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Showing GABPA — NRF2 is a alias.

GABPA

GA-binding protein alpha chain · UniProt Q06546

Length
454 aa
Mass
51.3 kDa
Annotated
2026-06-09
39 papers in source corpus 24 papers cited in narrative 23 extracted findings
Cross-family judge vs UniProt: Affinage preferred faithfulness: 6/6 claims corpus-supported (100%)

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

GABPA is an ETS-family DNA-binding transcription factor that binds ETS consensus motifs—preferentially closely spaced inverted ETS sites at bidirectional promoters—to activate transcription of a broad target program (PMID:8543189, PMID:7590737, PMID:24481480). It functions as a master specifier of developmental and lineage programs: a rapid-degradation system established its requirement for major zygotic genome activation and epiblast specification, where it occupies ICM gene promoters co-bound by TFAP2C and SOX2 to drive the naive pluripotency program (PMID:39747581). Across multiple epithelial cancers GABPA predominantly acts as a tumor suppressor by enforcing differentiation and restraining invasion: it directly activates DICER1 to limit cellular invasiveness, with re-expression of DICER1 rescuing the invasive phenotype of GABPA-depleted cells (PMID:30181547, PMID:32163919), and extends this through a DICER1→miR-30e→P4HA2 axis that lowers collagen deposition and ECM stiffness, suppresses YAP1 nuclear translocation, and restrains bladder cancer aggressiveness (PMID:40813762). It also activates the luminal-identity transcription factors FoxA1 and GATA3 in urothelial cells (PMID:31802036) and the TGFBR2 receptor to govern TGFβ signaling in renal carcinoma, an axis silenced by L-2HG-driven GABPA promoter methylation (PMID:35549739). In a context-specific role distinct from its tumor-suppressive function, GABPA mediates BRAF/MAPK-driven TERT reactivation by selectively recruiting activated ERK to mutant TERT promoters, where ERK phosphorylates Sp1 to open chromatin and reinforce GABPA binding (PMID:33483600). Its transcriptional output is shaped by cofactors including METTL23 (PMID:24501276) and the ERRα/CAPER nutrient-sensing axis that couples GABPA expression to mitochondrial energy metabolism (PMID:25830341), and it acts as a mitotic bookmarking factor cooperating with histone acetylation to regulate transcription across the M/G1 transition (PMID:30836589).

Mechanistic history

Synthesis pass · year-by-year structured walk · 9 steps
  1. 1995 Medium

    Establishing GABPA's genomic identity and biochemical class was the foundation: it was mapped to chromosome 21 and defined as an ETS-related DNA-binding protein that acts in heterodimeric complexes.

    Evidence Genomic Southern hybridization, exon sequencing, and FISH mapping, independently confirmed across two labs

    PMID:7590737 PMID:8543189

    Open questions at the time
    • Does not establish functional targets or transcriptional output
    • Heterodimer partners not characterized in this corpus
  2. 2012 Medium

    Genome-wide cistrome mapping showed GABPA regulates a gene network distinct from other ETS factors (ELK1), assigning it a specific role in cell migration via direct targets RAC1 and KIF20A.

    Evidence ChIP-seq with gene knockdown and migration assays in MCF10A breast epithelial cells

    PMID:23284628

    Open questions at the time
    • Mechanism of target selectivity vs. other ETS factors not resolved
    • Functional contribution of individual targets beyond RAC1/KIF20A unquantified
  3. 2014 Low

    Two findings refined the binding logic and cofactor dependence: GABPA preferentially binds promoters with closely spaced inverted ETS motifs, and METTL23 was identified as a physical co-regulator of its transcriptional activity.

    Evidence ChIP-seq motif-spacing analysis; co-immunoprecipitation plus reciprocal overexpression/knockdown at THPO and ATP5B target promoters

    PMID:24481480 PMID:24501276

    Open questions at the time
    • p53 R273H co-localization is binding correlation only, no functional validation
    • Whether METTL23 methylates GABPA directly is not established
  4. 2015 Medium

    Upstream regulation of GABPA itself was linked to metabolism: ERRα/CAPER coactivate Gabpa transcription in response to glucose, coupling nutrient signaling to GABPA-driven mitochondrial programs.

