminal leucine-zipper motif is necessary and sufficient for caveolar association versus nuclear localization.

    Evidence Deletion mutants, fusion-protein targeting to histone H2A, and cavin-1 KO MEF migration rescue assays

    PMID:25514038

    Open questions at the time
    • Signal controlling switch between nuclear and membrane pools in cells not defined
    • Single lab
  7. 2016 High

    Provided the structural model of the caveolar coat, showing how CAVIN1 60S complexes build a polyhedral lattice on phosphatidylserine vesicles using two functionally distinct coiled-coil domains.

    Evidence Electron cryotomography, liposome reconstitution with purified proteins, and coiled-coil mutagenesis

    PMID:27834731

    Open questions at the time
    • Stoichiometry with caveolin in intact caveolae not fully resolved
    • How the coat couples to membrane curvature generation in cells
  8. 2016 Medium

    Separated CAVIN1's nuclear transcriptional function from its caveolar role, showing it drives rDNA transcription during metabolic challenge by a caveola-independent mechanism.

    Evidence Cavin-1 KO mouse adipocytes, rRNA transcription assays, and PTM analysis under metabolic challenge

    PMID:27528195

    Open questions at the time
    • Which PTMs gate nuclear transcriptional activity not defined
    • Single lab
  9. 2018 High

    Defined CAVIN1 as a signaling scaffold, anchoring SOCS3 at the membrane to enable inhibition of IL-6/STAT3 signaling.

    Evidence Reciprocal co-IP, confocal imaging of SOCS3 localization, SOCS3 KO cells and STAT3 phosphorylation/cAMP assays

    PMID:29330478

    Open questions at the time
    • Whether scaffolding is caveolae-dependent not fully resolved
    • Structural basis of CAVIN1–SOCS3 interaction unknown
  10. 2021 High

    Showed CAVIN1 and caveolin-1 jointly sculpt a unique caveolar lipid nano-environment, linking the coat to membrane lipid organization.

    Evidence Quantitative nanoscale lipid mapping and MD simulations in genome-edited cells

    PMID:33496726

    Open questions at the time
    • Functional consequences of the lipid nano-environment for signaling not established here
  11. 2022 High

    Defined the biophysics of membrane insertion, showing PI(4,5)P2-dependent HR1 adsorption and helix insertion with flanking disordered regions accelerating assembly.

    Evidence Model membrane biophysics, MD simulations, and cellular co-assembly assays with HR1 mutants

    PMID:35696574

    Open questions at the time
    • How insertion is coupled to oligomeric lattice formation in vivo not fully resolved
  12. 2022 Medium

    Connected caveolar mechanics to gene expression, showing caveolae deformation by osmotic stress relocalizes CAVIN1 to the nucleus to promote rRNA transcription and influence RNA/stress-granule homeostasis.

    Evidence Osmotic stress, cavin-1 KO cells, immunofluorescence localization, cytosolic RNA and stress-granule imaging

    PMID:35513070

    Open questions at the time
    • Quantitative fraction of CAVIN1 mobilized to nucleus unclear
    • Single lab
  13. 2022 Medium

    Identified direct ubiquitination by UBE2O as a regulator of CAVIN1 levels, caveola formation, and CAVIN1 secretion in exosomes.

    Evidence Endogenous/exogenous IP, in vitro ubiquitination assay, and exosome isolation/characterization

    PMID:36443833

    Open questions at the time
    • Ubiquitination site(s) on CAVIN1 not mapped
    • Single lab
  14. 2023 High

    Established a mechanosensory oxidative-stress arm, showing lipid-peroxidation-driven caveolar disassembly releases CAVIN1 to directly bind and promote NRF2 degradation, controlling ferroptosis susceptibility.

    Evidence Quantitative whole-cell proteomics of genome-edited cells, CAVIN1–NRF2 co-IP, live caveolae-disassembly imaging, and Cavin1-null zebrafish wound/ferroptosis assays

    PMID:36858041

    Open questions at the time
    • Mechanism by which CAVIN1 promotes NRF2 degradation (E3 recruitment vs direct) not defined
    • Structural basis of CAVIN1–NRF2 interaction unknown
  15. 2024 High

    Linked CAVIN1 expression to clinically relevant ion-channel behavior, showing it controls hERG translocation and determines individual susceptibility to drug-induced long QT syndrome.

    Evidence Patient-specific iPSC-derived cardiomyocytes, IKr electrophysiology, siRNA knockdown and adenoviral overexpression with cellular fractionation across multiple hERG blockers

    PMID:38682330

    Open questions at the time
    • Whether CAVIN1 directly binds hERG or acts via caveolae not distinguished
    • In vivo arrhythmia consequences not tested here

Open questions

Synthesis pass · forward-looking unresolved questions
  • How a single protein partitions quantitatively among its caveolar structural pool, nuclear transcriptional pool, and cytoplasmic signaling pool — and which specific PTMs and stress signals dictate this partitioning — remains unresolved.
  • No structure of full-length CAVIN1 in any compartment
  • Functional phosphosites and ubiquitination sites incompletely mapped
  • Mechanism coupling caveolar disassembly to choice of nuclear vs cytoplasmic destination unknown

