Affinage

PRPS2

Ribose-phosphate pyrophosphokinase 2 · UniProt P11908

Round 2 corrected
Length
318 aa
Mass
34.8 kDa
Annotated
2026-04-28
46 papers in source corpus 16 papers cited in narrative 16 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PRPS2 is an X-linked phosphoribosyl pyrophosphate synthetase that couples nucleotide biosynthesis to oncogenic signaling and redox homeostasis. It catalyzes PRPP synthesis within a heteromeric complex containing PRPS1, PRPSAP1, and PRPSAP2, where PRPS2 is required for proper PRPS1 assembly and maximal metabolic flux; its hexamers stack into higher-order polymers that are essential for full catalytic activity and are inhibited by ADP binding at both allosteric and active sites (PMID:37248548, PMID:36742181). PRPS2 is transcriptionally activated by c-Myc and translationally upregulated via an eIF4E-responsive 5′ UTR element, making it a rate-limiting node for Myc-driven tumorigenesis; a Prps2 knockout mouse is viable but resistant to Myc-induced lymphomagenesis (PMID:24855946, PMID:18677108). Beyond its enzymatic role, PRPS2 has an enzyme-independent function in stabilizing MAT2A to drive SAM synthesis and RNA m6A methylation, and it regulates NADPH/NADP⁺ redox balance in MYC-driven lymphoma, tumor immune microenvironment remodeling via CCL2-dependent macrophage/MDSC recruitment, and invasion through MMP-9/E-cadherin (PMID:40295500, PMID:38952044, PMID:30908912).

Mechanistic history

Synthesis pass · year-by-year structured walk · 13 steps
  1. 1989 Medium

    Mapping PRPS2 to the X chromosome at a locus distinct from PRPS1 established that two independent PRPS isozymes exist in humans, raising the question of whether they serve non-redundant roles.

    Evidence Southern blot analysis of human–mouse somatic cell hybrids and flow-sorted chromosomes

    PMID:2536962

    Open questions at the time
    • No functional distinction between isozymes established at this stage
    • Expression pattern differences not characterized
  2. 1992 Medium

    Characterization of the PRPS2 promoter revealed GC-rich architecture with Sp1 sites and cell-type-differential activity, providing the first evidence that PRPS2 expression is transcriptionally regulated.

    Evidence CAT/promoter fusion reporter assays in four cell lines

    PMID:1314091

    Open questions at the time
    • Specific transcription factors driving differential expression were not identified
    • No in vivo promoter validation
  3. 2008 High

    Identification of PRPS2 as a direct MYC transcriptional target that is rate-limiting for dNTP pools established its integration into the MYC-driven anabolic program and explained why PRPS2 depletion phenocopies MYC loss in proliferating melanoma cells.

    Evidence ChIP for MYC binding at PRPS2, shRNA knockdown, cDNA overexpression, dNTP pool measurements, cell cycle analysis

    PMID:18677108

    Open questions at the time
    • Mechanism by which PRPS2 is selected over PRPS1 by MYC not resolved
    • Translational versus transcriptional regulation not dissected
  4. 2014 High

    Demonstration that PRPS2 is translationally upregulated by the Myc→eIF4E axis through a specialized 5′ UTR element—and that Prps2 knockout mice resist Myc-driven tumorigenesis—unified transcriptional and translational control of PRPS2 into a single oncogenic circuit coupling protein synthesis to nucleotide biosynthesis.

    Evidence 5′ UTR reporter assays, Prps2 knockout mouse, Myc-transformed cell lines, metabolic assays

    PMID:24855946

    Open questions at the time
    • Identity of RNA-binding proteins or structures within the 5′ UTR that mediate eIF4E sensitivity not defined
    • Whether PRPS2 loss affects non-Myc oncogene contexts not tested
  5. 2015 Medium

    Gain- and loss-of-function experiments in Sertoli cells placed PRPS2 upstream of p53/Bcl-2/caspase apoptosis cascades, revealing a role for PRPS2 in cell survival beyond nucleotide supply.