    Evidence Coactivation assays, CAPER siRNA, metabolic measurements, and transcriptomics

    PMID:25830341

    Open questions at the time
    • Direct mitochondrial target genes of GABPA in this context not enumerated
    • Single-lab finding without independent replication
  5. 2018 High

    The GABPA–DICER1 axis defined a concrete tumor-suppressive mechanism: GABPA directly activates DICER1 to restrain invasion, with DICER1 re-expression rescuing the phenotype.

    Evidence siRNA knockdown, promoter binding-site mutagenesis, rescue experiment, and patient/TCGA correlation in thyroid carcinoma

    PMID:30181547

    Open questions at the time
    • Downstream miRNA effectors not identified at this stage
    • Generality beyond thyroid carcinoma untested here
  6. 2019 Medium

    Three findings broadened GABPA's role into differentiation control and cell-cycle regulation: it directly activates luminal identity factors FoxA1/GATA3 in bladder cancer, contributes to vitamin-D receptor target regulation, and acts as a mitotic bookmarking factor cooperating with histone acetylation.

    Evidence ChIP and xenograft for FoxA1/GATA3; GABPA/VDR ChIP-seq cistrome overlap in monocytes; mitotic ChIP with histone modification and M/G1 transcription analysis

    PMID:28870774 PMID:30836589 PMID:31802036

    Open questions at the time
    • Mechanism of GABPA retention on mitotic chromatin unresolved
    • VDR co-localization is binding-based without functional rescue
  7. 2021 Medium

    A context-specific oncogenic role emerged: GABPA mediates MAPK-driven TERT reactivation by recruiting activated ERK to mutant TERT promoters, where ERK-phosphorylated Sp1 opens chromatin and reinforces GABPA binding.

    Evidence Reporter assays, ChIP, co-IP, and phosphorylation analysis in a single lab

    PMID:33483600

    Open questions at the time
    • No independent replication of the GABPA–ERK–Sp1 loop
    • Reconciliation of this oncogenic role with GABPA's tumor-suppressive functions not addressed
  8. 2022 High

    The TGFBR2 axis extended GABPA's tumor-suppressor mechanism and connected it to oncometabolite signaling: GABPA activates TGFBR2 to govern TGFβ signaling, and L-2HG silences GABPA via promoter methylation.

    Evidence RNA-seq, ChIP, xenograft, and L-2HG/methylation analysis in clear cell renal cell carcinoma

    PMID:35549739

    Open questions at the time
    • Other targets (RACGAP1, HPN-AS1) rest on lower-confidence single-assay evidence
    • How L-2HG directs methylation to the GABPA locus is unspecified
  9. 2025 Medium

    Degron-based studies placed GABPA at the top of early developmental hierarchies—required for zygotic genome activation and naive epiblast specification—and as required for T-lineage entry, while the DICER1 axis was mechanistically completed via miR-30e→P4HA2 control of ECM stiffness.

    Evidence Auxin-inducible degron with chromatin dynamics and single-cell transcriptomics (pluripotency); acute CRISPR KO in T-cell differentiation (preprint); transgenic mice and atomic force microscopy (ECM axis)

    PMID:39747581 PMID:39759007 PMID:40813762

    Open questions at the time
    • T-lineage requirement is preprint-level without downstream pathway placement
    • Whether developmental and tumor-suppressive functions share the same target logic is unknown

Open questions

Synthesis pass · forward-looking unresolved questions
  • How GABPA's opposing roles—tumor suppression via differentiation versus oncogenic TERT activation—are selected within a given cell, and what determines its locus-specific recruitment, remains unresolved.
  • No unifying model reconciling tumor-suppressive and oncogenic contexts
  • Determinants of context-specific cofactor recruitment (ERK/Sp1 vs. TFAP2C/SOX2) undefined
  • Structural basis of inverted-ETS-motif preference not established

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0140110 transcription regulator activity 5 GO:0003677 DNA binding 2
Localization
GO:0005634 nucleus 2
Pathway
R-HSA-74160 Gene expression (Transcription) 4 R-HSA-1643685 Disease 3 R-HSA-1266738 Developmental Biology 2
Partners
ERKMETTL23SOX2SP1TFAP2C