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0005198 structural molecule activity 4 GO:0008289 lipid binding 3 GO:0060090 molecular adaptor activity 3 GO:0098772 molecular function regulator activity 3 GO:0140110 transcription regulator activity 3 GO:0003723 RNA binding 2
Localization
GO:0005634 nucleus 3 GO:0005886 plasma membrane 3 GO:0005829 cytosol 2 GO:0005815 microtubule organizing center 1
Pathway
R-HSA-1852241 Organelle biogenesis and maintenance 4 R-HSA-162582 Signal Transduction 3 R-HSA-74160 Gene expression (Transcription) 3 R-HSA-1430728 Metabolism 2 R-HSA-8953897 Cellular responses to stimuli 2
Partners
BMPR2CAV1CAVIN3NRF2PAXILLINSOCS3TTF-IUBE2O
Complex memberships
caveolar coat (60S cavin complex)

Evidence

Reading pass · 44 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
1998 PTRF (Pol I and transcript release factor) is required for dissociation of paused ternary RNA Polymerase I transcription complexes: recombinant PTRF releases both Pol I and nascent transcripts from the template in vitro, interacts with TTF-I (transcription termination factor), interacts with Pol I, and binds specifically to transcripts containing 3'-terminal uridylates of pre-rRNA; substitution of 3'-terminal uridylates by guanine abolishes binding and impairs release activity. In vitro transcription termination assay with recombinant PTRF, RNA-binding assay, protein-protein interaction assays (PTRF–TTF-I and PTRF–Pol I) The EMBO journal High 9582279
1999 PTRF interacts physically with the largest subunit of murine RNA Pol I and with both TTF-I and its yeast homolog Reb1p (but not the lac repressor); PTRF promotes release of terminated transcripts from ternary complexes paused by TTF-I/Reb1p but cannot dissociate Pol I paused by the lac repressor, demonstrating specificity for termination-factor-mediated pausing. In vitro transcription assay on immobilized tailed templates with yeast and mouse terminators; protein interaction assays Molecular & general genetics High 10589839
2000 PTRF interacts with the BFCOL1 zinc-finger transcription factor (identified by yeast two-hybrid), enhances BFCOL1 binding to its site in the mouse proalpha2(I) collagen promoter in vitro, and has a suppressive effect on mouse proalpha2(I) collagen proximal promoter activity in transfection assays. Yeast two-hybrid, in vitro DNA-binding assay with recombinant proteins, transient transfection/promoter reporter assay The Biochemical journal Medium 10727401
2001 PTRF-mediated release of pre-rRNA from terminated transcription complexes facilitates reinitiation of RNA Pol I transcription (transcriptional enhancement observed on terminator-containing templates in multiple-round but not single-round assays, absent in PTRF-free reconstituted system); PTRF is phosphorylated at multiple sites and exists in transcriptionally active and inactive forms, suggesting its activity is regulated post-translationally. In vitro multiple-round vs. single-round Pol I transcription assays on terminator-containing and terminator-less templates; PTRF-free reconstituted system; charge heterogeneity/phosphorylation analysis Nucleic acids research High 11139612
2004 PTRF is a major peripheral protein at the cytosolic surface of caveolae in human adipocytes, co-localizes with caveolin-1 by immunofluorescence, is present in intact and five differently truncated forms at the caveolae surface, contains phosphorylation sites at Ser-36, Ser-40, Ser-365 and Ser-366, and is cleaved at two endogenous calpain-specificity sites flanked by phosphorylated sequences within PEST domains. Vectorial proteomics (trypsin-based differential surface proteolysis + nanospray-QTOF MS), immunofluorescence confocal microscopy, phosphopeptide mapping The Biochemical journal High 15242332
2008 PTRF/Cavin-1 is required for caveola formation and for sequestration of mobile caveolin into immobile caveolae at the plasma membrane: PTRF-Cavin selectively associates with mature caveolae (not Golgi-localized caveolin); expression of PTRF in PTRF-negative PC3 cells is sufficient to induce caveola formation; PTRF knockdown reduces caveolae density; without PTRF, caveolin-1 exhibits increased lateral mobility and accelerated lysosomal degradation. Comparative proteomics, live-cell fluorescence imaging (FRAP), knockdown (siRNA/morpholino) in mammalian cells and zebrafish, ectopic expression in PC3 cells, electron microscopy Cell High 18191225
2008 Genetic deletion of Cavin/PTRF in mice abolishes caveolae in all cell types examined and markedly reduces protein (but not mRNA) levels of all three caveolin isoforms, demonstrating that Cavin-1 is required post-translationally for caveolin stability; knockout mice develop lipodystrophy, dyslipidemia, and glucose intolerance. Targeted gene disruption (knockout mice), electron microscopy, western blot, qRT-PCR, metabolic phenotyping Cell metabolism High 18840361
2009 PTRF mutations in patients cause mislocalization of PTRF and disruption of its physical interaction with caveolins; patient muscle biopsies show deficiency and mislocalization of all three caveolin family members and reduction of caveolae structures, confirming PTRF's essential role in caveolin localization and caveola formation in humans. Patient muscle biopsy, immunofluorescence, co-immunoprecipitation (PTRF–caveolin interaction), overexpression of disease-mimicking mutants in myoblasts The Journal of clinical investigation High 19726876
2010 PTRF/Cavin-1 expression in PTRF-negative PC3 prostate cancer cells decreases cell migration via reduced MMP-9 production; this effect on MMP-9 is independent of caveola formation. Ectopic expression, cell migration assays, MMP-9 ELISA/zymography, comparison with cavin-2/3/4 European journal of cell biology Medium 20732728
2010 In the absence of PTRF-CAVIN, caveolin-1 fails to localize to the cell surface in patient fibroblasts (electron microscopy shows >97% reduction in caveolae); transfection of full-length PTRF-CAVIN reestablishes caveolae. Patient fibroblast analysis, electron microscopy, atomic force microscopy combined with fluorescence imaging, rescue transfection PLoS genetics High 20300641