    Evidence Lentiviral overexpression and knockdown in TM4 Sertoli cells, flow cytometry for apoptosis and cell cycle

    PMID:26004865

    Open questions at the time
    • Whether the anti-apoptotic effect is enzymatic or enzyme-independent not determined
    • Single cell type, not confirmed in vivo
  6. 2019 Medium

    Linking PRPS2 to MMP-9 activation and E-cadherin downregulation in colorectal cancer cells extended its oncogenic role from proliferation to invasion and metastasis.

    Evidence PRM-targeted proteomics, migration/invasion assays, MMP-9 activity assay, siRNA knockdown

    PMID:30908912

    Open questions at the time
    • Molecular mechanism connecting PRPS2 to MMP-9/E-cadherin regulation not elucidated
    • Single lab, no in vivo validation of metastasis phenotype
  7. 2020 Medium

    In vivo PRPS2 knockdown in mouse testes causing hypospermatogenesis and spermatogenic apoptosis through E2F1 established a physiological role for PRPS2 in male germline maintenance beyond cancer.

    Evidence In vivo testicular knockdown, spermatogenic cell apoptosis quantification, E2F1 target gene analysis

    PMID:31736475

    Open questions at the time
    • Whether the fertility phenotype reflects nucleotide depletion or a non-catalytic function is unclear
    • Full knockout fertility phenotype not reported
  8. 2022 High

    Discovery that relapse-specific PRPS2 mutations in childhood ALL disrupt hexamer interfaces and reduce ADP/GDP feedback inhibition explained a clinical mechanism of thiopurine resistance and showed that allosteric regulation of PRPS2 is pharmacologically relevant.

    Evidence Ultra-deep sequencing of relapse ALL, in vitro enzyme activity and feedback inhibition assays, UPLC-MS/MS metabolomics, xenograft models

    PMID:36742181

    Open questions at the time
    • Crystal structures of mutant PRPS2 hexamers not determined
    • Whether combination targeting of PRPS1 and PRPS2 can overcome resistance not tested
  9. 2023 High

    The 3.08 Å cryo-EM structure of PRPS2 hexamer polymers and mutagenesis of inter-hexamer contacts demonstrated that polymerization is required for full catalytic activity and defined ADP inhibition at atomic resolution, providing the first structural framework for PRPS2 regulation.

    Evidence Cryo-EM at 3.08 Å, site-directed mutagenesis, in vitro polymerization and activity assays

    PMID:37248548

    Open questions at the time
    • Structure of the full heteromeric PRPS complex with PRPSAP1/PRPSAP2 not resolved
    • In-cell polymer dynamics not observed
  10. 2024 Medium

    Combinatorial genetic dissection of the PRPS complex showed that PRPS2, PRPSAP1, and PRPSAP2 are all required for proper PRPS1 assembly, establishing PRPS2 as an obligate component of the functional heteromeric complex rather than a redundant isozyme.

    Evidence Isogenic fibroblast knockout clones (individual and combinatorial), co-fractionation, metabolic flux analysis (preprint)

    PMID:bio_10.1101_2024.10.01.616059

    Open questions at the time
    • Preprint, not yet peer-reviewed
    • Stoichiometry of subunits in the native complex not determined
    • Whether complex composition varies across tissues not explored
  11. 2024 Medium

    Identification of CCL2 as a PRPS2-regulated chemokine that recruits TAMs and MDSCs in lung cancer extended PRPS2's oncogenic role to immune evasion and tumor microenvironment remodeling.

    Evidence In vivo LLC tumor models, FACS immune profiling, transwell chemotaxis, CCL2 neutralizing antibody rescue

    PMID:38952044

    Open questions at the time
    • Whether the CCL2 effect depends on PRPS2 enzymatic activity or is enzyme-independent not addressed
    • Human tumor validation lacking
  12. 2025 High

    Discovery that PRPS2 directly binds and stabilizes MAT2A to drive SAM synthesis and m6A RNA methylation—independent of its PRPP-synthesizing activity—established the first non-catalytic scaffolding function of PRPS2 and explained four non-conserved residues that bypass allosteric feedback inhibition to sustain oncogenic ATP production.