Evidence

Reading pass · 23 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2018 GABPA directly activates DICER1 transcription by binding to the DICER1 promoter; mutation of the GABPA binding site in the DICER1 promoter diminished basal DICER1 promoter activity and abolished GABPA-stimulated promoter activity. GABPA depletion reduced DICER1 expression and increased cellular invasion in thyroid carcinoma cells, while forced DICER1 expression rescued the invasive phenotype of GABPA-depleted cells. siRNA knockdown, GABPA binding site mutagenesis in promoter-reporter assay, forced DICER1 re-expression rescue experiment, correlation analysis in patient samples Oncogene High 30181547
2020 GABPA binds to the DICER1 promoter and regulates DICER1 expression in follicular thyroid carcinoma (FTC) cells; GABPA depletion reduced DICER1 expression, stimulated cell proliferation, and altered miRNA expression, confirming a direct transcriptional regulatory link. ChIP assay, siRNA knockdown of GABPA in FTC cell lines, miRNA expression profiling Endocrine-related cancer High 32163919
2019 GABPA directly activates transcription of FoxA1 and GATA3, key transcription factors driving luminal differentiation of urothelial cells, thereby dictating luminal identity in bladder cancer cells and suppressing aggressive/basal phenotypes, stemness, invasiveness, and cisplatin resistance. siRNA/shRNA knockdown and overexpression of GABPA, ChIP-based identification of FoxA1 and GATA3 as direct targets, xenograft transplant model for in vivo metastasis, TCGA/GEO dataset analyses Cell death and differentiation High 31802036
2022 GABPA directly activates TGFBR2 transcription (identified by RNA-seq and ChIP); GABPA and TGFBR2 phenocopy each other in clear cell renal cell carcinoma (ccRCC) cells, governing TGFβ signaling to suppress proliferation, invasion, and stemness. The oncometabolite L-2-hydroxyglutarate (L-2HG) silences GABPA expression by increasing GABPA gene methylation, thereby disrupting the GABPA–TGFβ axis. RNA sequencing, ChIP assay, siRNA knockdown and overexpression, xenograft mouse model, L-2HG treatment with methylation analysis, immunohistochemistry on patient specimens Journal of experimental & clinical cancer research High 35549739
2021 GABPA mediates regulation of BRAFV600E/MAPK signaling on TERT reactivation by selectively recruiting activated ERK to the mutant TERT promoter, where ERK phosphorylates Sp1, causing HDAC1 dissociation and active chromatin. Phosphorylated Sp1 further enhances GABPA binding to the mutant TERT promoter, establishing a synergistic activation loop. Reporter assays, ChIP assays, co-immunoprecipitation, overexpression/knockdown, phosphorylation analysis NPJ precision oncology Medium 33483600
2014 METTL23 physically interacts with GABPA (co-immunoprecipitation). Overexpression of METTL23 increased transcriptional activity at the THPO promoter (a GABPA target), while siRNA knockdown of METTL23 decreased expression of ATP5B (another GABPA target), establishing METTL23 as a co-regulator of GABPA transcriptional function. Co-immunoprecipitation, promoter-reporter assay for THPO, siRNA knockdown of METTL23 with qRT-PCR for ATP5B Human molecular genetics Medium 24501276
2012 GABPA controls cell migration in MCF10A breast epithelial cells by regulating a gene network distinct from that of ELK1. Direct GABPA targets RAC1 and KIF20A were identified as functionally important for this migration control. Chromatin immunoprecipitation-sequencing, gene knockdown, cell migration assays in breast epithelial cells PloS one Medium 23284628