2010 IGF-IR co-immunoprecipitates with PTRF/Cavin during IGF-1-induced receptor internalization; PTRF/Cavin silencing decreases IGF-IR plasma membrane recovery after internalization; Caveolin-1 phosphorylation at Tyr14 is required for normal IGF-IR internalization. Co-immunoprecipitation, siRNA knockdown, flow cytometry for surface IGF-IR, Cav-1 Y14F mutant transfection PloS one Medium 21152401
2011 PTRF acts as a docking/anchoring protein for MG53 at membrane injury sites, potentially through binding exposed membrane cholesterol; cells lacking PTRF show defective MG53 trafficking to injury sites; a disease-associated PTRF mutation causes aberrant nuclear localization of PTRF and disrupts MG53 function in membrane resealing; overexpression of PTRF rescues membrane repair defects in dystrophic muscle. Live-cell imaging of membrane repair, RNAi knockdown, ectopic expression, disease-mutant analysis, overexpression rescue in dystrophic muscle cells The Journal of biological chemistry Medium 21343302
2011 Oxidative stress upregulates PTRF/cavin-1 and promotes its interaction with caveolin-1, increasing caveolae number; PTRF/cavin-1 is required for oxidant-induced sequestration of Mdm2 into caveolar membranes away from p53, activating the p53/p21 pathway and inducing premature senescence; a PTRF mutant unable to localize to caveolar membranes after oxidative stress fails to activate p53 and does not induce senescence. shRNA knockdown, mutant PTRF (membrane-localization defective) expression, immunofluorescence, co-immunoprecipitation (PTRF–caveolin-1), p53/p21 pathway analysis, senescence assays The Journal of biological chemistry Medium 21705337
2011 PTRF localizes primarily to nuclei in young/quiescent fibroblasts but translocates to cytosol and plasma membrane during senescence; PTRF overexpression increases caveolae and induces cellular senescence; reduced PTRF extends replicative lifespan; PTRF's role in senescence depends on its interaction with caveolin-1 and targeting to caveolae, which is regulated by PTRF phosphorylation. Immunofluorescence, electron microscopy, overexpression, siRNA knockdown, replicative lifespan assay, co-immunoprecipitation (PTRF–caveolin-1), phosphorylation analysis Cell research Medium 21445100
2011 PTRF expression in PC3 cells impairs recruitment of actin cytoskeletal proteins to detergent-resistant membranes, correlating with altered cholesterol distribution; this reduces secretion of a subset of proteins including secreted proteases, cytokines, and growth regulatory proteins, partly via reduction in prostasome secretion; several proteins involved in ER-to-Golgi trafficking were reduced by PTRF. SILAC quantitative proteomics, subcellular fractionation (detergent-resistant membranes), total membrane proteomics, cholesterol modulation experiments Molecular & cellular proteomics Medium 22030351
2012 PTRF/cavin-1 modulates cellular polarization and the subcellular localization of Rac1, caveolin-1, and PKCα in migrating cells; PTRF quantitatively reduces cell migration and induces mesenchymal-epithelial reversion; caveola-independent functions of PTRF in cell migration were identified by selectively manipulating caveola formation in multiple cell systems. Fluorescence imaging, quantitative proteomics, cell migration assays, selective manipulation of PTRF and caveolin-1 expression in multiple cell lines PloS one Medium 22912783
2013 Cavin-1 expression in PC3 prostate cancer cells (which lack endogenous cavin-1) attenuates the pro-tumorigenic effects of non-caveolar caveolin-1 microdomains; cavin-1 co-expression in caveolin-1-positive LNCaP cells reverses the caveolin-1-mediated increase in anchorage-independent growth; these effects occur partly via reduced IL-6 microenvironmental signaling. Ectopic expression, anchorage-independent growth assay, orthotopic xenograft mouse model, IL-6 measurement, tissue microarray Oncogene Medium 23934189
2013 PTRF/cavin-1 is essential for multidrug resistance in breast cancer MCF-7/ADR cells: PTRF is upregulated in lipid rafts of drug-resistant cells; PTRF knockdown reduces lipid raft abundance at the cell surface and reduces multidrug resistance. Label-free quantitative proteomics of lipid rafts, lipid raft staining (S-laurdan2, FITC-CTxB), siRNA knockdown, drug resistance assays Journal of proteome research Medium 23214712
2014 Cavin-3 is targeted to caveolae by cavin-1 (PTRF), where it interacts with the scaffolding domain of caveolin-1 and promotes caveolae dynamics; the N-terminal region of cavin-3 binds a trimer of the cavin-1 N-terminus in competition with a homologous cavin-2 region, showing that cavins form distinct subcomplexes; cavin-3 loss increases stable caveolae and decreases short-lived caveolae. Live-cell imaging (caveolae dynamics), pulldown/interaction assays, cell-based localization, cavin-3 knockout/overexpression Journal of cell science Medium 25588833
2014 In cavin-1-null mice adipocytes, lipolytic defects are caused by impaired perilipin phosphorylation; reduced triglyceride accumulation results from decreased fatty acid uptake and incorporation and near absence of insulin-stimulated glucose transport; adipocytes are small and insensitive to insulin and β-adrenergic agonists. Cavin-1 knockout mice, metabolic phenotyping, insulin/β-adrenergic stimulation assays, perilipin phosphorylation analysis, glucose transport assay The Journal of biological chemistry High 24509860
2014 PTRF overexpression compromises adipocyte differentiation of 3T3-L1 cells; lentiviral PTRF overexpression inhibits adipogenesis; PTRF mRNA positively correlates with markers of lipolysis and cellular senescence in human adipose tissue. Lentiviral and pharmacological overexpression, 3T3-L1 differentiation assay, proteomics, human adipose tissue correlation FASEB journal Medium 24812087
2014 PTRF interacts with PDGF receptors (PDGFRs); this interaction is increased in senescent cells; PTRF overexpression in presenescent cells impairs ERK1/2 phosphorylation upon PDGF stimulation, suggesting PTRF sequesters PDGFRs and attenuates their signaling. Co-immunoprecipitation (PTRF–PDGFR), ERK1/2 phosphorylation assay, PTRF overexpression in young cells, comparison with senescent cells Clinical and experimental pharmacology & physiology Medium 24471649