    Evidence Co-IP, protein stability assays, mutational analysis of allosteric sites, m6A methylation assays, in vivo tumorigenesis assays

    PMID:40295500

    Open questions at the time
    • Structural basis of the PRPS2–MAT2A interaction not resolved
    • Whether enzyme-independent functions extend to other metabolic enzymes not explored
  13. 2025 Medium

    Transcriptional repression of PRPS2 by YBX1-mediated displacement of c-Myc and recruitment of the NuRD corepressor complex revealed a druggable upstream node for PRPS2 suppression in triple-negative breast cancer.

    Evidence PRPS2-promoter luciferase, ChIP, biotin-conjugated pull-down, murine metastasis model

    PMID:41855762

    Open questions at the time
    • Relevance beyond TNBC not tested
    • Whether YBX1-mediated repression operates in normal tissues not examined

Open questions

Synthesis pass · forward-looking unresolved questions
  • Key unresolved questions include the structure of the native heteromeric PRPS1/PRPS2/PRPSAP1/PRPSAP2 complex, the tissue-specific balance between PRPS2 catalytic and non-catalytic functions, whether PRPS2-selective inhibitors can be developed as anti-cancer agents, and how PRPS2's redox regulatory role intersects with its nucleotide biosynthetic and scaffolding activities.
  • No selective PRPS2 inhibitor reported
  • Structural basis of PRPS2–MAT2A interaction unknown
  • In vivo dissection of catalytic versus non-catalytic functions not performed

Mechanism profile

Synthesis pass · controlled-vocabulary classification · explore literature graph →
Molecular activity
GO:0016740 transferase activity 4 GO:0098772 molecular function regulator activity 2
Localization
GO:0005829 cytosol 2
Pathway
R-HSA-1430728 Metabolism 4 R-HSA-1643685 Disease 3 R-HSA-8953854 Metabolism of RNA 1
Partners
EIF4EMAT2AMYCPRPS1PRPSAP1PRPSAP2YBX1
Complex memberships
PRPS heteromeric complex (PRPS1/PRPS2/PRPSAP1/PRPSAP2)