2015 CAPER coactivates ERR-α-mediated Gabpa transcription in response to nutrient (glucose) signaling, linking nutrient-induced mitochondrial energy metabolism to GABPA expression. Inhibition of CAPER arrests ATP generation and GABPA-dependent mitochondrial transcriptional programs. Coactivation assays, siRNA inhibition of CAPER, metabolic measurements (ATP, respiration), transcriptome analysis PLoS genetics Medium 25830341
2017 The GABPA cistrome in THP-1 monocytes (3822 loci) overlaps significantly with VDR binding sites; ~23% of persistent VDR binding sites co-localize with GABPA. About 40% of GABPA binding sites are at transcription start sites, including ~100 of 1,25(OH)2D3 target genes, indicating GABPA contributes to differential vitamin D receptor target gene regulation. ChIP-sequencing of GABPA and VDR cistromes in THP-1 monocytes, bioinformatic co-localization analysis with PU.1 The Journal of steroid biochemistry and molecular biology Medium 28870774
2016 GABPA binds to human-specific promoter sequences to regulate transcription of ~1,215 candidate primary target genes; substitutions creating or disrupting GABPA consensus binding sequences functionally alter promoter activity both in human and nonhuman primate cell backgrounds, demonstrated by promoter-reporter assays and GABPA knockdown. ChIP-sequencing, promoter-reporter assays in human and African green monkey cells, GABPA knockdown followed by expression profiling Molecular biology and evolution Medium 26814189
2019 GABPA remains bound to specific genomic sites during mitosis and cooperates with histone acetylation marks (H3K9/14Ac, H3K27Ac, H4K5Ac) to act as a mitotic bookmarking factor. Depletion of GABPA increases H4K5Ac levels at target gene regions and induces transcriptional activation in early G1, suggesting GABPA negatively regulates transcription during the M/G1 transition. ChIP in mitotic cells, GABPA depletion with histone modification analysis, transcription assays at M/G1 transition International journal of molecular sciences Medium 30836589
2014 Gain-of-function mutant p53 (R273H) co-localizes genomically with GABPA binding sites at bidirectional promoters enriched for closely spaced ETS motifs. GABPA shows increased binding signal with higher numbers of ETS motifs per promoter and prefers promoters with closely spaced inverted ETS motifs, in contrast to ETS1. ChIP-seq for p53 R273H, ETS1, and GABPA; bioinformatic analysis of ETS motif spacing and binding signal Oncotarget Low 24481480
2022 GABPA binds directly to the RACGAP1 promoter and regulates its transcription in hepatocellular carcinoma, as confirmed by luciferase reporter and ChIP assays. Luciferase reporter assay, ChIP assay Oxidative medicine and cellular longevity Low 35958019
2022 GABPA negatively regulates GPX1 transcription in gastric cancer cells; GABPA binds GPX1 via a predicted site confirmed by dual-luciferase reporter assay, and overexpression of GABPA reduces GPX1 levels and blocks cell migration. Dual-luciferase reporter assay, GABPA overexpression, transwell and wound healing migration assays Journal of medical biochemistry Low 36042907
2023 GABPA binds directly to the PHB2 promoter region and controls transcriptional expression of PHB2 in endometriosis. PHB2 downregulation in ectopic endometrium leads to impaired PRKN/Parkin-mediated mitophagy, promoting cell proliferation, migration, and invasion. Bioinformatics, ChIP assay, reporter assay for GABPA-PHB2 promoter interaction, PHB2 overexpression/knockdown with mitophagy marker analysis Reproductive sciences Low 37587393