2014 The N-terminal leucine-zipper motif of PTRF/cavin-1 is essential and sufficient for its association with caveolae at the plasma membrane; deletion of this motif causes exclusive nuclear localization; fusion of this motif to the nuclear protein histone 2A redirects it to the plasma membrane; caveolae-associated PTRF (not nuclear PTRF) is required for its role in cell migration. Deletion mutants, fusion protein targeting assay, cavin-1 knockout MEFs, cell migration rescue experiments Biochemical and biophysical research communications Medium 25514038
2016 Purified Cavin1 60S complexes form a flexible net-like protein mesh that creates polyhedral lattices on phosphatidylserine-containing vesicles; the two coiled-coil domains mediate distinct assembly steps in 60S complex formation; positively charged residues around the C-terminal coiled-coil domain are required for membrane binding; purified caveolin 8S oligomers form disc-shaped arrangements consistent with occupying the faces of caveolar polyhedra. Electron cryotomography, liposome reconstitution with purified proteins, coiled-coil domain mutagenesis, solution structural analysis Proceedings of the National Academy of Sciences of the United States of America High 27834731
2016 ROR1 functions as a scaffold for cavin-1 and caveolin-1 at the plasma membrane in a kinase-independent manner; ROR1 facilitates cavin-1–caveolin-1 interactions, preventing lysosomal degradation of CAV1 and sustaining caveolae structures and pro-survival AKT signaling. Co-immunoprecipitation (ROR1–cavin-1–CAV1 complex), kinase-dead ROR1 mutants, knockdown, caveolae structural analysis, AKT signaling readout Nature communications Medium 26725982
2016 PTRF/Cavin-1 promotes ribosomal RNA transcription in response to metabolic challenges in mature adipocytes via a caveolae-independent mechanism; multiple post-translational modifications of PTRF regulate its transcriptional activity; PTRF-mediated rDNA transcription is required for adipocyte allostasis. Cavin-1 knockout mouse adipocytes, rRNA transcription assays, PTM analysis, metabolic challenge experiments eLife Medium 27528195
2017 Cavin-1 is acutely translocated from caveolae to focal complex compartments upon insulin stimulation in adipocytes, where it regulates focal complex formation through an interaction with paxillin; loss of cavin-1 impairs focal complex remodeling and focal adhesion formation and causes a mechanical stress response with activation of pro-inflammatory and senescence/apoptosis pathways. Cavin-1 knockout mice, subcellular fractionation, immunoblotting, co-immunoprecipitation (cavin-1–paxillin), insulin stimulation experiments The Journal of biological chemistry Medium 31126986
2018 SOCS3 localizes to the plasma membrane via interaction with cavin-1; deletion of SOCS3 reduces cavin-1 and caveolin-1 protein expression and caveola abundance; cavin-1–SOCS3 interaction is essential for SOCS3-dependent inhibition of IL-6/STAT3 signaling; loss of cavin-1 enhances cytokine-stimulated STAT3 phosphorylation and abolishes SOCS3-mediated inhibition of IL-6 signaling by cyclic AMP. Co-immunoprecipitation, confocal imaging (SOCS3 localization), SOCS3 knockout cells, cytokine signaling assays (STAT3 phosphorylation), cAMP treatment Nature communications High 29330478
2019 High glucose suppresses CAV1-CAVIN1-LC3B-mediated autophagic degradation of CAV1 via inhibition of the AMPK-MTOR-PIK3C3 pathway, causing CAV1 accumulation and increased caveolae formation that facilitates LDL transcytosis across endothelial cells. siRNA knockdown of CAVIN1/CAV1, autophagy inhibitors/activators, LDL transcytosis assay, AMPK/mTOR/PI3K pathway inhibitors, immunofluorescence Autophagy Medium 31448673
2021 Caveolin-1 and cavin-1 individually sort distinct plasma membrane lipids; intact caveolae containing both proteins generate a unique lipid nano-environment with selectivities for both lipid headgroups and acyl chains, as determined by quantitative nanoscale lipid mapping and molecular dynamics simulations. Quantitative nanoscale lipid mapping (STED-FCS or equivalent), molecular dynamics simulations, genome-edited cells expressing/lacking CAV1 and cavin-1 The Journal of cell biology High 33496726
2021 PTRF stabilizes cPLA2 protein by decreasing its proteasome-mediated degradation, thereby increasing cPLA2 activity; this leads to phospholipid remodeling, altered endocytosis capacity, altered energy metabolism, and suppression of CD8+ tumor-infiltrating lymphocytes in glioblastoma. Co-immunoprecipitation, western blotting, proteasome inhibitor experiments, nontargeted metabolomics/lipidomics, in vivo xenograft and intracranial tumor models Neuro-oncology Medium 33140095
2022 PTRF/Cavin-1 acts as an RNA-binding protein; it interacts with lncRNA NEAT1 (identified by RIP-Seq and RIP assay), stabilizing NEAT1 mRNA; NEAT1 stabilization suppresses UBXN1 expression, activating NF-κB, which transcriptionally upregulates PD-L1; this PTRF-NEAT1-NF-κB-PD-L1 axis promotes immune evasion in glioblastoma. RIP-Seq, RIP assay, ChIP assay, qRT-PCR, co-immunoprecipitation, luciferase reporter (implied by PD-L1 transcription analysis), T cell cytotoxicity assay Frontiers in immunology Medium 35069587
2022 Membrane insertion of Cavin1 is mediated by PI(4,5)P2-dependent adsorption of the trimeric helical region 1 (HR1) followed by partial separation and membrane insertion of individual HR1 helices; the flanking negatively charged disordered regions enhance insertion kinetics and are important for co-assembly of Cavin1 with Caveolin1 in living cells. Model membrane biophysics (lipid bilayer experiments), biophysical dissection, molecular dynamics simulations, cell-based co-assembly assays with HR1 mutants Proceedings of the National Academy of Sciences of the United States of America High 35696574