Evidence

Reading pass · 16 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2014 PRPS2 is a rate-limiting enzyme for nucleotide biosynthesis that is specifically upregulated at the translational level downstream of Myc activation via a specialized cis-regulatory element in the PRPS2 5' UTR controlled by the translation initiation factor eIF4E. A Prps2 knockout mouse demonstrated that this Myc→eIF4E→PRPS2 axis is required for Myc-driven tumorigenesis, coupling protein synthesis (via eIF4E) and nucleotide biosynthesis (via PRPS2) in a single anabolic circuit. 5' UTR reporter assays, Prps2 knockout mouse, Myc-transformed cell lines, metabolic assays Cell High 24855946
2008 PRPS2 is a direct transcriptional target of C-MYC and is rate-limiting for dNTP metabolism in melanoma cells. shRNA-mediated knockdown of PRPS2 reduced dNTP pools and retarded cell cycle progression similarly to C-MYC depletion; conversely, PRPS2 overexpression (together with TS and IMPDH2) delayed proliferative arrest caused by C-MYC inhibition. ChIP confirmed direct C-MYC binding to the PRPS2 gene. shRNA knockdown, cDNA overexpression, dNTP pool measurements, ChIP, cell cycle analysis Cell cycle (Georgetown, Tex.) High 18677108
2023 Cryo-EM structure of human PRPS2 at 3.08 Å resolution revealed that hPRPS2 hexamers stack into polymers in the presence of the allosteric/competitive inhibitor ADP. The binding modes of ADP at the canonical allosteric site and at the catalytic active site were determined. A point mutation disrupting inter-hexamer contacts prevents hPRPS2 polymerization and results in significantly reduced catalytic activity, demonstrating that polymer formation regulates enzymatic activity. The regulation of hPRPS2 polymers is distinct from that of E. coli PRPS polymers. Cryo-EM structure determination (3.08 Å), site-directed mutagenesis, in vitro polymerization and activity assays Cell & bioscience High 37248548
2022 PRPS2 mutations found exclusively in relapsed childhood ALL drive thiopurine resistance by influencing PRPS1/PRPS2 hexamer stability. The 3-amino acid insertion V103-G104-E105 in PRPS2 causes steric clash at the hexamer interface, reducing enzyme activity. Functional PRPS2 mutations reduce ADP/GDP feedback inhibition of PRPS enzyme activity, enhancing purine metabolic flux and thiopurine resistance, demonstrated in cell lines and xenograft models. Ultra-deep sequencing, in vitro PRPS2 enzyme activity assays, ADP/GDP feedback inhibition assays, UPLC-MS/MS metabolite profiling, xenograft mouse models Blood science (Baltimore, Md.) High 36742181
2025 PRPS2 uses four non-conserved key residues to bypass typical ADP/GDP allosteric feedback inhibition, enabling sustained excess ATP production. Additionally, PRPS2 directly interacts with and stabilizes methionine adenosyltransferase 2A (MAT2A) through protein-protein interaction, stimulating SAM synthesis which feeds the WTAP/METTL3/METTL14 methyltransferase complex for RNA m6A methylation, thereby promoting lung tumorigenesis. This reveals both enzyme-dependent (ATP production) and enzyme-independent (MAT2A stabilization) oncogenic functions of PRPS2. Co-immunoprecipitation, protein stability assays, mutational analysis of allosteric sites, m6A methylation assays, in vitro and in vivo tumorigenesis assays, MAT2A interaction studies Nature communications High 40295500
2019 PRPS2 promotes migration and invasion of colorectal cancer cells by regulating the activity of matrix metalloproteinase 9 (MMP-9) and the expression of E-cadherin. Upregulation of PRPS2 in metastatic CRC cells is induced by the MYC proto-oncogene. PRM-based targeted proteomics, migration/invasion assays, MMP-9 activity assays, Western blot, siRNA knockdown Journal of proteome research Medium 30908912
2015 PRPS2 overexpression in TM4 Sertoli cells inhibits apoptosis and promotes cell cycle transition via the p53/Bcl-2/caspase-9/caspase-3/caspase-6/caspase-7 signaling pathway, as demonstrated by lentiviral gain- and loss-of-function experiments with flow cytometry readouts. Lentiviral overexpression and knockdown, flow cytometry (apoptosis, cell cycle), Western blot for apoptosis pathway proteins The Journal of urology Medium 26004865
2020 PRPS2 depletion in mouse testes causes hypospermatogenesis and accelerated spermatogenic cell apoptosis. E2F1 transcription factor was identified as a target gene regulated by PRPS2, with E2F1 acting through the P53/Bcl-xl/Bcl-2/Caspase 6/Caspase 9 apoptosis pathway. In vivo knockdown of PRPS2 in mouse testes confirmed the hypospermatogenesis phenotype. In vivo testicular PRPS2 knockdown in mice, spermatogenic cell apoptosis quantification, E2F1 target gene analysis, apoptosis pathway protein assays Asian journal of andrology Medium 31736475