2024 GABPA directly binds to the ACSL4 promoter region and promotes ACSL4 transcription, increasing susceptibility of clear cell renal cell carcinoma cells to ferroptosis; GABPA overexpression suppressed ccRCC cell proliferation, migration, and invasion through this pathway. ChIP assay, GABPA overexpression in vitro and in vivo, ferroptosis assays Scientific reports Low 39489850
2024 GABPA functions as a transcription factor for HPN-AS1 (a lncRNA) by binding its promoter, as confirmed by ChIP and luciferase reporter assays in hepatocellular carcinoma cells. ChIP assay, luciferase reporter assay The Turkish journal of gastroenterology Low 39114737
2025 GABPA induces miR-30e expression by stimulating DICER1 transcription; higher miR-30e levels consequently target P4HA2 for downregulation. This GABPA→DICER1→miR-30e→P4HA2 axis reduces collagen I and III formation (ECM deposition), lowers ECM stiffness, suppresses YAP1 nuclear translocation (mechanotransduction), and restrains bladder cancer aggressiveness in xenograft models. GABPA-transgenic mice, GABPA overexpression/depletion in BC cells, atomic force microscopy of ECM rigidity, xenograft metastasis model, miR-30e manipulation, P4HA2 overexpression rescue Cell death & disease Medium 40813762
2025 GABPA regulates ASC transcription (confirmed by luciferase reporter and ChIP assays); HMGB1 activates caspase-1 through this GABPA-regulated ASC transcription in hepatic stellate cells, promoting liver fibrosis. Luciferase reporter assay, ChIP assay, immunofluorescence, immunoblotting, lentiviral transfection, caspase-1 inhibitor (Z-YVAD-FMK) treatment Biochimica et biophysica acta. Molecular cell research Low 40749747
2025 GABPA is required for T-lineage entry in early T cell development; acute CRISPR knockout of Gabpa blocks T-lineage developmental progression in an in vitro differentiation system derived from expanded hematopoietic progenitors. Acute CRISPR knockout of Gabpa in hematopoietic progenitor expansion + T cell differentiation culture system, single-cell RNA sequencing bioRxivpreprint Low bio_10.1101_2025.04.22.649893
2025 GABPA is required for naive pluripotency establishment; using a targeted rapid protein degradation system, GABPA depletion disrupted major zygotic genome activation (ZGA) and epiblast (EPI) specification during E3.5–E4.5 transition, affecting 47% of EPI genes. GABPA binding dynamics show it occupies ICM gene promoters co-bound by TFAP2C and SOX2 at E3.5 to drive the EPI program at E4.5. Targeted rapid protein degradation (auxin-inducible degron system), chromatin binding dynamics analysis (ChIP/ATAC), single-cell transcriptomics Nature cell biology Medium 39747581
2024 miR-450b-5p directly targets GABPA (reducing its expression), and GABPA in turn binds directly to the HOXD10 promoter to regulate HOXD10 transcription. Knockdown of GABPA promoted proliferation and invasion of endometriotic cells in vivo and in vitro, phenocopying miR-450b-5p overexpression. miRNA target validation, GABPA knockdown/overexpression, promoter binding assay for HOXD10, in vivo mouse endometriosis model with lentiviral HOXD10 overexpression iScience Low 39759007
1995 The GABPA (E4TF1-60) gene was mapped to human chromosome 21q21.2-q21.3 and shown to contain ten exons. GABPA is an ETS-related DNA-binding protein that forms heterodimers with other polypeptides. Genomic Southern hybridization, exon sequencing, FISH (independently confirmed by FISH, somatic cell hybrids, YAC hybridization in PMID:7590737) Gene Medium 7590737 8543189