2022 HIF-1α and STAT3 regulate PTRF expression by binding to its promoter in neuronal cells under ischemia-reperfusion conditions (shown by ChIP and luciferase assays); neuronal PTRF overexpression enhances cPLA2 activity and stability by decreasing proteasome-mediated degradation; the PTRF-cPLA2 axis promotes lipid peroxidation, autophagy, and ferroptosis in neurons. ChIP, luciferase assay, co-immunoprecipitation, lentiviral sgRNA/AAV-shRNA knockdown, in vivo cerebral I/R mouse model Theranostics Medium 35547748
2022 PTRF promotes TMZ efflux from glioblastoma cells through extracellular vesicles; PTRF knockdown decreases TMZ efflux via EVs and sensitizes GBM cells to TMZ. PTRF knockdown (siRNA), intracellular TMZ concentration measurement, EV isolation/characterization (TEM, NTA, WB), clone formation/CCK-8 assays, flow cytometry, PDX models Theranostics Medium 35673568
2022 UBE2O ubiquitinates PTRF/CAVIN1 directly (shown by ubiquitination assay and immunoprecipitation); UBE2O decreases caveolae formation and inhibits PTRF-dependent exosome secretion; CAVIN2/SDPR interacts with both UBE2O and PTRF and promotes PTRF expression in exosomes, but UBE2O inhibition of exosome-related PTRF secretion prevails even with SDPR present. Immunoprecipitation (endogenous and exogenous), ubiquitination assay, exosome isolation by ultracentrifugation, TEM/NTA/WB characterization of exosomes Cell communication and signaling Medium 36443833
2022 Caveolae deformation (osmotic stress) triggers relocalization of cavin-1 from the plasma membrane to the nucleus, where it promotes rRNA transcription; cavin-1 knockout cells show adaptive changes in cytosolic RNA levels and reduced ability to form stress granules, demonstrating a mechanistic link between caveolae integrity and global transcriptional/translational regulation. Osmotic stress experiments, cavin-1 knockout cell line, immunofluorescence (cavin-1 localization), cytosolic RNA measurement, stress granule/p-body imaging The Journal of biological chemistry Medium 35513070
2023 Oxidative stress triggers lipid peroxidation and caveolar disassembly, releasing CAVIN1 from caveolae; released CAVIN1 directly interacts with NRF2 and facilitates NRF2 degradation; CAVIN1-null cells show impaired negative regulation of NRF2, conferring resistance to lipid-peroxidation-induced ferroptosis; this mechanism operates in cultured cells and in vivo (Cavin1-null zebrafish). Quantitative whole-cell proteomics of genome-edited cells, co-immunoprecipitation (CAVIN1–NRF2), live-cell caveolae disassembly imaging, Cavin1-null zebrafish wound response, ferroptosis assays Developmental cell High 36858041
2024 CAVIN1 expression level determines interindividual susceptibility to drug-induced long QT syndrome by controlling hERG channel dynamics: sotalol treatment promotes translocation of hERG from the plasma membrane to cytoskeleton-associated fractions in a CAVIN1-dependent manner; CAVIN1 knockdown reduces caveolae and abrogates hERG translocation and IKr reduction; CAVIN1 overexpression in low-sensitivity cardiomyocytes confers high sensitivity to hERG blockers. Patient-specific iPSC-derived cardiomyocytes, electrophysiology (IKr measurement), siRNA knockdown, adenoviral CAVIN1 overexpression, cellular fractionation, imaging of hERG and caveolae Circulation High 38682330
2024 The Cavin-1/Caveolin-1 interaction attenuates BMP/Smad signaling: hypoxia enhances the CAV1/Cavin-1 interaction while reducing the CAV1/BMPR2 interaction and BMPR2 membrane localization in pulmonary artery endothelial cells; Cavin-1 competes with BMPR2 for binding to the CAV1 scaffolding domain, reducing Smad signal transduction; Cavin-1 knockdown is resistant to CAV1-induced pulmonary hypertension in vivo. Co-immunoprecipitation (CAV1–Cavin-1, CAV1–BMPR2), domain-binding assays (CAV1 scaffolding domain), Cavin-1 knockdown in PAECs, in vivo CAV1-induced pulmonary hypertension model Communications biology Medium 38182755
2020 Cavin-1 deficiency impairs fenestration in liver sinusoidal endothelial cells (LSECs) by inhibiting the RhoA-ROCK2-LIMK-Cofilin signaling pathway and suppressing cytoskeleton dynamics; reduced LSEC fenestrae impairs hepatic glycogen metabolism leading to lethal neonatal hypoglycemia in C57BL/6J mice; treatment with the F-actin depolymerization reagent latrunculin A rescues fenestration defects. Cavin-1 knockout mice (C57BL/6J), electron microscopy of LSEC fenestrae, RhoA-ROCK2-LIMK-Cofilin pathway analysis, latrunculin A rescue experiment, glycogen/glucose measurements Advanced science Medium 33042738
2017 Cavin-1 deficiency in mice causes muscular dystrophy characterized by constitutive Akt pathway activation, muscle hypertrophy with increased fiber size, fibrosis, impaired membrane integrity with compensatory activation of the dystrophin-glycoprotein complex, elevated muscle repair proteins, and decreased mitochondrial function and oxygen consumption. PTRF/cavin-1 null mice, exercise capacity testing, histology, western blot (Akt pathway activation, dystrophin-glycoprotein complex), mitochondrial function assays, myofiber composition analysis JCI insight Medium 28289716
2016 Cavin-1 downregulation in vascular smooth muscle cells after balloon injury is mediated by proteasomal (not lysosomal) degradation; cavin-1 inhibition promotes VSMC proliferation and migration via increased ERK phosphorylation and MMP-9 activity; cavin-1 regulates caveolin-1 expression via the lysosomal degradation pathway. In vivo carotid artery balloon injury model, shRNA knockdown in vivo, proteasome/lysosome inhibitors (MG132, chloroquine), ERK phosphorylation assay, MMP-9 activity, VSMC proliferation/migration assays Journal of the American Heart Association Medium 28751541
2022 Cavin-1 promotes M2 macrophage/microglia polarization via interaction with SOCS3; Cavin-1 and SOCS3 positively correlate during M2 polarization; Cavin-1 silencing suppresses STAT6/PPARγ pathway activation and anti-inflammatory factor release; SOCS3 overexpression reverses the inhibitory effect of Cavin-1 silencing on M2 polarization. Co-immunoprecipitation (Cavin-1–SOCS3), siRNA knockdown of Cavin-1, STAT6/PPARγ pathway analysis, RT-PCR of M2 markers Inflammation research Medium 35275225