2021 PRPS2 silencing enhances cisplatin sensitivity in NSCLC cells. PRPS2 is enriched in exosomes secreted by NSCLC cells, and exosomal PRPS2 mediates M2 macrophage polarization, which in turn promotes cisplatin resistance in NSCLC cells. siRNA knockdown, exosome isolation by ultracentrifugation, MTT and colony formation assays, ELISA, caspase-3 activity assay, macrophage polarization assays Immunological investigations Medium 34251965
2024 PRPS2 regulates chemotaxis of tumor-associated macrophages (TAM) and myeloid-derived suppressor cells (MDSC) in lung cancer by controlling CCL2 expression. In vivo LLC tumor models showed that PRPS2 knockdown reduced TAM/MDSC infiltration and increased CD4+/CD8+ T cell percentages; CCL2 antibody treatment reversed the pro-tumorigenic phenotype induced by PRPS2 overexpression. Lentiviral stable cell lines, in vivo mouse tumor models, FACS, in vitro transwell chemotaxis assay, qPCR, Western blot, ELISA Thoracic cancer Medium 38952044
2024 Host PRPS2 directly interacts with Avian Reovirus non-structural protein p17, as validated by yeast two-hybrid, coimmunoprecipitation, GST-pulldown, and laser confocal microscopy. The C-terminal region of PRPS2 is responsible for binding p17. ARV infection upregulates PRPS2, and PRPS2 overexpression increases ARV replication while knockdown decreases it, with cellular apoptosis implicated as a mechanism. Yeast two-hybrid, coimmunoprecipitation, GST-pulldown, laser confocal microscopy, overexpression and knockdown in avian cells Poultry science Medium 39631276
2025 Genetic inactivation of the PRPS2 isozyme (but not PRPS1) in MYC-driven lymphoma cells leads to elevated NADPH levels and reductive stress-mediated cell death, identifying PRPS2 as a primary regulator of redox homeostasis in Myc-overexpressing B cell lymphomas. MYC overexpression rapidly stimulates PRPS2-dependent nucleotide synthesis and modulates the pentose phosphate pathway and mitochondrial respiration to shift redox equilibrium toward a more oxidative state. Pharmacological targeting of PRPS1 versus PRPS2 elicits opposing sensitivity or resistance to thioredoxin/glutathione network-targeting chemotherapeutics. Genetic isozyme-specific inactivation (PRPS2 KO vs PRPS1 KO), NADPH measurements, pharmacological screen, redox assays in MYC-overexpressing B cell lymphoma cells bioRxivpreprint Medium bio_10.1101_2025.01.08.632009
2024 PRPS2 operates as part of a large mammalian PRPS enzyme complex together with PRPS1, PRPS3 (testis-restricted), and two non-enzymatic associated proteins (PRPSAP1, PRPSAP2). PRPS2, PRPSAP1, and PRPSAP2 are required for proper PRPS1 assembly; cells lacking all three render PRPS1 into aberrant homo-oligomeric assemblies with diminished metabolic flux and impaired proliferative capacity. Preferential interactions between complex subunits were defined using isogenic fibroblast clones in all viable individual or combinatorial assembly states. Translational control mechanisms enable fine-tuned regulation of PRPS complex assembly. Isogenic fibroblast knockout clones (individual and combinatorial), co-fractionation, affinity purification, metabolic flux analysis, proliferation assays bioRxivpreprint Medium bio_10.1101_2024.10.01.616059
1989 The PRPS2 gene was localized to the X chromosome at a different region than PRPS1, specifically Xpter-q21, using Southern blot analysis of human-mouse somatic cell hybrids and flow-sorted human chromosomes, demonstrating that PRPS1 and PRPS2 are encoded by distinct, separated loci on the X chromosome. Southern blot analysis of somatic cell hybrids, flow-sorted chromosome hybridization Somatic cell and molecular genetics Medium 2536962
1992 The PRPS2 gene promoter region is GC-rich, contains a TATA-like sequence, four Sp1 binding sites, and a homopyrimidine stretch, with transcription initiation sites 90 nucleotides upstream from the ATG codon. CAT/promoter fusion assays in four cell lines demonstrated that a 1.1 kb PRPS2 5'-flanking region possesses promoter activity correlated with steady-state PRPS2 mRNA levels, suggesting this region drives cell-differential expression. Promoter cloning, sequencing, CAT/promoter fusion reporter assays in multiple cell lines Biochimica et biophysica acta Medium 1314091
2026 Pseudoginsenoside F11 (PF11) inhibits PRPS2 transcription by binding to the transcription factor YBX1, enhancing its affinity for the PRPS2 promoter and enabling displacement of the transcriptional activator c-Myc. YBX1 then recruits the NuRD corepressor complex to the PRPS2 promoter, leading to transcriptional repression of PRPS2, suppression of TNBC stemness, and reduction of pulmonary metastasis in murine models. PRPS2-promoter luciferase reporter assay, biotin-conjugated pull-down, ChIP, YBX1 knockdown/overexpression, in vitro mammosphere assay, murine pulmonary metastasis model Phytomedicine Medium 41855762