Source papers

Stage 0 corpus · 39 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2015 Nrf2--a therapeutic target for the treatment of neurodegenerative diseases. Free radical biology & medicine 282 26281945
2015 Nrf2--A regulator of keratinocyte redox signaling. Free radical biology & medicine 148 25912479
2018 Nrf2a modulates the embryonic antioxidant response to perfluorooctanesulfonic acid (PFOS) in the zebrafish, Danio rerio. Aquatic toxicology (Amsterdam, Netherlands) 49 29524743
2018 GABPA inhibits invasion/metastasis in papillary thyroid carcinoma by regulating DICER1 expression. Oncogene 49 30181547
2015 Regulation of Ahr signaling by Nrf2 during development: Effects of Nrf2a deficiency on PCB126 embryotoxicity in zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands) 49 26325326
2019 GABPA is a master regulator of luminal identity and restrains aggressive diseases in bladder cancer. Cell death and differentiation 45 31802036
2015 CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC. PLoS genetics 39 25830341
2014 METTL23, a transcriptional partner of GABPA, is essential for human cognition. Human molecular genetics 36 24501276
2012 The ETS transcription factors ELK1 and GABPA regulate different gene networks to control MCF10A breast epithelial cell migration. PloS one 33 23284628
2020 Nrf2-A Molecular Target for Sepsis Patients in Critical Care. Biomolecules 28 33348637
2020 GABPA-dependent down-regulation of DICER1 in follicular thyroid tumours. Endocrine-related cancer 27 32163919
2022 GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma. Journal of experimental & clinical cancer research : CR 24 35549739
2017 ETS transcription factor family member GABPA contributes to vitamin D receptor target gene regulation. The Journal of steroid biochemistry and molecular biology 22 28870774
2016 Human Lineage-Specific Transcriptional Regulation through GA-Binding Protein Transcription Factor Alpha (GABPa). Molecular biology and evolution 21 26814189
2022 Up-Regulation of RACGAP1 Promotes Progressions of Hepatocellular Carcinoma Regulated by GABPA via PI3K/AKT Pathway. Oxidative medicine and cellular longevity 20 35958019
2014 Heme acts through the Bach1b/Nrf2a-MafK pathway to regulate exocrine peptidase precursor genes in porphyric zebrafish. Disease models & mechanisms 20 24652768
2021 Synergistic activation of mutant TERT promoter by Sp1 and GABPA in BRAFV600E-driven human cancers. NPJ precision oncology 19 33483600
2014 Preferred binding of gain-of-function mutant p53 to bidirectional promoters with coordinated binding of ETS1 and GABPA to multiple binding sites. Oncotarget 15 24481480
2025 The transcription factor GABPA is a master regulator of naive pluripotency. Nature cell biology 13 39747581
2023 Nrf2--a hidden bridge linking cancer stem cells to ferroptosis. Critical reviews in oncology/hematology 13 37598896
2018 Increased susceptibility to oxidative stress-induced toxicological evaluation by genetically modified nrf2a-deficient zebrafish. Journal of pharmacological and toxicological methods 13 30594530
2020 Embryonic exposures to mono-2-ethylhexyl phthalate induce larval steatosis in zebrafish independent of Nrf2a signaling. Journal of developmental origins of health and disease 12 32063256
2021 The Nrf2a pathway impacts zebrafish offspring development with maternal preconception exposure to perfluorobutanesulfonic acid. Chemosphere 11 34509758
2020 CRISPR-Generated Nrf2a Loss- and Gain-of-Function Mutants Facilitate Mechanistic Analysis of Chemical Oxidative Stress-Mediated Toxicity in Zebrafish. Chemical research in toxicology 8 31858786
2019 Identification of GA-Binding Protein Transcription Factor Alpha Subunit (GABPA) as a Novel Bookmarking Factor. International journal of molecular sciences 8 30836589
1995 Assignment of the E4TF1-60 gene to human chromosome 21q21.2-q21.3. Gene 8 8543189
1995 Mapping of the human transcription factor GABPA (E4TF1-60) gene to chromosome 21. Genomics 7 7590737
2024 GABPA inhibits tumorigenesis in clear cell renal cell carcinoma by regulating ferroptosis through ACSL4. Scientific reports 6 39489850
2023 Evaluation of the oxidative toxicity induced by lead, manganese, and cadmium using genetically modified nrf2a-mutant zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 5 36717045
2023 Prohibitin2/PHB2, Transcriptionally Regulated by GABPA, Inhibits Cell Growth via PRKN/Parkin-dependent Mitophagy in Endometriosis. Reproductive sciences (Thousand Oaks, Calif.) 5 37587393
2022 GABPA protects against gastric cancer deterioration via negatively regulating GPX1. Journal of medical biochemistry 5 36042907
2024 GABPA-Mediated Expression of HPN-AS1 Facilitates Cell Apoptosis and Inhibits Cell Proliferation in Hepatocellular Carcinoma by Promoting eIF4A3 Degradation. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 3 39114737
2025 The ETS transcription factor GABPA inhibits bladder cancer aggressiveness by repressing extracellular matrix deposition and mechanotransduction signaling. Cell death & disease 1 40813762
2025 Suppressing the OTUD7A/KDM5B/GABPA axis enhances the sensitivity of cisplatin through inducing ferroptosis in KRAS-mutant LUAD. Cell death & disease 1 41422226
2024 Crucial role of lncRNA NONHSAG037054.2 and GABPA, and their related functional networks, in ankylosing spondylitis. Experimental and therapeutic medicine 1 38628657
2024 miR-450b-5p promotes development of endometriosis by inhibiting the GABPA/HOXD10 axis. iScience 1 39759007
2021 TERT and its binding protein: overexpression of GABPA/B in high grade gliomas. Oncotarget 1 34194624
2025 HMGB1 activates caspase-1 and induces hepatic stellate cell activation via GABPA-ASC. Biochimica et biophysica acta. Molecular cell research 0 40749747
2024 The transcription factor GABPA is a master regulator of naïve pluripotency. bioRxiv : the preprint server for biology 0 39605507

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