Source papers

Stage 0 corpus · 100 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2008 PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. Cell 593 18191225
2009 Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy. The Journal of clinical investigation 303 19726876
2008 Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance. Cell metabolism 292 18840361
2010 Fatal cardiac arrhythmia and long-QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations. PLoS genetics 181 20300641
1998 Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes. The EMBO journal 128 9582279
2004 Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. The Biochemical journal 124 15242332
2018 The role of PTRF/Cavin1 as a biomarker in both glioma and serum exosomes. Theranostics 110 29556340
2010 Congenital generalized lipodystrophy, type 4 (CGL4) associated with myopathy due to novel PTRF mutations. American journal of medical genetics. Part A 102 20684003
2011 Polymerase transcriptase release factor (PTRF) anchors MG53 protein to cell injury site for initiation of membrane repair. The Journal of biological chemistry 92 21343302
2014 Cavin-1/PTRF alters prostate cancer cell-derived extracellular vesicle content and internalization to attenuate extracellular vesicle-mediated osteoclastogenesis and osteoblast proliferation. Journal of extracellular vesicles 88 25018864
2022 Neuronal STAT3/HIF-1α/PTRF axis-mediated bioenergetic disturbance exacerbates cerebral ischemia-reperfusion injury via PLA2G4A. Theranostics 87 35547748
2016 ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1. Nature communications 77 26725982
2016 Model for the architecture of caveolae based on a flexible, net-like assembly of Cavin1 and Caveolin discs. Proceedings of the National Academy of Sciences of the United States of America 75 27834731
2019 CAV1-CAVIN1-LC3B-mediated autophagy regulates high glucose-stimulated LDL transcytosis. Autophagy 72 31448673
2013 PTRF/cavin-1 neutralizes non-caveolar caveolin-1 microdomains in prostate cancer. Oncogene 65 23934189
2012 PTRF/cavin-1 and MIF proteins are identified as non-small cell lung cancer biomarkers by label-free proteomics. PloS one 65 22461895
2010 PTRF-cavin-1 expression decreases the migration of PC3 prostate cancer cells: role of matrix metalloprotease 9. European journal of cell biology 63 20732728
2011 Expression of PTRF in PC-3 Cells modulates cholesterol dynamics and the actin cytoskeleton impacting secretion pathways. Molecular & cellular proteomics : MCP 60 22030351
2011 Regulation of cellular senescence by the essential caveolar component PTRF/Cavin-1. Cell research 58 21445100
2021 PTRF/cavin-1 remodels phospholipid metabolism to promote tumor proliferation and suppress immune responses in glioblastoma by stabilizing cPLA2. Neuro-oncology 57 33140095
1999 Mechanism of transcription termination: PTRF interacts with the largest subunit of RNA polymerase I and dissociates paused transcription complexes from yeast and mouse. Molecular & general genetics : MGG 57 10589839
2014 Pleiotropic effects of cavin-1 deficiency on lipid metabolism. The Journal of biological chemistry 55 24509860
2021 Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae. The Journal of cell biology 53 33496726
2013 Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes. American journal of physiology. Endocrinology and metabolism 53 23941874
2012 Co-regulation of cell polarization and migration by caveolar proteins PTRF/Cavin-1 and caveolin-1. PloS one 52 22912783
2010 Changes in caveolae, caveolin, and polymerase 1 and transcript release factor (PTRF) expression in prostate cancer progression. The Prostate 52 20564315
2010 A Japanese child with asymptomatic elevation of serum creatine kinase shows PTRF-CAVIN mutation matching with congenital generalized lipodystrophy type 4. Molecular genetics and metabolism 51 20638880
2013 Caveola-forming proteins caveolin-1 and PTRF in prostate cancer. Nature reviews. Urology 49 23938946
2000 PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters. The Biochemical journal 49 10727401
2001 The transcript release factor PTRF augments ribosomal gene transcription by facilitating reinitiation of RNA polymerase I. Nucleic acids research 48 11139612
2013 PTRF/cavin-1 is essential for multidrug resistance in cancer cells. Journal of proteome research 47 23214712
2016 PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges. eLife 45 27528195
2015 Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae. Journal of cell science 45 25588833
2011 Polymerase I and transcript release factor (PTRF)/cavin-1 is a novel regulator of stress-induced premature senescence. The Journal of biological chemistry 43 21705337
2013 Novel PTRF mutation in a child with mild myopathy and very mild congenital lipodystrophy. BMC medical genetics 42 24024685