Source papers

Stage 0 corpus · 46 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America 1479 12477932
2015 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 1118 26186194
2017 Architecture of the human interactome defines protein communities and disease networks. Nature 1085 28514442
2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell 1015 26496610
2014 A proteome-scale map of the human interactome network. Cell 977 25416956
2020 A reference map of the human binary protein interactome. Nature 849 32296183
2021 Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Cell 705 33961781
2012 A census of human soluble protein complexes. Cell 689 22939629
2011 Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Briefings in bioinformatics 656 21873635
2021 Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature 532 33845483
2015 Widespread macromolecular interaction perturbations in human genetic disorders. Cell 454 25910212
2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome research 438 15489334
2015 A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell 433 26638075
2022 OpenCell: Endogenous tagging for the cartography of human cellular organization. Science (New York, N.Y.) 432 35271311
2005 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Genome research 409 16344560
2015 Panorama of ancient metazoan macromolecular complexes. Nature 407 26344197
1996 Normalization and subtraction: two approaches to facilitate gene discovery. Genome research 401 8889548
2016 Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics. Cell reports 306 27342126
2012 A high-throughput approach for measuring temporal changes in the interactome. Nature methods 273 22863883
2008 Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells. Cell cycle (Georgetown, Tex.) 212 18677108
2016 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nature communications 211 27173435
2009 Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Science signaling 207 19738201
2014 Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer. Cell 204 24855946
2016 Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon. Molecular cell 144 26990986
2013 Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. Cell metabolism 142 23891004
2009 Ubiquitin-mediated proteolysis of HuR by heat shock. The EMBO journal 142 19322201
2022 A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets. Nature biotechnology 140 36217030
2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Journal of proteomics 126 23376485
2018 Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN. Nature communications 123 30425250
2022 The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin. Nature cell biology 122 35013556
2021 Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers. Nature genetics 116 34857952
1989 Localization of human phosphoribosylpyrophosphate synthetase subunit I and II genes (PRPS1 and PRPS2) to different regions of the X chromosome and assignment of two PRPS1-related genes to autosomes. Somatic cell and molecular genetics 48 2536962
1990 Cloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes. Genomics 47 1962753
2015 PRPS2 Expression Correlates with Sertoli-Cell Only Syndrome and Inhibits the Apoptosis of TM4 Sertoli Cells. The Journal of urology 21 26004865
2023 Structural basis of human PRPS2 filaments. Cell & bioscience 18 37248548
2021 PRPS2 Enhances Resistance to Cisplatin via Facilitating Exosomes-mediated Macrophage M2 Polarization in Non-small Cell Lung Cancer. Immunological investigations 17 34251965
1992 Promoter regions of the human X-linked housekeeping genes PRPS1 and PRPS2 encoding phosphoribosylpyrophosphate synthetase subunit I and II isoforms. Biochimica et biophysica acta 17 1314091
2019 Targeted Quantitative Kinome Analysis Identifies PRPS2 as a Promoter for Colorectal Cancer Metastasis. Journal of proteome research 16 30908912
2020 Phosphoribosyl-pyrophosphate synthetase 2 (PRPS2) depletion regulates spermatogenic cell apoptosis and is correlated with hypospermatogenesis. Asian journal of andrology 11 31736475
2025 PRPS2 enhances RNA m6A methylation by stimulating SAM synthesis through enzyme-dependent and independent mechanisms. Nature communications 7 40295500
2022 PRPS2 mutations drive acute lymphoblastic leukemia relapse through influencing PRPS1/2 hexamer stability. Blood science (Baltimore, Md.) 7 36742181
2024 PRPS2-mediated modulation of the antitumor immune response in lung cancer through CCL2-mediated tumor-associated macrophages and myeloid-derived suppressor cells. Thoracic cancer 5 38952044
1994 Linkage of phosphoribosylpyrophosphate synthetases 1 and 2, Prps1 and Prps2, on the mouse X chromosome. Mammalian genome : official journal of the International Mammalian Genome Society 4 7849396
2024 Host protein PRPS2 interact with the non-structural protein p17 of Avian Reovirus and promote viral replication. Poultry science 3 39631276
2026 Pseudoginsenoside F11 enhances YBX1-mediated transcriptional repression of PRPS2 to inhibit the stemness and pulmonary metastasis of triple- negative breast cancer. Phytomedicine : international journal of phytotherapy and phytopharmacology 0 41855762
2025 MtfA, a C2H2 transcriptional regulator, negatively regulates PRPS2-mediated biosynthesis of the adenosine analogue acadesine in Fusarium solani. Mycology 0 41878508