2010 IGF-IR internalizes with Caveolin-1 and PTRF/Cavin in HaCat cells. PloS one 40 21152401
2013 PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis. Oncotarget 39 24123650
2010 Quantitative proteomics of caveolin-1-regulated proteins: characterization of polymerase i and transcript release factor/CAVIN-1 IN endothelial cells. Molecular & cellular proteomics : MCP 38 20585024
2022 PTRF/Cavin-1 enhances chemo-resistance and promotes temozolomide efflux through extracellular vesicles in glioblastoma. Theranostics 35 35673568
2022 PTRF/Cavin-1 as a Novel RNA-Binding Protein Expedites the NF-κB/PD-L1 Axis by Stabilizing lncRNA NEAT1, Contributing to Tumorigenesis and Immune Evasion in Glioblastoma. Frontiers in immunology 33 35069587
2015 Cavin-1 and Caveolin-1 are both required to support cell proliferation, migration and anchorage-independent cell growth in rhabdomyosarcoma. Laboratory investigation; a journal of technical methods and pathology 33 25822667
2015 Novel nonsense mutation in the PTRF gene underlies congenital generalized lipodystrophy in a consanguineous Saudi family. European journal of medical genetics 31 25721873
2020 PTRF/CAVIN1, regulated by SHC1 through the EGFR pathway, is found in urine exosomes as a potential biomarker of ccRCC. Carcinogenesis 30 31605605
2016 PTRF/Cavin-1 Deficiency Causes Cardiac Dysfunction Accompanied by Cardiomyocyte Hypertrophy and Cardiac Fibrosis. PloS one 29 27612189
2014 Hypoxia inhibits Cavin-1 and Cavin-2 expression and down-regulates caveolae in adipocytes. Endocrinology 29 25521582
2015 Galectin-3 Overrides PTRF/Cavin-1 Reduction of PC3 Prostate Cancer Cell Migration. PloS one 28 25942420
2010 Caveolin-1 induces formation of membrane tubules that sense actomyosin tension and are inhibited by polymerase I and transcript release factor/cavin-1. Molecular biology of the cell 28 20427576
2023 Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2. Developmental cell 27 36858041
2018 Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nature communications 27 29330478
2008 PTRF triggers a cave in. Cell 27 18191216
2017 MiR-217 promotes cutaneous squamous cell carcinoma progression by targeting PTRF. American journal of translational research 26 28337292
2014 Arterial dysfunction but maintained systemic blood pressure in cavin-1-deficient mice. PloS one 26 24658465
2013 Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF. Physiological reports 26 24303100
2016 DNA methylation profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with caveolin-1. Cancer letters 25 27894957
2014 Polymerase I and transcript release factor (PTRF) regulates adipocyte differentiation and determines adipose tissue expandability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 25 24812087
2014 Cavin-1: caveolae-dependent signalling and cardiovascular disease. Biochemical Society transactions 24 24646232
2013 Cavin1; a regulator of lung function and macrophage phenotype. PloS one 24 23634221
2020 Lessons from cavin-1 deficiency. Biochemical Society transactions 23 31922193
2012 Impaired contractility and detrusor hypertrophy in cavin-1-deficient mice. European journal of pharmacology 23 22643325
2023 Non-alcoholic fatty liver disease combined with rheumatoid arthritis exacerbates liver fibrosis by stimulating co-localization of PTRF and TLR4 in rats. Frontiers in pharmacology 22 37346294
2017 Cavin-1 regulates caveolae-mediated LDL transcytosis: crosstalk in an AMPK/eNOS/ NF-κB/Sp1 loop. Oncotarget 22 29262615
2017 MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer. Oncology reports 21 28393200
2015 Caveolae, caveolin-1 and cavin-1: Emerging roles in pulmonary hypertension. World journal of respirology 21 28529892
2014 Emerging role of polymerase-1 and transcript release factor (PTRF/ Cavin-1) in health and disease. Cell and tissue research 21 25107607
2023 PTRF-IL33-ZBP1 signaling mediating macrophage necroptosis contributes to HDM-induced airway inflammation. Cell death & disease 20 37454215
2023 Neovascularization directed by CAVIN1/CCBE1/VEGFC confers TMZ-resistance in glioblastoma. Cancer letters 18 38092144
2019 Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1. Journal of neuro-oncology 18 30949900
2022 Membrane insertion mechanism of the caveola coat protein Cavin1. Proceedings of the National Academy of Sciences of the United States of America 17 35696574
2022 UBE2O ubiquitinates PTRF/CAVIN1 and inhibits the secretion of exosome-related PTRF/CAVIN1. Cell communication and signaling : CCS 17 36443833
2020 Homotrimer cavin1 interacts with caveolin1 to facilitate tumor growth and activate microglia through extracellular vesicles in glioma. Theranostics 16 32550897
2019 Postmortem Findings in a Young Man With Congenital Generalized Lipodystrophy, Type 4 Due to CAVIN1 Mutations. The Journal of clinical endocrinology and metabolism 16 30476128
2017 Cavin-1 deficiency modifies myocardial and coronary function, stretch responses and ischaemic tolerance: roles of NOS over-activity. Basic research in cardiology 16 28343262
2016 Knockdown of PTRF ameliorates adipocyte differentiation and functionality of human mesenchymal stem cells. American journal of physiology. Cell physiology 16 27856429
2023 A new mutation in the CAVIN1/PTRF gene in two siblings with congenital generalized lipodystrophy type 4: case reports and review of the literature. Frontiers in endocrinology 15 37501786
2017 PTRF suppresses the progression of colorectal cancers. Oncotarget 15 27203393
2017 Muscular dystrophy in PTFR/cavin-1 null mice. JCI insight 15 28289716
2016 Maladaptative Autophagy Impairs Adipose Function in Congenital Generalized Lipodystrophy due to Cavin-1 Deficiency. The Journal of clinical endocrinology and metabolism 15 27144934
2016 Caveolin-1, Caveolin-2 and Cavin-1 are strong predictors of adipogenic differentiation in human tumors and cell lines of liposarcoma. European journal of cell biology 15 27168348
2023 Serum amyloid A and interleukin -1β facilitate LDL transcytosis across endothelial cells and atherosclerosis via NF-κB/caveolin-1/cavin-1 pathway. Atherosclerosis 13 36935311
2024 EPIC-1042 as a potent PTRF/Cavin1-caveolin-1 interaction inhibitor to induce PARP1 autophagic degradation and suppress temozolomide efflux for glioblastoma. Neuro-oncology 12 37651725
2014 Increased polymerase I and transcript release factor (Cavin-1) expression attenuates platelet-derived growth factor receptor signalling in senescent human fibroblasts. Clinical and experimental pharmacology & physiology 12 24471649
2020 A role for caveola-forming proteins caveolin-1 and CAVIN1 in the pro-invasive response of glioblastoma to osmotic and hydrostatic pressure. Journal of cellular and molecular medicine 11 32065471
2019 Metreleptin treatment for congenital generalized lipodystrophy type 4 (CGL4): a case report. Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology 11 30745727
2014 The N-terminal leucine-zipper motif in PTRF/cavin-1 is essential and sufficient for its caveolae-association. Biochemical and biophysical research communications 11 25514038
2011 A study of FHL1, BAG3, MATR3, PTRF and TCAP in Australian muscular dystrophy patients. Neuromuscular disorders : NMD 11 21683594
2017 Downregulation of Cavin-1 Expression via Increasing Caveolin-1 Degradation Prompts the Proliferation and Migration of Vascular Smooth Muscle Cells in Balloon Injury-Induced Neointimal Hyperplasia. Journal of the American Heart Association 10 28751541
2024 The Cavin-1/Caveolin-1 interaction attenuates BMP/Smad signaling in pulmonary hypertension by interfering with BMPR2/Caveolin-1 binding. Communications biology 9 38182755
2022 Cavin-1 promotes M2 macrophages/microglia polarization via SOCS3. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 9 35275225
2021 Suppression of PTRF Alleviates Post-Infectious Irritable Bowel Syndrome via Downregulation of the TLR4 Pathway in Rats. Frontiers in pharmacology 9 34690766
2019 Cavin-1/PTRF mediates insulin-dependent focal adhesion remodeling and ameliorates high-fat diet-induced inflammatory responses in mice. The Journal of biological chemistry 9 31126986
2023 Defected lipid rafts suppress cavin1-dependent IFN-α signaling endosome in paroxysmal nocturnal hemoglobinuria. International immunopharmacology 8 36608443
2020 Cavin1 Deficiency Causes Disorder of Hepatic Glycogen Metabolism and Neonatal Death by Impacting Fenestrations in Liver Sinusoidal Endothelial Cells. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8 33042738
2019 PTRF independently predicts progression and survival in multiracial upper tract urothelial carcinoma following radical nephroureterectomy. Urologic oncology 8 31862213
2023 Cavin1 activates the Wnt/β-catenin pathway to influence the proliferation and migration of hepatocellular carcinoma. Annals of hepatology 7 37774837
2022 Deformation of caveolae impacts global transcription and translation processes through relocalization of cavin-1. The Journal of biological chemistry 7 35513070
2021 Deficiency of cold-inducible RNA-binding protein exacerbated monocrotaline-induced pulmonary artery hypertension through Caveolin1 and CAVIN1. Journal of cellular and molecular medicine 7 33755319
2020 Unusual clinical features associated with congenital generalized lipodystrophy type 4 in a patient with a novel E211X CAVIN1 gene variant. Clinical diabetes and endocrinology 7 32467771
2024 CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT. Circulation 5 38682330
2018 Ptrf transgenic mice exhibit obesity and fatty liver. Clinical and experimental pharmacology & physiology 5 29381831
2025 PTRF Confers Melanoma-Acquired Drug Resistance Through the Upregulation of EGFR. Cell proliferation 4 40745979

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